Digital Commons Network^™

Deciphering The Role And Clinical Application Of The Fgfr4-Klb-Fgf19 Axis In Colorectal Neoplastic Progression, Michael Rohr

Electronic Theses and Dissertations, 2020-2023

Colorectal cancer (CRC) is the third most common and third deadliest cancer worldwide with rising incidence rates attributed to environmental risk factors like diet. Investigating how these factors impact carcinogenesis requires an understanding of how transcriptional events evolve with respect to neoplastic progression. We employed meta-transcriptomics and latent trajectory modeling to establish a compendium of profiled healthy, adenoma, and CRC samples scored by their position along a pseudotemporal axis. By interpolating a continuous scale from cross-sectional data, dynamic processes occurring throughout disease progression can be analyzed more accurately. For example, smaller pseudotimes represented pre-malignant dysplasia and was characterized by cellular …

Physics And Applications Of Space-Time Wave Packets, Murat Yessenov

Electronic Theses and Dissertations, 2020-2023

Space-time wave packets (STWP) constitute a broad class of pulsed optical fields that are rigidly transported in linear media without diffraction or dispersion, and are therefore propagation-invariant in absence of optical nonlinearities or waveguiding structures. Such wave packets exhibit unique characteristics, such as controllable group velocities in free space and exotic refractive phenomena. At the root of these behaviors is a fundamental feature underpinning STWP: their spectra are not separable with respect to the spatial and temporal degrees of freedom. Indeed, the spatio-temporal structure is endowed with angular dispersion, in which each spatial frequency is associated with a single prescribed …

Development Of A Computational Application To Aid With Chemometric And Forensic Analysis Of Fire Debris Samples, Michelle Corbally

Electronic Theses and Dissertations, 2020-2023

Fire debris analysis is a forensic science discipline that determines if an ignitable liquid residue is present or absent in a fire debris sample. Currently, fire debris analysis results in categorical statements based on qualitative data, not the quantitative evidentiary value of data. The purpose of this research was to develop a novel software application to aid fire debris analysts in the identification and classification of ignitable liquid residues that are found in fire debris samples. The developed application uses target factor analysis (TFA) and Pearson correlation for compound identification in gas chromatograms using mass spectral comparison and allows for …

Development Of Holographic Phase Masks For Wavefront Shaping, Nafiseh Mohammadian

Electronic Theses and Dissertations, 2020-2023

This dissertation explores a new method for creating holographic phase masks (HPMs), which are phase transforming optical elements holographically recorded in photosensitive glass. This novel hologram recording method allows for the fast production of HPMs of any complexity, as opposed to the traditional multistep process, which includes the design and fabrication of a master phase mask operating in the UV region before the holographic recording step. We holographically recorded transmissive HPMs that are physically robust (they are recorded in a silicate glass volume), can handle tens of kilowatts of continuous wave (CW) laser power, are un-erasable, user defined, require no …

The Sociology Of God: The Case Of Homeless Believers, John L'Hommedieu

Electronic Theses and Dissertations, 2020-2023

This research began as personal curiosity about the religious beliefs of persons experiencing homelessness, and in particular their beliefs about God. What do they believe about God, and how are their beliefs socially constructed? Social research has generally limited its focus to assessing religion as an asset in ameliorating homelessness as a social problem with little attention to the religious behaviors and thought processes of persons experiencing homelessness themselves. I conducted a classic grounded theory (CGT) analysis based on 14 in-depth interviews with homeless believers (HB's) and three interviews with pastors-service-providers (PSP's) for comparative analysis. The findings include two major …

Attenuation Of Excess Tnfα Release In Crohn's Disease By Silencing Of Irhoms 1/2 And The Restoration Of Tgfβ-Mediated Immunosuppression Through The Modulation Of Tace Trafficking, Taylor Louis

Electronic Theses and Dissertations, 2020-2023

Although treatment of Crohn's disease (CD) with TNFa monoclonal antibodies is beneficial, many patients stop responding over time and become at risk of acquiring infections. This study investigated an alternative approach to attenuate the release of excess TNFα by silencing iRHOMs 1/2 with the intention of restoring TGFβ-mediated Immunosuppression through Mitigation of TNFα converting enzyme (TACE) Trafficking. TACE, a transmembrane metalloprotease involved in signaling of receptors/cytokines/growth factors/adhesion proteins, is upregulated in CD, resulting in a marked increase of membranous TNFα cleavage and inflammation. Initially, we measured TGFβRII shedding in plasma from CD patients and healthy controls (N=40 per group). We …

Applications For Machine Learning On Readily Available Data From Virtual Reality Training Experiences, Alec Moore

Electronic Theses and Dissertations, 2020-2023

The purpose of the research presented in this dissertation is to improve virtual reality (VR) training systems by enhancing their understanding of users. While the field of intelligent tutoring systems (ITS) has seen value in this approach, much research into making use of biometrics to improve user understanding and subsequently training, relies on specialized hardware. Through the presented research, I show that with machine learning (ML), the VR system itself can serve as that specialized hardware for VR training systems. I begin by discussing my explorations into using an ecologically valid, specialized training simulation as a testbed to predict knowledge …

An Anthropological Study Of The Effects Of The Covid-19 Pandemic On Drug Treatment In The United States, Abigail Shepherd

Electronic Theses and Dissertations, 2020-2023

This thesis examined the extent to which the COVID-19 pandemic has affected the structure of drug treatment in the United States and how the effects have influenced the experience of undergoing and providing services in a variety of contexts. The COVID-19 pandemic emerged amid an opioid epidemic, which has taken the lives of over 564,000 Americans since the late 1990s. With overdose deaths increasing since the onset of the pandemic and government agencies responding with policy changes, recent research in the social sciences and on drug treatment services has necessarily shifted its focus to the effects of the pandemic on …

Cholera Transmission Dynamic Model With Environmental Impacts Of Plankton Reservoirs, Sweety Sarker

Electronic Theses and Dissertations, 2020-2023

Cholera is an acute disease that is a global threat to the world and can kill people within a few hours if left untreated. In the last 200 years, seven pandemics occurred, and, in some countries, it remains endemic. The World Health Organization (WHO) declared a global initiative to prevent cholera by 2030. Cholera dynamics are contributed by several environmental factors such as salinity level of water, water temperature, presence of plankton especially zooplankton such as cladocerans, rotifers, copepods, etc. Vibrio cholerae (V. cholerae) bacterium is the main reason behind the cholera disease and the growth of V. cholerae depends …

Atmospheric Retrieval: Bayesian Methods, Machine Learning, And Application To Exoplanets, Michael Himes

Electronic Theses and Dissertations, 2020-2023

Atmospheric retrieval is the inverse modeling method where atmospheric properties are constrained based on measured spectra. Due to the low signal-to-noise ratios of exoplanet observations, exoplanetary retrieval codes pair a radiative transfer (RT) simulator with a Bayesian statistical framework in order to characterize the distribution of atmospheric parameters that could explain the observations (the posterior distribution). This requires on the order of 106 RT model evaluations, which requires hours to days of compute time depending on model complexity. In this work, I investigate atmospheric retrieval methods and apply them to observations of hot Jupiters. Chapter 2 presents a set of …

Homicide Patterns In Urban Places:A Geospatial Analysis Of Homicide In Baltimore, M.D., Kayla Toohy

Electronic Theses and Dissertations, 2020-2023

Extant criminological research examining research questions oriented on understanding the spatial distribution of violent crime instances, such as homicide, have often employed the theoretical foundations of both social disorganization theory and routine activities theory. Though there is much research using these theories independently and in conjunction with one another, few studies have integrated the theories in analyses of homicide at multiple levels of aggregation. The current study is conducted to analyze homicide incidents in Baltimore, Maryland from 2014 through 2018. The analysis conducted considers both social disorganization and routine activities theory variables to test the explanatory power of each theory …

Castle Of Unknowing: An Immersive Virtual Reality Experience, Damian Thorn-Hauswirth

Electronic Theses and Dissertations, 2020-2023

Castle of Unknowing is a rendered virtual reality (VR) experience presented as visual poem. As VR is a nascent technology, content is still limited, and methods of storytelling are not yet formalized. My film seeks to expand the breadth of what types of narratives are being told with this medium. The project is an immersive, experiential narrative imbued with symbolism. The viewer moves through a fixed sequence as they are taken on a journey which mixes elements of sci-fi, fairy tale, and surrealism. It utilizes compelling visuals and sound instead of traditional narrative to evoke an emotional response within the …

Uncovering Ophelia: The Reclamation Of Women's Madness Through Feminist Disability Studies, Amy Crawford

Electronic Theses and Dissertations, 2020-2023

In his essay "The Philosophy of Composition," Edgar Allan Poe proclaims that "the death of a beautiful woman is unquestionably the most poetical topic in the world," and this sentiment remains curiously persistent within the literary world. Artists have looked towards their beautiful muses for centuries as a source of inspiration and introspection, and the faces that these muses wear were often swooning, longing, or even dead. Nineteenth-century British aesthetics solidified a gendered ideology that remains prevalent to this day; in particular, one subculture of Victorian aesthetics that emerged during this period was the Cult of Ophelia: a collection of …

Plasmonic Sensor Based Detection Of Dopamine, Sang Lee

Electronic Theses and Dissertations, 2020-2023

With a rapidly ageing population, neurological diseases are becoming increasingly relevant in the design of public health policies and strategies in western societies. In the last decades, biochemical research has consistently shown the critical role that neurotransmitters and their associated metabolites play as biomarkers in tracking and diagnosis of different brain disorders and cancers. In particular, dopamine, an organic electrochemical neurotransmitter, has been shown to be paramount for the proper functioning of the neural system. Dopamine's dysfunction, has been shown to underlie the pathogenesis in several neurological disorders such as Parkinson's disease, depression, chronic schizophrenia and psychosis. Unfortunately, currently available …

Inventions In The Area Of Nanomaterials And Nanotechnologies. Part Iii, Leonid A. Ivanov, Li Da Xu, Svetlana R. Muminova, Aleksandr D. Ishkov, Aleksey V. Demenev

Information Technology & Decision Sciences Faculty Publications

Introduction. Advanced technologies inspire people by demonstrating the latest achievements (materials, methods, systems, technologies, devices etc.) that dramatically change the world. This, first of all, concerns nanotechnological inventions designed by scientists, engineers and specialists from different countries. Main part. The article provides an abstract overview of inventions of scientists, engineers and specialists from different countries: Russia, USA, Turkmenistan, Japan et al. The results of the creative activity of scientists, engineers and specialists, including inventions in the field of nanotechnology and nanomaterials allow, when introduced to industry, achieving a significant effect in construction, housing and communal services, and related sectors of …

Polymer Derived Ceramic For Lithium-Ion Storage, And Electrospun Polyelectrolyte Fiber For Heavy Metal Ions Removal, Zeyang Zhang

Electronic Theses and Dissertations, 2020-2023

This dissertation includes two major projects. The first project investigated the great potential of polymer-derived ceramics (PDCs) as lithium-ion battery anode materials with good cycling stability and large capacity. SiCNO ceramic nanoparticles were produced by pyrolysis of polysilazane nanoparticles synthesized via an oil-in-oil emulsion crosslinking. The SiCNO nanoparticles had an average particle size of around 9 nm and contained graphitic carbon, Si3N4, and SiO2 domains. The electrochemical behavior of SiCNO nanoparticles anode was investigated to evaluate the Li-ion storage performance and understand its mechanism of Li-ion storage. The lithiation of SiCNO was observed at ~0.385 V versus Li/Li+. The anode …

Characterization Of A Malachite Green Dna Aptamer And Development Of Malachite Green Dna Aptamer Sensor, Martin O'Steen

Electronic Theses and Dissertations, 2020-2023

Hydrogels have been extensively studied for use in applications such as tissue engineering, drug delivery systems, wound dressing, actuators, valves, and sensors in Micromechanical Systems (MEMS), among others. Thermo-responsive hydrogels in particular pose various advantages such as their capability to respond to an external stimulus and reverse the response when the stimulus is removed and the ability to imbibe a significant amount of solvent and increase their volume by over 1000%. Extensive research has been conducted to tune and improve hydrogel's rate and degree of swelling and mechanical properties. Previous work showed that when synthetic clay (Laponite) is cross-linked with …

Decentralized Digital Fabrication Of Flexible Micro/Nano Devices Using A Laserjet Printer, Arshya Bamshad

Electronic Theses and Dissertations, 2020-2023

The fabrication of traditional micro/nano devices requires access to cleanrooms, complex and expensive tools, and highly-skilled labor. A facile and digital do-it-yourself (DIY) technique for the fabrication of low-cost devices on flexible substrates (paper, cloth, and plastic films) is presented in this work. A set of office-grade equipment (i.e., laserjet printer, thermal laminator, computer-aided paper cutter), and commercially available supplies (i.e., baking wax paper, furniture restoration metal-leaf) are utilized. The presented technology enables community-embedded production by removing a high technological barrier. The validity of the proposed technology was proved by designing three levels of experiments, i.e., patterns, devices, and systems. …

Gender And Madness In Victorian Britain, Amy Milne-Smith

History Faculty Publications

For decades, the history of gender and madness was a story about women. Individuals deemed lunatics were universally treated as passive victims of medio-legal forces beyond their control. New generations of scholars have looked beyond power binaries to interrogate the complex network of gender, class, family, and culture to place ‘the mad’ as historical actors in a complex and often contradictory story. This article reflects on some major themes in the British historiography of Victorian gender and madness since the mid-20th century. It highlights how feminist and anti-psychiatrist interdisciplinary works inspired new generations of historians to place gender at the …

Trade Secrecy And Innovation In Forensic Technology, Eli Siems, Katherine J. Strandburg, Nicholas Vincent

Faculty Articles

Trade secrecy is a major barrier to public scrutiny of probabilistic software tools that are increasingly used at all stages of the criminal system, from policing and investigation through trial and sentencing. Such tools allow prosecutors to leverage imperfect forensic evidence, such as DNA mixtures, smudged fingerprints, and grainy video footage. Probabilistic software tools unavoidably rely on potentially contestable assumptions, parameters, and implementation choices. Judicially recognized trade secrecy in criminal cases impedes scrutiny of these tools by defendants and the public. Previous critics have focused on secrecy’s potential to undermine the integrity and fairness of the criminal justice system, invoking …

The Impact Of Bostock V. Clayton County On Access To Health Care For Lgbtq Persons, Hiba B. Al-Ramahi

Saint Louis University Journal of Health Law & Policy

LGBTQ individuals face countless acts of discrimination in health care insurance and delivery. In spite of this inequality, there are zero LGBTQ-inclusive health insurance protections in over half of the United States. Title VII of the Civil Rights Act (Title VII) and Section 1557 of the Patient Protection and Affordable Care Act (ACA) are two federal statutes that prohibit discrimination, in relevant part, on the basis of sex. Both federal statutes have been greatly impacted by the Supreme Court decision in Bostock v. Clayton County, which interpreted “sex” in Title VII to include gender identity and sexual orientation. This …

“Woman Enough” To Win? An Analysis Of Sex Testing In College Athletics, Brenna M. Moreno

Saint Louis University Journal of Health Law & Policy

In recent years, dozens of bills restricting the rights of transgender, or trans, individuals have been introduced in state legislatures throughout the country. To date, ten states have successfully passed laws prohibiting trans athletes from competing on teams in accordance with their gender identities. For its athletes, the National Collegiate Athletic Association (NCAA), the United States’ largest intercollegiate athletic organization, has pursued a compromise to balance trans inclusion and fair competition. Established in 2011, the NCAA’s conditionally inclusive policy permits trans women—meaning those who were assigned the sex of male but identify as women—to compete on a women’s team only …

Pursuing Climate Justice: Learning The Lessons Of The Covid-19 Response, Lance Gable

Saint Louis University Journal of Health Law & Policy

The COVID-19 pandemic and the climate crisis have many parallels. Both are large disruptive events that pose foundational threats to humanity through the capacity to cause substantial harm and death to humans. Both pose complex and multifaceted challenges perpetuated by multiple factors that are difficult to interrupt or mitigate. Both are subject to evolving scientific understandings of their underlying causes and potential interventions. Both are novel challenges not previously faced by most humans alive today that comprise potential threats to human society over an extended time period. These similarities allow scholars and policymakers to extrapolate and understand how the responses …

Twelve Week Calcium Collagen Chelate Or Calcium Plus Vitamin D Supplementation Does Not Affect Bone Metabolism In Trained Cyclists, Beau K. Greer, Christopher Mojock, Bahram Arjmandi, Jeong-Su Kim, Michael Ormsbee, Lynn Panton

Exercise Science Faculty Publications

The purpose of the present study was to determine whether 12 weeks of calcium collagen chelate (CCC) supplementation during habitual training would affect body composition, bone mineral density (BMD), and biomarkers of bone metabolism in competitive cyclists. Twenty trained (maximal aerobic capacity > 50 ml/kg/min, mean training volume: 28 h/wk) male cyclists performed maximal exercise testing and 40-km time trials (TT) on an electronically braked cycle ergometer. BMD of the whole body, lumbar spine (L1-L4), and both hips were measured via dual-energy X-ray absorptiometry (DXA). The cyclists were assigned to one of two groups: 1) 6 g/d of CCC with 600 …

The Risk Factors For Self-Monitoring Of Blood Glucose Among Individuals Diagnosed With Type 2 Diabetes In Saudi Arabia, Mohammed Abdulrahman Alsuliman, Qi Zhang, Shelley Mishoe, Praveen K. Durgampudi

Community & Environmental Health Faculty Publications

Background: Lack of self-monitoring of blood glucose (SMBG) is a known risk factor for controlling type 2 diabetes mellitus (T2DM). Nevertheless, little research has been conducted on SMBG among Saudis with T2DM.

Aim: The study aimed to investigate personal and cognitive-perceptual factors for SMBG among Saudis with T2DM guided by Health Promotion Model.

Methods: A cross-sectional study was conducted with a sample size of 808 Saudi adults with T2DM utilizing secondary data from the Saudi Health Interview Survey for 2013.

Statistical Analysis: Bivariate and multivariate logistic regressions were applied to examine the risk factors for SMBG among Saudis with T2DM. …

Bs Information Systems & Business Analytics, 2022-23, Arkansas State University - Jonesboro

Bachelor of Science and Education

No abstract provided.

Bs Biological Science, Eeob 2022-23, Arkansas State University - Jonesboro

Bachelor of Science and Education

Evolution, Ecology & Organismal Biology

Bs Finance - Banking, 2022-23, Arkansas State University - Jonesboro

Bachelor of Science and Education

No abstract provided.

Bs Management, Human Resources 2022-23, Arkansas State University - Jonesboro

Bachelor of Science and Education

No abstract provided.

Bs Global Supply Chain Management, 2022-23, Arkansas State University - Jonesboro

Bachelor of Science and Education

No abstract provided.