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Happiness – Concept, Measurement And Promotion, Yew Kwang Ng

eBooks

While interests in issues pertaining to happiness have been long-standing, we have witnessed recently an increasing focus by both scholars and members of the general public. ‘Subjective well-being (SWB) is an extremely active area of research with about 170,000 articles and books published on the topic in the past 15 years’ (Diener et al. 2018, Abstract). Not only psychologists (e.g. Kahneman et al. 1999, Diener et al. 2010, 2018) and sociologists (e.g. Veenhoven 1984, 1993, 2010, 2017), but also economists have made substantial investigations.1 After about 2–3 decades of gestation since the first publication on happiness issues by an economist …

Maternal Drivers Of Reproductive Output In The Lizard Family Scincidae: A Phylogenetic Comparative Approach, William Zang

West Chester University Master’s Theses

Scincidae is one of the most diverse families of squamates, comprising over 1,300 species of lizards with a variety of life history and ecological traits. This diversity includes three reproductive modes, where some species reproduce via oviparity (egg-laying), viviparity (live birth) or use of a mixed strategy (females switch modes). In this study, it was sought whether reproductive output differs between scincid species using these reproductive modes. Reproductive output is defined as the average product of offspring abundance and size per reproductive event, representing the reproductive effort of an individual. Additionally, the importance of phylogeny (evolutionary relatedness) and a suite …

Providing A Helping Hand: Metabolic Regulation Of T Follicular Helper Cells And Their Association With Disease., Colleen L Mayberry, Natalie A Logan, John J Wilson, Chih-Hao Chang

Faculty Research 2022

T follicular helper (Tfh) cells provide support to B cells upon arrival in the germinal center, and thus are critical for the generation of a robust adaptive immune response. Tfh express specific transcription factors and cellular receptors including Bcl6, CXCR5, PD-1, and ICOS, which are critical for homing and overall function. Generally, the induction of an immune response is tightly regulated. However, deviation during this process can result in harmful autoimmunity or the inability to successfully clear pathogens. Recently, it has been shown that Tfh differentiation, activation, and proliferation may be linked with the cellular metabolic state. In this review …

Editorial: Stromal And Immune Microenvironment In Breast Cancer Metastasis., Xin Lu, Xia Liu, Toni Celià-Terrassa, Guangwen Ren

Faculty Research 2022

No abstract provided.

Epidermal Growth Factor Receptor Inhibition Is Protective In Hyperoxia-Induced Lung Injury., Zachary M Harris, Ying Sun, John Joerns, Brian Clark, Buqu Hu, Asawari Korde, Lokesh Sharma, Hyeon Jun Shin, Edward P Manning, Lindsey Placek, Derya Unutmaz, Gail Stanley, Hyung Chun, Maor Sauler, Govindarajan Rajagopalan, Xuchen Zhang, Min-Jong Kang, Jonathan L Koff

Faculty Research 2022

AIMS: Studies have linked severe hyperoxia, or prolonged exposure to very high oxygen levels, with worse clinical outcomes. This study investigated the role of epidermal growth factor receptor (EGFR) in hyperoxia-induced lung injury at very high oxygen levels (>95%).

RESULTS: Effects of severe hyperoxia (100% oxygen) were studied in mice with genetically inhibited EGFR and wild-type littermates. Despite the established role of EGFR in lung repair, EGFR inhibition led to improved survival and reduced acute lung injury, which prompted an investigation into this protective mechanism. Endothelial EGFR genetic knockout did not confer protection. EGFR inhibition led to decreased levels …

Pharmacokinetic, Pharmacodynamic, And Transcriptomic Analysis Of Chronic Levetiracetam Treatment In 5xfad Mice: A Model-Ad Preclinical Testing Core Study, Kristen D. Onos, Sara K. Quinney, David R. Jones, Andrea R. Masters, Ravi S Pandey, Kelly J Keezer, Carla Biesdorf, Ingrid F. Metzger, Jill A. Meyers, Johnathon Peters, Scott C. Persohn, Brian P. Mccarthy, Amanda A. Bedwell, Lucas L. Figueiredo, Zackary A. Cope, Michael Sasner, Gareth R Howell, Harriet M. Jackson, Adrian L. Oblak, Bruce T. Lamb, Gregory W. Carter, Stacey J. Rizzo, Paul R. Territo

Faculty Research 2022

INTRODUCTION: Hyperexcitability and epileptiform activity are commonplace in Alzheimer's disease (AD) patients and associated with impaired cognitive function. The anti-seizure drug levetiracetam (LEV) is currently being evaluated in clinical trials for ability to reduce epileptiform activity and improve cognitive function in AD. The purpose of our studies was to establish a pharmacokinetic/pharmacodynamic (PK/PD) relationship with LEV in an amyloidogenic mouse model of AD to enable predictive preclinical to clinical translation, using the rigorous preclinical testing pipeline of the Model Organism Development and Evaluation for Late-Onset Alzheimer's Disease Preclinical Testing Core. METHODS: A multi-tier approach was applied that included quality assurance …

Sport Specialization Participants: Motivating Factors And The Impact On Academic Achievement And Emotional Well-Being During And After High School, Michael Wayne Prichard

All-Inclusive List of Electronic Theses and Dissertations

The purpose of this study was to gain an understanding of the phenomenon of sport specialization through the vantage points of participants and the parents of participants. Research questions were related to motivating factors, academic performance, and emotional well-being for the specialized athlete. Participants that passed a screening survey that indicated background knowledge on sport specialization, where they or their child only participated in one sport throughout high school, were chosen for the study. A series of semi-structured interviews took place with participants and parents of participants to acquire a deeper knowledge on the dealings with the sport specialization experience. …

Infant Motor Development Predicts The Dynamics Of Movement During Sleep, Aaron Demasi, Melissa N. Horger, Anat Scher, Sarah E. Berger

Publications and Research

The characteristics of infant sleep change over the first year. Generally, infants wake and move less at night as they grow older. However, acquisition of new motor skills leads to temporary increases in night waking and movement at night. Indeed, sleep-dependent movement at night is important for sensorimotor development. Nevertheless, little is known about how movement during sleep changes as infants accrue locomotor experience. The current study investigated whether infant sleep and movement during sleep were predicted by infants' walking experience. Seventy-eight infants wore an actigraph to measure physical activity during sleep. Parents reported when their infants first walked across …

Importin-Mediated Pathological Tau Nuclear Translocation Causes Disruption Of The Nuclear Lamina, Tdp-43 Mislocalization And Cell Death, Robert F. Candia, Leah S. Cohen, Viktoriya Morozova, Christopher Corbo, Alejandra D. Alonso

Publications and Research

Tau is a cytosolic protein that has also been observed in the nucleus, where it has multiple proposed functions that are regulated by phosphorylation. However, the mechanism underlying the nuclear import of tau is unclear, as is the contribution of nuclear tau to the pathology of tauopathies. We have previously generated a pathological form of tau, PH-tau (pseudophosphorylation mutants S199E, T212E, T231E, and S262E) that mimics AD pathological behavior in cells, Drosophila, and a mouse model. Here, we demonstrated that PH-tau translocates into the nucleus of transiently transfected HEK-293 cells, but wildtype tau does not. We identified a putative …

Unh: The Magazine Of The University Of New Hampshire, Winter 2022, Unh Magazine

UNH Magazine

This editon of UNH Magazine was digital only due to the COVID-19 Pandemic. This is an archived version of web content originally found at https://magazine.unh.edu/

How Adolescents In The Child Welfare System Seek Support For Their Sexual Risk Experiences Online, Taylor L. Moraguez

Honors Undergraduate Theses

Youth in the foster care system experience unique and challenging situations online, such as higher risks of inappropriate messaging (e.g., sexting) and unwanted solicitations from strangers. As a vulnerable group of adolescents, foster youth often use online platforms as a resource to express themselves and seek support over their sexual experiences online. This thesis analyzes how foster youth seek support online for their sexual risk experiences, including sexual abuse, sexting, and sexuality. To understand how adolescents (ages 13-17) in the child welfare system seek support for these experiences, we conducted a thematic analysis of 541 individual posts made by 121 …

Complex Quantum Contagion: A Quantum-Like Approach For The Analysis Of Co-Evolutionary Dynamics Of Social Contagion, Ece Mutlu

Electronic Theses and Dissertations, 2020-2023

Modeling the dynamics of social contagion processes has recently attracted a substantial amount of interest from researchers due to its wide applicability in network science, multi-agent systems, information science, and marketing. Unlike in biological spreading, the existence of a reinforcement effect in social contagion necessitates considering the complexity of individuals in the systems. Although many studies acknowledged the heterogeneity of the individuals in their adoption of information (or behavior), there are no studies that take into account the individuals' uncertainty during their decision-making despite its theoretical and experimental evidence in behavioral economics, decision science, cognitive science, or multi-agent systems. This …

Black Bears In Suburban Areas Consume More Anthropogenic Foods, Alexander Arroyo

IdeaFest 2022

No abstract provided.

What Can Aphasia Tell Us About How The First-Acquired Language Is Instantiated In The Brain?, Mira Goral

Publications and Research

Recent neurolinguistic theories converge on the hypothesis that the languages of multilingual people are processed as one system in the brain. One system for the multiple languages is also at the core of a translanguaging framework of multilingualism—a framework that focuses on each speaker’s complete linguistic repertoire rather than on the separate languages they know. However, evidence from neuroimaging studies suggests at least some nonoverlapping activations of the first-acquired language (L1) and other (non-L1) languages of multilingual people, especially when the age of acquisition and/or levels of proficiency differ across the languages. Neurolinguistic studies of acquired language disorders have demonstrated …

A Computational Study Of The Acidity Of Glufosinate Derivatives, Daniel Sabo

IdeaFest 2022

No abstract provided.

Development And Characterisation Of A Whole Hybrid Sol-Gel Optofluidic Platform For Biosensing Applications, Emma Mchugh, Graceson Antony, Arun Kumar Mallik, Alicja Kaworek, Declan Mccormack, Brendan Duffy, Mohamed Oubaha

Articles

This work outlines, for the first time, the fabrication of a whole hybrid sol-gel optofluidic platform by integrating a microfluidic biosensor platform with optical waveguides employing a standard photolithography process. To demonstrate the suitability of this new hybrid sol-gel optofluidic platform, optical and bio-sensing proof-of-concepts are proposed. A photoreactive hybrid sol-gel material composed of a photopolymerisable organically modified silicon alkoxide and a transition metal complex was prepared and used as the fabrication material for the entire optofluidic platform, including the optical waveguides, the sensing areas, and the microfluidic device. The most suitable sol-gel materials chosen for the fabrication of the …

Does The Thermal Mismatch Hypothesis Predict Disease Outcomes In Different Morphs Of A Terrestrial Salamander?, Matthew D. Venesky, Joseph Demarchi, Cari-Ann M. Hickerson, Carl D. Anthony

2022 Faculty Bibliography

Many aspects of ectotherm physiology are temperature‐dependent. The immune system of temperate‐dwelling ectothermic host species is no exception and their immune function is often down regulated in cold temperatures. Likewise, species of ectothermic pathogens experience temperature‐mediated effects on rates of transmission and/or virulence. Although seemingly straightforward, predicting the outcomes of ectothermic host−pathogen interactions is quite challenging. A recent hypothesis termed the thermal mismatch hypothesis posits that cool‐adapted host species should be most susceptible to pathogen infection during warm temperature periods whereas warm‐adapted host species should be most susceptible to pathogens during periods of cool temperatures. We explore this hypothesis using …

Peroxide Antimalarial Drugs Target Redox Homeostasis In Plasmodium Falciparum Infected Red Blood Cells, Ghizal Siddiqui, Carlo Giannangelo, Amanda De Paoli, Anna Katharina Schuh, Kim C. Heimsch, Dovile Anderson, Timothy G. Brown, Christopher A. Macraild, Jianbo Wu, Xiaofang Wang, Yuxiang Dong, Jonathan L. Vennerstrom, Katja Becker, Darren J. Creek

Journal Articles: Pharmaceutical Sciences

Plasmodium falciparum causes the most lethal form of malaria. Peroxide antimalarials based on artemisinin underpin the frontline treatments for malaria, but artemisinin resistance is rapidly spreading. Synthetic peroxide antimalarials, known as ozonides, are in clinical development and offer a potential alternative. Here, we used chemoproteomics to investigate the protein alkylation targets of artemisinin and ozonide probes, including an analogue of the ozonide clinical candidate, artefenomel. We greatly expanded the list of proteins alkylated by peroxide antimalarials and identified significant enrichment of redox-related proteins for both artemisinins and ozonides. Disrupted redox homeostasis was confirmed by dynamic live imaging of the glutathione …

Emerging Investigator Series: Moving Beyond Resilience By Considering Antifragility In Potable Water Systems, Joseph E. Goodwill, Patrick Ray, Destenie Nock, Christopher M. Miller

Civil & Environmental Engineering Faculty Publications

It is inherently difficult to plan water systems for a future that is non-predictive. This paper introduces a novel perspective for the design and operation of potable water systems under increasing water quality volatility (e.g., a relatively rapid and unpredicted deviation from baseline water quality). Increased water quality volatility and deep uncertainty stress water systems, confound design decisions, and increase the risk of decreased water system performance. Recent emphasis on resilience in drinking water treatment has partly addressed this issue, but still establishes an adversarial relationship with change. An antifragile system benefits from volatile change. By incorporating antifragility, …

Foot Injuries In Michigan, Usa, Gray Wolves (Canis Lupus), 1992–2014, Daniel J. O'Brien, Dean E. Beyer Jr., Erin Largent, Julie R. Melotti, Caitlin N. Ott-Conn, Donald H. Lonsway, Thomas M. Cooley, Robert Atkinson, Michelle Clayson, Kelly A. Straka

United States Department of Agriculture Wildlife Services: Staff Publications

The range of gray wolves (Canis lupus) in the contiguous US is expanding. Research and monitoring to support population recovery and management often involves capture via foothold traps. A population-level epidemiologic assessment of the effect of trap injuries on wolf survival remains needed to inform management. We describe the baseline rate, type, and severity of foot injuries of wolves born 1992–2013 in Michigan’s Upper Peninsula, evaluate the reliability of field-scoring trap-related injuries, and the effect of injuries on wolf survival. We assessed foot injuries by physical and radiographic exam at postmortem and/or time of capture for 351 wolves using the …

Olfactory Lures In Predator Control Do Not Increase Predation Risk To Birds In Areas Of Conservation Concern, Page Klug, Amy A. Yackel Adams, Robert N. Reed

United States Department of Agriculture Wildlife Services: Staff Publications

Context. Lethal control of predators is often undertaken to protect species of conservation concern. Traps are frequently baited to increase capture efficacy, but baited traps can potentially increase predation risk by attracting predators to protected areas. This is especially important if targeted predators can escape capture due to low trap success. Snake traps using live mouse lures may be beneficial if traps effectively remove snakes in the presence of birds and do not attract additional snakes to the area.

Aims. The present study evaluated whether mouse-lure traps in areas occupied by birds (simulated by deploying birdlure traps) could influence predation …

Wild Pig Removal Reduces Pathogenic Bacteria In Low-Order Streams, Sara A. Bolds, B. Graeme Lockaby, Latif Kalin, Stephen S. Ditchkoff, Mark D. Smith, Kurt Vercauteren

United States Department of Agriculture Wildlife Services: Staff Publications

Invasive wild pig populations have undergone enormous increases in the United States and particularly across the southern U.S. in recent years. High fecundity rates and abilities to adapt quickly to varied habitats have enabled pig populations to become entrenched and difficult to eliminate. The pigs cause many negative impacts on ecosystems including degradation of water quality through infusion of fecal contamination and other non-point source pollutants. Our goal was to determine the effects of pig removal on water quality in streams that were known to be significantly polluted by pig activity Bolds (J Environ Qual 50: 441–453, 2021). We compared …

Congressional Myopia In Biomedical Innovation Policy, W. Nicholson Price Ii

Reviews

Innovation policy is hard. Getting it right requires balancing incentives for developers, consumer access, rewards for later innovators, safety concerns, and other factors. This balance is vitally important and wickedly difficult—even when it’s the focus of concerted, careful, informed effort. How well should we expect it to go when innovation policy is made by accident? Enter The Accidental Innovation Policymakers, an illuminating new project by Professor Rachel Sachs. Sachs persuasively shows how Congress has repeatedly made substantial changes to innovation policy, seemingly without talking about, seriously considering, or even recognizing that it is doing so. There’s an asymmetry to this …

Criminal Acts And Basic Moral Equality, John A. Humbach

Elisabeth Haub School of Law Faculty Publications

Modern criminal justice presupposes that persons are not morally equal. On the contrary, those who do wrong are viewed by the law as less worthy of respect, concern and decent treatment: Offenders, it is said, “deserve” to suffer for their misdeeds. Yet, there is scant logical or empirical basis for the law's supposition that offenders are morally inferior. The usual reasoning is that persons who intentionally or knowingly do wrong are the authors and initiators of their acts and, as such, are morally responsible for them. But this reasoning rests on the assumption that a person's mental states, such as …

Uab Magazine - Spring/Summer 2022, University Of Alabama At Birmingham

UAB Magazine

No abstract provided.

Abortion And The Personhood Assumption: A New Defense Of Abortion On The Basis Of Self-Defense, Timothy Kirschenheiter

Wayne State University Dissertations

In this essay, I offer a new defense of abortion. I argue that even if we assume that the fetus is a person with full moral rights abortion is still generally morally permissible. For this argument, I rely on the concept of self-defense, arguing that abortion is morally permissible as a self-defensive action.

In Chapter II, I motivate the personhood assumption by finding and defending the strongest version of Don Marquis’s Future-Like-Ours Argument.

In Chapter III, I argue for the rejection of responsibility arguments in favor of the moral permissibility of abortion – the sort of arguments offered by Judith …

Ecological Predictors Of Sexual Well-Being In Women, Rachel Goutman

Wayne State University Dissertations

Previous research has shown that female sexuality continues to be suppressed in American society and as a result, women are not achieving their highest levels of sexual well-being (i.e., sexual self-concept, sexual assertiveness, and sexual satisfaction). Because sexual well-being is imperative to overall well-being, it is important for counseling psychologists to be sensitive to the potential role that ecological variables have on women’s current sexual well-being. Utilizing an ecological framework, the aims of this study were to deepen our understanding of how early life microsystem experiences relate to later sexual well-being in women, to assess how current macrosystem experiences of …

Childhood Sexual Abuse In Boys Under The Age Of 18: Nonverbal Disclosure Patterns Through Behavior, Matthew J. Luz

The Graduate Review

Adverse childhood experiences (ACE) include being exposed to or victimized by physical, emotional, or sexual abuse; if left untreated, traumas may disrupt normative biopsychosocial development. Childhood sexual abuse (CSA) is a phenomenon investigated by many researchers, however, the scientific community suspects CSA in boys is underreported. Since there are significant gender differences in CSA verbal disclosures, examining nonverbal disclosures in boys through overt, sexualized behaviors may help clinicians confirm suspected cases of CSA. Since most research investigates verbal disclosures of sexual abuse, this study will investigate nonverbal disclosure in boys between the ages of 6 through 10 using naturalistic observations …

Whither The Lofty Goals Of The Environmental Laws?: Can Statutory Directives Restore Purposivism When We Are All Textualists Now?, Stephen M. Johnson

Articles

Congress set ambitious goals to protect public health and the environment when it enacted the federal environmental laws through bipartisan efforts in the 1970s. For many years, the federal courts interpreted the environmental laws to carry out those enacted purposes. Over time, however, courts greatly reduced their focus on the environmental and public health purposes of the environmental laws when interpreting those statutes due to the rise in textualism, the declining influence of the Chevron doctrine, and the increasing willingness of courts to defer to agency underenforcement of statutory responsibilities across all regulatory statutes.

In 2020, the Environmental Protection Network, …

Extending Plasma Proteome Coverage To Enable Biomarker Discovery, Jordan Bruce Burton

Wayne State University Dissertations

Two features make plasma a valued source of health information: First, plasma contains secreted proteins from all tissues in the body and can, therefore, provide information about the health status of all tissues. Second, plasma is available in large quantity using a minimally invasive procedure that is well tolerated. The status of plasma as a valued source of health information is matched by the difficulty in extracting proteome information from the samples. Using state of the art instrumentation a standard analysis of plasma yields quantitative information on approximately 300 proteins. Extreme fractionation strategies coupled with increased mass spectrometry time extends …