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Effects Of In Vivo Exposures To Nanoparticles (Al2O3, Cuo, Tio2) On The Activities Of Atpases In The Gill And Muscle Of Freshwater Mussel (Unio Tigridis), Esi̇n Gülnaz Canli, Mustafa Canli Jan 2022

Effects Of In Vivo Exposures To Nanoparticles (Al2O3, Cuo, Tio2) On The Activities Of Atpases In The Gill And Muscle Of Freshwater Mussel (Unio Tigridis), Esi̇n Gülnaz Canli, Mustafa Canli

Turkish Journal of Zoology

Mussels are effective bioindicator organisms for aquatic environments. Therefore, they were often used to determine the effects of various xenobiotics in the aquatic systems. There is no study to our knowledge on the in vivo effects of nanoparticles (NPs) on the activities of ATPases in freshwater mussels (Unio tigridis). This work demonstrates the effects of Al2O3, CuO, and TiO2 NPs on Na- ATPase, Ca-ATPase, and Mg-ATPase activities in the gill and muscle of mussels following 14-day exposures to different concentrations of NPs (0, 1, 3, 9 mg/L). Mussels were fed with laboratory cultured algae (Chlorella …


The Web Amount And Quality Of Web Spiders (Agelenidae, Pholcidae), Agelena Labyrinthica (Clerck, 1757) And Holocnemus Pluchei (Scopoli, 1763), Depending On Food And Temperature, Bayda Hameed, Adi̇le Akpinar, Derya İşler Ceyhan Jan 2022

The Web Amount And Quality Of Web Spiders (Agelenidae, Pholcidae), Agelena Labyrinthica (Clerck, 1757) And Holocnemus Pluchei (Scopoli, 1763), Depending On Food And Temperature, Bayda Hameed, Adi̇le Akpinar, Derya İşler Ceyhan

Turkish Journal of Zoology

The web amount and quality of web-weaving of two spider species, Agelena labyrinthica (Clerck, 1757) and Holocnemus pluchei (Scopoli, 1763), were determined depending on the temperature and the amount of food consumed. Two different experiments were set up in the study. In the first one, the spiders were raised at different temperatures (20-25 °C and 25-30 °C) under laboratory conditions and they were fed with 10 Drosophila melanogaster (Diptera: Drosophilidae) each time. In the second one, the spiders were fed with 7-10 insects caught from their natural habitats, at 20-25 °C and 25-30 °C. According to this, the difference in …


The Effect Of Ontogenetic Diet Shifts On Sagittal Otolith Shape Of European Perch, Perca Fluviatilis (Actinopterygii: Percidae) From Lake Ladik, Turkey, Oğuz Çöl, Savaş Yilmaz Jan 2022

The Effect Of Ontogenetic Diet Shifts On Sagittal Otolith Shape Of European Perch, Perca Fluviatilis (Actinopterygii: Percidae) From Lake Ladik, Turkey, Oğuz Çöl, Savaş Yilmaz

Turkish Journal of Zoology

European perch undergoes several ontogenetic dietary shifts during its lifetime. The present study focused on the variability in otolith shape caused by ontogenetic dietary changes in this species. A total of 172 specimens (7.5 to 27.5 cm TL) were caught by local fishermen in Lake Ladik from April to November 2019. Shape indices (SIs) and elliptic Fourier coefficients (EFCs) were calculated for each otolith. To detect ontogenetic changes in otolith shape, SIs and EFCs were compared among the three defined size classes (I, II, and III). Size-related groups were distinguished by both SIs and EFCs. Otolith shape analysis was more …


The Microplastic Pattern In Turkish Lakes: Sediment And Bivalve Samples From Çıldır Lake, Almus Dam Lake, And Kartalkaya Dam Lake, Kenan Gedi̇k, Şebnem Atasaral Jan 2022

The Microplastic Pattern In Turkish Lakes: Sediment And Bivalve Samples From Çıldır Lake, Almus Dam Lake, And Kartalkaya Dam Lake, Kenan Gedi̇k, Şebnem Atasaral

Turkish Journal of Zoology

Plastic has become one of the most prominent contaminants in recent decades, posing a major environmental threat with critical implications for seafood safety. Thus, we investigated the abundance and characterization of the microplastics (MPs) in the sediment and bivalves from Çıldır Lake, Almus Dam Lake, and Kartalkaya Dam Lake in Turkey. The abundance of the MPs ranged from 19-156 MP kg$^{-1}$ in the sediments, while 0.75-10.0 MP individual$^{-1}$ (indiv.$^{-1}$) in Anodonta sp., 0.16-1.00 MP indiv.$^{-1}$ in Dreissena polymorpha, 0.50-2.50 indiv.$^{-1}$ in the Unio damescensis was detected. ATR-FTIR was used to identify four distinct polymer types, with polyethylene terephthalate being the …


Contributions On The Southern Distribution Of Vespertilio Murinus Linnaeus, 1758 (Chiroptera: Vespertilionidae) From Türkiye, Ahmet Karataş, Şafak Bulut, Abdurrahman Sefali, Ferhat Toprak, Mehmet Kürşat Şahi̇n, Şaki̇r Önder Özkurt Jan 2022

Contributions On The Southern Distribution Of Vespertilio Murinus Linnaeus, 1758 (Chiroptera: Vespertilionidae) From Türkiye, Ahmet Karataş, Şafak Bulut, Abdurrahman Sefali, Ferhat Toprak, Mehmet Kürşat Şahi̇n, Şaki̇r Önder Özkurt

Turkish Journal of Zoology

Vespertilio murinus Linnaeus, 1758, has a wide distribution from France to Japan, and from Iran in the south to Scandinavia and Russia in the north. The only records of the parti-coloured bat, Vespertilio murinus known from Turkey so far were based on subfossils, remains from owl pellets, and ultrasound recordings. We present the first records of live individuals from two Turkish provinces, Ardahan and Bayburt. Additionally, based on echolocation call records, its known distribution in the Anatolian Peninsula was proved to be wider. The global distribution of the species has been mapped by using ecological niche modelling. The results revealed …


Effects Of Nitrogen Fertilizer On Capoeta Capoeta: An Immunohistopathological And Biochemical Investigation, Seda Vural Aydin, Hasan Özen, Muhi̇tdi̇n Yilmaz Jan 2022

Effects Of Nitrogen Fertilizer On Capoeta Capoeta: An Immunohistopathological And Biochemical Investigation, Seda Vural Aydin, Hasan Özen, Muhi̇tdi̇n Yilmaz

Turkish Journal of Zoology

Increased use of fertilizers to increase plant production causes important environmental pollution not only in soil but also in water resources. Soil structure, water quality, water systems, and biodiversity are adversely affected by the unconscious use of fertilizers. In this study, Capoeta capoeta (Guldenstaedt 1773) were used to investigate the degenerative effects of nitrogen fertilizer. Twentyfour fish were equally allocated into three groups; group 1 (control), group 2 (15 mg/L nitrogen fertilizer in water) and group 3 (15 mg/L nitrogen fertilizer in water). Fish were exposed to the fertilizer for 15 days and then the tissues of gill, liver and …


Contribution To The Aphid Fauna Of The Ordu Province With First Record Of An Exotic Aphid Species, Euceraphis Gillettei Davidson, 1915, In Turkey, Gazi̇ Görür Jan 2022

Contribution To The Aphid Fauna Of The Ordu Province With First Record Of An Exotic Aphid Species, Euceraphis Gillettei Davidson, 1915, In Turkey, Gazi̇ Görür

Turkish Journal of Zoology

During the last 2 decades, aphid species have widely distributed outside their original geographical regions. North America originated Euceraphis gillettei was determined as a new contribution to the Turkey aphid fauna and in turn regarded as an exotic aphid species in Turkey. In addition, all of the determined species are new records for study area. Findings of the present study are in accordance with the predictions made by various aphidologist recently, which it is not going to be a surprise to add more species to the Turkish aphid fauna with a detailed study.


Basic Laboratory And Field Manual For Conducting Research With The Entomopathogenic Nematodes, Steinernema And Heterorhabditis, And Their Bacterial Symbionts, Selçuk Hazir, Harry Kaya, Mustapha Touray, Harun Çi̇men, David Shapiro Ilan Jan 2022

Basic Laboratory And Field Manual For Conducting Research With The Entomopathogenic Nematodes, Steinernema And Heterorhabditis, And Their Bacterial Symbionts, Selçuk Hazir, Harry Kaya, Mustapha Touray, Harun Çi̇men, David Shapiro Ilan

Turkish Journal of Zoology

Broad spectrum chemical pesticides are harmful to humans and other nontarget organisms. Biological control, which entails the use of natural enemies, is a viable alternative. Isolation, identification, and application of biocontrol agents such as the entomopathogenic nematodes (EPNs), Steinernema and Heterorhabditis and their symbiotic bacteria, Xenorhabdus and Photorhabdus have increased substantially over the last four decades, and the trend continues with advancement of molecular techniques. Yet, there is a need for a simple hands-on guide for their proper identification, classification, and handling, especially for researchers and users who are not totally familiar with these biocontrol agents. Thus, this manual is …


Shape Variation In Head Scales Of Species Of The Genus Ophiomorus Duméril & Bibron, 1839 In Iran, A Geometric Morphometrics Approach, Hossein Nabizadeh, Nasrullah Rastegar-Pouyani, Eskandar Rastegar Pouyani, Mehdi Rajabizadeh, Roman Nazarov, Omid Mozaffari Jan 2022

Shape Variation In Head Scales Of Species Of The Genus Ophiomorus Duméril & Bibron, 1839 In Iran, A Geometric Morphometrics Approach, Hossein Nabizadeh, Nasrullah Rastegar-Pouyani, Eskandar Rastegar Pouyani, Mehdi Rajabizadeh, Roman Nazarov, Omid Mozaffari

Turkish Journal of Zoology

Twelve species of the genus Ophiomorus DUMÉRIL & BIBRON, 1839 have been identified and introduced so far and seven species of this genus have been found in Iran which include four endemic species and three nonendemic species. Although geometric morphometry is a powerful tool to analyze morphological changes, the discovery and identification of these species have long relied on traditional morphometric analysis. In this study, geometric morphometric analyses were used to determine the geometric morphometrics of different species of the genus Ophiomorus in Iran. The Multi Focus technique was used to obtain the best image of the dorsal surface of …


Evaluation Of Tea Tree Oil Formulations Contact And Stomach Toxicity Against The Egyptian Cotton Leafworm, Spodoptera Littoralis (Boisduval, 1883) (Lepidoptera: Noctuidae), Şeyda Şi̇mşek, Ayhan Gökçe, Errol Hassan Jan 2022

Evaluation Of Tea Tree Oil Formulations Contact And Stomach Toxicity Against The Egyptian Cotton Leafworm, Spodoptera Littoralis (Boisduval, 1883) (Lepidoptera: Noctuidae), Şeyda Şi̇mşek, Ayhan Gökçe, Errol Hassan

Turkish Journal of Zoology

The insecticidal potential of tea tree oil formulations was tested for contact and stomach poison toxicities against various stages of the Spodoptera littoralis ((Boisduval, 1883) (Lepidoptera: Noctuidae) larvae under laboratory conditions. The study was carried out at Yozgat Bozok University Faculty of Agriculture between 2020 and 2021. In the contact toxicity test, the formulations were tested at different stages of larvae by topical application. Among the tested formulations, TTO (100%), F14 (91.72%), and F15 (89.20%) formulations caused the highest mortality in the S. littoralis 3rd stage larvae after 72 h. Dose-response bioassay with the most promising formulations (TTO, F14 and …


New Insights On The Impact Of Earthworm Extract On The Growth Of Beneficial Soil Fungi: Species-Specific Alteration Of The Nematophagous Fungal Growth And Limitation Of An Entomopathogenic Fungus, Maryam Chelkha, Lamia Yakkou, Sofia Houida, Mohamed Raouane, Souad Amghar, Raquel Campos-Herrera, Abdellatif El Harti Jan 2022

New Insights On The Impact Of Earthworm Extract On The Growth Of Beneficial Soil Fungi: Species-Specific Alteration Of The Nematophagous Fungal Growth And Limitation Of An Entomopathogenic Fungus, Maryam Chelkha, Lamia Yakkou, Sofia Houida, Mohamed Raouane, Souad Amghar, Raquel Campos-Herrera, Abdellatif El Harti

Turkish Journal of Zoology

Earthworms influence soil ecosystem functions such as decomposition and regulation of nutrient cycles by burrowing, feeding, or secreting their cutaneous excreta. Earthworms can also modulate soil biodiversity and their interactions. Recent research has revealed that earthworm feeding activity or excretions can alter the performance of entomopathogenic nematodes (EPNs) and entomopathogenic fungi (EPFs), known biological control agents. Still, the impact of earthworm cadavers on the growth and reproduction of other biological control agents such as nematophagous fungus (NFs) and EPFs has been poorly explored. We suggest that earthworm body tissue could be used as a food supply by certain fungal species. …


Body Condition Of Three Autochthonous Canid Species From Serbia, Aleksandra Penezic, Milica Kurucki, Neda Bogdanovic, Ilija Pantelic, Dusko Cirovic Jan 2022

Body Condition Of Three Autochthonous Canid Species From Serbia, Aleksandra Penezic, Milica Kurucki, Neda Bogdanovic, Ilija Pantelic, Dusko Cirovic

Turkish Journal of Zoology

The body condition of three autochthonous canid species in Serbia (wolf- Canis lupus, jackal-Canis aureus, and fox-Vulpes vulpes) was assessed based on the value of Kidney Fat Index (KFI). A total of 1232 specimens (147 wolves, 711 jackals, and 375 foxes) were collected during a ten years period. Data were analyzed according to multiple factors such as sex, age, seasons, species, and genus. The results indicate that the adult members of the Canis genus have a significantly better body conditional status than the yearlings as well as the representatives of the Vulpes genus (F (2, …


Freshwater Lamprey And Fishes Of Iran; A Revised And Updated Annotated Checklist-2022, Soheil Eagderi, Atta Mouludi-Saleh, Hamid Riza Esmaeli, Golnaz Sayyadzadeh, Manonchehr Nasri Jan 2022

Freshwater Lamprey And Fishes Of Iran; A Revised And Updated Annotated Checklist-2022, Soheil Eagderi, Atta Mouludi-Saleh, Hamid Riza Esmaeli, Golnaz Sayyadzadeh, Manonchehr Nasri

Turkish Journal of Zoology

The current status of the inland waters ichthyofauna of Iran is revised and updated. A total of 292 fish species belong to 3 classes, 24 orders, 36 families and 106 genera inhabit the inland waters of Iran. Among these, 29 species (9.9%) are exotic and 102 species (35%) are endemic. Orders with the largest numbers of species in the ichthyofauna of Iran are the Cypriniformes (182 species) followed by Gobiiformes (30 species), Cyprinodontiformes (15 species), Siluriformes (12 species), Clupeiformes (10 species), Acipenseriformes and Cichliformes (7 species) and Mugiliformes (6 species). At the family level, the Cyprinidae has the greatest number …


Spatiotemporal And Bioecological Distribution Of Four Commercial Mullid Species In An Ultraoligotrophic Mediterranean Gulf, Erhan Mutlu, Claudia Miglietta, Ilaria De Meo, Mehmet Cengi̇z Deval Jan 2022

Spatiotemporal And Bioecological Distribution Of Four Commercial Mullid Species In An Ultraoligotrophic Mediterranean Gulf, Erhan Mutlu, Claudia Miglietta, Ilaria De Meo, Mehmet Cengi̇z Deval

Turkish Journal of Zoology

This study provides baseline data on the mullid fish assemblages based on their morphometries on a shelf of the most oligotrophic water of the Mediterranean Sea, Antalya Gulf. The distribution of fish abundances, biomasses, total length, sex composition, growth parameters, and ecological fish assemblages was studied along three transects (each had a series of bottom depths of 10, 25, 75, 125, and 200 m) between spring 2014 and winter 2015, representing the winter, spring, summer and autumn seasons. Four different species of the Mullidae family: the red mullet (Mullus barbatus), the striped red mullet (M. surmuletus), …


Berry Anthocyanin, Acid, And Volatile Trait Analyses In A Grapevine-Interspecific F2 Population Using An Integrated Gbs And Rhampseq Genetic Map, Dilmini Alahakoon, Anne Fennell, Zachary Helget, Terry Bates, Avainash Karn, David Manns, Anna Katherine Mansfield, Bruce I. Reisch, Gavin Sacks, Qi Sun, Cheng Zou, Lance Cadle-Dvidson, Jason P. Londo Jan 2022

Berry Anthocyanin, Acid, And Volatile Trait Analyses In A Grapevine-Interspecific F2 Population Using An Integrated Gbs And Rhampseq Genetic Map, Dilmini Alahakoon, Anne Fennell, Zachary Helget, Terry Bates, Avainash Karn, David Manns, Anna Katherine Mansfield, Bruce I. Reisch, Gavin Sacks, Qi Sun, Cheng Zou, Lance Cadle-Dvidson, Jason P. Londo

Agronomy, Horticulture and Plant Science Faculty Publications

Increased map density and transferability of markers are essential for the genetic analysis of fruit quality and stress tolerance in interspecific grapevine populations. We used 1449 GBS and 2000 rhAmpSeq markers to develop a dense map for an interspecific F2 population (VRS-F2) that was derived by selfing a single F1 from a Vitis riparia x ‘Seyval blanc’ cross. The resultant map contained 2519 markers spanning 1131.3 cM and was highly collinear with the Vitis vinifera ‘PN40024’ genome. Quantitative trait loci (QTL) for berry skin color and flower type were used to validate the map. Four rhAmpSeq …


Division Of Research And Economic Development Annual Report For Fy2022, Uri Division Of Research And Economic Development Jan 2022

Division Of Research And Economic Development Annual Report For Fy2022, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

Annual report for the Division of Research and Economic Development of the University of Rhode Island for the year 2021-2022.

Includes statistics of project proposals, expenditures, URI Foundation Awards, previous annual report summaries and awards received by individual academic and administrative departments.


Momentum: Research & Innovation For Fall 2022, University Of Rhode Island Jan 2022

Momentum: Research & Innovation For Fall 2022, University Of Rhode Island

Publications (Research and Economic Development)

The Fall 2022 issue of Research & Innovation, a periodical focused on research at the University of Rhode Island.


Momentum: Research & Innovation For Spring 2022, University Of Rhode Island Jan 2022

Momentum: Research & Innovation For Spring 2022, University Of Rhode Island

Publications (Research and Economic Development)

The Spring 2022 issue of Research & Innovation, a periodical focused on research at the University of Rhode Island.


Formulation, Characterisation And Evaluation Of The Antihypertensive Peptides, Isoleucine-Proline-Proline And Leucine-Lysine-Proline In Chitosan Nanoparticles Coated With Zein For Oral Drug Delivery, Minna Khalid Danish, John P. Gleeson, David J. Brayden, Hugh Byrne, Jesus Maria Frias, Sinead Ryan Jan 2022

Formulation, Characterisation And Evaluation Of The Antihypertensive Peptides, Isoleucine-Proline-Proline And Leucine-Lysine-Proline In Chitosan Nanoparticles Coated With Zein For Oral Drug Delivery, Minna Khalid Danish, John P. Gleeson, David J. Brayden, Hugh Byrne, Jesus Maria Frias, Sinead Ryan

Articles

Isoleucine-Proline-Proline (IPP) and Leucine-Lysine-Proline (LKP) are food-derived tripeptides whose antihypertensive functions have been demonstrated in hypertensive rat models. However, peptides display low oral bioavailability due to poor intestinal epithelial permeability and instability. IPP and LKP were formulated into nanoparticles (NP) using chitosan (CL113) via ionotropic gelation and then coated with zein. Following addition of zein, a high encapsulation efficiency (EE) (>80%) was obtained for the NP. In simulated gastric fluid (SGF), 20% cumulative release of the peptides was achieved after 2 h, whereas in simulated intestinal fluid (SIF), ~90% cumulative release was observed after 6 h. Higher colloidal stability …


Hydrogel On A Smart Nanomaterial Interface To Carry Therapeutics For Digitalized Glioma Treatment, Xinyi Zhao, Bilal Javed, Furong Tian, Kangze Liu Jan 2022

Hydrogel On A Smart Nanomaterial Interface To Carry Therapeutics For Digitalized Glioma Treatment, Xinyi Zhao, Bilal Javed, Furong Tian, Kangze Liu

Articles

Glioma is considered the primary brain tumor to cause brain illnesses, and it is difficult to treat and shows resistance to various routine therapeutics. The most common treatments to cure glioma are the surgical removal of tumors followed by adjuvant chemotherapy and radiation therapy. The latest biocompatible interfaces have been incorporated into therapeutic modalities such as the targeted delivery of drugs using hydrogels to treat and manage brain glioma. This review illustrates the applications of the multimodal hydrogel as the carrier of therapeutics, gene therapy, therapeutic tactics, and glioma devices. The scientific articles were retrieved from 2019 to 2022 on …


Cold Plasma Technology In Food Packaging, Kalpani Perera, Jack Prendeville, Amit Jaiswal, Swarna Jaiswal Jan 2022

Cold Plasma Technology In Food Packaging, Kalpani Perera, Jack Prendeville, Amit Jaiswal, Swarna Jaiswal

Articles

Cold plasma (CP) is an effective strategy to alter the limitations of biopolymer materials for food packaging applications. Biopolymers such as polysaccharides and proteins are known to be sustainable materials with excellent film-forming properties. Bio-based films can be used as an alternative to traditional plastic packaging. There are limitations to biopolymer packaging materials such as hydrophobicity, poor barrier, and thermos-mechanical properties. For this reason, biopolymers must be modified to create a packaging material with the desired applicability. CP is an effective method to enhance the functionality and interfacial features of biopolymers. It etches the film surface allowing for better adhesion …


Exploring The Concept Of The Digital Educator During Covid-19, Fernando Jimenez, Gracia Sanchez, Jose Palma, Luis Miralles-Pechuán, Juan A. Botia Jan 2022

Exploring The Concept Of The Digital Educator During Covid-19, Fernando Jimenez, Gracia Sanchez, Jose Palma, Luis Miralles-Pechuán, Juan A. Botia

Articles

T In many machine learning classification problems, datasets are usually of high dimensionality and therefore require efficient and effective methods for identifying the relative importance of their attributes, eliminating the redundant and irrelevant ones. Due to the huge size of the search space of the possible solutions, the attribute subset evaluation feature selection methods are not very suitable, so in these scenarios feature ranking methods are used. Most of the feature ranking methods described in the literature are univariate methods, which do not detect interactions between factors. In this paper, we propose two new multivariate feature ranking methods based on …


Comparison Of Vibrational Spectroscopic Techniques For Quantification Of Water In Natural Deep Eutectic Solvents, Suha Elderderi, Pierre-Yves Sacré, Laura Wils, Igor Chourpa, Abdalla A. Elbashir, Philippe Hubert, Hugh Byrne, Leslie Boudesocque-Delaye, Eric Ziemons, Franck Bonnier Franck Bonnier Jan 2022

Comparison Of Vibrational Spectroscopic Techniques For Quantification Of Water In Natural Deep Eutectic Solvents, Suha Elderderi, Pierre-Yves Sacré, Laura Wils, Igor Chourpa, Abdalla A. Elbashir, Philippe Hubert, Hugh Byrne, Leslie Boudesocque-Delaye, Eric Ziemons, Franck Bonnier Franck Bonnier

Articles

Vibrational spectroscopic techniques, i.e., attenuated total reflectance infrared (ATRIR), near infrared spectroscopy (NIRS) and Raman spectroscopy (RS), coupled with Partial Least Squares Regression (PLSR), were evaluated as cost-effective label-free and reagent-free tools to monitor water content in Levulinic Acid/L-Proline (LALP) (2:1, mol/mol) Natural Deep Eutectic Solvent (NADES). ATR-IR delivered the best outcome of Root Mean Squared Error (RMSE) of Cross- Validation (CV) = 0.27% added water concentration, RMSE of Prediction (P) = 0.27% added water concentration and mean % relative error = 2.59%. Two NIRS instruments (benchtop and handheld) were also compared during the study, respectively yielding RMSECV = 0.35% …


Evaluation Of Cell-Matrix Interactions In K14+ Leader Cells On Caf-Modulated Matrix, Trey P. Redman, Jessanne Y. Lichtenberg, Priscilla Y. Hwang Jan 2022

Evaluation Of Cell-Matrix Interactions In K14+ Leader Cells On Caf-Modulated Matrix, Trey P. Redman, Jessanne Y. Lichtenberg, Priscilla Y. Hwang

Summer REU Program

No abstract provided.


Nonpharmacological Practices For Reducing Agitation In Persons With Dementia, Meghan L. Farkas Jan 2022

Nonpharmacological Practices For Reducing Agitation In Persons With Dementia, Meghan L. Farkas

Commonwealth Scholars Program

1 in 11 people aged 45 years and older experience subjective cognitive decline, with nearly a third identifying a decline in the ability to participate in social activities, work, or volunteering. There are twelve modifiable risk factors that can either increase or decrease an individual's possibility of developing Dementia. This can include excessive alcohol consumption, head injury, air pollution, lower education level, hypertension, hearing impairment, smoking, obesity, depression, physical inactivity, diabetes, and infrequent social contact. These modifiable risk factors may prevent or delay up to 40% of dementias. Furthermore, many risk factors cluster around inequalities, which occur particularly in Black, …


Coping With Macular Degeneration: Three Case Studies, Ajit D. Tiwari Jan 2022

Coping With Macular Degeneration: Three Case Studies, Ajit D. Tiwari

Case Studies from Age in Action

Educational Objectives

1. Learn about the diagnosis and available treatments for Age Related Macular Degeneration (AMD).

2. Explain the differences between Dry and Wet AMD.

3. Understand the impact of vision loss on the lives of older adults.


Aurintricarboxylic Acid Is A Canonical Disruptor Of The Taz-Tead Transcriptional Complex, Kepeng Che, Ajaybabu V. Pobbati, Caleb N. Seavey, Yuriy Fedorov, Anton A. Komar, Ashley Burtscher, Shuang Ma, Brian P. Rubin Jan 2022

Aurintricarboxylic Acid Is A Canonical Disruptor Of The Taz-Tead Transcriptional Complex, Kepeng Che, Ajaybabu V. Pobbati, Caleb N. Seavey, Yuriy Fedorov, Anton A. Komar, Ashley Burtscher, Shuang Ma, Brian P. Rubin

Biological, Geological, and Environmental Faculty Publications

Disrupting the formation of the oncogenic YAP/TAZ-TEAD transcriptional complex holds substantial therapeutic potential. However, the three protein interaction interfaces of this complex cannot be easily disrupted using small molecules. Here, we report that the pharmacologically active small molecule aurintricarboxylic acid (ATA) acts as a disruptor of the TAZ-TEAD complex. ATA was identified in a high-throughput screen using a TAZ-TEAD AlphaLISA assay that was tailored to identify disruptors of this transcriptional complex. We further used fluorescence polarization assays both to confirm disruption of the TAZ-TEAD complex and to demonstrate that ATA binds to interface 3. We have previously shown that cell-based …


Thei Student Applied Research Presentations Sarp 2022, Research Office Thei Jan 2022

Thei Student Applied Research Presentations Sarp 2022, Research Office Thei

THEi Student Applied Research Presentations (SARP)

No abstract provided.


The Drosophila Mutagen-Sensitivity Gene Mus109 Encodes Dmdna2, Chandani Mitchell, Vada Becker, Jordan Deloach, Erica Nestore, Elyse Bolterstein, Kathryn P. Kohl Jan 2022

The Drosophila Mutagen-Sensitivity Gene Mus109 Encodes Dmdna2, Chandani Mitchell, Vada Becker, Jordan Deloach, Erica Nestore, Elyse Bolterstein, Kathryn P. Kohl

Biology Faculty Publications

The development of gene mapping techniques has a long and storied history in the Drosophila melanogaster model system (reviewed in [1]), beginning with Alfred Sturtevant’s fundamental publication of the first genetic map in 1913 [2]. In this work, Sturtevant showed that genes are arranged in a linear order along chromosomes and that the recombination frequency between two genes could be used as a measure of the distance between them. This discovery created the foundation for other key advances in Drosophila gene mapping, including the generation of detailed polytene chromosome cytogenetic maps [3,4], the development of deletion kits covering the genome …


People-Powered Research And Experiential Learning: Unravelling Hidden Biodiversity, Melanie Pivarski, Matt Von Konrat, Tom Campbell, Numerous Other Co-Authors Jan 2022

People-Powered Research And Experiential Learning: Unravelling Hidden Biodiversity, Melanie Pivarski, Matt Von Konrat, Tom Campbell, Numerous Other Co-Authors

Biology Faculty Publications

Globally, thousands of institutions house nearly three billion scientific collections offering unparallelled resources that contribute to both science and society. For herbaria alone - facilities housing dried plant collections - there are over 3,000 herbaria worldwide with an estimated 350 million specimens that have been collected over the past four centuries. Digitisation has greatly enhanced the use of herbarium data in scientific research, impacting diverse research areas, including biodiversity informatics, global climate change, analyses using next-generation sequencing technologies and many others. Despite the entrance of herbaria into a new era with enhanced scientific, educational and societal relevance, museum specimens remain …