Digital Commons Network^™

Human Endogenous Retrovirus Type K Promotes Proliferation And Confers Sensitivity To Anti-Retroviral Drugs In Merlin-Negative Schwannoma And Meningioma., Emmanuel A. Maze, Bora Agit, Shona Reeves, David A. Hilton, David B. Parkinson, Liyam Laraba, Emanuela Ercolano, Kathreena M. Kurian, C. Oliver Hanemann, Robert D. Belshaw, Sylwia Ammoun

Peninsula Medical School

Deficiency of the tumor suppressor Merlin causes development of schwannoma, meningioma, and ependymoma tumors, which can occur spontaneously or in the hereditary disease neurofibromatosis type 2 (NF2). Merlin mutations are also relevant in a variety of other tumors. Surgery and radiotherapy are current first-line treatments; however, tumors frequently recur with limited treatment options. Here, we use human Merlin-negative schwannoma and meningioma primary cells to investigate the involvement of the endogenous retrovirus HERV-K in tumor development. HERV-K proteins previously implicated in tumorigenesis were overexpressed in schwannoma and all meningioma grades, and disease-associated CRL4DCAF1 and YAP/TEAD pathways were implicated in this overexpression. …

Do Micronutrient And Omega-3 Fatty Acid Supplements Affect Human Maternal Immunity During Pregnancy? A Scoping Review, G Rees, L Brough, Gm Orsatti, A Lodge, S Walker

School of Biomedical Sciences

Maternal dietary micronutrients and omega-3 fatty acids support development of the fetal and neonatal immune system. Whether supplementation is similarly beneficial for the mother during gestation has received limited attention. A scoping review of human trials was conducted looking for evidence of biochemical, genomic, and clinical effects of supplementation on the maternal immune system. The authors explored the literature on PubMed, Cochrane Library, and Web of Science databases from 2010 to the present day using PRISMA-ScR methodology. Full-length human trials in English were searched for using general terms and vitamin A, B12, C, D, and E; choline; iodine; iron; selenium; …

Usage Of E-Resources By The Users Of The Agricultural University Libraries In India, Monisha Mishra, Dr. Krushna Chandra Panda

Library Philosophy and Practice (e-journal)

This paper, a part of the author’s doctoral research, examines the various e-resources to which the users of Agricultural Universities in India have access and how frequently these resources are being used by agricultural scientists, researchers, students. Data collected through a structured questionnaire from 242 users and 20 Librarians from 20 State-run Agricultural Universities in India constitute the database for the present investigation. Additionally, the study also investigates the membership of various consortiums availed by the users and whether the respondents have access to some of the key e-resources of other institutions including frequency of usage of subject gateways, blogs …

Clonal Hematopoiesis Mutations In Patients With Lung Cancer Are Associated With Lung Cancer Risk Factors, Wei Hong, Ang Li, Yanhong Liu, Xiangjun Xiao, David C Christiani, Rayjean J Hung, James Mckay, John Field, Christopher I Amos, Chao Cheng

Faculty, Staff and Students Publications

Clonal hematopoiesis (CH) is a phenomenon caused by expansion of white blood cells descended from a single hematopoietic stem cell. While CH can be associated with leukemia and some solid tumors, the relationship between CH and lung cancer remains largely unknown. To help clarify this relationship, we analyzed whole-exome sequencing (WES) data from 1,958 lung cancer cases and controls. Potential CH mutations were identified by a set of hierarchical filtering criteria in different exonic regions, and the associations between the number of CH mutations and clinical traits were investigated. Family history of lung cancer (FHLC) may exert diverse influences on …

Analysis Of Ensiling Suitability Of Moringa, A Woody Plant, Z. Du, F. Yang, Y. Lin, Y. Cai

IGC Proceedings (1977-2023)

To effectively use the woody plant resources as animal feed, the ensiling suitability of Moringa including the dynamics of microbial community, chemical composition, and silage fermentation were studied. Tender stems and leaves of Moringa at the full-bloom stage of second cutting was used for silage preparation in Guizhou, China. After 3, 7, 15, 30, and 60 days of ensiling, five silos for each treatment were opened to analyze the fermentation characteristics. Moringa before ensiling contained 10⁴ lactic acid bacteria (LAB), 10⁶ aerobic bacteria, 10⁴ coliform bacteria, 10² yeast, and 10⁴ mold based on colony-forming unit/g …

Impact Of Grazing Management On Productivity Of Tropical Grasslands, Moacyr Corsi, Geraldo B. Martha Jr., Domício Do Nascimento Jr., Marco A. A. Balsalobre

IGC Proceedings (1977-2023)

Beef and dairy cattle enterprises from tropical pasture-based systems are notoriously of low productivity. The low soil fertility, the exploitation of native grasslands, the low genetic potential of the animals and the poor management of soil, pasture and animal components are all arguments used to explain these “low-productivity systems”. In fact, research has consistently indicated up to 50% increase in calving rate when animals grazing unfertilized pastures were supplemented with trace-mineralized salt (Table 1) but unfortunately less than 90% of Brazilian farmers use this management strategy (Tosi, 1997). However, a recent survey conducted by São Paulo State government showed that …

Impact Of Grazing Management On The Productivity Of Cold Temperate Grasslands Of Southern Patagonia - A Critical Assessment, A. F. Cibils, M. B. Coughenour

IGC Proceedings (1977-2023)

The contention that productivity of cold temperate grasslands of southern Patagonia have been greatly affected by domestic herbivore grazing in the past is fairly widespread. The consequences of spatiotemporal interactions between grazing and abiotic factors on the overall productivity of such systems, however, are still poorly understood. Predictions of both short- and long-term impacts of grazing management strategies on grassland productivity require a better understanding of these interactions. In this paper we make a critical assessment of the impact of grazing management on long-term sustainability of the grass steppes of southern Patagonia (Argentina). We discuss this issue in the context …

Productivity Of Winter And Spring Native Improved Vegetation Under Different Grazing Stocking Rates On Basaltic Soil, M. Bemhaja

IGC Proceedings (1977-2023)

Improved grassland with Lotus corniculatus, Trifolium repens and annual phosphorus fertilization, was evaluated during winter and spring for five consecutive years under grazing at three different stocking rates on medium basaltic soil. Specific contribution of Lotus and Trifolium reached 67% of grassland community in the first year. Stipa setigera and Poa lanigera increased their contribution from 0.8 to 17% in the fourth year of grazing experiment. Highest average value of crude protein was 19% during the second year and was related to legumes contribution. Forage availability was always up to 1.5 ton MS/ha at the three stocking treatments. Average daily …

Effects Of Cattle Grazing On A Perennial Legume, Bitumen Trefoil (Bituminaria Bituminosa (L.) Stirton), In A Mediterranean Grassland, M. Gutman, M. Sternberg, A. Perevoltsky

IGC Proceedings (1977-2023)

A six-year study was conducted in a Mediterranean grassland in north-eastern Israel to investigate the effects of cattle grazing management on a perennial legume, Bitumen Trefoil (Bituminaria bituminosa (L.) Stirton). The relationship between grazing pressure and its relative plant cover was studied in the context of inter-annual variation in rainfall. Treatments included manipulations of stocking rates (moderate, heavy and very heavy) and of grazing regimes (continuous vs. seasonal), in a factorial design. The results showed that inter-seasonal rainfall variation was a dominant factor in the expression of plant cover changes of this species. Grazing showed no significant effect on …

Performance Comparison Of Residual Control Charts For A Count Data Based On Ridge Regression, Shaimaa Mohamed Yassin, Salah M. Mohamed

Information Sciences Letters

Regression models are important and widely used tools to design relationships between pairs of endogenous and exogenous variables. However, they usually suffer from multicollinearity. This study uses residual control charts on count data (Poisson regression), after resolve multicollinearity problems by utilizing the ridge technique. Residual control charts with Poisson regression were introduced by Filho [1], who employed the principal component to treat the multicollinearity problem and, thereafter, prepared a control chart. However, we selected average run length as the metric for the evaluation of the control chart. We used simulated data and application using real data on water quality. The …

A New Generalization Of The Gumbel Distribution With Climate Application, Hussein Eledum, Mohammed Ahmmed Mosilhy

Information Sciences Letters

In this paper, we propose a new generalization of the Gumbel distribution named the Cubic Transmuted Gumbel distribution (CTGD) based on a cubic ranking transmutation map. Statistical properties of CTGD such as reliability function, hazard function, moments, moment generating function, quantile function, and simulation of the random sample are studied. The parameters of CTGD are estimated using the Maximum Likelihood method. Finally, an application of CTGD using two real data sets on climate change is conducted to illustrate and compare with the base Gumbel distribution (GD) and transmuted Gumbel distribution (TGD). CTGD was found to be a better fit than …

A New View Of Special Types Of Subgraphs With Applications On Circulation Of Hepatic Portal System, M. S. El Azab, M. Shokry, Reham Emad Aly

Information Sciences Letters

Fuzzy graph theory has enormous range of applications in neural networks, physical, logic, algebra, topology, operations research, pattern recognition, artificial intelligence, natural and sociobiological sciences and in several other areas. We propose new concepts for generating different types of fuzzy subgraph defined as κ􏰂1κ􏰂2 - fuzzy subgraph which depend on the changeable of the memberships of vertices and edges with discussing new type of paths Pκ􏰂1κ􏰂2 . Our approach is based on studying its effect of strength on different types of arcs by explaining several examples and deducing new important properties. Finally, we demonstrate all of the above on the …

Benefit-Cost Analysis Of Flood Management, A Case Study Of Jammu And Kashmir, Kowser Ali Jan, R. Balaji, Khairi Mohamad Omar

Information Sciences Letters

This paper focuses on the cost-benefit analysis (CBA) of flood management by District Disaster Management Kulgam. The assessment is based on secondary pooled data collected from government offices, NGOs, journals, and national newspapers. We describe the scenario, the approach adopted, and sources of flood damage cost information. The estimated total benefits account for 78686.18 lakh rupees, and total costs account for 2218.75lakh rupees. The Benefit-Cost ratio greater than one shows that Flood Management in District Kulgam was economically feasible and successfully managed. The State of Jammu and Kashmir takes essential prevention and management measures to bring down the damages due …

The Mechanism Of Charge Flow And Electric Current In Porous Gan Thin Films During Photo Electrochemical Etching, K. Al-Heuseen, A.I. Aljameel, M. Kh. Alquran

International Journal of Thin Film Science and Technology

In this work nano-porous structures of n-GaN was fabricated using simple photoelectrochemical etching techniques. The electrolyte was H2SO4:H2O2 under direct current density of 5 mA/cm2 for 30 min. Scanning electron microscopy (SEM) has been used to studied the morphology, the size, and the shape of the pores of n-GaN nanostructures. The mechanism of charge and current flow in photoelectrochemical etching process was investigated deeply. The electrical and chemical behaviour of the electrolyte-GaN junction has been studied. The energy diagram of an n-GaN and the electrolyte was used to illustrate the charges flow mechanism. A simple model depend on two parallel …

Electrical And Optical Properties Of Flexible Transparent Silver Nanowires Electrodes, Rabeea D. Abdel-Rahim, Adham M. Nagiub, Mahmoud A. Taher

International Journal of Thin Film Science and Technology

AgNWs were produced by the one-pot polyol method, and it had been produced by reduction of AgNO3 by ethylene glycol in presence of polyvinylpyrrolidone (PVP) and KCl at high temperature of about 160 oC. AgNWs suspension were purified by centrifuging at 3000 rpm for three times then re-depressed in deionized water with a concentration of 1%. The purified suspension was diluted to different concentrations (2-5) mg. mL-1 using 1% of hydroxy methylcellulose to design different AgNWs transparent conductive films (AgNWs-TCFs). AgNWs suspension inks were coated on the glass and polyethylene terephthalate (PET) substrates. Different AgNWs diameters were obtained by changing …

Real Time Face Authentication System Using Stacked Deep Auto Encoder For Facial Reconstruction, Showkat A. Dar, S. Palanivel

International Journal of Thin Film Science and Technology

Any human being has unique biological traits biological characteristics which can be studied using Biometrics which encompasses an individuals characteristics like DNA, face, finger prints, voice, signatures etc. Human faces as an element of authentication are being increasingly used where biometrics add value in terms of quantifying an individual’s natural data. Facial authentications validate personal identities based on facial images with 1-1 matches. These kinds of authenticating applications have been applied in a variety of areas including banking applications and personal mobile devices. RTFAs (Real Time Face Authentications) based systems are a necessity for ATMs (Automated Teller Machines) in banking …

Effect Of Annealing Based On The Structural, Optical, Morphological And Antibacterial Activities Of Copper Oxide Thin Films By Silar Technique, K. Dhanabalan, A.T. Ravichandran, A.Vasuhi, R. Chandramohan, P. Karthick, Srinivas Mantha

International Journal of Thin Film Science and Technology

Copper oxide thin films were deposited onto a glass substrate using Successive Ionic Layer Adsorption and Reaction (SILAR) method. The structural, optical, surface morphology, and antibacterial activities are studied. The structural studies revealed that the as-deposited and annealed film at different temperatures like 150 °C, 200 °C, and 250 °C. The preferential orientations of all films are (111) plane with the cubic system. The XRD patterns are well-matched with JCPDS card No: 05-0667. From the UV-vis-NIR studies, the transmittance and absorbance of the film are increased with the increase of annealing temperature. It can attain a maximum temperature of 250 …

Hmong Parent Day/Hnub Txhawb Nqa Niam Txiv: Implementing Psychosociocultural Educational Programming To Honor Rau Siab, Pa Her, Alberta M. Gloria, Shee Yee Chang, Pahoua Thao

Journal of Southeast Asian American Education and Advancement

This paper describes the interrelated conceptual activities that took a Psychosociocultural (PSC) approach to direct best practices, interactions, and processes to implement HMong Parent Days effectively. The purpose of HMong Parent Day/ Hnub Txhawb Nqa Niam Txiv, a culturally-centered community-focused intervention, was to bring HMong parents onto a midwestern predominantly White university campus for a day of college knowledge. The day honored HMong parents' support of their children into and through higher education via the cultural value of rau siab (hard work). Three levels of learning that emergent as new knowledge for HMong parents were highlighted and discussed relative to …

Jmu Libraries Magazine, Jenne M. Klotz, Kristen S. Shuyler, Emily D. Blake

Libraries

This magazine describes highlights from the JMU Libraries from 2020-2021.

Data-Driven Modeling Predicts Gene Regulatory Network Dynamics During The Differentiation Of Multipotential Hematopoietic Progenitors, Joanna Handzlik, Manu

Biology Faculty Publications

Cellular differentiation during hematopoiesis is guided by gene regulatory networks (GRNs) comprising transcription factors (TFs) and the effectors of cytokine signaling. Based largely on analyses conducted at steady state, these GRNs are thought to be organized as a hierarchy of bistable switches, with antagonism between Gata1 and PU.1 driving red- and white-blood cell differentiation. Here, we utilize transient gene expression patterns to infer the genetic architecture—the type and strength of regulatory interconnections—and dynamics of a twelve-gene GRN including key TFs and cytokine receptors. We trained gene circuits, dynamical models that learn genetic architecture, on high temporal-resolution gene-expression data from the …

Rehabilitation/Recovery Journals, Judy Schmitt

Library Faculty Works

Comprehensive list of rehabilitation/recovery journals

Impact Of Pooling Samples On Analytic Sensitivity Of A Real-Time Reverse Transcriptase Pcr Assay For Sars Cov-2, Subathra Marimuthu, Stephen P. Furmanek, Holly Aliesky, Leslie A. Wolf

The University of Louisville Journal of Respiratory Infections

During the COVID-19 pandemic, laboratories experienced periods of shortages for certain critical materials required to meet the high demand for SARS-CoV-2 testing. The U.S. Food & Drug Administration provided a template for molecular diagnostic testing, including guidance for a specimen pooling process in order to evaluate performance of the SARS-CoV-2 nucleic acid amplification assay. This study aimed to evaluate the testing of pooled specimens consisting of four nasopharyngeal swab specimens using the Luminex ARIES^® nucleic acid amplification platform. Results indicated that there was a loss of analytic sensitivity with pooled nasopharyngeal swab samples, demonstrating that this approach should be …

Machine Learning Approach To Simulate Soil Co2 Fluxes Under Cropping Systems, Toby A. Adjuik, Sarah C. Davis

Biosystems and Agricultural Engineering Graduate Research

With the growing number of datasets to describe greenhouse gas (GHG) emissions, there is an opportunity to develop novel predictive models that require neither the expense nor time required to make direct field measurements. This study evaluates the potential for machine learning (ML) approaches to predict soil GHG emissions without the biogeochemical expertise that is required to use many current models for simulating soil GHGs. There are ample data from field measurements now publicly available to test new modeling approaches. The objective of this paper was to develop and evaluate machine learning (ML) models using field data (soil temperature, soil …

Conquer And Prevail Issue 95 January 14 2022, Wofford College. Office Of Marketing And Communications

Conquer and Prevail Newsletter

No abstract provided.

Generation And Application Of Inducible Chimeric Rna, Yichen Luo, Liang Du, Zhimeng Yao, Fan Liu, Kai Li, Feifei Li, Jianlin Zhu, Robert P Coppes, Dianzheng Zhang, Yunlong Pan, Shegan Gao, Hao Zhang

PCOM Scholarly Works

Chimeric RNAs (chiRNAs) play many previously unrecognized roles in different diseases including cancer. They can not only be used as biomarkers for diagnosis and prognosis of various diseases but also serve as potential therapeutic targets. In order to better understand the roles of chiRNAs in pathogenesis, we inserted human sequences into mouse genome and established a knockin mouse model of the tamoxifen-inducible expression of ASTN2-PAPPA antisense chimeric RNA (A-PaschiRNA). Mice carrying the A-PaschiRNA knockin gene do not display any apparent abnormalities in growth, fertility, histological, hematopoietic, and biochemical indices. Using this model, we dissected the role of …

Moisture-Tolerant And Operationally Simple Synthesis Of Synthetic Polypeptides And Polypeptoids By Ring-Opening Polymerization Of N-Thiocarboxyanhydrides, David Siefker

LSU Doctoral Dissertations

ABSTRACT

This work aims to develop a new synthetic strategy for synthesizing advanced functional This work aims to develop a new synthetic strategy for synthesizing advanced functional pseudo-peptidic polymers. Pseudo-peptidic polymers mimic poly(glycine) backbone with substituents on either the α-carbon or the nitrogen, appealing properties for various biomedical applications. One of the critical challenges in pseudo-peptidic polymers research is the synthesis of functional pseudo-peptidic polymers under mild conditions. We developed a system based on ring-opening polymerization (ROP) of N-Thiocarboxyanhydrides (NTAs) initiated by primary amines to synthesize polypeptides with a wide range of controlled molecular weights …

Cancer Screening Differences Among Muslims And Non-Muslims: Insights From The Chicago Multiethnic Prevention And Surveillance Study., Amry Majeed, Zeeshan A. Khan, Briseis Aschebrook-Kilfoy, Muhammad G Kibriya, Habibul Ahsan, Aasim I Padela

Student Papers, Posters & Projects

BACKGROUND: While cancer screening disparities along socioeconomic and racial/ethnic lines are well studied, differences based on religious affiliation are under-researched. Though diverse in terms of race/ethnicity, Muslim Americans appear to share values and beliefs that similarly inform their health and healthcare seeking behaviors. Cancer screening disparities among Muslim Americans are also understudied.

METHODS: To examine differences in cancer screening behaviors based on Muslim affiliation, we analyzed data from a longitudinal cohort study examining lifestyle, healthcare access, environmental, and genetic factors on the health of Chicagoans.

RESULTS: Of 7552 participants, 132 (1.7%) were Muslim. Between Muslim and non-Muslims, there were no …

Reprogramming Of Sorghum Proteome In Response To Sugarcane Aphid Infestation, Sajjan Grover, Juan Betancurt Cardona, Prince Zogli, Sophie Alvarez, Michael J. Naldrett, Scott E. Sattler, Joe Louis

Department of Entomology: Faculty Publications

Sugarcane aphid (SCA; Melanaphis sacchari Zehntner) is a key piercing-sucking pest of sorghum (Sorghum bicolor) that cause significant yield losses. While feeding on host plants, complex signaling networks are invoked from recognition of insect attack to induction of plant defenses. Consequently, these signaling networks lead to the production of insecticidal compounds or limited access of nutrients to insects. Previously, several studies were published on the transcriptomics analysis of sorghum in response to SCA infestation, but no information is available on the physiological changes of sorghum at the proteome level. We used the SCA resistant sorghum genotype SC265 for …

Politics Is Making Us Sick: The Negative Impact Of Political Engagement On Public Health During The Trump Administration, Kevin Smith

Department of Political Science: Faculty Publications

Objectives To quantify the effect of politics on the physical, psychological, and social health of American adults during the four-year span of the Trump administration.

Methods A previously validated politics and health scale was used to compare health markers in nationally representative surveys administered to separate samples in March 2017 (N = 800) and October 2020 (N = 700). Participants in the 2020 survey were re-sampled approximately two weeks after the 2020 election and health markers were compared to their preelection baselines.

Results Large numbers of Americans reported politics takes a significant toll on a range of health markers—everything from …

Harnessing Mycobacterium Bovis Bcg Trained Immunity To Control Human And Bovine Babesiosis, Reginaldo G. Bastos, Heba F. Alzan, Vignesh A. Rathinasamy, Brian M. Cooke, Odir A. Dellagostin, Raul G. Barletta, Carlos E. Suarez

School of Veterinary and Biomedical Sciences: Faculty Publications

Babesiosis is a disease caused by tickborne hemoprotozoan apicomplexan parasites of the genus Babesia that negatively impacts public health and food security worldwide. Development of effective and sustainable vaccines against babesiosis is currently hindered in part by the absence of definitive host correlates of protection. Despite that, studies in Babesia microti and Babesia bovis, major causative agents of human and bovine babesiosis, respectively, suggest that early activation of innate immune responses is crucial for vertebrates to survive acute infection. Trained immunity (TI) is defined as the development of memory in vertebrate innate immune cells, allowing more efficient responses to subsequent …