Digital Commons Network^™

Seagrassnet Monitoring In The Great Bay Estuary, Nh/Mefield Season 2020, Kalle Matso, Trevor Mattera, David Burdick, Lara Martin, Amanda Giacchetti, Tom Gregory

PREP Reports & Publications

No abstract provided.

From Consent To Empowerment In Support Of Decision-Making In Embryonic Genetic Design, Pamela Laufer-Ukeles

Chicago-Kent Law Review

No abstract provided.

Understanding The Regulation Of Innate Immune Mechanisms And Its Relevance In Diseases Using Drosophila Melanogaster, Pooja Kadaba Ranganath

Theses and Dissertations

Drosophila melanogaster is an excellent model organism to study conserved innate immune mechanisms. D. melanogaster utilizes both humoral and cellular immune responses to combat fungal, bacterial and parasitic pathogens; The cellular immune response targets parasites and parasitoid wasps are a major parasite of D. melanogaster. Fly larvae are commonly infected by parasitoid wasps and in response, mount a robust cellular immune response against the parasitoid egg. Numerous signaling pathways like JNK and JAK-STAT have been shown to play a role in the immune response against parasitoid wasps and have a conserved role in human immunity. However, the regulation of the …

Territory Holders Are More Aggressive Towards Older, More Dangerous Floaters, Walter H. Piper, Katherine R. Lee, Brian Hoover

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Animals that show aggression often risk injury and incur steep energetic costs. Thus, aggression should occur at such times and towards such opponents as to maximize fitness. We tested hypotheses predicting adaptive territorial aggression in the common loon, a species in which ease of observation of territory owners and floaters (prebreeders) seeking to evict them provide a rare window onto owner-floater competition. As predicted, older, more competitive floaters (4-year-olds and upwards) tended to intrude into territories that had produced chicks the previous year (and, hence, were of high quality). Older floaters also showed predicted increases in aggression and territorial yodeling, …

Preliminary Evidence That Lectins In Infant Soy Formula Apparently Bind Bovine Milk Exosomes And Prevent Their Absorption In Healthy Adults, Ezra Mutai, Alice Kah Hui Ngu, Janos Zempleni

Department of Nutrition and Health Sciences: Faculty Publications

Background: Milk exosomes and their microRNA (miR) cargos are bioavailable. The content of exosomes and miRs is negligible in infant formulas compared to human milk, and dietary depletion of exosomes led to changes in bacterial communities and impaired gut health in juvenile mice. Adverse effects of formula feeding may be compounded by using soy formulas due to exosome binding by abundant lectins in that matrix. The purpose of this study was to assess the bioavailability of milk exosomes and their miR cargos added to soy formula in adults, as well as the potential role of soy lectins in exosome …

Does A Custodial Rights Understanding Of The Gdpr Justify Fraudulent Misrepresentation By Sperm Donors?, Dov Greenbaum

Chicago-Kent Law Review

No abstract provided.

Effects Of Religiosity And Travel Desire On Covid-19 Vaccination Intentions, Muhammet Kesgin, Ali Selcuk Can, Dogan Gursoy, Yuksel Ekinci, Khaled Aldawodi

Articles

Despite the deadly consequences of the COVID-19 pandemic, vaccine hesitation remains a threat to public health and international travel. This study tests the effect of Muslim religiosity on belief-based attitudes (i.e., subjective norms, perceived behavioural control) and travel desire as a proxy for COVID-19 vaccination intentions. The structural model was tested using PLS-SEM with the data collected via a self-administrated survey between April and June 2021 in Saudi Arabia (N=759). Results reveal that travel desire along with belief-based attitudes influence COVID-19 vaccination intentions. Intrinsic religiosity influences individuals’ subjective norms, directly and perceived behavioural control and COVID-19 vaccination intentions indirectly through …

Long-Term Water Balance Evaluation In Glass Ionomer Restorative Materials, Howard Roberts, David Berzins, John Nicholson

Oral Health Practice Faculty Publications

The complex role of water in glass ionomer cement (polyalkenoate) dental restorative materials has been studied, but much of the present understanding concerning water balance within these materials is based on very early studies and short-term experiments. This study evaluated the nature of the water species of six conventional and four resin modified glass ionomer restorative materials over 3 years using thermogravimetric analysis techniques. Materials were prepared, placed in crucibles, and stored in physiologic phosphate buffered saline and evaluated at 24 h, 1 week, and then at 1, 3, 6, 9, 12, 18, 24, 30 and 36 months. All materials …

Surface Acoustic Wave (Saw) Sensors: Physics, Materials, And Applications, Debdyuti Mandal, Sourav Banerjee

Faculty Publications

Surface acoustic waves (SAWs) are the guided waves that propagate along the top surface of a material with wave vectors orthogonal to the normal direction to the surface. Based on these waves, SAW sensors are conceptualized by employing piezoelectric crystals where the guided elastodynamic waves are generated through an electromechanical coupling. Electromechanical coupling in both active and passive modes is achieved by integrating interdigitated electrode transducers (IDT) with the piezoelectric crystals. Innovative meta-designs of the periodic IDTs define the functionality and application of SAW sensors. This review article presents the physics of guided surface acoustic waves and the piezoelectric materials …

A Systematic Approach For Developing Feed-Forward/Back-Propagating Neural Network Models For Predicting Bulk Chemical And Physical Properties Of Transition Metals, Neil Clifton Mitchell

Theses and Dissertations

Bulk materials made from transition elements and their alloys are substances used in many industrial applications and are composed of elements contained in the d- and f-blocks of the periodic table. Many of the useful properties of these materials are related to their unfilled d- and f-orbitals. It is supposed that computational models of orbitals describing two-atom homogeneous clusters of transition elements provide enough information to predict bulk chemical and physical properties of transition materials. This thesis reports the use of a simple (one hidden node) three layer feed-forward/back-propagating artificial neural network and orbital energies obtained from DFT-SCF/MO approximations to …

January 21, 2022 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Strengthening A Linear Reformulation Of The 0-1 Cubic Knapsack Problem Via Variable Reordering, Richard Forrester, Lucas Waddell

Faculty Journal Articles

The 0-1 cubic knapsack problem (CKP), a generalization of the classical 0-1 quadratic knapsack problem, is an extremely challenging NP-hard combinatorial optimization problem. An effective exact solution strategy for the CKP is to reformulate the nonlinear problem into an equivalent linear form that can then be solved using a standard mixed-integer programming solver. We consider a classical linearization method and propose a variant of a more recent technique for linearizing 0-1 cubic programs applied to the CKP. Using a variable reordering strategy, we show how to improve the strength of the linear programming relaxation of our proposed reformulation, which ultimately …

Cryofouling Avoidance In The Antarctic Scallop Adamussium Colbecki, William S. Wong, Lukas Hauer, Paul A. Cziko, Konrad Meister

Faculty, Staff, and Students

The presence of supercooled water in polar regions causes anchor ice to grow on submerged objects, generating costly problems for engineered materials and life-endangering risks for benthic communities. The factors driving underwater ice accretion are poorly understood, and passive prevention mechanisms remain unknown. Here we report that the Antarctic scallop Adamussium colbecki appears to remain ice-free in shallow Antarctic marine environments where underwater ice growth is prevalent. In contrast, scallops colonized by bush sponges in the same microhabitat grow ice and are removed from the population. Characterization of the Antarctic scallop shells revealed a hierarchical micro-ridge structure with sub-micron nano-ridges …

Exploring Substance Use And Frequency In International Students Through The Lens Of Acculturation And Social Cognitive Theory, Queenette Chimeucheya Otamiri

Health and Kinesiology Theses

Design/Objective: The research is a quantitative exploratory cross-sectional survey among international students. The goal of the research was to explore the relationship between acculturation and patterns and prevalence of substance use among the participants.

Background: There is a paucity of data regarding the influence of acculturation on recreational drug consumption and the prevalence of substance use in the United States among international college students. College students are a high-risk population for drug abuse. Substance abuse among youth is a global problem that has detrimental consequences for one’s health, family, community, and educational and professional life (Makanjuola et al., …

An Exploratory Study On The Microbiome Of Northern And Southern Populations Of Ixodes Scapularis Ticks Predicts Changes And Unique Bacterial Interactions, Deepak Kumar, Latoyia P. Downs, Abdulsalam Adegoke, Erika Machtinger, Kelly Oggenfuss, Richard S. Ostfeld, Monica Embers, Shahid Karim

Faculty Publications

The black-legged tick (Ixodes scapularis) is the primary vector of Borrelia burgdorferi, the causative agent of Lyme disease in North America. However, the prevalence of Lyme borreliosis is clustered around the Northern States of the United States of America. This study utilized a metagenomic sequencing approach to compare the microbial communities residing within Ix. scapularis populations from northern and southern geographic locations in the USA. Using a SparCC network construction model, we performed potential interactions between members of the microbial communities from Borrelia burgdorferi–infected tissues of unfed and blood-fed ticks. A significant difference in bacterial composition …

Trait Energy And Fatigue May Be Connected To Gut Bacteria Among Young Physically Active Adults: An Exploratory Study, Ali Boolani, Karyn M. Gallivan, Kristin S. Ondrak, Courtney J. Christopher, Hector F. Castro, Shawn R. Campagna, Christopher M. Taylor, Meng Luo, Scot E. Dowd, Matthew Lee Smith, Lauri O. Byerley

School of Medicine Faculty Publications

Recent scientific evidence suggests that traits energy and fatigue are two unique unipolar moods with distinct mental and physical components. This exploratory study investigated the correlation between mental energy (ME), mental fatigue (MF), physical energy (PE), physical fatigue (PF), and the gut microbiome. The four moods were assessed by survey, and the gut microbiome and metabolome were determined from 16 S rRNA analysis and untargeted metabolomics analysis, respectively. Twenty subjects who were 31 ± 5 y, physically active, and not obese (26.4 ± 4.4 kg/m2) participated. Bacteroidetes (45%), the most prominent phyla, was only negatively correlated with PF. The second …

Nanostring Digital Molecular Profiling Of Protein And Microrna In Rhabdomyosarcoma., Atif Ahmed, Midhat S. Farooqi, Sahibu Sultan M Habeebu, Elizabeth Gonzalez, Terrie Flatt, Ashley L. Wilson, Frederic G. Barr

Manuscripts, Articles, Book Chapters and Other Papers

Purpose: Rhabdomyosarcoma (RMS) exhibits a complex prognostic algorithm based on histologic, biologic and clinical parameters. The embryonal (ERMS) and spindle cell-sclerosing RMS (SRMS) histologic subtypes warrant further studies due to their heterogenous genetic background and variable clinical behavior. NanoString digital profiling methods have been previously highlighted as robust novel methods to detect protein and microRNA expression in several cancers but not in RMS.

Methods/patients: To identify prognostic biomarkers, we categorized 12 ERMS and SRMS tumor cases into adverse (n = 5) or favorable (n = 7) prognosis groups and analyzed their signaling pathways and microRNA profiles. The digital …

Editorial: Ecology, Metabolism And Evolution Of Archaea-Perspectives From Proceedings Of The International Workshop On Geo-Omics Of Archaea, Brian P. Hedlund, Chuanlun Zhang, Fengping Wang, Christian Rinke, William F. Martin

Life Sciences Faculty Research

To facilitate global efforts in addressing fundamental questions related to the biology of archaea, an international consortium of experts organized the International Workshop on Geo-Omics of Archaea (IWGOA), with the overarching themes of Ecology/Biogeochemistry, Metabolism, and Evolution. The IWGOA was held in Shenzhen, China, from October 25th to 27th, 2019. The meeting was attended by more than 200 attendees from China, Japan, USA, Australia, Germany, and France. Some of the most exciting oral and poster presentations made at the IWGOA are celebrated in this Research Topic Figure 1. The 21 manuscripts herein span different aspects of archaeal biology in both …

Common Genetic Variants Contribute To Risk Of Transposition Of The Great Arteries, Doris Škorić-Milosavljević, Rafik Tadros, Fernanda M Bosada, Federico Tessadori, Jan Hendrik Van Weerd, Odilia I Woudstra, Fleur V Y Tjong, Najim Lahrouchi, Fanny Bajolle, Heather J Cordell, A J Agopian, Gillian M Blue, Daniela Q C M Barge-Schaapveld, Marc Gewillig, Christoph Preuss, Elisabeth M Lodder, Phil Barnett, Aho Ilgun, Leander Beekman, Karel Van Duijvenboden, Regina Bokenkamp, Martina Müller-Nurasyid, Hubert W Vliegen, Thelma C Konings, Joost P Van Melle, Arie P J Van Dijk, Roland R J Van Kimmenade, Jolien W Roos-Hesselink, Gertjan T Sieswerda, Folkert Meijboom, Hashim Abdul-Khaliq, Felix Berger, Sven Dittrich, Marc-Phillip Hitz, Julia Moosmann, Frank-Thomas Riede, Stephan Schubert, Pilar Galan, Mark Lathrop, Hans M Munter, Ammar Al-Chalabi, Christopher E Shaw, Pamela J Shaw, Karen E Morrison, Jan H Veldink, Leonard H Van Den Berg, Sylvia Evans, Marcelo A Nobrega, Ivy Aneas, Milena Radivojkov-Blagojević, Thomas Meitinger, Erwin Oechslin, Tapas Mondal, Lynn Bergin, John F Smythe, Luis Altamirano-Diaz, Jane Lougheed, Berto J Bouma, Marie-A Chaix, Jennie Kline, Anne S Bassett, Gregor Andelfinger, Roel L F Van Der Palen, Patrice Bouvagnet, Sally-Ann B Clur, Jeroen Breckpot, Wilhelmina S Kerstjens-Frederikse, David S Winlaw, Ulrike M M Bauer, Seema Mital, Elizabeth Goldmuntz, Bernard Keavney, Damien Bonnet, Barbara J Mulder, Michael W T Tanck, Jeroen Bakkers, Vincent M Christoffels, Cornelis J Boogerd, Alex V Postma, Connie R Bezzina

Faculty, Staff and Student Publications

RATIONALE: Dextro-transposition of the great arteries (D-TGA) is a severe congenital heart defect which affects approximately 1 in 4,000 live births. While there are several reports of D-TGA patients with rare variants in individual genes, the majority of D-TGA cases remain genetically elusive. Familial recurrence patterns and the observation that most cases with D-TGA are sporadic suggest a polygenic inheritance for the disorder, yet this remains unexplored.

OBJECTIVE: We sought to study the role of common single nucleotide polymorphisms (SNPs) in risk for D-TGA.

METHODS AND RESULTS: We conducted a genome-wide association study in an international set of 1,237 patients …

Detection Of Crop Diseases Using Enhanced Variability Imagery Data And Convolutional Neural Networks, Shai Kendler, Ran Aharoni, Sierra N. Young, Hanan Sela, Tamar Kis-Papo, Tzion Fahima, Barak Fishbain

Civil and Environmental Engineering Faculty Publications

The timely detection of crop diseases is critical for securing crop productivity, lowering production costs, and minimizing agrochemical use. This study presents a crop disease identification method that is based on Convolutional Neural Networks (CNN) trained on images taken with consumer-grade cameras. Specifically, this study addresses the early detection of wheat yellow rust, stem rust, powdery mildew, potato late blight, and wild barley net blotch. To facilitate this, pictures were taken in situ without modifying the scene, the background, or controlling the illumination. Each image was then split into several patches, thus retaining the original spatial resolution of the image …

Interplay Between An Atp-Binding Cassette F Protein And The Ribosome From Mycobacterium Tuberculosis, Zhicheng Cui, Xiaojun Li, Joonyoung Shin, Howard Gamper, Ya-Ming Hou, James C Sacchettini, Junjie Zhang

Department of Biochemistry and Molecular Biology Faculty Papers

EttA, energy-dependent translational throttle A, is a ribosomal factor that gates ribosome entry into the translation elongation cycle. A detailed understanding of its mechanism of action is limited due to the lack of high-resolution structures along its ATPase cycle. Here we present the cryo-electron microscopy (cryo-EM) structures of EttA from Mycobacterium tuberculosis (Mtb), referred to as MtbEttA, in complex with the Mtb 70S ribosome initiation complex (70SIC) at the pre-hydrolysis (ADPNP) and transition (ADP-VO4) states, and the crystal structure of MtbEttA alone in the post-hydrolysis (ADP) state. We observe that MtbEttA binds the E-site of the Mtb 70SIC, remodeling the …

Loss Of Irf2bpl Impairs Neuronal Maintenance Through Excess Wnt Signaling, Paul C Marcogliese, Debdeep Dutta, Shrestha Sinha Ray, Nghi D P Dang, Zhongyuan Zuo, Yuchun Wang, Di Lu, Fatima Fazal, Thomas A Ravenscroft, Hyunglok Chung, Oguz Kanca, Jijun Wan, Emilie D Douine, Undiagnosed Diseases Network, Loren D M Pena, Shinya Yamamoto, Stanley F Nelson, Matthew Might, Kathrin C Meyer, Nan Cher Yeo, Hugo J Bellen

Duncan NRI Faculty and Staff Publications

De novo truncations in Interferon Regulatory Factor 2 Binding Protein Like (IRF2BPL) lead to severe childhood-onset neurodegenerative disorders. To determine how loss of IRF2BPL causes neural dysfunction, we examined its function in Drosophila and zebrafish. Overexpression of either IRF2BPL or Pits, the Drosophila ortholog, represses Wnt transcription in flies. In contrast, neuronal depletion of Pits leads to increased wingless (wg) levels in the brain and is associated with axonal loss, whereas inhibition of Wg signaling is neuroprotective. Moreover, increased neuronal expression of wg in flies is sufficient to cause age-dependent axonal loss, similar to reduction …

Democratizing Bioinformatics Through Easily Accessible Software Platforms For Non-Experts In The Field, Konstantinos Krampis

Publications and Research

No abstract provided.

An Estrogen-Sensitive Hypothalamus-Midbrain Neural Circuit Controls Thermogenesis And Physical Activity, Hui Ye, Bing Feng, Chunmei Wang, Kenji Saito, Yongjie Yang, Lucas Ibrahimi, Sarah Schaul, Nirali Patel, Leslie Saenz, Pei Luo, Penghua Lai, Valeria Torres, Maya Kota, Devin Dixit, Xing Cai, Na Qu, Ilirjana Hyseni, Kaifan Yu, Yuwei Jiang, Qingchun Tong, Zheng Sun, Benjamin R Arenkiel, Yanlin He, Pingwen Xu, Yong Xu

Faculty, Staff and Students Publications

Estrogen receptor–α (ERα) expressed by neurons in the ventrolateral subdivision of the ventromedial hypothalamic nucleus (ERαvlVMH) regulates body weight in females, but the downstream neural circuits mediating this biology remain largely unknown. Here we identified a neural circuit mediating the metabolic effects of ERαvlVMH neurons. We found that selective activation of ERαvlVMH neurons stimulated brown adipose tissue (BAT) thermogenesis, physical activity, and core temperature and that ERαvlVMH neurons provide monosynaptic glutamatergic inputs to 5-hydroxytryptamine (5-HT) neurons in the dorsal raphe nucleus (DRN). Notably, the ERαvlVMH → DRN circuit responds to changes in ambient temperature and nutritional states. We further showed …

Early Evidence Of The Sars-Cov-2 B.1.1.529 (Omicron) Variant In Community Wastewater: United States, November–December 2021, Amy Kirby, Rory M. Welsh, Zachary Marsh, Davida S. Smyth, Et Al.

Biology Faculty Publications (Archived)

Notes from the Field: Early Evidence of the SARS-CoV-2 B.1.1.529 (Omicron) Variant in Community Wastewater — United States, November–December 2021

Covers: California, Colorado, New York City, Houston

Grandi Byen-Supporting Child Growth And Development Through Integrated, Responsive Parenting, Nutrition And Hygiene: Study Protocol For A Randomized Controlled Trial, Patricia L Kohl, Emmanuel A Gyimah, Jenna Diaz, F Matthew Kuhlmann, Sherlie Jean-Louis Dulience, Fithi Embaye, Derek S Brown, Shenyang Guo, Joan L Luby, Jennifer L Nicholas, Jay Turner, Melissa Chapnick, Joseline Marhone Pierre, Jacques Boncy, Rony St Fleur, Maureen M Black, Lora L Iannotti

2020-Current year OA Pubs

BACKGROUND: Poor child growth and development outcomes stem from complex relationships encompassing biological, behavioral, social, and environmental conditions. However, there is a dearth of research on integrated approaches targeting these interwoven factors. The Grandi Byen study seeks to fill this research gap through a three-arm longitudinal randomized controlled trial which will evaluate the impact of an integrated nutrition, responsive parenting, and WASH (water, sanitation and hygiene) intervention on holistic child growth and development.

METHODS: We will recruit 600 mother-infant dyads living in Cap-Haitien, Haiti and randomize them equally into one of the following groups: 1) standard well-baby care; 2) nutritional …

Editorial: Adaptation Of Trees To Climate Change: Mechanisms Behind Physiological And Ecological Resilience And Vulnerability, Andrea Ghirardo, James D. Blande, Nadine K. Ruehr, Raffaella Balestrini, Carsten Külheim

Michigan Tech Publications, Part 1

No abstract provided.

Pparα And Pparγ Activation Is Associated With Pleural Mesothelioma Invasion But Therapeutic Inhibition Is Ineffective, M. Lizeth Orozco Morales, Catherine A. Rinaldi, Emma De Jong, Sally M. Lansley, Joel P. A. Gummer, Bence Olasz, Shabarinath Nambiar, Danika E. Hope, Thomas H. Casey, Y. C. Gary Lee, Connull Leslie, Gareth Nealon, David M. Shackleford, Andrew K. Powell, Marina Grimaldi, Patrick Balaguer, Rachael M. Zemek, Anthony Bosco, Matthew J. Piggott, Alice Vrielink, Richard A. Lake, W. Joost Lesterhuis

Research outputs 2022 to 2026

Mesothelioma is a cancer that typically originates in the pleura of the lungs. It rapidly invades the surrounding tissues, causing pain and shortness of breath. We compared cell lines injected either subcutaneously or intrapleurally and found that only the latter resulted in invasive and rapid growth. Pleural tumors displayed a transcriptional signature consistent with increased activity of nuclear receptors PPARα and PPARγ and with an increased abundance of endogenous PPAR-activating ligands. We found that chemical probe GW6471 is a potent, dual PPARα/γ antagonist with anti-invasive and anti-proliferative activity in vitro. However, administration of GW6471 at doses that provided sustained plasma …

Effect Of Seeding Rates On Productivity And Quality Of Alfalfa In Northern Area Of Korea, Jong Geun Kim, C. Liu, S. N. Wei, Y. F. Li, E. C. Jeong, H. J. Kim

IGC Proceedings (1977-2023)

Alfalfa cultivation in South Korea is not common. There are many reasons, but low productivity has been extremely limited. Although alfalfa growth was poor due to boron deficiency in the soil, the problem has recently been solved. Nevertheless, the cultivation of alfalfa is not expanding. About 200,000 tonnes of alfalfa hay are imported every year. Therefore, this study was conducted to find a way to replace imported hay by expanding alfalfa cultivation in Korea. Alfalfa (P5444) was sown in northern part of South Korea (Pyeongchang). Alfalfa was sown in September 2018 with different seeding rates (20, 30 and 40 kg/ha) …

Effect Of Prompt-Delayed Packaging And Ensiling Time On Fermentation And Aerobic Stability Of Soybean Curd Residue, Ajmal Wali, Takeshi Tsuruta, Naoki Nishino

IGC Proceedings (1977-2023)

Wet soybean curd residue (SCR) obtained from two tofu factories (F1 and F2) was anaerobically stored with or without added beet pulp (BP). Sealing was performed on the day of tofu production (prompt sealing [PS]) or 2 days after SCR was piled and unprocessed (delayed sealing [DS]). Predominant lactic acid fermentation was observed regardless of the sealing time and BP addition. Acinetobacter spp. were the most abundant (> 67%) bacteria in pre-ensiled SCR, regardless of the factory and sealing time. In PS silage, the abundances of typical lactic acid-producing bacteria, such as Lactobacillus, Pediococcus, and Streptococcus spp. reached …