Digital Commons Network^™

Maximizing Social Welfare Through The Tailoring Of Patent Duration And Using Algorithms To Calculate Optimal Patent Duration, Alvaro Cure Dominguez

Northwestern Journal of Technology and Intellectual Property

Patents are legal devices granted by the government that confer inventors exclusive rights to their invention for a limited time. In exchange, the U.S. government requires the inventors to publicly disclose their invention to allow individuals to recreate it upon expiration of the exclusivity period. Previously, academics regarded patents as a necessary means to overcome the free-rider dilemma (“FRD”), and they assumed that, without patents, society would be deprived of many potentially valuable innovations. This model has come under criticism. Researchers point to cases where inventors would have innovated regardless of a patent grant. They also highlight instances where patent …

Integration Of Electrical Impedance Spectroscopy For Multichannel Cell Culture Measurement, Conard Chan

Master's Theses

ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY (EIS) has been widely used to study the electrical properties of biological material due to its non-invasive nature and experimental reliability. However, most of the precision impedance analyzers used in EIS only provide single- or two-channel measurements which are inadequate for larger-scale multiplexed measurements, such as those found in modern microfluidic cell culture experiments. The Biomedical Microsystems Laboratory has developed a 16-channel cell culture platform with integrated electrode arrays for monitoring cell growth and electrical properties (i.e., the so-called “electrical phenotype”). In this paper, a system consisting of a 16-channel solid-state analog multiplexer (MUX)paired with a low-cost, …

Assessment Of Two Novel Host-Derived Beauveria Bassiana (Hypocreales: Cordycipitaceae) Isolates Against The Citrus Pest, Diaphorina Citri (Hemiptera: Liviidae), Jonathan Cisneros, Justin Wendel, Stefan Jaronski, Christopher Vitek, Matthew Ciomperlik, Daniel Flores

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

The Asian citrus psyllid (ACP), Diaphorina citri Kuwayama (Hemiptera: Liviidae), vectors ‘Candidatus Liberibacter spp.’, the causative agent of Citrus Greening Disease (CGD) or Huanglongbing (HLB). Managing populations of psyllids in the Lower Rio Grande Valley (LRGV), TX, United States is imperative given a continuous increase in HLB-positive trees. A component of integrated pest management (IPM) program is the use of strains of entomopathogenic fungi for the biological control of D. citri. In an attempt to find endemic strains of entomopathogenic fungi that grow favorably under LRGV environmental conditions and naturally infect D. citri, psyllids were collected from …

Baseline Blood Count Levels Increase Odds Of Cytopenia Among Cml Patients In Kenya: A Case Control Study, Angela Mcligeyo, Jamilla Rajab, Peter Oyiro, Mohammed Ezzi, Yatich Bett, Matilda Ong’Ondi, Andrew Odhiambo, Sitna Mwanzi, Nicholas Othieno-Abinya

Internal Medicine, East Africa

Background: Imatinib is the gold standard for the treatment of all phases of Philadelphia positive Chronic Myeloid Leukemia (CML). During treatment, patients may develop cytopenia. We aimed to study the baseline characteristics and factors associated with cytopenia at a Nairobi Hospital.

Methods: This was a retrospective case-control study of patients aged ≥18 years on follow-up at the Glivec Inter‑ national Patient Access Program (GIPAP) clinic from 2007 to 2015. The cases consisted of CML patients on imatinib who developed cytopenia. The controls were CML patients on imatinib who did not develop cytopenia. Baseline socio – demographic, clinical, hematologic, …

Development Of Zinc Oxide/Hydroxyapatite/Poly(D,L-Lactic Acid) Fibrous Scaffold For Tissue Engineering Applications, Victoria Padilla-Gainza, Heriberto Rodríguez-Tobías, Graciela Morales, Antonio Ledezma-Pérez, Carmen Alvarado-Canché, Raúl Loera-Valencia, Cristóbal Rodríguez, Robert Gilkerson, Carlos Trevino De Leo, Karen Lozano

Mechanical Engineering Faculty Publications

Scaffolds based on polymeric fibers represent an engaging biomedical device due to their particular morphology and similarity with extracellular matrices. The biggest challenge to use fibrous materials in the biomedical field is related to their favorable platform for the adhesion of pathogenic microorganisms. Therefore, their optimum performance not only depends on their bioactive potential but also on their antimicrobial properties. The aim of this work was the design of antimicrobial (zinc oxide, ZnO) and bioactive (hydroxyapatite, Hap) fibrous materials using poly(D, L-lactic acid) (PDLLA) as the polymer fiber substrate. Fiber based composite scaffolds were developed using the Forcespinning® technique. For …

Chronoradiobiology Of Breast Cancer: The Time Is Now To Link Circadian Rhythm And Radiation Biology, Nicolas Nelson, Joseph Lombardo, Lauren Matlack, Alexandria Smith, Kamryn Hines, Wenyin Shi, Nicole L Simone

Department of Radiation Oncology Faculty Papers

Circadian disruption has been linked to cancer development, progression, and radiation response. Clinical evidence to date shows that circadian genetic variation and time of treatment affect radiation response and toxicity for women with breast cancer. At the molecular level, there is interplay between circadian clock regulators such as PER1, which mediates ATM and p53-mediated cell cycle gating and apoptosis. These molecular alterations may govern aggressive cancer phenotypes, outcomes, and radiation response. Exploiting the various circadian clock mechanisms may enhance the therapeutic index of radiation by decreasing toxicity, increasing disease control, and improving outcomes. We will review the body’s natural circadian …

Histone Post-Translational Modification Dysregulation Contributes To Toxicity In Amyotrophic Lateral Sclerosis Proteinopathy Models, Seth A. Bennett

Dissertations, Theses, and Capstone Projects

Amyotrophic Lateral Sclerosis (ALS) is the third most common adult onset neurodegenerative disorder worldwide. It is generally characterized by progressive paralysis starting at the limbs ultimately leading to death caused by respiratory failure. There is no cure and current treatments fail to slow the progression of the disease. As such, new treatment options are desperately needed. Epigenetic targets are an attractive possibility because they are reversible. Epigenetics refers to heritable changes in gene expression unrelated to changes in DNA sequence. Histone modifications, a main epigenetic mechanism, occur in many amino acid residues and include phosphorylation, acetylation, methylation as well as …

Stepping Stones Towards Antarctica: Switch To Southern Spawning Grounds Explains An Abrupt Range Shift In Krill, Angus Atkinson, Simeon L. Hill, Christian S. Reiss, Evgeny A. Pakhomov, Gregory Beaugrand, Geraint A. Tarling, Guang Yang, Deborah K. Steinberg, Katrin Schmidt, Martin Edwards, Emilce Rombolá, Frances A. Perry

School of Geography, Earth and Environmental Sciences

Poleward range shifts are a global-scale response to warming, but these vary greatly among taxa and are hard to predict for individual species, localized regions or over shorter (years to decadal) timescales. Moving poleward might be easier in the Arctic than in the Southern Ocean, where evidence for range shifts is sparse and contradictory. Here, we compiled a database of larval Antarctic krill, Euphausia superba and, together with an adult database, it showed how their range shift is out of step with the pace of warming. During a 70-year period of rapid warming (1920s–1990s), distribution centres of both larvae and …

Dentistry In A Multicultural Society: The Impact Of Animal-Based Products On Person-Centred Care, Kamran Ali, Pooja Gupta, Emma Turay, Lorna Burns, Zoe Brookes, Mahwish Raja

Peninsula Dental School

Cultural competence of healthcare professionals requires a combination of awareness, knowledge and skills to provide healthcare services to culturally and lingually diverse populations. The aim of this paper is to raise awareness regarding animal-based constituents in dental products which may not be acceptable to patients from different cultural, spiritual, or religious backgrounds. Animal-based products are used widely in medicine and dentistry. However, patients and sometimes even dental professionals may not be aware of this. This paper identifies some common products used in clinical dentistry which are derived from animal-based sources and discusses the implications of their use in a multicultural …

Partial Treatment Response To Capmatinib In Met-Amplified Metastatic Intrahepatic Cholangiocarcinoma: Case Report & Review Of Literature, Daniel S Lefler, Marni Brisson Tierno, Babar Bashir

Department of Medical Oncology Faculty Papers

Cholangiocarcinoma is a highly morbid gastrointestinal malignancy for which available therapies are limited. Standard of care includes cytotoxic chemotherapies such as gemcitabine, platinum agents, nab-paclitaxel, and fluoropyrimidine analogues. However, tolerability of these regimens varies, and patients who do not tolerate chemotherapy have limited targeted therapies and immunotherapy options. In cholangiocarcinoma, mesenchymal-epithelial transition factor (MET) amplification may present an additional opportunity for a targeted therapeutic approach, especially considering emerging data in non-small cell lung cancer. In this case, we present a metastatic cholangiocarcinoma patient with high-level MET gene amplification for whom capmatinib, a tyrosine kinase inhibitor with activity against c-MET, …

The Effect Of Alternative Lunch Schedule And Traditional Lunch Schedule On North Carolina School English Ii And Math I End Of Course Test Scores, Kristina Nicole Boone Lowe

Doctoral Dissertations and Projects

This casual comparative design study examined the impact of the type of lunch schedule, traditional or alternative, had on EOC scores for English II and Math I in North Carolina schools. A convenience sample of 132 schools from an archival data set obtained from the North Carolina Department of Public Instruction. Using a casual comparative design, two independent samples t tests were conducted to examine the difference in English II and Math I EOC scores between two groups. The data analysis resulted in a failure to reject Null Hypothesis One and failure to reject Null Hypothesis Two. Recommendations for future …

The African American Nuclear Family: Investigating The Healthy Habits Of Successful Long-Term Marriages In The African American Community, Derrick L. Smith

Doctoral Dissertations and Projects

This phenomenological study sought to understand what contributed to the success of long-term marriages in the African American community. Long-term marriage was defined as those lasting 20 years or more. The family systems theory developed by Dr. Murray Bowen guided this study. The study employed a phenomenological approach to qualitative inquiry. Due to the national health crisis, all interviews were conducted through a Zoom conferencing platform. Nine married couples who have been married for at least 20 years or more participated in the study. The following criteria had to be met to participate in the study: race, length of the …

A Transcendental Phenomenological Study Of Attachment Bonding Experiences Of At-Risk Students Who Graduated High School, Nancy Marie Lawrence

Doctoral Dissertations and Projects

The purpose of this study was to describe the attachment bonding experiences of at-risk students who graduated high school. The theory guiding this study was the Attachment Theory by John Bowlby. This theory explains how attachment bonds help at-risk individuals form relationships that assist in the development of psychological health. Data collection sources were composed of participant surveys, semi-structured participant interviews, and written letters of advice to other high school at-risk students. The practical significance derived from this study demonstrated the need to train education professionals of the necessity of developing secure attachment bonds with students and to reflectively develop …

Using Intentional Relationship Building And Community Presence To Minister To An Addicted Population In Cookeville, Tennessee, James Bailey Simpson

Doctoral Dissertations and Projects

Addiction and substance abuse are banes in American society as they destroy lives, families, hopes and dreams. Individuals with potential for productive lives and societal contributions are reduced to hollow shells and find themselves laser-focused on their next fix. Cookeville, Tennessee, is no different than any other rural American town as addiction and substance abuse are prevalent, especially within the northwestern areas of the city. West View Baptist Church was planted in this area in 1950 and has actively attempted to minister to the community's residents for the last 71 years. Recently, internal issues in the congregation and increasing disconnections …

Engaging Middle School Students Through Music History Mini-Lessons: A Mixed-Methods Study, Jessica Bentley Frerich

Doctoral Dissertations and Projects

Understanding history is a vital part of learning. Nearly every question asked in a music classroom about musical context involves its history, from notation to gestures or technicality to aural listening. History can bring music to life for both the performers and listeners. Despite multiple studies on specific historical music events, music history perspectives have not been addressed in the choral classroom. Moreover, research forums have yet to explore engagement factors of middle school students through a music history curriculum in the choir classrooms. Such research could provide a valid model for educators. This mixed-methods research study seeks to determine …

Examining The Influence Of Religious Attitudes, Acceptance Of Change, And Cultural Mistrust On The Utilization Of Therapy For African American Male College Students Utilizing Therapy, Jessica Miranda Shine

Doctoral Dissertations and Projects

Cultural mistrust and fear of potential racism from people in the medical profession may be contributing to a noted disdain for mental health counseling among African American men. The purpose of this study was designed to gain insight into how attitudes toward religious help-seeking, acceptance of change, cultural mistrust, and mental health stigma impact therapy utilization among African American male college students. The review of literature explored the theoretical frameworks followed by the historical perspective, epigenetics, family structure, masculinity concept and help-seeking behaviors, noting barriers, fear, stigmas, spiritual influence, and economic hardships. Acceptance of change-evolving action is not currently endorsed …

Tennessee State Museum Winter 2022 Newsletter & Calendar Events, Tennessee. State Museum.

Tennessee State Museum

No abstract provided.

Sdsu Beef Day 2022 Complete Proceedings, Department Of Animal Science

SDSU Beef Day 2022 Summary Publication

This is the complete proceedings of the South Dakota State University, Department of Animal Science Beef Day 2022. The proceedings contain research presented on the following topics:
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Climate Change Awareness In The United Arab Emirates, Mariam Matar Abdulla Mohammed Almheiri

Theses

Climate change has focused public attention in the United Arab Emirates (UAE) on the role of society in environmental protection. The objective of this study was to determine the level of public awareness of climate change in the seven emirates of the UAE. The study also aimed to determine the spatial and geographical distribution and gender differences, as well as to investigate the possible influence of human activities on climate change impacts. In a cross-sectional survey, the researcher used a questionnaire to collect data from a sample of 4000 participants to answer the research questions. The drop-off pick-up (DOPU) method …

Protein Prediction For Trait Mapping In Diverse Populations, Ryan Schubert, Elyse Geoffroy, Isabelle Gregga, Ashley J. Mulford, Francois Aguet, Kristin Ardlie, Robert Gerszten, Clary Clish, David Van Den Berg, Kent D. Taylor, Peter Durda, W. Craig Johnson, Elaine Cornell, Xiuqing Guo, Yongmei Liu, Russell Tracy, Matthew Conomos, Tom Blackwell, George Papanicolaou, Tuuli Lappalainen, Anna V. Mikhaylova, Timothy A. Thornton, Michael H. Cho, Christopher R. Gignoux, Leslie Lange, Ethan Lange, Stephen S. Rich

Biology: Faculty Publications and Other Works

Genetically regulated gene expression has helped elucidate the biological mechanisms underlying complex traits. Improved high-throughput technology allows similar interrogation of the genetically regulated proteome for understanding complex trait mechanisms. Here, we used the Trans-omics for Precision Medicine (TOPMed) Multi-omics pilot study, which comprises data from Multi-Ethnic Study of Atherosclerosis (MESA), to optimize genetic predictors of the plasma proteome for genetically regulated proteome-wide association studies (PWAS) in diverse populations. We built predictive models for protein abundances using data collected in TOPMed MESA, for which we have measured 1,305 proteins by a SOMAscan assay. We compared predictive models built via elastic net …

Theoretical Explanations On The Persistence Of Ethno-Medical Pregnancy Nutrition Interventions And Recommendations For Possible Biomedical Interventions, Roselyter Riang’A

Population Health, East Africa

Background: Ethno-medical maternal health care practices during pregnancy are extensive among women especially in Low and Middle Income Countries. Little is known as to why there is an extensive use and reliance on ethno-medical malnutrition remedies over biomedical care, and that they can stand the test of time, even though some are detrimental to human health or based on scientifically incorrect notions.

Methods: From September 2014 through April 2018, a narrative review rather than a systematic review format was conducted in PubMed, Google Scholar, and Web of Science to identify and evaluate all associated literature. This review brings …

Construction And Validation Of Prognostic Nomogram For Metaplastic Breast Cancer, Yongfeng Li, Daobao Chen, Haojun Xuan, Mihnea P Dragomir, George A Calin, Xuli Meng, Meng Chen, Hongchuan Jin

Faculty, Staff and Student Publications

In this study we aimed to develop nomogram models for predicting the overall survival (OS) and cancer-specific survival (CSS) of patients with metaplastic breast cancer (MBC). Data of patients diagnosed with MBC from 1973 to 2015 were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate Cox analyses were performed to identify independent prognostic factors for OS and CSS of MBC patients. The obtained prognostic variables were combined to construct nomogram models for predicting OS and CSS in patients with MBC. Model performance was evaluated using concordance index (C-index) and calibration plots. Data from 1125 patients …

Combined Il-2, Agonistic Cd3 And 4–1bb Stimulation Preserve Clonotype Hierarchy In Propagated Non-Small Cell Lung Cancer Tumor-Infiltrating Lymphocytes, Parin Shah, Marie-Andrée Forget, Meredith L Frank, Peixin Jiang, Donastas Sakellariou-Thompson, Lorenzo Federico, Roohussaba Khairullah, Chantal Alexia Neutzler, Ignacio Wistuba, Chi-Wan B Chow, Yan Long, Junya Fujimoto, Shiaw-Yih Lin, Anirban Maitra, Marcelo V Negrao, Kyle Gregory Mitchell, Annikka Weissferdt, Ara A Vaporciyan, Tina Cascone, Jack A Roth, Jianjun Zhang, Boris Sepesi, Don L Gibbons, John V Heymach, Cara L Haymaker, Daniel J Mcgrail, Alexandre Reuben, Chantale Bernatchez

Faculty, Staff and Student Publications

Background: Adoptive cell transfer (ACT) of tumor-infiltrating lymphocytes (TIL) yielded clinical benefit in patients with checkpoint blockade immunotherapy-refractory non-small cell lung cancer (NSCLC) prompting a renewed interest in TIL-ACT. This preclinical study explores the feasibility of producing a NSCLC TIL product with sufficient numbers and enhanced attributes using an improved culture method.

Methods: TIL from resected NSCLC tumors were initially cultured using (1) the traditional method using interleukin (IL)-2 alone in 24-well plates (TIL 1.0) or (2) IL-2 in combination with agonistic antibodies against CD3 and 4-1BB (Urelumab) in a G-Rex flask (TIL 3.0). TIL subsequently underwent a rapid expansion …

A Mechanistic Modeling Framework Reveals The Key Principles Underlying Tumor Metabolism, Shubham Tripathi, Jun Hyoung Park, Shivanand Pudakalakatti, Pratip K Bhattacharya, Benny Abraham Kaipparettu, Herbert Levine

Faculty, Staff and Student Publications

While aerobic glycolysis, or the Warburg effect, has for a long time been considered a hallmark of tumor metabolism, recent studies have revealed a far more complex picture. Tumor cells exhibit widespread metabolic heterogeneity, not only in their presentation of the Warburg effect but also in the nutrients and the metabolic pathways they are dependent on. Moreover, tumor cells can switch between different metabolic phenotypes in response to environmental cues and therapeutic interventions. A framework to analyze the observed metabolic heterogeneity and plasticity is, however, lacking. Using a mechanistic model that includes the key metabolic pathways active in tumor cells, …

Review Of The Invasive Forage Grass, Guinea Grass (Megathyrsus Maximus): Ecology And Potential Impacts In Arid And Semi-Arid Regions, Pushpa Soti, Vanessa Thomas

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Several introduced African grasses are known to present recurring patterns of invasiveness and cause a severe impact on the diversity and functioning of ecosystems worldwide. Megathyrsus maximus (Guinea grass), a forage grass species native to South Africa, is reported to be highly invasive and pose a serious threat to native biodiversity in the introduced range. Despite the severe ecological threats posed by M. maximus worldwide, there is a dearth of information on the ecological and agroecological impact of M. maximus when growing in unintended areas. In this review, we present general information on M. maximus, its distribution and ecological …

Men At Peace: A Creative Ethnography, Henriette Blecher

Postgraduate

Men at Peace is a creative ethnography aiming to facilitate a functional bridge between polarising gender assumptions around communication and to communicate this bridge using poetry. Using an ethnographic approach underpinned by feminist gender theories, this project is a study of masculinities in contemporary Australian society. Stories of men’s experiences were gathered and then transformed into randomised five-lined cut up poems to reveal and understand social, emotional, spiritual, cultural, relational, and material realities of men. The stories men told during this ethnography supported the heteronormative understanding of masculinities that reinforced the narrative that “real men” should not express a wide …

There Is A Time To Be Creative: The Alignment Between Chronotype And Time Of Day, Jana Kuehnel, Ronald Bledow, Markus Kiefer

Research Collection Lee Kong Chian School Of Business

We examine the influence of chronobiological processes on creativity, specifically the influence of a person’s chronotype. Chronotype refers to the setting of a person’s biological clock that gives rise to a distinctive pattern of sleep habits and preferred diurnal activity. We propose a synchrony effect and predict that people are creative when the external clock is aligned with their internal, biological clock. According to our model, positive mood and creative self-efficacy act as affective and cognitive mechanisms of this synchrony effect. We present three studies that test our theorizing: A quasi-experimental field study with 260 employees, a day-reconstruction study with …

Applying Coleman’S Boat In Management Research: Opportunities And Challenges In Bridging Macro And Micro Theory, Amanda Cowen, Floor Rink, Ilya R. P. Cuypers, Denis Gregoire, Ingo Weller

Research Collection Lee Kong Chian School Of Business

Over the years, ongoing conversations in Academy of Management Journal—and the broader management literature—have emphasized the value of research that bridges the macro and micro domains (Hitt, Beamish, Jackson, & Mathieu, 2007; Molloy, Ployhart, & Wright, 2011; Morgeson & Hofmann, 1999; Paruchuri, Perry-Smith, Chattopadhyay, & Shaw, 2018). Calls for cross-boundary work typically argue that bridging these two domains is required to understand and solve the complex management issues that societies face (George, Howard-Grenville, Joshi, & Tihanyi, 2016; House, Rousseau, & Thomas-Hunt, 1995; Kozlowski & Klein, 2000). Responses to the organizational challenges posed by the COVID-19 pandemic, or to societal problems …

Religious Beliefs Of World Boxing Champions As A Factor Of Influence On Ukrainian Society In The Context Of Social Responsibility, Bogdan Synchak, Petro Livak, Olga Kuvaldina

Occasional Papers on Religion in Eastern Europe

The issue regarding the influence of mass media on the public consciousness is one of the priorities in the times of the digitalization of the information space. Great sports such as professional boxing are world-famous and have a wide resonance in the media. As a result, scientists are paying attention to the study of factors of influence that arise during the information coverage of sporting events. Religious beliefs are a conditional plane of differentiation of different worldview systems, but in the 21st century, they are harmoniously integrated into the colors of different cultures, nationalities, and states. Celebrities’ religious beliefs can …

Brief Of Amici Curiae Christian Medical & Dental Associations And Coptic Medical Association Of North America In Support Of Defendants' Motions To Dismiss, John A. Meiser, Francesca M. Genova, Christopher J. Schweickert

Court Briefs

No. 3:21-cv-06654-VC
Lonny Shavelson v. California Department of Health Care Services

From the Argument

Whether and to what extent doctors should be allowed to participate in intentionally ending the lives of their patients is one of the most important questions in public bioethics. The vast majority of states allow no physician participation at all. California is one of nine states that have passed laws allowing physicians to “assist” a patient’s suicide by making lethal drugs available. But each stops there. No state allows what the plaintiffs in this case now demand: that doctors be allowed to actively euthanize patients by …