Digital Commons Network^™

Intramolecular Friedel-Crafts Addition Of Indoles To Tertiary Allylic Alcohols, Bryan H. Wakefield, Romie Barnes, Traeannah Brown, Ashley M. Jones, Victoria A. Knotts, Christina Martinetti

Journal of the South Carolina Academy of Science

An intermolecular Friedel-Crafts alkylation of indole and tertiary allylic alcohols has been developed. The allylic alcohols were synthesized using a two-step procedure, then exposure of these alcohols to diphenyl phosphate facilitated the desired annulation reaction. This reaction tolerated a variety of indole substitutions to yield 1H,2H,3H,4H-pyrido[1,2-a]indoles.

Systems And Processes For Early Detection Of Biological Ammonia Oxidation In Water Using Fluorometry, Julian Fairey, Thien Duc Do, Ashley Pifer, David G. Wahman

Patents Granted

This invention relates generally to a system and process for early detection of biological ammonia oxidation in water utilizing a fluorescence-based sensor and process. Various embodiments are configured to read increases in a fluorescence excitation-emission wavelength pair that is responsive to a period of time (days to weeks or even longer) prior to the onset of biological ammonia oxidation, which is considered to be a nitrification event. Fluorescence excitation/emission pairs that have proven to be reliable include a fluorescence excitation wavelength of about 230 nm and an emission wavelength of about 345 nm and an excitation wavelength of 325 and …

Development Of A Multivariate Model With Desirability-Based Optimization For Determination Of Atenolol And Hydrochlorothiazide By Eco-Friendly Hplc Method With Fluorescence Detection, Ekram Hany Mohamed, Ahmed Hemdan,, Naser F. Al-Tannak,

Pharmacy

Determination of a widely used antihypertensive combination of atenolol and hydrochlorothiazide was achieved by rapid and eco-friendly high-performance liquid chromatography method combined with fluorescence detection. The response surface methodology is conducive to the complete separation of the two drugs in a shorter analysis time. The separation of the mixture was achieved using an Inertsil C18 analytical column (150 × 4.6 mm, 5 µ). The mobile phase used was ethanol: potassium dihydrogen phosphate at pH 3 (65:35 v/v) and the flow rate was 0.7 mL/min. The fluorescence detector operated at excitation and emission wavelengths of 230 and 310 nm (atenolol) and …

Scientists Aren't Hostile Alien Priests: A Review Of Redeeming Expertise, Jeff Ploegstra

Faculty Work Comprehensive List

"We all rely on others to draw valid conclusions about the world, both scientifically and theologically."

Posting about the book Redeeming Expertise from In All Things - an online journal for critical reflection on faith, culture, art, and every ordinary-yet-graced square inch of God’s creation.

https://inallthings.org/scientists-arent-hostile-alien-priests-a-review-of-redeeming-expertise/

A Decade After Ariad: What Is The Written Description Standard For Emerging Bio-Pharma Patents?, Pu-Cheng (Leo) Huang

Washington Journal of Law, Technology & Arts

The Federal Circuit’s en banc decision in Ariad Pharms., Inc. v. Eli Lilly & Co. diverged from its previous interpretation of the “written description” requirement under 35 U.S.C. § 112. The new requirement mandates inventors to prove that they “actually invented the invention claimed.” The court observed that this new requirement is particularly onerous for biotechnological and chemical genus claims where few species have been reduced to practice. The new requirement asks inventors to disclose detailed descriptions for more than one species in the specification to support their genus claims. The heightened standard has massively affected front-end technology research. However, …

Field Pea Diversity And Its Contribution To Farmers' Livelihoods In Northern Ethiopia, Yirga Gufi, Alemtsehay Tsegay, Morgan Ruelle, Kassa Teka, Sarah Tewolde-Berhan, Alison Power

Sustainability and Social Justice

Field pea is grown by smallholder farmers in Ethiopia as a source of food, fodder, income, and soil fertility. This study explores intraspecific diversity of field pea and its contribution to farmers' livelihoods in two agroecological zones of South Tigray and South Wollo, northeastern Ethiopia. Interviews were conducted with 168 farming households. The number of varieties and the Shannon Diversity Index (SDI) were higher in South Tigray (seven varieties, 0.35 SDI) than South Wollo (two varieties, 0.025 SDI). Farmers in South Tigray plant field pea during two growing seasons, allowing for integration of multiple varieties into their farming systems. The …

Cobalt Ferrite Nano-Composites For The Oxidation Of Phenols In Oil Refinery Wastewater, Amira Mohamed

Theses and Dissertations

Phenolic compounds have the tendency to persist in the environment over a long period making them a main source of concern because of their toxic characteristics towards humans and animals (Bruce et al., 1987). Therefore, existence of phenolic compounds in aquatic environment is unfavourable and as a result, many treatment techniques have been implemented to treat the wastewater produced from petroleum refineries. Petroleum refineries are among the top industries that produces significant quantities of high phenol concentration wastewater. Photo-catalysis is a promising and effective method to treat phenol present in oil refineries effluent. In this study, the photo-catalyst used is …

Clinical Validation Of A Spectroscopic Liquid Biopsy For Earlier Detection Of Brain Cancer., James M. Cameron, Paul M. Brennan, Georgios Antoniou, Holly J. Butler, Loren Christie, Justin J A Conn, Tom Curran, Ewan Gray, Mark G. Hegarty, Michael D. Jenkinson, Daniel Orringer, David S. Palmer, Alexandra Sala, Benjamin R. Smith, Matthew J. Baker

Manuscripts, Articles, Book Chapters and Other Papers

Background: Diagnostic delays impact the quality of life and survival of patients with brain tumors. Earlier and expeditious diagnoses in these patients are crucial to reduce the morbidities and mortalities associated with brain tumors. A simple, rapid blood test that can be administered easily in a primary care setting to efficiently identify symptomatic patients who are most likely to have a brain tumor would enable quicker referral to brain imaging for those who need it most.

Methods: Blood serum samples from 603 patients were prospectively collected and analyzed. Patients either had non-specific symptoms that could be indicative of a brain …

Academic Senate - Agenda, 2/22/2022, Academic Senate

Academic Senate Agendas

No abstract provided.

Costly Gadgets: Barriers To Market Entry And Price Competition For Generic Drug-Device Combinations In The United States, Michael S. Sinha

Minnesota Journal of Law, Science & Technology

No abstract provided.

Forecasting Neuromuscular Recovery After Anterior Cruciate Ligament Injury: Athlete Recovery Profiles With Generalized Additive Modeling, Matthew J. Jordan, Nathaniel Morris, Jeremiah Barnert, Drew Lawson, Isabel Aldrich Witt, Walter H Herzog

Research outputs 2022 to 2026

A retrospective analysis of longitudinally collected athlete monitoring data wasconducted to generate a model of neuromuscular recovery after anterior cruciateligament (ACL) injury and reconstruction (ACLR). Neuromuscular testing data in-cluding countermovement jump (CMJ) force‐time asymmetries and knee extensorstrength (maximum voluntary contractionext) asymmetries (between‐limb asymmetryindex—AI) were obtained from athletes with ACLR using semitendinosus (ST) au-tograft (n= 29; AI measurements: n= 494), bone patellar tendon bone autograft(n= 5; AI measurements:n= 88) and noninjured controls (n= 178; AI measurements:n= 3188). Explosive strength measured as the rate of torque development was alsocalculated. CMJ force‐time asymmetries were measured over discrete movementphases (eccentric deceleration phase, concentric phase). …

Facial Recognition Technology And Privacy: Race And Gender - How To Ensure The Right To Privacy Is Protected, Lindsey Jacques

San Diego International Law Journal

This Article specifically focuses on the use of FRT by the five permanent members of the United Nations (“UN”) Security Council which are China, France, the Russian Federation, the United Kingdom, and the United States (the five nations). As permanent members of the Security Council, these five nations are tasked with maintaining international security under the UN Charter.

National leaders in these countries are forced to face the question of whether the national security mitigating benefits of FRT outweigh the privacy and equity concerns the technology imposes for populations often considered the most vulnerable. This Article proposes solutions to this …

Investigation Of A Cluster Of Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2) Infections In A Hospital Administration Building, Lucas D. Jones, Ernest R. Chan, Sarah N. Redmond, Jeffrey D. Kovach, Marlin Linger, Peter A. Zimmerman, Curtis J. Donskey

Faculty Scholarship

Objective: To investigate a cluster of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in employees working on 1 floor of a hospital administration building. Methods: Contact tracing was performed to identify potential exposures and all employees were tested for SARS-CoV-2. Whole-genome sequencing was performed to determine the relatedness of SARS-CoV-2 samples from infected personnel and from control cases in the health-care system with coronavirus disease 2019 (COVID-19) during the same period. Carbon dioxide levels were measured during a workday to assess adequacy of ventilation; readings >800 parts per million (ppm) were considered an indication of suboptimal ventilation. To assess …

The Current State Of Gene Doping And The Future Of Gene Therapy Regulations, Sean Costa

San Diego International Law Journal

Genome editing, also referred to as “gene editing” or “gene therapy,” is no longer a theoretical eventuality of scientific progression; it is a reality of modern life. One of the numerous groups affected by this technology is athletes as “gene doping” becomes a more viable option to improve athletic performance each year. Some international agencies have begun to address the issues presented by gene doping, but there is no comprehensive international framework or regulations on the proper standards of use or punishment for those who abuse this new technology. International agencies must work together to establish regulations for human genome …

Factors Contributing To Bee Decline, Ann Mull, Jaydee Gunnell, Sheriden M. Hansen, Ricardo Ramirez, Andree' Walker Bravo, Cody Zesiger, Lori R. Spears

All Current Publications

Bees provide an important ecosystem service by contributing to the pollination of crop and wild plant species. Many factors have been attributed to bee declines, including habitat loss, improper apiary management, pesticide usage, climate change, pests and pathogens, competition among native and introduced bee species, poor nutrition, and other factors (Koh et al., 2016; Goulson et al., 2015; Graves et al., 2020; Soroye et al., 2020). Acting together, these factors intensify the pressure for survival beyond the adaptability of many species. This fact sheet reviews the factors contributing to decline in bee populations and what can be done to protect …

Deeplasmid: Deep Learning Accurately Separates Plasmids From Bacterial Chromosomes, William B. Andreopoulos, Alexander M. Geller, Miriam Lucke, Jan Balewski, Alicia Clum, Natalia N. Ivanova, Asaf Levy

Faculty Research, Scholarly, and Creative Activity

Plasmids are mobile genetic elements that play a key role in microbial ecology and evolution by mediating horizontal transfer of important genes, such as antimicrobial resistance genes. Many microbial genomes have been sequenced by short read sequencers and have resulted in a mix of contigs that derive from plasmids or chromosomes. New tools that accurately identify plasmids are needed to elucidate new plasmid-borne genes of high biological importance. We have developed Deeplasmid, a deep learning tool for distinguishing plasmids from bacterial chromosomes based on the DNA sequence and its encoded biological data. It requires as input only assembled sequences generated …

Disentangling The Last 1,000 Years Of Human–Environment Interactions Along The Eastern Side Of The Southern Andes (34–52°S Lat.), William Nanavati, Cathy Whitlock, Maria Eugenia De Porras, Adolfo Gil, Diego Navarro, Gustavo Neme

Geography Faculty Publications and Presentations

Researchers have long debated the degree to which Native American land use altered landscapes in the Americas prior to European colonization. Human–environment interactions in southern South America are inferred from new pollen and charcoal data from Laguna El Sosneado and their comparison with high-resolution paleoenvironmental records and archaeological/ethnohistorical information at other sites along the eastern Andes of southern Argentina and Chile (34–52°S). The records indicate that humans, by altering ignition frequency and the availability of fuels, variously muted or amplified the effects of climate on fire regimes. For example, fire activity at the northern and southern sites was low at …

A Study On The Use Of Academic Social Networking Sites (Asnss) By Professional Librarians In Public Universities In Akwa Ibom State, Nigeria, Nse E. Akwang Phd, Cln

Library Philosophy and Practice (e-journal)

This study takes a holistic look at the usefulness of academic social networking sites as the basis of which significant links could be established globally. The use of social media and networking sites is increasingly facilitating communication among people in all walks of life. Professional librarians normally use the sites to connect with each other faster and easier for research purposes, professional development, personal development, as well as entertainment or any other purpose. The popular academic networking sites include LinkedIn, ResearchGate, Quora, Google Scholar, ResearchID, Mendeley, and so on. This study examines the use of academic social networking sites by …

A Tale Of Two-Hybrids: Investigating The Interactomes Of Cullin-Associated Proteins, Elyse Reitter

Dissertations and Theses

Cul3 is the major component of an E3 ligase in human cells. Cul3 was initially identified in the Singer lab as a protein that binds and degrades cyclin E, and subsequent studies have shown it to be part of a complex that is involved in a multitude of biological functions. The nature of this complex, its constituents, its regulation, and its dynamics is just beginning to be understood. The research presented here utilizes a series of two hybrid screens to identify families of interactomes with Cul3 at the center. This information will complement other work in the lab in which …

'Analogy-Based Comprehensive Diabetes Education' (Abcde) Improves Glycemic Control Of Diabetic Patients In An Underserved Population: Results Of A Retrospective Chart Analysis, Rajagopal V Sekhar

Faculty, Staff and Students Publications

Diabetes is the leading global cause for blindness, kidney failure and amputations. Preventing these complications requires optimal glycemic control, and it is imperative that diabetic patients understand the fundamental concepts of diabetes care. Although patients attend formal diabetes education classes, many do not comprehend basic concepts of diabetes, and are often noncompliant with diet, exercise and medications. A novel approach termed 'analogy-based comprehensive diabetes education' (ABCDE) was developed to educate HIV-patients with diabetes about basic concepts of diabetes care. The object of this manuscript is to report the results of a retrospective chart review on the impact of ABCDE on …

Livestock Farmers And Researchers Perceptions About Ecosystem Services Provided By Rio De La Plata Grasslands, Daniela Schossler, Carlos Nabinger, Pablo Boggiano, Diana L. Restrepo-Osorio, Claudio Ribeiro

IGC Proceedings (1977-2023)

The perception and valuation that livestock farmers have about ecosystem services provided by natural pastures is of fundamental importance to their management decisions and the conservation of this resource. This work aims to reveal results of a project carried out in Brazil, Paraguay, Argentina and Uruguay using the TESSA (Toolkit for Ecosystem Service Site-based Assessment) methodology to compare the perceptions of different ecosystem services among livestock farmers and researchers. The methodology was participatory workshops, two by country, one with livestock farmers participating in the Grassland Alliance (at least 50% of natural grassland in the livestock production system) and another with …

Factors Influencing Adoption Of Rangeland Rehabilitation Technologies By Agro-Pastoralists In The Arabian Peninsula: Evidence From Analysis In Saudi Arabia And Qatar, Boubaker Dhehibi, Arash Nejatian, Abdul Aziz Niane, Azaiez Ouled Belgacem

IGC Proceedings (1977-2023)

Rangelands are the main land use in the Arabian Peninsula and cover about 50% of total area. They are under continuous heavy grazing pressure due to underlying social and economic causes as well as institutional effects. ICARDA in collaboration with the National Agricultural Research Systems (NARS) has developed and introduced different rehabilitation techniques including resting, planting native range species and water harvesting in different countries of the AP such as Kuwait, Qatar, Saudi Arabia (KSA) and Yemen. However, the adoption of these techniques by end users was not evaluated. In this context, a research has been conducted in Saudi Arabia …

Effectively Reaching The Equine Community In Kentucky, S. L. Musen, Krista L. Lea, S. Ray Smith, R. J. Coleman

IGC Proceedings (1977-2023)

Since 2009, Extension Specialists and County Extension Agents from the University of Kentucky in the Southeast United States have conducted an annual educational event; the Kentucky Equine Farm and Facilities Expo field-day. These annual field-days have provided practical, hands-on demonstrations and seminars for 135-250 members of the equine community per event. Participants have been a mix of horse owners in relation to farm size, number of horses and business vs. recreation. Many participants have not been previous consumers of Extension educational programming. One of the major draws of the Farm and Facility Expo field days has been the host sites, …

The Relationship Between Adverse Childhood Experience, Guilt Proneness, And Shame-Proneness: An Exploratory Investigation, Martha G. Weaver, Jeremiah Sullins

Modern Psychological Studies

The research on adverse childhood experiences (ACEs) in relation to shame and guilt proneness in adults is limited. Studies have shown that children and adults can be affected by ACEs. More specifically, ACEs are associated with negative health and wellness. This study examines a unique relationship between ACEs and guilt and shame proneness. Participants in this study were comprised of a convenience sample of 137 adults. Two primary assessment instruments were used: Adverse Childhood Experience questionnaire and the Test of Self-Conscious Affect-3 (TOSCA). The surveys were distributed through social media, email, and classrooms . Results revealed a statistically significant positive …

Conference Program, 2022, Marquette University

Interdisciplinary Conference on Disabilities at the Intersection

This is the conference program. There are links within the program for online participants.

Maternal Mortality In The United States: Focusing On Societal Impacts And Potential Solutions [Poster], Grace Petrzelka

Research in the Capitol

This research project explores the available literature on maternal mortality in the United States, and examines social, environmental, and cultural factors for their impact. With a public health focus, included are discussions on forming safer maternal health practices in our country, comparison of statistics on maternal and infant deaths, and using the available data to create potentially life-saving solutions. Specific topics include race, biology, health policy and legislation, insurance coverage, infant mortality, and family planning. This research project covers a span of academic disciplines, and was created to bring these areas together to promote awareness to a sobering, but meaningful …

Anthropogenic Impacts On The Glowworm Cave, Waitomo, New Zealand: A Microclimate Management Approach, Chris Hendy, David J. Merritt, Shannon Corkill

International Journal of Speleology

Waitomo Glowworm Cave is a highly visited cave where the highlight is viewing the bioluminescence display of a large colony of glowworms. The visitation levels result in the build-up of anthropogenic CO₂, to the extent that it could cause corrosion of speleothems. The cave experiences chimney-effect ventilation with air flowing either upward or downward through the main cave chambers depending on air density differences between the cave and the outside environment. Lack of airflow leads to CO₂ build-up; however, unrestricted airflow can draw in cool, dry air which is harmful to the glowworms. Consequently, airflow is managed …

Study Of Pore Length And Chemical Composition Of Charcoal That Results From The Pyrolysis Of Coconut Shell In Bolaang Mongondow, Sulawesi, Indonesia, Meytij Jeanne Rampe, Ignatius Rachmat S. Santoso, Henny Lieke Rampe, Vistarani Arini Tiwow, Tresia Eti Ayuningsi Rorano

Karbala International Journal of Modern Science

Charcoal of coconut shell is produced by pyrolysis at 300^oC and chemically activated using HCl. Both pyrolysis charcoal and chemical activation were measured and analyzed by Fourier Transform Infrared (FTIR), Scanning Electron Microscopy (SEM), and Energy Dispersive Spectroscopy (EDS). The functional groups found O-H, aliphatic C-H, aromatic C=C, C-O, and aromatic C-H. The distribution of pyrolysis charcoal pore length and chemical activation increased from 362 nm-1.02 µm to 1.10 µm-1.52 µm. The composition of carbon elements in the mass % of pyrolysis charcoal and chemical activation increased from 86.11% to 88.93%.

In-Vitro Evaluation Of High Dosage Of Curcumin Encapsulation In Palm-Oil-In-Water, Nanoemulsion Stabilized With A Sonochemical Approach, Uday Dasharath Bagale Phd, Aram Tsaturov, Irina Potoroko, Shital Potdar, Shirish Sonawane Phd

Karbala International Journal of Modern Science

Curcumin is unstable under different environmental conditions. To increase the bioavailability and stability of curcumin, it is proposed in the present study to encapsulate it in palm oil-in-water nanoemulsions using ultrasound. The present work deals with maximum curcumin encapsulation into oil forms stable nanoemulsion using a food-grade surfactant and examines its antioxidant assay and in-vitro study. The synthesized curcumin nanoemulsion (CuNE) shows particle size in the range of 14.7 ± 3 nm, 95 ± 0.5% encapsulation efficiency, and provides stability against different environmental parameters. Furthermore, in-vitro analysis of high dosage CuNE shows more than 80-90% retention during simulated gastric and …

Application Of The Tessa Methodology In A Pilot Protocol For Participatory Evaluation Of Ecosystem Services And Agents Of Change In The Pampa Grasslands. Method Description And Lessons Learned, Daniela Schossler, Carlos Nabinger, Pablo Boggiano, Diana L. Restrepo-Osorio, Claudio Ribeiro

IGC Proceedings (1977-2023)

The Toolkit for Site-Based Assessment (Landscape) of Ecosystem Services (TESSA) is intended to be an accessible guide for low-cost methods to assess the benefits that people receive from nature at particular sites in order to generate information that can be used to influence decision-making (Pehl et al 2015). However, TESSA does not have defined protocols for grasslands ecosystems. This article focuses on the description and discussion of the lessons learned in the participatory workshops that include engaging with policy and decision-making actors. The work consisted of identifying 1) the area occupied by each coverage or use, 2) the threats and …