Digital Commons Network^™

Characterization Of Patient-Derived Bone Marrow Human Mesenchymal Stem Cells As Oncolytic Virus Carriers For The Treatment Of Glioblastoma, Yuzaburo Shimizu, Joy Gumin, Feng Gao, Anwar Hossain, Elizabeth J Shpall, Akihide Kondo, Brittany C Parker Kerrigan, Jing Yang, Daniel Ledbetter, Juan Fueyo, Candelaria Gomez-Manzano, Frederick F Lang

Faculty, Staff and Student Publications

Objective: Delta-24-RGD is an oncolytic adenovirus that is capable of replicating in and killing human glioma cells. Although intratumoral delivery of Delta-24-RGD can be effective, systemic delivery would improve its clinical application. Bone marrow-derived human mesenchymal stem cells (BM-hMSCs) obtained from healthy donors have been investigated as virus carriers. However, it is unclear whether BM-hMSCs can be derived from glioma patients previously treated with marrow-toxic chemotherapy or whether such BM-hMSCs can deliver oncolytic viruses effectively. Herein, the authors undertook a prospective clinical trial to determine the feasibility of obtaining BM-hMSCs from patients with recurrent malignant glioma who were previously exposed …

Local Treatment Of A Pediatric Osteosarcoma Model With A 4-1bbl Armed Oncolytic Adenovirus Results In An Antitumor Effect And Leads To Immune Memory, Naiara Martinez-Velez, Virginia Laspidea, Marta Zalacain, Sara Labiano, Marc García-Moure, Montse Puigdelloses, Lucía Marrodan, Marisol Gonzalez-Huarriz, Guillermo Herrador, Daniel De La Nava, Iker Ausejo-Mauleon, Juan Fueyo, Candelaria Gomez-Manzano, Ana Patiño-García, Marta M Alonso

Faculty, Staff and Student Publications

Osteosarcoma is an aggressive bone tumor occurring primarily in pediatric patients. Despite years of intensive research, the outcomes of patients with metastatic disease or those who do not respond to therapy have remained poor and have not changed in the last 30 years. Oncolytic virotherapy is becoming a reality to treat local and metastatic tumors while maintaining a favorable safety profile. Delta-24-ACT is a replicative oncolytic adenovirus engineered to selectively target cancer cells and to potentiate immune responses through expression of the immune costimulatory ligand 4-1BB. This work aimed to assess the antisarcoma effect of Delta-24-ACT. MTS and replication assays …

Another Second Chance: Rehabilitation Of Marital Rape Offender For The Victim’S Recovery, Iva Kasuma, Farisa Azhara, Afida Ilfa, Shofiyah Adila Farhana

The Indonesian Journal of Socio-Legal Studies

Not all victims of marital rape want a divorce, generally victims long to maintain their marriage and for the perpetrators to correct their own behaviors. Victims are also bound to the strong culture that condones sexual relations without consent as long as it is carried out within the framework of a legal marriage. This study aims to demonstrate the importance of rehabilitation for offenders of marital rape by examining various laws and regulations in Indonesia and the obstacles to their implementation. Methodologically, data were obtained from doctrinal studies of Indonesian law and court decisions related to marital rape and empirical …

Forest Structure And Seasonally Inundated Grassland Shape Tropical Mammal Communities Under Moderate Disturbance, Juliana Masseloux, Quy Tan Le, Jessica Burr, Brian D. Gerber

Natural Resources Science Faculty Publications

Tropical biodiversity is threatened globally by anthropogenic disturbances, particularly forest degradation and overhunting. Where large mammals have been extirpated, smaller bodied “mesomammals” may play an important ecological role (e.g., as seed dispersers). However, these species are disproportionally affected by overhunting for wildlife trade markets and are routinely understudied as they tend to be rare, cryptic, and nocturnal. Few studies have examined spatiotemporal responses to anthropogenic disturbance by mesomammals at the community level, which may identify imbalances within an ecosystem that could threaten species persistence. We deployed camera traps throughout Cat Tien National Park (i.e., Nam Cat Tien area), southern Vietnam, …

Commissioning A Secondary Dose Calculation Software For A 0.35 T Mr-Linac, Alex T Price, Nels C Knutson, Taeho Kim, Olga L Green

Open Access Publications

Secondary external dose calculations for a 0.35 T magnetic resonance image-guided radiation therapy (MRgRT) are needed within the radiation oncology community to follow safety standards set forth within the field. We evaluate the commercially available software, RadCalc, in its ability to accurately perform monitor unit dose calculations within a magnetic field. We also evaluate the potential effects of a 0.35 T magnetic field upon point dose calculations. Monitor unit calculations were evaluated with (wMag) and without (noMag) a magnetic field considerations in RadCalc for the ViewRay MRIdian. The magnetic field is indirectly accounted for by using asymmetric profiles for calculation. …

Partial Ablation Of Postsynaptic Dopamine D2 Receptors In The Central Nucleus Of The Amygdala Increases Risk Avoidance In Exploratory Tasks, Eric Casey, María Elena Avale, Alexxai Kravitz, Marcelo Rubinstein

Open Access Publications

The central nucleus of the amygdala (CeA) is involved in the expression of fear and has been implicated in several anxiety disorders. This structure is densely innervated by DAergic projections that impinge on amygdalar neurons expressing various dopamine (DA) receptor subtypes, including D2 receptors (D2Rs). Although various pharmacological approaches have assessed the role of D2Rs in the CeA, the actual participation of postsynaptic D2Rs in the CeA to defensive behaviors remains unclear. Here, we investigated the distribution of D2Rs in the CeA and their role in modifying neuronal activity and fear related behaviors in mice. First, using the mouse reporter …

Translational Randomized Phase Ii Trial Of Cabozantinib In Combination With Nivolumab In Advanced, Recurrent, Or Metastatic Endometrial Cancer, Stephanie Lheureux, Carolyn Mccourt, Et Al

Open Access Publications

BACKGROUND: Combining immunotherapy and antiangiogenic agents is a promising treatment strategy in endometrial cancer. To date, no biomarkers for response have been identified and data on post-immunotherapy progression are lacking. We explored the combination of a checkpoint inhibitor (nivolumab) and an antiangiogenic agent (cabozantinib) in immunotherapy-naïve endometrial cancer and in patients whose disease progressed on previous immunotherapy with baseline biopsy for immune profiling.

PATIENTS AND METHODS: In this phase II trial (ClinicalTrials.gov NCT03367741, registered December 11, 2017), women with recurrent endometrial cancer were randomized 2:1 to nivolumab with cabozantinib (Arm A) or nivolumab alone (Arm B). The primary endpoint was …

Social Isolation And Incident Heart Failure Hospitalization In Older Women: Women's Health Initiative Study Findings, Crystal W Cené, Xiaoyan Iris Leng, Khushnood Faraz, Matthew Allison, Khadijah Breathett, Chloe Bird, Mace Coday, Giselle Corbie-Smith, Randi Foraker, Nkechinyere N Ijioma, Milagros C Rosal, Shawnita Sealy-Jefferson, Tetyana P Shippee, Candyce H Kroenke

Open Access Publications

Background The association of social isolation or lack of social network ties in older adults is unknown. This knowledge gap is important since the risk of heart failure (HF) and social isolation increase with age. The study examines whether social isolation is associated with incident HF in older women, and examines depressive symptoms as a potential mediator and age and race and ethnicity as effect modifiers. Methods and Results This study included 44 174 postmenopausal women of diverse race and ethnicity from the WHI (Women's Health Initiative) study who underwent annual assessment for HF adjudication from baseline enrollment (1993-1998) through …

Transcriptomic Profile Investigations Highlight A Putative Role For Nudt16 In Sepsis, Susie Shih Yin Huang, Darawan Rinchai, Mohammed Toufiq, Basirudeen Syed Ahamed Kabeer, Jessica Roelands, Wouter Hendrickx, Sabri Boughorbel, Davide Bedognetti, Nicholas Van Panhuys, Damien Chaussabel, Mathieu Garand

Open Access Publications

Sepsis is an aberrant systemic inflammatory response mediated by the acute activation of the innate immune system. Neutrophils are important contributors to the innate immune response that controls the infection, but harbour the risk of collateral tissue damage such as thrombosis and organ dysfunction. A better understanding of the modulations of cellular processes in neutrophils and other blood cells during sepsis is needed and can be initiated via transcriptomic profile investigations. To that point, the growing repertoire of publicly accessible transcriptomic datasets serves as a valuable resource for discovering and/or assessing the robustness of biomarkers. We employed systematic literature mining, …

Fire Effects In Montane Meadows, Rosie Deak

Master's Theses

The impact of forest fires on downstream meadow communities across California is of great ecological interest, as meadows are an important source of biodiversity in this region. Over a century of fire suppression has led to increased forest stand densities, which in turn has resulted in less water availability due to increased transpiration of densely growing trees. This potentially has left less available water for downstream plant communities in meadows. If true, then high mortality wildfires in surrounding forest are predicted to lead to an increase in available downstream moisture where obligate and facultative-wetland taxa increase and dry-adapted upland taxa …

Determinant Of Repeat Revascularization Within 5 Years Of Percutaneous Coronary Lntervention At A Tertiary Care Hospital, Karachi: A Matched Case-Control Study, Komal Valliani, Azmina Artani, Iqbal Azam, Javed Tai, M. Masood Kadir

Community Health Sciences

Objective: To determine factors associated with repeat revascularization among adults aged 25 years and above within 5 years of first Percutaneous Coronary Intervention (PCI) at a tertiary care hospital.
Methods: A matched case-control study was conducted through a hospital records review. A total of 90 cases with repeat revascularization and 180 controls without repeat revascularization were included. Data was analyzed using Multiple Conditional Logistic Regression.
Results: The mean age was similar in cases and controls (60.05 ± 10.01 vs 62.20 ± 10.43 years) and sex (male: 77.8% vs. 76.1%). History of being an ever-smoker (40% vs. 25%), overweight (36.3% vs. …

The Perfect Storm: Substance Abuse, Mental Illness, And Rural America, Bailey D. Barnes

Faculty Publications

Across the United States in the late twentieth and early twenty-first century, substance abuse and mental illness have clashed with the criminal justice system to produce inequitable and tragic results. The War on Drugs especially affects rural communities, where resources for rehabilitative services, mental health treatment, and transitional housing are scarce. In these areas, the significant strain on the criminal justice system caused by the frequent intersection of substance abuse and mental illness has wrought overcrowded correctional facilities, congested criminal court dockets, exhausted public defenders, and devastated families. This Article is a case study of one such rural community's experience …

Current State Of Inclusion Education: A Cross-State Analysis Of Compliance, Teacher Certification, And Students With Disabilities Academic Outcomes, Emily Rose Winters

Doctoral Dissertations and Projects

Since passage of the Individuals with Disabilities Education Act (IDEA) there has been a legal requirement to provide students with disabilities the most inclusive education possible (Winchell et al., 2018) while Every Student Succeeds Act of 2015 requires that education be delivered by highly qualified teachers. Despite this, there have been minimal parameters set by the federal government in relation to inclusion education implementation or what constitutes a highly qualified teacher leading to significant variance in state inclusion education methods (Westling, 2019) and requirements for initial teaching certification or licensure (United States Department of Education, 2019; Youngs et al., 2003). …

Can A Lack Of Early Attachment To A Primary Caregiver Contribute To Aged-Out Kinship Foster Youth Sexual Employment?, Judith M. Malik

Doctoral Dissertations and Projects

This study investigated the relationship between lack of early attachment with a primary caregiver and survival sex employment in aged-out kinship care youth. Literature has shown that multiple situations have occurred to AFCY. While in kinship care, youth may have experienced physical abuse, sexual abuse, neglect, inappropriate discipline, and exposure to domestic violence, homicide, and pornography. Of the estimated 250,000 children who exited kinship care in 2018, 49% were reunited with their natural parent or primary caretaker, 25% were adopted, 11% went to live with a guardian, 7% were aged out, 7% went to live with another relative, and 1% …

Substance Abuse's Impact On Public Accounting, William Dennis Holmes

Doctoral Dissertations and Projects

A case study was performed to determine best practices for handling substance use disorder (SUD) when the problem occurs in business. SUD is a common problem that affects most businesses. The problem can result in high costs to businesses and is often difficult to navigate. The problem identified in the study was investigated by answering the primary research questions established in the planning stages of the study. An exhaustive literature review was performed on the topic, and common themes were discovered during a review of the literature. After the planning stage, the researcher performed a case study. Interviews of 23 …

The Effects Of Epistemic Beliefs On Undergraduate Students' Emotions And Attitudes Towards Genetically Modified Foods, David Andrew Lee

Doctoral Dissertations and Projects

Much research has explored socio-scientific issues (SSIs) in science instruction, including the connections between conceptions and attitude. Studies have also shown that epistemic beliefs affect epistemic emotions, which are a key component of students’ reaction to complex scientific topics. Correcting misconceptions can also result in emotional and attitude change, particularly surrounding the topic of genetically modified foods (GMFs). However, the impact of epistemic beliefs on emotions and attitude towards GMFs has largely gone unexplored. The purpose of this study is to examine the effects of epistemic beliefs on epistemic emotions and attitudes towards GMFs. This quantitative correlational study sampled 78 …

Learning Loss In Passage Reading Fluency For Elementary Students During Covid-19 School Closure, David Neil Stone

Doctoral Dissertations and Projects

The onset of the COVID-19 pandemic in 2020 caused public schools across the United States to suddenly close and interrupt face-to-face instruction for all students for a sustained period of time. It remains uncertain the total effect of the prolonged closure on student learning. This study provides a historical research review of the effect of previous school closures, such as traditional summer breaks and explores the phenomenon of learning loss that occurs when instruction is paused. This causal-comparative study examined the effect on passage reading fluency and reading comprehension of fourth grade elementary students following an unprecedented 24-week disruption of …

The Experiences Of African American Graduate Students Attending Colleges Of Chiropractic: A Hermeneutical Phenomenology, Darren De'un Howland

Doctoral Dissertations and Projects

The purpose of this hermeneutical phenomenological study is to discover and interpret the campus experiences of African American graduate students attending colleges of chiropractic in the United States. A sense of belonging within a campus environment is essential to all students that encounter a university. The campus environment has an important role in the retention of African American students. The theory guiding this study is the Culturally Engaging Campus Environment Model which examines cultural engagement within the campus environment. The central question leading this research study asks, “What are the lived experiences of African American graduate students attending colleges of …

The Interactive Effects Of Temperature And Nutrients On A Spring Phytoplankton Community, Stephanie I. Anderson, Gayantonia Franzè, Joshua D. Kling, Paul Wilburn, Colin T. Kremer, Susanne Menden-Deuer, Elena Litchman, David A. Hutchins, Tatiana A. Rynearson

Graduate School of Oceanography Faculty Publications

A complex interplay of environmental variables impacts phytoplankton community composition and physiology. Temperature and nutrient availability are two principal factors driving phytoplankton growth and composition, but are often investigated independently and on individual species in the laboratory. To assess the individual and interactive effects of temperature and nutrient concentration on phytoplankton community composition and physiology, we altered both the thermal and nutrient conditions of a cold-adapted spring phytoplankton community in Narragansett Bay, Rhode Island, when surface temperature was 2.6°C and chlorophyll > 9 μg L−1. Water was incubated in triplicate at −0.5°C, 2.6°C, and 6°C for 10 d. At each temperature, …

Parent-Of-Origin Effects Propagate Through Networks To Shape Metabolic Traits, Juan F. Macias-Velasco, Celine L.St Pierre, Jessica P. Wayhart, Li Yin, Larry Spears, Mario A. Miranda, Caryn Carson, Katsuhiko Funai, James M. Cheverud, Clay F. Semenkovich, Heather A. Lawson

Biology: Faculty Publications and Other Works

Parent-of-origin effects are unexpectedly common in complex traits, including metabolic and neurological traits. Parent-of-origin effects can be modified by the environment, but the architecture of these gene-by-environmental effects on phenotypes remains to be unraveled. Previously, quantitative trait loci (QTL) showing context-specific parent-of-origin effects on metabolic traits were mapped in the F16 generation of an advanced intercross between LG/J and SM/J inbred mice. However, these QTL were not enriched for known imprinted genes, suggesting another mechanism is needed to explain these parent-of-origin effects phenomena. We propose that non-imprinted genes can generate complex parent-of-origin effects on metabolic traits through interactions with imprinted …

Conserving The American Man: Gender, Eugenics And Education In The Civilian Conservation Corps, Charles Tocci, Ann Marie Ryan

Education: School of Education Faculty Publications and Other Works

The Civilian Conservation Corps (CCC) was a novel United States federal education programme that enrolled nearly three million men during the 1930s and early 1940s. This public work relief programme provides a case study of the ways that masculine, eugenicist ideas concerning public education evolved from the Progressive Era through the Great Depression. This educational philosophy was espoused by a small group of men – some educators, some not – who sought to remedy what they saw as the failures of public schooling, namely its overly feminine nature. Through an analysis of their public writings and the images that were …

Pathways From Child Maltreatment To Proactive And Reactive Aggression: The Role Of Post-Traumatic Stress Symptom Clusters, Elizabeth M. Mcrae, Laura Stoppelbein, Sarah E. O'Kelley, Paula K. Fite, Shana B. Smith

Research, Publications & Creative Work

Objective: Childhood aggression is related to a myriad of negative concurrent and long-term outcomes. To mitigate the risks associated with childhood aggression, it is important to understand risk factors that might predispose one to aggressive behaviors. One risk factor commonly associated with aggression is the experience of child maltreatment. A common outcome associated with child maltreatment is the development of post-traumatic stress symptoms (PTSS). Several prevailing theoretical models of both post-traumatic stress and aggression indicate that these constructs have similar underlying cognitive, behavioral, and emotional mechanisms. Therefore, the present study examined the relations between and among child maltreatment, PTSS clusters, …

Molecular Epidemiology Of Mycobacterium Tuberculosis Complex Strains In Urban And Slum Settings Of Nairobi, Kenya, Glennah Kerubo, Perpetua Ndungu, Yassir Adam Shuaib, Evans Amukoye, Gunturu Revathi, Susanne Homolka, Samuel Kariuki, Matthias Merker, Stefan Niemann

Pathology, East Africa

Kenya is a country with a high tuberculosis (TB) burden. However, knowledge on the genetic diversity of Mycobacterium tuberculosis complex (MTBC) strains and their transmission dynamics is sparsely available. Hence, we used whole-genome sequencing (WGS) to depict the genetic diversity, molecular markers of drug resistance, and possible transmission clusters among MTBC strains in urban and slum settings of Nairobi. We analyzed 385 clinical MTBC isolates collected between 2010 and 2015 in combination with patients’ demographics. We showed that the MTBC population mainly comprises strains of four lineages (L1–L4). The two dominating lineages were L4 with 55.8% (n = 215) and …

How To Engage Voluntary Spirit Possession Rituals In Mission: The Case Of The Dendi Adorcism Ritual, Michée Badé

Journal of Adventist Mission Studies

Missionaries face unique challenges when confronted with spirit possession rituals. Because not all spirit possessions are regarded as negative in some cultures, some spirit possessions are sought through adorcism rituals. Such spirit possessions are considered advantageous for the individual or the community. Contrasted with exorcism which is to expel or bind troublesome or uninvited entities, adorcism creates or strengthens beneficial ties between the possessed person and the spirits (Openshaw 2020:6).

This article seeks to show that the practice of adorcism rituals, as is the case among the Dendi people in the northern part of Benin, presents a unique challenge to …

Targeting Mitochondrial Respiration And The Bcl2 Family In High-Grade Myc-Associated B-Cell Lymphoma, Giulio Donati, Micol Ravà, Marco Filipuzzi, Paola Nicoli, Laura Cassina, Alessandro Verrecchia, Mirko Doni, Simona Rodighiero, Federica Parodi, Alessandra Boletta, Christopher P Vellano, Joseph R Marszalek, Giulio F Draetta, Bruno Amati

Faculty, Staff and Student Publications

Multiple molecular features, such as activation of specific oncogenes (e.g., MYC, BCL2) or a variety of gene expression signatures, have been associated with disease course in diffuse large B-cell lymphoma (DLBCL), although their relationships and implications for targeted therapy remain to be fully unraveled. We report that MYC activity is closely correlated with-and most likely a driver of-gene signatures related to oxidative phosphorylation (OxPhos) in DLBCL, pointing to OxPhos enzymes, in particular mitochondrial electron transport chain (ETC) complexes, as possible therapeutic targets in high-grade MYC-associated lymphomas. In our experiments, indeed, MYC sensitized B cells to the ETC complex I inhibitor …

Interleukin-6 Blockade Abrogates Immunotherapy Toxicity And Promotes Tumor Immunity, Ahmed Omar Kaseb, Elshad Hasanov, Hop Sanderson Tran Cao, Lianchun Xiao, Jean-Nicolas Vauthey, Sunyoung S Lee, Betul Gok Yavuz, Yehia I Mohamed, Aliya Qayyum, Sonali Jindal, Fei Duan, Sreyashi Basu, Shalini S Yadav, Courtney Nicholas, Jing Jing Sun, Kanwal Pratap Singh Raghav, Asif Rashid, Kristen Carter, Yun Shin Chun, Ching-Wei David Tzeng, Divya Sakamuri, Li Xu, Ryan Sun, Vittorio Cristini, Laura Beretta, James C Yao, Robert A Wolff, James Patrick Allison, Padmanee Sharma

Faculty, Staff and Student Publications

BACKGROUND: Hepatocellular carcinoma has high recurrence rates after surgery; however, there are no approved standard-of-care neoadjuvant or adjuvant therapies. Immunotherapy has been shown to improve survival in advanced hepatocellular carcinoma; we therefore aimed to evaluate the safety and tolerability of perioperative immunotherapy in resectable hepatocellular carcinoma.

METHODS: In this single-centre, randomised, open-label, phase 2 trial, patients with resectable hepatocellular carcinoma were randomly assigned (1:1) to receive 240 mg of nivolumab intravenously every 2 weeks (for up to three doses before surgery at 6 weeks) followed in the adjuvant phase by 480 mg of nivolumab intravenously every 4 weeks for 2 …

Metabolic Stress Induces Gd2+ Cancer Stem Cell-Like Phenotype In Triple-Negative Breast Cancer, Appalaraju Jaggupilli, Stanley Ly, Khoa Nguyen, Vivek Anand, Bin Yuan, Fouad El-Dana, Yuanqing Yan, Zoe Arvanitis, Danthasinghe Waduge Badrajee Piyarathna, Nagireddy Putluri, Helen Piwnica-Worms, Henry Charles Manning, Michael Andreeff, V Lokesh Battula

Faculty, Staff and Student Publications

Background: Metabolic stress resulting from nutrient deficiency is one of the hallmarks of a growing tumour. Here, we tested the hypothesis that metabolic stress induces breast cancer stem-like cell (BCSC) phenotype in triple-negative breast cancer (TNBC).

Methods: Flow cytometry for GD2 expression, mass spectrometry and Ingenuity Pathway Analysis for metabolomics, bioinformatics, in vitro tumorigenesis and in vivo models were used.

Results: Serum/glucose deprivation not only increased stress markers but also enhanced GD2+ BCSC phenotype and function in TNBC cells. Global metabolomics profiling identified upregulation of glutathione biosynthesis in GD2high cells, suggesting a role of glutamine in the BCSC phenotype. Cueing …

Stem Cell Architecture Drives Myelodysplastic Syndrome Progression And Predicts Response To Venetoclax-Based Therapy, Irene Ganan-Gomez, Hui Yang, Feiyang Ma, Guillermo Montalban-Bravo, Natthakan Thongon, Valentina Marchica, Guillaume Richard-Carpentier, Kelly Chien, Ganiraju Manyam, Feng Wang, Ana Alfonso, Shuaitong Chen, Caleb Class, Rashmi Kanagal-Shamanna, Justin P Ingram, Yamini Ogoti, Ashley Rose, Sanam Loghavi, Pamela Lockyer, Benedetta Cambo, Muharrem Muftuoglu, Sarah Schneider, Vera Adema, Michael Mclellan, John Garza, Matteo Marchesini, Nicola Giuliani, Matteo Pellegrini, Jing Wang, Jason Walker, Ziyi Li, Koichi Takahashi, Joel D Leverson, Carlos Bueso-Ramos, Michael Andreeff, Karen Clise-Dwyer, Guillermo Garcia-Manero, Simona Colla

Faculty, Staff and Student Publications

Myelodysplastic syndromes (MDS) are heterogeneous neoplastic disorders of hematopoietic stem cells (HSCs). The current standard of care for patients with MDS is hypomethylating agent (HMA)-based therapy; however, almost 50% of MDS patients fail HMA therapy and progress to acute myeloid leukemia, facing a dismal prognosis due to lack of approved second-line treatment options. As cancer stem cells are the seeds of disease progression, we investigated the biological properties of the MDS HSCs that drive disease evolution, seeking to uncover vulnerabilities that could be therapeutically exploited. Through integrative molecular profiling of HSCs and progenitor cells in large patient cohorts, we found …

Furthering Women In Policing: How A Police Department's Duty Firearm Selection Process May Mitigate The Gender Disparity In Marksmanship, Jenna Prochnau

Honors Program: Senior Projects (Public)

Previous research has revealed that there are several benefits to increasing the representation of women in law enforcement, including less use of force, increased community trust, and better outcomes for domestic violence and sexual assault victims. While many police departments now recognize these benefits and are aiming to recruit more women, a problem persists because women are less likely to graduate from police academies than their male counterparts. A significant difference has been observed in the area of marksmanship, particularly, with more female recruits failing to meet firearm scoring standards. Currently, very little is known about how police departments select …

Chronic Estrus Disrupts Uterine Gland Development And Homeostasis, C Allison Stewart, M David Stewart, Ying Wang, Rachel D Mullen, Bonnie K Kircher, Rui Liang, Yu Liu, Richard R Behringer

Faculty, Staff and Student Publications

Female mice homozygous for an engineered Gnrhr E90K mutation have reduced gonadotropin-releasing hormone signaling, leading to infertility. Their ovaries have numerous antral follicles but no corpora lutea, indicating a block to ovulation. These mutants have high levels of circulating estradiol and low progesterone, indicating a state of persistent estrus. This mouse model provided a unique opportunity to examine the lack of cyclic levels of ovarian hormones on uterine gland biology. Although uterine gland development appeared similar to controls during prepubertal development, it was compromised during adolescence in the mutants. By age 20 weeks, uterine gland development was comparable to controls, …