Digital Commons Network^™

Serum Protein Signatures For Breast Cancer Detection In Treatment-Naïve African American Women Using Integrated Proteomics And Pattern Analysis, Padma Tadi Uppala, Elmer Rivera, Hyun J. Kwon, Sharon S. Lum

Faculty Publications

Breast cancer is the leading cause of cancer-related mortality in African American (AA) women. In this study we evaluated the serum proteomic profile of AA women with breast cancer using an integrated proteomic framework with multivariate pattern analysis. Using 2D-DIGE, thousands of serum protein spots were detected across 33 gels; 46 spots met criteria for presence, statistical significance, and differential expression. Proteins from the spots were identified by MALDI-TOF/TOF and matched in curated databases, highlighting serum biomarkers including ceruloplasmin, alpha-2-macroglobulin, complement component C3 and C6, alpha-1-antitrypsin, alpha-1B-glycoprotein, alpha-2-HS-glycoprotein and haptoglobin-related protein. LC-MS/MS analysis revealed 163 differentiating peptides after imputing and …

Queer, Black & Churched: Exploring Black Lgbtq+ Lived Experience And Spirituality Through Free Verse Poetry And Music, Kei Slaughter

Music and Health Case Studies

This arts-based qualitative pilot study explored the lived experiences of queer Black adults (ages 29–43) and their relationship to the Black Church. Using critical narrative inquiry, six participants completed semi-structured interviews; three also created free verse poems reflecting on their experiences. I created a musical composition in response to participants' narratives. Analysis of participant interviews and poems revealed five themes: the church as formative; queer-antagonistic rhetoric and spiritual harm; community and belonging; Black queer joy; and music as a spiritual pathway. Notably, all participants described gospel music as having an abiding influence on their spiritual and artistic identities, even when …

The Relationship Between Physical Activity, Sleep, And Hallucinations In Adults With Charles Bonnet Syndrome, Jarrod Hollis, Rohit Narayan, Eldre W. Beukes, Rosie Lindsay, Aliyah Bharwani, Umair Mughal, Ikra Yaqoob, Justin A. Haegele, Scott Muriden, Peter M. Allen

Human Movement Studies & Special Education Faculty Publications

Physical activity levels, hallucination experiences, sleep quality, and perceived stress were assessed using a survey administered to 57 adults with a confirmed diagnosis of Charles Bonnet Syndrome (CBS). Physical activity demonstrated a significant negative correlation with hallucination severity (r = –0.335, p = 0.011, two-tailed). A significant negative correlation was also observed between physical activity and perceived stress (r = –0.497, p < 0.001, two-tailed). In contrast, no significant association was identified between hallucination frequency and sleep disruption or insomnia. These findings suggest that engaging in appropriate levels of physical activity may help reduce the severity of hallucinations and mitigate stress among individuals with CBS. The observation that higher levels of physical activity are associated with reduced hallucination burden may help the development of evidence-based management strategies for CBS. Additionally, the finding that physical activity was significantly related to hallucination severity, whereas sleep disruption was not, merits deeper exploration in future research.

The Best Practice Guide For Early Childhood Education And Care Food Environment: Module 4: Staff And Family Engagement (Version 1.0), Staff And Family Engagement Consortium

Research outputs 2022 to 2026

Engaging with families is a core responsibility of ECEC services and staff. By building positive, personal relationships with families, ECEC staff are able to share concerns or queries about the children in their care in a sensitive way.

One of the more sensitive topics that can come up is food – what they are eating, how much they are eating, their eating behaviours and skills, and everything in between. Through quick conversations at drop-off or via formal communication platforms, services can share a range of information about a child’s eating patterns and behaviours, and also gather information from families to …

The Best Practice Guide For Early Childhood Education And Care Food Environment: Module 1: Mealtime Environment And Practices (Version 1.0), Mealtime Environment And Practices Consortium

Research outputs 2022 to 2026

Mealtimes in early learning settings are more than a routine to help children eat. They are important opportunities for connection, learning and development, and for supporting children’s confidence and comfort around food and eating. At the same time, services must balance safety, regulatory requirements, diverse developmental and cultural needs, family expectations and practical constraints such as time and staffing.

The Mealtime Environment and Practices (MEP) module has been developed to support Early Childhood Education and Care settings (ECEC), for children from birth to 5 years, to create mealtimes that are safe, calm, inclusive and responsive to each child, while reflecting …

Syntax, Newsletter Of The Suffolk University English Department, Issue 16, Fall 2025, English Department

Syntax Newsletter of the Suffolk University English Department

No abstract provided.

Language, Literature, And Culture Newsletter, Twelfth Edition (January 2026), Language, Literature, And Culture Department, Clark University

Language, Literature, and Culture

The twelfth issue of the Language, Literature, and Culture department newsletter, which went out in January 2026. The Language, Literature, and Culture department newsletter aims to "share stories, news, ideas, achievements, and important information about and within our academic department that can be helpful to the campus community at large".

A Data-Driven Framework For Automation Readiness In Minnesota State University, Mankato Course Scheduling, Prisca Bongu Payanzo Maba

All Graduate Theses, Dissertations, and Other Capstone Projects

University course scheduling is one of the most complex optimization problems in higher education institutions. With universities growing in size and offering a broad spectrum of majors and disciplines, the number of possible course scheduling combinations increases exponentially, rendering traditional ways of scheduling ineffective.

Although operations research has extensively studied automated scheduling algorithms, there has been limited investigations into the organization readiness of academic departments to implement such systems. This paper offers a hybrid data science framework that assesses departmental readiness for scheduling automation.

The study combines qualitative Zoom interview data from 19 academic departments with institutional scheduling rules from …

A Kaleidoscope Of Sentiments, Emily Hartman

English Senior Capstone

This is a Creative Writing portfolio with many different genres and themes.

Reflections On Linear B, (Part 15): Sign 81 In Linear A And The Egyptian Four-Headed Ram God, Gerald Leonard Cohen

Arts, Languages and Philosophy Faculty Research & Creative Works

This article makes several tentative suggestions, including:

1. Linear A sign 81 (antecedent of Linear B81) may be an abbreviated image (two heads) of the four-headed Egyptian ram god Banebdjedet, with the horizontal line designating his horns shifted downward to the middle of the character.

2. A few other Linear A characters (e.g., sign 305) may represent slight alterations of sign A81.

3. Linear A82 includes two sets of three short horizontal lines. Those might signify brightness, and in the case of Banebdjedet the brightness would be his wisdom.

Celebration Of Faculty Scholarship 2025, Olin Library

Celebration of Faculty Scholarship

No abstract provided.

2025-2026 Book-In-Common Teaching Guide, Collin College

Book in Common

Introduction: Let's surround our students and community members this coming academic year with some common reading amongst the disciplines. 5 This year, we're reading Hua Hsu's Stay True. Not only is this book a Pulitzer-Prize winning memoir, but it's also a coming-of-age story about college life, friendship, music, identity, grief, race, 90's pop culture, philosophers, and technology. It's bound to be of interest to students as they, too, are encountering challenges of the day.

Genomic Surveillance: Your Dna Is Not Neutral, You Don’T Even Own It., Uri Kim

Mitchell Hamline Law Journal of Public Policy and Practice

No abstract provided.

Impact Of Oxidative Stress On Mapk Signaling In Human Pancreatic Ductal Cell Line, Alexis Fink

Theses

The main processes linked to diabetes (type 1 or type 2) and obesity are impaired insulin production and glucose intolerance. The imbalance between antioxidant defense systems and oxygen-reactive species are known as oxidative stress. Understanding oxidative stress and its substantial effects on diabetes is crucial. Reactive oxygen species (ROS) can activate mitogen-activated protein kinases (MAPKs). We hypothesize that altered MAPK phosphorylation and hence downstream signaling is associated with changes in oxidative stress in the human pancreatic duct epithelial cell line (H6C7). While H6C7 cells are often engineered to be cancerous precursors, the natural phenotype of these cells and their expression …

Exploring Interpenetrating Networks Derived From Compostable Polymers In Separations, Hailey Holshouser

Theses

The increasing demand for environmentally friendly and sustainable water treatment technologies drives the development of membranes that work to balance mechanical durability, tunable selectivity, and long-term stability. In this exploratory work, an interpenetrating polymer network (IPN) membrane system composed of poly(butylene adipate-co-terephthalate) (PBAT) and poly(2-hydroxyethyl methacrylate) (pHEMA) was developed to provide a more compostable and compatible platform for advanced separation applications. While the compostability of the entire framework was not tested, the dominant presence of PBAT in the matrix makes the membrane intrinsically favorable for composting. Mechanochemical Ionic Electrochromic Generators (IEGens) were synthesized and incorporated into the PBAT backbone for …

Effects Of Energetic State On Male Mating Preferences In Poeciliid Fishes With Differing Mating Strategies, Katherine E. Taylor

Theses

Reproduction is energetically costly, making condition (i.e., energetic state) a potential factor in shaping reproductive behavior. However, its role in male mate choice remains largely unexplored. Here, we investigate condition-dependent effects on male mate choice in two species of Poeciliids: one coercive species (Gambusia affinis) and one courting species (Xiphophorus hellerii). Diet treatments were used to manipulate male and female conditions, and male preferences were assessed in dichotomous-choice tests using animated female stimuli. X. hellerii males showed a preference for high-condition females, whereas G. affinis males showed no overall net preference. Diet influenced preference in G. affinis, with high-fed males …

2025 - 2026 Faculty Senate Annual Report, University Of South Carolina

Faculty Senate

The primary file includes the 2025 - 2026 Admissions Committee Report. Additional annual reports are attached.

Experience And Barriers In Pediatric Dysphagia Rehabilitation: A Quantitative Survey Study, François-Xavier Brajot, Ai-Ju Wu, Pao-Chuan Torng

Rehabilitation Practice and Science

Purpose: Despite an important need for health care services targeting pediatric dysphagia, there exist a number of barriers to doing so, including workforce competence. The current study surveyed practicing Speech-Language Pathologists to determine (1) the importance of pediatric dysphagia in their caseload, (2) the adequacy of existing educational resources, and (3) perceived barriers to providing quality care in Taiwan.

Methods: An anonymous survey was completed by Speech-Language Pathologists working in Taiwan. Responses were analyzed with respect to current work setting, experience, preparation, and perceived barriers.

Results: Survey results from 122 respondents indicated that the pediatric dysphagia caseload is unexpectedly low …

College Of Liberal Arts Faculty Bylaws 2026-2027 - Amended 09/2026), College Of Liberal Arts Faculty, Rollins College

College of Liberal Arts Bylaws

No abstract provided.

Winter 2026, Southwestern Oklahoma State University Office Of Institutional Advancement And Alumni

Echoes from the Hill

From The Interim President

Fellow members of the SWOSU Community,

I have been grateful for the opportunity to serve Southwestern Oklahoma State University for nearly three decades. As the Spring 2026 semester gets underway, we welcome the opportunity to pause and reflect on what we have learned—and what we continue to achieve together.

The bonds formed among our students, faculty, and staff as we deliver high quality, affordable programs of instruction and training are deep and enduring. The Southwestern Spirit—marked by friendly cooperation, thoughtful inquiry, and hard work—gives SWOSU a distinctive strength and instills in our graduates a lasting sense …

Spring/Summer 2026, Southwestern Oklahoma State University Office Of Institutional Advancement And Alumni

Echoes from the Hill

From The President

SWOSU Community,

SWOSU is 125 years old this year, and 2026 has been an exciting year here on the Hilltop! We are gearing up for a great Fall Semester!

This issue of Echoes highlights the wonderful time we had in the Spring when our students, faculty, and staff joined donors, alumni, dignitaries, and community leaders from throughout Oklahoma and beyond for the dedication of the Jerry & Margaret Hodge Center for Pharmacy & Rural Health. The Center represents an innovative private-public partnership that will enable our university to graduate more healthcare professionals to meet the workforce needs …

Reply To: S. N. Katkuri Et Al. And H. Liu Et Al. On Early And Sustained Improvements In Sense Of Smell With Tezepelumab Treatment In Patients With Chronic Rhinosinusitis With Nasal Polyps (Waypoint), Joaquim Mullol, Joseph K. Han, Tanya M. Laidlaw, Claire Hopkins, Anju T. Peters, Oliver Pfaar, Martin Desrosiers, Stella E. Lee, Andrew P. Lane, Claudia Chen, Yun Chon, Sandhia S. Ponnarambil, Andrew Foster, Andrew W. Lindsley, Christopher S. Ambrose

Department of Otolaryngology (ENT) Faculty Publications

[Introduction] We thank Dr. S. N. Katkuri, Dr. H. Liu, and their coauthors [1, 2] for their interest in our recent publication describing the improvements in loss of smell symptoms with tezepelumab versus placebo in patients with uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) in the WAYPOINT trial (NCT04851964) [3]. We are grateful for the authors' feedback on the clinical significance of the data presented and their appreciation of the consistency observed across a range of baseline clinical characteristic and demographic subgroups.

Early And Sustained Improvements In Sense Of Smell With Tezepelumab Treatment In Patients With Chronic Rhinosinusitis With Nasal Polyps (Waypoint), Joaquim Mullol, Joseph K. Han, Tanya M. Laidlaw, Claire Hopkins, Anju T. Peters, Oliver Pfaar, Martin Desrosiers, Stella E. Lee, Andrew P. Lane, Claudia Chen, Yun Chon, Sandhia S. Ponnarambil, Andrews Foster, Andrew W. Lindsley, Christopher S. Ambrose

Department of Otolaryngology (ENT) Faculty Publications

Background

Loss of smell is a principal symptom of chronic rhinosinusitis with nasal polyps (CRSwNP), affecting health-related quality of life and posing a safety hazard.

Methods

WAYPOINT (NCT04851964), a phase 3, multicenter trial in adults with uncontrolled CRSwNP, randomized patients 1:1 to receive tezepelumab 210 mg or placebo subcutaneously every 4 weeks for 52 weeks. Changes from baseline in biweekly mean Nasal Polyposis Symptom Diary (NPSD) loss of smell item, University of Pennsylvania Smell Identification Test (UPSIT), and 22-item Sino-Nasal Outcome Test (SNOT-22) loss of smell/taste item scores, as well as anosmia (UPSIT score ≤18) prevalence, were assessed over 52 …

Use Of Tezepelumab For Chronic Rhinosinusitis With Nasal Polyps By Eosinophilic Endotype: Waypoint Post-Hoc Analysis, Shigeharu Fujieda, Nobuyoshi Otori, Joseph K. Han, Tadataka Yabuta, Claudia Chen, Claudio Marchese, Andrews Foster, Sandhia S. Ponnarambil, Yun Chan, Brian J. Lipworth

Department of Otolaryngology (ENT) Faculty Publications

Background

The phase 3 WAYPOINT study (NCT04851964) reported that tezepelumab improved outcomes in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), including nasal polyp size, nasal congestion, and sinonasal symptoms, and reduced the need for surgery and systemic corticosteroids (SCS).

Objective

To evaluate the efficacy and safety of tezepelumab across Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis-defined eosinophilic chronic rhinosinusitis (ECRS) subgroups.

Methods

Adults with severe CRSwNP were randomized to tezepelumab 210 mg or placebo every 4 weeks. Coprimary end points were the change from baseline to week 52 in total Nasal Polyp Score and the biweekly mean Nasal …

High Strain Rate Behavior Of Soft Polymeric Materials : Polymer-Bonded Explosive Simulants And Polyimide Aerogels, Benjamin Jeffrey Solomon

Theses

Soft polymeric materials exhibit strain sensitive behaviors and are used in various applications where dynamic loading conditions may be present, making understanding the responses at high rates vital to safe application. Investigation of the mechanical response of soft materials at high strain rates has proven challenging due to low forces, mismatching impedances, and longer times to obtain dynamic force equilibrium limiting the quality and accuracy of data acquisition. Two polymeric materials were evaluated in this study. The first is polymer-bonded explosive (PBX) 9501, which experiences dynamic loading during use as solid propellant and warhead explosive material. It is found that …

Discovering The Genes And Molecular Mechanisms Involved In Increasing The Expression Of The Gad Regulon In Escherichia Coli Resistant To Macrolide Antibiotics, Lea V. Freeman

Theses

Various genes have been proposed to play a role in the action of indole, a bacterial hormone involved in biofilm and quorum sensing. Previous work found that E. coli strains carrying a macrolide-resistant mutation in the uL22 ribosomal protein reduce tna operon mRNA levels and, consequently, decrease indole production. This ribosomal mutation also increases expression of the gad regulon, a genetic unit involved in acid resistance at pH below 2. The gad regulon is involved in bacterial survival under environmental challenges, primarily regulating intracellular acid resistance, and its expression appears to depend on indole production. In this work, we work …

Association Between Internet Use For Health Information And Alzheimer’S Disease Diagnosis Among Older Adults With Diabetes In The United States: Examining Racial And Gender Disparities, Henry M. Zeidan

College of Graduate Studies: Theses & Dissertations

This study uses data from the National Health and Aging Trends Study (NHATS) Round 13, collected in 2024, to examine whether internet use for health information is associated with Alzheimer’s disease diagnosis among older adults with diabetes in the United States. Given the rising adoption of digital health, understanding who benefits from online health resources is increasingly important. The research also examines whether these associations differ across racial and gender groups, offering insight into potential disparities in digital health engagement and cognitive outcomes. Findings from this study will inform clinical practice, public health programming, and strategies to ensure equitable access …

The Psychiatric Burden Of Hidradenitis Suppurativa: A Trinetx Analysis Of Sex-Specific Disparities In Mental Health And Medication Use, Emily Sheetz, Julia Feord, Collette Sholi, Parker Adams, Tamas Gal, Susan G. Kornstein, Arturo Saavedra

Department of Medicine Faculty Publications

Background:

Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition associated with physical and psychological burden. Prior research has shown increased rates of depression and anxiety among individuals with HS; however, sex-based disparities in the prevalence of these mental health conditions in patients with HS remain underexplored.

Objective:

To evaluate sex-based differences in the prevalence of major depressive disorder (MDD), generalized anxiety disorder (GAD), and the prescribing of antidepressants and anxiolytics among patients with HS.

Methods:

Using the TriNetX database, we identified patients over the age of 18 who had a recorded diagnosis of HS. Propensity score matching based on …

Dietary Intake Of Micro- And Nanoplastics: Potential Adverse Gi Effects On Microbiome, Inflammation, And Neoplasia, Michael Saadeh, Gordon Hong, Sana Rabeeah, Priyata Dutta, Edward C. Oldfield, Iv, David A. Johnson

Department of Medicine Faculty Publications

Micro- and nanoplastics (MNPs) are pervasive in food-contact environments and the human diet, positioning the gastrointestinal (GI) tract as the primary portal of entry and a plausible site of early biological effects. Human exposure is supported by detection of microplastics in stool and colon tissue, and emerging clinical studies report associations between fecal microplastic burden and GI disease states, including inflammatory bowel disease (IBD) and colorectal cancer (CRC). Preclinical studies provide mechanistic plausibility, reporting that ingested MNPs can modulate microbial ecology, alter mucus membrane integrity, increase intestinal permeability through changes in cellular tight junction biology, and induce inflammatory gene expression. …

Association Of Valvular Disease Progression Using Echocardiographic Findings In A Large U.S. Cohort, Abes A. Bautista Neughebauer, Amin Yehya, Raymond L. Benza, Deepak Talreja

Department of Medicine Faculty Publications

Background

The prevalence of valvular disease in the US is approximately 2.5%. Given that over 5 million Americans are affected, it is crucial to find those at higher risk of progression. The goal of this paper is to uncover which patients are more likely to have valvular disease progression using demographic factors, EKG and echocardiogram (ECHO) findings.

Methods

This paper utilized the EchoNext Database, which pairs 100,000 electrocardiograms and echocardiograms based on specific structural heart disease labels. Univariate and multivariate logistic regression were used to find risk factors for progression for aortic stenosis (AS), aortic regurgitation (AR), mitral regurgitation (MR), …