Digital Commons Network^™

Evaluation Of A High School Wellness Center, Malka S. Moya

Theses and Dissertations

High school students are often burdened with academic, home, and peer stressors. With adolescent mental health issues and suicide on the rise, administrators have worked with nonprofits and the community to solve these problems. School-based wellness centers are tranquil rooms for students to decompress for up to 20 minutes during the school day with various sensory activities, calming nature scenes, and sounds for relaxation purposes. Wellness centers are meant to be a haven for self-regulation so students can come back to class with a calmer frame of mind. So far, there has not been a formal evaluation of school-based wellness …

Aorta In Pathologies May Function As An Immune Organ By Upregulating Secretomes For Immune And Vascular Cell Activation, Differentiation And Trans-Differentiation-Early Secretomes May Serve As Drivers For Trained Immunity, Yifan Lu, Yu Sun, Keman Xu, Fatma Saaoud, Ying Shao, Charles Drummer, Sheng Wu, Wenhui Hu, Jun Yu, Satya P Kunapuli, John R Bethea, Roberto I Vazquez-Padron, Jianxin Sun, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

Center for Translational Medicine Faculty Papers

To determine whether aorta becomes immune organ in pathologies, we performed transcriptomic analyses of six types of secretomic genes (SGs) in aorta and vascular cells and made the following findings: 1) 53.7% out of 21,306 human protein genes are classified into six secretomes, namely, canonical, caspase 1, caspase 4, exosome, Weibel-Palade body, and autophagy; 2) Atherosclerosis (AS), chronic kidney disease (CKD) and abdominal aortic aneurysm (AAA) modulate six secretomes in aortas; and Middle East Respiratory Syndrome Coronavirus (MERS-CoV, COVID-19 homologous) infected endothelial cells (ECs) and angiotensin-II (Ang-II) treated vascular smooth muscle cells (VSMCs) modulate six secretomes; 3) AS aortas upregulate …

Getting By With A Little Help From Friends: A Qualitative Case Study Of Students’ Strategies For Coping With Failure In An Undergraduate Biology Laboratory Course, Soo Won Shim, Nancy Pelaez

Purdue University Libraries Open Access Publishing Fund

Recent emphasis on research competencies in undergraduate biology education means that more students are doing course-based research. Professional research scientists learn from failed research, but undergraduate students who encounter failure in their biology lab research may not always respond in ways that advance their learning. There is a need to examine individual students’ responses to failed research as they conduct investigations in an undergraduate lab course. Here, we report a qualitative research case study based on data from interviews and course work to examine five undergraduate students’ emotional responses, coping strategies, and perceptions of learning as they confronted failure in …

Carveol Promotes Nrf2 Contribution In Depressive Disorders Through An Anti-Inflammatory Mechanism, Asmaa Jan Muhammad, Liangliang Hao, Lina Tariq Al Kury, Najeeb Ur Rehman, Arooj Mohsin Alvi, Haroon Badshah, Ikram Ullah, Fawad Ali Shah, Shupeng Li

All Works

Major depressive disorder (MDD) is a progressive deteriorating mental state with a feeling of worthlessness and frequent mood swings. Several studies reported the favorable effects of natural drug substances on MMD associated oxidative stress and neuroinflammation. The present study is attempted to examine whether carveol could affect lipopolysaccharide- (LPS-) induced depression, and if so, how nuclear factor E2-related factor (Nrf2) contributed to the neuroprotective effects of carveol mechanistically. Two experimental cohorts were used using the SD rats: first to evaluate the promising dose of carveol (whether 20 mg/kg or 50 mg/kg) and secondly to determine the effect of carveol on …

Viral Load And Cd4+ Among Hiv/Aids Patients Receiving Antiretroviral Therapy In Jayawijaya District, Papua Province, Indonesia, Mirna Widiyanti, Moch. Irfan Hadi, Setyo Adiningsih, Evi Iriani Natalia, Dedi Ananta Purba

Folia Medica Indonesiana

Hightlight:• Clinical conditions, CD4+ cell counts, and the viral copies number in the blood for AIDS/HIV were given antiretroviral therapy. • The profile of CD4+ levels and plasma viral load in HIV patients receiving antiretroviral therapy • The lower CD4+ cell counts and higher viral loads happen in HIV-infected's men. Abstract: Highly active antiretroviral therapy (HAART) is expected to reduce human immunodeficiency virus (HIV) morbidity and mortality. Antiretroviral therapy in HIV patients is given based on clinical conditions, CD4+ cell counts, and the number of viral copies in the blood. This study aimed to determine the profile of CD4+ levels …

Rare Diagnosis Of A Proliferating Pilar Tumor In A Facial Hairline Cryst, Farrah-Hani Imran, Nabilah Hasna Imami, Adzim Poh Yuen Wen

Folia Medica Indonesiana

Highlight: • Sebaceous cyst or epidermoid cyst is a benign capsulated tumour on the scalp region, face, neck, and trunk that subepidermal nodule filled with keratin. • Proliferating Pilar Tumours (PPT) are rare tumours was found in hair follicle. • Sebaceous cyst diagnose on facial hairline tumour turned out to be a rare Proliferating Pilar Tumour (PPT). Abstract: Sebaceous cyst, also known as an epidermoid cyst, is a subepidermal nodule filled with keratin and it is a benign capsulated tumor. It is often located on the scalp region, face, neck, and trunk; but can be found elsewhere such as the …

Movement Patterns Of Resident And Translocated Beavers At Multiple Spatiotemporal Scales In Desert Rivers, Emma Doden, Phaedra Budy, Tal Avgar, Julie Young

Wildland Resources Faculty Publications

Wildlife translocations alter animal movement behavior, so identifying common movement patterns post-translocation will help set expectations about animal behavior in subsequent efforts. American and Eurasian beavers (Castor canadensis; Castor fiber) are frequently translocated for reintroductions, to mitigate human-wildlife conflict, and as an ecosystem restoration tool. However, little is known about movement behavior of translocated beavers post-release, especially in desert rivers with patchy and dynamic resources. We identified space-use patterns of beaver movement behavior after translocation. We translocated and monitored nuisance American beavers in desert river restoration sites on the Price and San Rafael Rivers, Utah, USA, and compared …

Does Optic Flow Provide Information About Actions?, Hannah Masoner

Dissertations

Optic flow, the pattern of light generated in the visual field by motion of objects and the observer’s body, serves as information that underwrites perception of events, actions and affordances. This visual pattern informs the observer about their own actions in relation to their surroundings, as well as those of others. This study explored the limits of action detection for others as well as the role of optic flow. First-person videos were created using camera recordings of the actor’s perspective as they performed various movements (jumping jacks, jumping, squatting, sitting, etc.). In three experiments participants attempted to detect the action …

"It's A Part Of Who We Are" New Jersey Superintendents' Understandings Of And Approaches To Culturally Responsive District-Level Leadership, Danielle F. Mastrogiovanni

Seton Hall University Dissertations and Theses (ETDs)

A narrative study was used to examine the perspectives and experiences of Superintendents working towards educational justice by addressing the inequities found in schools. Data was collected through a series of semi-structured interviews representing a diverse participant pool of 23 superintendents and assistant superintendents who were currently employed in public school districts throughout the state of New Jersey. Using a primarily deductive coding scheme, the data was analyzed around the tenets of culturally responsive pedagogy and leadership.

Many participants described having impactful experiences as children that subsequently influenced their initial decision to become educators, as well as their leadership practices. …

Faculty Voices In Faculty-Led Programs Abroad, Tara M. Augspurger

Theses and Dissertations

This study focuses on the experiences and perceptions of faculty members who develop and lead study abroad programs for students enrolled in higher education institutions. Through qualitative case study inquiry, four questions are answered. First this study explores what motivates faculty members to become involved in the development and implementation of short-term study abroad programs. Second, faculty identify what was involved in creating and leading the short-term, faculty-led program including what obstacles they encountered and how they overcame them. Third, these faculty shared their perceptions of what students gained from participating in the program. Finally, this study investigates what institutions …

The Relationship Between Interparental Conflict, Family Attachment Style, And Young Adult Emotion Regulation, Kaylee Enevold

Theses and Dissertations

The purpose of the current study was to explore the relationship between interparental conflict, family attachment style, and young adult emotion regulation. Family attachment anxiety and avoidance (i.e., mother, father, and sibling) were expected to moderate the relationship between interparental conflict and young adult emotion regulation, such that better quality of mother, father, and sibling attachment anxiety and avoidance would indicate a weaker association between interparental conflict and difficulties in emotion regulation. There were 397 individuals from Illinois State University aged 18 to 22 who participated in the online survey. Three hierarchical multiple regression analyses were used to determine if …

Increased Dna Methylation, Cellular Senescence And Premature Epigenetic Aging In Guinea Pigs And Humans With Tuberculosis, Carly A Bobak, Abhimanyu, Harini Natarajan, Tanmay Gandhi, Sandra L Grimm, Tomoki Nishiguchi, Kent Koster, Santiago Carrero Longlax, Qiniso Dlamini, Jacquiline Kahari, Godwin Mtetwa, Jeffrey D Cirillo, James O'Malley, Jane E Hill, Cristian Coarfa, Andrew R Dinardo

Faculty, Staff and Students Publications

Background: Tuberculosis (TB) is the archetypical chronic infection, with patients having months of symptoms before diagnosis. In the two years after successful therapy, survivors of TB have a three-fold increased risk of death.

Methods: Guinea pigs were infected with Mycobacterium tuberculosis (Mtb) for 45 days, followed by RRBS DNA methylation analysis. In humans, network analysis of differentially expressed genes across three TB cohorts were visualized at the pathway-level. Serum levels of inflammation were measured by ELISA. Horvath (DNA methylation) and RNA-seq biological clocks were used to investigate shifts in chronological age among humans with TB.

Results: Guinea pigs …

Strainge: A Toolkit To Track And Characterize Low-Abundance Strains In Complex Microbial Communities, Lucas R Van Dijk, Bruce J Walker, Timothy J Straub, Colin J Worby, Alexandra Grote, Henry L Schreiber 4th, Christine Anyansi, Amy J Pickering, Scott J Hultgren, Abigail L Manson, Thomas Abeel, Ashlee M Earl

2020-Current year OA Pubs

Human-associated microbial communities comprise not only complex mixtures of bacterial species, but also mixtures of conspecific strains, the implications of which are mostly unknown since strain level dynamics are underexplored due to the difficulties of studying them. We introduce the Strain Genome Explorer (StrainGE) toolkit, which deconvolves strain mixtures and characterizes component strains at the nucleotide level from short-read metagenomic sequencing with higher sensitivity and resolution than other tools. StrainGE is able to identify strains at 0.1x coverage and detect variants for multiple conspecific strains within a sample from coverages as low as 0.5x.

Depletion Of Transmembrane Mucin 4 (Muc4) Alters Intestinal Homeostasis In A Genetically Engineered Mouse Model Of Colorectal Cancer, Ramesh Pothuraju, Priya Pai, Sanjib Chaudhary, Jawed A Siddiqui, Jesse L Cox, Sukhwinder Kaur, Satyanarayana Rachagani, Hemant K Roy, Michael Bouvet, Surinder K Batra

Faculty, Staff and Students Publications

Mucins are components of the mucus layer overlying the intestinal epithelial cells, which maintains physiological homeostasis. Altered mucin expression is associated with disease progression. Expression of MUC4 decreases in colorectal cancer (CRC); however, its functional role and implications in the intestinal pathology in CRC are not studied well. Therefore, we generated a genetically engineered Muc4 knockout (Muc4-/-) CRC mouse model by crossing with Muc4-/- and Apc^flox/flox mice in the presence of colon-specific inducible Cre. We observed that deficiency of Muc4 results in an increased number of macroscopic tumors in the colon and rectal region and leads to poor survival. …

Glynac (Glycine And N-Acetylcysteine) Supplementation In Mice Increases Length Of Life By Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities In Mitophagy And Nutrient Sensing, And Genomic Damage, Premranjan Kumar, Ob W Osahon, Rajagopal V Sekhar

Faculty, Staff and Students Publications

Determinants of length of life are not well understood, and therefore increasing lifespan is a challenge. Cardinal theories of aging suggest that oxidative stress (OxS) and mitochondrial dysfunction contribute to the aging process, but it is unclear if they could also impact lifespan. Glutathione (GSH), the most abundant intracellular antioxidant, protects cells from OxS and is necessary for maintaining mitochondrial health, but GSH levels decline with aging. Based on published human studies where we found that supplementing glycine and N-acetylcysteine (GlyNAC) improved/corrected GSH deficiency, OxS and mitochondrial dysfunction, we hypothesized that GlyNAC supplementation could increase longevity. We tested our hypothesis …

Ezh2 And Endometrial Cancer Development: Insights From A Mouse Model, Xin Fang, Nan Ni, Xiaofang Wang, Yanan Tian, Ivan Ivanov, Monique Rijnkels, Kayla J Bayless, John P Lydon, Qinglei Li

Faculty, Staff and Students Publications

Enhancer of zeste homolog 2 (EZH2), a core component of polycomb repressive complex 2, plays an important role in cancer development. As both oncogenic and tumor suppressive functions of EZH2 have been documented in the literature, the objective of this study is to determine the impact of Ezh2 deletion on the development and progression of endometrial cancer induced by inactivation of phosphatase and tensin homolog (PTEN), a tumor suppressor gene frequently dysregulated in endometrial cancer patients. To this end, we created mice harboring uterine deletion of both Ezh2 and Pten using Cre recombinase driven by the progesterone receptor …

A Red Fluorescent Protein With Improved Monomericity Enables Ratiometric Voltage Imaging With Asap3, Benjamin B Kim, Haodi Wu, Yukun A Hao, Michael Pan, Mariya Chavarha, Yufeng Zhao, Michael Westberg, François St-Pierre, Joseph C Wu, Michael Z Lin

Faculty, Staff and Students Publications

A ratiometric genetically encoded voltage indicator (GEVI) would be desirable for tracking transmembrane voltage changes in the presence of sample motion. We performed combinatorial multi-site mutagenesis on a cyan-excitable red fluorescent protein to create the bright and monomeric mCyRFP3, which proved to be uniquely non-perturbing when fused to the GEVI ASAP3. The green/red ratio from ASAP3-mCyRFP3 (ASAP3-R3) reported voltage while correcting for motion artifacts, allowing the visualization of membrane voltage changes in contracting cardiomyocytes and throughout the cell cycle of motile cells.

Profile Of Tuberculosis In Children In Taman District, Sidoarjo Regency, Indonesia, Ranti Dewanti Oktaviani, Pudji Lestari, Daniel Maranatha, Retno Asih Setyoningrum

Folia Medica Indonesiana

Highlight: • Pediatric tuberculosis patients profile using the medical records was determined. • The most pediatric tuberculosis patients under five years have pulmonary tuberculosis. • Pediatric tuberculosis patients received BCG immunization had a contact with adult tuberculosis patients histories. Abstract: The prevalence of tuberculosis (TB) in Indonesia is 391 per 100,000 population with the number of deaths around 110,000 cases in 2016. This study is descriptive research that aims to determine the profile of pediatric TB patients using the medical records at Taman public health center the period 2016-2019 with a total sampling technique. The sample in this study were …

Back Matter Vol.58 No.1 March 2022, Back Matter

Folia Medica Indonesiana

No abstract provided.

Sustaining The Seas, Rebecca Irelan

UNH Today Archive

No abstract provided.

Prioritizing Nurturing Care At The Municipal And District Level With The Brazilian Early Childhood Friendly Municipal Index (Imapi), Gabriela Buccini, Juliana L. Pimentel, Jéssica Pedroso, Stefanie Dos Anjos Coelho Kubo, Juracy Bertoldo, Alberto Sironi, Marcos E. Barreto, Rafael Perez-Escamilla, Muriel B. Gubert

Social and Behavioral Health Faculty Research

The Brazilian Early Childhood Friendly Municipal Index (IMAPI) is a population-based approach to monitor the nurturing care environment for early childhood development (ECD) using routine information system data. It is unknown whether IMAPI can be applied to document metropolitan urban territorial differences in nurturing care environments. We used Brasilia, Brazil's capital with a large metropolitan population of 2,881,854 inhabitants divided into 31 districts, as a case study to examine whether disaggregation of nurturing care data can inform a more equitable prioritization for ECD in metropolitan areas. IMAPI scores were estimated at the municipal level (IMAPI-M, 31 indicators) and at the …

Minority Nursing Students' Perceptions About Help-Seeking When Under Stress: A Basic Qualitative Study, Marjorie Attis-Josias

Dissertations

Nursing students experience many situations that lead to stress. Stress can have many adverse effects on students, including attrition, and minority nursing students often grapple with a unique set of stressors related to their status as minorities. This study was conducted to close the gap in the literature about minority nursing students' beliefs and attitudes about help-seeking for stress. A basic qualitative design was utilized to answer one research question, How do minority nursing students describe their experiences with help-seeking when under stress? Individual interviews were conducted with 12 ethnic and racial minority students enrolled in their third or fourth …

Four Scholarships Awarded At Council For Iwu Women Summit, Maria Harmon

News and Events (Discontinued Series)

No abstract provided.

Selection On Dispersal Drives Evolution Of Metabolic Capacities For Energy Production In Female Wing-Polymorphic Sand Field Crickets, Gryllus Firmus, Lisa A. Treidel, Gessen S. Quintanilla Ramirez, Dillon J. Chung, Michael Menze, Jose P. Vazquez-Medina, Caroline M. Williams

Faculty and Staff Scholarship

Life history and metabolism covary, but the mechanisms and individual traits responsible for these linkages remain unresolved. Dispersal capability is a critical component of life histories that is constrained by metabolic capacities for energy production. Conflicting relationships between metabolism and life histories may be explained by accounting for variation in dispersal and maximal metabolic rates. We used female wing-polymorphic sand field crickets, Gryllus firmus, selected either for long wings (LW) and flight-capability or short wings (SW) and high early lifetime fecundity to test the hypothesis that selection on dispersal capability drives the evolution of metabolic capacities. While resting metabolic …

Moderating Role Of Attention Control In The Relationship Between Academic Distraction And Performance, V. Deepa, R. Sujatha, Hasnan Baber

Higher Learning Research Communications

Objectives: The purpose of this study is to examine the influence of social media engagement, which includes frequency of using social media platforms (FSMP) and social media involvement, on the academic distraction and academic performance of the student. The study further tests the moderating role of attention control on the relationship between academic distraction and academic performance.

Method: Data were collected from 272 students studying in universities in India. Students answered questions on the frequency of visiting social media platforms and social media involvement, components of academic distraction, and attention control. AMOS software was used to test the structural model. …

Design Of A Week-Long Introduction To Engineering Summer Camp To Increase Interest And Eagerness Of Stem In Young Children, Beth Cannon

Honors Program: Senior Projects (Public)

For this creative project, a one-week camp curriculum was designed for elementary students (Grades 3-5) to introduce engineering. This work includes a rationale and camp curriculum. The rationale describes the research-based design of the curriculum. It outlines engineering basics and why and how to teach engineering to young students. The curriculum intends to introduce engineering to young children and excite the possibility of a future career. The following engineering disciplines are presented throughout the week of camp: mechanical, environmental, civil, electrical, and chemical. The first day of camp focuses on the basics of engineering. Following that, each day of camp …

An Overlooked Epidemic: Pediatric Oral Health Concerns On The Rise In Rural Communities, Emma Verbrugge

Honors Program: Senior Projects (Public)

Pediatric oral health is a concern for many dentists and parents as they lay the foundation for long-term proper hygiene in children. Early childhood caries (ECC) is a disease of chronic tooth decay marked as the most common chronic disease of childhood in the world. Children living in rural areas are even more susceptible to this disease and thus significant attention is needed to curve these numbers. The consequences of ECC are much more than just cosmetic, but include heightened risk of gingivitis, periodontal disease, diabetes, cardiovascular disease, and much more. A foundational cause of poor dental hygiene lies with …

The Akt Pathway And Satellite Cell Activation In Skeletal Muscle Mass Regulation, Santi Sofiyanti, Hanna Goenawan, Ronny Lesmana, Vita Murniati Tarawan

Folia Medica Indonesiana

Highlight: • AKT or protein kinase B increase protein synthesis and control the degradation of proteins. • Satellite cells was provided remarkable ability to regenerate skeletal muscle. • Stimulation of protein synthesis is effective therapy to maintain muscle mass, prevent muscle wasting to reduce risk sarcopenia and improve quality of life in the elderly. Abstract: Muscles have an important role as a regulator of glucose and triglyceride metabolism. Some researches show the correlation between skeletal muscle mass and metabolic diseases, such as diabetes. Skeletal muscle mass decrease occurs due to chronic illness or physiological process of aging, thus increasing the …

Anthropocene Fiction: Empathy, Kinship, And The Troubled Waters At The End Of The World, Megan Mandell Stowe

USF Tampa Graduate Theses and Dissertations

Anthropocene literature features characters and environments grappling with the devastation of climate change. Donna Haraway’s term Chthulucene narrows this category further by exposing the tentacular connections between overpopulation, dependence on material goods, species loss, and other facets of global warming—such as water as a resource. Three novels of the Chthulucene exhibit these connections, centering on the importance of water to both ecologies and personal identity. As seen in the novels, place attachment brings ecology and identity together by forging a stewardship between person and location, often resulting in efforts to defend and preserve a place. In Octavia Butler’s Parable of …

Interaction Analysis Of Mrp1 With Anticancer Drugs Used In Ovarian Cancer: In Silico Approach, Absarul Haque, Ghazanfar Ali Baig, Abdulelah Saleh Alshawli, Khalid Hussain Wali Sait, Bilal B. Hafeez, Manish Tripathi, Badrah Saeed Alghamdi, Hani S. H. Mohammed Ali, Mahmood Rasool

School of Medicine Publications

Multidrug resistance (MDR) is one of the major therapeutic challenges that limits the efficacy of chemotherapeutic response resulting in poor prognosis of ovarian cancer (OC). The multidrug resistance protein 1 (MRP1) is a membrane-bound ABC transporter involved in cross resistance to many structurally and functionally diverse classes of anticancer drugs including doxorubicin, taxane, and platinum. In this study, we utilize homology modelling and molecular docking analysis to determine the binding affinity and the potential interaction sites of MRP1 with Carboplatin, Gemcitabine, Doxorubicin, Paclitaxel, and Topotecan. We used AutoDock Vina scores to compare the binding affinities of the anticancer drugs against …