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Articles 150601 - 150630 of 822638

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Characterization Of Adaptations That Confer Increased Resistance To High Salinity In Brine Shrimp, Jasmine Hatcher-Moorman Mar 2022

Characterization Of Adaptations That Confer Increased Resistance To High Salinity In Brine Shrimp, Jasmine Hatcher-Moorman

Theses and Dissertations

Brine shrimp (Artemia salina) are osmoregulators that survive in ~4.5 M salt. Osmoregulating organs in brine shrimp are predicted to mimic a mechanism of osmoregulation in teleost fish involving NKA, NKCC, CFTR-like Cl- channels, and sodium-specific transport through tight paracelleular tight junctions in gut and gill epithelia. Pharmocological studies of low and high salt adapted brine shrimp show that key transporters involved in teleost fish osmoregulation are also vital to brine shrimp survival in hypersaline environments. Artemia express two Na/K pump isozymes formed by different α-submits associating with a common β-subunit. A “normal” α-subunit (α1NN) or a special α-subunit (α2KK) …

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20220318_Let's Talk About Menstrual Equity, Varina Kosovich Mar 2022

20220318_Let's Talk About Menstrual Equity, Varina Kosovich

HSLIC Blog Post

No abstract provided.

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Uncontrolled Mitochondrial Calcium Uptake Underlies The Pathogenesis Of Neurodegeneration In Micu1-Deficient Mice And Patients, Raghavendra Singh, Adam Bartok, Melanie Paillard, Ashley L. Tyburski, Melanie B Elliott, György Hajnóczky Mar 2022

Uncontrolled Mitochondrial Calcium Uptake Underlies The Pathogenesis Of Neurodegeneration In Micu1-Deficient Mice And Patients, Raghavendra Singh, Adam Bartok, Melanie Paillard, Ashley L. Tyburski, Melanie B Elliott, György Hajnóczky

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Dysregulation of mitochondrial Ca2+ homeostasis has been linked to neurodegenerative diseases. Mitochondrial Ca2+ uptake is mediated via the calcium uniporter complex that is primarily regulated by MICU1, a Ca2+-sensing gatekeeper. Recently, human patients with MICU1 loss-of-function mutations were diagnosed with neuromuscular and cognitive impairments. While studies in patient-derived cells revealed altered mitochondrial calcium signaling, the neuronal pathogenesis was difficult to study. To fill this void, we created a neuron-specific MICU1-KO mouse model. These animals show progressive, abnormal motor and cognitive phenotypes likely caused by the degeneration of motor neurons in the spinal cord and the cortex. We found increased susceptibility …

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Western Prairie Fringed Orchid Management, Ecology, And Decline At Mormon Island, Andrew J. Caven Mar 2022

Western Prairie Fringed Orchid Management, Ecology, And Decline At Mormon Island, Andrew J. Caven

Transactions of the Nebraska Academy of Sciences and Affiliated Societies

The western prairie fringed orchid (Platanthera praeclara Sheviak & M. L. Bowles; WPFO) was first detected in a vegetative state on Mormon Island in 1978 and identification was confirmed following a mass flowering event in 1982. From a high count of ~60 plants the WPFO slowly declined and has not been observed since 2000 despite flowering season surveys conducted in 15 of the last 20 years. We explore the natural history of the WPFO in the contexts of Mormon Island to establish potential causes for its apparent disappearance and evaluate the possibility it persists in some capacity. Our investigation …

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Editorial: Genomics-Enabled Triticeae Improvement, Xue-Feng Ma, Xianchun Xia, Shuyu Liu, P. Stephen Baenziger, Hakan Özkan Mar 2022

Editorial: Genomics-Enabled Triticeae Improvement, Xue-Feng Ma, Xianchun Xia, Shuyu Liu, P. Stephen Baenziger, Hakan Özkan

Department of Agronomy and Horticulture: Faculty Publications

No abstract provided.

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Survey Of Nationwide Public Perceptions Regarding Acceptance Of Wastewater Used For Community Health Monitoring In The United States., A. Scott Lajoie, Rochelle H. Holm, Lauren B. Anderson, Heather D. Ness, Ted Smith Mar 2022

Survey Of Nationwide Public Perceptions Regarding Acceptance Of Wastewater Used For Community Health Monitoring In The United States., A. Scott Lajoie, Rochelle H. Holm, Lauren B. Anderson, Heather D. Ness, Ted Smith

Faculty and Staff Scholarship

To assess the levels of infection across communities during the coronavirus disease 2019 pandemic, researchers have measured severe acute respiratory syndrome coronavirus 2 RNA in feces dissolved in sewer water. This activity is colloquially known as sewer monitoring and is referred to as wastewater-based epidemiology in academic settings. Although global ethical principles have been described, sewer monitoring is unregulated for health privacy protection when used for public health surveillance in the United States. This study used Qualtrics XM, a national research panel provider, to recruit participants to answer an online survey. Respondents (N = 3,083) answered questions about their knowledge, …

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The All-American Christ, Mark St George Mar 2022

The All-American Christ, Mark St George

Research Papers

My research identifies the mythogenesis of the myth-hero, the All-American Christ. This figure is realized through motion pictures by fusing together the ideological strains of Judeo-Christian vicarious redemption, Biblical American Exceptionalism, and conservative, Muscular Christianity. Using the methodologies of historical criticism and American studies, I argue that the construction of this conservative myth represents a militant manifestation of theocratic media, and is evangelized in the 1971 Christ film, The Omega Man, starring Charlton Heston.

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Critical-Thinking Experiences Of Chinese And U.S. College Students: A Comparative Analysis Using Phenomenology, Lu (Wendy) Yan Mar 2022

Critical-Thinking Experiences Of Chinese And U.S. College Students: A Comparative Analysis Using Phenomenology, Lu (Wendy) Yan

The Qualitative Report

In this study, I investigated the critical-thinking experiences of seven Chinese international and five U.S. students attending a large public university in the United States. I conducted a comparative analysis of these groups’ different experiences with critical thinking in this context, while closely following the twin methods of epoché and reduction in phenomenology to remain attuned to any personal biases. My results indicated that Chinese and U.S. students experienced critical thinking differently on the basis of the four universal existentials noted by van Manen (2016): lived experiences of relation (self–other), materiality (things), time, and space/place. Specifically, the Chinese students tended …

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Sustainable Manufacture Of Natural Fibre Reinforced Epoxy Resin Composites With Coupling Agent In The Hardener, Michelena A Hernandez, John Summerscales, Jasper Graham-Jones, Wayne Hall Mar 2022

Sustainable Manufacture Of Natural Fibre Reinforced Epoxy Resin Composites With Coupling Agent In The Hardener, Michelena A Hernandez, John Summerscales, Jasper Graham-Jones, Wayne Hall

School of Engineering, Computing and Mathematics

Lignocellulosic natural fibres are hydrophilic, while many matrix systems for composites are hydrophobic. The achievement of good mechanical properties for natural fibre-reinforced polymer (NFRP) matrix composites relies on good fibre-to-matrix bonding at the interface. The reinforcement is normally coated with an amphiphilic coupling agent to promote a strong interface. A novel alternative approach is to dissolve the coupling agent in the hardener for the resin before creating the stoichiometric mix with the base epoxy resin. During composite manufacture, the hydrophilic (polar) end of the coupling agent migrates to surfaces (internal interfaces) and bonds to the fibres. The hydrophobic (non-polar) end …

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Fluorescence Imaging Detection Of Nanodomain Redox Signaling Events At Organellar Contacts, David M. Booth, Péter Várnai, Suresh K Joseph, György Hajnóczky Mar 2022

Fluorescence Imaging Detection Of Nanodomain Redox Signaling Events At Organellar Contacts, David M. Booth, Péter Várnai, Suresh K Joseph, György Hajnóczky

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

This protocol describes how to visualize, detect, and analyze redox signals (oxidative bursts) at the ER-mitochondrial interface. It uses drug-inducible crosslinking to target the genetically encoded glutathione redox sensor Grx1roGFP2 to organellar contact sites to measure local redox changes associated with transient depolarizations of the mitochondrial membrane potential (flickers). The strategy allows imaging of the oxidized to reduced glutathione ratio (GSSG:GSH) in subcellular regions below the diffraction limit with good temporal resolution and minimum phototoxicity. Moreover, the strategy also applies to diverse parameters including pH, H2O2, and Ca2+.

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Antimicrobial Activity Of Zinc Oxide Nanoparticles Compared To Silver Nanoparticles Administered Towards Methicillin-Resistant Staphylococcus Aureus Biofilms, Kevin Núño Mar 2022

Antimicrobial Activity Of Zinc Oxide Nanoparticles Compared To Silver Nanoparticles Administered Towards Methicillin-Resistant Staphylococcus Aureus Biofilms, Kevin Núño

USF Tampa Graduate Theses and Dissertations

Zinc oxide nanoparticles (ZnO NPs), silver nanoparticles (AgNPs), and chitosan nanoparticles have strong antibacterial activity as a broad-spectrum antibiotic against multi-drug resistant (MDR) bacteria. MDR bacteria have a mechanism that increases antibiotic resistance through biofilm formations. MDR methicillin-resistant Staphylococcus aureus BAA-1720 was chosen for an in vitro assessment to calculate the biofilm reduction rate and the median effective dose (ED50) by performing biofilm quantification. Dynamic light scattering was chosen to determine the physiochemical characteristics of ZnO NPs, silver nanoparticles (AgNPs), and chitosan NPs. Transmission electron microscopy was conducted to verify each treatment’s physiochemical characteristics. Antimicrobial susceptibility testing of broad-spectrum and …

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Protocol For Single-Cell Isolation And Genome Amplification Of Environmental Microbial Eukaryotes For Genomic Analysis, Doina Ciobanu, Sandy Chan, Steven Ahrendt, C. Alisha Quandt, Gerald L. Benny, Matthew E. Smith, Timothy Y. James, Jan Fang Cheng Mar 2022

Protocol For Single-Cell Isolation And Genome Amplification Of Environmental Microbial Eukaryotes For Genomic Analysis, Doina Ciobanu, Sandy Chan, Steven Ahrendt, C. Alisha Quandt, Gerald L. Benny, Matthew E. Smith, Timothy Y. James, Jan Fang Cheng

Dartmouth Scholarship

We describe environmental microbial eukaryotes (EMEs) sample collection, single-cell isolation, lysis, and genome amplification, followed by the rDNA amplification and OTU screening for recovery of high-quality species-specific genomes for de novo assembly. These protocols are part of our pipeline that also includes bioinformatic methods. The pipeline and its application on a wide range of phyla of different sample complexity are described in our complementary paper. In addition, this protocol describes optimized lysis, genome amplification, and OTU screening steps of the pipeline. For complete details on the use and execution of this protocol, please refer to Ciobanu et al. (2021).

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Carbon Diversion, Partial Nitritation/Anammox Enrichment, And Ammonium Capture As Initial Stages For Mainstream Ion Exchange-Deammonification Process, Sheyla Chero-Osorio Mar 2022

Carbon Diversion, Partial Nitritation/Anammox Enrichment, And Ammonium Capture As Initial Stages For Mainstream Ion Exchange-Deammonification Process, Sheyla Chero-Osorio

USF Tampa Graduate Theses and Dissertations

Eutrophication is a concerning environmental problem worldwide that results in algae blooms, oxygen depletion, damages to aquatic life and public health, water quality issues, and loss of aesthetics in water reservoirs. Nutrient (e.g., nitrogen and phosphorus) discharges from wastewater, agricultural, urban, and residential runoff promote eutrophication in receiving water bodies. In terms of nitrogen removal, conventional biological nitrogen removal (BNR) is a common technique used in many wastewater treatment plants (WWTP). However, BNR requires aeration for nitrification and organic carbon input for denitrification. In WWTP, the aeration represents a considerable investment in terms of energy costs. Recent technologies involve applying …

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Food Consumption Frequency, Perceived Stress, And Depressive Symptoms Among Female University Students In Dubai, United Arab Emirates, Ohoud Mohamad, Haleama Al Sabbah, Linda Smail, Ehab W. Hermena, Rola Al Ghali Mar 2022

Food Consumption Frequency, Perceived Stress, And Depressive Symptoms Among Female University Students In Dubai, United Arab Emirates, Ohoud Mohamad, Haleama Al Sabbah, Linda Smail, Ehab W. Hermena, Rola Al Ghali

All Works

This study assessed whether perceived stress and depressive symptoms were associated with the frequency of consumption of specific food groups among female university students. A cross-sectional study was conducted among female university students using a simple random sampling method. The response rate was 97%, with a total number of 385 participants. The associations between stress levels and most/least-consumed food groups, and between depressive symptoms levels and most/least-consumed food groups were assessed. The questionnaire included a 12-item self-administered food frequency questionnaire, Cohen's Perceived Stress Scale, and the Beck Depression Inventory-II. The study was approved by the University Ethical Committee prior to …

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Spatially Resolved Transcriptomics Of High-Grade Serous Ovarian Carcinoma, Elaine Stur, Sara Corvigno, Mingchu Xu, Ken Chen, Yukun Tan, Sanghoon Lee, Jinsong Liu, Emily Ricco, Daniel Kraushaar, Patricia Castro, Jianhua Zhang, Anil K Sood Mar 2022

Spatially Resolved Transcriptomics Of High-Grade Serous Ovarian Carcinoma, Elaine Stur, Sara Corvigno, Mingchu Xu, Ken Chen, Yukun Tan, Sanghoon Lee, Jinsong Liu, Emily Ricco, Daniel Kraushaar, Patricia Castro, Jianhua Zhang, Anil K Sood

Faculty, Staff and Students Publications

Bulk and single-cell RNA sequencing do not provide full characterization of tissue spatial diversity in cancer samples, and currently available in situ techniques (multiplex immunohistochemistry and imaging mass cytometry) allow for only limited analysis of a small number of targets. The current study represents the first comprehensive approach to spatial transcriptomics of high-grade serous ovarian carcinoma using intact tumor tissue. We selected a small cohort of patients with highly annotated high-grade serous ovarian carcinoma, categorized them by response to neoadjuvant chemotherapy (poor or excellent), and analyzed pre-treatment tumor tissue specimens. Our study uncovered extensive differences in tumor composition between the …

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Skp2 Stabilizes Mcl-1 And Confers Radioresistance In Colorectal Cancer, Xinfang Yu, Li Zhou, Wenbin Liu, Lijun Liu, Feng Gao, Wei Li, Haidan Liu Mar 2022

Skp2 Stabilizes Mcl-1 And Confers Radioresistance In Colorectal Cancer, Xinfang Yu, Li Zhou, Wenbin Liu, Lijun Liu, Feng Gao, Wei Li, Haidan Liu

Faculty, Staff and Students Publications

Overexpression of Skp2 plays a critical role in tumorigenesis and correlates with poor prognosis in human malignancies. Thus, Skp2 has been proposed as an attractive target for anti-tumor interventions. The expression of Skp2 in human colorectal cancer (CRC) and the role of Skp2 in tumorigenic properties and irradiation sensitivities of CRC cells were examined by anchorage-dependent and -independent growth assays, immunoblot, flow cytometry, immunohistochemical staining, ubiquitination analysis, co-immunoprecipitation assay, CRISPR-Cas9-based gene knockout, and xenograft experiments. Skp2 is highly expressed in CRC patient tissues. Blocking Skp2 expression reduces the tumorigenic properties of CRC cells in vitro and in vivo. Depletion of …

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The Role Of Spatial Configuration In Enhancing The Environmental Ambiance For Devotional Ecstasy At Temple Towns Of Braj Mandal, Sunanda Kapoor, Vandana Sehgal, Mayank Mathur Mar 2022

The Role Of Spatial Configuration In Enhancing The Environmental Ambiance For Devotional Ecstasy At Temple Towns Of Braj Mandal, Sunanda Kapoor, Vandana Sehgal, Mayank Mathur

International Journal of Religious Tourism and Pilgrimage

Religious sites in Braj Mandal, India are visited by millions of pilgrims throughout the year. To meet the growing needs of pilgrims, rapid urbanisation is taking place with the result that there is change in the ancient spatial configuration. This research aims to explore the desired environmental ambiance for enhancing devotional ecstasy. The spatial configuration has been documented through physical mapping and visual preferences have been identified via a pilgrim opinion survey. Conclusions have been drawn regarding the identification of parameters of spatial configuration that enhance the environmental ambience for devotional ecstasy.

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Environmental Impact Of The Hajj, Abdullah Abonomi, Terry De Lacy, Joanne Pyke Mar 2022

Environmental Impact Of The Hajj, Abdullah Abonomi, Terry De Lacy, Joanne Pyke

International Journal of Religious Tourism and Pilgrimage

Every year, millions of Muslim worshippers visit Mecca in Saudi Arabia to perform Hajj which is the fifth and last pillar of Islam. In 2018, Mecca hosted more than 2,300,000 people from around 183 different countries and cultures. Based on the objective of Vision 2030 of the Saudi Arabian government, the number of pilgrims was planned to grow to 2.5 million in 2020, and the rate of increase was projected to be 13% per year. This goal, however, has not been achieved due to Covid-19. The pandemic forced the government to severely reduce the number of pilgrims in 2020 to …

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Ancient Religious Sites As Tools For Sustainable Tourism Development: An Empirical Study In The North Of Bali, I Made Pageh, Putu I. Rahmawati Ph.D, Terry Delacy Prof. Dr., Min Jiang Ph.D Mar 2022

Ancient Religious Sites As Tools For Sustainable Tourism Development: An Empirical Study In The North Of Bali, I Made Pageh, Putu I. Rahmawati Ph.D, Terry Delacy Prof. Dr., Min Jiang Ph.D

International Journal of Religious Tourism and Pilgrimage

Bali, a thousand temple island, is an ideal destination for spiritual tourism with magnificent temples containing a variety of unique religious carvings, statues, and ornaments. The beauty of Bali’s religious rituals, social and cultural events, and cultural performances underpin its spiritual tourism. An emerging body of literature has reported spiritual tourism and spiritual tourism is one of the pillars of sustainable tourism development (UNWTO, 2015). Religious tourism is a growing segment with significant economic impacts, however, limited research focuses on developing spiritual tourism and none of this in the North of Bali. This research takes a qualitative case study approach …

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Analysis Of Sir Epidemic Models With Sociological Phenomenon, Robert F. Allen, Katherine C. Heller, Matthew A. Pons Mar 2022

Analysis Of Sir Epidemic Models With Sociological Phenomenon, Robert F. Allen, Katherine C. Heller, Matthew A. Pons

Spora: A Journal of Biomathematics

We propose two SIR models which incorporate sociological behavior of groups of individuals. It is these differences in behaviors which impose different infection rates on the individual susceptible populations, rather than biological differences. We compute the basic reproduction number for each model, as well as analyze the sensitivity of R0 to changes in sociological parameter values.

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Innovation And Productivity: Is Learning By Doing Over?, Ružica Bukša Tezzele Mar 2022

Innovation And Productivity: Is Learning By Doing Over?, Ružica Bukša Tezzele

Economic and Business Review

Labour productivity is one of the key measures of economic performance. It represents the total volume of output produced per unit of labour. This paper examines the influence of business investments in research and development and education on labour productivity using system dynamics modelling. The results reveal that investments in education and training activities generate higher labour productivity growth. The impact of innovations largely depends on their diffusion and adoption that require educated and trained users. The new industrial era makes learning by doing quietly disappear and demand a great flexibility of workers and their ability to rapidly acquire new …

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Emerging Drug Targets And New Drugs In The Treatment Of Psoriatic Arthritis, Carmen Lariccia, Natalie Lennartz, Jessica Lewe, Jeffery Allison Mar 2022

Emerging Drug Targets And New Drugs In The Treatment Of Psoriatic Arthritis, Carmen Lariccia, Natalie Lennartz, Jessica Lewe, Jeffery Allison

Pharmacy and Wellness Review

Psoriasis is an autoimmune disease characterized by painful skin lesions. When joints and connective tissue also become involved, the condition is referred to as psoriatic arthritis (PsA). Current treatments for moderate to severe PsA include therapies used to treat rheumatoid arthritis (RA) despite differences in disease presentation which includes factors such as peripheral disease, sacroiliitis, stiffness, presence of rheumatoid factor and psoriasis. Treatment out-comes for PsA are measured by the American College of Rheumatology (ACR) Responder Index (ACR20) and the Dis-ease Activity Score for 28 joints (DAS28). First-line treatment includes disease-modifying antirheumatic drugs (DMARDs) such as methotrexate, sulfasalazine or leflunomide …

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Consensus Definition Of Misophonia: A Delphi Study, Susan E. Swedo, David M. Baguley, Damiaan Denys, Laura J. Dixon, Mercede Erfanian, Alessandra Fioretti, Pawel J. Jastreboff, Sukhbinder Kumar, M. Zachary Rosenthal, Romke Rouw, Daniela Schiller, Julia Simner, Eric A. Storch, Steven Taylor, Kathy R. Vander Werff, Cara M. Altimus, Sylvina M. Raver Mar 2022

Consensus Definition Of Misophonia: A Delphi Study, Susan E. Swedo, David M. Baguley, Damiaan Denys, Laura J. Dixon, Mercede Erfanian, Alessandra Fioretti, Pawel J. Jastreboff, Sukhbinder Kumar, M. Zachary Rosenthal, Romke Rouw, Daniela Schiller, Julia Simner, Eric A. Storch, Steven Taylor, Kathy R. Vander Werff, Cara M. Altimus, Sylvina M. Raver

Faculty and Student Publications

Misophonia is a disorder of decreased tolerance to specific sounds or their associated stimuli that has been characterized using different language and methodologies. The absence of a common understanding or foundational definition of misophonia hinders progress in research to understand the disorder and develop effective treatments for individuals suffering from misophonia. From June 2020 through January 2021, the authors conducted a study to determine whether a committee of experts with diverse expertise related to misophonia could develop a consensus definition of misophonia. An expert committee used a modified Delphi method to evaluate candidate definitional statements that were identified through a …

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Queueing Theory Model Of Pentose Phosphate Pathway, Sylwester M. Kloska, Krzysztof Pałczyński, Tomasz Marciniak, Tomasz Talaśka, Marissa Miller, Beata J. Wysocki, Paul H. Davis, Tadeusz A. Wysocki Mar 2022

Queueing Theory Model Of Pentose Phosphate Pathway, Sylwester M. Kloska, Krzysztof Pałczyński, Tomasz Marciniak, Tomasz Talaśka, Marissa Miller, Beata J. Wysocki, Paul H. Davis, Tadeusz A. Wysocki

Department of Electrical and Computer Engineering: Faculty Publications

Due to its role in maintaining the proper functioning of the cell, the pentose phosphate pathway (PPP) is one of the most important metabolic pathways. It is responsible for regulating the concentration of simple sugars and provides precursors for the synthesis of amino acids and nucleotides. In addition, it plays a critical role in maintaining an adequate level of NADPH, which is necessary for the cell to fight oxidative stress. These reasons prompted the authors to develop a computational model, based on queueing theory, capable of simulating changes in PPP metabolites’ concentrations. The model has been validated with empirical data …

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Workshop For Students Who Want To Get Involved In Undergraduate Research, March 22, Ohio University College Of Arts & Sciences Mar 2022

Workshop For Students Who Want To Get Involved In Undergraduate Research, March 22, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

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Biological Patent Thickets And Delayed Access To Biosimilars, An American Problem, Rachel Goode, Bernard Chao Mar 2022

Biological Patent Thickets And Delayed Access To Biosimilars, An American Problem, Rachel Goode, Bernard Chao

Sturm College of Law: Faculty Scholarship

Our study seeks to determine whether patent thickets covering biologic drugs are responsible for delayed biosimilar market entry. We compare patent assertions against the same biosimilar drugs across three countries. On average nine to twelves times more patents were asserted against biosimilars in the United States than in Canada and the United Kingdom. Biosimilars also enter the Canadian and UK markets more quickly than they do in the United States following regulatory approval. Later market entry is not a problem when the brand name drug company is asserting high quality patents (i.e. patents covering significant advances). Consequently, we drilled down …

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The Bison, March 17, 2022 Mar 2022

The Bison, March 17, 2022

The Bison Newspapers

No abstract provided.

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Nine Young Women Compete For The Title Of Miss Gardner-Webb, Office Of University Communications Mar 2022

Nine Young Women Compete For The Title Of Miss Gardner-Webb, Office Of University Communications

Gardner-Webb NewsCenter Archive

Held in honor of Women’s History Month, the focus of the Miss Gardner-Webb Pageant is “women empowerment, confidence, grace and sisterhood,” said coordinator, Jessika Raduly, associate director of Student Engagement. The pageant features nine young women, who will vie for the title on March 27 at 3 p.m. in Dover Theatre.

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Multiple Sclerosis: Relationship Between Locus Of Control And Quality Of Life In Persons With Low Versus High Disability, Judith Bijoux-Leist, Thomas P. Leist Mar 2022

Multiple Sclerosis: Relationship Between Locus Of Control And Quality Of Life In Persons With Low Versus High Disability, Judith Bijoux-Leist, Thomas P. Leist

Counseling & Psychological Services

Background: Health Locus of Control (HLOC) is the degree to which individuals believe that their health outcomes are controlled by 'external' factors - environmental forces, chance, fate, other people, or some higher power - or by 'internal' factors - their own behavior or action. Most of the literature on HLOC associates an Internal Health Locus of Control (IHLOC) to pro-health behaviors and better health outcomes. However, a few studies also suggest that in chronic illnesses, an External Health Locus of Control (EHLOC) could be beneficial with respect to pro-health behaviors and perceptions of Quality of Life (QoL), challenging assumptions about …

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Amphiphilic Cyclic Peptide [W4Kr5]-Antibiotics Combinations As Broad-Spectrum Antimicrobial Agents, Eman H. M. Mohammed, Sandeep Lohan, Rakesh K. Tiwari, Keykavous Parang Mar 2022

Amphiphilic Cyclic Peptide [W4Kr5]-Antibiotics Combinations As Broad-Spectrum Antimicrobial Agents, Eman H. M. Mohammed, Sandeep Lohan, Rakesh K. Tiwari, Keykavous Parang

Pharmacy Faculty Articles and Research

Linear and cyclic amphiphilic peptides, (W4KR5) and [W4KR5], were evaluated as antibacterial agents against Gram-positive and Gram-negative bacteria, including four multi-drug resistant strains and the corresponding four non-resistant strains. Cyclic peptide [W4KR5] showed higher antibacterial activity than the linear (W4KR5) counterpart. Cyclic [W4KR5] was subjected to combination (physical mixture or covalent conjugation) with meropenem as a model antibiotic to study the impact of the combination on antimicrobial activity. A physical mixture of meropenem and [W4KR5] showed …

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