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Targeted And Screening Based Approaches To Analyze Drm Transcriptional Repressor Complex Activity In Caenorhabditis Elegans, Emily Washeleski Jan 2026

Targeted And Screening Based Approaches To Analyze Drm Transcriptional Repressor Complex Activity In Caenorhabditis Elegans, Emily Washeleski

Dissertations, Master's Theses and Master's Reports

The molecular machinery that control the eukaryotic cell cycle, specifically the processes that mediate the switch between cellular division or quiescence, are essential for cellular and organismal viability. However, how the same machinery integrates with developmental or differentiation programs is less well understood. In Caenorhabditis elegans, the 8-subunit DRM complex (for Dp, Rb and MuvB), whose subunits belong to the Synthetic Mulitivulva (SynMuv) B class genes, is a central regulator of the cell cycle but also prevents inappropriate cell fate specification. The conserved mammalian DREAM complex (for Dp, Rb, E2F, And MuvB) is best known as a transcriptional repressor …


Physicochemical Characterization Of Small Extracellular Vesicles: Effects Of Immobilization, Isolation, And Disease State, Bianca M. Mercado Velez Jan 2026

Physicochemical Characterization Of Small Extracellular Vesicles: Effects Of Immobilization, Isolation, And Disease State, Bianca M. Mercado Velez

Dissertations, Master's Theses and Master's Reports

Cancer treatments and survival outcomes have improved significantly in the last couple of decades, with survival rates increasing in the U.S. Despite improvements in treatment outcomes, early detection and treatment are crucial for improving cancer prognosis and survival rates. The standard cancer diagnostic procedure of tissue biopsy is highly invasive, leading to the further spread of cancer in some cases. Alternatively, the extraction of biofluids from cancer patients, also called a liquid biopsy, is increasingly popular because it is less invasive and more representative of the tumor microenvironment, which contains cancer cells, tumor genetic material, and extracellular vesicles, including small …


Exploring Fructose Mimetics As Chemotherapeutic Potentiators: Impact On Glut5-Mediated Cancer Cell Vulnerability, Vedant Buwa Jan 2026

Exploring Fructose Mimetics As Chemotherapeutic Potentiators: Impact On Glut5-Mediated Cancer Cell Vulnerability, Vedant Buwa

Dissertations, Master's Theses and Master's Reports

Metabolic reprogramming toward increased sugar uptake is a hallmark of cancer, and fructose-specific uptake through the facilitative transporter GLUT5 is selectively upregulated in several adenocarcinomas, including breast and lung cancer. This dissertation develops and characterizes a panel of fluorescent fructose mimetics – the coumarin-based ManCou probes and the quinolinone-based ManQuin probes – as GLUT5-targeted reporters, cytotoxic effectors, and chemosensitization adjuvants, and establishes the boundaries within which each role holds.

The central experimental strategy pairs each GLUT5-targeted glycoconjugate with its sugar-free aglycone control, isolating transporter-mediated cytotoxicity from cytotoxicity intrinsic to the fluorophore itself. In luminal (MCF7) and triple-negative (MDA-MB-231) breast carcinoma, …


Tinjauan Frasa “Setiap Orang” Dalam Pasal 3 Ayat (1) Peraturan Pemerintah Nomor 56 Tahun 2021 Tentang Pengelolaan Royalti Hak Cipta Lagu Dan/Atau Musik, Fajar Hidayansyah Ilham, Luna Dezeana Ticoalu Jan 2026

Tinjauan Frasa “Setiap Orang” Dalam Pasal 3 Ayat (1) Peraturan Pemerintah Nomor 56 Tahun 2021 Tentang Pengelolaan Royalti Hak Cipta Lagu Dan/Atau Musik, Fajar Hidayansyah Ilham, Luna Dezeana Ticoalu

Jurnal Hukum & Pembangunan

Copyright is one form of legal protection for intellectual works, occupying an important position within the intellectual property law system. The Copyright Law explicitly grants exclusive rights to creators, encompassing both moral rights and economic rights. Economic rights, as stipulated in Article 9 paragraph (1), allow creators to obtain economic benefits from their works, ranging from publication, reproduction, distribution, performance, to communication to the public. This provision shows that creators hold a primary position as legal subjects entitled to protection, while also serving as central actors in the creative industry ecosystem. In practice, the mechanism for copyright protection requires implementing …


A Pilot Study Assessing The Oral Microbiome In Women Of Menopausal Age: Do Oral Nitrate–Reducing Bacteria Play A Role?, Katie Muddiman, Amazon Doble, Abish Stephen, Raul Bescos Garcia, Charlotte Illsley, Tomas Nicholas, Sally Hanks, Lisa Du Toit, Zoe Brookes Jan 2026

A Pilot Study Assessing The Oral Microbiome In Women Of Menopausal Age: Do Oral Nitrate–Reducing Bacteria Play A Role?, Katie Muddiman, Amazon Doble, Abish Stephen, Raul Bescos Garcia, Charlotte Illsley, Tomas Nicholas, Sally Hanks, Lisa Du Toit, Zoe Brookes

Peninsula Dental School

Introduction The links between oral health and female ageing are poorly understood, but many changes occur in the oral cavity of menopausal women that affect quality of life, and few current oral health interventions consider gender as part of their approach. The aim of this pilot study was to test the hypothesis that the oral microbiome and microenvironment change during female ageing and are thus worthy of further consideration both experimentally and clinically. Methods This observational pilot study retrospectively assessed women aged 18 to 89 years (n = 60) attending a UK primary care dental school facility for blood pressure …


Investigating The Determinants Of Fight Dynamics In The Minotaur Beetle Typhaeus Typhoeus, Amy Bromley Jan 2026

Investigating The Determinants Of Fight Dynamics In The Minotaur Beetle Typhaeus Typhoeus, Amy Bromley

School of Biological and Marine Sciences Theses

It is widely accepted that the main determinants of contest outcome are resource value, residency status, and resource holding potential, with each of these playing an important role in determining contest behaviour. Examples of resource holding potential are morphological traits such as body size and weaponry. Animals that possess weaponry can exhibit different morphotypes, such as size difference in horns, which can lead to differences in contest behaviour, with larger morphotypes engaging in head-to-head combat, while smaller morphotypes can avoid combat altogether. One such species that possess weapons in the form of horns and engages in physical combat, is the …


Investigating The Potential Utilisation Of Black Soldier Fly (Hermetia Illucens) As An Alternative Protein Source In Tilapia And Carp Feed, Sahya Maulu Jan 2026

Investigating The Potential Utilisation Of Black Soldier Fly (Hermetia Illucens) As An Alternative Protein Source In Tilapia And Carp Feed, Sahya Maulu

School of Biological and Marine Sciences Theses

Three experimental trials were conducted to evaluate defatted black soldier fly (BSF; Hermetia illucens) larvae meal and BSF frass as alternative protein ingredients. Defatted BSF larvae meal was tested in diets for both Nile tilapia (Oreochromis niloticus) and mirror carp (Cyprinus carpio), whereas BSF frass was assessed only in Nile tilapia.In the first experiment, dietary inclusion of 20% and 40% BSF meal, replacing mainly soybean meal (SBM) and corn gluten meal (CGM), was evaluated in Nile tilapia over 5 weeks. BSF improved growth and feed utilisation in a dose-dependent manner, increased posterior intestinal fold length, muscularis thickness, and goblet cell …


Physiological And Morphological Responses To Drought Stress In Different Cultivation Environments In Wild Type And Aba-Deficient Barley, Chloe Betts Jan 2026

Physiological And Morphological Responses To Drought Stress In Different Cultivation Environments In Wild Type And Aba-Deficient Barley, Chloe Betts

School of Biological and Marine Sciences Theses

Global food security is increasingly threatened by the effects of climate change. Of the environmental factors affected by climate change, drought is one of the most critical for plant survival and reproduction, shaping plant morphology and physiology and therefore crop productivity. Although the effects of drought on plants are widely studied, studies are often conducted in controlled greenhouse or laboratory conditions rather than more realistic field-like conditions. This is justified by the lower costs, convenience, and ability to disentangle the effects of different factors in more controlled conditions. This thesis explores the effect of the same watering limitations in different …


Plastic Pollution: Investigating Environmental Pathways And Critically Evaluating Interventions, Florence Parker-Jurd Jan 2026

Plastic Pollution: Investigating Environmental Pathways And Critically Evaluating Interventions, Florence Parker-Jurd

School of Biological and Marine Sciences Theses

Plastics are lightweight, versatile, and durable materials used in the manufacture of a wide range of products. Innovation in the early 1950’s facilitated a dramatic reduction in production costs with the potential to mass produce inexpensive convenience items intended for single use applications. As a consequence, plastic production has grown exponentially over the last 75 years, and a throw away culture of single use has become deeply engrained in modern society. Plastic production exceeds 450 million tonne/yr, substantially exceeding our capacity to manage associated waste resulting in pollution accumulating in every compartment of the natural environment. While plastic pollution has …


Coral Reef Fishes In Different Hard And Soft Coral-Dominated Reef Habitats, Ana Coelho Jan 2026

Coral Reef Fishes In Different Hard And Soft Coral-Dominated Reef Habitats, Ana Coelho

School of Biological and Marine Sciences Theses

Understanding how fish communities respond to different coral habitats is essential for predicting the future resilience of coral reef ecosystems. This study tested whether fish assemblages differ between hard and soft coral–dominated reef plots and among coral genera. We predicted higher fish abundance and more frequent benthic interactions in hard coral plots, and genus-specific differences in community composition, behaviour, and time spent within plots. This study examined fish species diversity, richness, abundance, behaviour, and the time spent in coral habitats. The analysis encompassed seven coral genera in an Indo-Pacific reef system. Twenty 2 × 2 m reef areas, each dominated …


Effects Of Salinity, Region, Site, And Cohort On Growth Traits Of The Black Mangrove, Avicennia Germinans, Bekki Foster Jan 2026

Effects Of Salinity, Region, Site, And Cohort On Growth Traits Of The Black Mangrove, Avicennia Germinans, Bekki Foster

School of Biological and Marine Sciences Theses

Mangroves are trees that are adapted to grow in saline or brackish environments, typically, in estuarine and coastal zones in tropical and subtropical areas. Their root complexity supports marine biodiversity by providing habitat and nursery grounds for fishes and their canopies serve as roosting and breeding sites for avian species. Additionally, roots facilitate nutrient capture through epibiont communities and trap suspended sediments, enhancing stability against high-energy weather and contributing to vertical accretion, potentially mitigating sea level rise. This study aimed to investigate how such factors as salinity, provenance, and genetic background, affect the above and below ground morphological traits of …


Influence Of Ecological Transitions On The Evolution Of Circadian And Light Detection Genes In Squamates, Isobel Sleep Jan 2026

Influence Of Ecological Transitions On The Evolution Of Circadian And Light Detection Genes In Squamates, Isobel Sleep

School of Biological and Marine Sciences Theses

Circadian rhythms are self-sustaining, endogenous processes that align behaviour and physiology with daily environmental cycles. Rhythms are regulated by conserved genes forming transcriptional feedback loops and are entrained by environmental cues (e.g., light). Circadian systems are well studied in model organisms, their molecular evolution in squamates (lizards and snakes) remains less understood. Squamates represent the most species-rich reptile group with extensive ecological and sensory diversity, exhibiting multiple independent transitions across ecological niches, including repeated shifts into low-light environments (e.g., nocturnality, fossoriality), making them ideal for examining circadian and light-associated gene evolution. This study investigates how ecological transitions have influenced the …


Large-Scale Coastal Dynamics: New Incites From Lidar And Satellite Remote Sensing, Aikaterini Konstantinou Jan 2026

Large-Scale Coastal Dynamics: New Incites From Lidar And Satellite Remote Sensing, Aikaterini Konstantinou

School of Biological and Marine Sciences Theses

This thesis leverages remote sensing methods to advance understanding of shoreline morphodynamics from storm to decadal timescales, focusing on three interrelated objectives. First, regional patterns and timescales of beach recovery following the extreme 2013/14 winter were quantified using bi-annual LiDAR and RTK-GNSS surveys of 23 south-west England sites. Recovery trajectories exhibited consistent patterns aligned with pre-existing storm response classifications, demonstrating that both storm response and post-storm recovery can be classified into four groups governed by intrinsic geomorphological and hydrodynamic controls. Almost 90% of sites had recovered at least 75% of lost sediment within three years, while some fully exposed beaches …


Trialing A Novel Method Of Skin Mucus Sampling To Measure Stress And Reproductive Steroid Hormones In Mobula Species Mobula Alfredi And Mobula Munkiana, Bethany Faulkner Jan 2026

Trialing A Novel Method Of Skin Mucus Sampling To Measure Stress And Reproductive Steroid Hormones In Mobula Species Mobula Alfredi And Mobula Munkiana, Bethany Faulkner

School of Biological and Marine Sciences Theses

Anthropogenic pressures, exacerbated by exceptionally slow population growth, have led to all mobulid species being listed on the IUCN Red List. Understanding stress and reproductive physiology is essential for improving mobulid conservation strategies. However, few studies have investigated the hormonal processes that underlie stress responses and reproductive physiology in mobulids. Studies on fish species have identified positive correlations between steroid hormone concentrations in blood and skin mucus, the collection of the latter being a much less invasive technique. This pilot study examined the feasibility of using skin mucus as a non-invasive matrix for detecting steroid hormones in two mobulid species. …


Impacts Of Microplastics In A Changing Agri-Environment, Riley Kent Jan 2026

Impacts Of Microplastics In A Changing Agri-Environment, Riley Kent

School of Biological and Marine Sciences Theses

Microplastics are increasingly recognized as persistent contaminants in terrestrial ecosystems, yet their impacts on plant performance remain poorly understood under realistic environmental conditions. In natural and agricultural systems, plants rarely encounter contaminants in isolation, instead experiencing multiple interacting stressors. The work presented in this thesis investigated how soil microplastics influence plant growth and physiology both independently and in combination with freshwater flooding, a climate-relevant stressor associated with increased storm activity and shifts in precipitation patterns. Using white clover (Trifolium repens) as a model agronomic legume across multiple cultivars, the study examined how polymer identity, plant genotype, and environmental context interact …


From Public To Policy How Jellyfish Data And Citizen Science Can Be Used For Biodiversity Management, John Terenzini Jan 2026

From Public To Policy How Jellyfish Data And Citizen Science Can Be Used For Biodiversity Management, John Terenzini

School of Biological and Marine Sciences Theses

Long term biodiversity data is necessary for detecting biological and ecological changes to marine ecosystems. The data can inform marine policy, yet data are often lacking for some species and traditional data collection approaches can be logistically challenging and expensive. Jellyfish are one taxon for which data are lacking, and data collection can be challenging due to their life history traits and the inherent challenges of marine research. This research aims to provide evidence for the importance of monitoring jellyfish, demonstrate the effectiveness of citizen science for monitoring jellyfish, and examine how jellyfish monitoring data can inform international frameworks. The …


Does In-Bed Cycling Delivered Within 48 Hours Of Mechanical Ventilation, Reduce The Occurrence Of Delirium In Critically Ill Patients: A Mixed-Methods Feasibility Randomised Controlled Trial Protocol, Jacqueline Bennion, Mark Hudson, Mary Hickson, Victoria Allgar, Bridie Kent, David Mcwilliams, Daniel Martin Jan 2026

Does In-Bed Cycling Delivered Within 48 Hours Of Mechanical Ventilation, Reduce The Occurrence Of Delirium In Critically Ill Patients: A Mixed-Methods Feasibility Randomised Controlled Trial Protocol, Jacqueline Bennion, Mark Hudson, Mary Hickson, Victoria Allgar, Bridie Kent, David Mcwilliams, Daniel Martin

Peninsula Medical School

Background: Delirium is a severe neuropsychiatric clinical state presenting as an acute onset of cognitive deficits. Patients receiving invasive mechanical ventilation (IMV), have the highest incidence (50%–80%) of delirium amongst patients admitted to intensive care units. Preliminary data indicates that early mobilisation is associated with reduced delirium in critically ill patients. However, definitive evidence is lacking. Current practice varies due to many barriers to patients, who require IMV, receiving early mobilisation interventions. In-bed cycling may address some of these barriers. This research aims to evaluate the feasibility and acceptability of early in-bed cycling to reduce delirium in critically ill patients. …


The Effectiveness Of Digital Therapeutics Intervention In Oral Anticoagulation Management: A Systematic Review And Meta-Analysis, Jiayue Guo, Lili You, Lu Liu, Xitong Jiao, Debasish Kar, Jitendra Jonnagaddala Jan 2026

The Effectiveness Of Digital Therapeutics Intervention In Oral Anticoagulation Management: A Systematic Review And Meta-Analysis, Jiayue Guo, Lili You, Lu Liu, Xitong Jiao, Debasish Kar, Jitendra Jonnagaddala

Peninsula Medical School

Objective: To summarize the key intervention characteristics and evaluate the effectivenessand safety of digital therapeutics (DTx) in patients receiving oral anticoagulation, witheffectiveness evaluated using time in therapeutic range (TTR), thromboembolic events (TEE),and mortality, and safety evaluated based on bleeding events.Patients and Methods: We searched PubMed, Embase, Web of Science, and the CochraneLibrary from inception to June 20, 2025, and identified ten randomized controlled trialsinvolving 7,237 patients. The criteria required studies to assess software-based DTxsupporting anticoagulation management and report effectiveness or safety outcomes. Studyquality was evaluated using the Grading of Recommendations, Assessment, Development,and Evaluation (GRADE) framework, and random-effects models were applied.Results: …


Current Status Of Aflatoxin Contamination And Mitigation Efforts In Mozambique: A Systematic Review, Ibraimo Teleha Chabite, Jamal Kussaga, Frida Nyamete, Rashid Suleiman Jan 2026

Current Status Of Aflatoxin Contamination And Mitigation Efforts In Mozambique: A Systematic Review, Ibraimo Teleha Chabite, Jamal Kussaga, Frida Nyamete, Rashid Suleiman

All Rsif Scholars' Publications

Aflatoxin continues to be a major problem for public health and trade in Mozambique. The use of products and sub-products based on maize, cassava, and groundnuts, which are susceptible to aflatoxin contamination is one of the main causes. This systematic review provides an overview of the current state of aflatoxin contamination and mitigation efforts in Mozambique. The study reviewed scientific articles published between 1st January 2004 and 31st July 2024 in peer reviewed journals, after conducting the evaluation process, 667 articles were excluded, and 68 articles fulfilled the inclusion criteria and were included in this review. Based on these included …


Detection Of Bacterial Internalization In Lettuce (Lactuca Sativa) Leaves Grown In Aquaponic Systems With Nile Tilapia (Oreochromis Niloticus) Under Microbial Challenge, Angélica Adiação Jossefa, Leonildo Dos Anjo Viagem, Karoline Moreira Barbuio, Brunno Da Silva Cerozi, Sebastian Wilson Chenyambuga Jan 2026

Detection Of Bacterial Internalization In Lettuce (Lactuca Sativa) Leaves Grown In Aquaponic Systems With Nile Tilapia (Oreochromis Niloticus) Under Microbial Challenge, Angélica Adiação Jossefa, Leonildo Dos Anjo Viagem, Karoline Moreira Barbuio, Brunno Da Silva Cerozi, Sebastian Wilson Chenyambuga

All Rsif Scholars' Publications

Aquaponic systems are increasingly recognized as sustainable technologies for integrated fish and vegetable production. However, concerns remain regarding the potential internalization of human pathogens into vegetables grown in these systems. This study assessed the risk of pathogen internalization in lettuce leaves grown in aquaponic systems with Nile tilapia challenged with Escherichia coli or Vibrio cholerae. The system comprised nine fish tanks, eighteen hydroponic pipes, and eighty-one lettuce plants, with tanks assigned to three treatments. Samples of water, fish gut, fish blood, and lettuce leaves were collected. Microbiological analyses included selective culture, biochemical assays, and molecular identification. Although colonies consistent with …


Bioeconomic Optimization Of Zinc And Iron Agronomic Biofortification In Cowpea (Vigna Unguiculata [L.] Walp.) In Mozambique Under Tropical Field Conditions, Tancredo José Carlos Carlos, Leonel Domingos Moiana, Omar Jorge Sabbag, Boniface Hussein J. Massawe Jan 2026

Bioeconomic Optimization Of Zinc And Iron Agronomic Biofortification In Cowpea (Vigna Unguiculata [L.] Walp.) In Mozambique Under Tropical Field Conditions, Tancredo José Carlos Carlos, Leonel Domingos Moiana, Omar Jorge Sabbag, Boniface Hussein J. Massawe

All Rsif Scholars' Publications

Agronomic biofortification with zinc (Zn) and iron (Fe) has emerged as a promising approach to enhance crop productivity while improving food and nutritional security. However, fertilizer recommendations based exclusively on maximum biological yield may not maximize farmers’ economic returns. This study integrated agronomic and economic analyses to identify the biologically and economically optimal Zn and Fe fertilization strategies for cowpea (Vigna unguiculata [L.] Walp.) under tropical field conditions in Mozambique. A randomized complete block design with a 3 × 4 × 4 factorial arrangement was used to evaluate three fertilization methods (soil, foliar, and combined soil + foliar) and …


Green Synthesis And Characterization Of Novel Nio/Sio2 Nanocomposites From Citrus Sinensis Extract As An Emulsion Stabilizer For Chemical Enhanced Oil Recovery Applications, Godfrey Osemudiamhen Eseigbe, Sunday Sunday Ikiensikimama Jan 2026

Green Synthesis And Characterization Of Novel Nio/Sio2 Nanocomposites From Citrus Sinensis Extract As An Emulsion Stabilizer For Chemical Enhanced Oil Recovery Applications, Godfrey Osemudiamhen Eseigbe, Sunday Sunday Ikiensikimama

All Rsif Scholars' Publications

Orange peels or Citrus sinensis peels are considered plant waste that can be discarded and become a nuisance to the environment. They can be used to create useful products that are economically advantageous. In this paper, Citrus sinensis peels extract was utilized to synthesize NiO/SiO2. The nanoparticles were characterised using various analytical methods including Scanning electron Microscopy (SEM), Electron Dispersed X-ray Fluorescence (EDXRF), Fourier Transform Infrared Spectroscopy (FTIR), Dynamic Light Scattering (DLS), and Thermogravimetric Analysis TGA. Based on the characterisation results, irregular NiO/SiO2 nanocomposites with an average diameter of 16.6 nm were observed via the XRD analysis. The DLS gave …


Evaluating Quahog (Mercenaria Mercenaria) Nursery Methods And Production Costs To Support Diversification Of Maine’S Fisheries And Aquaculture Sector, Hannah G. Wolf Jan 2026

Evaluating Quahog (Mercenaria Mercenaria) Nursery Methods And Production Costs To Support Diversification Of Maine’S Fisheries And Aquaculture Sector, Hannah G. Wolf

Honors Theses

Populations of wild and farmed quahogs in Maine are expanding, driven by warming waters, declining soft-shell clam populations, and the need to diversify fisheries. The Northern quahog (Mercenaria mercenaria) is a potential species to diversify Maine’s marine sector, as its geographical range is expanding, and they appear more resistant to green crab predation. Enhancing wild quahog stock provides economic and social advantages for both the aquaculture and wild harvest industries. However, there is limited understanding about the commercial viability of producing quahog seed on existing farms for wild shellfish enhancement in Maine. This research, part of a larger NOAA …


The Development And Pilot Evaluation Of An Out-Of-Hospital Immersive Birthing Simulation Training Application For Paramedics And Ambulance Officers Using Virtual-Reality Technology, Michella Hill Jan 2026

The Development And Pilot Evaluation Of An Out-Of-Hospital Immersive Birthing Simulation Training Application For Paramedics And Ambulance Officers Using Virtual-Reality Technology, Michella Hill

Theses: Doctorates and Masters

Out-of-hospital births (OOHBs) are births which occur outside a hospital setting. This includes planned home births attended by midwives, or unplanned OOHBs where the intention was to birth in a hospital or maternity centre, however, occurs in an unintended location. Prehospital clinicians, inclusive of registered paramedics and volunteer ambulance officers (VAOs) infrequently attend OOHBs, as most births occur in maternity wards as anticipated. OOHBs comprises < 1% of emergency ambulance requests and requires specialised skills for prehospital clinicians to competently manage birthing and potential complications. As exposure to birthing is so rare, these specialised skills and knowledge are underutilised and subject to rapid decay. Compounding the problem, obstetrics is infrequently taught across undergraduate education, in-service training, or within individual clinician’s continuing professional development. Placements shadowing midwives are scarce due to nursing and medical students receiving priority. Previous research regarding OOHBs is limited, nonetheless suggests prehospital clinicians are underprepared to manage an OOHB, which has serious patient safety implications. The present research sought to explore prehospital clinicians’ preparedness and confidence in managing OOHBs. It also investigates whether a digital training solution such as virtual reality (VR) simulation may reduce the theory-practice gap and assist in competency retention.

Publication one provides a comprehensive methodology outline which is applied to Study One; a scoping review of prehospital clinician and birth parent experiences with OOHBs. Risk factors, complications and interventions provided by prehospital clinicians, as …


Rock On Technology: Perspectives Of People With Neurological Conditions On Robot-Assisted Lower Limb And Gait Neurorehabilitation, Rachel G. Buckingham, Saran Chamberlain, Amanda Timler, Matthew K. Bagg, Nikki E. Bakhtazad, Taya Hamilton, Patricia Martinet, Bianca Haagman, Stuart I. Hodgetts, Barbara Singer, Ann Maree Vallence, Jodie Marquez, Eric Gaitho, Emma Gee, Jessica Nolan Jan 2026

Rock On Technology: Perspectives Of People With Neurological Conditions On Robot-Assisted Lower Limb And Gait Neurorehabilitation, Rachel G. Buckingham, Saran Chamberlain, Amanda Timler, Matthew K. Bagg, Nikki E. Bakhtazad, Taya Hamilton, Patricia Martinet, Bianca Haagman, Stuart I. Hodgetts, Barbara Singer, Ann Maree Vallence, Jodie Marquez, Eric Gaitho, Emma Gee, Jessica Nolan

Research outputs 2022 to 2026

Purpose: Explore perspectives of people living with neurological conditions in Western Australia (WA) on robot-assisted lower limb neurorehabilitation (RALLR), and implementation requirements. Materials and methods: This co-designed, qualitative descriptive study included people living with neurological conditions. In-person semi-structured focus groups (FGs) were facilitated by a person with lived experience of stroke. FGs were recorded, data were transcribed, and thematically analysed using a reflexive approach. Results: Five FGs included 24 participants (54.2% women, median age 50 years). Of these, thirteen participants had RALLR experience. Primary neurological conditions represented among participants comprised spinal cord injury (n = 11), stroke (n = 3), …


Colostrum As A Protective Factor Against Peanut Allergy: Evidence From A Birth Cohort, Maheshwar Bhasin, Matthew Cooper, Patricia Macchiaverni, Ravisha Srinivas Joys, Therese A. O'Sullivan, Jeffrey A. Keelan, Carina Venter, Debra J. Palmer, Adrian J. Lowe, Susan L. Prescott, Desiree Silva, Valerie Verhasselt Jan 2026

Colostrum As A Protective Factor Against Peanut Allergy: Evidence From A Birth Cohort, Maheshwar Bhasin, Matthew Cooper, Patricia Macchiaverni, Ravisha Srinivas Joys, Therese A. O'Sullivan, Jeffrey A. Keelan, Carina Venter, Debra J. Palmer, Adrian J. Lowe, Susan L. Prescott, Desiree Silva, Valerie Verhasselt

Research outputs 2022 to 2026

Background: Food allergy affects families' quality of life, can be lifelong and life-threatening, urging the identification of early modifiable risk factors. Formula feeding in the first days of life may increase the risk of cow's milk allergy, a risk often attributed to cow's milk allergens exposure. Early formula feeding also reduces the colostrum intake, the first 3 days' milk, which is rich in bioactive compounds critical for immune and gut health. This study investigates whether partial colostrum feeding increases the risk of food allergy beyond cow's milk. Methods: Data from 666 mother-infant pairs in the Australian ORIGINS cohort categorised neonates …


Deep Reinforcement Learning–Driven Multi-Omics Integration For Constructing Gtage: A Novel Aging Clock From Igg N-Glycome And Blood Transcriptome, Yao Xia, Syed Mohammed Shamsul Islam, Xingang Li, Abdul Baten, Xuerui Tan, Wei Wang Jan 2026

Deep Reinforcement Learning–Driven Multi-Omics Integration For Constructing Gtage: A Novel Aging Clock From Igg N-Glycome And Blood Transcriptome, Yao Xia, Syed Mohammed Shamsul Islam, Xingang Li, Abdul Baten, Xuerui Tan, Wei Wang

Research outputs 2022 to 2026

Previous studies have demonstrated that the immunoglobulin G (IgG) N-glycome and transcriptome are potential biochemical signatures of chronological and biological ages, and several aging clocks have been developed. By integrating the IgG N-glycome and transcriptome, we propose a novel aging clock, gtAge. We developed a deep reinforcement learning-based multiomics integration method called AlphaSnake. The results showed that AlphaSnake achieved a predicted coefficient of determination (R2) value of 0.853, outperforming the concatenation-based integration method (R2 = 0.820). The gtAge estimated by AlphaSnake explained up to 85.3% of the variance in chronological age, which was higher than that in …


Time To Hang Up The Gloves: A Scoping Review Of Evidence On Non-Sterile Glove Use During Intravenous Antimicrobial Preparation And Administration, Natasya Raja Azlan, Debbie Massey, Lesley Andrew, Amanda Towell-Barnard, Seng Giap Marcus Ang, Carol Crevacore, Martina Costello, Aaron Alejandro, Weiting Liu, Naila Zaman, Peta Anne Zimmerman Jan 2026

Time To Hang Up The Gloves: A Scoping Review Of Evidence On Non-Sterile Glove Use During Intravenous Antimicrobial Preparation And Administration, Natasya Raja Azlan, Debbie Massey, Lesley Andrew, Amanda Towell-Barnard, Seng Giap Marcus Ang, Carol Crevacore, Martina Costello, Aaron Alejandro, Weiting Liu, Naila Zaman, Peta Anne Zimmerman

Research outputs 2022 to 2026

Aims: To systematically summarise evidence related to the use of non-sterile gloves when preparing and administering intravenous antimicrobials. Design: Scoping review. Methods: A rigorous scoping review was undertaken following Arksey and O'Malley's (2005) framework and the modified Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for scoping review guidelines (2018). Five databases and grey literature were included in the search. Literature published between 2009 and 2024 was included. Data Sources: Five databases (Medline, CINAHL, EMBASE, Scopus and Web of Science) and the grey literature were searched in February 2024. Results: Three studies were included; however, none directly addressed correct …


Indigenous Stewardship And Co-Management In Action: A Case Study On Blue Carbon From A Mangrove Ecosystem On The Great Barrier Reef, Micheli D.P. Costa, I. Noyan Yilmaz, Pawel Waryszak, Rory Crofts, Melissa Wartman, Pere Masqué, Brian Singleton, Gavin Singleton, Ashlyn Skeene, Lucy Friend, Peter I. Macreadie Jan 2026

Indigenous Stewardship And Co-Management In Action: A Case Study On Blue Carbon From A Mangrove Ecosystem On The Great Barrier Reef, Micheli D.P. Costa, I. Noyan Yilmaz, Pawel Waryszak, Rory Crofts, Melissa Wartman, Pere Masqué, Brian Singleton, Gavin Singleton, Ashlyn Skeene, Lucy Friend, Peter I. Macreadie

Research outputs 2022 to 2026

Blue carbon ecosystems play a vital role in climate change mitigation and adaptation through their capacity to sequester and store organic carbon. Queensland, Australia, contains over 500,000 ha of mangroves, much of it under the stewardship of Traditional Custodians. The mangrove forests of the Bidakarra (Barron River) estuary provide a unique opportunity to demonstrate how Indigenous leadership, scientific research, and local industry partnerships can advance both ecological and cultural outcomes. We present a co-designed case study from Kukujum (Ellie Point), an area co-managed by Cairns Airport, Yirrganydji Gurabana Aboriginal Corporation, and the Yirrganydji Land and Sea Ranger Program through Dawul …


Metaverse And Artificial Intelligence As Web 4.0: The Next Generation Of The Internet, Anton Klarin, Elena Gorenskaia, Qijie Xiao, Pi-Shen Seet Jan 2026

Metaverse And Artificial Intelligence As Web 4.0: The Next Generation Of The Internet, Anton Klarin, Elena Gorenskaia, Qijie Xiao, Pi-Shen Seet

Research outputs 2022 to 2026

This study utilizes systems thinking to explore and entwine an evolving metaverse scholarship to a relatively underexplored phenomenon of Web 4.0. We adopt a soft systems thinking framework to guide the interpretation of complex and evolving metaverse scholarship, using bibliometric mapping of 5587 publications sourced from Scopus. Using systems thinking, we synthesize these clusters into the following four thematic areas: (i) business and society implications, (ii) optimization, (iii) integration with other technologies and (iv) metaverse education. Drawing on the largest-to-date review of the metaverse as well as a systematic review of Web 4.0 literature, we propose a novel conceptualization of …