Digital Commons Network^™

03-28-2022 Southmoore, Bridge Creek And Drummond Take Top Honors At Swosu Interscholastic Meet, Southwestern Oklahoma State University

THE BARK ARCHIVE 2022

No abstract provided.

Afrc Minutes 03/28/2022, Activity Fee Review Committee

Activity Fee Review Committee

No abstract provided.

The Sglt2 Inhibitor Canagliflozin Reduces Androgen Receptor Expression And Nuclear Localization Of Beta-Catenin In Human Prostate Cancer Cells, Kalkidan Bekele, Tunde Smith, Lamonica Stewart

Student Research

Drugs that inhibit the protein sodium-glucose cotransporter-2 (SGLT2) are commonly used in the United States to treat type 2 diabetes. Recent studies suggest that SGLT2 inhibitors reduce growth of lung, liver, and breast cancer cells in vitro. Therefore, administration of SGLT2 inhibitors may also limit the growth of malignant tumors. Previous work from our laboratory has shown that one SGLT2 inhibitor, canagliflozin, reduces the proliferation of C4-2B cells, a castration-resistant human prostate cancer cell line. Concentrations of canagliflozin that reduce proliferation also lower levels of the androgen receptor (AR), a protein known to promote growth of prostate cancers. The goal …

Effects Of Dibutyltin Exposures On Translation Regulatory Factor S6 In Human Immune Cells, Meaghan Lewis, Amanda Ruff, Margaret Whalen

Student Research

Dibutyltin is an organotin contaminating the environment through its use as a stabilizer in polyvinylchloride, PVC plastics. DBT has been found in drinking water and beverages, such as beer and wine, due to leaching from the PVC plastics used during the distribution of these drinks. Along with PVC plastics, DBT has been used as a deworming agent in poultry, infiltrating additional food products and increasing the exposure of the toxin to humans. Due to its multiple uses, it has entered the food chain and has been detected in human blood at levels as high as 0.3μM. Inflammatory cytokines are important …

Effect Of Solitary And Combined Use Of Cover Crops On Soilborne Disease Suppressiveness In Woody Ornamental Nursery Production Systems, Madhav Parajuli, Fulya Baysal-Gurel, Milan Panth

Student Research

Cover crops are known to be effective in reducing soilborne diseases in woody ornamentals. However, it remains unknown how solitary and combined uses of cover crops influence soilborne disease, and whether these effects differ with seed rate. The objective of this study was to explore the impacts of cover crops, in solitary and combined use, on soilborne disease suppressiveness in woody ornamental nursery production systems. Soils were sampled from the established red maple (Acer rubrum L.) plantation grown with and without cover crops [crimson clover (Trifolium incarnatum L.)] or triticale (× Triticosecale W.) or (their mixture)] following the cover crop …

Influence Of Soil And Foliar Application Of Fulvic Acid On Yield Parameters Of Organically Grown Bell Peppers (Capsicum Annuum L.) Under Open-Field Conditions In Tennessee, Pinkky Kanabar, Dilip Nandwani

Student Research

Due to increased demand for healthier fresh produce by consumers, growers are seeking for environmental friendlier techniques to improve sustainability and profitability in organic vegetable production. The use of fulvic acid biostimulant coupled with different mode of application can contribute to enhanced plant growth and high-quality yield. A field experiment was conducted in a randomized complete block design with three replications at the organic farm of Tennessee State University in summer 2021. The influence of foliar and soil application of fulvic acid biostimulant on yield of organically grown bell peppers (Capsicum annuum L.) was investigated. Transplants were raised from organic …

Protocol: A Scoping Review Of Graduate Student Education, Curriculum Impact, And Interest In Interdisciplinary Research Training, David D. Allen Iii

Faculty and Student Publications

Title: PROTOCOL: A Scoping Review of Graduate Student Education, Curriculum Impact, and Interest in Interdisciplinary Research Training

Background: Alongside traditional graduate education practices, implementing curriculum focused on providing interdisciplinary research training to graduate students may help support their academic development. This additional educational focus can bolster graduate student understanding of methodological practices, develop alternative routes of thinking or approaching a problem/ issue/ topic, may assist in developing student professional socialization skills, and may positively impact student internal motivations, beliefs, and perceptions.

Methods: Our scoping review protocol was developed a priori utilizing the Joanna Briggs Institute guidance, by …

Materials Science And Mechanosensitivity Of Living Matter, Alison E. Patteson, Merrill E. Asp, Paul A. Janmey

Physics - All Scholarship

Living systems are composed of molecules that are synthesized by cells that use energy sources within their surroundings to create fascinating materials that have mechanical properties optimized for their biological function. Their functionality is a ubiquitous aspect of our lives. We use wood to construct furniture, bacterial colonies to modify the texture of dairy products and other foods, intestines as violin strings, bladders in bagpipes, and so on. The mechanical properties of these biological materials differ from those of other simpler synthetic elastomers, glasses, and crystals. Reproducing their mechanical properties synthetically or from first principles is still often unattainable. The …

The Utah Statesman, March 28, 2022, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

2022-March-28-Jc Female Eagle Has A Name, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY, Tenn. (March 28, 2022) – The new lady American Bald Eagle residing in the Johnson City nest viewed by thousands via one of the East Tennessee State University Department of Biological Sciences’ Eagle Cams now has a name.

... and the winner is: Jolene!

The new female eagle who is currently incubating her first clutch of eggs at …

Faculty Senate Agenda And Minutes, March 28, 2022

Faculty Senate Minutes and Agendas

Agenda and minutes from the Wright State University Faculty Senate Meeting held on March 28, 2022

Organizational Silofication: Implications In Grouping Experts For Organizational Performance, Dave Silberman, Rob E. Carpenter, Elena Cabrera, Jasmine Kernaleguen

Human Resource Development Faculty Publications and Presentations

This paper offers that organizational underachievement sourced to workplace expertise is a product of bounded perspective constructed by the agency of expertise. Embedded in any bounded perspective is limitations to what can be seen. Organizations that seek to leverage expertise solely on their agency risk organizational silofication. We conclude that recognizing organizational silofication is an opportunity for organizations to address organizational underachievement by addressing the perspectives that create the hidden impediments limiting their overall potential.

Système De Gestion Des Risques Liés À La Fatigue Pour Les Policiers En Autopatrouille, Diane B. Boivin, Philippe Boudreau

Rapports de recherche scientifique

Dans les organisations à opérations continues, telles que les services d’urgence, plusieurs facteurs, d’ordre organisationnel et individuel, contribuent à générer de la fatigue physique et mentale chez les travailleurs. Le travail de nuit et rotatif occasionne une perturbation importante dans l’horaire de sommeil et d’éveil. Cette situation augmente le risque de baisse de performance, d’erreurs, d’incidents et d’accidents au travail en plus de réduire la productivité et la santé des travailleurs. Cette recherche s’insère dans une démarche paritaire ayant pour objectif de doter les services de police étudiés d’outils de gestion de la fatigue, scientifiquement validés. Ces outils leur permettront …

Correlational Networking Guides The Discovery Of Unclustered Lanthipeptide Protease-Encoding Genes, Dan Xue, Ethan Older, Zheng Zhong, Zhou Shang, Nanzhu Chen, Nolan Dittenhauser, Lukuan Hou, Peiyan Cai, Michael D. Walla, Shi-Hui Dong, Xiaoyu Tang, Hexin Chen, Prakash Nagarkatti, Mitzi Nagarkatti, Yong-Xin Li, Jie Li

Faculty Publications

Bacterial natural product biosynthetic genes, canonically clustered, have been increasingly found to rely on hidden enzymes encoded elsewhere in the genome for completion of biosynthesis. The study and application of lanthipeptides are frequently hindered by unclustered protease genes required for final maturation. Here, we establish a global correlation network bridging the gap between lanthipeptide precursors and hidden proteases. Applying our analysis to 161,954 bacterial genomes, we establish 5209 correlations between precursors and hidden proteases, with 91 prioritized. We use network predictions and co-expression analysis to reveal a previously missing protease for the maturation of class I lanthipeptide paenilan. We further …

Hiv-Related Stigma, Sexual Identity, And Depressive Symptoms Among Msm Living With Hiv: A Moderated Mediation Modeling Analysis, Tianyue Mi, Guanghua Lan, Xueying Yang Ph.D., Xiaoming Li Ph.D., Shan Qiao Ph.D., Zhiyong Shen, Yuejiao Zhou

Faculty Publications

Depression is one of the biggest health issues among men who have sex with men (MSM) living with HIV, where sexual identity might play an intricate role. Yet, findings of the relationship between sexual identity and depression were mixed and few studies explored its underlying mechanisms. This study aimed to examine the association between sexual identity and depression, and the potential mediating role of HIV-related stigma and moderating role of age. A cross-sectional survey was conducted among 203 MSM living with HIV in Guangxi, China. Participants provided information on sexual identity, depression, HIV-related stigma, and background information. Descriptive statistics, bivariate …

Influence Of Social Media Posts On Service Performance, Carol L. Esmark Jones, Stacie F. Waites, Jennifer Stevens

Marketing Faculty Research and Publications

Purpose

Much research regarding social media posts and relevancy has resulted in mixed findings. Furthermore, the mediating role of relevancy has not previously been examined. This paper aims to examine the correlating relationship between types of posts made by hotels and the resulting occupancy rates. Then, the mediating role of relevancy is examined and ways that posts can increase/decrease relevancy of the post to potential hotel users.

Design/methodology/approach

Within the context of the hotel industry, three studies were conducted – one including hotel occupancy data from a corporate chain – to examine the impact of social media posts on relevancy …

Crow's Nest, March 28, 2022, Crow's Nest Staff

Crow's Nest

The March 28, 2022, issue of the Crow's Nest.

Brain Electrochemistry, Cong Xu, Ying Jiang, Ping Yu, Lan-Qun Mao

Journal of Electrochemistry

Brain, as the source of neural activities such as perceptions and emotions, consists of the dynamic and complex networks of neurons that implement brain functions through electrical and chemical interactions. Therefore, analyzing and monitoring neurochemicals in living brain can greatly contribute to uncovering the molecular mechanism in both physiological and pathological processes, and to taking a further step in developing precise medical diagnosis and treatment against brain diseases. Through collaborations across disciplines, a handful of analytical tools have been proven to be befitting in neurochemical measurement, spanning the level of vesicles, cells, and living brains. Among these, electrochemical methods endowed …

Rational Design Of Electrochemical Molecular Probes For Highly Selective And Long-Term Measurement In Vivo, Yue Wang, Li-Min Zhang, Yang Tian

Journal of Electrochemistry

Designing electrochemical interfaces for in vivo analysis of neurochemicals with high selectivity and long-term stability is vital for monitoring dynamic variation and dissecting the complex mechanisms of pathogenesis in living animals. This review focuses on the development of electrochemical interfaces based on rational design of molecular probes for in vivo measurement with high selectivity and high stability from three aspects: (1) Specific recognition probes were rationally designed and created to remarkably improve the selectivity of in vivo analysis in a complicated brain environment. (2) The Au-C≡C functionalized surface was developed to remarkably enhance the stability of molecular assembly, and employed …

God's Song Of Creation, Dominic Sanfilippo

President's Blog: From the Heart

University of Dayton students took part in "a crash course on paying attention to life's intricacies and little wonders" when they traded their spring break for an unforgettable experience working with the Marianists in Ecuador.

University Of Northern Iowa Faculty Senate Meeting Minutes, March 28, 2022, University Of Northern Iowa, Faculty Senate

Documents - Faculty Senate

Meeting minutes from the Faculty Senate of the University of Northern Iowa.

The Guardian, Week Of March 28, 2022, Wright State University Student Body

The Guardian Student Newspaper

News articles from The Guardian for the week of March 28, 2022. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.

An Additive Incorporated Non-Nucleophilic Electrolyte For Stable Magnesium Ion Batteries, Mao-Ling Xie, Jun Wang, Chen-Ji Hu, Lei Zheng, Hua-Bin Kong, Yan-Bin Shen, Hong-Wei Chen, Li-Wei Chen

Journal of Electrochemistry

Non-nucleophilic electrolytes are promising next-generation highly stable electrolytes for magnesium-ion batteries (MIBs). However, a passivation layer on Mg metal anode usually blocks Mg²⁺ diffusion, leading to poor reaction kinetics and low Coulombic efficiency of the Mg plating/stripping in these electrolytes. Here we explore the utilization of phenyl disulfide (PDF) as a film-forming additive for non-nucleophilic electrolytes to regulate the interfacial chemistry on Mg metal anode. Phenyl-thiolate generated from the PDF additive was found to suppress the unfavorable surface blocking layer, resulted in a high Coulombic efficiency of up to 99.5% for the Mg plating/stripping process as well as a …

Tracking Light-Induced Fragmentation Of Single Silver Nanoparticles By Single Entity Electrochemistry, Mengjie Chen, Si-Min Lu, Hao-Wei Wang, Yi-Tao Long

Journal of Electrochemistry

Light irradiation on silver nanoparticles (Ag NPs) could cause the energy conversion, thus, the fragmentation of Ag NPs. It is important to detect the changes of fragmented Ag NPs in the aspects of physical and chemical properties. Herein, benefiting from the high sensitivity, high temporal resolution, and high-throughput, single entity electrochemistry (SEE) method is introduced to in-situ track the dynamic laser fragmentation of single Ag NP. Compared with UV-Vis absorption spectroscopy and transmission electron microscopy (TEM), SEE methods enables an accurate in-situ measurements of light-induced fragmentation of single Ag NP. The variation in the statistic current amplitude displays the real-time …

Recent Advances In Electrical Transport Spectroscopy For The In Situ Measurement Of Electrochemical Interfaces, Zhang-Yan Mu, Meng-Ning Ding

Journal of Electrochemistry

Electrochemical/electrocatalytic technology has played a central role in achieving highly efficient energy conversion and storage. To date, the in-depth electrochemical research begins to require accurate and multi-dimensional information of electrochemical interfaces, which usually relies on the application of in situ characterizations. Electrical transport spectroscopy (ETS) is a newly developed measurement strategy based on chip-platform, and provides in situ information of electrochemical interfaces from a novel perspective due to a signal origin that is fundamentally different from typical spectroscopic and electrochemical techniques. In this tutorial review, the working principle and experimental setup of ETS are described in detail with the demonstration …

The Mitigation Of In-Group And Outgroup Biases: Understanding The Perceptions Of Educators On The Contact Approach Theory, Brigitte Blazys

Dissertations

The contact approach theory was introduced in the 1950s, by Allport, as a method to mitigate biases. Since then, many DEI practitioners in the United States have formed alliances to create a social justice movement to combat racism, prejudice, and biases in our society. Nevertheless, little research has been conducted in the contact approach theory as these biases, initially observed as in-group and outgroup biases, originate in the early years of life. To begin to fill this gap in the literature, the purpose of this study was to better understand and identify to what extent, if any, prekindergarten through third …

Eating Real Mexican: Identity, Authenticity, Americanization, Health, And Food Culture In The United States After 1900, Alexandra H. Ibarra

Dissertations and Theses

This thesis examines the connection between Mexican food and identity in the early to mid-twentieth century (1900-1950). Anglo-Americans created evolving racial/ethnic stereotypes during a period of intense Mexican immigration and nativism that used descriptions of food, hygiene habits, and health to reinforce boundaries of whiteness and citizenship.

By examining Americanization teaching manuals, food articles, as well as personal and corporate cookbooks, I seek to understand how Americanizers and other food writers used food to point to emphasize, unhygienic habits, excess use of spice and grease, as well as the "questionable" nature of immigrate food culture to separate them from Anglo-Americans. …

Monospecific And Bispecific Monoclonal Sars-Cov-2 Neutralizing Antibodies That Maintain Potency Against B.1.617, Lei Peng, Yingxia Hu, Madeleine C Mankowski, Ping Ren, Rita E Chen, Michael S Diamond, Et Al

Open Access Publications

COVID-19 pathogen SARS-CoV-2 has infected hundreds of millions and caused over 5 million deaths to date. Although multiple vaccines are available, breakthrough infections occur especially by emerging variants. Effective therapeutic options such as monoclonal antibodies (mAbs) are still critical. Here, we report the development, cryo-EM structures, and functional analyses of mAbs that potently neutralize SARS-CoV-2 variants of concern. By high-throughput single cell sequencing of B cells from spike receptor binding domain (RBD) immunized animals, we identify two highly potent SARS-CoV-2 neutralizing mAb clones that have single-digit nanomolar affinity and low-picomolar avidity, and generate a bispecific antibody. Lead antibodies show strong …

Wwox Binding To The Murine Brca1-Brct Domain Regulates Timing Of Brip1 And Ctip Phospho-Protein Interactions With This Domain At Dna Double-Strand Breaks, And Repair Pathway Choice, Dongju Park, Mehdi Gharghabi, Colleen R Reczek, Rebecca Plow, Charles Yungvirt, C Marcelo Aldaz, Kay Huebner

Faculty, Staff and Student Publications

Wwox-deficient human cells show elevated homologous recombination, leading to resistance to killing by double-strand break-inducing agents. Human Wwox binds to the Brca1 981-PPLF-984 Wwox-binding motif, likely blocking the pChk2 phosphorylation site at Brca1-S988. This phosphorylation site is conserved across mammalian species; the PPLF motif is conserved in primates but not in rodents. We now show that murine Wwox does not bind Brca1 near the conserved mouse Brca1 phospho-S971 site, leaving it open for Chk2 phosphorylation and Brca1 activation. Instead, murine Wwox binds to Brca1 through its BRCT domain, where pAbraxas, pBrip1, and pCtIP, of the A, B, and C binding …

Seabem: An Artificial Intelligence Powered Web Application To Predict Cover Crop Biomass, Aime Christian Tuyishime, Andrea Basche

Honors Program: Senior Projects (Public)

SEABEM, the Stacked Ensemble Algorithms Biomass Estimator Model, is a web application with a stacked ensemble of Machine Learning (ML) algorithms running on the backend to predict cover crop biomass for locations in Sub-Saharan. The SEABEM model was developed using a previously developed database of crop growth and yield that included site characteristics such as latitude, longitude, soil texture (sand, silt, and clay percentages), temperature, and precipitation. The goal of SEABEM is to provide global farmers, mainly small-scale African farmers, the knowledge they need before practicing and benefiting from cover crops while avoiding the expensive and time-consuming operations that come …