Digital Commons Network^™

A Benzodiazepine Activator Locks K V 7.1 Channels Open By Electro-Mechanical Uncoupling, Julian A Schreiber, Melina Möller, Mark Zaydman, Lu Zhao, Zachary Beller, Sebastian Becker, Nadine Ritter, Panpan Hou, Jingyi Shi, Jon Silva, Eva Wrobel, Nathalie Strutz-Seebohm, Niels Decher, Nicole Schmitt, Sven G Meuth, Martina Düfer, Bernhard Wünsch, Jianmin Cui, Guiscard Seebohm

Open Access Publications

Loss-of-function mutations in K

Molecular Dissection Of Rbpa-Mediated Regulation Of Fidaxomicin Sensitivity In Mycobacteria, Jerome Prusa, Dennis X Zhu, Aidan J Flynn, Drake Jensen, Ana Ruiz Manzano, Eric A Galburt, Christina L Stallings

Open Access Publications

RNA polymerase (RNAP) binding protein A (RbpA) is essential for mycobacterial viability and regulates transcription initiation by increasing the stability of the RNAP-promoter open complex (RP

Failed Targeted Muscle Reinnervation: Findings At Revision Surgery And Concepts For Success, John M Felder, Stahs Pripotnev, Ivica Ducic, Rachel Skladman, Austin Y Ha, Mitchell A Pet

Open Access Publications

Although it was initially described for improved myoelectric control, targeted muscle reinnervation (TMR) has quickly gained popularity as a technique for neuroma control. With this rapid increase in utilization has come broadening indications and variability in the described technique. As a result, it becomes difficult to interpret published outcomes. Furthermore, there is no literature discussing the management of failed cases which are undoubtedly occurring.

Methods: This is a retrospective case series of two patients who underwent revision surgery for failed TMR. The authors also review the current literature on TMR and outline technical and conceptual pitfalls and pearls based on …

Global Variation In Studies Of Articular Cartilage Procedures Of The Knee: A Systematic Review, R. Garrett Steinmetz, J. Jared Guth, Matthew J Matava, Matthew V Smith, Robert H Brophy

Open Access Publications

OBJECTIVE: The objective of this study was to determine whether there are significant differences in terms of indications, techniques, patient variables, and objective and subjective outcome scores as a function of the geographic locale of published studies of knee articular cartilage surgery.

METHODS: An electronic database search was performed of clinical studies evaluating knee articular cartilage procedures from 2000 to 2021. Studies were separated into global regions (Europe, Asia, North America, and South America) based on the study country. All cartilage-based treatments in each region were recorded. Patient age and sex, mechanism of injury, cartilage lesion size and location, follow-up …

Exploring The Bedrock For Earth Jurisprudence, Maria Antonia Tigre

Sabin Center for Climate Change Law

This article calls for a reassessment of our core beliefs on how we relate to the environment through a deep dive into the philosophical foundations of environmental protection. With this purpose, it shows how Earth-centered discourses have existed in human societies and civilizations for millennia. Different religious and philosophical underpinnings all share a view of humanity as an integral part of an organic whole, revering all living things. While recent developments in jurisprudence may appear novel, they are somewhat latent and emergent. Theories of land ethics, rights of nature, Earth-centered environmental ethics, wild law, and Earth jurisprudence all build on …

Targeting Calcium-Mediated Inter-Organellar Crosstalk In Cardiac Diseases, Mohit M Hulsurkar, Satadru K Lahiri, Jason Karch, Meng C Wang, Xander H T Wehrens

Faculty, Staff and Students Publications

INTRODUCTION: Abnormal calcium signaling between organelles such as the sarcoplasmic reticulum (SR), mitochondria and lysosomes is a key feature of heart diseases. Calcium serves as a secondary messenger mediating inter-organellar crosstalk, essential for maintaining the cardiomyocyte function.

AREAS COVERED: This article examines the available literature related to calcium channels and transporters involved in inter-organellar calcium signaling. The SR calcium-release channels ryanodine receptor type-2 (RyR2) and inositol 1,4,5-trisphosphate receptor (IP

EXPERT OPINION: Enhanced SR calcium release via RyR2 and reduced SR reuptake via SERCA2a, increased VDAC and MCUC-mediated calcium uptake into mitochondria, and enhanced lysosomal calcium-release via lysosomal TPC and TRPML …

Colonic Epithelial Angiotensin-Converting Enzyme 2 (Ace2) Expression In Blacks And Whites: Potential Implications For Pathogenesis Covid-19 Racial Disparities, Mart De La Cruz, David P Nunes, Vaishali Bhardwaj, Deepika Subramanyan, Caroline Zaworski, Priya Roy, Hemant K Roy

Faculty, Staff and Students Publications

BACKGROUND: Covid-19 toll is disproportionate in Blacks although the mechanisms remain incompletely understood. From a biological perspective, several host proteins have received most attention as logical susceptibility targets. Specifically, angiotensin-converting enzyme 2 (ACE2) serves as the epithelial cell receptor and acts in concert with transmembrane protease serine 2 (TMPRSS2). Intriguingly, ACE2 can also suppress the inflammatory response and therefore may impact the severity of Covid-19 infections (from the exuberant immune response a.k.a. "cytokine storm"). We, therefore, assessed expression of ACE2 and TMPRSS2 in Blacks versus Whites.

METHODS: Archived mucosal biopsies from colonoscopic biopsies of visually normal rectal mucosa without concurrent …

Severe Asthma In Children: An Official Statement From Saudi Pediatric Pulmonology Association, Adel S. Alharbi, Abdullah A. Yousef, Saleh A. Alharbi, Talal M. Almaghamsi, Faisal M. Al-Somali, Turki S. Alahmadi, Sami A. Alhaider, Wadha H. Alotaibi, Mona A. Albalawi, Faisal N. Alotaibi, Ahmed S. Alenizi, Muslim M. Alsaadi, Yazan S. Said

Saudi Medical Journal

In Saudi Arabia, the prevalence of pediatric asthma ranges between 8% and 25%. However, there are no sufficient data regarding severe asthma in childhood in Saudi Arabia. Therefore, a task force has been formed by the Saudi Pediatric Pulmonology Association which is a subsidiary group of the Saudi Thoracic Society and consists of Saudi experts with well-respected academic and clinical backgrounds in the fields of pediatric asthma as well as other respiratory diseases to write a consensus on definitions, phenotypes, and pathophysiology, evaluation, and management. To achieve this, the subject was divided into various sections, each of which was assigned …

Evaluation Of The Effects Of Berberine In The Prevention Of Epidural Fibrosis In Rats: An Experimental Research, Emrah Keskin, Çağhan Tönge, Mustafa Kaya, Emre Işık

Saudi Medical Journal

Objectives: To evaluate the effect of berberine (BBR) in preventing the development of epidural fibrosis (EF) after lumbar surgery in rats. Methods: This experimental study was carried out at the animal laboratory of Zonguldak Bülent Ecevit University, Zonguldak, Trurkey, between April 2020 and June 2020. A total of 32 Wistar albino female rats underwent laminectomy and were divided into 4 equal groups. Group 1 did not receive any treatment (control group). In group 2, absorbable gelatin sponge was placed at the surgical site. Groups 3 was administered BBR 10 mg/kg and group 4 was administered BBR 60 mg/kg per oral …

The Effect Of Fetal Gender On The Biochemical Markers Of The First-Trimester Screening, Hakan Cokmez, Simge Tezel Yozgat

Saudi Medical Journal

Objectives: To determine the effects of fetal gender on the maternal levels of first-trimester screening biochemical markers, such pregnancy-related plasma protein A (PAPP-A) and beta-human chorionic gonadotropin (β-hCG). Methods: In this retrospective study, we assessed 267 cases of singleton pregnancies, who underwent first trimester screening tests and delivered between January 2016 and January 2019 at our hospital. Multiple of median (MoM) levels of PAPP-A and free β-hCG, and the neonatal genders according to the birth records were compared and analyzed. Additionally, patients with small for gestational age (SGA) newborns, preeclampsia, and placental ablation, called ischemic placental diseases, were classified into …

Environment-Driven Shifts In Inter-Individual Variation And Phenotypic Integration Within Subnetworks Of The Mussel Transcriptome And Proteome, Richelle L. Tanner, Lani U. Gleason, W. Wesley Dowd

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The environment can alter the magnitude of phenotypic variation among individuals, potentially influencing evolutionary trajectories. However, environmental influences on variation are complex and remain understudied. Populations in heterogeneous environments might exhibit more variation, the amount of variation could differ between benign and stressful conditions, and/or variation might manifest in different ways among stages of the gene-to-protein expression cascade or among physiological functions. Here, we explore these three issues by quantifying patterns of inter-individual variation in both transcript and protein expression levels among California mussels, Mytilus californianus Conrad. Mussels were exposed to five ecologically relevant treatments that varied in the mean …

Spatial Sequestration Of Misfolded Proteins In Neurodegenerative Diseases, Sarah Rolli, Emily M. Sontag

Biological Sciences Faculty Research and Publications

Properly folded, functional proteins are essential for cell health. Cells sustain protein homeostasis, or proteostasis, via protein quality control (PQC) mechanisms. It is currently hypothesized that a breakdown in proteostasis during ageing leads to the accumulation of protein aggregates in the cell and disease. Sequestration of misfolded proteins into PQC compartments represents one branch of the PQC network. In neurodegenerative diseases, certain proteins form abnormal protein deposits. Which PQC compartments house misfolded proteins associated with neurodegenerative diseases is still being investigated. It remains unclear if sequestration of these misfolded proteins is toxic or protective to the cell. Here, we review …

Leadership Influence: Adoption Professional, Birth Mother, And Adoptive Parents’ Knowledge Of Open Adoption, Vicki K. Colls

Doctoral Dissertations and Projects

Adoption needs a minimum of three sets of participants: the birth mother, the adoptive parents, and the adoptive professionals. Being the adoption expert, the adoption professional leads all parties through the process of adoption. However, as adoption research grows, it focuses on the adoptee, birth mother, and adoptive parents but rarely on the adoption professional. As the central figure in the adoption process, the assumption is the adoption professional would be the primary influencer affecting the culture of adoption practices. The purpose of this quantitative descriptive, correlational study was to evaluate if a relationship exists between the adoptive professional's leadership …

A Phenomenological Study On The Experiences And Needs Of Disabled Students In Higher Education, Alanka Babb

Doctoral Dissertations and Projects

The purpose of this phenomenological study was aimed to describe the experiences of twelve students with disabilities at a higher education institution in Maryland. The theory that guided this study was Luigi Taparelli d’Azeglio’s (1843) and John Rawls’s social justice theory. The social justice theory addresses the importance of equality, access, liberty, and the fair distribution of resources in society to promote social and economic development for all. A qualitative methodology was used to execute the study. Data was collected using focus groups, interviews, and letters. The data was analyzed using Moustaka’s (1994) modification of Van Kaam’s method of phenomenological …

A Phenomenological Study Examining The Experiences Of Single Parents Who Are Rearing Elementary-Aged Children Enrolled In A Public School In A Rural Community, Jenine Lavonne Cotman

Doctoral Dissertations and Projects

Abstract The purpose of this qualitative transcendental phenomenological study was to examine the experiences of single parents who are rearing elementary-aged children enrolled in a public school in a rural community. Vygotsky’s sociocultural theory of cognitive development was used to guide this study. Vygotsky’s theory focuses on cognitive development being fundamentally framed by social interaction. Vygotsky also believed that cognitive development is strengthened when a child is encouraged to learn within their zone of proximal development, which refers to a person’s current cognitive space that can be further developed with social interaction and help from a teacher, peer, or parent. …

How Christian Teachers Perceive Their Engagement Facilitates Spiritual Formation Within At-Risk Male Students: A Case Study, Stephanie Eldridge

Doctoral Dissertations and Projects

The purpose of this qualitative intrinsic case study was to understand the experiences of teacher’s perception of their engagement to facilitate spiritual formation within at-risk students at Southeast Christian Alternative School (pseudonym). This participating school is recognized by the North Carolina Department of Administration as a non-public school. The program uses a Wilderness Therapeutic approach to learning. Four essential elements were explored. Teacher’s engagement concerning behavior management was assessed through processes that tactically managed disorderly conduct or acts of misbehavior. Implementation of any behavior plans or behavior models were applicable. Teacher’s engagement concerning spirituality was assessed through active practices of …

Act Score And Sub Score As Predictors Of Pass/Fail On The Credentialing For Registered Dietitian Nutritionist, Jeanna Marie Haggard

Doctoral Dissertations and Projects

The profession of nutrition and dietetics is currently experiencing a significant change in the educational process with the conversion to a competency based graduate program for the process of licensure and ability to practice in the profession. In addition, the overall pass rate has declined nationwide, thus creating the need for accurate academic predictors for passing. For many health science programs, standardized exams continue to be an effective predictor of passing licensure exams. With many of the institutions of higher education dropping the requirement for test scores as part of the admission process, this is a consideration for many programs …

Differences Of Attitudes And Norms Toward Plagiarism Between First- And Continuing-Generation College Students, Michael Owen Harris

Doctoral Dissertations and Projects

This quantitative, causal-comparative study examines differences in attitudes and subjective norms between first- and continuing-generation college students toward plagiarism. Research studies have reported that up to 90% of college students admitted having committed plagiarism. Plagiarism harms the student who cheats, the reputation of the school, and all associated. First-generation college students experience greater challenges in their first years of college than their continuing-generation peers and may be more at risk for resorting to plagiarism. The researcher employed the Attitude Toward Plagiarism Questionnaire (Cronbach’s score of .79) to measure attitudes and norms toward plagiarism. The findings from the administration form the …

Childhood Trauma: Nobody Told Me It Would Impact My Marriage Too, Charles Matthew Houston

Doctoral Dissertations and Projects

This thesis project addressed the couple’s ministry life group class at Ridgeville Church of God, as it intends to address how childhood trauma affects married couples. The purpose was to provide proper tools and resources through an education process such as a marriage conference. Chapter One introduces the church’s historical context, mission statement, vision statement, the possible limitations of implementing such a class, and the pastor’s professional background. The literature review in Chapter Two highlights the powerful effects of childhood trauma, especially in individuals’ marriages, more specifically, couples’ intimacy. Survey-style data was the selected method used in this research due …

A Phenomenological Study Of The Student Engagement Experiences Of African Americans Formerly Attending Urban Public High Schools, Sohn A. Butts

Doctoral Dissertations and Projects

The purpose of this hermeneutic phenomenological study was to interpret the student engagement experiences of African Americans formerly attending urban public high schools in a major city in the Mid-Atlantic region of the United States. Self-determination theory, established by Ryan and Deci (1985), is the theoretical framework for this study, and was used to understand motivation in terms of basic psychological needs satisfaction and fulfillment, and how those motivations influence human behavior. The central research question was: What were the student engagement experiences of African Americans formerly attending urban public high schools? The three research sub-questions were: (1) what instructional …

Evaluation Of The Effectiveness Of Non-Pharmacological Pain Interventions On Patient Reported Pain Scores And Opioid Use In Hospitalized Adult Patients, Tammy Jane Anderson

Doctoral Dissertations and Projects

The purpose of this integrative review is to research, critique, and synthesize current literature to ascertain the effectiveness of nonpharmacological pain management interventions on hospitalized patient reported pain scores and the use of opioids. Patients report pain while hospitalized for a variety of reasons. In order to become an active participant in their recovery, patients must have their pain adequately controlled. The use of opioids for main management may be required but alternatives exist. These alternatives do not have the same risk factors as opioid pain management. Nonpharmacological interventions included music, virtual reality, massage, guided imagery/hypnosis, and psychological interventions. All …

From Mocker To Martyr: The Unlikely Conversion Of James The Brother Of Jesus, Brian Lewis Cunningham

Doctoral Dissertations and Projects

For many years, James, the brother of Jesus, was all but neglected when it came to biblical scholarship. Around four decades ago, there was a resurgence of serious inquiry about James. Since that time, a considerable amount of scholarly material has been published about him, including a possible connection between James and a first-century ossuary box that bears his name. But one aspect of James’s life has not enjoyed such widespread discussion, namely, his conversion. The reason his conversion has been ignored is because there is so little prominent information. The only glimpse afforded to us comes from Jesus appearing …

The Decline Of Youth At Ministry Under The Sky, Wanda Elaine Belvin

Doctoral Dissertations and Projects

The decline of youth attending their services is no secret for many churches. The influences of the world, technology, wanting to fit in are just a few reasons youth find other things to do than attend their church services faithfully. Ministry Under The Sky is a small ministry with a big heart. At its birth in 2001, Ministry Under The Sky’s start was in the researcher’s home and her husband, the Overseer of the ministry. God blessed Ministry Under The Sky with its first building in 2007. The church outgrew the first two buildings less than two years each. The …

Prevalence And Correlates Of Food And Housing Insecurities At A Historically Black College, Melissa Massey Lockard

Doctoral Dissertations and Projects

The purpose of this quantitative, predictive correlational study was to determine the prevalence of food and housing insecurities at one historically Black college and explore whether these insecurities influence students’ academic performance or their mental health quality. The study also explored possible predictors of students at risk of experiencing these basic needs challenges. A convenience sample of 175 participant surveys was collected in the fall 2021 semester at the small, private, liberal arts college in urban South Carolina. The instruments used in the survey included the USDA’s 6-item Household Food Security Survey Module, the Housing Insecurity and Homelessness Module, the …

Benefits Of Mental Illness Training Programs In The Church, Blessed Onaiwu

Doctoral Dissertations and Projects

The church consists of God’s people. It is the assembly of believers in Jesus Christ. The physical buildings facilitate the fellowship, worship, and ministry of God’s people. According to Matthew 10:8, one of the mandates given to the body of Christ is to heal the sick. Mental illness of any form is an illness that requires proper care and attention. And we know Jesus came to comfort us in all our afflictions which include mental illness; most churches do not address this topic due to stigma. There is often a greater shame regarding this illness within the church than outside, …

Lived Experiences Of Parents And Professionals With Technology And Emotional Dysregulation In Children, Ages 3-5-Years-Old: A Phenomenological Study, Angela P. Rathkamp

Doctoral Dissertations and Projects

Digital devices have become more extensively used and have created a dramatic shift in how children, adolescents, and families use this technology. Excessive screen time has been associated with increased behavioral health problems, sleep disturbances, anxiety, depression, and decreased family functioning. The relationship between problematic technology use and emotional dysregulation in young children is just emerging, therefore leaving a gap in research literature. The purpose of this study was to explore the lived experiences of parents and professionals with technology and emotional dysregulation in children ages 3-5-years-old and to identify emotional characteristics specific to technology and emotional dysregulation. It further …

An Investigation Of The Impacts Of Locus Of Control On Marital Satisfaction Among Wives Of Combat Veterans With Ptsd In The U.S., Rachel Sims

Doctoral Dissertations and Projects

Posttraumatic stress disorder (PTSD) is a significant cause of marital instability and divorce among PTSD veterans, which researchers have cited in the field of psychological disorders. The current study investigated the psychological structure of how marital satisfaction was related to the locus of control among wives of veterans with PTSD diagnosis. No prior studies have explored this relationship, as shown from an extensive search in current literature. The study compared the reported marital satisfaction of women with the locus of control to fill this gap. The family systems theory was applied to guide this research study. In addition, the study …

Examining The Correlation Between Childhood Trauma And Suicidal Ideation Among Air Force Airmen, Jennifer L. Thomas

Doctoral Dissertations and Projects

For decades, the United States military has been concerned about high suicide rates. Due to the increasing suicide rate within the armed forces, the need to better understand suicide-associated factors such as childhood trauma exposure is imperative. It is important to identify the research gaps that exist for promoting understanding of suicide and suicidal behavior and to enhance identification of those at risk for suicide. While there have been many published studies on the topic, conspicuously absent are studies that have included U.S. Air Force personnel. This research will examine the correlation between childhood trauma and suicidal ideation among Air …

The Significance Of Trauma In The Relationship Between Co-Occurring Disorders And Recidivism Among Participants Of A Community Mental Health's Jail Diversion Program, Emily A. Schott

Doctoral Dissertations and Projects

Abstract Individuals with a psychiatric diagnosis have higher levels of criminal justice involvement compared to the general population. Multiple programs have been developed through grant monies utilizing various models to allow these individuals to be linked to mental health services in the community for the treatment of symptoms which may contribute to recidivism. These programs are designed to provide an encounter with mental health professionals who collaborate with law enforcement and other agencies to intercept these individuals at various points of justice involvement and possibly prevent further entanglements with the legal system. This study explores how trauma may impact justice …

The Difference Between Grade 7 Female And Male Test Scores Based On One-To-One Technology Access: A Causal-Comparative Study, Windy Simonne Hammond

Doctoral Dissertations and Projects

This causal-comparative study sought to determine whether there was a relationship between the use of one-to-one technology and student achievement among female and male students in Grades 6 and 7 in public schools in South Carolina. This study adds to the body of literature that indicates academic gains occur from using one-to-one devices in classrooms and that these didactic technology tools are beneficial to all students. The current study analyzed the science and social studies achievement scores of 3,747 Grade 7 students, comparing females and males who had access to one-to-one technology to those who did not during the 2016–2017 …