Digital Commons Network^™

Providing Culturally Competent Eldercare For Asian Americans, Britney Ngo

Honors Theses

As the Asian American elderly population continues to grow, it is important to acknowledge cultural factors that may impact their behavior, attitudes, preferences, and decisions in the context of eldercare. Cultural competency acknowledges and considers these factors while providing care that includes biophysical factors of healthcare as well as non-medical dimensions of care such as language and culture.

This thesis seeks to address the applications of providing culturally competent eldercare to Asian Americans and offer future recommendations to care settings that have limited resources by utilizing a multidisciplinary review of literature accompanied by interviews with representatives from On Lok, a …

Peak Forces And Force Generating Capacities Of Lower Extremity Muscles During Dynamic Tasks In People With And Without Chronic Ankle Instability, Hoon Kim, Riann M. Palmieri-Smith

Exercise Science Faculty Research and Publications

People with chronic ankle instability (CAI) exhibit neuromuscular deficits. However, no study has investigated deficits in forces or force-generating capacities of individual muscles in people with CAI during dynamic tasks. Therefore, the purpose of this study was to estimate and compare peak forces and force-generating capacities of individual muscles during dynamic tasks in people with CAI and healthy controls (CON). Eleven people with CAI and eleven CON performed landing, anticipated cutting, and unanticipated cutting as motion capture, force plate, and electromyography data were recorded. A musculoskeletal model was used to estimate the force and force-generating capacity of lower extremity muscles. …

Active Leisure And Ageing In Rural Ireland: Exploring Perceptions And Motivations To Facilitate And Promote Meaningful Physical Activity, Angie Hartnett, Catherine Gorman

Articles

The life expectancy of the world population is increasing and the art of aging well is of global interest (European Commission, n.d.). In Ireland, the number of people over the age of 60 will increase from 1.1 million currently, to 2.44 million by 2041, constituting nearly one third of its total population (Institute of Public Health, 2018). Despite the benefits of regular physical activity (pa), particularly with the frail (≥65 years and requiring a walking aid), rates of participation remain low (Colley et al., 2011). Health concerns raised, such as smoking and weight issues, are more prevalent in this cohort …

Is Breast Conservation Superior To Mastectomy In Early Stage Triple Negative Breast Cancer?, Joseph Panoff

All Publications

Purpose: Compare overall survival (OS) and breast cancer-specific survival (BCSS) outcomes of breast conservative therapy (BCT) and mastectomy in a large cohort of patients with early-stage triple negative breast cancer (TNBC), using a propensity score-based matching approach.

Methods: Surveillance, Epidemiology, and End Results (SEER) database was used to study the role of RT in early stage TNBC. Primary end points were OS and BCSS. Cox proportional hazard regression models and Kaplan-Meier plots were used to generate the desired outcomes. Propensity score matching was done to minimize bias.

Results: 12,761 patients with T1-2N0M0 TNBC as their first malignancy were retrieved. Of …

Mitophagy-Mediated Regulation Of Ros Homeostasis During Hsc Activation Contributes To Cell Fate, Amber Lynne Smith

Theses and Dissertations (ETD)

The ability of hematopoietic stem cells to self-renew and differentiate is required for the maintenance of all blood lineages under basal physiologic conditions and in response to inflammatory stress. The degradative capacity of the autophagy-lysosomal system is a determinant of hematopoietic stem cell (HSC) activation status with low autophagy predicting activation of HSCs, and autophagy deficiency causing the spontaneous loss of quiescence and HSC exhaustion. Although an increase in mitochondrial activity has been suggested as the cause of HSC depletion in autophagy-defective models, the contribution of mitophagy to HSC function remains to be elucidated. Here, we capitalized on the observation …

Cellular Dynamics And Disease Outcome Of Type 3 Streptococcus Pneumoniae Clinical Isolates Differ Between Strains, Taylor Rae Plunkett White

Theses and Dissertations (ETD)

Streptococcus pneumoniae is a bacterial pathogen that continues to be a major cause of disease around the world. It is not only the number one cause of bacterial pneumonia but also the cause of about 15% of the deaths of children under 5 around the world. There is a lot of research done on this organism, but with around 100 known serotypes and each one producing a unique capsule, there is still much more to be studied. The Etiology of Pneumonia in the Community (EPIC) study conducted by the CDC observed the burden of hospitalizations caused by pneumonia while determining …

A Rodent Animal Model For Forelimb To Lower Jaw Reorganization In Primary Somatosensory Cortex (Si) Barrel Field, Violeta Pellicer Morata

Theses and Dissertations (ETD)

The goal of this study is to examine mechanisms underlying cortical reorganization in rat primary somatosensory (SI) cortex that follows forelimb deafferentation. The majority of human patients suffering from limb loss or brachial plexus avulsion injury, as well as patients that receive brachial plexus anesthesia, report phantom limb sensations/pain which are often associated with cortical reorganization. Patients with upper-limb deafferentation report sensations of the missing hand during tactile stimulation of the face, and this phenomenon has been termed hand-to-face remapping. We sought to develop a rodent model of deafferentation; our model system is the rat SI cortex barrel field present …

Targeting Protein Degradation To Uncover Novel Oncoprotein Drivers Of Acute Leukemia, Fatemeh Keramatnia

Theses and Dissertations (ETD)

Acute Lymphoblastic Leukemia (ALL), the most common childhood cancer and the second most common acute leukemia in adults, arises from clonal expansion of undifferentiated lymphoid precursor cells in bone marrow. Despite the extensive knowledge on its cytogenetic and molecular biology, ALL treatment remains highly challenging especially after relapse. Conventional chemotherapy has shown significant improvement in overall survival rates of pediatric patients up to 90%, however, treatment failure due to ALL relapse occurs in 15-20% of the cases. On the other hand, adults and elderly patients with ALL are considered difficult to treat populations with the 5-year overall survival of 30–40%. …

The Relationship Of Child Health And Parenting Stress To Child Neurocognitive Development, Nancy Alise Farrell

Theses and Dissertations (ETD)

Problem. Although the United States rates high in economic resources, the neurocognitive development (NCD) of children falls behind many other developed nations. Levels of parenting stress may be linked to sociodemographic factors such as the high incidence of poverty in children or health disparities in children, which in turn may affect NCD in children. Using the data from an observational, longitudinal cohort study of a diverse population could provide information related to parenting stress, child health, and related factors to guide and support interventions with families and policies to improve child NCD. Aims. The overall aim of this study was …

Immunomodulatory Roles Of The Lysosomal Sialidase Neuraminidase 1, Leigh Ellen Fremuth

Theses and Dissertations (ETD)

Background Sialic acids are key sugar moieties located at the non-reducing terminals of glycan chains on glycoproteins and glycolipids. By virtue of their location, they influence the functions and biochemical properties of the macromolecules they are bound to. Removal of sialic acids in mammalian cells is carried out by four sialidases, which are differentially expressed and localized in distinct subcellular compartments. Neuraminidase 1 (NEU1), the most abundant and ubiquitous of the four sialidases, functions primarily in the acidic environment of the lysosomes, but can hydrolyze substrates at the plasma membrane, at least in certain cell types. The enzyme initiates the …

Developing Targeted Therapies For T-Cell Acute Lymphoblastic Leukemia, Jianzhong Hu

Theses and Dissertations (ETD)

Introduction Acute lymphoblastic leukemia (ALL) is the most common cancer in children, and risk-adapted chemotherapies have dramatically improved the outcomes of this disease. Compared to B-cell ALL, T-cell ALL (T-ALL) is more aggressive and has worse outcomes from chemotherapy. There is a great unmet need to develop biomarkers and novel targeted therapies for this type of cancer. Working together with internal and external collaborators, we performed a large-scale pharmacotyping assay in over 300 primary ALL samples. By combining pharmacotypying and genomic profiling of these samples, we identified a substantial T-ALL population that showed strong response to dasatinib, a known ABL1 …

Substituent Effect Analysis Of The Synthesis Of 1-Azabicyclo[2.2.1]Heptan-2-One Using Diels-Alder Reactions, Vida Robertson

Honors Theses

No abstract provided.

Cna Status As An Admission Criterion For Undergraduate Nursing Students: A Comparative Case Study, Nancy Capponi

Dissertations

Undergraduate nursing programs continue to be unable to meet the current and projected demand for nurses. Faculty and administrators need to choose admission criteria that best predict student success in the program to provide newly graduated nurses to meet societal demands for nurses. The objective for this study was to investigate the perceptions of clinical faculty and undergraduate nursing students regarding effects of the nonacademic admission criterion of status as a Certified Nursing Assistant (CNA) on first-year student preparedness for the clinical setting, self-confidence and anxiety in clinical decision-making (CDM), and student success. A comparative case study design was used …

On The Thermodynamics Of Self-Organization In Dissipative Systems: Reflections On The Unification Of Physics And Biology, Bong Jae Chung, Benjamin De Bari, James Dixon, Dilip Kondepudi, Joseph Pateras, Ashwin Vaidya

Department of Mathematics Faculty Scholarship and Creative Works

In this paper, we discuss some well-known experimental observations on self-organization in dissipative systems. The examples range from pure fluid flow, pattern selection in fluid–solid systems to chemical-reaction-induced flocking and aggregation in fluid systems. In each case, self-organization can be seen to be a function of a persistent internal gradient. One goal of this article is to hint at a common theory to explain such phenomena, which often takes the form of the extremum of some thermodynamic quantity, for instance the rate of entropy production. Such variational theories are not new; they have been in existence for decades and gained …

Impacts Of Land-Use Change And Urban Development On Carbon Sequestration In Tropical Seagrass Meadow Sediments, Martin Dahl, Rashid Ismail, Sara Braun, Pere Masqué, Paul S. Lavery, Martin Gullström, Ariane Arias-Ortiz, Maria E. Asplund, Andrius Garbaras, Liberatus D. Lyimo, Matern S.P. Mtolera, Oscar Serrano, Chanelle Webster, Mats Björk

Research outputs 2022 to 2026

Seagrass meadows store significant carbon stocks at a global scale, but land-use change and other anthropogenic activities can alter the natural process of organic carbon (Corg) accumulation. Here, we assessed the carbon accumulation history of two seagrass meadows in Zanzibar (Tanzania) that have experienced different degrees of disturbance. The meadow at Stone Town has been highly exposed to urban development during the 20th century, while the Mbweni meadow is located in an area with relatively low impacts but historical clearing of adjacent mangroves. The results showed that the two sites had similar sedimentary Corg accumulation rates (22–25 g m−2 yr−1) …

Paratesticular Solitary Fibrous Tumour Mimicking Cellular Angiofibroma: An Unusual Morphology And Rare Site, Madiha Bilal Qureshi, Muhammad Usman, Qurratulain Chundriger, Nasir Uddin

Department of Pathology and Laboratory Medicine

Solitary fibrous tumour (SFT) is a ubiquitous benign mesenchymal tumour of fibroblastic origin, which occurs most often in middle-aged adults. It usually presents as lung mass originating from pleura, but extrapleural occurrence is also common. Tumour is characterised by hypo- and hyper-cellular areas of spindle-shaped cells, arranged in haphazard manner with dispersed staghorn-shaped vessels. Surgical excision is the curative treatment. SFTs of the primary testicular or paratesticular region are extremely rare, but they exhibit histologic findings similar to SFTs originating at other body sites. Here, we report the case of a paratesticular SFT in a 37-year male, who presented with …

Building For The Future: Functional, Energy-Efficient, And Beautiful Buildings By Snøhetta, Amanda J. Oross

Student Publications

The construction industry accounts for nearly 40% of all greenhouse gas emissions, which ultimately leads to climate change. Because of a lack of global consensus and accountability on a large scale about how to combat climate change, certain countries and cities are leading the charge on mitigation, since they tend to be more progressive and homogenous. Norway is one of those countries, and happens to be the headquarters for Snøhetta, a design company, that is designing buildings that are not only energy-efficient but also functional for the space in which it resides. Snøhetta very much values the interconnection between the …

Evaluating Human Pressure On Protected Areas In East Africa, Bailey M. Ytterdahl

Student Publications

Protected areas (PAs) are crucial to achieving effective conservation goals and mitigate the loss of biodiversity. I investigated the following research questions: How does human pressure threaten PAs in East Africa? Is human pressure associated with the factors of country, ecosystem characteristics, size, or governance type of a PA? For this study, I used a combination of a GIS analysis and case studies to evaluate human pressure on PAs in Tanzania and Kenya. For the GIS analysis, I used 589 terrestrial PAs from the World Database on Protected Areas (WDPA). Within each PA, I summarized the landform, landcover, moisture level, …

Ecosystem Service Trade-Offs In Coral Reefs: A Global Analysis, Megan E. Keene

Student Publications

Coral reefs are biodiversity hotspots that provide humans with extractive ecosystem services like fisheries and non-extractive services like tourism. Though no studies have examined these trade-offs among these services at a global scale, there are now large, open datasets that make this possible. Using these datasets, we asked whether spatial protection and the level of protection (World Database on Protected Areas) impacted coral reef tourism value (Atlas of Ocean Wealth). We also examined whether proximity to regions of high fishing effort, defined as the top 25th percentile of the average annual effort from Global Fishing Watch, impacted tourism values. Since …

The Maximal Reconstruction Of Chen Zi-Ang’S Physical Appearance From The Perspective Of Psychology, With A Discourse On Those Of Chen Yuan-Jing, Wu Zetian, And Madam Gao (從心理學角度，最大限度重構陳子昂形貌；兼議陳元敬、武則天、高氏形貌), Xiao-Yu Chen

Student Publications

Chen Zi-Ang was a young man who had long black hair and black eyes. When appearing in public, as long as he had the conditions to do so, he bound his long, black hair in the common hairstyles among his contemporary Chinese men. Nevertheless, when in situations such as resting in his bed because of his long-term illness, his long, black hair was often untied. For a long time, Chen was very thin, and he had suffered from long-term physical illness. Chen's physical appearance further included most if not all of these characteristics: a light skin color, a comparatively soft …

Integrating Objectification And Social Role Theories: A Proposed Framework For Analyzing Media Objectification Of Female Athletes, Isabella Clemens

Student Publications

Despite the tremendous strides that women have taken in terms of their participation in sports the representation they receive from the media is still lacking. In addition, when they do receive media attention research has found that female professional athletes are more likely to be seen and focused on their appearance rather than their success and capabilities. This is a trend that has been persistent in the sports world. This paper will provide a review of the research by looking at two theories, the objectivation theory, and the social role theory. These theories have helped explain the inequalities that women …

Brown Fat In Humans: The Significance Of Thermogenic Active Tissue, Brett T. Swanson

Student Publications

Brown adipose tissue is a metabolically active form of fat in the body that performs a crucial function in non-shivering thermogenesis. It can be compared to the prevalent white adipose tissue which is generally understood to be energy storage in the body, with brown tissue performing an opposing role. The tissue itself contains unique gene and protein markers such as uncoupling protein 1 (UCP1) which allows for the thermogenic process inside the cell, burning lipids to do so. These gene and protein markers have proven to be crucial in the detection of brown adipose tissue, which had previously been thought …

Brown Adipose Tissue (Bat) Activation And Its Potential Utilization As A Treatment Option For Obesity And Diabetes, Darcie B. Schneider

Student Publications

Within the human body, there are two types of adipose tissue: white adipose tissue (WAT) and brown adipose tissue (BAT). WAT is beneficial for insulation whereas BAT has thermogenic capacity. BAT activation increases energy consumption via heat generation. Increased energy expenditure is associated with improved glucose and lipid metabolism. Therefore, BAT activation research has primarily been aimed at its potential use in the treatment of obesity, diabetes, and other metabolic disorders. In this literature review, BAT's thermogenic mechanisms, techniques of activation, potential therapeutic targets, and future research topics are explored.

Estimating Fish Diet In Lake Turkana, Kenya, Julia G. Sharapi

Student Publications

Lake Turkana, located in northern Kenya on the Ethiopian border, is the world’s largest permanent desert lake. Over 90% of its flow originates from the Omo River in Ethiopia, which causes the lake to have seasonal rises and falls in water level. The Omo River has been subject to the construction of five dams (the Gilgel Gibe dams) and several irrigation projects. These developments will impact the amount of water entering the lake, with implications for lake chemistry and productivity, littoral habitat availability, and the breeding biology of the lake’s fishes. Though ongoing upstream changes are likely to have serious …

Logging Impacts On Aquatic Ecosystem Quality In Michaux State Forest, Pennsylvania, Sara Baran, Timothy J. Bell, Erick R. Seager

Student Publications

Logging can affect freshwater streams around logging sites, even years after the logging has occurred. In this study, we looked into how sustainable logging in Michaux State Forest (in Adams County, Pennsylvania) has affected two streams within the state park: Mountain Creek and Birch Run. Six sites were selected along each stream, with three upstream and three downstream from the logging area. We hypothesized that the water quality would be lower at the stream sites downstream from the logged areas as compared to the upstream sites. At each site, water samples were collected, including pH, water temperature, and turbidity, as …

Extreme Exposure To Cold: A Method To Enhance Physical Wellness And Recovery, Mallory E. Duggan

Student Publications

This paper reviews the current literature on Cryotherapy and its ability to enhance physical wellness and recovery. The paper details the proposed mechanisms of Cryotherapy as well as its various clinical applications regarding the treatment of numerous diseases and physical exercise recovery. The paper also details the possible limitations/detrimental effects of Cryotherapy usage.

Sea Level Rise And Public Perceptions Of Climate Change At Otter Point Creek Estuarine Reserve, Md, Haley A. Bechtel, Meghan L. Junis, Keylen Lucero Garcia

Student Publications

Freshwater tidal marshes are essential stopover points for migratory birds traveling up and down the east coast of North America. Given the importance of these habitats, we examined the effects of sea level rise on vegetation health and vegetation migration at Otter Point Creek Estuarine Reserve. We aimed to test three predictions: 1) vegetation health will decline over time during vegetation growth periods, 2) vegetation migration of less water-tolerant species will occur with movement into higher elevation plots, 3) people will be aware that there are impacts of climate change on species around them and themselves. We used a combination …

The Religious Lexicon Embedded In Public American Curricula, Daniel R. Jones

Student Publications

What is the relationship between one's own religious beliefs and their everyday colloquial diction choices? Moreover, why is the subfield that encompasses the intersection of sociolinguistics, education, and religious studies one that has gained little scholarly interest in recent years, where one could argue the importance of religious belief, and other socio-political beliefs in education have come center stage in the heart of American political debate? This article will tackle this broad range of topics through a case study focusing on my primary research question: How does a teacher’s own religious identity affect the religious language utilized in their classroom …

Epidemiology In Higher Education: Scarlet Fever At Gettysburg College, Addison E. Lomax

Student Publications

Throughout the early 20th century, the relationship between higher education and the spread of epidemic disease evolved in the United States. Two notable epidemics of scarlet fever in 1915 and 1920 serve as a lens through which the larger roles of disease and higher education can be analyzed. By assessing the roles both the administration and the students played at Gettysburg College, then Pennsylvania College, historians can understand the process of combating health crises in the future. Although the Pennsylvania College scarlet fever epidemics of 1915 and 1920 impacted campus to a smaller extent than the 2020 COVID-19 pandemic, the …

Leveraging Land Easements For Grassland Bird Habitat Conservation, Amy N. Marigliano, Hayden E. Dubniczki, Sarah W. Westrick

Student Publications

In addressing the decline of North American grassland bird populations, it is important to consider the various interdisciplinary approaches that can be employed in their conservation. OECMs, or “other effective area-based conservation measures” encompass a wide array of strategies which can be leveraged to conserve natural landscapes and species. Land easements implemented by the Land Conservancy of Adams County (LCAC) are an example of one such strategy. The LCAC seeks primarily to preserve the rural character of Adams County but has more recently turned their focus toward environmental conservation. In partnering with the Land Conservancy, this case study aimed to …