Digital Commons Network^™

Identifying Conditions For Indole Additions To Aldehydes To Be Applied To The Synthesis Of Phidianidine Analogues, Lindsay Newton, Anna Tingler

Undergraduate Research Competition

Phidianidines are natural products originally isolated from Phidiana Militaru, a shell-less mollusk. The compounds are comprised of an indole, a 1,2,4 oxadiazole ring, and an aminoalkylguanadine group on the C-3' position of the ring. They have been found to neutralize reactive oxygen species and are agonists of the µ-opioid receptor. Other groups have synthesized analogues of the phidianidines that have substituted the aminoalkylguanadine group for a biaryl ring system, which has been shown to have neuroprotective properties. The current synthetic routes make substitution of the indole and changing the oxadiazole difficult, so our goal is to create a synthesis that …

Environmental Bacteriophage Detection On Coastal Carolina University Campus, Hailey Oldfield, Madison Gentilo

Undergraduate Research Competition

The purpose of this study is to utilize bacteriophage as an environmental indicator of the presence of harmful bacteria in waterways on Coastal Carolina's campus and to identify bacteriophage that could be used to control bacterial blooms. Bacteriophages are viruses that infect bacteria. These viruses are found ubiquitously in the environment and are the most abundant organism on Earth. Eleven sites are designated for weekly sample collection. Water samples are filtered and amplified using strains of E. coli B and E. coli K12 to allow potential viruses in the sample to proliferate to detectable levels. Plaque assays are used as …

Isolation And Analysis Of Extracellular Vesicles From Lactic Acid Bacteria, L. Brooke Busby, Isabel Myers, Klea Hoxha

Undergraduate Research Competition

Extracellular Vesicles, also referred to as EVs, are spherical lipid membrane-bound vesicles produced by both Gram positive and Gram negative bacteria. These vesicles are secreted into the extracellular space and play important functions in cellular and host communication, elimination of competitors, virulence, detoxification of environmental stress, and nutrition sensing. They are often packed with proteins, enzymes, lipids, and nucleic acids like DNA or RNA molecules among other biological entities. Streptococcus thermophilus is a lactic acid bacterium (LAB), inhabiting the human digestive tract, that has been shown to produce EVs. The bacterial flora has a great impact on the host immune …

Commercially Geneticizing Race, Ethnicity, And Nation: The Implications Of The Discourse Surrounding Commercialized Genetic Tests On Identity, Kiara Jacoby

The Compass

No abstract provided.

The Compass, Issue 8

The Compass

No abstract provided.

How Do Site Characteristics Of Arkansas River Sandbars Affect Potential Predators Of Interior Least Tern Nesting Colonies?, Carice N. Godbey, Tom Nupp

ATU Scholars Symposium

Causes of colony failure in interior least terns (Sternula antillarum antillarum) have been a prevalent topic for researchers investigating this previously endangered species. How site features of their Arkansas River sandbar habitats may factor into the frequency or types of tern predators, however, is unknown. I am interested in identifying which characteristics of sandbars may result in higher frequencies of predator encounters for colonies and which predator species are involved. I used a trio of on-foot colony, site characteristic, and trail camera surveys from the summer 2020 and 2021 nesting seasons for my investigation. This exploratory analysis used …

2022 Urs Abstract Booklet, Undergraduate Research Center, Minnesota State University, Mankato

Undergraduate Research Symposium

Complete Schedule of Events for the 24th Annual Undergraduate Research Symposium at Minnesota State University, Mankato.

Developing A Growth Mindset For Teachers Of Secondary Students With Learning Disabilities, Jonathan L. Wilkins

Morehead State Theses and Dissertations

A capstone submitted in partial fulfillment of the requirements for the degree of Doctor of Education in the Ernst and Sara Lane Volgenau College of Education at Morehead State University by Jonathan L. Wilkins on April 12, 2022.

04-12-2022 Swosu Research & Scholarly Activity Fair Is Thursday, April 14, Southwestern Oklahoma State University

THE BARK ARCHIVE 2022

No abstract provided.

Two Magnaporthe Appressoria-Specific (Mas) Proteins, Momas3 And Momas5, Are Required For Suppressing Host Innate Immunity And Promoting Biotrophic Growth In Rice Cells, Ziwen Gong, Na Ning, Zhiqiang Li, Xin Xie, Richard Wilson, Wende Liu

Department of Plant Pathology: Faculty Publications

In the devastating rice blast fungus Magnaporthe oryzae, six Magnaporthe appressoria-specific (MAS) proteins are encoded by MoGAS1, MoGAS2 and MoMAS3–MoMAS6. MoGAS1 and MoGAS2 were previously characterized as M. oryzae virulence factors; however, the roles of the other four genes are unknown. Here, we found that, although the loss of any MAS gene did not affect appressorial formation or vegetative growth, ΔMomas3 and ΔMomas5 mutant strains (but not the others) were reduced in virulence on susceptible CO-39 rice seedlings. Focusing on ΔMomas3 and ΔMomas5 mutant strains, we found that they could penetrate …

Delta Conservation Topic For Hybrid Oxford Science Cafe, Edwin B. Smith

University of Mississippi News

Biologist Jason Hoeksema to discuss balancing wetland preservation with agricultural needs

Isolation Of Antibiotic Producing Bacteria From Local Soil, Sihlelelwe Joy Dlamini, Paige Julius

2022 Student Academic Showcase

Dr. Bewick and I have partnered with the Small World Initiative to transform our Introduction to Cellular and Molecular Biology lab into an authentic Course-based Undergraduate Research Experience (CURE). Our students are isolating bacteria from soil and testing to see if they produce antibiotics. The students haven't finished collecting data yet, so I am submitting this "dummy" abstract in place of their real abstract. The students are going to vote as a class on April 5 as to who should present at the SAC. We talked to Dr. Bagley earlier in the semester and she said this would be fine. …

Interneuronal Network Model Of Theta-Nested Fast Oscillations Predicts Differential Effects Of Heterogeneity, Gap Junctions And Short Term Depression For Hyperpolarizing Versus Shunting Inhibition, Guillem Via, Fernando R. Fernandez, John A. White, Carmen C. Canavier

Faculty Publications

No abstract provided.

Cngpld: Case-Control Copy-Number Analysis Using Gaussian Process Latent Difference, David J H Shih, Ruoxing Li, Peter Müller, W Jim Zheng, Kim-Anh Do, Shiaw-Yih Lin, Scott L Carter

Faculty, Staff and Student Publications

MOTIVATION: Cross-sectional analyses of primary cancer genomes have identified regions of recurrent somatic copy-number alteration, many of which result from positive selection during cancer formation and contain driver genes. However, no effective approach exists for identifying genomic loci under significantly different degrees of selection in cancers of different subtypes, anatomic sites or disease stages.

RESULTS: CNGPLD is a new tool for performing case-control somatic copy-number analysis that facilitates the discovery of differentially amplified or deleted copy-number aberrations in a case group of cancer compared with a control group of cancer. This tool uses a Gaussian process statistical framework in order …

Using Connections To Make Predictions On Dynamic Networks, Rebecca Dorff Jones

Theses and Dissertations

Networks are sets of objects that are connected in some way and appear abundantly in nature, sociology, and technology. For many centuries, network theory focused on static networks, which are networks that do not change. However, since all networks transform over time, static networks have limited applications. By comparison, dynamic networks model how connections between objects change over time. In this work, we will explore how connections in dynamic networks change and how we can leverage these changes to make predictions about future iterations of networks. We will do this by first considering the link prediction problem, using either Katz …

A Diverse Flea (Shiponaptera) Assemblage From The Small Mammals Of Central New Mexico, Dianne Esther Peterson

Biology ETDs

The geographical ranges of many mammals and their associated parasites are dynamic. Comprehensive documentation of these communities over time provides a foundation for interpreting how changing environmental conditions, driven by accelerating climate change, other anthropogenic disturbances, and natural events may influence host-parasite interactions. Fleas (Order Siphonaptera) are obligate, hematophagous parasites of birds and mammals with medical interest due to their role in transmitting pathogens. From 2016 to 2019, we sampled the small mammal and associated flea communities in El Malpais National Conservation Area (El Malpais) in Cibola County, New Mexico. Among 898 mammalian specimens, 925 fleas representing 29 species were …

Researchers Pioneering Long-Read Sequencing Studies Explain Why Long Reads Matter, Staff

Browse All News

No abstract provided.

Between Us: A Short Story Cycle, Kelly C. Wilcox

Honors College Theses

“Between us” is a short story cycle that alternative between the perspectives of two sisters, Skylar and Harmony, and their love interest–Michael. This thesis explores the various ways in which people differently respond to grief and the impacts grief has on lives, relationships, and families. These stories also review the roles race and identity play in the loss of a parent, specifically when the mother is of one race and the father is of another. This thesis contains the first two stories of the longer, in-progress collection.

Urinary Proteomic Profile Of Arterial Stiffness Is Associated With Mortality And Cardiovascular Outcomes, Dongmei Wei, Jesus D. Melgarejo, Lutgarde Thijs, Xander Temmerman, Thomas Vanassche, Lucas Van Aelst, Stefan Janssens, Jan A. Staessen, Peter Verhamme, Zhen-Yu Zhang

School of Medicine Publications

Background

The underlying mechanisms of arterial stiffness remain not fully understood. This study aimed to identify a urinary proteomic profile to illuminate its pathogenesis and to determine the prognostic value of the profile for adverse outcomes.

Methods and Results

We measured aortic stiffness using pulse wave velocity (PWV) and analyzed urinary proteome using capillary electrophoresis coupled with mass spectrometry in 669 randomly recruited Flemish patients (mean age, 50.2 years; 51.1% women). We developed a PWV‐derived urinary proteomic score (PWV‐UP) by modeling PWV with proteomics data at baseline through orthogonal projections to latent structures. PWV‐UP that consisted of 2336 peptides explained …

Artificial Intelligence And The Apocalyptic Imagination: The Ends Of Artificial Agency, Michael J. Paulus Jr.

Speakers & Events

The increasing role and power of artificial intelligence in our lives and world requires us to imagine and shape a desirable future with this technology. Since visions of AI often draw from Christian apocalyptic narratives, current discussions about technological hopes and fears present an opportunity for a deeper engagement with Christian eschatological resources. Dr. Paulus argues that the Christian apocalyptic imagination can transform how we think about and use AI, helping us discover ways artificial agency may participate in new creation.

Allie Cooke Crowned Miss Gardner-Webb, Alexa Key

Gardner-Webb NewsCenter Archive

Allie Cooke, of Hickory, N.C., was crowned Miss Gardner-Webb at the pageant held on March 27. Cooke, a first-year student, is double majoring in exercise science/biology and youth discipleship. Her platform is to raise awareness of St. Jude Children’s Research Hospital.

Academic Senate - Agenda, 4/12/2022, Academic Senate

Academic Senate Agendas

No abstract provided.

April 12, 2022 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Comments The Butte Reclamation Evaluation System (Bres) Draft 2021 Field Evaluation Of Reclaimed Sites Summary Report, 2021 Bres Field Evaluation Summary Report And Technical Recommendations Proposal (Dated March 11, 2022), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Machine Learning Analytics In Real Time For Health Services, Abolfazl Saghafi, Chris P. Tsokos

USF Patents

Methods and systems detect a random state change in a subject in real time. Eye state changes may be identified in encephalogram brain signals, or honeybee dance patterns may be classified. Multivariate signals including state change information are received via a plurality of channels. The signals are sampled and may be filtered to remove DC components. Statistical characteristics of the signals are monitored. When the statistical characteristics exceed a threshold during a critical time interval, a potential change of state is detected. The critical time segment of the signals may be filtered to generate respective state change artifact signals. The …

Washu Epigenome Browser Update 2022, Daofeng Li, Deepak Purushotham, Jessica K Harrison, Silas Hsu, Xiaoyu Zhuo, Changxu Fan, Shane Liu, Vincent Xu, Samuel Chen, Jason Xu, Shinyi Ouyang, Angela S Wu, Ting Wang

2020-Current year OA Pubs

WashU Epigenome Browser (https://epigenomegateway.wustl.edu/browser/) is a web-based genomic data exploration tool that provides visualization, integration, and analysis of epigenomic datasets. The newly renovated user interface and functions have enabled researchers to engage with the browser and genomic data more efficiently and effectively since 2018. Here, we introduce a new integrated panel design in the browser that allows users to interact with 1D (genomic features), 2D (such as Hi-C), 3D (genome structure), and 4D (time series) data in a single web page. The browser can display three-dimensional chromatin structures with the 3D viewer module. The 4D tracks, called 'Dynamic' tracks, animatedly …

Manifestations Of Alzheimer’S Disease Genetic Risk In The Blood Are Evident In A Multiomic Analysis In Healthy Adults Aged 18 To 90, Laura Heath, John C. Earls, Andrew T. Magis, Sergey A. Kornilov, Jennifer C. Lovejoy, Cory C. Funk, Noa Rappaport, Benjamin A. Logsdon, Lara M. Mangravite, Brian W. Kunkle, Eden R. Martin, Adam C. Naj, Nilüfer Ertekin-Taner, Todd E. Golde, Leroy Hood, Nathan D. Price, Erin Abner, David W. Fardo, Linda J. Van Eldik, Alzheimer’S Disease Genetics Consortium

Sanders-Brown Center on Aging Faculty Publications

Genetics play an important role in late-onset Alzheimer’s Disease (AD) etiology and dozens of genetic variants have been implicated in AD risk through large-scale GWAS meta-analyses. However, the precise mechanistic effects of most of these variants have yet to be determined. Deeply phenotyped cohort data can reveal physiological changes associated with genetic risk for AD across an age spectrum that may provide clues to the biology of the disease. We utilized over 2000 high-quality quantitative measurements obtained from blood of 2831 cognitively normal adult clients of a consumer-based scientific wellness company, each with CLIA-certified whole-genome sequencing data. Measurements included: clinical …

Garnet & Black Spring 2022, University Of South Carolina, Office Of Student Media

Garnet & Black Magazine

No abstract provided.

Genomic Time Machine, Beth Potier

UNH Today Archive

No abstract provided.

Investigation To Discover Antibiotic Producing Soil Bacteria, Sophia Juliana, Joscelyn White, Sydney Mcash

2022 Student Academic Showcase

Dr. Bewick and I have partnered with the Small World Initiative to transform our Introduction to Cellular and Molecular Biology lab into an authentic Course-based Undergraduate Research Experience (CURE). Our students are isolating bacteria from soil and testing to see if they produce antibiotics. The students haven't finished collecting data yet, so I am submitting this "dummy" abstract in place of their real abstract. The students are going to vote as a class on April 5 as to who should present at the SAC. We talked to Dr. Bagley earlier in the semester and she said this would be fine. …