Digital Commons Network^™

Europium-Doped Cerium Oxide Nanoparticles For Microglial Aβ Clearance And Homeostasis, Jatin Machhi, Pravin Yeapuri, Milica Markovic, Milankumar Patel, Wenhui Yan, Yaman Lu, Jacob D. Cohen, Mahmudul Hasan, Mai Mohamed Abdelmoaty, You Zhou, Huangui Xiong, Xinglong Wang, R. Lee Mosley, Howard E. Gendelman, Bhavesh D. Kevadiya

Nebraska Center for Biotechnology: Faculty and Staff Publications

Alzheimer’s disease (AD) is the most common neurodegenerative disorder. Pathologically, it is characterized by the deposition of amyloid beta (Aβ) plaques and presence of neurofibrillary tangles. These drive microglia neuroinflammation and consequent neurodegeneration. While the means to affect Aβ plaque accumulation was achieved how it affects disease outcomes remains uncertain. Cerium oxide (CeO₂) reduces Aβ plaques, oxidative stress, inflammation, and Alzheimer’s disease (AD) signs and symptoms. Specifically, CeO₂ nanoparticles (CeO₂NPs) induces free radical scavenging and cell protective intracellular signaling. This can ameliorate the pathobiology of an AD-affected brain. In order to investigate, CeO₂NPs …

Winds Of Change, Rebecca Irelan

UNH Today Archive

No abstract provided.

Salve Regina University Act On Climate: Strategic Plan For The University To Reach State Carbon Neutrality Goals, Jameson Chace, Jared Barrows, Casey Bermingham, Dylan Bigansky, Avery Braccia, Natalie Bryant, Claire Cavanagh, Jerry Cheatham, Alexander Colon, Courtney Connor, John Deady, Mary Duman, Mia Farley, Alexander Gajic, Brandon Grover, Andrew Hassler, Dhana Hinds, Abigail Hoye, Emma Karpinski, Finn Doherty, Genevieve Mcclelland, Stella Mccormack, Maggie Mccue, Emma Mcgrillen, Kelly Mckenna, Gianfranco Messina, Liam Murphy, Maeve Newton, Mia Pastorok, Tyler Petrosino, Samuel Richard, Marion Riddle, Allison Sagun, Jessica Serra, Aidan Tucker, Patrick Voli

BIO140 Carbon Footprint Project

In order to become more sustainable and meet the mandate set by the 2021 Rhode Island Act on Climate law (RI General Law §42-6.2), Salve Regina University must work to reach net-zero greenhouse gas emissions by the year 2050. Action to meet these standards begins now and must be continually built upon to ensure that Salve Regina University, as leader in Rhode Island, is always working for a more sustainable future. Throughout the Spring 2022 semester, students of the BIO-140: Humans and Their Environment course instructed by Dr. Jameson Chace have researched ways in which Salve Regina can begin on …

Discussion On Action Strategies Of China’S Carbon Peak And Carbon Neutrality, Guirui Yu, Tianxiang Hao, Jianxing Zhu

Bulletin of Chinese Academy of Sciences (Chinese Version)

China's carbon peak and carbon neutrality action is a huge system engineering with national coverage, country-led and universal participation, long-term sustainable implementation, requiring definite, tenacious, and adaptable action strategies. Here, based on summarizing the current situations of "carbon peak and carbon neutrality", the action strategies, technological approaches, and scientific and technological supports are discussed to achieve the "dual carbon" targets in China. It is suggested that China's "dual carbon" action should insist on "one basic concept", achieve "two macroscopic targets", implement the "three-pronged comprehensive", and "four-way simultaneous" technological paths, and practice the macro layout of "five coordination" in the national …

Policy Approaches To Increase Carbon Sequestration Capacity By Optimizing Layouts Of Ecological Construction, Jie Fan, Hongbing Wang, Daojing Zhou, Ning Ma, Baoyin Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Improving carbon sequestration capacity through ecological construction is one of the important ways to achieve the goal of "carbon neutrality" in China. Based on the analysis of the current situation and trend of ecological carbon sequestration in China, this study summarizes the main challenges in the increment of ecosystem carbon sink in China. The current situation and trend, the significant carbon sequestration capacity of forests, the recovery phase of carbon sequestration capacity of grassland, and the carbon sequestration benefits of major ecological projects are also surveyed. Then, the new challenges of China are analyzed, including the backlog of over-mature forests …

Technological Approaches To Enhance Ecosystem Carbon Sink In China: Nature-Based Solutions, Guirui Yu, Jianxing Zhu, Li Xu, Nianpeng He

Bulletin of Chinese Academy of Sciences (Chinese Version)

Carbon peak in 2030 and carbon neutralization in 2060 has been established as one of the important strategic goals of China's economic and social development. During 2010-2020, the capacity of terrestrial ecosystems in China to sequester carbon dioxide (CO2) varied from 1.0 to 1.3 Gt/a, with high uncertainty. To enhance the carbon sink capacity of Chinese terrestrial ecosystems, the combination with land space planning and ecological protection is essential. It is necessary to first stabilize the existing carbon storage in these ecosystems, such as forest, grassland, wetland, coast, and others, and then implement some important ecological protection and ecological restoration …

The Parthenon, April 20, 2022, Tyler Spence, Connor Woodruff, Tyler Kennett, Evan Green, Shauntelle Thompson, Rafael Alfonso, Abby Hanlon, Abby Ayes, Alaina Laster, Isabella Robinson

The Parthenon

No abstract provided.

Carbon Neutral Transformative Technologies For Industrial Process, Suojiang Zhang, Xiangping Zhang, Wei Ge, Chunyan Shi

Bulletin of Chinese Academy of Sciences (Chinese Version)

Focusing on the four major high carbon emission industries of steel, non-ferrous, chemical industry and building materials, through research and analysis, four low carbon strategies, i.e., green hydrogen/green electricity substitution, raw material/product structure adjustment, process flow re-construction and digital intelligence, are proposed. Combining the current status and the trends of technology development in different industries, a number of advanced low-carbon technologies are suggested, key scientific and technological challenges to be solved are condensed, and suggestions and initiatives to accelerate the application of new technologies and industrial transformation and upgrading are proposed, with a view to providing support for low-carbon and …

The Role Of Wolves In Regulating A Chronic Non-Communicable Disease, Osteoarthritis, In Prey Populations, Sarah Hoy, John A. Vucetich, Rolf O. Peterson

Michigan Tech Publications, Part 1

It is widely accepted that predators disproportionately prey on individuals that are old, weak, diseased or injured. By selectively removing individuals with diseases, predators may play an important role in regulating the overall health of prey populations. However, that idea is seldom tested empirically. Here we assess the extent that wolves (Canis lupus) select adult moose (Alces alces) in Isle Royale National Park on the basis of age-class and osteoarthritis, a chronic, non-communicable disease. We also assess how temporal variation in kill rates (on moose by wolves) were associated with the subsequent incidence of osteoarthritis in the moose population over …

A Roadmap To Doing Culturally Grounded Developmental Science, Tanya Broesch, Sheina Lew-Levy, Michelle Kline, Joscha Kärtner, Patricia Kanngiesser

School of Psychology

This paper provides a roadmap for engaging in cross-cultural, developmental research in practical, ethical, and community-engaged ways. To cultivate the flexibility necessary for conducting cross-cultural research, we structure our roadmap as a series of questions that each research program might consider prior to embarking on cross-cultural examinations in developmental science. Within each topic, we focus on the challenges and opportunities inherent to different types of study designs, fieldwork, and collaborations because our collective experience in conducting research in multiple cultural contexts has taught us that there can be no single “best practice”. Here we identify the challenges that are unique …

Lessons From The Western Atlantic Lionfish Invasion To Inform Management In The Mediterranean, Aylin Ulman, Fadilah Z. Ali, Holden E. Harris, Mohammad Adel, Sara A.A.Al Mabruk, Michel Bariche, Allison C. Candelmo, Jennifer K. Chapman, Burak Ali Çiçek, Kaylin R. Clements, Alexander Q. Fogg, Stacy Frank, Stephen R. Gittings, Stephanie J. Green, Jason M. Hall-Spencer, Jim Hart, Summer Huber, Philip E. Karp, Fabian C. Kyne, Demetris Kletou, Lauryn Magno, Shevy B.S. Rothman, Jennifer N. Solomon, Nir Stern, Taner Yildiz

School of Biological and Marine Sciences

Major invasions of Indo-Pacific lionfish (Pterois volitans and P. miles) are underway in the Western Atlantic Ocean and the Mediterranean Sea. While the establishment of lionfish in the Western Atlantic is perhaps the most well-studied marine fish invasion to date, the rapidly expanding invasion in the Mediterranean is more recent and has received less attention. Here we review and synthesize successes and failures from two decades of lionfish management in the Western Atlantic to give policy recommendations for their management in the Mediterranean. Two failed approaches that were attempted multiple times in the Western Atlantic and that we advise against …

Ibrutinib Attenuated Dss-Induced Ulcerative Colitis, Oxidative Stress, And Inflammatory Cascade By Modulating Pi3k/Akt And Jnk/Nfκb Pathways, Liangliang Hao, Lina Tariq Alkury, Abdullah Alattar, Muhammad Faheem, Reem Alshaman, Fawad Ali Shah, Shupeng Li

All Works

No abstract provided.

Attention/Deficit Hyperactivity Disorder In Adolescent And Young Adult Males With Fragile X Syndrome, Jessica Klusek, Shannon L. O'Connor, Alexandra Hickey, Kimberly J. Hills, Leonard Abbeduto, Jane E. Roberts

Faculty Publications

This study characterized the rates of rates of attention-deficit/hyperactivity disorder (ADHD) in adolescent and young adult males with fragile X syndrome (FXS) using a multi-method approach integrating a DSM-based parent interview (Children’s Interview for Psychiatric Syndromes; P-ChIPS, Fristad et al., 1998) and a parent rating scale (Child Behavior Checklist; CBCL, Achenbach, 2001). Thirty-one males with FXS, aged 16-24 years, participated. Forty-two percent met DSM-5 criteria for ADHD and 35% exceeded the CBCL cut-offs. Agreement between the two classification methods was fair (κ=0.38). Autism symptom severity and nonverbal cognitive ability did not predict ADHD diagnoses/symptoms. Results show …

Targeted Therapy In The Management Of Modern Craniopharyngiomas, Maikerly Reyes, Mohammad Taghvaei, Siyuan Yu, Anish Sathe, Sarah Collopy, Giyarpuram Prashant, James J. Evans, Michael Karsy

Department of Neurosurgery Faculty Papers

Background: The proximity of craniopharyngiomas (CPs) to critical neurovascular structures can lead to a host of neurologic and endocrine complications that lead to difficulty with surgical management. In this review, we examine the molecular and genetic markers implicated in CP, their involvement in tumorigenic pathways, and their impact on CP prognosis and treatment.

Methods: We undertook a focused review of relevant articles, clinical trials, and molecular summaries regarding CP.

Results: Genetic and immunological markers show variable expression in different types of CP. BRAF is implicated in tumorigenesis in papillary CP (pCP), whereas CTNNB1 and EGFR are often overexpressed in adamantinomatous …

Impact Of Interleukin-34 On The Promotion Of Bone Osteolysis And Neuroinflammation In Experimental Models Of Alzheimer’S Disease, Anny Ho

All HCAS Student Capstones, Theses, and Dissertations

Alzheimer’s disease (AD) is a growing health concern and is the most common type of dementia worldwide. Emerging evidence indicates that aggregated amyloid-beta (Aβ) peptides, one of the hallmark features of AD neuropathology, can increase RANKL-mediated osteoclast activity leading to the prevalence and severity of inflammatory osteolysis, e.g., osteoporosis and periodontal bone loss. Conversely, osteolytic lesions are associated with increased risk of dementia diagnosis indicating that there is a direct link between dementia and inflammatory osteolysis. It was demonstrated that the neuronal cells primarily produce interleukin-34 (IL-34) and microglia, macrophages, and osteoclast precursors express colony-stimulating factor 1 receptor (CSF-1R), a …

How Non-Product-Specific Manufacturing Patents Block Biosimilars, Chorong Song

Duke Law Journal

A new class of drugs called biologics has potential to finally cure previously untreatable conditions such as cancer and Alzheimer’s disease. But there is a catch: these innovative drugs are expensive. On average, prices range from $10,000 to $30,000 per year, and the most expensive ones exceed $500,000. The Biologics Price Competition and Innovation Act (“BPCIA”) was passed in 2010 to lower prices by providing a new regulatory pathway in approving biosimilars––copies of brand-name biologics. Yet, the BPCIA’s promised regulation of drug prices has not materialized partly due to brand-name companies’ vast patent portfolios, also known as patent thickets. This …

Bci Validation: Yfiler Plus Kit Validation, Chloe Koon

Honors Projects

In order to have access and use the Combined DNA Index System (CODIS), it is required by the Federal Bureau of Investigation's Quality Assurance Standards (FBI-QAS) for Forensic DNA Units to complete comprehensive validation studies on all equipment, materials, and methods used in the process of DNA analysis. This study continues validation previous done within the Ohio Bureau of Criminal Investigation (BCI). YFiler Plus is a DNA amplification kit that is used in cases where it is most useful to examine only male DNA profile(s) within a sample by amplifying loci only on the Y-Chromosome. Components of this study include …

Dynamics Of Huntingtin Protein Interactions In The Striatum Identifies Candidate Modifiers Of Huntington Disease, Todd M Greco, Christopher Secker, Eduardo Silva Ramos, Joel D Federspiel, Jeh-Ping Liu, Alma M Perez, Ismael Al-Ramahi, Jeffrey P Cantle, Jeffrey B Carroll, Juan Botas, Scott O Zeitlin, Erich E Wanker, Ileana M Cristea

Duncan NRI Faculty and Staff Publications

Huntington’s disease (HD) is a monogenic neurodegenerative disorder with one causative gene, huntingtin (HTT). Yet, HD pathobiology is multifactorial, suggesting that cellular factors influence disease progression. Here, we define HTT protein-protein interactions (PPIs) perturbed by the mutant protein with expanded polyglutamine in the mouse striatum, a brain region with selective HD vulnerability. Using metabolically labeled tissues and immunoaffinity purification-mass spectrometry, we establish that polyglutamine-dependent modulation of HTT PPI abundances and relative stability starts at an early stage of pathogenesis in a Q140 HD mouse model. We identify direct and indirect PPIs that are also genetic disease modifiers using in-cell two-hybrid …

Cross-Reactive Antibodies Elicited To Conserved Epitopes On Sars-Cov-2 Spike Protein After Infection And Vaccination., Eric S. Geanes, Cas Lemaster, Elizabeth Fraley, Santosh Khanal, Rebecca Mclennan, Elin Grundberg, Rangaraj Selvarangan, Todd Bradley

Manuscripts, Articles, Book Chapters and Other Papers

SARS-CoV-2 is a novel betacoronavirus that caused coronavirus disease 2019 and has resulted in millions of deaths worldwide. Novel coronavirus infections in humans have steadily become more common. Understanding antibody responses to SARS-CoV-2, and identifying conserved, cross-reactive epitopes among coronavirus strains could inform the design of vaccines and therapeutics with broad application. Here, we determined that individuals with previous SARS-CoV-2 infection or vaccinated with the Pfizer-BioNTech BNT162b2 vaccine produced antibody responses that cross-reacted with related betacoronaviruses. Moreover, we designed a peptide-conjugate vaccine with a conserved SARS-CoV-2 S2 spike epitope, immunized mice and determined cross-reactive antibody binding to SARS-CoV-2 and other …

Dancing With 4e Cognitive Science And Human Science Psychology, Joshua Hall

Middle Voices

According to the “Embodied Cognition” entry in the Stanford Encyclopedia of Philosophy, the three landmark texts in the 4E cognitive science tradition are Lakoff and Johnson’s Metaphors We Live By, Varela, Thompson, and Rosch’s The Embodied Mind, and Andy Clark’s Being There. In my first section, I offer a phenomenological interpretation of these three texts, identifying recuring affirmations of the figure of dance alongside explicit marginalization of the practice of dance, perhaps in part due to cognitive science’s overemphasis on cognition to the exclusion of affect. In my second section, drawing on my previous interpretations of proto-affect theorists …

Tea And Cardiovascular Diseases, Liyan Song, Bernard My Cheung, Marcel Wl Koo, Chu-Pak Lau

Journal of the Hong Kong College of Cardiology

Tea, produced from the tea plant Camellia sinensis, has been consumed as a popular beverage world wide for thousands of years. Catechins are the major constituents in tea that contribute to its biological effects. The anti-thrombogenic, anti-inflammatory anti-hypertensive, and protective effects of tea on endothelium have been widely investigated for decades. Although studies have produced inconsistent results of the protective effect of tea on the cardiovascular system, a relationship between tea consumption and inhibition of cardiovascular diseases has been found in both animal and human studies. The mechanisms of action of tea have also been elucidated in cellular and molecular …

Same-Gender Pathways To Parenthood, Sydney T. Inger

James Madison Undergraduate Research Journal (JMURJ)

LGBTQ+ individuals and couples who want children negotiate systemic inequalities in the United States of America. This literature review surveys America’s confusing legal map and the gaps in its enduring scholarly theories. The paper then examines the challenges that LGBTQ+ individuals and couples confront in working through the common pathways—same-gender adoption and fostering, in vitro fertilization, and surrogacy—to become parents. Dispersing information on the pathways will be a positive step towards breaking down the inequities for those in the LGBTQ+ community who want to start a family.

The Transmission Of Intergenerational Trauma: Conversations With Mental Health Professionals, Donnielle Woods Msw Candidate, Kayla Horner Msw Candidate, Adam Quinn Ph. D., Msw

Thinking Matters Symposium

Intergenerational trauma refers to the impact a traumatic experience has on subsequent generations that were not directly exposed to the original traumatic event. Existing research has shown that trauma affects subsequent generations biologically, culturally, and emotionally. The current study explored the question: To what extent, if any, does intergenerational trauma affect and transmit among African and Middle Eastern American subgroups living in Portland, Maine? This qualitative study utilized a phenomenological approach. Semi-structured, in-depth interviews were conducted with staff employed at local agencies who work directly with African and Middle Eastern migrant families. We hypothesized that intergenerational trauma is being transmitted …

Orthodontic Treatment Of Severe Bimaxillary Dentoalveolar Protrusion With Skeletal Class Ii Malocclusion Without Using Miniscrews, Yi-Wei Huang, Chun-Liang Kuo, I-Hua Liu, Yu-Ling Tsai, Chung-Li Wang, Chun-Hsiu Yang

Taiwanese Journal of Orthodontics

Bimaxillary dentoalveolar protrusion is characterized by the proclined anterior teeth, protrusive lips, and a convex profile. A proper orthodontic treatment modality for efficient anchorage control is necessary to retract the anterior teeth and improve the facial esthetics significantly. The commonly used miniscrew could provide absolute anchorage, however, it is accompanied by some risks and complications, especially in adolescent females. This case report described a 16-year-old female with diagnosis of skeletal Class II, normal mandibular plane angle, and Angle Class I malocclusion associated with proclined upper and lower anterior teeth, excessive overjet, and a convex profile with lip incompetence. We extracted …

Index For Volume 80, Florida Historical Society

Florida Historical Quarterly

No abstract provided.

Book Reviews, Florida Historical Society

Florida Historical Quarterly

Fuson, Juan Ponce de Leon and the Spanish Discovery of Puerto Rico and Florida. By Charles W. Arnade; McEwan, ed., Indians of the Greater Southeast: Historical Archaeology and Ethnohistory. By James Taylor Carson; Craig, Spanish Colonial Silver Coins in the Florida Collection. By Roger C. Smith; Cashin, William Bartram and the American Revolution on the Southern Frontier. By J. Russell Snapp; O'Shaughnessy, An Empire Divided: The American Revolution and the British Caribbean. By Robert L. Paquette; Massey, John Laurens and the American Revolution. By Robert Olwell; Johnson, Soul by Soul: Life Inside the Antebellum Slave Market. By Jeffrey Robert Young; …

Green Awakening: Social Activism And The Evolution Of Majory Stoneman Douglas's Environmental Consciousness, Jack E. Davis

Florida Historical Quarterly

Late in life, Marjory Stoneman Douglas earned a reputation a an impassioned and outspoken environmentalist. Her antiquity, warrior-like spirit, and signature wide-brim hats made her a darling of the media. From Ms. and Rolling Stone magazines to the smallest village newspapers of Florida, journalists called her "Our Lady of the Glades," "Grand Dame of the Everglades," "Guardian of the Glades," "Guardian of the Glades' Spirit," "First Lady of the Everglades," "Empress of the Everglades," "Champion of Everglades," and "Everglades Evangelist." She received countless honorary degrees, medals, and awards. At age 102, she was Honorary Chair of the Conference on the …

Title Page, Florida Historical Society

Florida Historical Quarterly

Title page for Volume 80, Number 1. Includes the Table of Contents

Student-Developed Laboratory Activities Using Rolling Object On An Inclined Plane To Improve Student Learning, Qing Shao, Joseph Ametepe

Georgia Journal of Science

This work presents an alternative method of teaching undergraduate introductory physics laboratory. Students are presented with an experimental scenario “Rolling object on an inclined plane” and guided to develop their own laboratory activities in a studio-style setting. The overall goal of this alternative approach is to shift part of the learning responsibility to students. Through guided self-developed activities, students establish the connections between different physics concepts. Such a shift makes students active participants in the classroom, allows them to explore ideas independently, and discover through doing the exploring. Furthermore, the pedagogy is aimed at (i) motivating and actively engaging students …

Addressing Stem Gender Disparity, Liesl Carter

Line by Line: A Journal of Beginning Student Writing

I had written this piece under my English 198 class theme of gender. I wanted to explore why there is a continued gender gap in STEM. I had researched and analyzed articles that worked to explain this concept. I then conducted personal research in the form of a survey and interview to apply my findings to personal life experiences particularly at the University of Dayton. My overall writing process included research and analysis written into numerous drafts which were reviewed by both peers and my professor.