Digital Commons Network^™

Reduction Of Mutant Atxn1 Rescues Premature Death In A Conditional Sca1 Mouse Model, James P Orengo, Larissa Nitschke, Meike E Van Der Heijden, Nicholas A Ciaburri, Harry T Orr, Huda Y Zoghbi

Duncan NRI Faculty and Staff Publications

Spinocerebellar ataxia type 1 (SCA1) is an adult-onset neurodegenerative disorder. As disease progresses, motor neurons are affected, and their dysfunction contributes toward the inability to maintain proper respiratory function, a major driving force for premature death in SCA1. To investigate the isolated role of motor neurons in SCA1, we created a conditional SCA1 (cSCA1) mouse model. This model suppresses expression of the pathogenic SCA1 allele with a floxed stop cassette. cSCA1 mice crossed to a ubiquitous Cre line recapitulate all the major features of the original SCA1 mouse model; however, they took twice as long to develop. We found that …

2022 April 22- Board Of Trustees Academic, Research, And Student Success Committee Agenda And Minutes, Board Of Trustees, East Tennessee State University

Board of Trustees Agendas and Minutes

No abstract provided.

Development Of A Non-Invasive Dna Extraction Method From Teeth, Monalisa Heng

Honors Theses

Forensic dentistry has evolved from simple morphological investigations to genetic and molecular analysis. One of the most important techniques is DNA analysis which requires viable samples from an individual or crime site. The orofacial region can be a good source for DNA samples because the tissues can resist environmental, thermal, electrical, and mechanical challenges. Teeth are especially useful as a source of genetic material because the DNA located in the pulp is surrounded by protective mineral tissue. The DNA in the pulp tissue is currently accessed through destructive methods involving crushing, pulverization, and splitting the tooth. Unfortunately, destructive methods destroy …

A Somatic Mutation In Moesin Drives Progression Into Acute Myeloid Leukemia, Ouyang Yuan, Jeffrey A Magee, Et Al.

Open Access Publications

Acute myeloid leukemia (AML) arises when leukemia-initiating cells, defined by a primary genetic lesion, acquire subsequent molecular changes whose cumulative effects bypass tumor suppression. The changes that underlie AML pathogenesis not only provide insights into the biology of transformation but also reveal novel therapeutic opportunities. However, backtracking these events in transformed human AML samples is challenging, if at all possible. Here, we approached this question using a murine in vivo model with an MLL-ENL fusion protein as a primary molecular event. Upon clonal transformation, we identified and extensively verified a recurrent codon-changing mutation (Arg

The Geriatric Emergency Care Applied Research (Gear) Network Approach: A Protocol To Advance Stakeholder Consensus And Research Priorities In Geriatrics And Dementia Care In The Emergency Department, Ula Hwang, Christopher Carpenter, Scott Dresden, Jeffrey Dussetschleger, Angela Gifford, Ly Hoang, Jesseca Leggett, Armin Nowroozpoor, Zachary Taylor, Manish Shah, The Gear And Gear 2.0 Networks

Open Access Publications

INTRODUCTION: Increasingly, older adults are turning to emergency departments (EDs) to address healthcare needs. To achieve these research demands, infrastructure is needed to both generate evidence of intervention impact and advance the development of implementation science, pragmatic trials evaluation and dissemination of findings from studies addressing the emergency care needs of older adults. The Geriatric Emergency Care Applied Research Network (https://gearnetwork.org) has been created in response to these scientific needs-to build a transdisciplinary infrastructure to support the research that will optimise emergency care for older adults and persons living with dementia.

METHODS AND ANALYSIS: In this paper, we describe our …

The Effect Of Estrogen On Gdnf Production Of Skeletal Muscle In Vitro, Hope Welter

Honors Theses

As life expectancy continues to rise, the number of people over age 65 in the U.S. is increasing. An aging population brings with it impacts on the national health system and associated economic expenditures. As individuals age, the skeletomuscular system suffers reduced function due to disease or conditions such as sarcopenia. Sarcopenia is characterized by muscular atrophy resulting from reduced muscle innervation. Exercise has been linked to prevention of sarcopenia, a suspected result of increased production of glial cell line-derived neurotrophic factor (GDNF). GDNF promotes neuronal survival, regeneration, and the formation of neuromuscular junctions. Therefore, treatments like exercise that increase …

Literature Review On Outer Hair Cell Regeneration And Potential Hearing Restoration, Serena Karlov

Honors Theses

The cochlea is the portion of the inner ear responsible for hearing, containing both the organ of Corti and auditory hair cells. Sound wave vibrations mechanically bend the stereocilia on the three rows of outer hair cells and one row of inner hair cells. These hair cells transduce this mechanical energy into electrical impulses that are relayed from the auditory nerve to the brain, where sounds are processed. In this review I provide an overview of inner ear anatomy, ear physiology, and auditory transduction. I then move on to specifically focus on the importance of outer hair cells, their regeneration, …

Comparing Behavioral Activation With And Without A Values Component: A Systematic Review, Natalie Komoll

Honors Theses

Major depressive disorder is one of the most prevalent psychological disorders within the global population and has been for many years. Over the years, numerous interventions have been developed to treat major depressive disorder, including cognitive-behavioral therapy. One form of cognitive-behavioral therapy for depression, known as behavioral activation, focuses on increasing contact with pleasant activities that are reinforcing. Many modifications of behavioral activation have been made over the years, including the version Martell and colleagues (2010) created which modified the traditional approach by decreasing the number of sessions. This new approach, known as brief behavioral activation, also asks clients to …

Three-Heartbeat Multilead Ecg Recognition Method For Arrhythmia Classification, Liang-Hung Wang, Yan-Ting Yu, Wei Liu, Lu Xu, Chao-Xin Xie, Tao Yang, I-Chun Kuo, Xin-Kang Wang, Jie Gao, Patricia Angela R. Abu

Department of Information Systems & Computer Science Faculty Publications

Electrocardiogram (ECG) is the primary basis for the diagnosis of cardiovascular diseases. However, the amount of ECG data of patients makes manual interpretation time-consuming and onerous. Therefore, the intelligent ECG recognition technology is an important means to decrease the shortage of medical resources. This study proposes a novel classification method for arrhythmia that uses for the very first time a three-heartbeat multi-lead (THML) ECG data in which each fragment contains three complete heartbeat processes of multiple ECG leads. The THML ECG data pre-processing method is formulated which makes use of the MIT-BIH arrhythmia database as training samples. Four arrhythmia classification …

Editorial: Interspecies Interactions Within Fermented Food Systems And Their Impact On Process Efficiency And Product Quality, Brian Gibson, Jian Zhao, Rosane Freitas Schwan

Research Outputs: 2025-Present

No abstract provided.

Debunking Medical Myths: Msg Safety, Meyer Gershater, Gabriella Shab, Amanda Rodriguez, Ahmad Chouman, Anthony Mrocko

Patient Education Projects

No abstract provided.

Debunking Medical Myths: Microwave Radiation Cause Cancer?, Bethani Dunlap, Andrew Mizerowski, Andrew Kirmse, Shirley Elfishawy, Nicole Naidoo, Jacob Sullivan

Patient Education Projects

No abstract provided.

Towards Asymmetric Mannich Reactions And Alkylation Of Indoles, Bianco Bicalho

Honors Theses

In the presence of trimethylsilyl trifluoromethanesulfonate (TMSOTf) and 2,6-lutidine, acylated thiones undergo Aldol and Mannich reactions with aldehydes and nitrones to yield complex nitrogen-containing compounds. The use of a chiral metal-ligand complex is hypothesized to accelerate the reaction and increase stereochemical control during product formation. N-Alkylindoles undergo Friedel-Crafts alkylation with acetates in the presence of TMSOTf and 2,6-lutidine to produce 3-alkyl indoles. Varying Substitution on the indole at the 5 position and removal of the alkyl group from the 1 position both show continued reactivity at the 3 position even in the presence of TMSOTf.

Assemblage Composition And Vertical Distributions Of Deep-Sea Anglerfishes (Suborder: Ceratioidei) Of The Northern Gulf Of Mexico, Kimberly S. Schmutz

All HCAS Student Capstones, Theses, and Dissertations

The bathypelagic zone, despite being the largest cumulative ecosystem on the planet, represents the largest data gap in biological oceanography. In a deep environment with no solar light and pressures so high that survival is impossible for most marine organisms, some species have been able to adapt and overcome these challenges to radiate into diverse and successful taxa. Among the most notable of these successful taxa are the deep-sea anglerfishes (Lophiiformes: Ceratioidei). Ceratioid anglerfishes possess unique adaptations such as a symbiotic bioluminescent lure (females) and extreme dwarfism (males) that make them a particularly interesting group to study. Despite this research …

Using A Tracer Test To Assess The Fate And Transport Of Nitrate In A Saturated Buffer Zone, Alhassan Sahad Sahad

Theses and Dissertations

The Upper Mississippi Basin (UMB), which includes Illinois, has highly fertile soils and therefore, experiences intensive agricultural practices. While fertile, the soils do not drain well, resulting in the installation of tile-drainage systems. Agricultural practices within the UMB involves the application of nitrogen (N)-rich fertilizers. The tile systems coupled with the application of N fertilizers have led to the excessive export of nitrates as nitrogen (NO3-N) from the agricultural fields into surface and subsurface waters through subsurface tile drainage systems. Excess NO3-N contributes to eutrophication and to development of hypoxic zones in aquatic environments. One method that has exhibited success …

Change Of Air Quality Knowledge, Perceptions, Attitudes, And Practices During And Post-Wildfires In The United States, Alessandro Del Ponte, Lina Ang, Lianjun Li, Noah Lim, Wilson Tam Wai San, Wei Jie Seow

Political Science Faculty Articles and Research

Amid worsening climate change, the recurrent wildfires have substantially worsened air quality in the Western United States (U.S.). Understanding the knowledge, attitudes, perception, and practices (KAPP) over time in response to natural disasters such as wildfires is crucial for public health interventions and disaster preparedness. This is the first study to investigate the change in air quality KAPP over time in response to natural disasters. Previous studies have only assessed KAPP at a fixed time point. Using a two-wave panel survey (during and post-wildfires), we assessed the association between KAPP and respiratory health indicators as well as the changes over …

Detection Of Bacteria In Food, Sumalee Kondo

Asian Medical Journal and Alternative Medicine

No abstract provided.

Prevalence Of Commonly Abused Drugs Detected From Drug Testing In Unnatural Death Cases During 1-Year Period At Thammasat University Hospital, Aphinan Tangsermkijsakul, Tossanai Pipatchotitham

Asian Medical Journal and Alternative Medicine

Objective: To determine the prevalence of commonly abused drugs (CAD) detected in unnatural death cases at Thammasat University Hospital (TUH) in 1 year and also evaluate drug prevalence data to propose appropriate toxicology panels used for autopsied deaths at TUH.
Methods: A descriptive cross-sectional study was conducted and unnatural death cases in 5 police stations sent to TUH for a medico-legal investigation from March 2020 to February 2021 were recruited in this study. All police records and autopsy reports were documented for demographic data. In this study, drug preliminary tests were performed with rapid chromatographic immunoassay test kits for 5 …

Parkinson’S Disease Classification From Data Collected Using Smartphone: A Review Of The Literature, Decho Surangsrirat, Warisara Asawaponwiput, Natsue Yoshimura, Apichart Intarapanich, Denchai Worasawate

Asian Medical Journal and Alternative Medicine

Currently, diagnosis or severity assessment of a movement disorder is based on clinical observation. Therefore, it is highly dependent on the skills and experiences of the trained specialist who performs the procedure. In order to quantify the disease and severity systematically, we investigate the studies on the feasibility of using a smartphone for the diagnosis of Parkinson’s disease (PD). The mPower dataset is one of the largest, open to researcher access, PD studies. It is a mobile application-based study for monitoring key indicators of PD progression. Data from seven modules with a total of 8,320 participants who provided the data …

Role Of Atogepant In The Treatment Of Episodic Migraines: Clinical Perspectives And Considerations, Fred Cohen, Hsiangkuo Yuan

Department of Neurology Faculty Papers

Advances in molecular biology and neuroscience have led to the discovery of calcitonin gene-related peptide (CGRP), a 37 amino-acid neuropeptide that plays a critical role in the pathogenesis of migraine. CGRP receptor antagonist, also known as gepant, is an oral medication that inhibits the CGRP-related nociceptive signaling pathway. To date, three gepants are approved by the FDA for migraine treatment. Atogepant is a 2nd-generation gepant that non-competitively antagonizes CGRP receptors inhibiting neurogenic inflammation and pain sensitization. With its long half-life and minimal cardiovascular or liver toxicity, it is the first in its class approved primarily for migraine prevention. This article …

Impact Of Age And Social Distancing On Covid-19 Epidemic In India, Harish Kumar, Sini V. Pillai, Vipin H

Management Dynamics

Corona virus disease 2019 (COVID-19) is an infectious disease with Acute Intense Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), and the World Health Organization (WHO) has proclaimed Covid-19 as a pandemic. The virus can spread quickly through close contact and via respiratory droplets induced when people cough or sneeze. The respective officials have promoted social Distancing, and governing bodies as a precautionary measure to prevent this novel disease as social contacts between people have a solid assortative structure in age. A mathematical model is used to predict the transmission of the disease, including age and social contact structure. In the research …

The Patentability Of Inventions With Artificial Intelligence Listed As An Inventor Following Thaler V. Hirshfeld, Kaitlyn Taylor

The University of Cincinnati Intellectual Property and Computer Law Journal

No abstract provided.

*That’S Just The Way I Am: Conscientiousness, Neuroticism, State-Trait Anxiety, And High-Pressure Exam Grades, Renee Hanson

Campus Research Month

The purpose of this study is to describe the relationship between undergraduate students’ personality traits (conscientiousness and neuroticism), their anxiety before a high-pressure exam (state-trait anxiety scores), and their grade on that exam.

2c Patent Law Session. U.S. Patent Developments, Martin J. Adelman, Nicholas P. Groombridge, Laura Sheridan, Carey R. Ramos, Marjan Noor, Nahoko Ono

29th Annual Intellectual Property Law & Policy Conference (2022)

No abstract provided.

Multi-Scale Computer Modeling For Advanced Pharmaceutical Manufacturing, Bodhi Chaudhuri

Amgen Seminar Series in Chemical Engineering

Drug development and manufacturing are one of the significant processes in the pharmaceutical industry. Various computational methods have been dramatically reducing the time and cost of drug discovery and development. Improved algorithms, overgrowing powerful computing architectures and the accelerating growth of rich data sets are driving advances in multiscale modelling methods capable of bridging chemical and biological complexity from the atom to the manufacturing scale. In this talk, the roles of physics based multiscale modeling and simulations in the areas of (i) continuous manufacturing of complex dosage forms and (ii) electrostatic behavior of pharmaceutical powders will be discussed. These research …

Book Reviews, Florida Historical Society

Florida Historical Quarterly

Greene et al. eds., Money, Trade, and Power: The Evolution of South Carolina's Plantation Society, by Randall Miller; Early American Indian Documents: Treaties and Laws, 1607-1789, Volume XII: Georgia and Florida Treaties, 1763-1776, by Greg O'Brien; Gordon, South Carolina and the American Revolution: A Battlefield History, by Greg Massey; O'Brien, Choctaws in a Revolutionary Age, 1750-1830, by Joel Martin; Engs and Miller, eds., The Birth of the Grand Old Party: The Republicans' First Generation, by Stephen D. Engle; Gallagher, ed., The Shenandoah Valley Campaign of 1862, by Chris Meyers; Baggett, The Scalawags: Southern Dissenters in the Civil War and Reconstruction, …

Reconstructing The Confederate Widow: An Analysis Of The Wives Of Fallen Confederate Soldiers And Their Response To Reconstruction And The Post War Era, Christian Beasley

Campus Research Month

This study provides an analysis of how the post-civil war era and Reconstruction affected the financial, social, and political lives of the wives of fallen Confederate soldiers. Because men were the head of families and traditional breadwinners in the South, the widows of the 258,000 fallen Confederate soldiers had to reintegrate themselves into society and support their families without the assistance and comfort of a husband. Although this integration may seem straightforward, these widows struggled to overcome the economic and social difficulties laid before them, including the patriarchal traditions, mourning expectations, severe droughts, and unemployment that plagued these women. This …

Relationships Between Sleep Habits, Anxiety, And Academic Performance In College Students, Keanne Fisher

Campus Research Month

This paper attempts to examine the correlation between sleep habits, anxiety, and academic performance.

Interspecific Pollen Transfer, Gene Flow, And Speciation In Bat-Pollinated Burmeistera H. Karst. & Triana (Campanulaceae: Lobelioideae), Juan Moreira-Hernandez

Dissertations

The evolutionary success of angiosperms has been largely influenced by their interactions with animal pollinators, which provide pollen and gene transport between individuals, populations, and young diverging species. Here, I examine the interplay between interspecific pollen transfer (IPT) by shared pollinators, gene flow, and the evolution of reproductive isolation in the young rapid radiation of Neotropical bat-pollinated bellflowers in the genus Burmeistera (Campanulaeae: Lobelioideae). In Chapter 1, I conducted an extensive review of the pollination and plant speciation literature to highlight the evolutionary consequences of IPT in angiosperms and showed that it has profound consequences for the evolution of floral …

The Identification Of Writer In Creating Gender Discourse In Feminist Writers’ Works, Aziza Zoirova, Nailya Bagautdinova

Scientific reports of Bukhara State University

Introduction. This paper aims to provide a comparative analysis of the French feminist writer Adiba Georges Sand's novel " Indiana" and its translation into Uzbek through a gynecological approach. The feminist research has addressed the concerns explored therein, namely gender discourse, instances of gender asymmetry, female and male discourse, and work focusing on the creation of feminitiatives in the original and translated language. Research methods.In this paper, the most basic methods used that lead to research on feminist-oriented writings such as the gynocratic method, comparative analysis, and encyclopedic methods. Gynocratic analysis was productively applied in identifying the skills, evaluations, and …