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New Species, Synonymy, New Records, And Taxonomic Notes In American Cerambycidae (Coleoptera), Juan Pablo Botero, Antonio Santos-Silva

Insecta Mundi

Cotyclytus parumnotatus (Zajciw, 1963) (Coleoptera: Cerambycidae: Cerambycinae: Clytini) is revalidated and a neotype is designated. Anatinomma Bates, 1892 (Cerambycinae: Hesperophanini) is reported as a neuter gender and two species-group names are corrected: A. brevicorne Fisher, 1944 and A. in­sulare Chemsak and Linsley, 1964; the latter is newly recorded from Honduras. Pachymerola vitticollis Bates, 1892 (Cerambycinae: Hyboderini) is recorded for the first time in the Mexican state of Jalisco, and chromatic variation is reported. Smodicum dinellii Bruch, 1911 (Cerambycinae: Smodicini) is recorded from Bolivia; and Corcovado bezarki Martins and Galileo, 2008 (Lamiinae: Hemilophini) is recorded from Belize. Parhip­popsis …

Volume Cxli, Number 20, April 29, 2022, Lawrence University

The Lawrentian

No abstract provided.

Evaluating The Microbial Quality And Use Of Antimicrobials In Raw Pet Foods, Leslie Pearl Cancio

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Raw meat-based diets (RMBDs) are emerging pet foods that pose food safety risks because of the potential presence of pathogens that could cause illness to humans. In this research, the microbial quality of select RMBD products sold by pet food companies online and the use of chemical antimicrobials to reduce the microbial load in chicken liver, a common RMBD ingredient, were evaluated.

Ground meat blends and livers from four animal species (beef, pork, chicken, turkey) were purchased from four online companies that delivers directly to consumers through parcel businesses. Products were procured at three different times during one year and …

Aktivitas Antioksidan Dan Sitotoksik Terhadap Sel Kanker Hela Dari Ekstrak Daun Vernonia Amygdalina (Asteraceae), Shabarni Gaffar, Muhammad Yudha Nugraha, Ersanda Hafiz, Hesti Lina Wiraswati, Tati Herlina

Chimica et Natura Acta

Vernonia amygdalina atau dikenal sebagai daun afrika merupakan salah satu tanaman obat yang berpotensi untuk dikembangkan sebagai nutraceutical, seperti antidiabetes, antimalaria dan antikanker. Penelitian ini bertujuan menentukan aktivitas antioksidan dan aktivitas sitotoksik ekstrak daun V. amygdalina terhadap sel kanker serviks HeLa, serta menentukan kelompok senyawa yang terdapat dalam ekstrak daun V. amygdalina dengan aktivitas sitotoksik dan antioksidan tertinggi melalui penapisan fitokimia. Metode yang digunakan pada penelitian ini adalah ekstraksi dan fraksinasi menggunakan pelarut metanol, etil asetat, dan n-hexana. Semua fraksi diuji aktivitas antioksidannya menggunakan metoda DPPH dan aktivitas sitotoksiknya terhadap sel kanker serviks HeLa menggunakan metode MTS, serta penapisan fitokimia …

Green Synthesis Nanopartikel Perak Dengan Bioreduktor Ekstrak Daun Rami (Boehmeria Nivea) Melalui Iradiasi Microwave, Victor Handoko, Afina Yusradinan, Annas Nursyahid, Ayu Wandira, Asri Peni Wulandari

Chimica et Natura Acta

Nanopartikel perak dikategorikan sebagai material antibakteri karena kemampuannya merusak integritas membran sel bakteri. Terdapat berbagai metode untuk menyintesis nanopartikel perak, salah satunya adalah dengan pendekatan green synthesis menggunakan bioreduktor ekstrak tanaman. Daun rami (Boehmeria nivea) mengandung senyawa aktif yang bersifat antibakteri dan antiviral seperti etil palmitat, 1-(4-bromobutil)-2-piperidinon, dan α-metil linoleat. Selain itu ekstrak daun rami berpotensi mereduksi ion perak menjadi nanopartikel perak karena mengandung senyawa dietilen glikol, asam miristoleat dan tetradeka-13-en-11-un-1-ol. Proses reduksi ion perak dapat dioptimalkan dengan iradiasi microwave melalui pemanasan yang seragam dan cepat. Penelitian ini bertujuan untuk melakukan green synthesis dan karakterisasi nanopartikel perak dengan ekstrak daun …

Interactions Among Endothelial Nitric Oxide Synthase, Cardiovascular System, And Nociception During Physiological And Pathophysiological States, Niribili Sarmah, Andromeda M. Nauli, Ahmmed Ally, Surya M. Nauli

Pharmacy Faculty Articles and Research

Nitric oxide synthase (NOS) plays important roles within the cardiovascular system in physiological states as well as in pathophysiologic and specific cardiovascular (CV) disease states, such as hypertension (HTN), arteriosclerosis, and cerebrovascular accidents. This review discusses the roles of the endothelial NOS (eNOS) and its effect on cardiovascular responses that are induced by nociceptive stimuli. The roles of eNOS enzyme in modulating CV functions while experiencing pain will be discussed. Nociception, otherwise known as the subjective experience of pain through sensory receptors, termed “nociceptors”, can be stimulated by various external or internal stimuli. In turn, events of various cascade pathways …

The Effects Of Twitter Posts Regarding Covid-19 Information On The Viewer’S Perception Of Credibility: A Study On Misinformation, Grace T. Long

Honors Theses

In the current age, social media plays a large role in daily life. Although there have been massive advancements through social media, there have also been disadvantages due to its prominence. One such disadvantage is the dissemination of misinformation through social media platforms, especially during the COVID-19 pandemic. There are many aspects affecting the social media posts we find credible. This study investigated the different evaluations of COVID-19 credibility ratings in groups with varying political affiliations (conservative and liberal) and primary news sources (social media and newspaper). Misinformative posts along with true posts were used to garner credibility ratings and …

The Role Of Free Radicals In The Activation Of Epidermal Growth Factor Receptors In Murine Microglial Cells, Eliana John

Honors Theses

Regulation of cellular processes is important for proper functioning. Environmental factors, including stress, can interfere with cellular regulation. One of the diseases caused by cellular regulation disturbance is cancer and mutations in EGF-related genes highly correlate with worse outcomes in cancer. The Epidermal Growth Factor (EGF) pathway is involved in the regulation of cell growth and differentiation. Phosphorylation of the receptors activates this pathway, leading to cell growth and regulation. This study examines the impact of oxidative stress on EGF pathway activation. Previous studies using breast cancer lines have indirectly shown a decrease in Epidermal Growth Factor Receptor (EGFR) activation …

An Integrated Network Representation Of Multiple Cancer-Specific Data For Graph-Based Machine Learning, L M. Pu, M Singha, H C. Wu, C Busch, L M. Pu, M Brylinski

Faculty Publications

Genomic profiles of cancer cells provide valuable information on genetic alterations in cancer. Several recent studies employed these data to predict the response of cancer cell lines to drug treatment. Nonetheless, due to the multifactorial phenotypes and intricate mechanisms of cancer, the accurate prediction of the effect of pharmacotherapy on a specific cell line based on the genetic information alone is problematic. Emphasizing on the system-level complexity of cancer, we devised a procedure to integrate multiple heterogeneous data, including biological networks, genomics, inhibitor profiling, and gene-disease associations, into a unified graph structure. In order to construct compact, yet information-rich cancer-specific …

Conducting Neonatal Intensive Care Unit Research During A Pandemic: Challenges And Lessons Learned, Marliese Dion Nist, Sharon G. Casavant, Robin B. Dail Phd, Rn, Faan, Kayla C. Everhart Phd, Rn, Stephanie Sealschott, Xiaomei S. Cong

Publications

Background The coronavirus pandemic disrupted normal clinical operations and research. Nurse scientists conducting research studies in the neonatal intensive care unit experienced significant challenges to continuing their research studies amid national lockdowns and hospital visitation restrictions. Objectives The purpose of this article is to describe the challenges encountered by nurse scientists conducting research studies in the neonatal intensive care unit during the pandemic, the creative solutions devised to overcome these barriers, and the lessons learned during this unprecedented time. Methods Using our pandemic area studies as exemplars, we highlight the barriers encountered in continuing our research in the intense environment …

Genetic Effects In Response To Extremes In Precipitation In Arabidopsis Thaliana, Marilyn Ives, Simranjit Kaur, Sydney Martens

Symposium on Research and Creative Expression (SORCE)

Climate change impacts the environment of the Midwestern United States, leading to an unpredictability in rainfall. The precipitation pattern now common to the Midwest region is extremely wet springs and dry summers. This irregularity of precipitation may cause issues with plant growth. In this experiment, we research the effect irregular watering has on the growth of 100 different Arabidopsis thaliana recombinant inbred lines (RIL). They were obtained from the Arabidopsis Biological Resource Center at the Ohio State University and were bred from a cross of Ler (Landsberg erecta) x Col (Columbia). The phenotypes that we will measure are time to …

Communicating Human-Object Orientation: Rhetorical Strategies For Countering Multiple Taboos, Kristen L. Cole

Faculty Research, Scholarly, and Creative Activity

The Objectùm-Sexuality Internationale (OSI) website is the largest source of information representing a community who experiences emotional and romantic desire towards objects. This chapter presents a queer rhetorical analysis of OSI to understand how queer communities that must negotiate multiple taboos (en)counter the public. The author argues that OSI reveals two things about taboo communication: 1) the discursive and material boundaries that constitute the taboo and 2) the rhetorical work required to disrupt these boundaries. The author's analysis reveals how OSI engages in complex rhetorical practices to lay the groundwork for a queer-posthuman counterpublic-a rhetorical space that disrupts the heteronormative …

Strengthening Executive Function And Self-Regulation In Early Childhood Classroom, Molly Grosvenor

Masters Projects

Executive function (EF) is an umbrella term used to describe the group of higher order thinking and regulatory processes. They are the brain functions that enable working memory, inhibitory control, and attentional or mental flexibility and there are many factors that impact the early development. Research confirms that EF skills are malleable and can be improved through preschool experiences. Early support and intervention are especially important for children who enter school with poorer executive function skills and are at risk because of social, economic, or other adverse childhood experiences. This project aims to provide a workshop and training handbook for …

Design, Synthesis, And Analysis Of Paired Coiled-Coil Peptidic Molecular Building Blocks Used For Linearly Controlled Self-Assembly Of Α-Helical Coiled-Coil Heterodimer Peptide Pairs, Jason Distefano

Chemistry Theses

Molecular building blocks are fundamental to biological synthesis and processes and have been utilized in advanced materials, drugs and drug delivery systems, and biotechnology. Proteins have been used as molecular building blocks for the construction of complex, well-ordered structures. Coiled-coil protein domains are essential subunits used for the oligomerization of protein complexes, gene expression, and structural elements of biological materials. The synthesis and assembly of proteins utilizing coiled-coil motifs are of great scientific interest due to their potential applications in disease treatment, biomechanical motors, nanoscale delivery systems, etc. However, assembling protein complexes with specific morphology is still challenging because …

Examining Social Determinants Of Health During A Pandemic: Clinical Application Of Z Codes Before And During Covid-19, Xueying Yang Ph.D., Brooks Yelton, Shujie Chen, Jiajia Zhang Ph.D., Bankole Olatosi Ph.D., Shan Qiao Ph.D., Xiaoming Li Ph.D., Daniela B. Friedman Ph.D.

Faculty Publications

Recognition of the impact of social determinants of health (SDoH) on healthcare outcomes, healthcare service utilization, and population health has prompted a global shift in focus to patient social needs and lived experiences in assessment and treatment. The International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) provides a list of non-billable “Z codes” specific to SDoH for use in electronic health records. Using population-level analysis, this study aims to examine clinical application of Z codes in South Carolina before and during the COVID-19 pandemic. The study population consists of South Carolina residents who had a healthcare visit and had …

The Deep-Pelagic Sergestid Shrimp Assemblage In The Gulf Of Mexico In The Vicinity Of The Deepwater Horizon Oil Spill, Erik W. Hine

All HCAS Student Capstones, Theses, and Dissertations

This thesis focuses on the geographical (near-slope vs. offshore) and temporal analyses (2011 – 2018) of the Sergestidae assemblage, the crustacean family with the fourth highest total biomass, in the Gulf of Mexico near the location of the Deepwater Horizon oil spill. The abundance and biomass of the assemblage were analyzed to determine if statistical differences were present between the near-slope and offshore environments. In addition, this study analyzed the vertical distributions of sergestid species in the epipelagic, mesopelagic, and bathypelagic zones to determine the extent of the migratory behavior of these species. Lastly, the abundance and biomass in the …

The Microbiome Characterization And Comparison Of Loggerhead (Caretta Caretta) And Green (Chelonia Mydas) Sea Turtle Eggs In Broward County, Florida, Colleen Mcmaken

All HCAS Student Capstones, Theses, and Dissertations

All seven extant species of sea turtles are classified as threatened or endangered due to natural and anthropogenic impacts. Sea turtle conservation efforts are largely dedicated to ensuring healthy nesting activity. Hatching success of sea turtle eggs can be affected by several factors including the proliferation of pathogenic microbes. However, it is unclear as to which microbes have the most impact on hatching success and how they are transmitted into the eggs. The primary aims of this study characterized and compared the bacterial communities (microbiomes) from the i) cloaca of nesting sea turtles; ii) sand within and surrounding the nests …

Unearthing The Witch: Reckoning With Gender, Magic, And The Unusual Dead Within Anglo-Saxon Deviant Burials, Samantha Melvin

Departmental Honors & Graduate Capstone Projects

The fifth to seventh centuries CE, or the Migration Period, marked the development of Anglo-Saxon culture and society in England. The early Anglo-Saxons are known largely through their material culture and mortuary practices, left behind in medieval cemeteries that twist their way across the English landscape. The remains of early Anglo-Saxons tell rich and interesting histories about past peoples, but within the broader landscapes of these cemeteries are deviant burials. These are burials that are specifically typified as ones that ‘deviate’ from the norm, usually indicating that the inhumed individual was punished in death for actions committed in life. These …

Light Acupuncture And Five-Element Music Therapy For Nurses' Mental Health And Well-Being During And Post-Covid-19: Protocol For A Randomised Cross-Over Feasibility Study, Carol Chunfeng Wang, Johnny Lo, Rosemary Saunders, Esther Adama, Caroline Bulsara, Christopher Etherton-Beer, Angela Wei Hong Yang

Research outputs 2022 to 2026

INTRODUCTION: Australian nurses have experienced higher levels of anxiety during the COVID-19 pandemic compared with the prepandemic. This may have affected their long-term mental health and intention to stay in the profession resulting in a workforce shortage, which further impacts the health of the public. Management is urgently required to improve nurses' well-being. However, there is limited evidence available. The proposed clinical trial aims to evaluate the feasibility and therapeutic effects of using a combination of light acupuncture and five-element music therapy to improve nurses' mental health and well-being during and post-COVID-19. METHODS AND ANALYSIS: This randomised, single blinding, two-arm …

Conversations In Cochlear Implantation: The Inner Ear Therapy Of Today, Grant Rauterkus, Anne K. Maxwell, Jacob B. Kahane, Jennifer J. Lentz, Moises A. Arriaga

School of Medicine Faculty Publications

As biomolecular approaches for hearing restoration in profound sensorineural hearing loss evolve, they will be applied in conjunction with or instead of cochlear implants. An understanding of the current state-of-the-art of this technology, including its advantages, disadvantages, and its potential for delivering and interacting with biomolecular hearing restoration approaches, is helpful for designing modern hearing-restoration strategies. Cochlear implants (CI) have evolved over the last four decades to restore hearing more effectively, in more people, with diverse indications. This evolution has been driven by advances in technology, surgery, and healthcare delivery. Here, we offer a practical treatise on the state of …

Editorial: Mucosal Vaccination: Strategies To Induce And Evaluate Mucosal Immunity, Pamela A. Kozlowski, Nicholas J. Mantis, Andreas Frey

School of Medicine Faculty Publications

No abstract provided.

Assessing The Efficacy Of Cites Restrictions On Malagasy Rosewood, Nicholas Cargill

Honors Theses

This paper seeks to determine whether the CITES trade restrictions on rosewood have been effective. Effectiveness will be measured by the amount of illegal logging the restrictions reduce. The Matt Hansen Global Deforestation dataset, which measures deforestation from year to year, will be analyzed in the Google Earth Engine Code Editor to determine the yearly amount of deforestation in Madagascar. This output will then be loaded into R and assessed using OLS estimation techniques to determine whether the ban had a significant impact on the amount of illegal logging occurring in Madagascar. Because CITES restrictions are lifted and restored with …

Analysis Of Test Anxiety In Human Anatomy And Physiology I Students At The University Of Mississippi, Anne Piazza

Honors Theses

Student anxiety, specifically test anxiety, is common hindrance to student performance in various courses including Human Anatomy and Physiology at the University of Mississippi. Through a sequence of three surveys we collected demographic information, anxiety data related to the course, and test anxiety in general We researched factors that could potentially influence student anxiety such as at what point in the semester the student is evaluated, when students feel the most stressed, outcomes on previous evaluations, and perceived outcomes of the course. We also examined what effect the anxiety has on the student such as lowered performance, lowered test scores, …

Assessment Of Manure Treatment Technology Adoption And Feedlot Runoff Monitoring Opportunities, Juan Carlos Ramos Tanchez

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Livestock products contain valuable nutrients that enhance human health, and their production generates positive local and national economic impacts. The livestock sector also deals with large quantities of environmentally important nutrients in manure. The purpose of this thesis is to further the aims of researchers and educators working at the intersection of livestock production and the environment to identify and promote best practices for livestock production and manure management that are economically and environmentally sustainable.

The second chapter explored options to evaluate nutrient flows in feedlot runoff at the pen scale. Pen scale monitoring is an important consideration for research …

Prenatal Exposure To A Climate-Related Disaster Results In Changes Of The Placental Transcriptome And Infant Temperament, Jessica Buthmann, Dennis Huang, Patrizia Casaccia, Sarah O'Neill, Yoko Nomura

Advanced Science Research Center

Maternal stress during pregnancy exerts long-term effects on the mental well-being of the offspring. However, the long-term effect of prenatal exposure on the offspring’s mental status is only partially understood. The placenta plays a vital role in connecting the maternal side to the fetus, thereby serving as an important interface between maternal exposure and fetal development. Here, we profiled the placental transcriptome of women who were pregnant during a hurricane (Superstorm Sandy), which struck New York City in 2012. The offspring were followed longitudinally and their temperament was assessed during the first 6–12 months of age. The data identified a …

Targeted Treatment For High-Risk Early-Stage Triple-Negative Breast Cancer: Spotlight On Pembrolizumab, Nusayba A Bagegni, Andrew A Davis, Katherine K Clifton, Foluso O Ademuyiwa

Open Access Publications

Triple-negative breast cancer (TNBC) is a biologically aggressive yet heterogeneous disease that disproportionately affects younger women and women of color compared to other breast cancer subtypes. The paucity of effective targeted therapies and the prevalence of chemotherapeutic resistance in high-risk, early-stage TNBC pose significant clinical challenges. Deeper insights into the genomic and immune landscape have revealed key features of TNBC, including intrinsic genomic instability, DNA repair deficiency, and potentially an immunogenic tumor microenvironment. These advances led to landmark trials with immune checkpoint inhibitors in the advanced-stage setting, which subsequently translated into immunotherapy-based clinical trials in the early-stage setting and recent …

Effects Of Feeding Probiotics To Pre-Weaned Dairy Calves, Sara Tomis

Honors Scholar Theses

Pre-ruminant calves are particularly susceptible to pathological and environmental stressors that may have negative effects on their health and growth. Supplementing probiotics to this vulnerable population may have positive implications for the dairy industry, as probiotics may encourage improved growth rates and enhanced health in dairy neonates. However, there is variation in existing literature with regard to effectiveness. This study seeks to explore the impact of dietary probiotic supplement on health and growth parameters in pre-weaned dairy calves. Holstein and Jersey calves (n=30) were assigned to 1 of 2 treatment groups, receiving either 0 or 5 grams of probiotic containing …

Efficacy And Safety Of Larotrectinib In Patients With Trk Fusion-Positive Thyroid Carcinoma, Steven G Waguespack, Alexander Drilon, Jessica J Lin, Marcia S Brose, Ray Mcdermott, Mohammed Almubarak, Jessica Bauman, Michela Casanova, Anuradha Krishnamurthy, Shivaani Kummar, Serge Leyvraz, Do-Youn Oh, Keunchil Park, Davendra Sohal, Eric Sherman, Ricarda Norenberg, Josh D Silvertown, Nicoletta Brega, David S Hong, Maria E Cabanillas

Kimmel Cancer Center Faculty Papers

Objective: Larotrectinib is a highly selective tropomyosin receptor kinase (TRK) inhibitor with demonstrated efficacy across various TRK fusion-positive solid tumours. We assessed the efficacy and safety of larotrectinib in patients with TRK fusion-positive thyroid carcinoma (TC).

Methods: We pooled data from three phase I/II larotrectinib clinical trials (NCT02576431, NCT02122913, and NCT02637687). The primary endpoint was the investigator-assessed objective response rate (ORR) per Response Evaluation Criteria in Solid Tumors v1.1. Secondary endpoints included duration of response (DoR), progression-free survival (PFS), overall survival (OS), and safety. Data cut-off: July 2020.

Results: Twenty-nine patients (median age: 60; range: 6-80) …

Bumpy Stem Is An Arabidopsis Choline/Ethanolamine Kinase Required For Normal Development And Chilling Responses, Christina Rabeler, M. Chen, Nicholas J. Kaplinsky

Biology Faculty Works

Phospholipid biosynthesis is a core metabolic pathway that affects all aspects of plant growth and development. One of the earliest step in this pathway is mediated by choline/ethanolamine kinases (CEKs), enzymes in the Kennedy pathway that catalyze the synthesis of the polar head groups found on the most abundant plant phospholipids. The Arabidopsis genome encodes four CEKs. CEK1-3 have been well characterized using viable mutants while CEK4 encodes an essential gene, making it difficult to characterize its effects on plant development and responses to the environment. We have isolated an EMS-induced allele of CEK4 called bumpy stem (bst …

Spring Choral Concert 2022, St. Norbert College Music Department

Music Performances

The St. Norbert College Music Department presents: Spring Choral Concert & Senior Tribute, featuring the St. Norbert College Concert Choir & Chamber Singers.