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Density Functional Theory Studies Of Fermi Resonance In Small Aryl Azide Vibrational Probes, Gammanage Sathya Madhuwanthi Perera

Theses

Site-specific study of the protein using time-resolved IR spectroscopy with the assistance of vibrational probes (VPs) has been the most promising research discipline. However, azide VPs that are absorbed within the protein transparent window generate a complex absorption profile due to Fermi resonance (FR). In the current study, the azide absorption profiles of three aryl-azide compounds: 4-azidotoluene, 4-azido-N-phenylmaleimide, and 4-azidoacetanilide have been explored with basis set effect, solvent effect, intramolecular effect, and the effect of rotational isomerism. Basis set effect was studied using seven basis sets namely: 6-31G(d,p), 6-31+G(d,p), 6-31++G(d,p), 6-311G(d,p), 6-311+G(d,p), 6-311++G(d,p) and 6-311++G(df,pd) with DFT/B3LYP. Geometry optimization and …

An Inquiry Into The Language Development Of Twins: An Autoethnographic Study, Madison Grimm

Undergraduate Honors Theses

According to research, many twins have some form of a language delay. Despite the considerable research on twin language, the cause of these language delays is unknown. Several of the factors that have been proposed include genetics, prematurity, and low birth weight. I am a twin, and through this research, I reflect on my own language development from both memory and the records my family kept. The data from the records indicate that, unlike many other twins, I did not have a language delay. Despite the lack of a language delay, the data indicates the possibility that the environment and …

The Influence Of Violence, Policing, And Substance Use Stigma On Sexual And Substance Use Risk Engagement In Substance Using Men Along The U.S.-Mexico Border, William Campillo Terrazas

Open Access Theses & Dissertations

Background: Cities along the U.S.-Mexico border are unique environments where structural level variables place residents at risk for increased substance use subsequently impacting HIV rates and acquisition. Growing evidence emphasizes the importance of understanding how structural drivers of infectious diseases impact community and social networks to develop interventions to reduce HIV transmission among hard-to-reach populations.

Aims and Objectives: The goal of this study was to investigate the influence of structural factors such as neighborhood disruption, harsh policing, and substance use stigma on engagement of HIV risk behaviors among social networks of people who use drugs and who reside in El …

Nanotechnology-Based Approaches To Mitigate Environmental Pollutants -- Induced Neurological Disorders, Jyoti Ahlawat

Open Access Theses & Dissertations

Neurodegenerative diseases such as Parkinson's disease (PD), Alzheimerâ??s Disease (AD) and Huntingtonâ??s Disease (HD) have no cure despite intensive research efforts geared towards therapeutics development. In the USA, patients with PD and AD alone cost the nation ~ $200 billion annually in patient care and lost productivity. Therefore, there remains an urgent and unmet need to develop novel drugs and drug carriers with the potential to slow down, halt and ideally reverse the course of neurodegenerative disorders. The dissertation focuses on developing approaches towards targeting PD using multifactorial mechanisms including the targeting of protein aggregation and oxidative stress. This is …

Regulation Of C-C Chemokine Receptor 7 (Ccr7) Ligand-Mediated Internalization And Chemotaxis By G Protein-Coupled Receptor Kinase Family 4 (Grk-4, 5, 6) In Human Pediatric T-Cell Acute Lymphoblastic Leukemia (T-All), Eduardo Elias Chaib

Open Access Theses & Dissertations

Background and Significance: The Hispanic population is disproportionally affected by T-ALL (T-cell acute lymphoblastic leukemia) when compared to other races in the US. C-C Chemokine Receptor 7 (CCR7) in T-ALL is used during disease progression, and may lead to migration of cancerous cells into the Central Nervous System (CNS) of patients. Goals and Objectives: This project aims to find relevant rates and risk factors for T-ALL for the Hispanic population in the US/Mexico border region. The other aim is to assess the effect of the G protein-coupled Receptor Kinase 4 (GRK-4) family proteins on migration and receptor internalization through CCR7 …

The Protective Influence Of Mindfulness Facets On The Relationship Between Negative Core Beliefs And Social Media Addiction Among Latinx College Students, Mariany Gainza Perez

Open Access Theses & Dissertations

Social media use has continued to rise over the last decade. This behavioral addiction shares essential components with substance addictions (e.g., mood modification, withdrawal). Dysfunctional core beliefs have recently been investigated in relation to Internet addiction and problematic Facebook use, but not with social media addiction specifically. Similarly, mindfulness-based interventions have been developed for various types of technology-related behavioral addictions, yet the relationship between dispositional mindfulness and social media addiction remains unexplored. This study investigated the relationships between these constructs among Latinx undergraduates within the context of social cognitive theory. Participants (n=386; 80.3% female) completed an online survey that assessed …

Small Heat Shock Protein 27 And Its Role In Human Disease, Bianka Andrea Holguin

Open Access Theses & Dissertations

Small heat shock protein 27 (Hsp27) is a ubiquitously expressed molecular chaperone with roles in many physiological processes. As an ATP-independent molecular chaperone, Hsp27 protects substrates from irreversible aggregation and holds them in a folding competent state for later recycling into the proteome. Hsp27 proteins form dimers that are assembled into large oligomeric complexes. Phosphorylation of Hsp27 dissembles the oligomers into chaperone active dimers. Several missense mutations of Hsp27 are causative for the neurodegenerative disorders Charcot-Marie-Tooth disease 2F and distal Hereditary Motor Neuropathy IIB. Here I show that the oligomerization and chaperoning ability of Hsp27 are altered by the Hsp27 …

The Electrostatic Features Of Dengue Virus Capsid Assembly, Alan Eduardo Lopez Hernandez

Open Access Theses & Dissertations

Dengue virus causes serious diseases and considerable deaths each year all around the globe. Dengue virus undergoes assembly in a capsid, matures and becomes viral. Revealing mechanisms of the viral capsid protein may lead to the discovery of novel drugs that prevent this assembly to happen and stop the virus from spreading. Here I present a computational work which is focused on the stability and assembly of the dengue viral capsid. The E and M proteins conform a heterotetramer, which consists of two copies of E and M proteins. The heterotetramers form a highly ordered capsid. In the electrostatic analysis …

Self-Determination Theory And Attachment Theory: An Integrative Model To Predict Drinking Motives And Protective Behavioral Strategies In Emerging Adults, Claudia Iliana Lopez

Open Access Theses & Dissertations

The integration of attachment theory and self-determination theory can be used to develop a statistical model to understand the association between attachment styles and basic psychological needs with drinking motives and protective behavioral strategies among emerging adults. Data collected from Prolific and UTEP (N = 437) was used in the present study to explore this possibility by examining the association between the variables of interest using linear regressions, SEM models, and moderated mediation models. Linear regressions demonstrated a statistically significant relationship between attachment styles, basic psychological needs, drinking motives and protective behavioral strategies. Although the complete and deconstructed SEM models …

The Role Of Map Kinase Phosphatase-5 In Cardiac Adaptations To Endurance Exercise, Jaime Alfredo Perales

Open Access Theses & Dissertations

Endurance Exercise is a form of exercise that provides many benefits to the human body. Primarily, the cardiac muscle endures many cardiac adaptations in response to Endurance Exercise. But the mechanisms that are involved within these adaptations remains to be fully understood. MAPK or mitogen-activated protein kinase is a well know signaling pathway that promotes many cardiac benefits such as cell proliferation, protein synthesis and cell differentiation. Although this pathway is activated due to its upstream kinase (MKKs), the research presented focuses on the relationship and mechanisms involved in mitogen kinase phosphatase (MKPs) specifically (MKP-5). The research presented hopes to …

The Shaping Of Ethnic Mexican Identity In The Segregated Schools Of Presidio, County, Texas, 1867-1947, Aurelio Saldana

Open Access Theses & Dissertations

The work conducts a sociological analysis of the historical record documenting segregated school settings in a rural area from 1867 to 1947 using socialization theory. The sociological theory of schemas will provide a lens from the Americanization process students in the U.S., specifically ethnic Mexican students, underwent to shape "American" identity. The analysis ventures into the intersectionality created by the social constructs of gender, sex, race, and class and how these factors combined as part of the Americanized socialization of ethnic Mexican students. Gender inequality, or patriarchy, was a leading factor in shaping the contested U.S.-Mexico borderlands and U.S. society. …

Rethinking Metaphor In The Rhetoric Of Alzheimer's Disease, Evelyn Saru Jimmy

Open Access Theses & Dissertations

This dissertation examines the metaphors that early onset Alzheimer's blog authors use to make meaning of their experiences living with Alzheimer's disease (AD). To complicate the study, I also compare whether early onset Alzheimer's blog authors use the same metaphors with those who serve as caregiver to late-stage AD patients. This research project is situated within the overlap fields of Disability Studies (Dolmage, 2006; Lewiecki-Welson, 2003; Yergeau, 2014; Kerschbaum, 2014), Rhetoric of Health and Medicine (Segal, 1997: Price, 2011; Molloy, 2015) Rhetoric of Mental Health (Chrisman, 2008; Uttapha, 2017, Reynold, 2008), and Technical Communication (Meloncon, 2014). Following the principles of …

Covid Synergy: A Machine Learning Approach Uncovering Potential Treatment Combinations For Sars-Cov-2, Jason Eden Sanchez

Open Access Theses & Dissertations

For more than two years, the COVID-19 pandemic has upended the lives of billions of individualsworldwide leading to disruptions in healthcare, the economy and society at large. As the pandemic enters its third year, the human impact cannot be overstated and the need to develop effective pharmaceuticals remains. Though there currently exits FDA-approved medications for COVID-19, the emergence of novel variants, such as Omicron, highlights the importance of discovering new therapies which will continue to be effective regardless of the pandemicâ??s progression. Because discovering new medications is a costly and timeintensive endeavor, my approach entails drug repurposing to test medications …

Understanding The Role Of Small Mammals In Arctic Biogeochemical Cycling, Austin Roy

Open Access Theses & Dissertations

Small mammals play an integral role in their ecosystems. This is especially true in northern ecosystems, where small mammals represent both top-down and bottom-up forces and can have strong effects on ecosystem function through affecting biogeochemical cycling. Despite these important effects, the role of small mammals in influencing biogeochemical cycling has been largely underappreciated in the understanding of arctic ecosystems, leading to a call to better understand how small mammal herbivores impact ecosystem processes including carbon cycling. The overarching goal of this dissertation is to assess how biogeochemical cycling is affected by small mammal herbivore presence, behavior, and population dynamics …

Race, Science, And The Language Of Drug Control In The Americas, 1870s - 1920s, Freddy Mauricio Jaimes Jaimes

Open Access Theses & Dissertations

This dissertation explores the origins of the language of drug addiction and drug control in the American hemisphere during the late nineteenth and early twentieth centuries by analyzing the intersection between the scientific study of race and eugenics and the cultural and political reaction to the Chinese global diaspora across the Pacific. I argue that Chinese immigrants perfectly embodied European "scientific" ideas of national or racial degeneration in the minds of scientific and medical elites while exemplifying the publicâ??s predominant stereotypes of addiction. Chinese immigrants became the first and perhaps most powerful symbol that intrinsically associated drug consumption with degeneracy. …

Winners And Losers In Dryland Reforestation: Species Survival, Growth, And Recruitment Along A 33-Year Planting Chronosequence, Clifton Albrecht, Zarek Contreras, Kimberly Wahl-Villarreal, Mitch Sternberg, Bradley O. Christoffersen

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Reforestation in the Lower Rio Grande Valley (LRGV) of Texas began in the 1960s and to date over 6,475 ha of land has been reforested. However, there has been minimal assessment to understand differential species success, compositional trends, and the aboveground C sequestration potential of these developing forests. We coupled quantitative planting information of >50 native woody tree and shrub species with surveys of 5,223 stems of 4,606 individuals in a chronosequence of restored forests ranging in age from 1 to 33 years to estimate species-specific mortality rates, biomass accumulation and recruitment, as well as compositional trends in the herbaceous …

Evolved Resistance To A Novel Cationic Peptide Antibiotic Requires High Mutation Supply, Alfonso Santos-Lopez, Melissa J. Fritz, Jeffrey B. Lombardo, Ansen H.P. Burr, Victoria A. Heinrich, Christopher Marshall, Vaughn S. Cooper

Biological Sciences Faculty Research and Publications

Background and Objectives

A key strategy for resolving the antibiotic resistance crisis is the development of new drugs with antimicrobial properties. The engineered cationic antimicrobial peptide WLBU2 (also known as PLG0206) is a promising broad-spectrum antimicrobial compound that has completed Phase I clinical studies. It has activity against Gram-negative and Gram-positive bacteria including infections associated with biofilm. No definitive mechanisms of resistance to WLBU2 have been identified.

Methodology

Here, we used experimental evolution under different levels of mutation supply and whole genome sequencing (WGS) to detect the genetic pathways and probable mechanisms of resistance to this peptide. We propagated populations …

Chromosome-Level Genome Assembly Reveals Dynamic Sex Chromosomes In Neotropical Leaf-Litter Geckos (Sphaerodactylidae: Sphaerodactylus), Brendan J. Pinto, Shannon E. Keating, Stuart V. Nielsen, Daniel P. Scantlebury, Juan D. Daza, Tony Gamble

Biological Sciences Faculty Research and Publications

Sex determination is a critical element of successful vertebrate development, suggesting that sex chromosome systems might be evolutionarily stable across lineages. For example, mammals and birds have maintained conserved sex chromosome systems over long evolutionary time periods. Other vertebrates, in contrast, have undergone frequent sex chromosome transitions, which is even more amazing considering we still know comparatively little across large swaths of their respective phylogenies. One reptile group in particular, the gecko lizards (infraorder Gekkota), shows an exceptional lability with regard to sex chromosome transitions and may possess the majority of transitions within squamates (lizards and snakes). However, detailed genomic …

Evaluation Of Accelerated Testing Methods To Predict The Effects Of Chemical Exposure On Mechanical Properties Of Polyester Composites In Municipal Wastewater Service, Roberto A. Garcia

Theses and Dissertations

Composite Access Products (CAP) is a company that is determined to replace traditional steel manhole covers with fiber reinforced polymer alternatives that have similar performance while also introducing several advantages. CAP can achieve this by manufacturing the polymer manhole covers using high-speed, high pressure compressing molding to produce lightweight, long-lasting, corrosive resistant covers. CAP’s composite covers have been approved for use by TXDOT in roadway zones. Despite this, they must now undergo more testing and verification for use in environments with highly corrosive elements such as sewage environments and waste processing plants. In these situations, the polymer manhole covers will …

Removal Of Arsenic (Iii) And Arsenic (V) From Aqueous Solution Via Common Sunflower Helianthus Annuus By Phytoremediation, Irving A. Vazquez Hurtado

Theses and Dissertations

Phytoremediation provides a cost-effective, non-invasive technique to remove contaminants from the soil and groundwater. Sunflowers are fast growing and have a showed effective at removing various pollutants from soil, including lead and other heavy metals. Health issues related to arsenic are mainly attributed to exposure of arsenite, whereas arsenate is much less toxic. The common sunflower Helianthus annuus was the species used to remove both arsenic (III) and As(V) ions from hydroponics solutions. In the present study sunflower seeds were germinated for a week, placed under the sun for a day and subsequently placed in a nutrient solution to aid …

Forecasting Salinity In The Laguna Madre Using Deep Learning, Martin J. Flores Jr.

Theses and Dissertations

Salinity is an important metric in the Laguna Madre for establishing the long term health of the local ecological population. By utilizing Deep Learning (DL) techniques, the predicted and forecasted salinity in the Laguna Madre is generated from data provided by the Moderate Resolution Imaging Spectroradiometer (MODIS)-Aqua satellite.

Currently, only one other DL model has been used to forecast Sea Surface Salinity (SSS), being a Recurrent Neural Network (RNN). However, the RNN model requires the prediction of a full area of salinity to function.

As such, several model architectures were tested, with the best one, being a Multi-input MPNN, utilized …

Assessing The Effects Of Levonorgestrel (Lng) On Neural Differentiation In The Developing Hypothalamus Using The Zebrafish (Danio Rerio) As A Model, Gabriella Hinojosa

Theses and Dissertations

Neurogenesis is a critical component of fetal neurodevelopment consisting of: migration, proliferation and differentiation. Health concerns from anxiety to reproductive issues have been linked to alterations of neurogenesis processes. Endocrine disrupting chemicals (EDCs) can mimic hormones vital to this process, potentially adversely affecting the susceptible fetal brain. One EDC, Levonorgestrel (LNG), is a testosterone-like progestin used in birth control methods that has a high bioavailability and long half-life. Using zebrafish embryos as a model, this lab previously discovered that an environmentally relevant LNG dose (5 ng/L) significantly increased anxiety behaviors. The hypothalamus is responsible for the development …

Corrido Of A Returning Angel: A Collection Of Stories, Ricardo Marez Jr.

Theses and Dissertations

As a Chicano (Mexican-American), person of color with a lower-middle class, American, South Texas upbringing, the world of authors and literature has always felt out of reach and not particularly inviting towards people like me—let alone representative or celebratory. In spite of this, or perhaps owing to it, I have decided to shoot my literary shot, unremittently holding onto my unique voice and unconventional styles in this first collection of short stories. I discuss in depth my inspirations and role models in writing, including Henry Miller and Whitman, with discussion of literary style and genre that include: surrealism, absurdism, allegory, …

Childhood Obesity Within The Lens Of Racism, Nancy T. Browne, Eric A. Hodges, Leigh Small, Julia A. Snethen, Marilyn Frenn, Sharon Y. Irving, Bonnie Gance-Cleveland, Cindy Smith Greenberg

College of Nursing Faculty Research and Publications

Despite decades of research and a multitude of prevention and treatment efforts, childhood obesity in the United States continues to affect nearly 1 in 5 (19.3%) children, with significantly higher rates among Black, Indigenous, and People of Colour communities. This narrative review presents social foundations of structural racism that exacerbate inequity and disparity in the context of childhood obesity. The National Institute of Minority Health and Health Disparities' Research Framework guides the explication of structurally racist mechanisms that influence health disparities and contribute to childhood obesity: biologic and genetic, health behaviours, chronic toxic stress, the built environment, race and cultural …

Functional Analysis Of A Novel De Novo Variant In Ppp5c Associated With Microcephaly, Seizures, And Developmental Delay, Sara M Fielder, Jill A Rosenfeld, Lindsay C Burrage, Lisa Emrick, Seema Lalani, Ruben Attali, Joshua N Bembenek, Hieu Hoang, Dustin Baldridge, Gary A Silverman, Undiagnosed Diseases Network, Tim Schedl, Stephen C Pak

2020-Current year OA Pubs

We describe a proband evaluated through the Undiagnosed Diseases Network (UDN) who presented with microcephaly, developmental delay, and refractory epilepsy with a de novo p.Ala47Thr missense variant in the protein phosphatase gene, PPP5C. This gene has not previously been associated with a Mendelian disease, and based on the population database, gnomAD, the gene has a low tolerance for loss-of-function variants (pLI = 1, o/e = 0.07). We functionally evaluated the PPP5C variant in C. elegans by knocking the variant into the orthologous gene, pph-5, at the corresponding residue, Ala48Thr. We employed assays in three different biological processes where pph-5 was …

Sars-Cov-2 Infection And Covid-19 Outcomes In Rheumatic Diseases: A Systematic Literature Review And Meta-Analysis, Richard Conway, Alfred H J Kim, Et Al.

2020-Current year OA Pubs

OBJECTIVE: The relative risk of SARS-CoV-2 infection and COVID-19 disease severity among people with rheumatic and musculoskeletal diseases (RMDs) compared to those without RMDs is unclear. This study was undertaken to quantify the risk of SARS-CoV-2 infection in those with RMDs and describe clinical outcomes of COVID-19 in these patients.

METHODS: We conducted a systematic literature review using 14 databases from January 1, 2019 to February 13, 2021. We included observational studies and experimental trials in RMD patients that described comparative rates of SARS-CoV-2 infection, hospitalization, oxygen supplementation/intensive care unit (ICU) admission/mechanical ventilation, or death attributed to COVID-19. Methodologic quality …

Experimental Cyclic Heat Stress On Intestinal Permeability, Bone Mineralization, Leukocyte Proportions And Meat Quality In Broiler Chickens, Alessandro Rocchi, Jared Ruff, Clay J. Maynard, Aaron J. Forga, Roberto Señas-Cuesta, Elizabeth S. Greene, Juan D. Latorre, Christine N. Vuong, Brittany D. Graham, Xochitl Hernandez-Velasco, Guillermo Tellez Jr., Victor Petrone-Garcia, Lauren Laverty, Billy Hargis, Gisela Erf, Casey M. Owens, Guillermo Tellez-Isaias

Poultry Science Faculty Publications and Presentations

The goal of this research was to assess cyclic heat stress on gut permeability, bone mineralization, and meat quality in chickens. Two separate trials were directed. 320 day-of-hatch Cobb 500 male chicks were randomly assigned to four thermoneutral (TN) and four cyclic heat stress (HS) chambers with two pens each, providing eight replicates per treatment in each trial (n = 20 chicks/replicate). Environmental conditions in the TN group were established to simulate commercial production settings. Heat stress chickens were exposed to cyclic HS at 35 °C for 12 h/day from days 7–42. Performance parameters, intestinal permeability, bone parameters, meat quality, …

Effect Of Cyclic Heat Stress On Hypothalamic Oxygen Homeostasis And Inflammatory State In The Jungle Fowl And Three Broiler-Based Research Lines, Giorgio Brugaletta, Elizabeth Greene, Alison Ramser, Craig W. Maynard, Travis Tabler, Federico Sirri, Nicholas B. Anthony, Sara K. Orlowski, Sami Dridi

Poultry Science Faculty Publications and Presentations

Heat stress (HS) is devastating to poultry production sustainability due its detrimental effects on performance, welfare, meat quality, and profitability. One of the most known negative effects of HS is feed intake depression, which is more pronounced in modern high-performing broilers compared to their ancestor unselected birds, yet the underlying molecular mechanisms are not fully defined. The present study aimed, therefore, to determine the hypothalamic expression of a newly involved pathway, hypoxia/oxygen homeostasis, in heat-stressed broiler-based research lines and jungle fowl. Three populations of broilers (slow growing ACRB developed in 1956, moderate growing 95RB from broilers available in 1995, and …

Histomonosis In Poultry: A Comprehensive Review, Lesleigh C. Beer, Victor M. Petrone-Garcia, B. Danielle Graham, Billy M. Hargis, Guillermo Tellez-Isaias, Christine N. Vuong

Poultry Science Faculty Publications and Presentations

Histomonas meleagridis, the etiological agent of histomonosis, is a poultry parasite primarily detrimental to turkeys. Characteristic lesions occur in the liver and ceca, with mortalities in turkey flocks often reaching 80–100%. Chickens and other gallinaceous birds can be susceptible but the disease was primarily considered sub-clinical until recent years. Treating and preventing H. meleagridis infection have become more difficult since 2015, when nitarsone was voluntarily removed from the market, leaving the poultry industry with no approved prophylactics, therapeutics, or vaccines to combat histomonosis. Phytogenic compounds evaluated for chemoprophylaxis of histomonosis have varied results with in vitro and in vivo …

Anxiety Symptoms Among Patients With Systemic Lupus Erythematosus Persist Over Time And Are Independent Of Sle Disease Activity, Daphne Lew, Xinliang Huang, Sara R Kellahan, Hong Xian, Seth Eisen, Alfred H J Kim

2020-Current year OA Pubs

OBJECTIVE: The objectives of this study are to identify patterns of anxiety symptomology over time among patients with systemic lupus erythematosus (SLE) and to assess the longitudinal relationship between SLE disease activity and anxiety symptomology.

METHODS: Longitudinal data from 139 patients with American College of Rheumatology or Systemic Lupus International Collborating Clinic (SLICC)-classified SLE were analyzed. Anxiety symptomology was assessed using the Patient-Reported Outcomes Measurement Information System (PROMIS) Emotional Distress: Anxiety Short Form 8a. SLE disease activity was measured using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)-2000 (S2K) and S2K Responder Index 50 (S2K RI-50). Group-based trajectory modeling (GBTM) …