Digital Commons Network^™

Racial And Ethnic Minority Supervisees’ Experiences In Clinical Supervision, Destiny Chanel Hill

Walden Dissertations and Doctoral Studies

Clinical supervision practices, although essential to counselor development, often reflect limited cultural competence among supervisors contributes to unclear expectations, conflicting roles, and isolation, leading to stress, negative internalization, and compromised professional development. The purpose of this hermeneutic phenomenological study was to explore the lived experiences of racial and ethnic minority supervisees in clinical supervision within the mental health counseling profession. The research question was: What are the lived experiences of racial and ethnic minority supervisees who have been involved in clinical supervision? The framework guiding the study was hermeneutic phenomenology. Data from interviews with eight participants were analyzed using the …

Wei Xiqin’S Evolutionary Plan For Modern China, Nianhong Qiu

Lingnan Theses (MPhil & PhD)

This study examines the thinking, practices, and significance of Wei Xiqin (1882- 1952). Born in Germany and educated in various European countries, Wei was a musician and educator who played an active role in the educational reform of the Republic of China. Wei was equipped with modern European thoughts but held deep reverence for Confucianism and other traditional Chinese classics. Examining this contentious figure in the wake of “Chinese Evolutionism” trend, this study investigates the differences between Wei’s evolution theory and the dominant evolution theory during early 20th-century China. Wei’s evolutionism, which I call a type of “Cyclic Evolution,” implies …

Full Issue, Iajbs Ateneo De Manila University

Journal of Management for Global Sustainability

No abstract provided.

A Prognostic Matrix Gene Expression Signature Defines Functional Glioblastoma Phenotypes And Niches, Monika Vishnoi, Zeynep Dereli, Zheng Yin, Elisabeth K Kong, Meric Kinali, Kisan Thapa, Ozgun Babur, Kyuson Yun, Nourhan Abdelfattah, Xubin Li, Behnaz Bozorgui, Mary C Farach-Carson, Robert C Rostomily, Anil Korkut

Faculty, Staff and Student Publications

Interactions among tumor, immune, and vascular niches play major roles in glioblastoma (GBM) malignancy and treatment responses. The composition and heterogeneity of extracellular core matrix proteins (CMPs) that mediate such interactions are not well understood. Here, we present an analysis of the clinical relevance of CMP expression in GBM at bulk, single-cell, and spatial anatomical resolution. We show that CMP enrichment is associated with worse patient survival, specific driver oncogenic alterations, mesenchymal state, pro-tumor immune infiltration, and immune checkpoint expression. Matrisome expression is enriched in vascular and leading edge/infiltrative niches that are known to harbor glioma stem cells. Finally, we …

Precision Targeting Of Sting: Challenges, Innovations, And Clinical Outlook For Cancer Therapy, Jiaqi Shi, Yingying Zhang, Na Zhao, Ekihiro Seki, Li Ma, Gordana Kocic, Xiaobo Li, Janoš Terzić, Tongsen Zheng

Faculty, Staff and Student Publications

The stimulator of interferon genes (STING) pathway plays a crucial role in immune responses and has emerged as a compelling target in cancer therapy. Despite promising preclinical studies, clinical trials of STING agonists have largely failed to deliver durable efficacy, with no agents progressing to phase III trials. This review examines the biological, pharmacological, and clinical barriers limiting STING pathway activation in cancer treatment. We discuss the inherent limitations of STING agonists as well as host-related resistance driven by tumor heterogeneity, immune suppression, and chronic STING activation. Mechanisms of acquired resistance, such as immune checkpoint upregulation and suppression of effector …

System And Method For Autonomous Cross-Domain Collaborative Artificial Intelligence–Driven Discovery And Innovation, Chiranthan N

Defensive Publications Series

The presented proposal discloses a system and method for autonomous, collaborative artificial intelligence–driven discovery and innovation. The techniques presented herein enables structured interaction among multiple specialized AI software agents, each possessing domain-specific expertise, to perform real-time cross-domain reasoning without continuous human intervention. An interaction controller governs communication, reasoning exchange, and collaboration rules among the agents, while an evaluation module assesses novelty, feasibility, and domain validity of generated outputs. Through iterative feedback and refinement, the proposed system synthesizes knowledge across disciplines to generate robust, non-obvious solutions and inventive outcomes. The proposed architecture overcomes limitations of conventional single-domain and task-parallel AI systems …

Stakeholder Perspectives On Humanistic Implementation Of Computer Perception In Health Care: Qualitative Study, Kristin M Kostick-Quenet, Meghan E Hurley, Syed Ayaz, John D Herrington, Casey J Zampella, Julia Parish-Morris, Birkan Tunç, Gabriel Lázaro-Muñoz, Jennifer Blumenthal-Barby, Eric A Storch

Center for Medical Ethics and Health Policy Staff Publications

Background: Computer perception (CP) technologies-including digital phenotyping, affective computing, and related passive sensing approaches-offer unprecedented opportunities to personalize health care, especially mental health care, yet they also provoke concerns about privacy, bias, and the erosion of empathic, relationship-centered practice. At present, it remains elusive what stakeholders who design, deploy, and experience these tools in real-world settings perceive as the risks and benefits of CP technologies.

Objective: This study aims to explore key stakeholder perspectives on the potential benefits, risks, and concerns associated with integrating CP technologies into patient care. A better understanding of these concerns is crucial for responding to …

Xenobot-Inspired Diatom Analogues For Synthetic Kinematic Renewal Of Regenerative Nanobot Payloads, Suma Mallapragada, Vaishnavi Sankepally, Anishkumar Manoharan, Muhamed Fazl, Cherukuri Dhawal, Shreya Abhijit Patki, Kethavarapu Uma Eswar Datta Sai

Defensive Publications Series

A system and method are presented for a time-bounded, non-genetic regeneration framework in which synthetic, diatom-shaped functional organelles are continuously produced, deployed, and exhausted within a confined system. The approach relies on geometry-driven kinematic assembly, droplet and gel physics, and swarm-level population homeostasis rather than cellular replication or organism growth. A critical design invariant enforces the release of exactly two functional organelles per release event, ensuring bounded output, predictable dynamics, and safety. The disclosure provides laboratory-recognizable implementation pathways suitable for materials science, soft-matter physics, and bioengineering groups and is released for public use to establish prior art.

Β2 And Β3a Regulatory Subunits Can Coassemble In The Same Bk Channels, Yu Zhou, Vivian Gonzalez-Perez, Xiao-Ming Xia, Gopal S Kallure, Sandipan Chowdhury, Christopher J Lingle

2020-Current year OA Pubs

Ca2+- and voltage-activated BK-type K+ channels are influenced profoundly by associated regulatory subunits, including β subunits (Kcnmb1-4; β1-β4). Although overlap in expression of different BK β subunits occurs in native tissues, whether they can coassemble in the same channel complex is not known. We coexpress β2 and β3a subunits together with BK α and, through a combination of macroscopic and single-channel recordings, along with quantitative pull-down of tagged subunits, test whether coassembly can occur. We evaluate two models: (1) random mixing in which β2 and β3a subunits coassemble in the same channels, and (2) segregation in which β2 and β3a …

Accurate Chromatin Marks Peak Calling With Omnipeak, Oleg Shpynov, Maxim N Artyomov

2020-Current year OA Pubs

Chromatin immunoprecipitation sequencing (ChIP-seq) is a widely used technique for identifying transcription-factor binding and histone modifications across the genome. Peaks in ChIP-seq data vary in length depending on the biological context, from narrow transcription factor binding sites to broad histone modification domains. However, commonly used peak-calling tools are tailored to the specific types of data and struggle to consistently handle various peak lengths, datasets of varying quality, and missing control tracks-common issues in comparative or meta-analyses. These limitations are addressed with Omnipeak, a universal unsupervised peak-calling algorithm based on a constrained three-state hidden Markov model. Omnipeak accurately models global genomic …

Towards A Unified Gating Scheme For The Cnbd Ion Channel Family, Jenna L Lin, Baron Chanda

2020-Current year OA Pubs

Cyclic nucleotide-binding domain (CNBD) channels are critical components of numerous bioelectrical processes, including cardiac pacemaking, neuronal signaling, phototransduction in the eye, and stomatal regulation in plants. While members of this channel family share a conserved overall structure, they exhibit striking differences in voltage sensitivity. Hyperpolarization-activated cyclic nucleotide-gated channels are activated by membrane hyperpolarization, whereas ether-à-go-go channels open upon depolarization. Mutagenesis and chimeragenesis studies have revealed that some mutants display bipolar gating behavior-remaining closed at intermediate membrane potentials but capable of opening in response to both hyperpolarization and depolarization. Remarkably, in certain cases, just a few mutations are sufficient to reverse …

System And Method For Autonomous Cross-Domain Collaborative Artificial Intelligence–Driven Discovery And Innovation, Chiranthan N

Defensive Publications Series

The presented proposal discloses a system and method for autonomous, collaborative artificial intelligence–driven discovery and innovation. The techniques presented herein enables structured interaction among multiple specialized AI software agents, each possessing domain-specific expertise, to perform real-time cross-domain reasoning without continuous human intervention. An interaction controller governs communication, reasoning exchange, and collaboration rules among the agents, while an evaluation module assesses novelty, feasibility, and domain validity of generated outputs. Through iterative feedback and refinement, the proposed system synthesizes knowledge across disciplines to generate robust, non-obvious solutions and inventive outcomes. The proposed architecture overcomes limitations of conventional single-domain and task-parallel AI systems …

Micrornas In Prostate Cancer Liquid Biopsies: Early Detection, Prognosis, And Treatment Monitoring, Seyyed Mohammad Yaghoubi, Erfan Zare, Sina Jafari Dargahlou, Maryam Jafari, Mahdiye Azimi, Maedeh Khoshnazar, Solmaz Shirjang, Behzad Mansoori

Student Papers, Posters & Projects

Prostate cancer (PCa) is a common malignancy in men worldwide, with incidence projected to rise in the coming years. Traditional screening and diagnostic methods, such as prostate-specific antigen (PSA) testing and biopsy, face limitations in specificity and invasiveness. Circulating microRNAs (miRNAs) have emerged as stable, non-invasive biomarkers obtainable via liquid biopsies (blood, urine, semen) that could transform PCa management. These small regulatory RNAs reflect underlying tumor biology and are detectable at early disease stages, enabling improved early detection when used alongside or in place of PSA. Distinct miRNA expression patterns correlate with tumor aggressiveness. For example, miR-141 and miR-375 are …

Exploring In Vitro Interactions Of Core Microbes From The Ciona Robusta Gut, Yanori M. Ferguson, Alyssa L. Fischer, Ojas Natarajan, Larry J. Dishaw

Making Waves REU

The disruption of homeostasis in the gut microbiome is linked to various host immune and metabolic imbalances. Therefore, there is a need to elucidate the roles of microbes in maintaining homeostasis in the gut microbiome.

Fungi are often overlooked components of gut flora. Here, we investigate in vitro interactions between core microbiota genera from the C. robusta gut: Candida (a yeast), Pseudoalteromonas (bacteria) and Vibrio (bacteria).

Table Of Contents, Georgia State University College Of Law

Georgia State University Law Review

No abstract provided.

Perspectives From The 2025 Iscbi/Isci Joint Workshop On Genetic Stability, Clonal Monitoring, Ethical Data Governance, And Global Inclusion In Stem Cell Banking., Jung-Hyun Kim, Andreas Kurtz, Ivana Barbaric, Maneesha S Inamdar, Martin Pera, Nissim Benvenisty, Nika Shakiba, Rosario Isasi, Tadaaki Hanatani, Glyn Stacey

Faculty Research 2026

Two international stem cell consortia, the International Stem Cell Initiative (ISCI) and the International Stem Cell Biobanking Initiative (ISCBI, www.iscbi.org ) held a workshop on June 15th 2025 in Hong Kong on genetic variants in human pluripotent stem cell (hPSC) lines and accurate and standardized documentation of donor/hPSC genetic information including ethnicity. The occurrence and detection of genetic variants is a key issue for assuring reproducible stem cell research data and the safety of stem cell derived medicinal products. Presentations by leading experts addressed the nature of hPSC genetic variants, their detection and accurate recording of genetic data and ethnicity. …

The Human Person As Relatio In Joseph Ratzinger’S Logos-Dialogos Theology, Junmar Cris N. Caputolan

Loyola Papers

This article examines the concept of the human person as relatio in the theology of Joseph Ratzinger. Marking the twentieth anniversary of Ratzinger’s election as pope, the paper situates his Logos-Dialogos theology at the intersection of Christology and theological anthropology. It traces the development of personhood from Augustine of Hippo and Boethius to Richard of St. Victor, culminating in Ratzinger’s relational vision of the human person. The study highlights how faith, reason, and love converge in a dialogical understanding of personhood oriented toward communion with God and others.

Henze, Rosemary C., San Jose State University

Emeritus and Retired Faculty Biographies

Stanford University, Education (Language, Literacy & Culture), Ph.D. 1988

San Francisco State University, English (TESL), M.A. 1980

University of California, Santa Cruz, Art, B.A. 1974

The Experience Of Women’S Dignity In The Angolan Synodal Church: A Pastoral Critical Re-Reading Of Mulieris Dignitatem From Angolan Cosmology, José Abílio Praia

Loyola Papers

This article critically reexamines Mulieris Dignitatem within the context of Angolan cultural cosmology. The study highlights the tension between the symbolic reverence for women and their social marginalization in Angola. Employing feminist and pastoral perspectives, it explores how indigenous relational and life-giving concepts of womanhood can enrich theological reflection. By engaging African and Asian feminist insights, the paper proposes a synodal ecclesiology grounded in lived experience, co-responsibility, and structural transformation, emphasizing women’s dignity as integral to the Church’s identity and mission.

Sediment Grain Size Distribution And Composition From Coastal Enviroments At Jobos Bay National Estuarine Research Reserve, Puerto Rico, Xiomara Cruz-De León, Angelique Rosa Marín, Natalia B. López-Figueroa, Pamela Hallock

Making Waves REU

• Grain size analysis is an essential technique in sedimentology, providing vital information on sedimentary processes and depositional environments in coastal and marine systems.
• This study focuses on the Jobos Bay National Estuarine Reserve (JBNERR) in Guayama, Puerto Rico, an estuary significantly influenced by both natural and anthropogenic factors.
• The objective of this research is to compare the composition and textures of sediments collected from 16 sites across various habitats at Jobos Bay in December 2023.
• This study aims to support ongoing research initiatives and contribute to the effective management of the estuary.

Bromodomain And Extra-Terminal Protein Inhibitors Modulate Natural Killer Cell Function And Differentiation., Eric S. Geanes, Gage Greening, Maria Aggelakopoulou, Linh Huyen Truong, Santosh Khanal, Cas Lemaster, Marc L. Herman, Rebecca Mclennan, Persephone Borrow, Todd Bradley

Manuscripts, Articles, Book Chapters and Other Papers

Natural killer (NK) cells are integral to the innate immune system, playing a crucial role in immune surveillance and the rapid response to virally infected and tumor cells. Epigenetic gene expression regulation significantly influences NK cell function and differentiation. Using a high-throughput small-molecule drug screening approach, we identified bromodomain and extra-terminal domain (BET) inhibitors (BETi) as potent modulators of NK cell function, reducing proinflammatory cytokine secretion while increasing markers of NK cell maturation and cytotoxicity. During NK lineage specification from hematopoietic stem cells, we demonstrated that BETi reduced NK cell fate and promoted increased myeloid cell differentiation. Moreover, differentiated NK …

Clinical And Radiological Outcomes Of Directed Treatment Transitions From Gilenya® To Generic Fingolimod, Mahi A. Patel, Tom G. Punnen, Kevin S. Shan, Morgan C. Mccreary, Crystal M. Wright, Shanan B. Munoz, Paula Hardeman, Katy W. Burgess, Benjamin M. Greenberg, Lindsay A. Horton, Peter V. Sguigna, Lauren M. Tardo, Olaf Stüve, Darin T. Okuda

Student Publications

Background: Gilenya® (fingolimod), a sphingosine-1-receptor agonist, is an effective treatment for multiple sclerosis (MS). However, increased relapse activity has been observed after transitioning to generic fingolimod despite prior prolonged disease stability.

Objective: To quantify the clinical and radiological impact of transitioning from Gilenya® to generic fingolimod in people with MS (PwMS).

Methods: Retrospective data were evaluated from a single tertiary MS care center. Time to magnetic resonance imaging (MRI) activity and clinical relapse was assessed during Gilenya® and generic fingolimod treatment. Differences in absolute lymphocyte count (ALC) and side effects were also measured by treatment group.

Results: The cohort included …

Anti-Csf-1r Therapy With Combined Immuno-Chemotherapy Coordinate An Adaptive Immune Response To Eliminate Macrophage Enriched Triple Negative Breast Cancers, Diego A Pedroza, Xueying Yuan, Fengshuo Liu, Hilda L Chan, Christina Zhang, William Bowie, Alex J Smith, Sebastian J Calderon, Nadia Lieu, Weiguo Wu, Paul Porter, Poonam Sarkar, Na Zhao, Constanze V Oehler, Ondrej Peller, M Waleed Gaber, Qian Zhu, Charles M Perou, Xiang H-F Zhang, Jeffrey M Rosen

Faculty, Staff and Students Publications

Women diagnosed with metastatic triple negative breast cancer (mTNBC) have limited treatment options, are more prone to develop resistance and are associated with high mortality. A cold tumor immune microenvironment (TIME) characterized by low T cells and high tumor associated macrophages (TAMs) in mTNBC is associated with the failure of standard-of-care chemotherapy and immune checkpoint blockade (ICB) treatment. We demonstrate that the combination of immunomodulatory low-dose Cyclophosphamide (CTX) coupled with anti-CSF-1R antibody targeted therapy (SNDX-ms6352) and anti-PD-1 (ICB), was highly effective against aggressive metastatic Trp53 null TNBC transplantable syngeneic models that present with high macrophage infiltration. Mechanistically, CSF-1R inhibition along …

Celltra: Aligning Cell Names With Gene Expression Via A Pathway-Informed Transformer, Zhao Li, Zaiyi Zheng, Rongbin Li, Wenbo Chen, Yuntao Yang, Meer A Ali, Jundong Li, W Jim Zheng

Faculty, Staff and Student Publications

Motivation: Single-cell RNA sequencing (scRNA-Seq) technology enables detailed exploration of gene expression at the individual cell level, crucial for annotating cell types and understanding cellular diversity. Traditional methods for cell type annotation often rely on marker genes and manual labeling, posing challenges due to low data quality and incomplete reference datasets.

Results: We developed CeLLTra, a novel contrastive learning framework that leverages a Transformer-based model integrating biological pathway information to group genes into super tokens, effectively capturing comprehensive gene expression from scRNA-Seq data. By combining this pathway-informed Transformer with a pretrained domain-specific language model, CeLLTra accurately aligns cell-type annotations with …

Buddha’S Dhammapada And Jesus Christ’S Parable Of The Rich Man And Lazarus: Evil, Freedom, And Divine Justice, Kevin Stephon R. Centeno

Loyola Papers

This article presents a comparative study of moral evil, human freedom, and justice in the Dhammapada and the Parable of the Rich Man and Lazarus. Engaging insights from Paul Ricoeur and John Hick, the study examines how Buddhism and Christianity interpret the moral consequences of human actions. While differing in theological foundations—karmic law and divine justice—the traditions converge in affirming moral responsibility and the inevitability of ethical consequences, offering valuable insights for interreligious dialogue and contemporary ethical reflection.

A Probabilistic Modeling Analysis Of The Longitudinal Immune Response To Infection And Vaccination Across Demographic Groups And Pulmonary Symptoms, James O'Hanlon, Kaitlyn Sullivan, Lyndsey M. Muehling, Glenda Canderan, Jie Sun, Judith A. Woodfolk, Jeffrey M. Wilson, Rayanne A. Luke

Spora: A Journal of Biomathematics

Antibody and cytokine kinetics describe the dynamic response to immune events such as infection and vaccination. These dynamics are not fully understood, and mathematical characterization may help explain variability across demographic groups and pulmonary symptoms post-acute infection. We fit time-dependent probability models to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) data to obtain distributions of longitudinal antibody response and cytokine values. To assess differences between groups, an overlap metric is applied to the modeled response curves. Our antibody models suggest significant differences between male and female populations and demonstrate deficient antibody responses of less-healthy groups such as smokers. Our cytokine …

Can Physical Activity Improve Students' Stem Achievement? Results Of The Lithuanian Study Of Students In Grades 5–8, Agne Brandisauskiene, Julius Venskus, Egle Kemeryte-Ivanauskiene

Baltic Journal of Health and Physical Activity

Abstract: Background: Recognising the importance of physical activity for students' overall well-being and cognitive functioning, this study aims to investigate the relationship between the achievement of students in grades 5–8 in STEM subjects and their non-formal physical activity. Materials and Methods: The data for this study were gathered from the Lithuanian school management system. To categorize the marks into STEM subjects and non-formal physical sport activities, a RoBeRTa pre-trained model, a tool based on Natural Language Processing (NLP), was utilized. For the hypothesis testing of non-normally distributed data, the Mann–Whitney U test was employed. Results: The results of study show …

Predicting The Peak Bloom Of Yoshino Cherry Blossoms In Washington, Dc With Random Forest Regression, James Watkins, Ian Forde, Rene Salinas

Spora: A Journal of Biomathematics

Springtime ushers in a bouquet of flowering arrangements that create ripe economic and social opportunities. Since the Japanese ambassador's gift of 3020 Yoshino cherry trees to the National Mall in Washington, DC, the National Cherry Blossom Festival has occurred annually beginning in 1935. This festival is unique in that over one million visitors parade the Capitol area each year, drawing inspiration from the peak blooming date of the characteristic cherry trees. The NPS provided data on the several stages of Yoshino cherry trees leading to peak bloom from 2004–2024, while local climate data exists for temperature, rainfall, and other factors …

Decoding Early Covid-19 Responses Using Mathematical Modeling Of Social Distancing Strategies Across Multiple Countries, Sri Gunturu, Suki Lewis, Katelyn Nguyen, Asma Azizi

Spora: A Journal of Biomathematics

During the early phase of the COVID-19 pandemic, before vaccines were available, countries implemented diverse combinations of social-distancing (SD) measures shaped by cultural norms and public acceptance. These differences produced varied outcomes in controlling viral spread, offering lessons for future health-crisis preparedness. We performed a reverse-engineering analysis of early COVID-19 case data from five socioculturally distinct countries—India, Vietnam, Italy, Finland, and the United States—selected to capture a range of initial prevalence levels. Using mathematical modeling and data fitting, we inferred the relative contributions of three SD interventions: face masking, quarantine, and isolation of infected individuals. We then employed an efficiency …

Optimal Intervention Strategies In Age-Structured Sirvd Model: Epidemiological And Economic Analysis Of Covid-19 In Korea, Joon Chun, Melisa Hendrata

Spora: A Journal of Biomathematics

This study employed an age-structured Susceptible-Infected-Recovered-Vaccinated-Deceased (SIRVD) model to design optimal COVID‑19 intervention strategies by integrating epidemiological dynamics with economic costs. Using empirical data from South Korea, we estimated transmission parameters and analyzed quarantine-based non-pharmaceutical interventions (NPIs) alongside targeted vaccination scenarios. Our results indicated that a stronger form of mild NPI (upper range of Level I), when combined with targeted vaccination that prioritized seniors, achieved substantial reductions in infection peaks and overall economic burden. These findings underscore the effectiveness of age-specific strategies in epidemic management and offer critical insights for policymakers seeking balanced, resource-efficient approaches.