Digital Commons Network^™

The Mono Basin Project: Remedying Environmental Injustice Through Tribal Beneficial Use Designations, Molly Greene

UC Law Environmental Journal

Due to a history of violence, dispossession, and racism, Native American tribes in California face structural disadvantages and inequities with respect to water rights. At the same time, tribes lack meaningful legal remedies to gain access to the water resources necessary to maintain their ways of life. One key issue is that California water agencies traditionally did not consider tribal water uses when implementing water quality control laws, leaving such uses unprotected. For years, tribes have urged the State to fill in these gaps in the law by adopting tribal beneficial uses (“TBUs”), which would protect tribal water uses, such …

The Effects Of Bone-Remodeling Therapy On Survival, Pain, And Skeletal Related Events In The Setting Of Renal Cell Carcinoma With Bone Metastases: A Multicenter Investigation From A Large Global Health Research Network (Trinetx), Brian H. Im, Kevin K. Zarrabi, Aaron R. Hochberg, Mihir M. Shah, Md, James R. Mark, Joseph K. Izes, Patrick T. Gomella, Costas D. Lallas, Leonard G. Gomella, Adam R. Metwalli

Department of Urology Faculty Papers

INTRODUCTION: Renal cell carcinoma (RCC) is the most common renal malignancy-bone metastases (BM) are indicative of aggressive disease with a poor prognosis. We aim to evaluate the overall mortality of patients with RCC with and without BM, and to elucidate the effects of bone-remodeling therapy on mortality, incidence of skeletal-related events, and opioid usage patterns in patients with BM.

METHODS: A retrospective cohort study was conducted using TriNetX, a large, collaborative network sourced from electronic medical records of over 110 million patients from over 100 healthcare organizations. All adult patients with RCC and RCC with BM were queried.

RESULTS: There …

The Case For A Moratorium On Deep-Sea Mining: The International Seabed Authority, Indigenous Rights, And Marine Ecosystems In The Eastern Pacific, Afrah A. Qoqandi

UC Law Environmental Journal

The rising interest in deep-sea commercial exploitation has sparked a powerful debate over the environmental and social justice implications of mining the ocean’s depths for valuable minerals. Deep-sea mining targets polymetallic nodules found on the seabed, containing metals critical for green technologies like electric vehicles and solar cells. The Clarion-Clipperton Zone (“CCZ”) in the eastern Pacific is estimated to hold more nickel, manganese, and cobalt than all terrestrial resources combined. As one of the last largely untouched ecosystems, deep-sea mining in the CCZ raises significant concerns about the irreversible harm to its biodiversity and the disruption to Indigenous communities reliant …

Investigating The Reliability And Validity Of The Social Connectedness Instrument Among U.S. Adults, Blake A. Fraser

Doctoral Dissertations and Projects

Growing evidence shows that poor social connectedness is becoming a public health threat, with rising prevalence and connections to poor mental and physical health across the lifespan. Therefore, there is an urgent need to develop feasible and effective social connectedness interventions. There is limited evidence for the effectiveness of current interventions, with studies recommending tailoring the intervention to an individual’s specific social connection needs. However, previous measures of social connectedness provide little information about potentially modifiable contributors of poor connection. Thus, the Social Connectedness Instrument (SCI) was developed to fill in this gap by proposing two novel latent constructs of …

2026-01-14 ‘Redhawk Games’ Kick Off The Quarter With Laser Tag And Axe Throwing, Tobias Scott

The Spectator Online

No abstract provided.

Brain Tumor Segmentation Based On Convolutional Neural Network And Integration Of Deep And Shallow Features, Rula Sami Aleesa

Baghdad Science Journal

Segmentation of Brain tumors refers to one of the most challenging problems in analyzing a medical image. To establish accurate brain tumor region delineation, brain tumor segmentation is used. Feature extraction refers to one of the basic steps in the processing of an image that aids classification. Various features’ kinds are extracted from MRI images. The traditional classifiers of Machine learning need hand-crafted features that are time-consuming and susceptible to errors made by humans. Against this, Deep learning is too powerful in terms of feature extraction and has already been extensively applied for the aims of classification. The presented technique …

Bioinformatics-Inspired Secure Video Encryption Using Chaotic Maps And Light Streaming Algorithms, Rajaa K. Hasoun, Rasha S. Ali, Ahmed G. Hameed, Ghassan H. Abdul-Majeed

Baghdad Science Journal

The Traditional encryption methods, such as AES, can be too slow for large video files, necessitating the development of faster and more efficient solutions for real-time video security. This research aims to enhance video security during transmission by developing a novel video encryption algorithm that is both fast and robust, specifically designed to handle large video datasets efficiently. The proposed video encryption algorithm integrates lightweight streaming algorithms for enhanced speed, modern cryptographic techniques, and chaotic maps for heightened security. The encryption process involves three key steps: Dividing the video into frames and scrambling/encrypting each frame, employing three innovative techniques: vertical …

Developing Pattern Recognition And Interpretable Convolutional Neural Network Based Frameworks For Identifying Drug Resistant And Pan Cancer Mirnas From Expression Data, Joginder Jsingh

Doctoral Theses

Micro Ribonucleic Acids (miRNAs) are short length (∼24) non-coding RNAs and are considered as key biomarkers in cancer diagnosis and treatment. They play a vital role in classifying cancer patients from normal ones and drug resistant patients from control ones. The control patients are those who have not received any drug for cancer treatment. The objective is to identify a subset of miRNAs those help in the classification of the patients using expression data. The thesis is comprised of four contributory chapters in addition to an introduction and conclusion. In the first two contributory chapters, computational methods for ranking and …

Expansion Of Federal Benefits To Non-Native Adopted Children, Anna-Grace Hockensmith

American Indian Law Journal

There is palpable tension between tribal sovereignty and federal administrative control in the distribution of federal benefits to members of Tribal Nations. This tension is felt by adopted non-Native children who might struggle to receive federal benefits even though the tribe of their adopted parent(s) has accepted them as a member. This Note explores how adoption of a non-Native child by a tribal member intersects with tribal membership and whether that membership should be enough for the child to receive federal benefits.

The Note discusses four main topics, including: (1) tribal membership, adoption, and current federal enrollment criteria; (2) an …

2026-01-14 What Comes Next? Seattle U Seniors Share Their Stories, Maya Deguzman

The Spectator Online

No abstract provided.

Muc13 Is A Crucial Player In Yap1-Β-Catenin Survival Complex Mediated Cancer Metastasis, Shabnam Malik, Mohammed Sikander, Murali Yallapu, Subhash Chauhan

School of Medicine Publications

No abstract provided.

5539-181 & 182 Prospect Park W. Brooklyn Llc V. Rivera

All Decisions

In this licensee holdover for succession rights to a rent-controlled apartment, the landlord sought possession after the tenant-of-record's death, alleging the respondent was a licensee without succession. The landlord served judicial subpoenas on the Administration for Children's Services (ACS) and the Office of Children and Family Services (OCFS) for extensive records related to the deceased tenant's foster parenting. The tenant moved to quash the ACS subpoena, arguing it was impermissibly broad, a fishing expedition, and sought confidential information about non-party minors. The court granted the tenant's motion, finding the landlord was not a proper party to seek foster care records …

A187: The Comprehensive Impact Of Competitive Liondance On Bio-Psycho-Social Health: Cohort Tracking Study Of Elite Athletes, Yong Zhu

International Journal of Physical Activity and Health

Competitive lion dance, a traditional sport that integrates artistic performance, cultural heritage, and high-intensity physical training, has not yet been systematically studied for its multidimensional health benefits. Method: This study investigates the comprehensive impact of competitive lion dance on the bio-psycho-social health of elite athletes through a 12-month longitudinal cohort tracking. Thirty-two national-level competitive lion dance athletes (18 males and 14 females, aged 22.5 ± 3.1 years) were recruited and assessed at three time points: baseline, 6 months, and 12 months. Biological health indicators included cardiorespiratory fitness (maximal oxygen uptake, VO₂max), muscle strength (isokinetic strength test), and body composition analysis. …

A223: Does The Induced Pap Effect Have An Impact On The Squatting Start Of Swimming, Jiayi Lyu, Jie Gao, Xinyi Li

International Journal of Physical Activity and Health

Post activation potential (PAP) is one of the hot topics in warm-up preparation and physical training. This article explores the effect of inducing PAP on swimming start by using an 85% RM barbell squat in the lower limbs and investigates the impact of PAP 9 minutes after the squat start. Method: This article adopts an experimental method. The study selected 8 university swimming specialized student athletes and used the testing equipment Kistler to shoot videos and obtain data on their exercise biological force and time. The paired sample t-test was used to process the pre-test and post-test related data. After …

A263: Exploring Cadd-Based Binding Modes Of Androstenedione And Its Metabolites With Potential In Vivo Targets, Yuhong Ding, Wei Dong

International Journal of Physical Activity and Health

The abuse of androstenedione, an endogenous steroid hormone, among athletes to enhance performance is a significant concern in sports. Current anti-doping detection methods are limited by short detection windows and high false-positive rates, largely due to the transient nature of primary metabolites. To address these challenges, this study employs computer-aided drug design (CADD) to identify stable, long-acting metabolites of androstenedione that can extend the detection window and improve anti-doping efficacy. The integration of CADD with sports physiology principles allows for a more comprehensive understanding of how exercise-induced metabolic fluctuations can influence the detection of these metabolites. Method: Molecular docking simulations …

A094: Dose-Response Effects Of Tennis Participation On Cardiorespiratory Fitness In College Students, Xianyue Li

International Journal of Physical Activity and Health

Based on the FITT-VP principle, this study investigated the dose-response relationship between tennis participation and cardiorespiratory fitness (CRF) in college students. Addressing the current reliance on expert consensus for exercise prescription and the lack of dose-regulation mechanisms, this study focused on high-intensity interval training (HIIT) and sprint interval training (SIT). It aimed to analyze the dynamic relationship and biological mechanisms between exercise intensity (SIT: 80-100% HRmax vs. HIIT: 75-90% HRmax), duration (8 weeks, frequency 2-3 sessions/week), and key CRF indicators (VO2max, anaerobic threshold, and exercise efficiency). Forty healthy college students with similar tennis experience were randomly assigned to HIIT (n=10), …

A097: Intelligent Exercise Prescription Facilitates The Development Path Of Sports For Obese Populations, Qiqi Huang

International Journal of Physical Activity and Health

The global population of individuals is expanding rapidly. By 2024, the obesity rate among adults in China is expected to surge to 16.4%, while globally, over 4 billion people are facing issues of overweight or obesity. Traditional exercise prescriptions suffer from the limitations of "generalized guidance" and "static prescriptions." Studies have shown that due to the neglect of individual metabolic differences, only 20% of individuals can maintain clinically significant weight loss for more than 12 months, and merely 10-25% patients can sustain a weight loss of ≥10% in the long term. The intelligent technology-driven exercise intervention system is reshaping the …

A146: Independent And Joint Role Of Inflammatory Diet And Physical Activity In The Acceleration Of Aging, Shuting Peng, Yu Jiang

International Journal of Physical Activity and Health

Biological aging arises from the accumulation of molecular changes or “hallmarks”, which can represent a person's aging status than chronological age. A healthy lifestyle can slow biological aging and prevent or delay the onset of multiple age-related diseases. This study is the first to investigate the independent and joint association of physical activity (PA) and inflammatory diet with acceleration of aging. Method: Data from 4767 participants in the 2017-2020 National Health and Nutrition Examination Survey (NHANES) were analyzed. Binary logistic regression models, adjusted for age, sex, race, socioeconomic status, smoking, and sleep disturbances, were used to assess the independent and …

A227: Eliminate Or Evolve: Digital Transformation Of Paris 2024 Olympics Under Olympic Ai Agenda, Tong Zheng

International Journal of Physical Activity and Health

The International Olympic Committee (IOC) has been promoting sports digitalization since the early 2000s, with the Olympic Agenda 2020 and the Olympic AI Agenda in 2024 providing strategic frameworks for this transformation. This paper examines how digital and AI technologies were applied at the 2024 Paris Olympics, the first Games guided by the exploration of impact on the Olympic movement and global sports landscape. Method: Using literature reviews and case studies from academic platforms like CNKI, WanFang, and Web of Science, this study analyzes digital transformation examples at the Paris 2024 Olympic Games. AI empowering the Olympics under the "Agenda" …

Exploring The Counselor Identities Of Latina Counselors Through The Lens Of Their Familial, Cultural, And Religious Contexts: A Phenomenological Study, Samuel Landa

Doctoral Dissertations and Projects

Developing a counselor identity is an essential component of becoming a counselor. There are several factors influencing the developmental process. Though there are several studies that explore the topic of counselor identity development, the research on what this process entails for Latina counselors is limited. Thus, this transcendental phenomenological qualitative study explores how family, culture, and religion influence the counselor identity development of Latina counselors. This study utilized Schlossberg’s transition theory (1981) to observe how these factors become evident in the first year of their Council for Accreditation of Counseling and Related Educational Program (CACREP) and how they influenced their …

Ophiobolin A Impacts Mitochondrial Redox Biology In An Epithelial-Mesenchymal Transition (Emt)-Specific Manner, Haleigh N Parker, Yongfeng Tao, Jenna Tobin, Kayla L Haberman, Samantha Davis, Emily York, Alysia Martinez, Nobuyuki Matsumoto, Jaquelin Aroujo, Jun Hyoung Park, Bernd Zechmann, Benny Abraham Kaipparettu, Angela Boari, Christie M Sayes, Antonio Evidente, Alexander Kornienko, Benjamin Cravatt, Daniel Romo, Joseph H Taube

Faculty, Staff and Students Publications

Breast cancer progression is facilitated by the epithelial to mesenchymal transition (EMT), generating cancer cells with enhanced metastatic capacity and resistance to chemotherapeutics. The fungus-derived sesterterpenoid natural produce compound, ophiobolin A (OpA), possesses nanomolar cytotoxic activity and a high therapeutic index, although its molecular targets and mechanism of action are not well characterized. Herein, we utilized a model of mammary epithelial cells and breast cancer cell lines with and without EMT features to characterize the mechanism of selectivity towards EMT(+) cells by OpA. Proteins interacting with OpA in EMT(+) cells, including mitochondrial glutathione transporter SLC25A40, were identified through via mass …

Progress And Challenges In Profiling Protein-Rna And Protein-Associated Rna-Rna Interactions, Zhuoyi Song, Eric L Van Nostrand

Faculty, Staff and Students Publications

RNA binding proteins (RBPs) play essential roles in post-transcriptional gene regulation by interacting with a wide range of RNA targets. In addition to regulating RNA processing via individual RBP-RNA interactions, there is a growing appreciation of the regulatory impact of protein-associated RNA-RNA interactions that include both well-studied examples of small regulatory RNAs (e.g. microRNAs, snRNAs, snoRNAs, piRNAs) guiding ribonucleoprotein complexes to their targets as well as structured RNA elements defining the interaction landscape for an RBP. To elucidate the full scope of RBP-RNA interactions, CLIP ( crosslinking and immunoprecipitation)-based methods have emerged as powerful tools. Even with the wide application …

Variances In Power Output Of Female Athletes During The Menstrual Phases, Julia L. Allen

Masters Theses

The purpose of this research was to examine if there are any variances in a female athlete’s ability to produce power, that could be correlated with the menstrual cycle phases. The study observed three elite female athletes throughout 13 weeks, collecting relative propulsive power and relative braking power data from their vertical jump performances which occurred multiple times a week. At the end of the 13 weeks, participating athletes were asked to download their personal Oura Ring data. The Oura data points included in this study were used to identify and measure several physiological factors such as menstrual cycle day, …

The Christmas Sisters, A Screenplay, Marybeth Lee Berry

Masters Theses

The Christmas Sisters is a screenplay about the Snow sisters and their father and how love, faith, and family can accomplish to save a beloved tree farm. A Hallmark staple, The Christmas Sisters offers all the comforts of a good Christmas movie but through the lens of a family and sisterly dynamic. By getting to know Holly, Eve, Joy, and Noelle, the true spirit of Christmas shines through, showing the audience that the miracle of the holiday season is found in each other.

Design Of Nanomaterial-Based Sensors For Enhanced Halogen Bonding, Ben H. Edelman, Charles W. Sheppard, Lucas A. Chuidian, Arielle Vinnikov, Felix Bevc, Lillian B. Hughes, Carol A. Parish, Michael C. Leopold

Chemistry Faculty Publications

Halogen bonding is a highly directional, noncovalent, intermolecular interaction which has been harnessed for a variety of applications, including sensor design. A halogen bond (XB) is formed between a region of positive electrostatic potential on a halogen atom (X) and electron rich portions of target molecules. The strength of XB interactions relies on shorter XB bond distances and more linear R–X···B bond angles, which facilitate stronger, more negative binding energies. While prior studies have sought to maximize interactions, few have explored or experimentally demonstrated how geometries and bond angles can enhance XB interactions. Herein, fundamental studies are conducted at self-assembled …

Neuroradiological Features Across Major Psychiatric Disorders And Behavioral Variant Of Alzheimer’S Disease: A Concise Multimodal Synthesis, Sina Dindarian, Joga Chaganti, Nazanin Rafiei, Scott H. Faro

Department of Radiology Faculty Papers

Psychiatric disorders are complex, disabling conditions that continue to rely on subjective diagnostic criteria due to the absence of objective biological markers. Neuroradiology has become a critical discipline for examining the structural, functional, and biochemical underpinnings of these disorders through advanced brain imaging. This review synthesizes findings from five major psychiatric conditions including major depressive disorder, schizophrenia, autism spectrum disorder, obsessive-compulsive disorder, and generalized anxiety disorder, and briefly discusses the behavioral variant of Alzheimer's disease, a variant with neuropsychological overlay, across multiple imaging modalities, including structural magnetic resonance imaging (MRI), diffusion tensor imaging, functional MRI, magnetic resonance spectroscopy, functional near-infrared …

Volumetric Wear Analysis Of Polyethylene Orthopedic Liners Using Point Clouds, Gabriel Landi

Dartmouth College Master’s Theses

In vivo wear of ultra-high molecular weight polyethylene (UHMWPE) orthopedic bearings represents a major problem in shoulder and knee arthroplasty, with significant amounts of devices failing due to the complication itself, and even more due to associated reasons for retrieval, including aseptic loosening. However, quantification of UHMWPE wear has largely been limited to linear and in vitro volumetric analyses, obscuring the understanding of the amount of clinically relevant material loss. This study proposes new methods to measure articular, rim, and backside surfaces of retrieved shoulder and knee UHMWPE liners, centered around the coordinate measuring machine (CMM)-based collection of high density …

Autograft Enlargement After The Ross Procedure In Pediatric Patients: Somatic Growth Or Pathologic Dilatation?, Ioannis Zoupas, Alexander C Mills, Scott D Olson, Damien J Lapar

Faculty, Staff and Student Publications

Purpose of ReviewPulmonary autograft autotransplantation represents a popular surgical approach for pediatric patients requiring aortic valve replacement due to the potential for autograft enlargement to accommodate somatic growth. Nevertheless, autograft dilatation and the subsequent need for reintervention are quite common. Published data suggest that autograft enlargement may result from pathological passive remodeling rather than active somatic growth and vice versa. The present review serves to comprehensively evaluate available evidence related to the fate of the pulmonary autograft after the Ross procedure as it relates to the etiology, risk factors and patterns of autograft failure.ResultsStudies present conflicting results supporting both pathological …

Prevalence And Outcomes Of Her2-Low Versus Her2-0 Status In Patients With Metastatic Breast Cancer, Akshara Singareeka Raghavendra, Diane D Liu, Senthil Damodaran, Sarah Pasyar, Yu Shen, Jason A Mouabbi, Carlos H Barcenas, Kelly K Hunt, Debu Tripathy

Faculty, Staff and Student Publications

Background: HER2-low breast cancer (HER2 immunohistochemical [IHC] score 1+, or IHC 2+ without HER2 gene amplification) is distinct from HER2-positive and HER2-0 breast cancer (IHC 0), with a differing prognosis and specific therapeutic options. The DESTINY-Breast04 trial demonstrated notable efficacy of the HER2 antibody-drug conjugate trastuzumab deruxtecan over standard chemotherapy in patients with metastatic breast cancer (MBC) defined as HER2-low. More recently, the DESTINY-Breast06 trial confirmed this benefit in hormone receptor-positive and HER2-ultralow (less than 1+, but with ≤10% of infiltrating cancer cells showing incomplete and faint/weak membrane staining) cases, prompting re-evaluation of HER2 diagnostic thresholds and treatment strategies.

Methods …

Diet-Responsive Genetic Determinants Of Intestinal Colonization In The Yeast Candida Albicans, Musfirat Shubaita, Mazen Oneissi, Elena Lindemann-Pérez, Cecilia Fadhel Alvarez, Anne-Marie Krachler, Diana M Proctor, J Christian Pérez

Faculty, Staff and Student Publications

Dietary components influence microbial composition in the digestive tract. Although often viewed as energy sources, dietary components are likely to shape microbial determinants of intestinal colonization beyond metabolism. Here, we report that a dietary long-chain fatty acid enhances the yeast Candida albicans colonization of the murine gut partly by eliciting modifications to the fungal cell surface. Mice fed an oleic acid-rich diet were readily colonized by C. albicans and exhibited higher fungal load in feces compared with rodents fed an isocaloric control diet. Surprisingly, β-oxidation, a catabolic process to break down fatty acids for energy production, was dispensable for C. …