Prevalence Of Depression Among Doctors In General Hospitals Of Basrah City Center During The Covid-19 Pandemic, Riham Sabri Saleh, Amaleed Kadhum, Raya Habeeb Abdulimam

Iraqi National Journal of Medicine

Background: Depression is the most common mental disorder in community settings and a major cause of disability worldwide. In 1999, it was the fourth most common cause of disability globally, and by 2020, it is projected to become the second most common cause. Doctors, as the primary workforce in hospitals, endure significant emotional and physical stress, which may have been exacerbated by the COVID-19 pandemic. Aim: This study aimed to estimate the prevalence of depression among doctors during the COVID-19 pandemic and its risk factors. Methods: This descriptive cross-sectional study was conducted from February 1 to June 1, 2021. The …

Clinicopathological Features Of Colorectal Cancer In Young Patients In Comparison With Older Patients, Bahaa Al-Neama, Wasam Al-Asadi

Iraqi National Journal of Medicine

Background:  Colorectal cancer (CRC) has traditionally been considered a disease of older adults; however, recent evidence shows an increasing incidence among younger patients. Understanding the differences in clinicopathological features between young and older individuals is essential for improving early diagnosis, treatment strategies, and outcomes. Aim: The primary objective of this study is to compare the demographic profiles and clinicopathological characteristics of younger patients (aged <40 years) with those of older patients (aged ≥40 years) diagnosed with colorectal cancer. Methods: Eighty-five consecutive patients admitted to our hospital were prospectively followed for their entire hospital stay or up to 7 days, whichever came first. Each patient's blood glucose measurement was recorded according to ward protocol. Indices included total blood glucose per ward, per patient-day, or patient stay, and percentage blood glucose levels per predefined cut points to assess the incidence of hypo-, eu-, and hyperglycemia. The trial registration number at Clinicaltrials.org is NCT04800861. Results: Total data consisted of 645 blood glucose tests from 85 patients and 284 patient-day results, with an average of 2.27 tests per patient-day and 7.59 measurements per patient stay. The percentage of blood glucose in the range (80–180 mg/dL) varied by model, with patient-day showing the highest results at 48.24%, while the percentage of patients with hypoglycemia (blood glucose <60 mg/dL) was highest per patient stay at 1.18%. Conclusions: Younger colorectal cancer patients in this study presented more frequently with rectal tumors, poor differentiation, and advanced disease stages. Despite similar symptom profiles, delayed diagnosis may contribute to worse pathological features. These findings support the need for greater awareness and consideration of earlier screening in younger populations.

Opioid Use After Screw Fixation Of Slipped Capital Femoral Epiphysis., Jonathan R. Warren, Stephanie Coupal, Colleen M. Moreland, Mckenna C. Noe, George E. Quaye, Lisa Berglund, Caleb W. Grote

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Slipped capital femoral epiphysis (SCFE) is a common pediatric hip disorder primarily managed with transphyseal screw fixation. Opioid pain medication is often used postoperatively, but there is little evidence to guide prescribing practices. The purpose of this study was to describe opioid utilization and prescribing practices for patients after screw fixation of SCFE.

METHODS: This was a prospective observational study of patients with SCFE who underwent transphyseal screw fixation. Patients and guardians were contacted on postoperative days 1, 3, and 5 for data collection. Postdischarge analgesic use, pain severity using a parental proxy, and pain control satisfaction were recorded. …

Aberrant Cd25 And Increased Cd123 Expression Are Common In Acute Myeloid Leukemia With Kmt2a Partial Tandem Duplication And Are Associated With Flt3 Internal Tandem Duplication, Qing Wei, Guilin Tang, Shaoying Li, Sa A Wang, Pei Lin, Wei Wang, Sanam Loghavi, Wei J Wang, L Jeffrey Medeiros, Jie Xu

Faculty, Staff and Student Publications

Background: KMT2A partial tandem duplication (PTD) occurs in approximately 5-10% of acute myeloid leukemia (AML) cases and is associated with poor prognosis. While its cytogenetic and molecular features are well described, the immunophenotypic characteristics of AML with KMT2A-PTD remain incompletely defined.

Methods: We identified 47 cases of AML with KMT2A-PTD by optical genome mapping. All cases underwent flow cytometric immunophenotypic analysis and next-generation sequencing using an 81-gene panel.

Results: The cohort included 32 men and 15 women with a median age of 67 years (range, 19-87). Thirty-eight cases were de novo AML, and nine were secondary to myelodysplastic …

Emt-Induced Stem Cell And Mesenchymal Programs Can Be Decoupled Via Cell Division And Esrp1-Dependent Mechanisms, Petra Den Hollander, Maria Castaneda, Suhas V Vasaikar, Joanna Joyce Maddela, Claire Gould, Breanna R Demestichas, Robiya Joseph, Shivangi Agarwal, Abhijeet P Deshmukh, Alvina Zia, Shruti Shah, Tieling Zhou, Geraldine Raja, Paul Allegakoen, Nick A Kuburich, Mika Pietila, Chunxiao Fu, Jeffrey Chang, Chad J Creighton, William F Symmans, Rama Soundararajan, Sendurai A Mani

Faculty, Staff and Student Publications

Epithelial-to-mesenchymal transition (EMT) is known to induce both stemness and mesenchymal properties, and our findings reveal that these two programs can be uncoupled. During EMT, epithelial cells transition from symmetric divisions producing differentiated daughter cells to self-renewing daughter cells. When we block cell division and induce EMT, cells gain mesenchymal properties but not stemness, suggesting the importance of cell division for gaining stemness. We identified ESRP1 as a key regulator of EMT-driven stemness, which get downregulated during EMT in a cell division-dependent manner. Overexpression of ESRP1 prevents the gain of stemness without affecting the mesenchymal program. Only the stemness and …

Role Of The Etv5/P38 Signaling Axis In Aggressive Thyroid Cancer Cells, Jerry H Houl, Rozita Bagheri-Yarmand, Muthusamy Kunnimalaiyaan, Paola Miranda Mendez, Joseph L Kidd, Ali Dadbin, Andrea Ruiz-Jurado, Parag A Parekh, Ying C Henderson, Nikhil S Chari, Aatish Thennavan, Reid T Powell, Clifford C Stephan, Xiao Zhao, Anastasios Maniakas, Roza Nurieva, Naifa L Busaidy, Maria E Cabanillas, Ramona Dadu, Mark Zafereo, Jennifer R Wang, Stephen Y Lai, Marie-Claude Hofmann

Faculty, Staff and Student Publications

Patients with poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) face a much poorer prognosis than those with differentiated thyroid cancers. Around 25% of PDTCs and 35% of ATCs carry the BRAFV600E mutation, which constitutively activates the MAPK pathway, a key driver of cell growth. Although combining BRAF and MEK inhibitors can shrink tumors, resistance often develops. The exact cause of this resistance remains unclear. We previously found that in PDTC and ATC cells, the BRAFV600E mutation is strongly linked to the expression of ETV5, a transcription factor downstream of the MAPK pathway. In the current study, we …

Advances In Targeting Her2 Across Cancer Subtypes: A Pan-Tumor Approach, Taiwo Adesoye, Ecaterina E Dumbrava, Kanwal P S Raghav, Aysegul A Sahin, Hui Chen, Sunyoung S Lee, Milind M Javle, Shubham Pant, Omar Alhalabi, Xiuning Le, Vicente Valero, Paula R Pohlmann, Funda Meric-Bernstam

Faculty, Staff and Student Publications

Human epidermal growth factor receptor 2 (HER2) is an established therapeutic target in multiple solid tumors, particularly breast and gastric cancers. Significant advancements have been made in the development of HER2-targeted therapies, including monoclonal antibodies, tyrosine kinase inhibitors, antibody-drug conjugates (ADC), and novel bispecific antibodies. These agents have revolutionized the treatment landscape for HER2-positive metastatic cancers, resulting in improved progression-free and overall survival, and quality of life for patients. Beyond breast and gastric cancers, HER2 expression/amplification has been observed in other solid tumors, such as colorectal, lung, bladder, ovarian, and biliary tract cancers, offering new opportunities for personalized therapy in …

A Deep Learning-Based Real-Time No-Reference Image Decolorization Network With Perceptual Preservation, Mengjuan Zhao, Yitao Liang, Weiya Shi, Juan Xia

Turkish Journal of Electrical Engineering and Computer Sciences

Currently, grayscale images are preferred as input data for some specific vision tasks. Decolorization is the transformation of a color image into a grayscale image. Efficient decolorization algorithms can improve the overall task efficiency, while perceptual preservation in decolorization can provide more information for further processing. In recent research, traditional methods focus on preserving contrast or detail information with little attention to perceptual features. Deep-learning methods are beginning to consider perceptual preservation, but they run inefficiently. In addition, the decolorization methods lack the optimal target grayscale images for reference. Therefore, we propose a new deep learning-based real-time no-reference decolorization network …

Host-Specific Fluorescence Dynamics In Legume-Rhizobium Symbiosis During Nodulation, Chandan K. Gautam, Gayathri Senanayake, Amanda B. Pease, Mohamed A. Salem, Ahmed H. Rabia, Birgit M. Prüß, Barney A. Geddes

APC Fund Awardees

The legume-rhizobium symbiosis is a cornerstone of sustainable agriculture due to its ability to facilitate biological nitrogen fixation. Still, real-time visualization and quantification of this interaction remain technically challenging, especially across different host backgrounds. In this study, we systematically evaluate the efficacyefficacyefficacyof the nitrogenase system nifH promoter (PnifH) in driving expression of distinct fluorescent reporters; superfolder yellow fluorescent protein (sfYFP), superfolder cyan fluorescent protein (sfCFP), and various red fluorescent proteins (RFPs) within root nodules of determinate (Lotus japonicus-Mesorhizobium japonicum) and indeterminate (Pisum sativum-Rhizobium leguminosarum) systems. We show that PnifH-driven sfYFP and sfCFP yield strong, uniform, and reproducible fluorescence in nodules …

Combining Dna Methylation Features And Clinical Characteristics Predicts Ketamine Treatment Response For Ptsd, Amir Valizadeh, John D Roache, Xinyu Zhang, Ying Hu, Ralitza Gueorguieva, Lynnette A Averill, Mohini Ranganathan, Zuoheng Wang, Douglas E Williamson, Paulo R Shiroma, Matthew J Girgenti, Ismene L Petrakis, Argelio L López-Roca, Stacey Young-Mccaughan, Terence M Keane, Alan L Peterson, Chadi G Abdallah, John H Krystal, Ke Xu

Staff and Researcher Publications

Post-traumatic stress disorder (PTSD) exhibits extensive clinical and biological variability, making treatment challenging. The Consortium to Alleviate PTSD (CAP)-ketamine trial, the largest randomized study of ketamine for PTSD, found no overall benefit of ketamine over placebo, underscoring the necessity to identify responsive subgroups. Using pre-treatment blood DNA methylation profiles and clinical measures from the CAP-ketamine trial, we applied machine learning to predict treatment response. A model based on 1,208 methylation sites achieved higher predictive accuracy than models using clinical variables alone, and combining both data types further improved performance. The methylation-derived score distinguished responders with 92.9% accuracy. The predictive CpGs …

Cold Atmospheric Plasma For Prostate Cancer Therapy—Potential For Clinical Translation, Shengxin Zhang, Janith Wanigasekara, Daniela Boehm, James F. Curtin, Paula Bourke, Tao Zhang, Gemma K. Kinsella

Research Outputs: 2025-Present

Cold atmospheric plasma (CAP) has potential as a new cancer treatment tool due to its room temperature biocompatibility and possible cancer cell selectivity with low side effects. This review examines the current research stage of CAP therapy for Prostate Cancer (PCa) treatment with a focus on CAP device standardization and CAP therapy clinical translation. The current CAP preclinical data is explored through the lens of PCa cellular response, PCa cells selectivity, CAP treatment type and CAP combination therapies. Finally, building on the current preclinical data, this review proposes the potential clinical application methods of CAP at different PCa stages to …

What Is Federalism?: On Piccone's Late Political Philosophy, Robert D'Amico

Fast Capitalism

No abstract provided.

Café Narcissism, Jamie Dangler, Mark P. Worrell

Fast Capitalism

The 1979 Cortland Conference marked a decisive shift in the adventures of Telos by opening up a debate on narcissism that would pave the way for later contests that, in turn, symbolize in the eyes of many, the errant swerve of Marxism and post-Marxist critical theory. In what follows we examine the vibrant theoretical community at Cortland during the late-70s and early 80s, revisit the conference itself, and reflect on the narcissism concept and its relationship to anti-capitalist struggle in a way that is both attuned to debates surrounding the 1979 conference as well as its ongoing relevance for critical …

Absolutizing The Particular, Robert J. Antonio

Fast Capitalism

From the late-1960s to the mid-1980s, Telos brought the Frankfurt School, Western Marxism, and other critical Continental thought to North America and the English speaking world; it was the critical theory organ of that era and best ever English language journal on the topic. Its left lean did not compromise its critical view of communist regimes and left-wing parties and thinkers. Its contribution with regard to critical theories, with Hegelian-Marxist roots, was so substantial and widely acknowledged that many former readers and, I expect, even some journal editors, who have advertised in Telos, during the last 25 years, did not …

Dr. Amy Acton And Levar Burton Discuss Ethics In Public Health, Amy Acton, Levar Burton, Shannon E. French

The International Journal of Ethical Leadership

No abstract provided.

Ruth Coleman Denard (1906-2002): One Of The First Registered Black Occupational Therapists, Mirline Milien

The Open Journal of Occupational Therapy

The experiences and contributions of underrepresented groups in the occupational therapy profession are insufficiently explored and largely absent from occupational therapy education. For instance, the narratives of early Black occupational therapists and students are virtually nonexistent in the literature. As the profession moves toward greater inclusivity, it is essential to uncover these hidden stories and legacies to better understand the profession’s evolution and help shape its future. This article highlights Ruth Coleman Denard, one of the first registered Black occupational therapists in the United States, and provides an overview of her career trajectory. Historical research methods, including a review of …

Enhancing Self-Esteem In Adolescents During Acute Inpatient Psychiatric Hospitalization: A Mixed Methods Study, Praveen Injeti, Julie D. Kugel, Dragana Krpalek, Liane Hewitt, Lida Gharibvand

The Open Journal of Occupational Therapy

Background: Low self-esteem (LSE) can negatively impact adolescent mental health, leading to suicidal ideation (SI). Social stressors, such as peer rejections, are considered a source of stress that can contribute to LSE, SI, and subsequent admission to psychiatric facilities. This study aimed to assess the effectiveness of an occupational therapy intervention to improve self-awareness and self-esteem during short-term hospitalization.

Method: The research used a mixed methods approach to evaluate the impact of a psychoeducational intervention by an occupational therapist on 16 adolescents. The Rosenberg Self-esteem Scale (RSES) was used before the intervention (pretest), immediately after the intervention (posttest …

State Of The Journal: Advancing And Promoting Frames Of Reference For Occupational Therapy Practice, Diane Powers Dirette

The Open Journal of Occupational Therapy

No abstract provided.

Empowerment Pedagogy: A Mixed Methods Grounded Theory Approach To Developing A Pedagogical Framework For Empowering Middle School Aged Students, Henry James Bryant

Educational Studies Dissertations

The current state of adolescent well-being in “post-COVID” America demonstrates a need for widespread intervention to aid students in coping with trauma and mental health issues. In a review of the literature, feelings of empowerment have been found to be antithetical to feelings of trauma. Moreover, the benefits of empowerment in terms of adolescent mental health, academic achievement, and behaviors are well documented. However, strategies designed to impact students’ feelings of empowerment have not been well established, and programs that are presently offered are often inaccessible due to cost, public opinion, and a need for whole school adoption. In this …

Assessing Mindfulness-Based Practices Applications For Use With Incest Survivors With Ptsd And Cptsd, Rosemarie M. Lore

Mindfulness Theses

Abstract

Mindfulness-Based Practices (MBPs) have shown how adverse effects respond in treating symptoms of complex PTSD (CPTSD). There is a lack of research on the impact of (MBPs) upon survivors of incest, a population with an elevated risk of re-traumatization. Professionals must approach MBPs within a multi-modal, trauma-sensitive framework, through psychoeducation, establishment of safety and trust, awareness of Mindfulness-Related Adverse Effects (MRAEs), and developing ways to foster healing. Through a literature review and the current creative project, professionals can use the proposed tool chest to manage MRAEs when treating survivors with CPTSD symptoms. Survivors learn to self-regulate in the face …

Spectator 2026-01-15, Editors Of The Spectator

The Spectator

No abstract provided.

The Role Music Plays In Facilitating Transformation And Self-Actualization In Israeli Music Students Impacted By Trauma, Adina Feldman

Educational Studies Dissertations

Abstract

This qualitative study explores the role music plays in facilitating transformation and self-actualization among Israeli undergraduate and alumni music students who have experienced trauma or post-traumatic stress disorder. Guided by social constructivist and humanistic-existential frameworks, this research employs a narrative methodology to examine how music operates as a medium for meaning-making, resilience, and growth in non-clinical contexts. Data were collected through in-depth interviews, participant observations, and the analysis of musical compositions and artifacts from two singer-songwriters who transformed personal adversity into creative expression. The findings reveal that although trauma leaves lasting psychological and emotional effects, engagement with music enables …

Research Progress In Antagonistic Bacteria Against Staphylococcus Aureus, Caiqi Wang, Yuansong Ma, Xinrui Zhao, Pei Zhou, Sifan Lu, Yuxin Li, Yinbiao Xu

Journal of Food Science and Biotechnology

Staphylococcus aureus,a common Gram-positive foodborne pathogen,is ubiquitous in the human skin and respiratory tract.It can cause pneumonia,pleurisy,endocarditis,food poisoning,sepsis and other infectious diseases.The widespread and long-term use of antibiotics has aggravated the antibiotic resistance of Staphylococcus aureus.In particular,the emergence of multi-drug resistant strains has greatly reduced the therapeutic effect.Therefore,developing new antibacterial means to replace or assist existing antibiotics has become an urgent need.Microbial natural products are important resources for the development of new antibiotics,and antagonistic microorganisms play an important role.This paper reviewed the species of antagonistic bacteria against Staphylococcus aureus,the types of antibacterial active substances,and the commonly used screening methods of …

Probiotics Regulate Gut Microbiota And Immune Homeostasis To Prevent And Treat Food Allergy : A Review, Yao Chen, Zumeng Xia, Yijin Yang, Lianzhong Ai, Guangqiang Wang, Yan Zhang, Zhen Luo, Yong Zhou, Yongjun Xia

Journal of Food Science and Biotechnology

Food allergy (FA) is a common immunological disorder,and its pathogenesis is primarily associated with a complex regulatory process involving CD 4+ T cells in the immune system,such as the polarization of Th 2 cells and the imbalance between Treg/Th 17 cells.The balance of intestinal immune cells plays a critical role in the development of FA,while dysbiosis of the gut microbiota may disrupt this balance,thereby contributing to the onset of FA.Probiotic intervention targeting the gut microbiota can directly or indirectly influence the functions of immune cells to regulate immune responses,representing a promising approach for the prevention and treatment of FA.The authors …

Research Progress Of Gc-Ms-Based Metabolomics In Fermented Cereal Foods, Haichen Liu, Chang Liu, Hongyan Huo, Hui Xu, Shunxi Zhu, Lei Liu, Kui Zou

Journal of Food Science and Biotechnology

As an emerging discipline,metabolomics has gradually become the focus of food science research.Among numerous metabolomics analysis methods,gas chromatography-mass spectrometry (GC-MS ) has attracted much attention for its wide application.Fermented cereal foods occupy an important position in global dietary culture and are an indispensable type of foods in peopl e’s daily lives.The author reviewed the application of GC-MS based metabolomics for the development of fermented cereal foods,covering sample preparation,metabolite extraction,data analysis,and practical application in fermented cereal foods.Moreover,this paper elaborated on the advantages and limitations of GC-MS-based metabolomics in fermentation,aiming to provide a reference for further exploring the principles of food fermentation …

Mechanism Of The Effect Of Microwave Heating On The Degradation Of Fructans In Steamed Cakes Prepared With Saccharomyces Cerevisiae, Xiaoyue Ying, Yuan Tao, Yuan Yuan, Ziting Li, Bowen Yan, Jianxin Zhao, Wei Chen, Daming Fan

Journal of Food Science and Biotechnology

[Objective ] This study aimed to investigate the effect of microwave heating on the fructan mass fraction in steamed cakes prepared with Saccharomyces cerevisiae and elucidate the molecular mechanism of the activation of invertase by microwave.[Method ] Steamed cakes were prepared under varying microwave power density (3.40~5.10 W/g ) and heating time (2~5 min ),and the fructan mass fraction was compared between steamed cakes prepared by microwave heating and conventional steaming.The activity of invertase from Saccharomyces cerevisiae was measured under microwave heating and water bath heating conditions.Molecular dynamics simulations were performed to explore the invertase-kestose interactions under microwave fields.[Result ] …

Differences In Important Chemical Components And Free Radical Scavenging Activities Of The Ginger Germplasm Resources From Fujian, Meichun Chen, Enquan Lin, Xuefang Zheng, Zuliang Li, Bo Liu, Jieping Wang

Journal of Food Science and Biotechnology

[Objective ] This study aims to analyze the important chemical components of different ginger germplasm resources from Fujian and evaluate their comprehensive quality and free radical scavenging activities.[Method ] Gas chromatography-mass spectrometry (GC-MS ) and liquid chromatography-quadrupole-time of flight-mass spectrometry (LC-QTOF-MS ) were employed to determine the importance chemical components in 13 ginger germplasm resources.Differences in the chemical compounds were analyzed by the cluster analysis and principal component analysis (PCA ).The free radical scavenging activities of the ginger germplasm resources against ABTS+ were further evaluated.[Result ] A total of 65 chemical compounds were identified from the 13 ginger germplasm resources,including …

Cyanidin- 3-Glucoside Ameliorates Ocular Surface Dysfunction In Rats With Dry Eye Disease, Ke Zhang, Ziyu Liu, Zhangben Yao, Peng Zhang, Lei Tian, Ying Jie, Yong Wang

Journal of Food Science and Biotechnology

[Objective ] Studies have shown that cyanidin- 3-glucoside (C3G),the main component of black rice anthocyanins,exhibits protective effects on retina and retinal pigment epithelium (RPE ) cells.However,there is a lack of in vivo evidence regarding the efficacy of C 3G in alleviating dry eye disease (DED ),which limits its application in ocular surface disorders.This study aims to investigate the protective effects of C 3G on DED in rats.[Method ] 24 Wistar rats were randomly assigned into control,model,and C 3G groups.In model and C 3G groups,a DED model was established by subcutaneous injection of scopolamine hydrobromide (4 times daily for 28 d).The …

Ultrasound-Assisted Enzymatic Transformation And Immune Efficacy Of Black Ginseng Saponins, Kuo Wang, Bao Zhong, Mingran Luan, Fenglin Li, Zhongkui Lu, Guanran Wang, Kun Yao

Journal of Food Science and Biotechnology

[Objective ] This study aims to elucidate the transformation process of black ginseng saponins and their immunomodulatory mechanisms.[Method ] An ultrasound-assisted enzymatic method was employed for the transformation of black ginseng saponins,and the mass concentration of black ginseng saponins was determined.Furthermore,the immunomodulatory effects of black ginseng saponins were investigated through animal experiments.[Result ] Under the conditions of an enzymatic hydrolysis temperature of 40 ℃,an enzyme mass fraction of 8%,enzymatic hydrolysis time of 60 min,and ultrasonic treatment time of 25 min,the mass concentration of black ginseng saponins increased from 1 615.40 μg/mL to 3 351.38 μg/mL,which represented an increase of 107.47%.The …

Degradation Of Nutrients In Corn Steep Liquor By Aspergillus Oryzae And Absorption Characteristics Of The Product, Xiaojie Wang, Chunrong Xia, Xiaolan Liu

Journal of Food Science and Biotechnology

[Objective ] This study aims to explore the degradation patterns of nutrients in corn steep liquor by Aspergillus oryzae and the absorption characteristics of the product.[Method ] Aspergillus oryzae was used for the fermentation of corn steep liquor,and degradation patterns of nutrients were studied after fermentation for 1,3,5,7,9,and 11 d.Changes in amino acid mass fraction and peptide molecular mass distribution in corn steep liquor after fermentation for 7 d were measured.Furthermore,the resting cells of Auricularia heimuer mycelia were used to explore the absorption characteristics of the fermentation product of corn steep liquor.[Result ] As the fermentation time prolonged within 1~7 …