Digital Commons Network^™

Functional Genomic Analysis Of Non-Canonical Dna Regulatory Elements Of The Aryl Hydrocarbon Receptor, Shayan Shahriar, Tajhal D Patel, Manjula Nakka, Sandra L Grimm, Cristian Coarfa, Daniel A Gorelick

Faculty, Staff and Students Publications

The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor activated by environmental toxicants like halogenated and polycyclic aromatic hydrocarbons, which then binds to DNA and regulates gene expression. AHR is implicated in numerous physiological processes, including liver and immune function, cell cycle control, oncogenesis, and metabolism. Traditionally, AHR binds a consensus DNA sequence (GCGTG), the xenobiotic response element (XRE), recruits coregulators, and modulates gene expression. Yet, recent evidence suggests AHR can also regulate gene expression via a non-consensus sequence (GGGA), termed the non-consensus XRE (NC-XRE). The prevalence and functional significance of NC-XRE motifs in the genome have remained unclear. …

Cordell Young V. John Doe

2026 Decisions

USDC for the Eastern District of Pennsylvania

Development Of Sustainable Economy Programs In Langkat Regency, North Sumatra: Characteristics Of Coastal Communities And Mangrove Utilization, Meilinda Suriani Harefa, Mohamed Abdelwareth, Armin Rahmansyah Nasution, M Taufik Rahmadi, Dwi Irfansyah, Nurul 'Ain

Jurnal Pendidikan Geografi: Kajian, Teori, dan Praktek dalam Bidang Pendidikan dan Ilmu Geografi

Langkat Regency is one of the regencies in North Sumatra with a mangrove forest area of 26,774 hectares in 2024. Mangrove forests offer numerous benefits to coastal communities. Beyond serving as ecosystem resources, mangrove forests also provide economic benefits to coastal residents. Since the 1990s, coastal communities in Langkat Regency have begun cutting down forests for firewood without understanding the potential impacts. If this phenomenon continues, mangrove forest deforestation will worsen. The research aims to identify the characteristics of coastal communities in Langkat Regency, analyze the economic programs favored by these communities, and develop economic program models that sustainably utilize …

Institute For Global Health And Development : Annual 2025, Institute For Global Health And Development

IGHD Newsletters Archives

• Message From the Director
• Workshops & Conferences
• Climate Change and The Built Environment
• Supporting Women in Science (SWIS)
• Field Immersion & Community Engagement
• Global & Regional Engagements
• Climate, Health & Equity Engagements
• Capacity Building & Research Strengthening
• Webinars Hosted by IGHD
• Research Contributions & Global Recognition
• Media Stories, Awards & Achievements
• Policy Advocacy & National Dialogues
• Looking Ahead: Commitment to Equity & Impact
• Shining Light on Achievement
• Climate Change and Maternal Health: Dr. Jai Das Featured in The Economist
• Pakistan Urged to Make Bold Nutrition Pledges
• N4G Summit 2025
• Climate Change Disproportionately Affects Women and Children
• National Seminar Advances Agenda …

Beyond Bile Acids Synthesis: Metabolomics Profiling Highlights Extensive Metabolic Dysregulation And Treatment Response In Ctx, Monte A Del Monte, Jennifer Hanson, Penelope E Bonnen

Faculty, Staff and Students Publications

Background: Cerebrotendinous xanthomatosis (CTX) is an inherited metabolic disorder caused by variants in CYP27A1 leading to loss of sterol-27-hydroxylase activity. Sterol-27-hydroxylase generates two classes of bioactive signaling molecules: bile acids and oxysterols. The broader metabolic consequences resulting from perturbations in bile acid and oxysterol signaling and their reversibility with FDA-approved treatment chenodeoxycholic acid (CDCA), are not fully described.

Methods: To establish a comprehensive map of metabolic consequences of CTX, we performed large-scale, untargeted plasma metabolomics in a single subject with CTX, both before and after 6 months of CDCA therapy, and compared results with a reference cohort of over 1100 …

Comparison Of Three Temperate Rainforest Climate Envelopes For Britain And Ireland: Where Could Our Rainforest Be?, Katerina Chernyuk, Thomas R. Murphy, James Buckley, Mary O'Shaughnessy, Markus P. Eichhorn

School of Biological and Marine Sciences

Restoration of natural habitats is now recognised as a priority in both political and scientific circles. Temperate rainforests are internationally rare and endangered habitats, which are delineated from other woody biomes by high year-round rainfall and moderate temperatures, and are restricted to mid-latitude zones of the globe. With Britain and Ireland harbouring up to 40% of the potential range of European rainforest, this is a crucial region for their protection and restoration. Recent investment in tree planting and restoration initiatives in Ireland and Britain highlight the need for informed planning of native habitat and woodland creation to ensure long-term stability …

Sangkan Paraning Dumadi Sebagai Filosofi Hidup Dalam Puisi-Puisi Sapardi Djoko Damono, Heri Isnaini

Journal of Language, Literature, and Arts

Previous studies on the poetry of Sapardi Djoko Damono have predominantly situated his works within the framework of lyricism, linguistic simplicity, and humanistic reflection, while the dimension of local philosophy as a foundation of existential consciousness has received limited scholarly attention. This article aims to reveal the representation of the concept of sangkan paraning dumadi as a philosophy of life in Sapardi Djoko Damono’s poetry. The concept is understood as an ontological awareness of human existence concerning its origin and ultimate purpose in relation to God. This study employs a philosophical approach using qualitative descriptive analysis of selected poems that …

Rapid Diagnosis Of Staphylococcus Aureus Using The Lamp Method, Hadeel Abdul-Amir, Thair Al-Kelabi

AUIQ Conference Proceedings

Methicillin-resistant Staphylococcus aureus (MRSA), a genetically distinct strain of S. aureus, poses a significant health problem in humans and animals. MRSA is responsible for various difficult-to-treat illnesses in humans and animals. The loop-mediated isothermal amplification (LAMP) experiment was performed using four unique primers developed for six distinct mecA and femA gene sequences. The LAMP test was completed in 45 minutes at 62.5°C and visualized by gel electrophoresis. Moreover, the LAMP test has better sensitivity than conventional PCR, detecting genomic DNA at 64.8 pg/μL, which is hundreds of times more sensitive than conventional PCR.  The LAMP test is an …

Comparison Of The Behavior Of Semiconductor Lasers Under The Influence Of Changing Bias Current With Optoelectronic Feedback, Tareq A. Al Attabi, Salam Jasim Majeed, Muwaffaq Abdullah

AUIQ Conference Proceedings

Direct pump modulation is one feature of semiconductor lasers that sets them apart from other types of lasers. Another degree of flexibility is the injection current disruption. Consequently, instabilities are caused by the disruption of the injection current in semiconductor lasers, and the modulation of the injection current does in fact show instabilities and chaotic behaviors. This research investigates a comparative study between conventional and nanoscale semiconductor lasers. The occurrence of different laser outputs from both types of semiconductor lasers, including the typical output from these devices as well as periodic, multi-periodic, aperiodic, and chaotic ones that arise from injection …

Defective Viral Genomes: Emerging Therapeutic Tools For Animal Viral Infections, Saad Hashem Ghmeiss, Ali Abdul-Jassim Alwan

AUIQ Conference Proceedings

Defective Viral Genomes (DVGs), which are viral genomes that are defective in some way, are naturally occurring byproducts of viral replication in numerous RNA viruses, notably Orthomyxoviridae (Influenza virus), Filoviridae (Ebola and dengue), and Paramyxoviridae (Respiratory Syncytial). They have three well-defined functions: interference with regular virus replication, immunostimulation, and virus persistence. DVGs are defective viral genomes that can hijack the replication cycle of wild-type viruses, leading to partial or complete suppression of viral populations. A variety of new DVGs are created through infection of the host by one of these viruses. The researchers devised a strategy for identifying those most …

Critical Design And The Robotic Imaginary: Design Criticism And Critical Robots, Jörgen Behrendtz

The Journal of Sociotechnical Critique

This paper brings critical design and design criticism to critical robot studies. Critical design can be described as an umbrella term for approaches making use of speculative designs to highlight and challenge narrow assumptions, preconceptions or even taken-for-granted truths about the role products play (in a wide sense) in everyday life. Design criticism refers to a reasoned procedure that investigates emancipatory and/or limiting potentials of designs, theorizes the roles of affordances, materials and embodied perception as epistemological resources in media interaction, and clarifies connections between specific design choices and their associated experiential qualities, seductive powers, ideological underpinnings, material operations, and …

Novel Variants In Jam3 Gene- A Rare Cause Of Early Onset Cns Hemorrhage - First Case Report From India With Review Of Literature, Ashka Prajapati, Manaswini Manaswini, Parth Shah, Nidhi Shah

Journal of Pediatric Neurology

This study provides a systematic review of optic neuritis and neuroretinitis associated with cat scratch disease (CSD) caused by Bartonella henselae. CSD, commonly transmitted through cat scratches or bites, can lead to visual complications, particularly in children, who are more frequently exposed to cats. A comprehensive literature search identified 10 relevant studies from an initial pool of 521 articles. Typical CSD manifests with regional lymphadenopathy, but severe complications like hepatosplenomegaly and encephalitis can occur, especially in younger patients. Atypical presentations, such as neuroretinitis, often begin as optic neuritis with papillary edema, progressing to a macular star pattern. Pediatric patients may …

Psychological Factors And Family Communication In Children And Adolescents With Elimination Disorders, Mehdi Ebrahimi, Hossein Mousavi Nasab, Mehrdad Hosseinpour, Noshirvan Khezri Moghadam

Journal of Pediatric Neurology

Background: Elimination disorders, such as urinary (enuresis) and fecal incontinence (encopresis), involve inappropriate voiding beyond the expected age due to developmental, psychological, or physiological factors. These conditions impact children’s emotional well-being, self-esteem, social functioning, and family relationships. However, few studies have compared psychological functioning and family communication in affected children. This study examines general health, behavioral problems, and mother-child relationships in children with elimination disorders versus healthy peers. Methods: Seventy-two children participated: 25 with urinary incontinence, 24 with fecal incontinence, and 23 healthy controls. Participants were recruited from hospitals in Isfahan. Data were collected using standardized questionnaires: the General Health …

Primary Amoebic Meningoencephalitis (Pam) With Progression To Brain Death Following Naegleria Fowleri Infection In A Teenage Female, Samantha Brener, Stephen Schaffner, Ingrid Y. Camelo, Hasan Samra, Renuka Mehta

Journal of Pediatric Neurology

Background: Naegleria fowleri is a high-temperature freshwater-living amoeba causing PAM by invading nasal epithelium. N. fowleri lives ubiquitously in high-temperature freshwater, but only around 400 cases of PAM have been published worldwide. The mortality rate is 98%. No treatment is 100% effective. Case Presentation: A previously healthy 17-year-old female presented to an urgent care center with fever, headache, sore throat, ear pain, and dizziness. She had swum in freshwater 5 days prior. Her symptoms progressed to altered mental status, photo- and phonophobia, and neck stiffness. Within 4 days, she developed increased intracranial pressure (ICP) and eventually brain death. Two unsuccessful …

Examining Neural Correlates Of Sexual Preferences Between Persian Homo- And Heterosexual Males Using Psychological Assessments And Functional Magnetic Resonance Imaging In Specifying Cognitive Map: A Limited And Cross-Sectional Study, Abdollah Khorshidi

Journal of Pediatric Neurology

Although the brain is an important part of a person’s sexual life, little is known about the correlations between sexual response and brain activation. This study examines brain response through clinical testing to reveal a number of brain structures whose activation are relevant to sexual arousal besides psychological testing according to the common traditional values and standards of Iranian society. Based on initial self-report, 25 homosexual and 25 heterosexual males participated in this test to elucidate the identity and sexual trends via Minnesota Multiphasic Personality Inventory (MMPI-2). Also, an fMRI technique — by presenting distinct homo- and heterosexual sex erotic …

Comprehensive Clinical And Neuroimaging Review Of Posterior Fossa Hemorrhage In Preterm And Term Newborns, Mandy Hsu, Zahra Zhu, Sirajul Islam, Ryan J. Chang, Nouran Hammad, Kalyan C. Bonda, Ermal Aliu, Chintan Gandhi, Gayatra Mainali, Krishnamoorthy Thamburaj, Sunil Naik

Journal of Pediatric Neurology

Posterior fossa hemorrhage (PFH) is a highly morbid condition in preterm and term infants. In this article, we aim to first describe a case of posterior fossa hemorrhage (PFH) and using this example, provide a comprehensive narrative review of the pathophysiology, risk factors, diagnosis, and management of PFH. Management may differ depending on the etiology and based on careful consideration of the risks and benefits of surgical versus conservative management.

Aging In Europe: Implications And Possibilities, Jason L. Powell, Rebecca Steel

Fast Capitalism

No abstract provided.

“No, They’Re Not Digital Natives And They’Re Not Addicted”: An Essay Critiquing Contestable Labels, Nicola F. Johnson

Fast Capitalism

No abstract provided.

The 5 Rs Of Creative Nonfiction, Lee Gutkind

Creative Nonfiction Magazine

No abstract provided.

Keeping Children Safe: Bring Kayden's Law To Ohio, Christina Woods-Tsiperson

Akron Law Review

After decades of punishing murder-suicide headlines, a growing body of evidence now corroborates what female domestic violence survivors have said for years: that family courts deciding child custody cases disproportionately reject mothers’ allegations of domestic violence and paternal child abuse. From prominent legal scholars to local family law attorneys (and increasingly, investigative reporters), many modern voices contend that mothers specifically face a litany of obstacles in court, including heightened judicial suspicion that they are “parental alienators,” a widespread minimization of coercive control, and state legal standards that  emphasize shared parenting over child safety.

Following the widely publicized murder of seven-year-old …

Habitat Destruction: The Where Of Biodiversity Law, Andrew W. Torrance Ph.D., Bill Tomlinson Ph.D.

Akron Law Review

The existence of appropriate habitats is essential to the continued existence of all species with which humans share the Earth. However, humans are currently enacting changes around the globe--anthropogenic environmental disruption--that threaten the habitats of many species. In this article, we first summarize existing habitat-related law in various countries, including legal designation of areas for protection (e.g., national parks), laws that enable conservation organizations to purchase but not utilize development rights, and international treaties such as the Convention on Biological Diversity or the Ramsar Convention on Wetlands of International Importance. We then propose a suite of novel approaches …

Royal Crown, Bret Lott

Creative Nonfiction Magazine

No abstract provided.

A Case Report Of Shwachman-Diamond Syndrome And Literature Review, Xinfeng Gao, Jizhong Wang

Journal of Pediatric Genetics

Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive genetic disorder, with approximately 90% of cases caused by pathogenic variants in the SBDS gene. This report describes a case of SDS diagnosed during the management of acute appendicitis. The patient, a male aged two years and 11 months, was admitted for emergency surgery for acute appendicitis. Subsequent evaluation revealed pancreatic exocrine dysfunction, pancreatic steatosis, abnormal liver function, and a history of recurrent diarrhea and neutropenia. Next-generation sequencing identified compound heterozygous SBDS variants: NM_016038.2:c.183_184TA>CT (p.Lys62*) and NM_016038.2:c.258+2T>C. This case highlights the importance of considering SDS in children presenting with recurrent …

Taming Psoriatic Inflammation: Targeting The Inos–Oxidative Stress–Necroptosis Axis For Precision Therapy, Tolulope Omotope Omolekan, Tithi Roy, Jean Christopher Chamcheu

Faculty Publications

Necroptosis is increasingly recognized as a central driver of psoriatic inflammation, promoting keratinocyte death and sustaining immune activation. Recent evidence shows that inducible nitric oxide synthase (iNOS) deficiency and exogenous nitric oxide (NO) supplementation ameliorate psoriasis-like dermatitis in mice by reducing oxidative stress and constraining necroptotic signaling. These findings identify iNOS-derived NO as both a mediator of reduction–oxidation (redox) imbalance and a key regulator of necroptosis, thereby advancing mechanistic insight into psoriatic pathogenesis. Importantly, they highlight the iNOS–oxidative stress–necroptosis axis as a translationally actionable therapeutic target. Modulating necroptotic cell death through NO-based interventions may restore epidermal homeostasis and improve clinical …

Stress And Emotion Regulation In U.S. Undergraduate Students: A Theoretical And Narrative Review, Joshua Ross Pilchik

ETD Collection

Everyone experiences stress, but young adulthood brings some of the most intense and impactful stressors people face in their entire lives. For U.S. undergraduate students, persistent academic, financial, and social demands are ever-present, concurrent with a niche developmental period marked by identity exploration, assumption of new life roles, and growing autonomy (Arnett, 2000, 2015). Emotion regulation guides the ways people influence which emotions they have, when they have them, and how they experience or express them (Gross, 1998, 2015). Emotion regulation acts as a cornerstone for how students interpret and respond to these stressors (Compas et al., 2014; Aldao, 2013), …

Trapped And Traumatised: A Scoping Review Of The Psychological Sequelae Of Entrapment Following Motor Vehicle Collision, Thomas A.M. Dixon, Kara Hole, Louise Johnson, Tim Nutbeam

Peninsula Medical School

Background: Motor vehicle collisions (MVCs) are a significant public health challenge, resulting in substantial mortality and morbidity. Entrapment occurs in 12–33% of all MVCs and is associated with greater injury severity, longer on-scene time, and increased mortality. However, the psychological consequences of entrapment remain poorly characterised. Objectives: This scoping review seeks to establish the current understanding of the psychological sequelae of entrapment following MVCs and draws on insights from related fields of study in order to inform future research and clinical practice. Methods: A scoping review was undertaken following established methodological guidance. Searches were completed on NHS Knowledge and Library …

Prediction Of Outcome From Spatial Protein Profiling Of Triple-Negative Breast Cancers., Ali Foroughi Pour, Te-Chia Wu, Javad Noorbakhsh, Jan Martinek, Santhosh Sivajothi, Paul Robson, Karolina Palucka, Jeffrey Chuang

Faculty Research 2026

BACKGROUND: In tumors, reciprocal spatial interactions between immune cells, their mediators, the extracellular matrix, and mutated neoplastic cells impact all aspects of treatment resistance. The operational mechanisms of these interactions are foundational for developing insights and targets for cancer therapy and prevention. Spatial quantification of the tumor microenvironment system from image data has untapped potential for patient stratification.

METHODS: Here, we present SparTile, a powerful computational approach for the analysis of multiplex proteomics images to reveal clinically relevant structural organization in the tumor microenvironment. SparTile enables robust and unbiased identification and characterization of tumor microenvironments based on spatial relationships among …

Prediction Of Outcome From Spatial Protein Profiling Of Triple-Negative Breast Cancers., Ali Foroughi Pour, Te-Chia Wu, Javad Noorbakhsh, Jan Martinek, Santhosh Sivajothi, Paul Robson, Karolina Palucka, Jeffrey Chuang

Faculty Research 2026

BACKGROUND: In tumors, reciprocal spatial interactions between immune cells, their mediators, the extracellular matrix, and mutated neoplastic cells impact all aspects of treatment resistance. The operational mechanisms of these interactions are foundational for developing insights and targets for cancer therapy and prevention. Spatial quantification of the tumor microenvironment system from image data has untapped potential for patient stratification.

METHODS: Here, we present SparTile, a powerful computational approach for the analysis of multiplex proteomics images to reveal clinically relevant structural organization in the tumor microenvironment. SparTile enables robust and unbiased identification and characterization of tumor microenvironments based on spatial relationships among …

Cover And Contents

Turkish Journal of Botany

No abstract provided.

Effects Of Hydro- And Nano-Priming Treatments On Seed Germination And Metabolism In Sugar Beet (Beta Vulgaris L.), Sarah Jorjani, Ömer Can Ünüvar, Songül Gürel, Ekrem Gürel

Turkish Journal of Botany

This study examined the effects of hydropriming and nanopriming on the germination and physiological parameters of sugar beet seeds. Seeds were treated with distilled water as a traditional method and with TiO2 nanoparticle solutions at concentrations of 5, 10, and 15 ppm as an advanced method. Seeds were soaked for 3, 6, and 9 h, followed by postpriming maintenance for 10 and 45 days. T he results indicated no statistically significant differences in germination rates between the control and primed groups. Both priming methods markedly increased alpha-amylase activity and chlorophyll content, indicating improved metabolic and photosynthetic potential. Notably, nanopriming for …