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Roadblocks To Retention In Teacher Education Programs, Tamara Pack, Tod Kenney, Carol Hoyle Mar 2026

Roadblocks To Retention In Teacher Education Programs, Tamara Pack, Tod Kenney, Carol Hoyle

Teacher Education Journal of South Carolina

This study reviewed student performance outcomes of two cohorts of preservice teacher candidates to identify the factors that contribute to attrition in a university teacher preparation program. A quantitative analysis of Grade Point Averages (GPAs) suggests that low grades in general education courses may negatively impact a candidate’s self-efficacy towards completing the high stakes testing requirement of the Praxis Core exam and therefore serve as early indicators. Proactive measures to address systemic roadblocks are shared.


The Unlikely Outcome Of A Struggling Kindergartner: A Cognitive Rags-To-Riches Tale, Amanda M. Butler Mar 2026

The Unlikely Outcome Of A Struggling Kindergartner: A Cognitive Rags-To-Riches Tale, Amanda M. Butler

Teacher Education Journal of South Carolina

Despite teachers’ implementation of research-based strategies, many students fail to make adequate progress. In some cases, this stems from a neurophysiological response that is beyond the teacher’s and student’s control. Drawing on Maslow’s hierarchy of needs, unintended findings from a previous study illuminate a larger, deeply convoluted issue that will promote unique conversations in education circles. These findings bear significant discoveries that could alter the trajectory for failing students and elevate the teaching profession.


Full Issue: Volume 15, Number 1, Fall 2021, Judy Beck, Susan Fernandez Mar 2026

Full Issue: Volume 15, Number 1, Fall 2021, Judy Beck, Susan Fernandez

Teacher Education Journal of South Carolina

This file contains the full issue of TEJSC, including front matter, table of contents, editorial notes, and articles.


Face-To-Face Or Cyberspace? The Evolution Of Science Inquiry Professional Development And The Impact Of Teacher Attitudes About New Curriculum, Kimberly Carroll Mar 2026

Face-To-Face Or Cyberspace? The Evolution Of Science Inquiry Professional Development And The Impact Of Teacher Attitudes About New Curriculum, Kimberly Carroll

Teacher Education Journal of South Carolina

Today's students often have choices in the way they learn new things. When choices are given, attitudes about learning often improve. What happens when teachers are given choices? This article provides the research data of a pilot study conducted with grades three through eight science teachers regarding their preferred method of professional development. Using the Revised Science Attitude Scale, (RSAS), (Bitner, 1994, Thompson & Shrigley, 1986), the researcher determined the mode of professional development type (face-to-face vs online) resulted in no impact on teacher attitudes about teaching science inquiry. Results support a null hypothesis and provide significant information for determining …


Full Issue: Volume 9, 2016, Christopher Burkett Mar 2026

Full Issue: Volume 9, 2016, Christopher Burkett

Teacher Education Journal of South Carolina

This file contains the full issue of TEJSC, including front matter, table of contents, editorial notes, and articles.


Transitioning To Act Standards In South Carolina Schools: Insights And Techniques For School Districts, Howard V. Coleman, Jeremy Dickerson, Cindy Ambrose, Edi Cox, Dottie Brown Mar 2026

Transitioning To Act Standards In South Carolina Schools: Insights And Techniques For School Districts, Howard V. Coleman, Jeremy Dickerson, Cindy Ambrose, Edi Cox, Dottie Brown

Teacher Education Journal of South Carolina

The adoption of ACT Standards in South Carolina for the 2015/2016 school year is requiring rapid and systemic change for teachers, local school leaders, district administrators, and university teacher/administrator preparation programs. This article presents descriptions of the new standards and assessments, provides an overview of the current transition to ACT Standards, and emphasizes the importance of planning and implementing relevant, high quality professional development for teachers and local school leaders. The article concludes with examples of techniques from the Horry County Schools ACT planning and implementation process.


The Science Edtpa: Emphasis On Inquiry, D. Michelle Rogers, Lisa Barron Mar 2026

The Science Edtpa: Emphasis On Inquiry, D. Michelle Rogers, Lisa Barron

Teacher Education Journal of South Carolina

edTPA is a performance-based assessment used to evaluate the teaching skills of pre-service teacher candidates. The Middle Childhood Science and Secondary Science edTPA assessments require that students are engaged in specific skills of scientific inquiry. While inquiry has been a focus of science education reform at the national level for years, there is little evidence to show that inquiry is common in the K-12 classroom. This article explains what inquiry is, why it is valuable, and why its inclusion poses a challenge and opportunity for new teachers being assessed with edTPA. The authors also provide suggestions to help college faculty …


Examining The Effects Of Professional Development On Students’ Attitudes, Experiences With Inquiry, And Content Knowledge, Michelle Cook Mar 2026

Examining The Effects Of Professional Development On Students’ Attitudes, Experiences With Inquiry, And Content Knowledge, Michelle Cook

Teacher Education Journal of South Carolina

Professional development for in-service teachers is an issue of statewide and national concern. This study is part of a larger research project that investigates the effects of a professional development experience on high school biology teachers' content knowledge, teaching efficacy, and ability to develop and implement inquiry-based instruction, as well as student performance and interest in science. This study specifically focuses on data collected from high school students taking biology from teachers involved in the professional development. Pre-and post measures on the Attitutes Towards Science Inventory and on a survey used to characterize experiences with practices associated with inquiry were …


Cbx6-Ca9 Axis: An Epigenetic-Metabolic Vulnerability In Glioblastoma, Keykavous Parang Mar 2026

Cbx6-Ca9 Axis: An Epigenetic-Metabolic Vulnerability In Glioblastoma, Keykavous Parang

Pharmacy Faculty Articles and Research

Glioblastoma (GBM) remains one of the most therapeutically recalcitrant malignancies, with median survival rarely exceeding 15 months despite maximal therapy.1 The hypoxic tumor microenvironment drives treatment resistance through epigenetic and metabolic adaptations.2

In this issue of Molecular Therapy Oncology, the study by Wang et al.3 demonstrates a novel regulatory axis between CBX6 (chromobox 6), a polycomb group protein, and CA9 (carbonic anhydrase 9), revealing how hypoxia-driven epigenetic reprogramming promotes tumor progression and identifying a mechanistically linked pathway for therapeutic intervention in GBM.

The study by Wang et al.3 advances our understanding of how the tumor microenvironment …


Predictive Reliability Assessment And Profit Optimization Of An Ice Cream Plant Using An Artificial Neural Network Technique, Akash Tewatia, Surbhi Gupta, Manju Kashyap, Archana Chauhan Mar 2026

Predictive Reliability Assessment And Profit Optimization Of An Ice Cream Plant Using An Artificial Neural Network Technique, Akash Tewatia, Surbhi Gupta, Manju Kashyap, Archana Chauhan

Baghdad Science Journal

This study presents a reliability analysis of an ice cream manufacturing facility based on operational failure data. The research develops a ten-component system model that captures plant dynamics and organizes it into three subsystems to reduce computational complexity. The study derives key reliability parameters and constructs a state transition diagram to represent system behavior across multiple operating states. The analysis applies an Artificial Neural Network (ANN) to address the limitations of conventional analytical methods in modeling complex nonlinear systems. The ANN provides strong predictive performance and manages uncertainty within the operational environment. The proposed framework estimates system reliability with high …


Fisheries Occasional Publication No. 151 - Response To 2025 External Review Of Integrated Stock Assessments For Key Wa Demersal Indicator Stocks, Brett Crisafulli, Emily A. Fisher, Matias Braccini, Rubie Evans-Powell, Fabian I. Trinnie, Ainslie Denham, S. A. Hesp Mar 2026

Fisheries Occasional Publication No. 151 - Response To 2025 External Review Of Integrated Stock Assessments For Key Wa Demersal Indicator Stocks, Brett Crisafulli, Emily A. Fisher, Matias Braccini, Rubie Evans-Powell, Fabian I. Trinnie, Ainslie Denham, S. A. Hesp

Fisheries Occasional Publications

Consistent with national trends, the Department of Primary Industries and Regional Development (DPIRD) is transitioning to the globally recognised Stock Synthesis (SS) platform to support more robust, transparent, and internationally aligned assessments. To ensure this transition remains scientifically sound, DPIRD commissioned an independent expert review in 2025, following a previous review in 2024. The 2025 review was conducted by Professor André Punt and focused on integrated models for three key WA fish stocks: red emperor in the Kimberley, WA dhufish in the southern West Coast Bioregion, and sandbar shark at the statewide level. This publication summarises the findings and recommendations …


Investigation Of Molecular Footprints In Ultra-High Diluted Homoeopathic Solutions Of Arnica Montana And Rhus Toxicodendron Through Combined Infrared And Impedance Spectroscopy, Sharbadeb Kundu, Usha Rani Dash, Chirasree Roychaudhuri, Aindrila Roy, Sanatan Chattopadhyay, Rathin Chakravarty, Debadatta Nayak, Subhash Kaushik, Amit Roy Chowdhury, Ananya Barui, Subhadip Chakraborty Mar 2026

Investigation Of Molecular Footprints In Ultra-High Diluted Homoeopathic Solutions Of Arnica Montana And Rhus Toxicodendron Through Combined Infrared And Impedance Spectroscopy, Sharbadeb Kundu, Usha Rani Dash, Chirasree Roychaudhuri, Aindrila Roy, Sanatan Chattopadhyay, Rathin Chakravarty, Debadatta Nayak, Subhash Kaushik, Amit Roy Chowdhury, Ananya Barui, Subhadip Chakraborty

Indian Journal of Research in Homoeopathy

Background: The study of ultra-high diluted (UHD) solutions is a compelling and controversial domain in modern science. Despite numerous investigations and hypotheses, there is a lack of rigorous, reproducible empirical evidence supporting the existence of molecular footprints beyond the Avogadro's limit. Objective: This study conducted a detailed investigation of the molecular and electrical properties, focusing on hydrogen bonding and impedance to understand the fundamental nature of UHD solutions. Materials and methods: Combined impedance and infrared spectroscopic investigations were performed to probe the structural behaviour of relevant water networks at the molecular level of UHD alcoholic extract of Arnica montana (AM) …


Mitochondria-Mediated Apoptotic Induction By Chionanthus Virginica Q: A Cytotoxic And Oxidative Stress-Driven Approach In Hepg2 Hepatocellular Carcinoma Cells, Arun R. Nair, Venkateshan Hariram, Vettrivel Arul Mar 2026

Mitochondria-Mediated Apoptotic Induction By Chionanthus Virginica Q: A Cytotoxic And Oxidative Stress-Driven Approach In Hepg2 Hepatocellular Carcinoma Cells, Arun R. Nair, Venkateshan Hariram, Vettrivel Arul

Indian Journal of Research in Homoeopathy

Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, with current therapeutic options limited by late-stage detection, recurrence, and toxicity. Alternative treatments derived from medicinal plants are gaining attention due to their potential anticancer properties. Chionanthus virginica, traditionally used for liver disorders, contains bioactive compounds with hepatoprotective and antioxidant effects. However, its anticancer potential remains largely unexplored. Objective: This study evaluates the antioxidant, cytotoxic, and apoptotic effects of Chionanthus virginica in mother tincture (Q) and potentised (12C) forms on HepG2 liver cancer cells to determine its efficacy as a natural anticancer agent. Materials and methods: HepG2 …


Research Highlights, Meenu Gupta, Sunaina Shanker Mar 2026

Research Highlights, Meenu Gupta, Sunaina Shanker

Indian Journal of Research in Homoeopathy

NA


Fundamental Research Principles In Homoeopathy: Bridging Empirical And Clinical Evidence, Himanshu Shekhar, Parth Aphale, Shashank Dokania Mar 2026

Fundamental Research Principles In Homoeopathy: Bridging Empirical And Clinical Evidence, Himanshu Shekhar, Parth Aphale, Shashank Dokania

Indian Journal of Research in Homoeopathy

Letter to Editor


Supplemental Data For Gulf Coast Walleye Edna Survey, Kevin W. Jones Mar 2026

Supplemental Data For Gulf Coast Walleye Edna Survey, Kevin W. Jones

Research Data

This file contains the full eDNA collection and amplification dataset for:

Jones, K.W. (2026). Development and application of an eDNA protocol for the detection of Gulf Coast Walleye (Sander vitreus) in Mississippi [Thesis submitted for publication]. Department of Wildlife, Fisheries, and Aquaculture, Mississippi State University.


Friendship In Scriptural Reasoning: Reframing Goodson's "Relational Dynamics", Jim Fodor Mar 2026

Friendship In Scriptural Reasoning: Reframing Goodson's "Relational Dynamics", Jim Fodor

Journal of Scriptural Reasoning

No abstract provided.


The Evolution Of Self-Awareness In Conscious Organisms, Robert A. Dielenberg Mar 2026

The Evolution Of Self-Awareness In Conscious Organisms, Robert A. Dielenberg

Journal of Conscious Evolution

Self-awareness in conscious organisms remains an enduring puzzle for philosophers and neuroscientists. This paper proposes a tripartite evolutionary model tracing its emergence through three sequential types: the sensory self (primitive egocentric, valence-tagged awareness of sensory states), the bodily self (external objectification of the body as a distinct entity, evidenced by mirror self-recognition in select species), and the cognitive self (internal objectification of the mind enabling recursive self-transformation). Adopting a monist framework, the model treats consciousness as the biological substrate of delayed neural apperception (the “Delayed Present”), within which selves emerge as increasingly sophisticated models. It distinguishes non-human metacognition—implicit, online regulation—from …


Mentoring Mentalities Made Manifest: Toward A Better Understanding Of Secondary Teacher Mentor Professional Learning, Practice, And Self-Efficacy, Maggie L. Wilson Mar 2026

Mentoring Mentalities Made Manifest: Toward A Better Understanding Of Secondary Teacher Mentor Professional Learning, Practice, And Self-Efficacy, Maggie L. Wilson

USF Tampa Graduate Theses and Dissertations

Teacher shortages are becoming increasingly problematic nationwide. Teacher mentoring has been found to be an effective method of curbing teacher attrition, but little attention has been addressed to ensuring that teacher mentors are receiving the most relevant professional learning experiences to bolster their self-efficacy and mentoring practice. This qualitative study, drawing on research traditions such as grounded theory and case study, seeks to illuminate the mentor self-efficacy and practice of secondary teacher mentors and to understand the role their professional learning plays in how and how well they enact their mentor roles. Through qualitative interviews, including artifact-based interviews, this study …


Scarcity Rewritten: Revenue Tracking As A Catalyst For Growth Mindset And Financial Control, Christian M. Pearson Mar 2026

Scarcity Rewritten: Revenue Tracking As A Catalyst For Growth Mindset And Financial Control, Christian M. Pearson

Undergraduate Honors Theses

While revenue tracking is a widely recognized “best practice” for businesses in developed economies, it is far from a universal practice. In Cambodia and other emerging markets, many small business owners do not track revenue or expenses, which may limit their ability to make sound financial decisions and reinforce psychological responses consistent with chronic resource scarcity. This article examines the effects of a business support intervention in which Cambodian business owners participated in an 8-week program designed to help them calculate profits by tracking revenue, variable costs, and fixed costs. Findings from a randomized field experiment show that business owners …


Quantifying Regional Variation Of Lipid Metabolism In The Brain, Martin D. Sorensen Mar 2026

Quantifying Regional Variation Of Lipid Metabolism In The Brain, Martin D. Sorensen

Undergraduate Honors Theses

Apolipoprotein E gene (APOE) and its associated isoforms are the most significant genetic risk factors for Alzheimer’s disease (AD). The common alleles, APOE2/3/4, exhibit a protective/neutral/risk-inducing impact on sporadic AD development respectively. Our lab’s research focuses on APOE modification of the brain proteome and lipidome, with an emphasis on regional regulation and interest in assessing how APOE4 affects regulation differently between distinct regions of the brain. This thesis presents an analysis of cryosectioned brain samples harvested from young APOE knock-in mice. Using metabolic labeling with deuterated water, we measure turnover and dietary sourcing of lipids. We observe significant differences in …


Holistic Approach Of Homoeopathy In Treatment Of Multimorbidity: A Case Report, Divya Verma, Nitin Kumar Saklani, Arun Kumar Mar 2026

Holistic Approach Of Homoeopathy In Treatment Of Multimorbidity: A Case Report, Divya Verma, Nitin Kumar Saklani, Arun Kumar

Indian Journal of Research in Homoeopathy

Introduction: Multimorbidity, a rise in all ages, is a challenge for health care systems that are focused on single-disease management. Homoeopathy has shown competence in the management of chronic diseases, whether they occur as a single ailment or as multimorbidities. Case Summary: A 25-year-old female suffering from symptoms of PCOS, like irregular menses, secondary dysmenorrhea and secondary amenorrhea, along with chronic migraine visited the OPD. She also developed renal calculi during the previous homoeopathic treatment. Her condition improved through homoeopathic medicines Pulsatilla and Lycopodium. The case is reported according to HOM-CASE guidelines. The assessment of causal attribution of homoeopathic …


Biogasification Potential Of Medium- To High-Rank Coals And Its Controlling Mechanisms At A Molecular Structural Level, Bao Yuan, Li Jiajun, Li Dan, Chen Xueru, Wang Xiaojing Mar 2026

Biogasification Potential Of Medium- To High-Rank Coals And Its Controlling Mechanisms At A Molecular Structural Level, Bao Yuan, Li Jiajun, Li Dan, Chen Xueru, Wang Xiaojing

Coal Geology & Exploration

Objective Coals with varying metamorphic grades differ significantly in the potential for methane generation through microbial degradation. Medium- to high-rank coals can generate a substantial volume of methane through microbial degradation. However, key factors governing their biogasification potential remain poorly understood. This study aims to identify the dominant factors controlling the potential of medium- to high-rank coals for methane generation through microbial degradation, as well as relevant controlling mechanisms, from the perspective of molecular structures.Methods The Carboniferous-Permian medium- to high-rank coals along the eastern margin of the Ordos Basin were investigated in this study. Using experiments on the hydrocarbon …


Multi-Modal Tensor Fusion For Alzheimer’S Disease Recognition, Mason Li, Tiffany Le, Jiajing Huang, Yuxin Wen Mar 2026

Multi-Modal Tensor Fusion For Alzheimer’S Disease Recognition, Mason Li, Tiffany Le, Jiajing Huang, Yuxin Wen

Engineering Faculty Articles and Research

Accurate and early diagnosis of Alzheimer’s disease (AD) is critical for effective intervention, disease monitoring, and patient care. Traditional diagnostic approaches rely on a single modality, such as clinical assessments, neuroimaging, or genetic markers, which may fail to capture the complex, multifaceted nature of AD. Multimodal learning has therefore been explored to integrate complementary information across data sources. However, conventional fusion strategies, including early feature concatenation and late decision-level fusion, often model modalities independently and fail to capture high-order cross-modal interactions. To address these limitations, we propose a multimodal tensor fusion network (MTFN) that integrates heterogeneous data sources, including visual …


Qualitative Versus Quantitative Analysis Of Entheses: Using An Ordinal Scale And 3d Scanned Metrics To Understand Entheseal Differences In The Charity Hospital Cemetery (16or108), Gillian Stewart Mar 2026

Qualitative Versus Quantitative Analysis Of Entheses: Using An Ordinal Scale And 3d Scanned Metrics To Understand Entheseal Differences In The Charity Hospital Cemetery (16or108), Gillian Stewart

LSU Master's Theses

Using a sample from New Orleans’ Charity Hospital Cemetery (16OR108), an analysis between ordinal scores and digital quantitative analysis (DQA) measurements of the entheses (muscle attachment sites) was performed. The skeletal elements (n = 235) examined were the humerus, radius, femur, and tibia. The entheses were 3D scanned using an Artec Space Spider scanner and processed with the Artec Studio Professional© v.2018 and Geomagic Wrap® v.2021 software. Entheses were analyzed by: left and right sides, male and female, and distribution of scores across elements. The analyses yielded significant differences between proliferative and erosive score distribution. Scores between elements exhibited variation. …


What Does Next-Generation Mass Spectrometry Offer For Proteomics? A Comprehensive Platform Comparison, Filipa Blasco Tavares Pereira Lopes, Daniela Schlatzer, Tara Sudhadevi, Anantha Harijith, Marzieh Ayati, Mehmet Koyutürk, Mark R. Chance Mar 2026

What Does Next-Generation Mass Spectrometry Offer For Proteomics? A Comprehensive Platform Comparison, Filipa Blasco Tavares Pereira Lopes, Daniela Schlatzer, Tara Sudhadevi, Anantha Harijith, Marzieh Ayati, Mehmet Koyutürk, Mark R. Chance

Computer Science Faculty Publications

Next-generation mass spectrometry platforms (Orbitrap Astral, timsTOF Ultra) are reshaping proteomics by enhancing analytical depth and sensitivity. We compared these platforms against Orbitrap Exploris 480 using neonatal mouse lung tissues from a bronchopulmonary dysplasia model (n = 12), employing four acquisition strategies: Exploris 480 DDA/DIA, Astral HR-DIA, and timsTOF Ultra DIA-PASEF. All platforms identified ∼4000 proteins in common, with 98% proteome coverage of data-dependent acquisition (DDA) identifications using data-independent (DIA) methods and 92% concordance between next-generation systems. Orbitrap Astral and timsTOF Ultra quantified >225,000 peptides and 13,000 proteins, representing ∼800% and ∼300% greater depth than Exploris 480 DDA, respectively. …


Discovery Of Quasi-Carbon Nanotube Structures In Tectonically Deformed Coals And Their Formation Mechanisms, Li Yunbo, Wang Rongqi, Song Dangyu, Wang Chengtao, Li Qiang, Yi Ke, Wang Yuanyuan, Pan Jienan Mar 2026

Discovery Of Quasi-Carbon Nanotube Structures In Tectonically Deformed Coals And Their Formation Mechanisms, Li Yunbo, Wang Rongqi, Song Dangyu, Wang Chengtao, Li Qiang, Yi Ke, Wang Yuanyuan, Pan Jienan

Coal Geology & Exploration

Objective Carbon nanotubes (CNTs) have attracted wide attention due to their unique structures and performance. However, their artificial synthesis requires stringent conditions, including high temperatures (700 ℃ to 2 300 ℃), stable carbon sources, and catalysts. Furthermore, these structures are rarely discovered in nature. As a carbon-rich medium, coals can form a variety of ordered carbon structures during their metamorphic and deformational processes, serving as an ideal carrier for exploring the formation mechanisms of natural CNTs.Methods Typical tectonically deformed coals from the Pingdingshan and Huaibei mining areas were investigated in this study. After demineralization and chloroform extraction, coal samples …


Spatiotemporal Variations And Their Influencing Factors For Vegetation Net Primary Productivity In The Shendong Coal Base, Yang Fei, Cui Kuankuan, Zhang Chengye, Li Jun, Dong Qiulin Mar 2026

Spatiotemporal Variations And Their Influencing Factors For Vegetation Net Primary Productivity In The Shendong Coal Base, Yang Fei, Cui Kuankuan, Zhang Chengye, Li Jun, Dong Qiulin

Coal Geology & Exploration

Objective The Shendong coal base, located within the arid and semi-arid regions in western China, is identified as the region with the most pronounced contradiction between coal resource development and ecological conservation in the country. Analyzing the spatiotemporal variations in the ecosystem and their influencing factors at the base scale provides a necessary foundation for green mine construction while also offering critical support for regional sustainable development.Methods In this study, the vegetation net primary productivity (NPP) was selected as an indicator for the ecological evaluation of mining areas. By integrating data on terrain, weather and climate, socio-economy, and human …


Soil Microbial Biomass And Organic Carbon Fractions Under Different Natural Restoration Years In Arid Coal Mining Subsidence Areas In Xinjiang, China, Xiao Li, Bi Yinli, Wang Dongdong, Li Jianfeng, Gong Hanlin, Deng Aojuan, Hou Wensheng Mar 2026

Soil Microbial Biomass And Organic Carbon Fractions Under Different Natural Restoration Years In Arid Coal Mining Subsidence Areas In Xinjiang, China, Xiao Li, Bi Yinli, Wang Dongdong, Li Jianfeng, Gong Hanlin, Deng Aojuan, Hou Wensheng

Coal Geology & Exploration

Objective This study aims to elucidate the influence of the natural restoration process on changes in soil microbial biomass and organic carbon fractions in coal mining subsidence areas. This effort will provide a crucial scientific foundation for understanding the natural ecological restoration process and carbon accumulation dynamics in arid coal mining subsidence areas.Methods Arid coal mining subsidence areas in Xinjiang, China were investigated in this study. Using the space-for-time substitution approach, sample plots were selected from an unmined area and areas having undergone natural restoration for one, three, eight, and 12 years. Subsequently, systematic analyses were conducted on the …


Mdm4 At The Crossroads: Beyond P53 And Mdm2., Dipesh Thapa, Allison St John, Alejandro Parrales, Atul Ranjan, Tomoo Iwakuma Mar 2026

Mdm4 At The Crossroads: Beyond P53 And Mdm2., Dipesh Thapa, Allison St John, Alejandro Parrales, Atul Ranjan, Tomoo Iwakuma

Manuscripts, Articles, Book Chapters and Other Papers

MDM4 (Murine Double Minute 4), also known as MDMX, is a crucial negative regulator of the tumor suppressor p53. MDM4 heterodimerizes with MDM2 to enhance MDM2-mediated ubiquitination and degradation of p53, thereby promoting tumorigenesis. Beyond its canonical role in inhibiting p53 activity, recent studies have revealed diverse p53-independent functions. MDM4 interacts with various proteins, including p73, E2F1, casein kinase 1α, PPARα, and TRIM21 to regulate cell cycle progression, β-catenin-mediated pre-leukemic progression, and ferroptosis independent of p53. In addition, MDM4 functions independently of both p53 and MDM2 by interacting with proteins, such as SMAD family members 3/4, retinoblastoma protein (pRB), p21, …