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Gardner-Webb Professor And Student Present Papers At International Meeting, Office Of University Communications

Gardner-Webb NewsCenter Archive

While exploring the Broad River, students at Gardner-Webb University might observe what looks like a rock, but it’s really a bivalved freshwater mussel or mollusk, points out Dr. David Campbell, associate professor of paleontology and chair of the Department of Natural Sciences. Clams and oysters are examples of bivalved mollusks, and he has studied various species of them since he was a senior in high school (35 years). His son, Timothy, a first-year Gardner-Webb student, is carrying on the tradition, and recently father and son presented their research at the international meeting on bivalves at Cambridge University in England.

Antimicrobial Resistance And Rational Prescription Practices: Knowledge, Perceptions And Confidence Of Health Profession Interns In Uganda, Shamim Nabidda, Rogers Ssennyonjo, Joseph Atwaru, Andrew Marvin Kanyike, Shiellah Baryayaka, Kennedy Pangholi, Jonans Tusiimire

School of Nursing & Midwifery, East Africa

Background

Antimicrobial resistance (AMR) is significantly driven by misuse and overuse of antibiotics. Graduate health profession interns often prescribe antimicrobials under minimum supervision.

Objectives

This study explored the knowledge, perceptions and confidence of health profession interns in Uganda regarding AMR and rational prescription practices.

Methods

This was a cross-sectional survey employing quantitative techniques carried out between October and November 2022 at six tertiary hospitals in Uganda. Health profession interns including doctors, nurses, midwives and pharmacists were recruited as study participants. Data were collected using online Kobo toolbox software. Data analysis was performed using STATA (StataCorp) version 16. Bivariate analysis and …

Multifunctional Porous Materials For Water Purification And Remediation, Shengqian Ma, Qi Sun, Briana Aguila

USF Patents

A variety of compositions and materials are provided for water purification and remediation. The compositions including multiple functionalities for treating a variety of pollutants or contaminants. The compositions can include a porous organic polymer with one or more of a variety of functional groups for binding the contaminants and with a hierarchical pore size distribution over a range of pore sizes to facilitate enhanced removal of the contaminants. Functional groups can include one, two, or more different functional groups such as amines, halides, ammoniums, pyridiuiums, thiols, imidazoliums, salts thereof, or others. The range of pore sizes can be about 1 …

Chapter Ix — Derailed Modernization: The Ethnonationalist Phase, Messay Kebede

Ethiopian Modernization: Opportunities and Derailments

The last chapter concluded with the generalized expectation that the fall of the Derg would set in motion some form of democratization dismantling the wide-ranging restrictions of the existing socialist system, even if there was uncertainty about the real political program of the victorious Tigrean insurgents. Despite promises of democratization, it did not take long for people to realize that Ethiopia was heading for yet another version of hegemonic rule, this one replacing the class ideology of the previous regime with ethnonationalism. As though a curse were on it, Ethiopia’s modernization will once more stumble over an ideology and a …

Deleterious Mutations Predicted In The Sorghum (Sorghum Bicolor) Maturity (Ma) And Dwarf (Dw) Genes From Whole‑Genome Resequencing, Nathan P. Grant, John J. Toy, Deanna L. Funnell, Scott E. Sattler

Department of Agronomy and Horticulture: Faculty Publications

In sorghum [Sorghum bicolor (L.) Moench] the Maturity (Ma1, Ma2, Ma3, Ma4, Ma5, Ma6) and Dwarf (Dw1, Dw2, Dw3, Dw4) loci, encode genes controlling flowering time and plant height, respectively, which are critical for designing sorghum ideotypes for a maturity timeframe and a harvest method. Publicly available whole-genome resequencing data from 860 sorghum accessions was analyzed in silico to identify genomic variants at 8 of these loci (Ma1, Ma2, Ma3, Ma5, Ma6, Dw1, Dw2, Dw3) to identify novel loss …

Effect Of Preoperative Programmed Death-1 Or Programmed Death Ligand-1 Immune Check Point Inhibition On Complications After Surgery For Primary Head And Neck Cancer, Ramez Philips, Angela Alnemri, Dev Amin, Jena Patel, Michael C. Topf, Jennifer M. Johnson, Voichita Bar-Ad, Rita Axelrod, Athanassios Argiris, Christopher Fundakowski, Adam J. Luginbuhl, David M. Cognetti, Joseph M. Curry

Jefferson Hospital Staff Papers and Presentations

BACKGROUND: There is sparse literature on the effect of preoperative immunotherapy on complications after surgery for primary head and neck squamous cell carcinoma (HNSCC). The objectives are to compare complication rates in patients receiving surgery with and without neoadjuvant immune checkpoint inhibitors (nICI) for primary HNSCC and to evaluate factors associated with increased odds of surgical complications.

METHODS: A retrospective review of patients who underwent ablation and free flap reconstruction or transoral robotic surgery (TORS) for primary HNSCC between 2017-2021 was conducted. Complications were compared between patients who underwent surgery with or without nICI before and after propensity score matching. …

Multi-Factor Optimization Of Bio-Methanol Production Through Gasification Process Via Statistical Methodology Coupled With Genetic Algorithm, Amin Hedayati Moghaddam, Morteza Esfandyari, Dariush Jafari, Hossein Sakhaeinia

Department of Civil and Environmental Engineering: Faculty Publications

This work innovatively explores the bio-methanol production process, conducts comprehensive analyses, develops statistical models, and optimizes operational conditions, contributing valuable insights to the field of sustainable energy production from biomass. Accordingly, bio-methanol production from biomass through gasification route was investigated and simulated using Aspen Plus software. The effects of operational parameters on energy duty of gasification reactor and the methanol production rate in syngas to methanol reactor were investigated. The parameters affecting the process performance including temperature, pressure, and steam/feed ratio were examined using the response surface methodology (RSM) by central composite design (CCD) technique. Analysis of variance (ANOVA) was …

Multi-Factor Optimization Of Bio-Methanol Production Through Gasification Process Via Statistical Methodology Coupled With Genetic Algorithm, Amin Hedayati Moghaddam, Morteza Esfandyari, Dariush Jafari, Hossein Sakhaeinia

Department of Civil and Environmental Engineering: Faculty Publications

This work innovatively explores the bio-methanol production process, conducts comprehensive analyses, develops statistical models, and optimizes operational conditions, contributing valuable insights to the field of sustainable energy production from biomass. Accordingly, bio-methanol production from biomass through gasification route was investigated and simulated using Aspen Plus software. The effects of operational parameters on energy duty of gasification reactor and the methanol production rate in syngas to methanol reactor were investigated. The parameters affecting the process performance including temperature, pressure, and steam/feed ratio were examined using the response surface methodology (RSM) by central composite design (CCD) technique. Analysis of variance (ANOVA) was …

Lung Resident Memory B Cells Maintain Allergic Ige Responses In The Respiratory Tract, Alexander James Nelson

Dissertations

Immunoglobulin E (IgE) is the primary cause of allergic asthma. Allergen-specific IgE can be detected in the airway of allergic asthma patients even in the absence of circulating IgE, suggesting that IgE can be synthesized locally in the respiratory tract. However, the source of IgE-producing B cells, as well as how IgE responses arise and persist at mucosal sites are not fully understood. To address these questions, we modeled allergic asthma in mice by repeated intranasal administration of ragweed pollen and ovalbumin (OVA). We found that allergen exposure induced the production of local IgE in the airway and formation of …

Characterizing The Utility Of A Near Infrared Click Beetle Luciferase For Bli Applications, Giovanni Duca

Master's Theses

Bioluminescent imaging systems (BLI) have become a valuable tool for doing real-time in vivo studies. BLI systems typically allow for the imaging of surface and subsurface level tissues but as depth increases, the resolution decreases while the signal to noise ratio increases. Deep tissue imaging is therefore a major limitation for BLI. To address this limitation there has been a consistent movement in luciferase research to create long wavelength emitting luciferases that still have a high photon emission rate. Longer wavelengths of light are able to penetrate deeper tissues due to having a lower amount of absorbance and scattering from …

Undergraduate And Graduate Students’ Challenges: A Qualitative Study With Ondas Framework Across Multiple Disciplines And Innovative Research Methodologies, Omar Khasro Akram, Daniel José Franco, Apina Lee

The Qualitative Report

The integration levels among research methods, management, research tools, and psychology could guide the development of the ONDAS framework toward the secrets of knowledge. The research grounds on undergraduate and graduate students' challenges, with particular emphasis on the need for writing critical literature reviews and weaknesses in identifying benchmark studies to extract the research gap and main research questions, resulting in most fresh graduate students not graduating on time. Some master’s students write doctoral theses, and vice versa, confusing their identified research approach. The study utilizes desk documents to identify the main problems that most students experienced during their research, …

Alumni Award Winners To Be Honored During Homecoming, Emily J. Schubert

News and Events (Discontinued Series)

No abstract provided.

Spa-Stocsy: An Automated Tool For Identifying Annotated And Non-Annotated Metabolites In High-Throughput Nmr Spectra, Ismael Ai-Ramahi, Juan Botas, Kevin Mackenzie, Genevera I Allen, Damian W Young, Zhandong Liu, Mirjana Maletic-Savatic

Faculty, Staff and Students Publications

MOTIVATION: Nuclear magnetic resonance spectroscopy (NMR) is widely used to analyze metabolites in biological samples, but the analysis requires specific expertise, it is time-consuming, and can be inaccurate. Here, we present a powerful automate tool, SPatial clustering Algorithm-Statistical TOtal Correlation SpectroscopY (SPA-STOCSY), which overcomes challenges faced when analyzing NMR data and identifies metabolites in a sample with high accuracy.

RESULTS: As a data-driven method, SPA-STOCSY estimates all parameters from the input dataset. It first investigates the covariance pattern among datapoints and then calculates the optimal threshold with which to cluster datapoints belonging to the same structural unit, i.e. the metabolite. …

Scribbledom: Using Scribble-Annotated Histology Images To Identify Domains In Spatial Transcriptomics Data, Mohammed Abid Abrar, Md Abul Hassan Samee, M Saifur Rahman

Faculty, Staff and Students Publications

Motivation

Spatial domain identification is a very important problem in the field of spatial transcriptomics. The state-of-the-art solutions to this problem focus on unsupervised methods, as there is lack of data for a supervised learning formulation. The results obtained from these methods highlight significant opportunities for improvement.

Results

In this article, we propose a potential avenue for enhancement through the development of a semi-supervised convolutional neural network based approach. Named “ScribbleDom”, our method leverages human expert’s input as a form of semi-supervision, thereby seamlessly combines the cognitive abilities of human experts with the computational power of machines. ScribbleDom incorporates a …

The Breast Cancer Proteome And Precision Oncology, Matthew V Holt, Xi Li, Meenakshi Anurag, Matthew J Ellis, Gordon B Mills, Bing Zhang, Marilyne Labrie

Faculty, Staff and Students Publications

The goal of precision oncology is to translate the molecular features of cancer into predictive and prognostic tests that can be used to individualize treatment leading to improved outcomes and decreased toxicity. Success for this strategy in breast cancer is exemplified by efficacy of trastuzumab in tumors overexpressing ERBB2 and endocrine therapy for tumors that are estrogen receptor positive. However, other effective treatments, including chemotherapy, immune checkpoint inhibitors, and CDK4/6 inhibitors are not associated with strong predictive biomarkers. Proteomics promises another tier of information that, when added to genomic and transcriptomic features (proteogenomics), may create new opportunities to improve both …

Privacy-Preserving Federated Genome-Wide Association Studies Via Dynamic Sampling, Xiaoqian Jiang, Jaideep Vaidya

Faculty, Staff and Student Publications

MOTIVATION: Genome-wide association studies (GWAS) benefit from the increasing availability of genomic data and cross-institution collaborations. However, sharing data across institutional boundaries jeopardizes medical data confidentiality and patient privacy. While modern cryptographic techniques provide formal secure guarantees, the substantial communication and computational overheads hinder the practical application of large-scale collaborative GWAS.

RESULTS: This work introduces an efficient framework for conducting collaborative GWAS on distributed datasets, maintaining data privacy without compromising the accuracy of the results. We propose a novel two-step strategy aimed at reducing communication and computational overheads, and we employ iterative and sampling techniques to ensure accurate results. We …

Sex Differences In Recognition Of Face Expressions, Albandri Alotaibi, Abeer Aljuhani, Manal Alqahtani, Nadia Alahmari

Journal of Educational and Psychological Studies

Abstract:Emotional facial expressions are a crucial non-verbal communication skill for humans’ interactions. The current study assessed the impact of sex on emotional face recognition. A total of 125 individuals per-formed an online emotional face recognition task. The stimuli were created recutting male and female Saudi volunteers. Results showed that, except of the male participants having faster responses compared to females in general, no main significant differences between the sex group in accuracy nor any significant interaction between participant sex and the sex of the faces. Our findings suggests that the effect of sex on emotional face recognition needs further investigation …

Effectiveness Of Out-Patient Based Acute Heart Failure Care: A Pilot Randomised Controlled Trial, Kyk Wong, D. A. Hughes, M. Debski, N. Latt, O. Assaf, A. Abdelrahman, R. Taylor, V. Allgar, L. Mcneill, S. Howard, Sys Wong, R. Jones, C. J. Cassidy, A. Seed, G. Galasko, A. Clark, D. Wilson, G. K. Davis, A. Montasem, C. C. Lang, P. R. Kalra, R. Campbell, G. Y.H. Lip, J. G.F. Cleland

Peninsula Medical School

Objectives Acute heart failure (AHF) hospitalisation is associated with 10% mortality. Outpatient based management (OPM) of AHF appeared effective in observational studies. We conducted a pilot randomised controlled trial (RCT) comparing OPM with standard inpatient care (IPM). Methods We randomised patients with AHF, considered to need IV diuretic treatment for ≥2 days, to IPM or OPM. We recorded all-cause mortality, and the number of days alive and out-of-hospital (DAOH). Quality of life, mental well-being and Hope scores were assessed. Mean NHS cost savings and 95% central range (CR) were calculated from bootstrap analysis. Follow-up: 60 days. Results Eleven patients were …

Message From The President, Georgia Southern University

Messages from the President

No abstract provided.

A Portable And Low-Cost Incubator System Enabling Real-Time Cell Imaging Based On A Smartphone, Ari̇f Engi̇n Çeti̇n

Turkish Journal of Physics

Incubators serve as essential tools for maintaining optimal temperature, humidity, and atmospheric gas composition for cell cultures. Their applications span across various fields like cell biology, microbiology, and molecular biology. However, in many cell-based studies, observing cellular changes often necessitates moving cells out of the incubator for microscope examination. Unfortunately, exposing cells to an environment that does not support healthy growth can undermine the reliability of test outcomes. In this article, we present a groundbreaking solution: a cost-effective, portable incubator system seamlessly integrated with a smartphone for real-time characterization tests. This innovation offers comparable imaging capabilities and maintains an environment …

Overcoming Challenges In Chemical Glycosylation To Achieve Innovative Vaccine Adjuvants Possessing Enhanced Tlr4 Activity, Alessio Romerio, Ana Rita Franco, Melanie Shadrick, Mohammed Monsoor Shaik, Valentina Artusa, Alice Italia, Federico Lami, Alexei V. Demchenko, Francesco Peri

Chemistry & Biochemistry Faculty Works

Lipopolysaccharide (LPS) mimicry leading to toll-like receptor 4 (TLR4) active compounds has been so far based mainly on reproducing the lipid A portion of LPS. Our work led to a series of structurally simplified synthetic TLR4 agonists in preclinical development as vaccine adjuvants called FPs. FPs bind MD2/TLR4 similarly to lipid A, inserting the lipid chains in the MD2 lipophilic cavity. A strategy to improve FPs’ target affinity is introducing a monosaccharide unit in C6, mimicking the first sugar of the LPS core. We therefore designed a panel of FP derivatives bearing different monosaccharides in C6. We report here the …

Association Between Socioeconomic Factors, Race, And Use Of A Specialty Memory Clinic, Abigail Lewis, Aditi Gupta, Inez Oh, Suzanne E. Schindler, Nupur Ghoshal, Zachary Abrams, Randi Foraker, Barbara Joy Snider, John C. Morris, Joyce Balls-Berry, Mahendra Gupta, Philip R. O. Payne, Albert M. Lai

2020-Current year OA Pubs

BACKGROUND AND OBJECTIVES: The capacity of specialty memory clinics in the United States is very limited. If lower socioeconomic status or minoritized racial group is associated with reduced use of memory clinics, this could exacerbate health care disparities, especially if more effective treatments of Alzheimer disease become available. We aimed to understand how use of a memory clinic is associated with neighborhood-level measures of socioeconomic factors and the intersectionality of race.

METHODS: We conducted an observational cross-sectional study using electronic health record data to compare the neighborhood advantage of patients seen at the Washington University Memory Diagnostic Center with the …

An Update On Strategies To Deliver Protein And Peptide Drugs To The Eye, Sai H S Boddu, Devarshi Acharya, Vivek Hala, Harshil Jani, Sonal Pande, Moyad Shahwan, Ketan M Ranch

Faculty, Staff and Student Publications

In the past few decades, advancements in protein engineering, biotechnology, and structural biochemistry have resulted in the discovery of various techniques that enhanced the production yield of proteins, targetability, circulating half-life, product purity, and functionality of proteins and peptides. As a result, the utilization of proteins and peptides has increased in the treatment of many conditions, including ocular diseases. Ocular delivery of large molecules poses several challenges due to their high molecular weight, hydrophilicity, unstable nature, and poor permeation through cellular and enzymatic barriers. The use of novel strategies for delivering protein and peptides such as glycoengineering, PEGylation, Fc-fusion, chitosan …

Comparative Genomic Landscape Of Urothelial Carcinoma Of The Bladder Among Patients Of East And South Asian Genomic Ancestry, Andrea Necchi, Natalie Danziger, Joseph M Jacob, Gennady Bratslavsky, Jeffrey S Ross

Faculty, Staff and Student Publications

BACKGROUND: Despite the low rate of urothelial carcinoma of the bladder (UCB) in patients of South Asian (SAS) and East Asian (EAS) descent, they make up a significant portion of the cases worldwide. Nevertheless, these patients are largely under-represented in clinical trials. We queried whether UCB arising in patients with SAS and EAS ancestry would have unique genomic features compared to the global cohort.

METHODS: Formalin-fixed, paraffin-embedded tissue was obtained for 8728 patients with advanced UCB. DNA was extracted and comprehensive genomic profiling was performed. Ancestry was classified using a proprietary calculation algorithm. Genomic alterations (GAs) were determined using a …

Quality Of Life In Male Breast Cancer: Prospective Study Of The International Male Breast Cancer Program (Eortc10085/Tbcrc029/Big2-07/Nabcg), Carolien P Schröder, Elise Van Leeuwen-Stok, Fatima Cardoso, Barbro Linderholm, Coralie Poncet, Vesna Bjelic-Radisic, Miguel H Abreu, Ivana Bozovic-Spasojevic, Irma Den Hoed, Aafke H Honkoop, Maartje Los, Jose P Leone, Nicola S Russell, Tineke J Smilde, Annette W G Van Der Velden, Catherine Van Poznak, Marije M Vleugel, Rachel L Yung, Corneel Coens, Sharon H Giordano, Kathryn J Ruddy

Faculty, Staff and Student Publications

INTRODUCTION: Prospective data about quality of life (QoL) in men with breast cancer (BC) are lacking. A prospective registry (EORTC10085) of men with all BC stages, including a QoL correlative study, was performed as part of the International Male Breast Cancer Program.

METHODS: Questionnaires at BC diagnosis included the EORTC QLQ-C30 and BR23 (BC specific module), adapted for men. High functioning and global health/QoL scores indicate high functioning levels/high QoL; high symptom-focused measures scores indicate high symptoms/problems levels. EORTC reference data for healthy men and women with BC were used for comparisons.

RESULTS: Of 422 men consenting to participate, 363 …

Report Of The Assay Guidance Workshop On 3-Dimensional Tissue Models For Antiviral Drug Development, Anthony Atala, Jeffrey T Borenstein, Kyle R Brimacombe, Sara Cherry, Hans Clevers, Mindy I Davis, Simon G P Funnell, Lee Gehrke, Linda G Griffith, Abigail C Grossman, Thomas Hartung, Donald E Ingber, Nicole C Kleinstreuer, Calvin J Kuo, Emily M Lee, Christine L Mummery, Thames E Pickett, Sasirekha Ramani, Edwin A Rosado-Olivieri, Evi B Struble, Zhengpeng Wan, Mark S Williams, Matthew D Hall, Marc Ferrer, Sarine Markossian

Faculty, Staff and Students Publications

The National Center for Advancing Translational Sciences (NCATS) Assay Guidance Manual (AGM) Workshop on 3D Tissue Models for Antiviral Drug Development, held virtually on 7-8 June 2022, provided comprehensive coverage of critical concepts intended to help scientists establish robust, reproducible, and scalable 3D tissue models to study viruses with pandemic potential. This workshop was organized by NCATS, the National Institute of Allergy and Infectious Diseases, and the Bill and Melinda Gates Foundation. During the workshop, scientific experts from academia, industry, and government provided an overview of 3D tissue models' utility and limitations, use of existing 3D tissue models for antiviral …

Effects Of An Ionic Bracelet On Physical, Cognitive, And Integrative Tasks, Eileen Bringman, Chelsea Kimura, Philip Schot

International Journal of Undergraduate Research and Creative Activities

Abstract: One approach in complementary/alternative medicine posits that manipulations of undocumented body energy patterns (biofields) can improve health and function. Various clinician-delivered interventions focus on biofields, but devices that purportedly correct these are also marketed and claim immediate benefits in a variety of domains. OBJECTIVE: To determine acute effects of ionic bracelet use on physical, cognitive and integrative sports-related tasks. METHODS: 52 healthy young adults participated (9 men and 43 women; 20.2±3.4 years of age; 65.4±11.3 kg; 165±6.9 cm). None reported prior or current use of the product. Each completed 2 series of 6 tasks wearing the ionic and an …

An Alternative Strategy For Fabrication Of Robust And Flexible Digital Microfluidic Devices, Nathaniel Thorne, Melissa Lamberto, Audrey Mazza, Sergio Freire

International Journal of Undergraduate Research and Creative Activities

We present a new strategy for the fabrication of digital microfluidic (DMF) devices by research groups without access to well-equipped facilities. Compared to previously developed methods, it increases considerably device yield, and yet simplifies fabrication and enables flexible operation.To this end, we use large (260 and 400 μm) interelectrode gaps to optimize substrate fabrication, breaking the established constraint that gap dimensions must be small (usually < 150 μm) for digital microfluidics. In fact, we show that interelectrode gaps are not limiting features for DMF performance, and may be quite large (> 1 mm). Smooth droplet actuation is ensured by films of perfluoroalkoxy (PFA), which do not require additional coatings; films can be instantly replaced, without the necessity of annealing. Finally, our tests indicate that DMF devices …

The Effects Of Herbal Products In Cartilage Healing And Reducing The Progression Of Osteoarthritis, Mariya Baig, Mir Saleem

Mako: NSU Undergraduate Student Journal

Treatment for osteoarthritis (OA) includes symptom management with nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, and acetaminophen. However, these drugs pose health risks for long-term use, such as contraindications and gastrointestinal/cardiovascular issues. This systematic review of the literature was conducted to evaluate the impact of the herbal products, turmeric and ginger, in cartilage healing and reducing the progression of OA. It was found that turmeric and ginger can aid in symptom management for OA and promote cartilage regeneration, with turmeric extract yielding greater evidence-based results. Turmeric reduces the amount of pain and stiffness experienced from OA and can restore cartilage by subduing …

Can The Use Of Art And Active Learning Improve Retention And Observational Skill Confidence Among Audiology Graduate Students, Aurora Weaver, Ashlyn Wheat, Travis Riffle, Chelsea Powell, Lindsey Leonard, Ryleigh Prickett, Anna Hill, Larry Molt

Teaching and Learning in Communication Sciences & Disorders

Human anatomy and physiology is considered one of the most difficult courses a student can take in a pre-health professional major in the US (Slominski, et. al., 2017). Research has revealed benefits of the use of art and anatomy within medical education, including improved clinical observational skills, greater understanding of disease and patient perspectives, and greater ability to empathize (Bell & Evans, 2014). Bell and Evans (2014) argue that observational skills are often overlooked in medical education. Use of art assignments in a graduate anatomy and physiology course will be discussed with reference to design and learning outcomes. The purpose …