Digital Commons Network^™

What's Not Natural Phenomena? Let's Consider A Three-Step Innovative Concept Test For Composition Of Matter Claims, Sydney Hancock

IP Theory

Biotechnology innovation is rapidly growing, especially in the realm of biotech. This growth leads to questions about patent subject matter eligibility of natural phenomena. For example, currently the human genome and microbiome are being extensively studied, bacteriophages are being edited, animals are being cloned, and CRISPR is widespread. Additionally, composition of matter patent claims give the most protection to patent holders. Therefore, knowing when a natural phenomenon veers into human innovation is important for courts, lawyers, and innovators in the era of biotechnology and genetic engineering.

Part I discusses the history of Supreme Court cases on natural phenomena subject matter …

Dobbs' Sex Equality Troubles, Marc Spindelman

William & Mary Bill of Rights Journal

This article takes up what Dobbs v. Jackson Women's Health Org. may mean for sex equality rights beyond the abortion setting. It details how Dobbs lays the foundation for rolling back and even eliminating Fourteenth Amendment sex equality protections. The work scales these possibilities against a different dimension of the ruling that’s yet to receive the attention that it merits. An important footnote in Dobbs, Footnote 22, sketches a new history-and-tradition-based approach to unenumerated rights under the Fourteenth Amendment’s Privileges or Immunities Clause. The jurisprudence that this Footnote capacitates could transform the constitutional landscape via new economic and social …

Association Of Prolactin With All-Cause And Cardiovascular Mortality Among Patients With Type 2 Diabetes: A Real-World Study, Yun Shen, Qing Yang, Tingting Hu, Yaxin Wang, Lei Chen, Fei Gao, Wei Zhu, Gang Hu, Jian Zhou, Chunfang Wang, Yuqian Bao

Population and Public Health Science Faculty Publications

Aims The association between prolactin and mortality has been less studied, and findings were inconsistent among different populations. We aimed to investigate the association between serum prolactin (PRL) and mortality among patients with type 2 diabetes. Methods We performed a retrospective cohort study of 10 907 patients with at least 2 prolactin measurements within 2 years since and results their first inpatient diagnosis of type 2 diabetes. Baseline and mean values of serum PRL were used as exposures. A multivariable-adjusted Cox proportional hazards model was used to estimate the association between PRL and mortality. During a mean follow-up of 5.34 …

Rare Variants Found In Multiplex Families With Orofacial Clefts: Does Expanding The Phenotype Make A Difference?, Kimberly K Diaz Perez, Sydney Chung, S Taylor Head, Michael P Epstein, Jacqueline T Hecht, George L Wehby, Seth M Weinberg, Jeffrey C Murray, Mary L Marazita, Elizabeth J Leslie

Faculty, Staff and Student Publications

Exome sequencing (ES) is now a relatively straightforward process to identify causal variants in Mendelian disorders. However, the same is not true for ES in families where the inheritance patterns are less clear, and a complex etiology is suspected. Orofacial clefts (OFCs) are highly heritable birth defects with both Mendelian and complex etiologies. The phenotypic spectrum of OFCs may include overt clefts and several subclinical phenotypes, such as discontinuities in the orbicularis oris muscle (OOM) in the upper lip, velopharyngeal insufficiency (VPI), microform clefts or bifid uvulas. We hypothesize that expanding the OFC phenotype to include these phenotypes can clarify …

Specialized Astrocytes Mediate Glutamatergic Gliotransmission In The Cns, Roberta De Ceglia, Ada Ledonne, David Gregory Litvin, Barbara Lykke Lind, Giovanni Carriero, Emanuele Claudio Latagliata, Erika Bindocci, Maria Amalia Di Castro, Iaroslav Savtchouk, Ilaria Vitali, Anurag Ranjak, Mauro Congiu, Tara Canonica, William Wisden, Kenneth Harris, Manuel Mameli, Nicola Mercuri, Ludovic Telley, Andrea Volterra

Biomedical Sciences Faculty Research and Publications

Multimodal astrocyte–neuron communications govern brain circuitry assembly and function. For example, through rapid glutamate release, astrocytes can control excitability, plasticity and synchronous activity of synaptic networks, while also contributing to their dysregulation in neuropsychiatric conditions. For astrocytes to communicate through fast focal glutamate release, they should possess an apparatus for Ca2+-dependent exocytosis similar to neurons. However, the existence of this mechanism has been questioned owing to inconsistent data and a lack of direct supporting evidence. Here we revisited the astrocyte glutamate exocytosis hypothesis by considering the emerging molecular heterogeneity of astrocytes and using molecular, bioinformatic and imaging approaches, together with …

Suny Cortland Handbook 2023, State University Of New York College At Cortland

SUNY Cortland Handbook

No abstract provided.

Les Pollinator Habitat, Chloe Herbert, Dillon Richert, Melissa Landis

Environmental Engagement in the Community (ENVR 319): Student Projects

Environmental Engagement in the Community projects, fall 2023

A poster titled LES Pollinator Habitat for client Lincoln Electric System (C. Herbert and D. Richert with M. Landis).

Avian Scavenging In The Forensic Context, Austin Millwood

Senior Theses

Many cultures have recognized the importance of birds in scavenging. However, within forensic literature and research, avian scavenging is an understudied phenomenon. Despite this, researchers have shown that scavenging by birds is unique from other types of scavenging in that birds can rapidly cause complete skeletonization, leave relatively little bone damage, and can spread remains and artifacts over a large area. Here birds known to scavenge are explained in a biological context and then their effects on remains are analyzed. Birds are capable of completely scavenging human remains in as little as 5 hours, depending on many understudied factors. Avian …

Studies Of Damage Tolerance In Automated Fiber Placement Based Heterogeneous Meso-Architectured Carbon/ Epoxy Composite Laminates., Karan Kodagali

Theses and Dissertations

Traditional unidirectional (UD) carbon fiber-reinforced polymer matrix composites manufactured via automated fiber placement (AFP) are widely used in aerospace structures. While heterogeneous at the micro-scale, these materials are homogeneous at the meso-scale (ply-scale). The major limitation is its limited toughness, poor damage tolerance/impact resistance capability and the inability to sufficiently redistribute stresses, resulting in strength-toughness tradeoffs, making them susceptible to impact damage. From previous studies, there is an understanding that fiber architecture has a first order effect on the damage tolerance. Introducing new discontinuous/heterogeneous meso-scale architectures, through an optimal merger of material and structure, can result in unprecedented property improvements …

Quantification Of The Internalization Of A Commercially Available Silver Nanoparticle To The Bacterium Escherichia Coli, Samantha Mcneal Case

Theses and Dissertations

Nanoparticles (NPs), materials with dimensions ranging from 1 to 100 nanometers, are widely used in various consumer products, with silver nanoparticles (AgNPs) being the most prominent. Exposure to AgNPs occurs through multiple sources, including food packaging, supplements, and disinfectants, owing to their antimicrobial properties. Prior research has identified adverse health effects, such as cytotoxicity, toxicity, and Ag bioaccumulation resulting from AgNP exposure to bacteria in biological systems and the environment. However, most studies employ pristine, highly concentrated NPs, which may not accurately represent realistic exposure scenarios at environmentally relevant concentrations. This project investigates the fate and internalization of AgNPs, found …

Water Quality Monitoring And Mapping Using Rapidly Deployable Sensor Nodes, Mohamed Abdelwahab

Theses and Dissertations

Efficient and continuous monitoring of water quality parameters plays a pivotal role in responding to pollution incidents and ensuring the safety of both human consumption and ecological resources. This research introduces an affordable and dependable in-situ water quality sensor package designed for seamless continuous monitoring, providing essential data to facilitate informed decision-making in water resource management. The sensor package enables comprehensive on-site assessment of key water characteristics, including pH, temperature, turbidity (measured in NTU), and total dissolved solids (TDS, measured in ppm). Spatial interpolation techniques, specifically Kriging, are employed to extrapolate variable values at unobserved locations based on nearby measurements. …

Review Essay: Enjoyment And Ideology Surplus-Enjoyment: A Guide For The Non-Perplexed Slavoj Žižek. London: Bloomsbury Academic. 2022. Pp. 400., Edward Sankowski, Betty J. Harris

International Dialogue

Slavoj Žižek’s Surplus-Enjoyment-A Guide for the Non-Perplexed is a difficult book. Reading it requires a different approach from what is usual with what seems to us more standardized philosophical or social scientific prose. Our approach initially at least no doubt assumes as our starting point a deploying of our shared norms, shaped by our backgrounds as U.S. based scholars aiming to advance dialogue with Žižek and some of the wide variety of authors with whom Žižek himself engages.

Politics By Other Means: The Jurisprudence Of “Common Good Constitutionalism”, Brian Leiter

University of Chicago Law Review

Professor Adrian Vermeule proposes an alternative to what he sees as the two dominant schools of constitutional interpretation in the United States: originalism and what he usually calls “progressivism”¹ (by which he means what others call “living constitutionalism”² ). Against these approaches, he advocates for what Freudians might call a “return of the repressed”³: a recognition of the extent to which the “classical” natural law tradition’s concern with the “common good” has continued to animate our public law—explicitly for much of our history, he says, and implicitly more recently.

On Vermeule’s proposed alternative, courts (and other …

Ischemia Modified Albumin In Maternal Serum And Cord Blood In Relation To Preeclampsia Severity And Neonatal Outcome, Sarah Sulaiman, Maha Jasim Al-Bayati

Iraqi Postgraduate Medical Journal

BACKGROUND:Preeclampsia is associated with ischemia and increased oxidative stress in the placenta. Ischemia-modified albumin has been widely accepted as a serological biomarker in preeclampsia.OBJECTIVE:To evaluate the relationship between maternal serum and cord blood ischemia modified albumin levels with preeclampsia severity and neonatal outcome.PATIENTS AND METHODS:This study includes 90 pregnant women who were divided into three groups: Group 1 includes 30 pregnant women with severe preeclampsia. Group 2 includes 30 pregnant women with mild preeclampsia. Group 3 includes 30 normotensive pregnant women with uncomplicated pregnancy considered as control group. The three groups were matched for age and gestational age. Maternal blood …

Dynamic Contrast Enhanced Magnetic Resonance Imaging In Pathological Nipple Discharge, Balsam Balasim, Sahar Ahmed

Iraqi Postgraduate Medical Journal

BACKGROUND: Generally, nipple discharge represents a benign etiology. In the case where the discharge is unilateral, uniductal, spontaneous, persistent, serous or bloody, and in the case where it occurs in conjunction with a mass, the risk of malignancy is increased. Ductal ectasia and papilloma are the most common causes of pathological nipple discharges. Malignancy is a possibility, most often ductal carcinoma in situ.OBJECTIVE: To determine the value regarding dynamic contrast improved magnetic resonance imaging (MRI) in diagnosing suspicious nipple discharge.METHOD AND PATIENTS:Dynamic contrast MRI was used to assess 35 patients who have pathological nipple discharges.                    The features of MRI have …

Career Influences Of Environmental Education Field Experiences, Lacey Day

School of Education and Leadership Student Capstone Theses and Dissertations

As an environmental educator who got her start exploring the various flora and fauna around me, it has always interested me to know whether the same experiences that got me to where I am today have also influenced others to pursue similar careers. This study, because of that initial interest, set out to determine How do environmental education field experiences influence college major and/or career choice in high school students? Through a 21 question, cross-sectional survey, high school students in Allegany County Public Schools were asked a series of questions pertaining to their environmental educational field experiences, their values and …

Firearm Contagion: A New Look At History, Rachel Martin, Michael R. Ulrich

Fordham Urban Law Journal

No abstract provided.

The Effects Of Landscape And Yard Features On Mammal Diversity In Residential Yards Within Northwest Arkansas, Usa, Emily P. Johansson, Brett A. Degregorio

Biological Sciences Faculty Publications and Presentations

The human footprint is rapidly expanding, and wildlife habitat is continuously being converted to human residential properties. Surviving wildlife that reside in developing areas are displaced to nearby undeveloped areas. However, some animals can co-exist with humans and acquire the necessary resources (food, water, shelter) within the human environment. This ability to coexist may be particularly true when development is low intensity, as in residential suburban yards. Yards are individually managed “greenspaces” that can provide a range of food (e.g., bird feeders, compost, gardens), water (bird baths and garden ponds), and shelter (e.g., brush-piles, outbuildings) resources and are surrounded by …

The Himalayan Uplift And Evolution Of Aquatic Biodiversity Across Asia: Snowtrout (Cyprininae: Schizothorax) As A Test Case, Binod Regmi, Marlis R. Douglas, Karma Wangchuk, Zachery D. Zbinden, David R. Edds, Singye Tshering, Michael E. Douglas

Biological Sciences Faculty Publications and Presentations

Global biodiversity hotspots are often remote, tectonically active areas undergoing climatic fluctuations, such as the Himalaya Mountains and neighboring Qinghai-Tibetan Plateau (QTP). They provide biogeographic templates upon which endemic biodiversity can be mapped to infer diversification scenarios. Yet, this process can be somewhat opaque for the Himalaya, given substantial data gaps separating eastern and western regions. To help clarify, we evaluated phylogeographic and phylogenetic hypotheses for a widespread fish (Snowtrout: Cyprininae; Schizothorax) by sequencing 1,140 base pair of mtDNA cytochrome-b (cytb) from Central Himalaya samples (Nepal: N = 53; Bhutan: N = 19), augmented with 68 GenBank …

Predicting Stringent Quantiferon-Tb Gold Plus Conversions In Contacts Of Tuberculosis Patients, Sheng-Wei Pan, Donald G. Catanzaro, Marva Seifert, Rehan Syed, Naomi Hillery, Mei-Lin Ho, Valeriu Crudu, Elena Tudor, Nelly Ciobanu, Alexandru Codreanu, Antonino Catanzaro, Timonthy C. Rodwell

Biological Sciences Faculty Publications and Presentations

Objectives

Methods

Results

Vaccine Development, The China Dilemma, And International Regulatory Challenges, Peter K. Yu

Faculty Scholarship

This article examines the role played by China in the development of international regulatory standards at the intersection of intellectual prop- erty, international trade, and public health. It begins by briefly discussing the role China has played in the global health arena during the COVID-19 pandemic. The article then highlights the difficulty in determining how best to engage with the country in the development of new international regula- tory standards. It shows that the preferred method of engagement will likely depend on one’s perspective on China’s potential contributions and hin- drances: a perspective that focuses on global competition—in the economic, …

Revised Draft Final Quarterly Operations And Maintenance Report Butte Treatment Lagoon System – First Quarter 2022, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Revised Draft Final Quarterly Operations And Maintenance Report Butte Treatment Lagoon System – Second Quarter 2022, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Design, Fabrication, And Evaluation Of 3-D-Printed Cystotomy Spoons As A Retrieval Method In Dogs, Davina C. D'Angelo, Sam E. Stephens, Morten O. Jensen, Lauren R. Thomas

Animal Science Faculty Publications and Presentations

OBJECTIVE

Current cystotomy methods often implement the use of off-label devices, resulting in urocystolith extraction difficulty and potentially leading to postoperative complications and discomfort for the patient. The objective of this study was to create 3 novel 3-D printed cystotomy spoons that offer a dedicated solution for removing urocystoliths from a patient's urinary bladder.

ANIMALS

Clinical use of the 3 novel 3-D printed cystotomy spoons were ultimately evaluated in 4 dogs and 1 cat that presented for urocystotlith removal at 3 different veterinary hospitals in northwest Arkansas.

METHODS

The novel cystotomy spoons were designed using SolidWorks, 3-D printed with a …

College Of Natural Sciences Newsletter, September - October 2023, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

Page 1 Dean's Message
Page 2 New Faculty an Staff for the Fall 2023 Semester
Page 3 Awards
Page 4 Student Ambassadors in CNS
Page 5 Meet our Jacks
Page 6-8 Events
Page 9-11 Media Coverage of CNS
Page 12-13 Spring 2023 Dean's List
Page 14 Open PRAIRIE Data

Farnesol Brain Transcriptomics In Cns Inflammatory Demyelination, William J. Doyle, Dana Walters, Xutong Shi, Kristina Hoffman, Krisztian Magori, Jean-Baptiste Roullet, Javier Ochoa-Repáraz

Biology Faculty Publications and Presentations

Background: Farnesol (FOL) prevents the onset of experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS).

Objective: We examined the transcriptomic profile of the brains of EAE mice treated with daily oral FOL using next-generation sequencing (RNA-seq).

Methods: Transcriptomics from whole brains of treated and untreated EAE mice at the peak of EAE was performed.

Results: EAE-induced mice, compared to naïve, healthy mice, overall showed increased expression in pathways for immune response, as well as an increased cytokine signaling pathway, with downregulation of cellular stress proteins. FOL downregulates pro-inflammatory pathways and attenuates the immune response in EAE. FOL …

Urban Disaster Wrought By Man: The Battle For Manila, 1945, Russell W. Glenn

Journal of Strategic Security

Urban warfare tends to be intimate. If soldiers do not see the faces of those they kill—and they frequently will—those men and women will hear the screams or muffled groans of the wounded. US forces waging the battle to recapture Manila in 1945 experienced these horrors. Yet it was the noncombatants who suffered far more; 100,000—approximately one of every ten Manileños at the time—died during the fighting. Thousands more suffered wounds, disease, or struggled with hunger and malnutrition. Recent fighting in Syria, Ukraine, Khartoum, and elsewhere tells us too little has changed three-quarters of a century later.

Though urban warfare …

Emeriti News Fall 2023, Emeriti Council

Emeriti News

• Message from the Chair
• Bio-Sketch of Dawn L. Anderson
• Bio-Sketch of Darryl A. Salisbury
• Bio-Sketch of Barbara U. Hemphill
• Medallion Scholars
• Reminders from the Chair
• Administrative Updates
• News from WMU Emeriti
• In Memoriam

[Dataset] Comparison Of Intermittent Fasting And Voluntary Wheel Running On Physical And Cognitive Abilities In High-Fat Diet-Induced Obese Rats, Chaya Gopalan, Paige Niepoetter, Carolyn Butts-Wilmsmeyer, Sai Medavaka, Avery Ogle, Sheyenne Daughrity, Elizabeth Hackmann, Saruveish Mogan, Oskar Lenz

Applied Health Faculty Research, Scholarship, and Creative Activity

Regular physical activity is a proven routine for weight management in addressing obesity. Another method that has gained attention for its health benefits is intermittent fasting (IF). Physical and cognitive abilities while on these routines are poorly understood in the obese population. Sixty-five male Sprague Dawley rats at 7 weeks of age were subjected to diet-induced obesity by feeding a high-fat diet (HFD) or a standard diet (SD) for 8 weeks, after which behavioral testing was performed to detect any changes in physical and cognitive abilities. Rats from the HFD-fed (now considered obese) and SD-fed groups were then subjected to …

Rapid Approach For Assessing An Unregulated Fishery Using A Series Of Data-Limited Tools, Carissa L. Gervasi, Mandy Karnauskas, Adyan Rios, Rolando O. Santos, W. Ryan James, Ryan J. Rezek, Jennifer S. Rehage

Marine Science

Objective: Fisheries provide countless benefits to human populations but face many threats ranging from climate change to overfishing. Despite these threats and an increase in fishing pressure globally, most stocks remain unassessed and data limited. An abundance of data-limited assessment methods exists, but each has different data requirements, caveats, and limitations. Furthermore, developing informative model priors can be difficult when little is known about the stock, and uncertain model parameters could create misleading results about stock status. Our research illustrates an approach for rapidly creating robust initial assessments of unregulated and data-limited fisheries without the need for additional data collection. …