Digital Commons Network^™

Cucurbitacin D Ameliorates Benzo[A]Pyrene Induced Liver Injury Via Activation Of Nrf2 Antioxidant Pathway, Anyssa Rodriguez, Mohammed Sikander, Shabnam Malik, Fathi T. Halaweish, Meena Jaggi, Subhash C. Chauhan

Research Symposium

Background: Co-morbidity variables, such as smoking, are strongly linked to the development and progression of liver cancer. Further, benzo[a]pyrene, a major component of tobacco smoke, is highly carcinogenic and triggers liver damage. Cucurbitacin, a kind of triterpene, has a wide range of biological properties, including antioxidant, anti-inflammatory, and anti-cancer effects. However, the precise mechanism of its hepatoprotective effects is obscure.

Objective: The aim of this study is to investigate the cytoprotective effects of novel analog of cucurbitacin, cucurbitacin D, against benzo[a]pyrene-induced liver injury in HepG2 cells. Method: The cytoprotective efficacy of cucurbitacin D against benzo[a]pyrene-induced liver damage was …

Correlation Between Ct-Values And Symptoms Of Covid-19 Patients, Luis E. Fernández-Garza, A. Huitrón-Carrizales, Hugo A. Barrera-Saldaña, Raúl Rodríguez-Palacios

Research Symposium

Background: Currently available RT-PCR methods for the diagnosis of COVID-19 can give an estimate of the viral load. The cycle threshold value (Ct-value) of the PCR correlates inversely with the viral load; low Ct-values indicate high viral loads and vice versa. Higher viral loads have been seen to correlate with disease severity and infectivity. Therefore, we studied the correlation of the Ct-value of RT-PCR and the most common symptoms of COVID-19 individually.

Methods: A prospective and descriptive study was carried out with the subjects that attended our laboratory for a COVID-19 test from September 14, 2020, to January 30, 2021. …

Comparison Of Five Commercial Kits For Sars Cov 2 Rt-Pcr Diagnosis., Carolina Rivera, Hugo A. Barrera-Saldaña, Marisol Ramirez

Research Symposium

Background: SARS-CoV-2 was identified as the causal agent of the COVID-19 pandemic. Its rapid spread and huge health and economic impact prompted the development of diagnostic tests to opportunely identify affected individuals as a prerequisite to quarantine them and avoid further spreading the infection.

Methods: The following commercial RT-PCR kits, approved by our National Institute of Diagnostics and Epidemiological Reference of InDRE (from the Spanish name) were tested: Vircell (Granda, Spain), Light Mix Roche (Berlin, Germany), Logix Smart (Utah, USA), 1 Copy (Korea Republic), and RIDA GENE (Darmstadt, Germany). RNA was isolated either manually or automatically (QIAmp Viral RNA and …

Biobanking In Ne Mexico For Biomedical Research And Clinical Needs, Raúl Rodríguez-Palacios, Nathalia L. Walle-Gloria, Hugo A. Barrera-Saldaña

Research Symposium

Background: The advancement of biomedicine demands tools that translate its achievements into services to both the scientific community and the pharma/biotech industry. Biobanks are powerful tools that collect, process, store, manage, and distribute biospecimens and their associated clinical/demographic data to users carrying out studies aimed at causing a real public health impact.

For our laboratory to offer pharma/biotech companies support for their projects with the highest quality possible biospecimens we adopted the Best Biobanking Practices from ISBER (https://www.isber.org/).

Methods: As a result of the pandemics, great effort has been dedicated to help the health ecosystem through a diagnostic service for …

Automated Versus Manual Rna Isolation For The Laboratory Diagnosis Of Sars-Cov-2., Raúl Rodríguez-Palacios, Nathalia L. Walle-Gloria, Daniela Rodríguez-Casir, Hugo A. Barrera-Saldaña

Research Symposium

Background: The rapid spread and huge health and economic impact witnessed even from the beginning of the COVID-19 pandemic prompted the development of diagnostic tests to opportunely identify individuals infected by its causing agent, the SARS CoV-2 virus. This is a prerequisite to quarantine them to avoid further spreading the infection specially to their vulnerable co-workers and family contacts. The golden standard for pathogen detection is the Polymerase Chain Reaction (PCR). To obtain an accurate result, it is important to carry out an optimal isolation of the viral RNA genome.

Methods: This study aimed to compare manual (kits of Qiagen …

Knowing The Unknowable: Visions Of Troubled Lands, Estella C. Kuchta

Journal of Contemplative and Holistic Education

This paper describes the author’s clairvoyant visions of war and personal experiences of transrational knowledges. It is an account of one Westerner coming to know outside of and despite Western episteme. Transrational knowing was modelled by companion dogs in the author’s childhood and literary figures in early adulthood, and was experienced as a means of self-protection. Western culture fosters skepticism about transrational knowledges, such as psychic visions and telepathic connections. This paper asserts that transrational knowing—whether between humans, other species, or humans and other species—is a valid and readily available form of knowing that exists outside of and in spite …

Antp Transcriptional Activity Is Modulated By The Formation Of The Trimeric Antp-Tbp Complexes With Tfiieβ, Exd And Bip2, Norma C. Hernández Bautista, Gustavo Jiménez Mejía, Claudia Altamirano Torres, Diana Reséndez Pérez

Research Symposium

Homeoproteins are transcriptional factors that bind to DNA through a highly conserved binding domain known as the homeodomain (HD) which recognizes short regions rich in AT to control the development of the body appendages of organisms. However, their structural and recognition similarities make it difficult to explain how homeoproteins are capable of carrying out their function. Previous results have shown that Antp homeoprotein can establish dimeric interactions with TBP, TFIIEβ, Exd, BIP2 and more recently through BiFC-FRET we confirmed that Antp and TBP can form trimeric complexes with TFIIEβ/Exd/BIP2. Therefore, is important to show how these trimeric complexes modulate Antp …

Antibody Mediated Targeted Drug Delivery System To Improve Immunotherapy In Pancreatic Cancer, Poornima Devi Shaji, Meena Jaggi, Murali M. Yallapu, Subhash C. Chauhan, Sheema Khan

Research Symposium

About 95% of tumor arises from epithelial cell lining ducts known to be pancreatic ductal adenocarcinomas, with less than 5-7% survival rate. Unfortunately, little progress has been seen in the outcomes of patients with PDAC as tumor develops high desmoplasia and chemo-resistance to chemotherapeutic drugs, such as gemcitabine (Gem). Immunotherapy has shown promising results in cancers, except pancreatic cancer due to their characteristic fibrotic tumor microenvironment. The therapies are unable to penetrate to the fibrotic tumors leading to insufficient availability of the therapeutic drugs at the tumor site. A recently identified mucin, MUC13 is aberrantly expressed in pancreatic tumors but …

Soaps And Shampoos: Proposals To Reform Regulation In The United States Personal Care Market To Decrease Deforestation From Palm Oil Imports, Kelsey Weston

Environmental and Earth Law Journal (EELJ)

Palm oil is the world's most highly sought-after vegetable oil due to its multifaceted uses and cheap cost of production. However, producing this versatile oil comes at a high cost to one of the largest biodiversity on the planet. Over the last two centuries, Indonesia and Malaysia have become the main producers and exporters of palm oil but they are also home to the largest number of mammal species in the world that have seen a staggering decline in populations. Furthermore, palm oil production has caused excessive release of greenhouse gases, increased disruption of forestland, and economic poverty for smallholders …

Reversing Quiet Destruction: Florida's Attempt To Regulate Pfas Known As Forever Chemicals, A. Colleen Donald

Environmental and Earth Law Journal (EELJ)

Introduced by manufacturing companies in the 1940s, Per-and polyfluorinated substances (“PFAS”) which consist of a group of over 6,000 chemicals, have insidiously made their way into the bloodstream of humans and into the environment. These nearly indestructible, “forever chemicals” that were once thought to be safe for use in firefighting foams, cosmetics, food packaging, non-stick cookware, and water-resistant clothing, are now found to be toxic. PFAS have been found in animals, aquatic life, and natural resources, and are associated with illnesses in humans: PFAS have been linked to various cancers, reproductive issues in women, and birth defects in children. As …

A Natural Near-Infrared Fluorescent Probe For Cancer Cell Imaging, Benilde E. Adriano, Nycol M. Cotto, Neeraj Chauhan, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu

Research Symposium

Background: Rio Grande Valley (RGV) suffers from a high prevalence of certain cancers and lack the resources for accurate early diagnosis. Near-infrared (NIR) fluorescence-based imaging is a noteworthy and safer strategy for cancer detection compared to radiological imaging. There are several NIR dyes including indocyanine green (ICG) and its analogues that allow high-resolution and deep tissue imaging. However, these dyes possess some drawbacks, namely photo instability, toxicity, poor water solubility, and short half-lives. Chlorophyll (Chl) is a natural dietary and biocompatible NIR fluorescent substance which has the potential to serve as a cancer NIR imaging candidate. Hence, we aim to …

Mortaparibplus- A Novel Anticancer Small Molecule Abrogating Mortalin-P53 Interaction In Cancer Cells, Anissa N. Sari, Ahmed Elwakeel, Jaspreet K. Dhanjal, Vipul Kumar, Durai Sundar, Sunil C. Kaul, Renu Wadhwa

Research Symposium

Background. The cessation of tumor cell growth through cell cycle arrest and apoptosis is determined by p53, a tumor suppressor protein. However, the interaction between mortalin-p53 within cytoplasm/nucleus leads to the inactivation of p53 transcriptional activation function. The disruption of mortalin-p53 complex has been suggested as an approach for developing a potential anticancer drug.

Methods. A screening of a high-content chemical library was performed to determine a molecule with mortalin-p53-interaction disrupting characteristics. After four-rounds of visual assays, we discovered a triazole derivative (4-[(1E)-2-(2-phenylindol-3-yl)-1-azavinyl]-1,2,4-triazole, named Mortaparib^Plus) with a potential ability of disrupting mortalin-p53-complex. In this study, we recruited …

Systems Network Analysis Of Protein Interaction Network (Pin) For Deducing Molecular Mechanistic Action Of Bap Induced Carcinogenesis, Anukriti ., Anupam Dhasmana, Uma Bhardwaj

Research Symposium

Background: Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon, has been placed in group 1 by IARC which indicates that it is a potential carcinogen to human beings. It has shown tumorigenic properties in approximately all animal model systems. In the current study, we have tried to identify the most probable biomolecular targets of BaP using systems biology approach.

Method: All the proteins that interact with BaP were extracted from T3DB. STRING-db was used to generate the Protein- protein interaction network (PPIN). Various apps of cytoscape software were used for network analysis, modulation and GO enrichment analysis. By developing biokinetic …

2023 15th Annual Student Center For Science Engagement Research Symposium, Student Center For Science Engagement

Student Center for Science Engagement Research Symposium

Student presentations in Biology, Chemistry, Physics, Earth Science, Environmental Science, Computer Science, Mathematics, & Psychology

The Student Movement Volume 108 Issue 3: Todos Unidos: Andrews Celebrates Hispanic Heritage Month, Grace No, Nehemiah Sitler, Savannah Tyler, Nathaniel Miller, Katrina Johnson, Nailea Soto, Amelia Stefanescu, Reagan Mccain, Melissa Moore, Andrew Francis, Robert Zhang, Charisse Lapuebla, Katherine Pierre, Caitlin Adap, Rodney Bell Ii, Wambui Karanja

The Student Movement v. 108 (2023-2024)

HUMANS

Hispanic Heritage Month, Grace No

Bigger and Better! Hailey and AUSA Coming With New Events for This Year!, Nehemiah Sitler

Say Hello to Professor Harris, Grace No

Welcome to the Writing Center, Savannah Tyler

ARTS & ENTERTAINMENT

An Evening with Ada Limón, Nathaniel Miller

AU Architecture Program Part I, Katrina Johnson (senior, architecture)

Makarios: Hispanic Expression through Ministry, Nailea Soto

Stitch by Stitch We Cross-Stitch, Amelia Stefanescu

This Semester at HPAC: The Power of Live Music, Reagan McCain

NEWS

AULA Goes Back-to-School, Melissa Moore

International Students Share Thoughts on International Basketball, Andrew Francis

Science Complex Hosts Panel on Faith …

The Beacon, September 29, 2023, Beacon Staff

The Beacon, 2023-2024

Husband and Wife Join NW Faculty; Multicultural Church in Sioux Center; Mitski's melancholic reflection on love; Stereotypical, sappy, sports story falls short; Crafternoon: Creating beauty out of love; Students' candid conversations at The Table; Student Government Association Election Success; Medenwalds enjoy the NW welcome; Dr. Wacker's office stands out, students love it; Multiple cultures, one church; Have people lost all hope?; Social ministry and Jesus; Golf teams playing great season so par; New PRs for NW cross country at Wayne; All NW varsity teams receive NAIA award; Students stirred by communal worship; Celebration of culture, cuisine and contributions;

Volume 1, Issue 5, Bryant University

Bryant Bulldog Bulletin (2023-2024)

No abstract provided.

"The Rat Trap" By Pandora Pound, Andrew Rowan

Tales of WellBeing

The book critically analyzes animal research and argues for greater emphasis on human cell technologies and clinical research.

From Ms2, To You: Advice I Wish I Knew, Caroline Nguyen, Madelina Nguyen

Stimulus: A Medical Humanities Journal

During the Vietnam war, my parents embarked on a dangerous journey across the Pacific Ocean with the hope of a better life. They arrived in America with nothing and faced hardship including poverty and lack of access to healthcare. As a first-generation American, I grew up listening to tough stories of their struggles. It developed in me deep gratitude for their sacrifices and empathy for the underserved population. Although most people in our generation cannot relate to their experience as refugees, we can all relate to the pursuit of wellness in our lives, especially physical health. My motivation to practice …

Effects Of Cortisol, Epinephrine, And Bisphenol Contaminants On The Transcriptional Landscape Of Marine Mammal Blubber, Lauren Kashiwabara, Laura Pirard, Cathy Debier, Daniel Crocker, Jane Khudyakov

Pacific Faculty Work

Top ocean predators such as marine mammals are threatened by intensifying anthropogenic activity, and understanding the combined effects of multiple stressors on their physiology is critical for conservation efforts. We investigated potential interactions between stress hormones and bisphenol contaminants in a model marine mammal, the northern elephant seal (NES). We exposed precision-cut adipose tissue slices (PCATS) from blubber of weaned NES pups to cortisol (CORT), epinephrine (EPI), bisphenol A (BPA), bisphenol S (BPS), or their combinations (CORT-EPI, BPA-EPI, and BPS-EPI) ex vivo and identified hundreds of genes that were differentially regulated in response to these treatments. CORT altered expression of …

Full Issue, The Stimulus Team

Stimulus: A Medical Humanities Journal

No abstract provided.

Chinese Species Of The Genus Tricondyla Latreille, 1822 (Coleoptera: Cicindelidae) And A New Record For The Country, Xinxin Xiong, Jürgen Wiesner

Insecta Mundi

Tricondyla wiesneri Naviaux, 2002 (Coleoptera: Cicindelidae) is reported from China for the first time. Photographs, short descriptions, and an identification key for all six taxa of the genus Tricondyla La­treille, 1822 known from China are given.

The first author recently received several specimens of Tricondyla wiesneri Naviaux, 2002 that had been collected in Yingjiang County, Dehong Dai and Jingpo Autonomous Prefecture, Yunnan Province, China. The second author compared them with the type specimens and confirmed the identification. The species was originally described from Laos, Louang Namtha province (Naviaux 2002: 48), later reported from Vietnam, Dien Bien province (Wiesner 2022: 191), …

The Pepsis Menechma Lepeletier (Hymenoptera: Pompilidae: Pepsinae) Taxonomic And Nomenclatural Problem, Frank E. Kurczewski

Insecta Mundi

Hurd (1952), in revising the Nearctic species of Pepsis Fabricius, separated P. cerberus Lucas from P. elegans Lepeletier based on external morphology and geography. Vardy (2005), in his Western Hemisphere Pepsis revision, combined these taxa and several Neotropical color and structural variants in a broad defini­tion of P. menechma Lepeletier extending across ~11,250 km and two continents. Vardy (2005) synonymized the familiar and well-documented, 160-year-old P. elegans under P. menechma probably because it appeared several pages later in Lepeletier’s (1845) Histoire Naturelle des Insectes. Hyménoptères. Vardy’s (2005) interpre­tation of Pepsis menechma as a viable species presents a taxonomic and …

Establishment Of Sinoxylon Anale Lesne (Coleoptera: Bostrichidae) In Brazil And Its Potential Implications, Luana De Souza Covre, Robert A. Hack, Carlos A.H. Flechtmann

Insecta Mundi

Bostrichidae (Coleoptera) are a family of beetles with specialized xylophagous feeding habits that allow consumption of dry woody plant tissues. Bostrichids are often polyphagous and therefore pose a sig­nificant threat to many agricultural and forestry products, particularly in tropical regions. Bostrichids are commonly detected in solid wood packaging material at international ports of entry. Notably, Sinoxylon anale Lesne has been intercepted in wood crates and pallets worldwide and has now become established in Brazil. This paper reports the first documented establishment of S. anale in Brazil, being found both in domestic wood pallets and within native forest and monoculture. The …

First Report Of The Stinkbug Edessa Leucogramma (Perty) (Hemiptera: Heteroptera: Pentatomidae: Edessinae) Attacking Handroanthus Chrysanthus (Jacq.) S.O. Grose (Bignoniaceae), With Descriptions Of The Adult And Immatures And Notes On Associated Fungi And Protozoa, Gonzalo Abril R., Allan H. Smith-Pardo

Insecta Mundi

The stinkbug Edessa leucogramma (Perty) (Hemiptera: Pentatomidae: Edessinae) is reported as a pest of young yellow guayacán trees (Handroanthus chrysanthus (Jacq.) S.O. Grose, Bignoniaceae) in the met­ropolitan area of the Aburra Valley in Antioquia, Colombia (AMVA). We provide a short description of the adult and immature stages and report for the first-time protozoa associated with the digestive system of this species of true bug in addition to information regarding a fungus found associated with Edessa leucogramma in the field.

Se reporta el chinche Edessa leucograma (Perty) (Hemíptera: Pentatomidae: Edessinae), como plaga importante de árboles jóvenes del guayacán amarillo ( …

Cyclocephala Kuijteni (Scarabaeidae: Dynastinae: Cyclocephalini), A New Species From Suriname, Meindert A. Hielkema

Insecta Mundi

Cyclocephala kuijteni, new species (Scarabaeidae: Dynastinae: Cyclocephalini), is described from Suriname. It is illustrated together with its aedeagus, and the characteristics differentiating it from the most similar species C. castanea (Olivier), C. hardyi Endrödi and C. pygidialis Joly are briefly discussed.

The New World genus Cyclocephala Dejean, 1821 contains about 360 described species, with most representatives occurring in the Neotropics (Ratcliffe and Cave 2015). While investigating the scarabaeoid fauna of Suriname with my son Auke, we collected a large number of Cyclocephala specimens with a so-called mothing sheet, including a single male specimen I was unable to identify. The …

The Diamond, September 29, 2023, Dordt University

Dordt Diamond

• Front Page: Dordt Administration Responds to Increased Tuition; Fifth and Sixth Year Student Athletes Juggle Academics, Sports, and Life; Fred Verwoerd's Dordt Homecoming
• News: Digital Media Department Rebounds from Power Outage; Dordt Admissions Offered Second Annual Latino Visit Day; Student Government Officially in Session
• Feature: Root Plant and Coffee Shop Lattes Hit the Road; Goodbye Butler's, Hello Scooters Coffee; Greg Van Dyke Celebrates the New School Year with an Admissions Award; Production Arts: The Men and Women Behind the Curtain; Dr. Dieleman Joins Dordt Theology Department
• Opinion: Feeding the 5,000 - or Rather, the Hungry College …

Recognizing Handwritten Digits Using Spiking Neural Networks With Learning Algorithms Based On Sliding Mode Control Theory, Yeşi̇m Öni̇z, Mehmet Ayyildiz

Turkish Journal of Electrical Engineering and Computer Sciences

In this paper, a spiking neural network (SNN) has been proposed for recognizing the digits written on the LCD screen of an experimental setup. The convergence of the learning algorithm has been ensured by using sliding mode control (SMC) theory and the Lyapunov stability method for the adaptation of the network parameters. The spike response model (SRM) has been utilized in the design of the SNN. The performance of the proposed learning scheme has been evaluated both on the experimental data and on the MNIST dataset. The simulated and experimental results of the SNN structure have been compared with the …

A Machine Learning Approach For Dyslexia Detection Using Turkish Audio Records, Tuğberk Taş, Muhammed Abdullah Bülbül, Abas Haşi̇moğlu, Yavuz Meral, Yasi̇n Çalişkan, Gunay Budagova, Mücahi̇d Kutlu

Turkish Journal of Electrical Engineering and Computer Sciences

Dyslexia is a learning disorder, characterized by impairment in the ability to read, spell, and decode letters. It is vital to detect dyslexia in earlier stages to reduce its effects. However, diagnosing dyslexia is a time-consuming and costly process. In this paper, we propose a machine-learning model that predicts whether a Turkish-speaking child has dyslexia using his/her audio records. Therefore, our model can be easily used by smart phones and work as a warning system such that children who are likely to be dyslexic according to our model can seek an examination by experts. In order to train and evaluate, …

Creator Biographies, The Stimulus Team

Stimulus: A Medical Humanities Journal

No abstract provided.