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Sustained Antidepressant Effect Of Ketamine Through Nmdar Trapping In The Lhb, Shuangshuang Ma, Christopher J Lingle, Et Al. Oct 2023

Sustained Antidepressant Effect Of Ketamine Through Nmdar Trapping In The Lhb, Shuangshuang Ma, Christopher J Lingle, Et Al.

2020-Current year OA Pubs

Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist

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Short Tandem Repeat Profiling Via Next-Generation Sequencing For Cell Line Authentication, Yi-Hsien Chen, Jon P Connelly, Colin Florian, Xiaoxia Cui, Shondra M Pruett-Miller Oct 2023

Short Tandem Repeat Profiling Via Next-Generation Sequencing For Cell Line Authentication, Yi-Hsien Chen, Jon P Connelly, Colin Florian, Xiaoxia Cui, Shondra M Pruett-Miller

2020-Current year OA Pubs

Cell lines are indispensable models for modern biomedical research. A large part of their usefulness derives from the ability of a cell line to proliferate over multiple passages (often indefinitely), allowing multiple experiments to be performed. However, over time, cell line identity and purity can be compromised by human errors. Cross-contamination from other cell lines and complete misidentification are both possible. Routine cell line authentication is a necessary preventive measure and has become a requirement for many funding applications and publications. Short tandem repeat (STR) profiling is the most common method for cell line authentication and is usually carried out …

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N7-Methylguanosine Methylation Of Trnas Regulates Survival To Stress In Cancer, Raquel García-Vílchez, Ana M Añazco-Guenkova, Judith López, Sabine Dietmann, Mercedes Tomé, Sonia Jimeno, Mikel Azkargorta, Félix Elortza, Laura Bárcena, Monika Gonzalez-Lopez, Ana M Aransay, Manuel A Sánchez-Martín, Pablo Huertas, Raúl V Durán, Sandra Blanco Oct 2023

N7-Methylguanosine Methylation Of Trnas Regulates Survival To Stress In Cancer, Raquel García-Vílchez, Ana M Añazco-Guenkova, Judith López, Sabine Dietmann, Mercedes Tomé, Sonia Jimeno, Mikel Azkargorta, Félix Elortza, Laura Bárcena, Monika Gonzalez-Lopez, Ana M Aransay, Manuel A Sánchez-Martín, Pablo Huertas, Raúl V Durán, Sandra Blanco

2020-Current year OA Pubs

Tumour progression and therapy tolerance are highly regulated and complex processes largely dependent on the plasticity of cancer cells and their capacity to respond to stress. The higher plasticity of cancer cells highlights the need for identifying targetable molecular pathways that challenge cancer cell survival. Here, we show that N

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The Vcam1-Apoe Pathway Directs Microglial Chemotaxis And Alleviates Alzheimer's Disease Pathology, Shun-Fat Lau, Wei Wu, Hiu Yi Wong, Li Ouyang, Yi Qiao, Jiahui Xu, Jessica Hiu-Yan Lau, Carlton Wong, Yuanbing Jiang, David M Holtzman, Amy K Y Fu, Nancy Y Ip Oct 2023

The Vcam1-Apoe Pathway Directs Microglial Chemotaxis And Alleviates Alzheimer's Disease Pathology, Shun-Fat Lau, Wei Wu, Hiu Yi Wong, Li Ouyang, Yi Qiao, Jiahui Xu, Jessica Hiu-Yan Lau, Carlton Wong, Yuanbing Jiang, David M Holtzman, Amy K Y Fu, Nancy Y Ip

2020-Current year OA Pubs

In Alzheimer's disease (AD), sensome receptor dysfunction impairs microglial danger-associated molecular pattern (DAMP) clearance and exacerbates disease pathology. Although extrinsic signals, including interleukin-33 (IL-33), can restore microglial DAMP clearance, it remains largely unclear how the sensome receptor is regulated and interacts with DAMP during phagocytic clearance. Here, we show that IL-33 induces VCAM1 in microglia, which promotes microglial chemotaxis toward amyloid-beta (Aβ) plaque-associated ApoE, and leads to Aβ clearance. We show that IL-33 stimulates a chemotactic state in microglia, characterized by Aβ-directed migration. Functional screening identified that VCAM1 directs microglial Aβ chemotaxis by sensing Aβ plaque-associated ApoE. Moreover, we found …

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Experiences Of The Supervisory Alliance And Self-Compassion In Counseling And Psychotherapy Students, Alexandre Brien, Patricia Dionne, Réginald Savard, Cynthia Bilodeau Sep 2023

Experiences Of The Supervisory Alliance And Self-Compassion In Counseling And Psychotherapy Students, Alexandre Brien, Patricia Dionne, Réginald Savard, Cynthia Bilodeau

Journal of Counselor Preparation and Supervision

This qualitative research examined the relationship between supervisory working alliance, self-compassion and reflexive self-awareness with students enrolled in a graduate-level counseling or counseling and psychotherapy program (n = 48). A thematic analysis using a Critical Incident Questionnaire was performed. The themes identified in this study indicate that both supervision alliance and self-compassion seemingly contribute positively to student supervisee learning experiences and to the development of their reflexive self-awareness. Moreover, the perceived learning achieved, and the development of reflexive self-awareness, reciprocally strengthened the supervisory alliance. Furthermore, the degree of supervisees’ self-compassion as well as their perceived supervisory alliances had an …

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Counselors’ Stigma Toward Addictions: Increasing Awareness And Decreasing Stigma, Natalie M. Ricciutti Sep 2023

Counselors’ Stigma Toward Addictions: Increasing Awareness And Decreasing Stigma, Natalie M. Ricciutti

Journal of Counselor Preparation and Supervision

The purpose of this study was to explore licensed counselors’ level of stigma toward individuals with substance use disorders (SUDs) and process/behavioral addictions (PBAs) and note any differences. A total of 138 licensed mental health counselors from one Midwestern state completed the SRTSS and the BRTSS to determine levels of stigma toward SUDs and PBAs, respectively. Participant scores from the SRTSS and BRTSS were normally distributed, and 15% to 32% of participants’ scores were reflective of stigma toward individuals with either SUDs or PBAs. A significant difference was not found between participants’ stigma toward individuals with SUDs or PBAs. Hypotheses …

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Noticing Instructional Challenges In Artifacts Of Teaching, Tara Barnhart, Elizabeth A. Van Es Sep 2023

Noticing Instructional Challenges In Artifacts Of Teaching, Tara Barnhart, Elizabeth A. Van Es

Education Faculty Articles and Research

This study investigates challenges of enactment teachers notice when analyzing artifacts of teaching in a professional development focused on supporting the enactment of NGSS-aligned modeling instruction. Five secondary science teachers participated in a semester-long video club. Transcripts of the segments of their meetings in which they analyzed artifacts of practice were coded to characterize what they noticed in videos and student work samples from their own and others’ classrooms of students engaging in sensemaking. Through an inductive and iterative approach, three main linguistic challenges were identified related to the teachers’ noticing of students’ disciplinary thinking: learning how to communicate with …

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Vimentin Takes A Hike – Emerging Roles Of Extracellular Vimentin In Cancer And Wound Healing, Sepideh Parvanian, Leila S. Coelho-Rato, Alison E. Patteson, John E. Eriksson Sep 2023

Vimentin Takes A Hike – Emerging Roles Of Extracellular Vimentin In Cancer And Wound Healing, Sepideh Parvanian, Leila S. Coelho-Rato, Alison E. Patteson, John E. Eriksson

Physics - All Scholarship

Vimentin is a cytoskeletal protein important for many cellular processes, including proliferation, migration, invasion, stress resistance, signaling, and many more. The vimentin-deficient mouse has revealed many of these functions as it has numerous severe phenotypes, many of which are found only following a suitable challenge or stress. While these functions are usually related to vimentin as a major intracellular protein, vimentin is also emerging as an extracellular protein, exposed at the cell surface in an oligomeric form or secreted to the extracellular environment in soluble and vesicle-bound forms. Thus, this review explores the roles of the extracellular pool of vimentin …

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South Coast Offshore Crustacean Resource Of Western Australia Harvest Strategy, Department Of Primary Industries And Regional Development, Western Australia Sep 2023

South Coast Offshore Crustacean Resource Of Western Australia Harvest Strategy, Department Of Primary Industries And Regional Development, Western Australia

Fisheries Management Papers

Harvest strategies for aquatic resources in Western Australia (WA) that are managed by the Department of Primary Industries and Regional Development (DPIRD, the Department) are formal documents that ensures decision-making processes are consistent with the principles of Ecologically Sustainable Development (ESD; Fletcher 2002) and Ecosystem Based Fisheries Management (EBFM; Fletcher et al. 2012). The objectives of ESD are reflected in the objects of the Fish Resources Management Act 1994 (FRMA) and the Aquatic Resources Management Act 2016 (ARMA), which is anticipated replace the FRMA once enacted. At this point, the Fish Resources Management Regulations 1995 (FRMR) is also anticipated to …

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Expert Panel Process For Advanced Septic System Technologies, Fb Environmental Associates, Forrest Bell, Cayce Dalton, Bina Skordas, Luke Frankel, Magdalyn Kosalek, Evan Ma Sep 2023

Expert Panel Process For Advanced Septic System Technologies, Fb Environmental Associates, Forrest Bell, Cayce Dalton, Bina Skordas, Luke Frankel, Magdalyn Kosalek, Evan Ma

PREP Reports & Publications

No abstract provided.

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Enhanced Cell Viability And Migration Of Primary Bovine Annular Fibrosus Fibroblast-Like Cells Induced By Microsecond Pulsed Electric Field Exposure, Prince M. Atsu, Connor Mowen, Gary L. Thompson Iii Sep 2023

Enhanced Cell Viability And Migration Of Primary Bovine Annular Fibrosus Fibroblast-Like Cells Induced By Microsecond Pulsed Electric Field Exposure, Prince M. Atsu, Connor Mowen, Gary L. Thompson Iii

Henry M. Rowan College of Engineering Departmental Research

This study is the first to report the enhancement of cell migration and proliferation induced by in vitro microsecond pulsed electric field (μsPEF) exposure of primary bovine annulus fibrosus (AF) fibroblast-like cells. AF primary cells isolated from fresh bovine intervertebral disks (IVDs) are exposed to 10 and 100 μsPEFs with different numbers of pulses and applied electric field strengths. The results indicate that 10 μs-duration pulses induce reversible electroporation, while 100 μs pulses induce irreversible electroporation of the cells. Additionally, μsPEF exposure increased AF cell proliferation up to 150% while increasing the average migration speed by 0.08 μm/min over 24 …

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Pspa-Mediated Aggregation Protects Streptococcus Pneumoniae Against Desiccation On Fomites, Jessica R. Lane, Muralidhar Tata, Rahena Yasmin, Hansol Im, David E. Briles, Carlos J. Orihuela Sep 2023

Pspa-Mediated Aggregation Protects Streptococcus Pneumoniae Against Desiccation On Fomites, Jessica R. Lane, Muralidhar Tata, Rahena Yasmin, Hansol Im, David E. Briles, Carlos J. Orihuela

APC Fund

Streptococcus pneumoniae (Spn) resides in the nasopharynx where it can disseminate to cause disease. One key Spn virulence factor is pneumococcal surface protein A (PspA), which promotes survival by blocking the antimicrobial peptide lactoferricin. PspA has also been shown to mediate attachment to dying epithelial cells in the lower airway due to its binding of cell surface-bound mammalian (m)GAPDH. Importantly, the role of PspA during colonization is not well understood. Wildtype Spn was present in nasal lavage elutes collected from asymptomatically colonized mice at levels ∼10-fold higher that its isogenic PspA-deficient mutant (ΔpspA). Wildtype Spn also …

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Nonlinear Inverse Boundary Value Problem For A Second Order Parabolic Equation With Nonlocal Boundary Conditions, Academy Of Public Administration Under The President Of The Republic Of Azerbaijan, E.I. Azizbayov, Baku State University, Yashar Mehraliyev Sep 2023

Nonlinear Inverse Boundary Value Problem For A Second Order Parabolic Equation With Nonlocal Boundary Conditions, Academy Of Public Administration Under The President Of The Republic Of Azerbaijan, E.I. Azizbayov, Baku State University, Yashar Mehraliyev

Baku Mathematical Journal

The paper studies the classical solvability of an inverse boundary value problem for a second order parabolic equation with nonlocal boundary conditions. For this purpose, first, the considered problem is reduced to an auxiliary equivalent problem in a certain sense. Then, using the Fourier method the auxiliary problem is presented as a system of integral equations. Further, by means of the contraction mappings principle the unique existence of the solution of the obtained system of integral equations is shown. At the end of investigation the existence and uniqueness theorem for the classical solution of the original inverse boundary value problem …

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Operating Fund Budget/ Expenditure Detail Report 2023-24, Csusb Budget Office Sep 2023

Operating Fund Budget/ Expenditure Detail Report 2023-24, Csusb Budget Office

University Budget Office records

No abstract provided.

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Chanticleer | September 2023, Jacksonville State University Sep 2023

Chanticleer | September 2023, Jacksonville State University

Chanticleer

No abstract provided.

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Noticing Instructional Challenges In Artifacts Of Teaching, Tara Barnhart, Elizabeth Van Es Sep 2023

Noticing Instructional Challenges In Artifacts Of Teaching, Tara Barnhart, Elizabeth Van Es

Education Faculty Articles and Research

This study investigates challenges of enactment teachers notice when analyzing artifacts of teaching in a professional development focused on supporting the enactment of NGSS-aligned modeling instruction. Five secondary science teachers participated in a semester-long video club. Transcripts of the segments of their meetings in which they analyzed artifacts of practice were coded to characterize what they noticed in videos and student work samples from their own and others’ classrooms of students engaging in sensemaking. Through an inductive and iterative approach, three main linguistic challenges were identified related to the teachers’ noticing of students’ disciplinary thinking: learning how to communicate with …

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The Impact Of (Trx) Exercises On Developing Certain Physical Abilities For Performing Various Attacks In The Foil Fencing Sport For Female Players Under 20 Years’ Old, Reem Mohammed Abdul-Wahhab, Israa Fouad Salih Sep 2023

The Impact Of (Trx) Exercises On Developing Certain Physical Abilities For Performing Various Attacks In The Foil Fencing Sport For Female Players Under 20 Years’ Old, Reem Mohammed Abdul-Wahhab, Israa Fouad Salih

Modern Sport

The issue of learning and continuously and effectively training skills has become very challenging, especially for individuals under the age of (20). Therefore, the researchers decided to diagnose specific problems based on their expertise in the field. It led them to use (TRX) ropes, which can be easily used anywhere, to physically train the players to address the research problem, which is the weakness of physical abilities that directly affect their performance in various attacks. The study aimed to prepare (TRX) exercises for the research sample and explore the impact of (TRX) exercises on significant certain physical abilities and the …

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Genotype × Environment Interaction For Fibre Quality And Yield Related Traits Under Climatic Conditions Of Dera Ghazi Khan Division, Irum Aziz, Wajad Nazeer, Muhammad Faheem, Maria Basheer, Ali Bukhsh, Nouman Bilal Sep 2023

Genotype × Environment Interaction For Fibre Quality And Yield Related Traits Under Climatic Conditions Of Dera Ghazi Khan Division, Irum Aziz, Wajad Nazeer, Muhammad Faheem, Maria Basheer, Ali Bukhsh, Nouman Bilal

Journal of Bioresource Management

Cotton (Gossypium hirsutum L.) is a fibre and oilseed crop and offers raw materials to industries and livelihood for the rural poor. During the last decade, climate change has negatively affected crop production all over the world. Under such scenarios of climate change, plant breeders must explore the genetics of crops for better yield and fibre quality. Considering the extent of cotton in Pakistan's economy, the present research was planned to evaluate six cotton varieties in different locations for yield stability. Six varieties namely IUB-13, CIM-600, S-32, FH-Lalazar, CIM-616 and Z-33 were surveyed at farmer fields in Rajan Pur, …

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Extraction And Characterization Of Fibres From The Bark Of Ficus Nekbudu Tree, Liberato V Haule Sep 2023

Extraction And Characterization Of Fibres From The Bark Of Ficus Nekbudu Tree, Liberato V Haule

Tanzania Journal of Engineering and Technology (TJET)

This paper investigates the extraction and characterization of fibres from the bark of the ficus nekbudu tree. The Ficus Nekbudu Fibres (FNF) was extracted from the bark by retting in water and then treatment with sodium hydroxide solution. The extracted FNF was analysed for chemical composition, physical, tensile, surface, structural and thermal stability properties. Findings on the chemical composition indicated that FNF has cellulose (49.9 %), lignin (13.4%), ash (7.1%) and water content (8.1%). From the physical investigation it was found that FNF has density (1.42 ± 0.005 g/cm3) and moisture regain (9.2 ±0.3%). From mechanical investigation it was found …

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The Effect Of Tabata Exercises On The Development Of Stamina And Achievement For Female Athletes Running 100m Hurdles Under The Age Of 18 Years, Lamyaa Ayad Kareem, Zainab Qahtan Abdul-Mohsen Sep 2023

The Effect Of Tabata Exercises On The Development Of Stamina And Achievement For Female Athletes Running 100m Hurdles Under The Age Of 18 Years, Lamyaa Ayad Kareem, Zainab Qahtan Abdul-Mohsen

Modern Sport

The science of modern sports training is a scientific educational process based on sound foundations, and its goal is for the players to reach integration in the technical performance. And devices to achieve high sporting achievements, and the two researchers used a modern method of sports training methods in order to develop strength endurance and achievement for the 100m hurdles event female players under 18 years old. The importance of the study lies in the use of Tabata exercises, which are among the modern exercises that are characterized by suspense and excitement, and their application according to specific times in …

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The Effect Of Rehabilitative Exercises Preceded By An Electrical Stimulation Device For Working Muscles In Relieving Lower Back Pain For Women Aged (25-35) Years, Anaam Jaafar Sadiq, Bushra Kadhim Abdul-Ridha Sep 2023

The Effect Of Rehabilitative Exercises Preceded By An Electrical Stimulation Device For Working Muscles In Relieving Lower Back Pain For Women Aged (25-35) Years, Anaam Jaafar Sadiq, Bushra Kadhim Abdul-Ridha

Modern Sport

The importance of the research lies in: The effect of rehabilitative exercises accompanying the electrical stimulation device for working muscles in relieving lower back pain for women aged (25-35) years and identifying the extent of the effect of these exercises in relieving lower back pain. The research problem lies as a result of technological progress, as the individual's movement became less and less, which made him\her more vulnerable to injuries, which led to an increase in the number of women with lower back pain, and the negative effects of those pains on their practical and psychological lives, which prompted the …

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Exploring The Correlation Between Metacognitive Skills And Cognitive Learning Outcomes Across Various Biology Learning Models In High Schools, Ninik Kristiani, Herawati Susilo, Aloysius Duran Corebim, Fatchur Rohman Sep 2023

Exploring The Correlation Between Metacognitive Skills And Cognitive Learning Outcomes Across Various Biology Learning Models In High Schools, Ninik Kristiani, Herawati Susilo, Aloysius Duran Corebim, Fatchur Rohman

Jurnal Pendidikan Sains

In Malang City, a notable observation within the realm of high school biology education suggests a prevalent lack of metacognitive knowledge among teachers, hindering their efficacy in nurturing students' metacognitive capacities. Such deficiency yields implications for diminished cognitive abilities among students. Recognizing this, there emerges a pressing need for an enhanced pedagogical framework capable of fostering metacognitive skills adeptly. One promising approach involves integrating inquiry-based learning and problem- based mindful pedagogy (PBMP). This amalgamation is anticipated to synergistically harness the potential of both methodologies in bolstering metacognitive skills alongside cognitive learning outcomes. This study adopts a correlational research design, wherein …

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Analysis And Unraveling Misconceptions: Examining Tenth-Grade High School Students’ Errors In Hots Questions On Exponential Equations And Effective Scaffolding Strategies, Nunik Indayani, Erry Hidayanto, Sisworo Sisworo Sep 2023

Analysis And Unraveling Misconceptions: Examining Tenth-Grade High School Students’ Errors In Hots Questions On Exponential Equations And Effective Scaffolding Strategies, Nunik Indayani, Erry Hidayanto, Sisworo Sisworo

Jurnal Pendidikan Sains

The objective of this study is to elucidate the errors made by tenth-grade students at SMA Hati Bilingual Boarding School Probolinggo, Indonesia, when tackling Higher Order Thinking Skills (HOTS) questions on exponential equations, along with the scaffolding process employed to mitigate these errors. Employing qualitative research methods, four participants were chosen based on their performance in completing HOTS questions on exponential equations, followed by in-depth interviews. The identified student errors encompass basic errors, appropriate errors, missing information, and partial insights. The analysis aligns these errors predominantly with Brodie’s error taxonomy. Furthermore, the study highlights the efficacy of instructional scaffolding, utilizing …

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Analysis Of Student Engagement And Perceptions Of Community Of Inquiry (Coi)-Based Blended Learning In The Chemical Separation Subject On Chromatography, Agita Dzulhajh Anggraini, Surjani Wonorahardjo, Yudhi Utomo Sep 2023

Analysis Of Student Engagement And Perceptions Of Community Of Inquiry (Coi)-Based Blended Learning In The Chemical Separation Subject On Chromatography, Agita Dzulhajh Anggraini, Surjani Wonorahardjo, Yudhi Utomo

Jurnal Pendidikan Sains

Learning in higher education has often been conducted solely through face-to-face, teacher- centered approaches. Implementing Community of Inquiry (CoI)-based blended learning in chromatography is crucial as it offers students a novel learning experience. This pre- experimental study, utilizing a one-group pretest-posttest design, aimed to describe students’ perceptions of CoI-based blended learning in chromatography. Data were collected using a questionnaire comprising 34 statements. The results indicated that students had a neutral perception of CoI-based blended learning. While a community of inquiry has been established, it has not yet reached its full potential, as students have not fully experienced social presence in …

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The Identification Of Students’ Conceptual Mastery Of Fluid Statics: An Overview Of Gender, Maria Claudia Sodakain, Sentot Kusairi, Nandang Mufti, Jane Koswojo Sep 2023

The Identification Of Students’ Conceptual Mastery Of Fluid Statics: An Overview Of Gender, Maria Claudia Sodakain, Sentot Kusairi, Nandang Mufti, Jane Koswojo

Jurnal Pendidikan Sains

This study aimed to assess the conceptual mastery of fluid statics among students, employing a descriptive quantitative approach. The research involved 22 male and 13 female students from eleventh-grade MIPA at a private school in Surabaya, Indonesia. The primary research instrument comprised 11 multiple-choice and reasoning questions, covering concepts related to Pressure and Hydrostatic Pressure, Pascal’s Law, and Archimedes’ Principle. Results indicated a higher level of conceptual mastery among male students compared to their female counterparts. While both genders demonstrated relatively high conceptual mastery in Pressure and Hydrostatic Pressure, significant disparities were observed in their understanding of Pascal’s Law and …

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Neural Mechanisms For The Localization Of Unexpected External Motion, Suma Chinta, Scott R. Pluta Sep 2023

Neural Mechanisms For The Localization Of Unexpected External Motion, Suma Chinta, Scott R. Pluta

Purdue University Libraries Open Access Publishing Fund

To localize objects during active sensing, animals must differentiate stimuli caused by volitional movement from real-world object motion. To determine a neural basis for this ability, we examined the mouse superior colliculus (SC), which contains multiple egocentric maps of sensorimotor space. By placing mice in a whisker-guided virtual reality, we discovered a rapidly adapting tactile response that transiently emerged during externally generated gains in whisker contact. Responses to self-generated touch that matched self-generated history were significantly attenuated, revealing that transient response magnitude is controlled by sensorimotor predictions. The magnitude of the transient response gradually decreased with repetitions in external motion, …

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The Role Of Non-Coding Rnas In Myelodysplastic Neoplasms, Vasileios Georgoulis, Epameinondas Koumpis, Eleftheria Hatzimichael Sep 2023

The Role Of Non-Coding Rnas In Myelodysplastic Neoplasms, Vasileios Georgoulis, Epameinondas Koumpis, Eleftheria Hatzimichael

Computational Medicine Center Faculty Papers

Myelodysplastic syndromes or neoplasms (MDS) are a heterogeneous group of myeloid clonal disorders characterized by peripheral blood cytopenias, blood and marrow cell dysplasia, and increased risk of evolution to acute myeloid leukemia (AML). Non-coding RNAs, especially microRNAs and long non-coding RNAs, serve as regulators of normal and malignant hematopoiesis and have been implicated in carcinogenesis. This review presents a comprehensive summary of the biology and role of non-coding RNAs, including the less studied circRNA, siRNA, piRNA, and snoRNA as potential prognostic and/or predictive biomarkers or therapeutic targets in MDS.

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Purification And Characterization Of Mitochondrial Mg2+-Independent Sphingomyelinase From Rat Brain, Jong Min Choi, Yongwei Piao, Kyong Hoon Ahn, Seok Kyun Kim, Jong Hoon Won, Jae Hong Lee, Ji Min Jang, In Chul Shin, Zhicheng Fu, Sung Yun Jung, Eui Man Jeong, Dae Kyong Kim Sep 2023

Purification And Characterization Of Mitochondrial Mg2+-Independent Sphingomyelinase From Rat Brain, Jong Min Choi, Yongwei Piao, Kyong Hoon Ahn, Seok Kyun Kim, Jong Hoon Won, Jae Hong Lee, Ji Min Jang, In Chul Shin, Zhicheng Fu, Sung Yun Jung, Eui Man Jeong, Dae Kyong Kim

Faculty, Staff and Students Publications

Sphingomyelinase (SMase) catalyzes ceramide production from sphingomyelin. Ceramides are critical in cellular responses such as apoptosis. They enhance mitochondrial outer membrane permeabilization (MOMP) through self-assembly in the mitochondrial outer membrane to form channels that release cytochrome c from intermembrane space (IMS) into the cytosol, triggering caspase-9 activation. However, the SMase involved in MOMP is yet to be identified. Here, we identified a mitochondrial Mg

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Existing Evidence For Influenza B Virus Adaptations To Drive Replication In Humans As The Primary Host, Matthew J. Pekarek, Eric A. Weaver Sep 2023

Existing Evidence For Influenza B Virus Adaptations To Drive Replication In Humans As The Primary Host, Matthew J. Pekarek, Eric A. Weaver

Nebraska Center for Virology: Faculty Publications

Influenza B virus (IBV) is one of the two major types of influenza viruses that circulate each year. Unlike influenza A viruses, IBV does not harbor pandemic potential due to its lack of historical circulation in non-human hosts. Many studies and reviews have highlighted important factors for host determination of influenza A viruses. However, much less is known about the factors driving IBV replication in humans. We hypothesize that similar factors influence the host restriction of IBV. Here, we compile and review the current understanding of host factors crucial for the various stages of the IBV viral replication cycle. While …

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Did Cover Crop Or Animal Manure Ameliorate Corn Residue Removal Effects On Soil Mechanical Properties After 10 Years?, Hans W. Klopp, Humberto Blanco-Canqui, Michael Sindelar, Virginia L. Jin, Marty R. Schmer, Richard B. Ferguson Sep 2023

Did Cover Crop Or Animal Manure Ameliorate Corn Residue Removal Effects On Soil Mechanical Properties After 10 Years?, Hans W. Klopp, Humberto Blanco-Canqui, Michael Sindelar, Virginia L. Jin, Marty R. Schmer, Richard B. Ferguson

Department of Agronomy and Horticulture: Faculty Publications

Crop residue removal may negatively affect soil mechanical properties, which are key components of soil quality. To evaluate potential long-term effects, we assessed the 10-yr impact of corn (Zea mays L.) residue removal (59 % of non-grain biomass annually) on surface soil mechanical properties (0–20 cm). We also evaluated whether adding carbon (C) amendments, such as using a winter rye (Secale cereale L.) cover crop or surface-applying cattle manure (24 Mg ha− 1 biannually) can ameliorate the effects of crop residue removal. This long-term study was under irrigated no-till continuous corn on a silt loam soil in south-central …

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