Digital Commons Network^™

What's Your Type? The Relationship Between Enneagram Personality Style And Psychiatric Diagnosis, Danielle Augusta Huber

Theses and Dissertations

Despite its long history and ever-growing popularity amongst mental health providers and laypeople, the Enneagram model of personality has seen limited empirical support regarding its clinical relevance and efficacy. The present study sought to contribute to the literature supporting the Enneagram’s use in psychotherapy. As a majority of therapeutic services aim for the reduction and/or resolution of psychopathology, often in terms of one or more diagnoses, and as previous research has theorized how the Enneagram model and psychiatric diagnoses might be related (Palmer, 1988), it was the researchers’ intention to analyze whether these theoretical associations could be statistically supported. This …

Scalable Nanopore Sequencing Of Human Genomes Provides A Comprehensive View Of Haplotype-Resolved Variation And Methylation, Mikhail Kolmogorov, Kimberley J Billingsley, Mira Mastoras, Melissa Meredith, Jean Monlong, Ryan Lorig-Roach, Mobin Asri, Pilar Alvarez Jerez, Laksh Malik, Ramita Dewan, Xylena Reed, Rylee M Genner, Kensuke Daida, Sairam Behera, Kishwar Shafin, Trevor Pesout, Jeshuwin Prabakaran, Paolo Carnevali, Jianzhi Yang, Arang Rhie, Sonja W Scholz, Bryan J Traynor, Karen H Miga, Miten Jain, Winston Timp, Adam M Phillippy, Mark Chaisson, Fritz J Sedlazeck, Cornelis Blauwendraat, Benedict Paten

Faculty, Staff and Students Publications

Long-read sequencing technologies substantially overcome the limitations of short-reads but have not been considered as a feasible replacement for population-scale projects, being a combination of too expensive, not scalable enough or too error-prone. Here we develop an efficient and scalable wet lab and computational protocol, Napu, for Oxford Nanopore Technologies long-read sequencing that seeks to address those limitations. We applied our protocol to cell lines and brain tissue samples as part of a pilot project for the National Institutes of Health Center for Alzheimer's and Related Dementias. Using a single PromethION flow cell, we can detect single nucleotide polymorphisms with …

Short Tandem Repeat Profiling Via Next-Generation Sequencing For Cell Line Authentication, Yi-Hsien Chen, Jon P Connelly, Colin Florian, Xiaoxia Cui, Shondra M Pruett-Miller

2020-Current year OA Pubs

Cell lines are indispensable models for modern biomedical research. A large part of their usefulness derives from the ability of a cell line to proliferate over multiple passages (often indefinitely), allowing multiple experiments to be performed. However, over time, cell line identity and purity can be compromised by human errors. Cross-contamination from other cell lines and complete misidentification are both possible. Routine cell line authentication is a necessary preventive measure and has become a requirement for many funding applications and publications. Short tandem repeat (STR) profiling is the most common method for cell line authentication and is usually carried out …

Biomechanical Adaptations While Performing Bilateral Drop Landings With A Unilateral Ankle Tape Application, Eric Daniel Jenkins

Rehabilitation Sciences Theses & Dissertations

Ankle sprains are the most common injury in sport and exercise performance, which makes the utilization of ankle taping a common procedure to both prevent potential sprain, as well as protect against reinjury. However, unilateral ankle taping may have unintended consequences on the mechanics of the ankle and other joints of both legs. The aim of this dissertation was to determine the effects of ankle taping on lower body kinetics and kinematics, stiffness, and coordination during a bilateral landing task.

Twelve female participants completed a total of 90 drop landings across two visits, randomized from landing platforms of 30, 45, …

Best Practices For Effective Management Of Point Of Care Testing, Anil K Chokkalla, Brandy D Recio, Sridevi Devaraj

Faculty, Staff and Students Publications

With the recent COVID-19 pandemic, point-of-care testing has gained tremendous attention, particularly in acute care settings. The point-of-care testing landscape is rapidly expanding and being contemplated for any crucial test with a central laboratory turnaround time >25% of the clinical decision time. A typical point-of-care testing program within a large hospital system encompasses a multitude of operators utilizing a wide range of devices across multiple testing sites. Thus, managing a large point-of-care testing network remains a daunting task with challenges related to staffing, standardization, quality management, training and competency assessment, and data management. This review will focus on understanding the …

Prevalence Of Pathogenic Germline Variants In Adult-Type Diffuse Glioma, Malcolm F Mcdonald, Lyndsey L Prather, Cassandra R Helfer, Ethan B Ludmir, Alfredo E Echeverria, Shlomit Yust-Katz, Akash J Patel, Benjamin Deneen, Ganesh Rao, Ali Jalali, Shweta U Dhar, Chris I Amos, Jacob J Mandel

Faculty, Staff and Students Publications

BACKGROUND: No consensus germline testing guidelines currently exist for glioma patients, so the prevalence of germline pathogenic variants remains unknown. This study aims to determine the prevalence and type of pathogenic germline variants in adult glioma.

METHODS: A retrospective review at a single institution with paired tumor/normal sequencing from August 2018-April 2022 was performed and corresponding clinical data were collected.

RESULTS: We identified 152 glioma patients of which 15 (9.8%) had pathogenic germline variants. Pathogenic germline variants were seen in 11/84 (13.1%) of Glioblastoma, IDH wild type; 3/42 (7.1%) of Astrocytoma, IDH mutant; and 1/26 (3.8%) of Oligodendroglioma, IDH mutant, …

Machine Learning Approach To Activity Categorization In Young Adults Using Biomechanical Metrics, Nathan Q. C. Holland

Mechanical & Aerospace Engineering Theses & Dissertations

Inactive adults often have decreased musculoskeletal health and increased risk factors for chronic diseases. However, there is limited data linking biomechanical measurements of generally healthy young adults to their physical activity levels assessed through questionnaires. Commonly used data collection methods in biomechanics for assessing musculoskeletal health include but are not limited to muscle quality (measured as echo intensity when using ultrasound), isokinetic (i.e., dynamic) muscle strength, muscle activations, and functional movement assessments using motion capture systems. These assessments can be time consuming for both data collection and processing. Therefore, understanding if all biomechanical assessments are necessary to classify the activity …

An Interdisciplinary Approach To Experiential Learning In Cyberbiosecurity And Agriculture Through Workforce Development, Kellie Johnson, Tiffany Drape, Joseph Oakes, Joseph J. Simpson, Anne Brown, Donna M. Westfall-Rudd, Susan Duncan

International Business and Entrepreneurship Faculty Publications

Cyberbiosecurity and workforce development in agriculture and the life sciences (ALS) is a growing area of need in the curriculum in higher education. Students that pursue majors related to ALS often do not include training in cyber-related concepts or expose the ‘hidden curriculum’ of seeking internships and jobs. Exposing students through workforce development training and hands-on engagement with industry professionals can provide learning opportunities to bridge the two and is an area of growth and demand as the workforce evolves. The objectives of this work were 1) to learn key concepts in cybersecurity, including data security, visualization, and analysis, to …

Meeting The Demand For Fertility Services: The Present And Future Of Reproductive Endocrinology And Infertility In The United States, Eduardo Hariton, Ruben Alvero, Micah J Hill, Jennifer E Mersereau, Shana Perman, David Sable, Fiona Wang, Geoffrey David Adamson, Christos Coutifaris, Latasha B Craig, Pardis Hosseinzadeh, Anthony N Imudia, Erica B Johnstone, Ruth B Lathi, Paul C Lin, Erica E Marsh, Michele Munch, Gloria Richard-Davis, Lauren W Roth, Amy K Schutt, Kim Thornton, Lauren Verrilli, Rachel S Weinerman, Steven L Young, Kate Devine

Faculty, Staff and Students Publications

The field of reproductive endocrinology and infertility (REI) is at a crossroads; there is a mismatch between demand for reproductive endocrinology, infertility and assisted reproductive technology (ART) services, and availability of care. This document's focus is to provide data justifying the critical need for increased provision of fertility services in the United States now and into the future, offer approaches to rectify the developing physician shortage problem, and suggest a framework for the discussion on how to meet that increase in demand. The Society of REI recommend the following: 1. Our field should aggressively explore and implement courses of action …

A Novel Pathogenic Mutation Of Mecp2 Impairs Chromatin Association Independent Of Protein Levels, Jian Zhou, Claudia Cattoglio, Yingyao Shao, Harini P Tirumala, Carlo Vetralla, Sameer S Bajikar, Yan Li, Hu Chen, Qi Wang, Zhenyu Wu, Bing Tang, Mahla Zahabiyon, Aleksandar Bajic, Xiangling Meng, Jack J Ferrie, Anel Lagrone, Ping Zhang, Jean J Kim, Jianrong Tang, Zhandong Liu, Xavier Darzacq, Nathaniel Heintz, Robert Tjian, Huda Y Zoghbi

Faculty, Staff and Students Publications

Loss-of-function mutations in MECP2 cause Rett syndrome (RTT), a severe neurological disorder that mainly affects girls. Mutations in MECP2 do occur in males occasionally and typically cause severe encephalopathy and premature lethality. Recently, we identified a missense mutation (c.353G>A, p.Gly118Glu [G118E]), which has never been seen before in MECP2, in a young boy who suffered from progressive motor dysfunction and developmental delay. To determine whether this variant caused the clinical symptoms and study its functional consequences, we established two disease models, including human neurons from patient-derived iPSCs and a knock-in mouse line. G118E mutation partially reduces MeCP2 abundance …

The Vcam1-Apoe Pathway Directs Microglial Chemotaxis And Alleviates Alzheimer's Disease Pathology, Shun-Fat Lau, Wei Wu, Hiu Yi Wong, Li Ouyang, Yi Qiao, Jiahui Xu, Jessica Hiu-Yan Lau, Carlton Wong, Yuanbing Jiang, David M Holtzman, Amy K Y Fu, Nancy Y Ip

2020-Current year OA Pubs

In Alzheimer's disease (AD), sensome receptor dysfunction impairs microglial danger-associated molecular pattern (DAMP) clearance and exacerbates disease pathology. Although extrinsic signals, including interleukin-33 (IL-33), can restore microglial DAMP clearance, it remains largely unclear how the sensome receptor is regulated and interacts with DAMP during phagocytic clearance. Here, we show that IL-33 induces VCAM1 in microglia, which promotes microglial chemotaxis toward amyloid-beta (Aβ) plaque-associated ApoE, and leads to Aβ clearance. We show that IL-33 stimulates a chemotactic state in microglia, characterized by Aβ-directed migration. Functional screening identified that VCAM1 directs microglial Aβ chemotaxis by sensing Aβ plaque-associated ApoE. Moreover, we found …

Antibody Response To Sars-Cov-2 Vaccines In Patients With Relapsing Multiple Sclerosis Treated With Evobrutinib: A Bruton's Tyrosine Kinase Inhibitor, Amit Bar-Or, Anne H Cross, Anthony L Cunningham, Yann Hyvert, Andrea Seitzinger, Hans Gühring, Elise E Drouin, Nektaria Alexandri, Davorka Tomic, Xavier Montalban

2020-Current year OA Pubs

BACKGROUND: Evobrutinib is an oral, central nervous system (CNS)-penetrant and highly selective covalent Bruton's tyrosine kinase inhibitor under clinical development for patients with relapsing multiple sclerosis (RMS).

OBJECTIVE: To investigate the effect of evobrutinib on immune responses in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinated patients with RMS from a Phase II trial (NCT02975349).

METHODS: A

RESULTS: In the vaccinated subgroup, mean/minimum evobrutinib exposure pre-vaccination was 105.2/88.7 weeks. In total, 43 of 45 patients developed/increased S1/S2 IgG antibody levels post-vaccination; one patient's antibody response remained negative post-vaccination and the other had antibody levels above the upper limit of detection, …

Clinical Classification Of Variants In The Valosin-Containing Protein Gene Associated With Multisystem Proteinopathy, Marianela Schiava, Jil Daw, Conrad Chris Weihl, Et Al.

2020-Current year OA Pubs

BACKGROUND AND OBJECTIVES: Pathogenic variants in the valosin-containing protein (

METHODS: A 6-item clinical score was developed to evaluate the phenotypic level of evidence to support the pathogenicity of the novel variants. Each item is allocated a value, a score ranging from 0.5 to 5.5 points. A receiver-operating characteristic curve was used to identify a cutoff value of 3 to consider a variant as high likelihood disease associated. The scoring system results were confronted with results of in vitro ATPase activity assays and with in silico analysis.

RESULTS: All variants were missense, except for one small deletion-insertion, 18 led to …

Experiences Of The Supervisory Alliance And Self-Compassion In Counseling And Psychotherapy Students, Alexandre Brien, Patricia Dionne, Réginald Savard, Cynthia Bilodeau

Journal of Counselor Preparation and Supervision

This qualitative research examined the relationship between supervisory working alliance, self-compassion and reflexive self-awareness with students enrolled in a graduate-level counseling or counseling and psychotherapy program (n = 48). A thematic analysis using a Critical Incident Questionnaire was performed. The themes identified in this study indicate that both supervision alliance and self-compassion seemingly contribute positively to student supervisee learning experiences and to the development of their reflexive self-awareness. Moreover, the perceived learning achieved, and the development of reflexive self-awareness, reciprocally strengthened the supervisory alliance. Furthermore, the degree of supervisees’ self-compassion as well as their perceived supervisory alliances had an …

Counselors’ Stigma Toward Addictions: Increasing Awareness And Decreasing Stigma, Natalie M. Ricciutti

Journal of Counselor Preparation and Supervision

The purpose of this study was to explore licensed counselors’ level of stigma toward individuals with substance use disorders (SUDs) and process/behavioral addictions (PBAs) and note any differences. A total of 138 licensed mental health counselors from one Midwestern state completed the SRTSS and the BRTSS to determine levels of stigma toward SUDs and PBAs, respectively. Participant scores from the SRTSS and BRTSS were normally distributed, and 15% to 32% of participants’ scores were reflective of stigma toward individuals with either SUDs or PBAs. A significant difference was not found between participants’ stigma toward individuals with SUDs or PBAs. Hypotheses …

Noticing Instructional Challenges In Artifacts Of Teaching, Tara Barnhart, Elizabeth A. Van Es

Education Faculty Articles and Research

This study investigates challenges of enactment teachers notice when analyzing artifacts of teaching in a professional development focused on supporting the enactment of NGSS-aligned modeling instruction. Five secondary science teachers participated in a semester-long video club. Transcripts of the segments of their meetings in which they analyzed artifacts of practice were coded to characterize what they noticed in videos and student work samples from their own and others’ classrooms of students engaging in sensemaking. Through an inductive and iterative approach, three main linguistic challenges were identified related to the teachers’ noticing of students’ disciplinary thinking: learning how to communicate with …

Vimentin Takes A Hike – Emerging Roles Of Extracellular Vimentin In Cancer And Wound Healing, Sepideh Parvanian, Leila S. Coelho-Rato, Alison E. Patteson, John E. Eriksson

Physics - All Scholarship

Vimentin is a cytoskeletal protein important for many cellular processes, including proliferation, migration, invasion, stress resistance, signaling, and many more. The vimentin-deficient mouse has revealed many of these functions as it has numerous severe phenotypes, many of which are found only following a suitable challenge or stress. While these functions are usually related to vimentin as a major intracellular protein, vimentin is also emerging as an extracellular protein, exposed at the cell surface in an oligomeric form or secreted to the extracellular environment in soluble and vesicle-bound forms. Thus, this review explores the roles of the extracellular pool of vimentin …

South Coast Offshore Crustacean Resource Of Western Australia Harvest Strategy, Department Of Primary Industries And Regional Development, Western Australia

Fisheries Management Papers

Harvest strategies for aquatic resources in Western Australia (WA) that are managed by the Department of Primary Industries and Regional Development (DPIRD, the Department) are formal documents that ensures decision-making processes are consistent with the principles of Ecologically Sustainable Development (ESD; Fletcher 2002) and Ecosystem Based Fisheries Management (EBFM; Fletcher et al. 2012). The objectives of ESD are reflected in the objects of the Fish Resources Management Act 1994 (FRMA) and the Aquatic Resources Management Act 2016 (ARMA), which is anticipated replace the FRMA once enacted. At this point, the Fish Resources Management Regulations 1995 (FRMR) is also anticipated to …

Expert Panel Process For Advanced Septic System Technologies, Fb Environmental Associates, Forrest Bell, Cayce Dalton, Bina Skordas, Luke Frankel, Magdalyn Kosalek, Evan Ma

PREP Reports & Publications

No abstract provided.

Enhanced Cell Viability And Migration Of Primary Bovine Annular Fibrosus Fibroblast-Like Cells Induced By Microsecond Pulsed Electric Field Exposure, Prince M. Atsu, Connor Mowen, Gary L. Thompson Iii

Henry M. Rowan College of Engineering Departmental Research

This study is the first to report the enhancement of cell migration and proliferation induced by in vitro microsecond pulsed electric field (μsPEF) exposure of primary bovine annulus fibrosus (AF) fibroblast-like cells. AF primary cells isolated from fresh bovine intervertebral disks (IVDs) are exposed to 10 and 100 μsPEFs with different numbers of pulses and applied electric field strengths. The results indicate that 10 μs-duration pulses induce reversible electroporation, while 100 μs pulses induce irreversible electroporation of the cells. Additionally, μsPEF exposure increased AF cell proliferation up to 150% while increasing the average migration speed by 0.08 μm/min over 24 …

Pspa-Mediated Aggregation Protects Streptococcus Pneumoniae Against Desiccation On Fomites, Jessica R. Lane, Muralidhar Tata, Rahena Yasmin, Hansol Im, David E. Briles, Carlos J. Orihuela

APC Fund

Streptococcus pneumoniae (Spn) resides in the nasopharynx where it can disseminate to cause disease. One key Spn virulence factor is pneumococcal surface protein A (PspA), which promotes survival by blocking the antimicrobial peptide lactoferricin. PspA has also been shown to mediate attachment to dying epithelial cells in the lower airway due to its binding of cell surface-bound mammalian (m)GAPDH. Importantly, the role of PspA during colonization is not well understood. Wildtype Spn was present in nasal lavage elutes collected from asymptomatically colonized mice at levels ∼10-fold higher that its isogenic PspA-deficient mutant (ΔpspA). Wildtype Spn also …

Nonlinear Inverse Boundary Value Problem For A Second Order Parabolic Equation With Nonlocal Boundary Conditions, Academy Of Public Administration Under The President Of The Republic Of Azerbaijan, E.I. Azizbayov, Baku State University, Yashar Mehraliyev

Baku Mathematical Journal

The paper studies the classical solvability of an inverse boundary value problem for a second order parabolic equation with nonlocal boundary conditions. For this purpose, first, the considered problem is reduced to an auxiliary equivalent problem in a certain sense. Then, using the Fourier method the auxiliary problem is presented as a system of integral equations. Further, by means of the contraction mappings principle the unique existence of the solution of the obtained system of integral equations is shown. At the end of investigation the existence and uniqueness theorem for the classical solution of the original inverse boundary value problem …

Operating Fund Budget/ Expenditure Detail Report 2023-24, Csusb Budget Office

University Budget Office records

No abstract provided.

Chanticleer | September 2023, Jacksonville State University

Chanticleer

No abstract provided.

Noticing Instructional Challenges In Artifacts Of Teaching, Tara Barnhart, Elizabeth Van Es

Education Faculty Articles and Research

This study investigates challenges of enactment teachers notice when analyzing artifacts of teaching in a professional development focused on supporting the enactment of NGSS-aligned modeling instruction. Five secondary science teachers participated in a semester-long video club. Transcripts of the segments of their meetings in which they analyzed artifacts of practice were coded to characterize what they noticed in videos and student work samples from their own and others’ classrooms of students engaging in sensemaking. Through an inductive and iterative approach, three main linguistic challenges were identified related to the teachers’ noticing of students’ disciplinary thinking: learning how to communicate with …

The Impact Of (Trx) Exercises On Developing Certain Physical Abilities For Performing Various Attacks In The Foil Fencing Sport For Female Players Under 20 Years’ Old, Reem Mohammed Abdul-Wahhab, Israa Fouad Salih

Modern Sport

The issue of learning and continuously and effectively training skills has become very challenging, especially for individuals under the age of (20). Therefore, the researchers decided to diagnose specific problems based on their expertise in the field. It led them to use (TRX) ropes, which can be easily used anywhere, to physically train the players to address the research problem, which is the weakness of physical abilities that directly affect their performance in various attacks. The study aimed to prepare (TRX) exercises for the research sample and explore the impact of (TRX) exercises on significant certain physical abilities and the …

Genotype × Environment Interaction For Fibre Quality And Yield Related Traits Under Climatic Conditions Of Dera Ghazi Khan Division, Irum Aziz, Wajad Nazeer, Muhammad Faheem, Maria Basheer, Ali Bukhsh, Nouman Bilal

Journal of Bioresource Management

Cotton (Gossypium hirsutum L.) is a fibre and oilseed crop and offers raw materials to industries and livelihood for the rural poor. During the last decade, climate change has negatively affected crop production all over the world. Under such scenarios of climate change, plant breeders must explore the genetics of crops for better yield and fibre quality. Considering the extent of cotton in Pakistan's economy, the present research was planned to evaluate six cotton varieties in different locations for yield stability. Six varieties namely IUB-13, CIM-600, S-32, FH-Lalazar, CIM-616 and Z-33 were surveyed at farmer fields in Rajan Pur, …

Extraction And Characterization Of Fibres From The Bark Of Ficus Nekbudu Tree, Liberato V Haule

Tanzania Journal of Engineering and Technology (TJET)

This paper investigates the extraction and characterization of fibres from the bark of the ficus nekbudu tree. The Ficus Nekbudu Fibres (FNF) was extracted from the bark by retting in water and then treatment with sodium hydroxide solution. The extracted FNF was analysed for chemical composition, physical, tensile, surface, structural and thermal stability properties. Findings on the chemical composition indicated that FNF has cellulose (49.9 %), lignin (13.4%), ash (7.1%) and water content (8.1%). From the physical investigation it was found that FNF has density (1.42 ± 0.005 g/cm3) and moisture regain (9.2 ±0.3%). From mechanical investigation it was found …

The Effect Of Tabata Exercises On The Development Of Stamina And Achievement For Female Athletes Running 100m Hurdles Under The Age Of 18 Years, Lamyaa Ayad Kareem, Zainab Qahtan Abdul-Mohsen

Modern Sport

The science of modern sports training is a scientific educational process based on sound foundations, and its goal is for the players to reach integration in the technical performance. And devices to achieve high sporting achievements, and the two researchers used a modern method of sports training methods in order to develop strength endurance and achievement for the 100m hurdles event female players under 18 years old. The importance of the study lies in the use of Tabata exercises, which are among the modern exercises that are characterized by suspense and excitement, and their application according to specific times in …

The Effect Of Rehabilitative Exercises Preceded By An Electrical Stimulation Device For Working Muscles In Relieving Lower Back Pain For Women Aged (25-35) Years, Anaam Jaafar Sadiq, Bushra Kadhim Abdul-Ridha

Modern Sport

The importance of the research lies in: The effect of rehabilitative exercises accompanying the electrical stimulation device for working muscles in relieving lower back pain for women aged (25-35) years and identifying the extent of the effect of these exercises in relieving lower back pain. The research problem lies as a result of technological progress, as the individual's movement became less and less, which made him\her more vulnerable to injuries, which led to an increase in the number of women with lower back pain, and the negative effects of those pains on their practical and psychological lives, which prompted the …