Digital Commons Network^™

New Insights Into The Neuraminidase-Mediated Hemagglutination Activity Of Influenza A(H3n2) Viruses, Rongyuan Gao, Philippe Noriel Q Pascua, Ha T Nguyen, Anton Chesnokov, Chloe Champion, Vasiliy P Mishin, Dave E Wentworth, Larisa V Gubareva

Faculty, Staff and Student Publications

Influenza virus neuraminidase (NA) can act as a receptor-binding protein, a role commonly attributed to hemagglutinin (HA). In influenza A(H3N2) viruses, three NA amino acid residues have previously been associated with NA-mediated hemagglutination: T148, D151, and more recently, H150. These residues are part of the 150-loop of the NA monomer. Substitutions at 148 and 151 arise from virus propagation in laboratory cell cultures, whereas changes at 150 occurred during virus evolution in the human host. In this study, we examined the effect of natural amino acid polymorphism at position 150 on NA-mediated hemagglutination. Using the A/Puerto Rico/8/34 backbone, we generated …

The Emerging Importance Of Mitochondria In White Adipocytes: Neither Last Nor Least, Juan Cai, Fenfen Wang, Mengle Shao

Faculty, Staff and Student Publications

The growing recognition of mitochondria's crucial role in the regulation of white adipose tissue remodeling and energy balance underscores its significance. The marked metabolic diversity of mitochondria provides the molecular and cellular foundation for enabling adipose tissue plasticity in response to various metabolic cues. Effective control of mitochondrial function at the cellular level, not only in thermogenic brown and beige adipocytes but also in energy-storing white adipocytes, exerts a profound influence on adipose homeostasis. Furthermore, mitochondria play a pivotal role in intercellular communication within adipose tissue via production of metabolites with signaling properties. A more comprehensive understanding of mitochondrial regulation …

X, But Not Y, Chromosomal Complement Contributes To Stroke Sensitivity In Aged Animals, Shaohua Qi, Conelius Ngwa, Abdullah Al Mamun, Sharmeen Romana, Ting Wu, Sean P Marrelli, Arthur P Arnold, Louise D Mccullough, Fudong Liu

Faculty, Staff and Student Publications

Post-menopausal women become vulnerable to stroke and have poorer outcomes and higher mortality than age-matched men, and previous studies suggested that sex chromosomes play a vital role in mediating stroke sensitivity in the aged. It is unknown if this is due to effects of the X or Y chromosome. The present study used the XY* mouse model (with four genotypes: XX and XO gonadal females and XY and XXY gonadal males) to compare the effect of the X vs. Y chromosome compliment in stroke. Aged (18-20 months) and gonadectomized young (8-12 weeks) mice were subjected to a 60-min middle cerebral …

Correction To “Inhibition Of Hyaluronan Synthesis Attenuates Pulmonary Hypertension Associated With Lung Fibrosis”, Harry Karmouty-Quintana

Faculty, Staff and Student Publications

No abstract provided.

Attention-Based Human Age Estimation From Face Images To Enhance Public Security, Md. Ashiqur Rahman, Shuhena S. Aonty, Kaushik Deb, Iqbal H. Sarker

Research outputs 2022 to 2026

Age estimation from facial images has gained significant attention due to its practical applications such as public security. However, one of the major challenges faced in this field is the limited availability of comprehensive training data. Moreover, due to the gradual nature of aging, similar-aged faces tend to share similarities despite their race, gender, or location. Recent studies on age estimation utilize convolutional neural networks (CNN), treating every facial region equally and disregarding potentially informative patches that contain age-specific details. Therefore, an attention module can be used to focus extra attention on important patches in the image. In this study, …

Physical-Vapor-Deposited Metal Oxide Thin Films For Ph Sensing Applications: Last Decade Of Research Progress, Mohammad Nur-E-Alam, Devendra K. Maurya, Boon K. Yap, Armin Rajabi, Camellia Doroody, Hassan B. Mohamed, Mayeen U. Khandaker, Mohammad A. Islam, Sieh K. Tiong

Research outputs 2022 to 2026

In the last several decades, metal oxide thin films have attracted significant attention for the development of various existing and emerging technological applications, including pH sensors. The mandate for consistent and precise pH sensing techniques has been increasing across various fields, including environmental monitoring, biotechnology, food and agricultural industries, and medical diagnostics. Metal oxide thin films grown using physical vapor deposition (PVD) with precise control over film thickness, composition, and morphology are beneficial for pH sensing applications such as enhancing pH sensitivity and stability, quicker response, repeatability, and compatibility with miniaturization. Various PVD techniques, including sputtering, evaporation, and ion beam …

Spontaneous Collapse As A Prognostic Marker For Human Blastocysts: A Systematic Review And Meta-Analysis, Kate Bickendorf, Fang Qi, Kelli Peirce, Jay Natalwala, Vincent Chapple, Yanhe Liu

Research outputs 2022 to 2026

STUDY QUESTION: Is spontaneous collapse (SC) by human blastocysts a prognostic factor in IVF treatment? SUMMARY ANSWER: SC in human blastocyst is associated with reduced euploid embryo and pregnancy rates. WHAT IS KNOWN ALREADY: SC of the human blastocyst is a phenomenon that was revealed relatively recently following the clinical application of time-lapse monitoring in IVF laboratories. The ploidy and clinical prognosis of affected blastocysts are still poorly understood, with inconsistent reports. Systematic reviews and meta-analyses on this topic are currently absent in the literature but its potential as a marker of embryo viability holds great clinical value. In this …

An Unusual Presentation Of Pigmented Purpuric Lichenoid Dermatitis, Christine De Antonis, Jordan T. Hyde, Jason B. Lee, Sylvia Hsu

Department of Dermatology and Cutaneous Biology Faculty Papers

Pigmented purpuric lichenoid dermatitis (PPLD) is a rare subtype of pigmented purpuric dermatosis, which classically presents with a mixture of lichenoid papules and patches on the bilateral lower extremities. Herein, we describe an unusual case of a 47-year-old man with PPLD who presented with 1-3mm discrete papules without the presence of larger patches. The diagnosis of PPLD should be considered for patients presenting with bilateral symmetric discrete papules on the legs.

Virus Control Aboard A Commuter Bus, Hamid Rahai, Jeremy Bonifacio

Mineta Transportation Institute

A major health concern for public transit users is exposure to viruses from other passengers. This numerical study examines virus containment aboard a public bus with changes to the bus ventilation system. The virus was modeled as a 2.5 µm round solid particle released from the mouth of the infectious passenger at a rate of 21 particles per second at a mouth velocity of 0.278 m/sec. The air delivery to the cabin was two linear ceiling slots spanning the length of the bus delivering 59.38 m3/min (2,097 CFM) of air at a mean velocity of 1 m/sec. Two different axial …

Dipl 3104 Public International Law, Catherine Tinker Phd

Diplomacy Syllabi

This course explores the history and nature of international law and how international law and courts address selected issues currently challenging the global community. The course will focus broadly on the creation and implementation of international law; global governance and diplomacy; and rules or practices in international relations between and among states and between states and non-state actors, including individuals and international or regional organizations.

The course introduces and examines the traditional sources of international law and the actors of international law through history and developments up to the present. The creation of international law will be examined through treaties, …

Is Conventional Colonoscopy More Effective Than Computed Tomography Colonography In The Screening Of Colorectal Cancer Among Young African American Adults?, Abena Abrafi Nimako

Electronic Theses and Dissertations

Healthcare journalist Brenda Goodman’s article on CNN Health on October 10, 2022, about a new study examining the effectiveness of colonoscopies, essentially concluded that the efficacy of conventional colonoscopy is in question. This research sought to establish whether conventional colonoscopy is more effective than computed tomography (CT) colonography in screening colorectal cancer among young African American adults. The researcher employed a literature review and a case-control research design to gather data on the subject. Data were collected from literature, the SEER database, the CDC, and the American Cancer Society websites. The study sample consisted of African Americans between the ages …

2023 October, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for October of 2023.

A Review On Antibacterial Activity Of Nanoparticles, Badr-Edine Sadoq, Mohammed Reda Britel, Adel Bouajaj, Ramzi Maâlej, Ahmed Touhami, Marwa Abid, Hanen Douiri, Fakhita Touhami, Amal Maurady

Physics & Astronomy Faculty Publications

The increasing resistance of bacteria to antibiotic agents is a main global public health problem. The use of nanoparticles is one of the promising ways to overcome microbial resistance to antimicrobial agents. Metal nanoparticles are increasingly used to target bacterial strains. Advances in nanotechnology, in particular the ability to synthesize nanoparticles of specific size and shape, are likely to lead to the development of new antibacterial agents. The antibacterial activities of nanoparticles are largely influenced by their sizes and large surface area/mass ratio. The antibacterial mechanisms of nanoparticles are poorly understood, but the currently accepted mechanisms include oxidative stress induction, …

The Vermont Family Based Approach In Primary Care Pediatrics: Effects On Children’S And Parents’ Emotional And Behavioral Problems And Parents’ Health-Related Quality Of Life, Masha Y. Ivanova, Allison Hall, Stanley Weinberger, Sara L. Buckingham, William E. Copeland, Phoenix Crockett, Justin Dainer-Best, Casey D'Alberto, Lauren Dewey, Deshan Foret, Maria Galano, Lisa Goodrich, Lindsay E. Holly, Nalini Lane, Maureen Leahey, Mathew Lerner, Jasime Marsh, Ellen Mcginnis, Melissa Paiva-Salisbury, Judith S. Shaw, Pamela Swift, Rebekah Tinker, James J. Hudziak

Psychology Faculty Research and Publications

This randomized controlled trial tested the Vermont Family Based Approach (VFBA) in primary care pediatrics. The VFBA is a model of healthcare delivery that shifts the focus from the individual to the family, emphasizes emotional and behavioral health, and uses evidence-based health promotion/prevention along with the treatment of emotional and behavioral problems. Participants were 81 families of 3–15-year-olds. For children, the VFBA was associated with greater reductions than the Control condition on the Child Behavior Checklist Emotionally Reactive, Withdrawn, Sleep Problems, Aggressive Behavior and Total Problems scales. For parents, the VFBA was associated with greater reductions than the Control condition …

When Planetary Cosmopolitanism Meets The Buddhist Ethic: Recycling, Karma And Popular Ecology In Singapore, Siew Ying Shee, Orlando Woods, Lily Kong

Research Collection College of Integrative Studies

By thinking with and through Buddhist cosmology, this paper explores the emergence of an ethical sensibility—what we call planetary cosmopolitanism—that is based on not just a spatially expanded ethic of care to ecological worlds, but also a temporally extended sense of justice to the future Earth. This transtemporal sense of ethical becoming reflects how the possibility of future ‘rebirth’ and accountability for past actions can motivate new ecological consciousness in the present. We forge these ideas through an empirical focus on popular Buddhist ecological practices in Singapore, where green recovery visions have primarily been driven by a secular and technocratic …

Why Do Farmers’ Cooperatives Fail In A Market Economy? Rediscovering Chayanov With The Chinese Experience, Zhanping Hu, Qian Forrest Zhang, John A. Donaldson

Research Collection School of Social Sciences

In The Theory of Peasant Cooperatives, Chayanov develops the theories of differential optima and vertical integration, which stress the vulnerability of peasant farming in capitalist markets, and argues that cooperatives can support smallholders only if they operate as ‘a cooperative movement’, are buttressed by a strong ‘cooperative culture’, and achieve ‘vertical integration’. Based on extensive fieldwork in China, we identify six major obstacles that explain the failure of most cooperatives. Chayanov’s arguments caution us to not only the vital importance of cooperatives to the resilience of peasant farming, but also the apparently insurmountable obstacles that cooperatives face in market economies.

Social Anhedonia, Communication And Marital Satisfaction In Newlywed Couples, Kenneth Tan, Amber M. Jarnecke, Susan C. South

Research Collection School of Social Sciences

Objective: Social anhedonia is associated with disinterest in social interactions and poor relationship functioning, yet little is known about the specific mechanisms underlying associations between social anhedonia and romantic relationship behaviors and satisfaction. We examined the links between social anhedonia, perceptions of conflict communication patterns, and marital satisfaction. Method: The current research examined the role of social anhedonia on marital quality and functioning longitudinally across a year in a sample of 100 newlywed couples using an actor-partner interdependence framework. Results: Social anhedonia was negatively associated with own and partner's marital satisfaction. It was also negatively associated with constructive communication and …

Cross-Group Differences In Age, Period, And Cohort Effects: A Bounding Approach To The Gender Wage Gap, Ohjae Gowen, Ethan Fosse, Christopher Winship

Research Collection School of Social Sciences

For decades, researchers have sought to understand the separate contributions of age, period, and cohort (APC) on a wide range of outcomes. However, a major challenge in these efforts is the linear dependence among the three time scales. Previous methods have been plagued by either arbitrary assumptions or extreme sensitivity to small variations in model specification. In this article, we present an alternative method that achieves partial identification by leveraging additional information about subpopulations (or strata) such as race, gender, and social class. Our first goal is to introduce the cross-strata linearized APC (CSL-APC) model, a re-parameterization of the traditional …

Broodmother: What The Lack Of Bathroom Breaks Reveals About Dehumanizing Teachers, Jonathan Michael Coker

Educational Leadership

This chapter asks, “What is it like to be a public school teacher in a school that doesn't allow for adequate bathroom breaks?” Using van Manen's interpretive phenomenological methodology, the authors analyzed interviews from nine participants to create an empathetic portrayal of teachers who have inadequate bathroom breaks. These experiences were then distilled into a series of insights through the concept of “broodmothering.” These broodmothers deny their own physical and mental needs in the interest of supervising children, and show a profession burdened by increasing parentification and dehumanization of teachers. After connecting this phenomenon to larger issues in the profession, …

Quantitative Multiplexed Imaging Technologies For Single-Cell Analysis To Assess Predictive Markers For Immunotherapy In Thoracic Immuno-Oncology: Promises And Challenges, Edwin Roger Parra, Marius Ilié, Ignacio I Wistuba, Paul Hofman

Faculty, Staff and Student Publications

The past decade has witnessed a revolution in cancer treatment by the shift from conventional drugs (chemotherapies) towards targeted molecular therapies and immune-based therapies, in particular the immune-checkpoint inhibitors (ICIs). These immunotherapies selectively release the host immune system against the tumour and have shown unprecedented durable remission for patients with cancers that were thought incurable such as advanced non-small cell lung cancer (aNSCLC). The prediction of therapy response is based since the first anti-PD-1/PD-L1 molecules FDA and EMA approvals on the level of PD-L1 tumour cells expression evaluated by immunohistochemistry, and recently more or less on tumour mutation burden in …

Clinical And Biological Significance Of Circulating Mirnas In Chronic Pancreatitis Patients Undergoing Total Pancreatectomy With Islet Autotransplantation, Srividya Vasu, Giovanna Saracino, Carly M Darden, Kenjiro Kumano, Yang Liu, Michael C Lawrence, Bashoo Naziruddin

Faculty, Staff and Student Publications

Background: Specific microRNAs (miRNAs) were elevated in chronic pancreatitis (CP) patients during islet infusion after total pancreatectomy (TPIAT). We aimed to identify circulating miRNA signatures of pancreatic damage, predict miRNA-mRNA networks to identify potential links to CP pathogenesis and identify islet isolation and transplantation functional outcomes.

Methods: Small RNA sequencing was performed to identify distinct circulating miRNA signatures in CP. Plasma miRNAs were measured using miRCURY LNA SYBR green quantitative real-time polymerase chain reaction assays. Correlation analyses were performed using R software. The miRNA target and disease interactions were determined using miRNet and the miRNA enrichment and annotation tool.

Results: …

Third-Party Reactions To Performance Feedback, Daroon Mohammed Jalil

Psychology Theses & Dissertations

Although the provision of feedback has traditionally been treated as a dyadic event, I argue for the existence of a neglected third-party - the witness. Drawing from the dual process model of vicarious mistreatment and feedback intervention theory, I hypothesize that 1) third parties experience negative [positive] affect when witnessing an unjust [just] feedback event, 2) negative [positive] affect is stronger when feedback cues are self-referenced [task-referenced], and 3) negative [positive] affect is related to a subsequent decrease [increase] in feedback seeking intentions. Results from a 2x2 between-subjects experiment with 470 participants provide partial support for the hypotheses. Third-parties experienced …

Nightmares And Self-Injury Among High-Risk Adolescents: Examining The Role Of Emotion Regulation, Kinjal K. Patel

Psychology Theses & Dissertations

Self-injurious thoughts and behaviors (SITBs) are a public health concern among youth. SITB rates rise drastically during adolescence -- a critical and sensitive developmental period characterized by dramatic changes in biological and social systems. Prior research has identified distal risk factors which tell us who is at risk for SITBs. Emerging research suggests proximal risk factors may be useful to identify when an individual may be at risk for SITBs. One promising proximal risk factor for SITBs is sleep problems. Although the relation between sleep problems and SITBs has been widely documented, little is known about the short-term, proximal links …

A New View Of Chlorophyll Dynamics In The Southern Mid-Atlantic Bight From A Two-Year High-Resolution Spray Glider Survey, Francesco Lane

OES Theses and Dissertations

The southern Mid-Atlantic Bight (MAB) near Cape Hatteras, NC, USA, is likely a hotspot for the episodic export of carbon-rich shelf waters to the open ocean. Over a 2 year period, from March 2017 to May 2019, Spray gliders repeatedly occupied transects, along the slope and across the shelf, generating high-resolution chlorophyll fluorescence (fChl) data in the southern MAB. This study implements an fChl calibration method utilizing remotely sensing ocean color as a standard. We validate the method’s utility by demonstrating a reduction in post-calibration cross-mission fChl variability and demonstrating close correspondence between the calibrated fChl data and an in …

Relationship Between Learning Communities And Campus Residency On Sense Of Belonging Among First Year Undergraduates, Lanah Kathryn Stafford

Educational Leadership & Workforce Development Theses & Dissertations

In higher education, sense of belonging has been linked to improved outcomes such as retention and academic achievement (e,g., Pittman & Richmond, 2007). Previous research has also identified participation in learning communities and campus residency as interventions which improve sense of belonging for students in this context (e.g., Solanki et al., 2019; Soria & Roberts, 2021). However, little research has been conducted to empirically study sense of belonging as a multidimensional construct, and no research has investigated interactions between on-campus residency and learning community participation on its development.

Data were collected from 1,072 first-year students on the Sense of Belonging …

Help-Seeking Behavior Among Resettled Refugee, Mahfoudha Sid’Elemine

Graduate Program in International Studies Theses & Dissertations

The refugee resettlement process is a huge part of refugees’ journeys in their new countries that has a lasting impact on their long-term integration. The literature highlights the importance of trust for successful refugee resettlement. This dissertation, however, challenges assumptions about the primary importance of “trust” and argues that the importance of trust is relative and can depend on the nature of the resettlement program and the perspective and background of refugees. In other words, there is not a one-size-fits-all of trust building in the context of resettlement. For certain resettlement programs trust building can be counterproductive when resources are …

Organic Carbon Decay Mediated By Mesopelagic Microbial Communities, Noah Jonathan Craft

OES Theses and Dissertations

Substantial remineralization of organic carbon occurs in the mesopelagic zone (i.e., the biological pump), the efficiency of which is responsible for the oceans’ capacity to store carbon originally derived from the atmosphere. To better understand how a substrate’s composition influences its degradation by mesopelagic microbial communities, we added treatments made of live algal cells, dead particulate organic carbon and dissolved organic carbon from ¹⁴C-labeled algal cultures to mesopelagic water collected in-situ. Each incubation took place in the laboratory over a period of months, during which PO¹⁴C, DO¹⁴C, ATP, prokaryote abundances and biochemical fractions were measured. …

Pulsed Electric Field Ablation: Mechanisms Of Differential Cell Sensitivity And Methods To Mitigate Neuromuscular Excitation, Emily Gudvangen

Biomedical Engineering Theses & Dissertations

Ablation therapies aim to destroy tumors while maintaining minimal damage to surrounding healthy tissue. Pulsed electric field (PEF) ablation targets the cell membrane during the destruction of tissues, which consequently spares extracellular structures such as ducts and blood vessels, leaving the framework for tissue regeneration. However, the utility of PEF is limited by neuromuscular excitation, causing pain and involuntary muscle contraction. To identify PEF protocols that efficiently ablate tissue while minimizing neuromuscular stimulation, various PEF protocols differing in pulse duration, shape, and repetition rate were tested. The ratio of cell death and nerve excitation thresholds, which determines the range of …

The Effects Of Self-Regulated Learning On Community College Students Metacognition, Motivation And Achievement In Geoscience Courses, Melani A. Loney

Educational Leadership & Workforce Development Theses & Dissertations

This study investigated the impact of training in self-regulated learning on community college, geoscience students’ achievement, metacognition, time management, and science motivation scales. The study also investigated the impact of SRL training on these outcomes as a function of gender and ethnicity. During the Fall of 2022, 70 community college geoscience students from 9 different classes participated in the study. The classes were bifurcated with one half of the students in each class randomly assigned to the SRL treatment and the other half to the control condition. Each week, for 10 weeks during the semester, students in the treatment group …

Dental Hygiene Students Reported Physiological Symptoms Associated With Wearing An N95 Respirator Mask, Peyton Shea Butler

Dental Hygiene Theses & Dissertations

Purpose: Physiological symptoms and comfort levels while wearing an N95 respiratory mask has not been examined with dental hygienists. The purpose of this study was to investigate dental hygiene students reported physiological symptoms and comfort perception while wearing an N95 respirator mask during patient care appointments. Methods: After IRB approval (IRB #1987754-2), a 16-item questionnaire was distributed through email to a convenience sample of 65 dental hygiene students. Questions assessed respiratory, dermatologic, cardiac, mask mouth and general physiological symptoms, as well as comfort levels. Additionally, participants were asked to respond to demographic questions and one open ended question inquiring about …