Digital Commons Network^™

Association Of Prolactin With All-Cause And Cardiovascular Mortality Among Patients With Type 2 Diabetes: A Real-World Study, Yun Shen, Qing Yang, Tingting Hu, Yaxin Wang, Lei Chen, Fei Gao, Wei Zhu, Gang Hu, Jian Zhou, Chunfang Wang, Yuqian Bao

Population and Public Health Science Faculty Publications

Aims The association between prolactin and mortality has been less studied, and findings were inconsistent among different populations. We aimed to investigate the association between serum prolactin (PRL) and mortality among patients with type 2 diabetes. Methods We performed a retrospective cohort study of 10 907 patients with at least 2 prolactin measurements within 2 years since and results their first inpatient diagnosis of type 2 diabetes. Baseline and mean values of serum PRL were used as exposures. A multivariable-adjusted Cox proportional hazards model was used to estimate the association between PRL and mortality. During a mean follow-up of 5.34 …

Rare Variants Found In Multiplex Families With Orofacial Clefts: Does Expanding The Phenotype Make A Difference?, Kimberly K Diaz Perez, Sydney Chung, S Taylor Head, Michael P Epstein, Jacqueline T Hecht, George L Wehby, Seth M Weinberg, Jeffrey C Murray, Mary L Marazita, Elizabeth J Leslie

Faculty, Staff and Student Publications

Exome sequencing (ES) is now a relatively straightforward process to identify causal variants in Mendelian disorders. However, the same is not true for ES in families where the inheritance patterns are less clear, and a complex etiology is suspected. Orofacial clefts (OFCs) are highly heritable birth defects with both Mendelian and complex etiologies. The phenotypic spectrum of OFCs may include overt clefts and several subclinical phenotypes, such as discontinuities in the orbicularis oris muscle (OOM) in the upper lip, velopharyngeal insufficiency (VPI), microform clefts or bifid uvulas. We hypothesize that expanding the OFC phenotype to include these phenotypes can clarify …

Specialized Astrocytes Mediate Glutamatergic Gliotransmission In The Cns, Roberta De Ceglia, Ada Ledonne, David Gregory Litvin, Barbara Lykke Lind, Giovanni Carriero, Emanuele Claudio Latagliata, Erika Bindocci, Maria Amalia Di Castro, Iaroslav Savtchouk, Ilaria Vitali, Anurag Ranjak, Mauro Congiu, Tara Canonica, William Wisden, Kenneth Harris, Manuel Mameli, Nicola Mercuri, Ludovic Telley, Andrea Volterra

Biomedical Sciences Faculty Research and Publications

Multimodal astrocyte–neuron communications govern brain circuitry assembly and function. For example, through rapid glutamate release, astrocytes can control excitability, plasticity and synchronous activity of synaptic networks, while also contributing to their dysregulation in neuropsychiatric conditions. For astrocytes to communicate through fast focal glutamate release, they should possess an apparatus for Ca2+-dependent exocytosis similar to neurons. However, the existence of this mechanism has been questioned owing to inconsistent data and a lack of direct supporting evidence. Here we revisited the astrocyte glutamate exocytosis hypothesis by considering the emerging molecular heterogeneity of astrocytes and using molecular, bioinformatic and imaging approaches, together with …

Suny Cortland Handbook 2023, State University Of New York College At Cortland

SUNY Cortland Handbook

No abstract provided.

Disentangling Sex Differences In Ptsd Risk Factors: A Systematic Overview And Multiple Mediation Analysis The The Aurora Study, Stephanie Haering, Antonia V. Seligowski, Sarah Linnstaedt, Vasiliki Michopoulos, Stacey L. House, Francesca Beaudoin, Xinming An, Thomas C. Neylan, Gari Clifford, Robert A. Swor

Articles

No abstract provided.

Review Essay: Enjoyment And Ideology Surplus-Enjoyment: A Guide For The Non-Perplexed Slavoj Žižek. London: Bloomsbury Academic. 2022. Pp. 400., Edward Sankowski, Betty J. Harris

International Dialogue

Slavoj Žižek’s Surplus-Enjoyment-A Guide for the Non-Perplexed is a difficult book. Reading it requires a different approach from what is usual with what seems to us more standardized philosophical or social scientific prose. Our approach initially at least no doubt assumes as our starting point a deploying of our shared norms, shaped by our backgrounds as U.S. based scholars aiming to advance dialogue with Žižek and some of the wide variety of authors with whom Žižek himself engages.

A Profile Of Freshman Inquiry Students Fall 2023, Rowanna L. Carpenter

University Studies Assessment Research

In order to better understand the students enrolled in Freshman Inquiry (FRINQ) courses and identify areas where they may need support, University Studies (UNST) began collecting and compiling data on these students. This report presents a profile of FRINQ students from Fall 2023. It presents an overview of all students enrolled in FRINQ during Fall 2023 and then summarizes information from the Prior Learning Survey.

Politics By Other Means: The Jurisprudence Of “Common Good Constitutionalism”, Brian Leiter

University of Chicago Law Review

Professor Adrian Vermeule proposes an alternative to what he sees as the two dominant schools of constitutional interpretation in the United States: originalism and what he usually calls “progressivism”¹ (by which he means what others call “living constitutionalism”² ). Against these approaches, he advocates for what Freudians might call a “return of the repressed”³: a recognition of the extent to which the “classical” natural law tradition’s concern with the “common good” has continued to animate our public law—explicitly for much of our history, he says, and implicitly more recently.

On Vermeule’s proposed alternative, courts (and other …

Optimizing Crop Productivity And Fertility Practices In Intermediate Wheatgrass, Roberta Bianchin Rebesquini

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

The intensive management associated with many annual crops often includes recurring tillage, fertilization, and pesticide applications, which contribute to environmental concerns such as water pollution and soil erosion. Intermediate wheatgrass (Thinopyrum intermedium), recognized under the trade name Kernza®, is a perennial grass that can be managed to produce grain and biomass while providing desired environmental benefits such as soil conservation and nutrient cycling. There has been limited research on best management practices and crop productivity for this alternative dual-use crop in Nebraska. A field experiment was conducted beginning in 2021 to assess nitrogen (N), phosphorus (P), and potassium …

Vaccine Development, The China Dilemma, And International Regulatory Challenges, Peter K. Yu

Faculty Scholarship

This article examines the role played by China in the development of international regulatory standards at the intersection of intellectual prop- erty, international trade, and public health. It begins by briefly discussing the role China has played in the global health arena during the COVID-19 pandemic. The article then highlights the difficulty in determining how best to engage with the country in the development of new international regula- tory standards. It shows that the preferred method of engagement will likely depend on one’s perspective on China’s potential contributions and hin- drances: a perspective that focuses on global competition—in the economic, …

What Do Law Professors Believe About Law And The Legal Academy?, Eric H. Martinez, Kevin Tobia

Faculty Scholarship

Legal scholarship is replete with debates about competing legal theories: textualism or purposivism; formalism or realism; natural law or positivism; prison reform or abolition; universal or culturally specific human rights? Despite voluminous literature about these debates, great uncertainty remains about which views experts endorse. This Article presents the first dataset of American law professors’ views about legal theory. A study of over six hundred law professors reveals expert consensus and dissensus about dozens of longstanding debates.

Law professors also debate questions about the legal academy. These include descriptive questions: Which subjects (for example, constitutional law) and methods (for example, law …

Ischemia Modified Albumin In Maternal Serum And Cord Blood In Relation To Preeclampsia Severity And Neonatal Outcome, Sarah Sulaiman, Maha Jasim Al-Bayati

Iraqi Postgraduate Medical Journal

BACKGROUND:Preeclampsia is associated with ischemia and increased oxidative stress in the placenta. Ischemia-modified albumin has been widely accepted as a serological biomarker in preeclampsia.OBJECTIVE:To evaluate the relationship between maternal serum and cord blood ischemia modified albumin levels with preeclampsia severity and neonatal outcome.PATIENTS AND METHODS:This study includes 90 pregnant women who were divided into three groups: Group 1 includes 30 pregnant women with severe preeclampsia. Group 2 includes 30 pregnant women with mild preeclampsia. Group 3 includes 30 normotensive pregnant women with uncomplicated pregnancy considered as control group. The three groups were matched for age and gestational age. Maternal blood …

The Validity Of Mri And Mrv In Diagnosis Of Pseudotumor Cerebri, Mahmood Ahmed, Hasan Al-Hamadani, Noor Hummadi

Iraqi Postgraduate Medical Journal

BACKGROUND: Pseudotumor cerebri (PTC) is an entity of uncertain cause recognized by increased intracranial pressure. The diagnosis rely on clinical symptoms, absence of structural, hydrocephalus, , vascular or intracranial mass lesion on imaging, increased cerebrospinal fluid pressure measured by lumbar puncture, and normal CSF composition. MRI (magnetic resonance image) and MRV (magnetic resonance venography) findings have been reported to be associated with Pseudotumor cerebri.OBJECTIVE:To assess the validity of individual magnetic resonance imaging (cross-sectional and venographic) signs associated with PTC and determine whether the gathering of cross sectional magnetic resonance image and magnetic resonance venography findings enhances the PTC diagnostic certainty.PATIENTS …

Evaluation Of Synchronous Metastatic Colonic Cancer Management; Single Center Experience; Short Term Outcome, Yesor Abd-Al Razzaq Albadri, Mohamed Abbass, Aqeel Mahmood

Iraqi Postgraduate Medical Journal

BACKGROUND:Colorectal cancer is the fourth most frequently diagnosed cancer after lung, breast and prostate cancer, and the second leading cause of cancer death after lung cancer globally. Sometimes, distant metastases can cause the initial clinical symptoms. Synchronous metastatic colon cancer define as initially presented metastatic disease.OBJECTIVE:To evaluate the clinical presentations of patients with synchronous metastatic colon cancer, the outcome of current chemotherapy protocols used and their toxicity in our center for those  patients , and to correlate the different clinical and pathological parameters in patients with this disease .  PATIENTS AND METHODS:This is a hospital based prospective study would hold …

Cancer Of Unknown Primary Origin: Incidence Trend And Athological Features, Iraq, 2005-2019, Ola Shaker, Faris Lami, Nada Alwan

Iraqi Postgraduate Medical Journal

BACKGROUND:Cancer of unknown primary origin is an obscure group of diagnoses in which the primary anatomical site of tumor origin is not specified.OBJECTIVE: This study aimed to determine the trend of cancer of unknown primary origin in Iraq in the period from 2005 to 2019 at the national and governorate level and its pathological characteristics.METHODS:The data was compiled from the cancer registry of Iraq for the period 2005-2019 and from Al Amal Cancer Hospital for the period 2010-2019. Data included information on gender, age, geographical distribution, site of metastasis, and histology types.RESULTS:A total of 9,593 cases of CUP were registered …

Dynamic Contrast Enhanced Magnetic Resonance Imaging In Pathological Nipple Discharge, Balsam Balasim, Sahar Ahmed

Iraqi Postgraduate Medical Journal

BACKGROUND: Generally, nipple discharge represents a benign etiology. In the case where the discharge is unilateral, uniductal, spontaneous, persistent, serous or bloody, and in the case where it occurs in conjunction with a mass, the risk of malignancy is increased. Ductal ectasia and papilloma are the most common causes of pathological nipple discharges. Malignancy is a possibility, most often ductal carcinoma in situ.OBJECTIVE: To determine the value regarding dynamic contrast improved magnetic resonance imaging (MRI) in diagnosing suspicious nipple discharge.METHOD AND PATIENTS:Dynamic contrast MRI was used to assess 35 patients who have pathological nipple discharges.                    The features of MRI have …

Underwater Image Translation Via Multi-Scale Generative Adversarial Network, Dongmei Yang, Tianzi Zhang, Boquan Li, Menghao Li, Weijing Chen, Xiaoqing Li, Xingmei Wang

Research Collection School Of Computing and Information Systems

The role that underwater image translation plays assists in generating rare images for marine applications. However, such translation tasks are still challenging due to data lacking, insufficient feature extraction ability, and the loss of content details. To address these issues, we propose a novel multi-scale image translation model based on style-independent discriminators and attention modules (SID-AM-MSITM), which learns the mapping relationship between two unpaired images for translation. We introduce Convolution Block Attention Modules (CBAM) to the generators and discriminators of SID-AM-MSITM to improve its feature extraction ability. Moreover, we construct style-independent discriminators that enable the discriminant results of SID-AM-MSITM to …

The Himalayan Uplift And Evolution Of Aquatic Biodiversity Across Asia: Snowtrout (Cyprininae: Schizothorax) As A Test Case, Binod Regmi, Marlis R. Douglas, Karma Wangchuk, Zachery D. Zbinden, David R. Edds, Singye Tshering, Michael E. Douglas

Biological Sciences Faculty Publications and Presentations

Global biodiversity hotspots are often remote, tectonically active areas undergoing climatic fluctuations, such as the Himalaya Mountains and neighboring Qinghai-Tibetan Plateau (QTP). They provide biogeographic templates upon which endemic biodiversity can be mapped to infer diversification scenarios. Yet, this process can be somewhat opaque for the Himalaya, given substantial data gaps separating eastern and western regions. To help clarify, we evaluated phylogeographic and phylogenetic hypotheses for a widespread fish (Snowtrout: Cyprininae; Schizothorax) by sequencing 1,140 base pair of mtDNA cytochrome-b (cytb) from Central Himalaya samples (Nepal: N = 53; Bhutan: N = 19), augmented with 68 GenBank …

Predicting Stringent Quantiferon-Tb Gold Plus Conversions In Contacts Of Tuberculosis Patients, Sheng-Wei Pan, Donald G. Catanzaro, Marva Seifert, Rehan Syed, Naomi Hillery, Mei-Lin Ho, Valeriu Crudu, Elena Tudor, Nelly Ciobanu, Alexandru Codreanu, Antonino Catanzaro, Timonthy C. Rodwell

Biological Sciences Faculty Publications and Presentations

Objectives

Methods

Results

Striving To Increase Bipoc Family Participation In Early Childhood Family Education, Ayuko Boomer

School of Education and Leadership Student Capstone Theses and Dissertations

Boomer, A. U. (2023). Striving to Increase BIPOC Family Participation in Early Childhood Family Education. Early Childhood Family Education (ECFE) is a public education program designed and available for all parents and families in Minnesota. Despite these intentions, many Black, Indigenous, and People of Color (BIPOC) families remain unaware of ECFE's existence and its significance. The purpose of this study is to understand the current methodologies of parent education outreach and collaboration with other programs, in particular, BIPOC communities, and explore and process what efforts have been made to increase BIPOC participation in traditional ECFE parent education group classes (non-affinity …

Career Influences Of Environmental Education Field Experiences, Lacey Day

School of Education and Leadership Student Capstone Theses and Dissertations

As an environmental educator who got her start exploring the various flora and fauna around me, it has always interested me to know whether the same experiences that got me to where I am today have also influenced others to pursue similar careers. This study, because of that initial interest, set out to determine How do environmental education field experiences influence college major and/or career choice in high school students? Through a 21 question, cross-sectional survey, high school students in Allegany County Public Schools were asked a series of questions pertaining to their environmental educational field experiences, their values and …

Firearm Contagion: A New Look At History, Rachel Martin, Michael R. Ulrich

Fordham Urban Law Journal

No abstract provided.

College Of Natural Sciences Newsletter, September - October 2023, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

Page 1 Dean's Message
Page 2 New Faculty an Staff for the Fall 2023 Semester
Page 3 Awards
Page 4 Student Ambassadors in CNS
Page 5 Meet our Jacks
Page 6-8 Events
Page 9-11 Media Coverage of CNS
Page 12-13 Spring 2023 Dean's List
Page 14 Open PRAIRIE Data

Farnesol Brain Transcriptomics In Cns Inflammatory Demyelination, William J. Doyle, Dana Walters, Xutong Shi, Kristina Hoffman, Krisztian Magori, Jean-Baptiste Roullet, Javier Ochoa-Repáraz

Biology Faculty Publications and Presentations

Background: Farnesol (FOL) prevents the onset of experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS).

Objective: We examined the transcriptomic profile of the brains of EAE mice treated with daily oral FOL using next-generation sequencing (RNA-seq).

Methods: Transcriptomics from whole brains of treated and untreated EAE mice at the peak of EAE was performed.

Results: EAE-induced mice, compared to naïve, healthy mice, overall showed increased expression in pathways for immune response, as well as an increased cytokine signaling pathway, with downregulation of cellular stress proteins. FOL downregulates pro-inflammatory pathways and attenuates the immune response in EAE. FOL …

Urban Disaster Wrought By Man: The Battle For Manila, 1945, Russell W. Glenn

Journal of Strategic Security

Urban warfare tends to be intimate. If soldiers do not see the faces of those they kill—and they frequently will—those men and women will hear the screams or muffled groans of the wounded. US forces waging the battle to recapture Manila in 1945 experienced these horrors. Yet it was the noncombatants who suffered far more; 100,000—approximately one of every ten Manileños at the time—died during the fighting. Thousands more suffered wounds, disease, or struggled with hunger and malnutrition. Recent fighting in Syria, Ukraine, Khartoum, and elsewhere tells us too little has changed three-quarters of a century later.

Though urban warfare …

Emeriti News Fall 2023, Emeriti Council

Emeriti News

• Message from the Chair
• Bio-Sketch of Dawn L. Anderson
• Bio-Sketch of Darryl A. Salisbury
• Bio-Sketch of Barbara U. Hemphill
• Medallion Scholars
• Reminders from the Chair
• Administrative Updates
• News from WMU Emeriti
• In Memoriam

[Dataset] Comparison Of Intermittent Fasting And Voluntary Wheel Running On Physical And Cognitive Abilities In High-Fat Diet-Induced Obese Rats, Chaya Gopalan, Paige Niepoetter, Carolyn Butts-Wilmsmeyer, Sai Medavaka, Avery Ogle, Sheyenne Daughrity, Elizabeth Hackmann, Saruveish Mogan, Oskar Lenz

Applied Health Faculty Research, Scholarship, and Creative Activity

Regular physical activity is a proven routine for weight management in addressing obesity. Another method that has gained attention for its health benefits is intermittent fasting (IF). Physical and cognitive abilities while on these routines are poorly understood in the obese population. Sixty-five male Sprague Dawley rats at 7 weeks of age were subjected to diet-induced obesity by feeding a high-fat diet (HFD) or a standard diet (SD) for 8 weeks, after which behavioral testing was performed to detect any changes in physical and cognitive abilities. Rats from the HFD-fed (now considered obese) and SD-fed groups were then subjected to …

Potent Bile Acid Microbial Metabolites Modulate Clostridium Perfringens Virulence, Tahrir Jatli Alenezi, Ying Fu, Bilal Alrubaye, Thamer Alanazi, Ayidh Almansour, Hong Wang, Xiaolun Sun

Poultry Science Faculty Publications and Presentations

Clostridium perfringens is a versatile pathogen, inducing diseases in the skin, intestine (such as chicken necrotic enteritis (NE)), and other organs. The classical sign of NE is the foul smell gas in the ballooned small intestine. We hypothesized that deoxycholic acid (DCA) reduced NE by inhibiting C. perfringens virulence signaling pathways. To evaluate the hypothesis, C. perfringens strains CP1 and wild-type (WT) HN13 and its mutants were cultured with different bile acids, including DCA and isoallolithocholic acid (isoalloLCA). Growth, hydrogen sulfide (H₂S) production, and virulence gene expression were measured. Notably, isoalloLCA was more potent in reducing growth, H …

Management Of A Failing Implant Using Guided Bone Regeneration And Esthetic Crown Lengthening In The Esthetic Zone; A Case Report, Bassam M. Kinaia Dds, Ms, Dicoi, Mirranda Kinaia Bs, Roksolana Gala Dds, Ms, Ashleigh Turows Dds, Ms, Anthony L. Neely Dds, Mdentsc, Phd

The Journal of the Michigan Dental Association

A 34-year-old female presented with a failing implant in the esthetic zone. The implant was removed, and the site was reconstructed with guided bone regeneration and a pedicle connective tissue graft. Esthetic crown lengthening was performed on the adjacent teeth to create a harmonious gingival symmetry. Full ceramic crowns were placed on all teeth, including an implant-supported fixed partial denture. Follow-ups at 3, 6, and 12 months showed proper healing with healthy soft tissues and correct bilateral gingival symmetry. The pink and white esthetic scores improved from 8.7 pre-operatively to 19.2 post-final restorations. The patient was pleased with the esthetic …

Rapid Approach For Assessing An Unregulated Fishery Using A Series Of Data-Limited Tools, Carissa L. Gervasi, Mandy Karnauskas, Adyan Rios, Rolando O. Santos, W. Ryan James, Ryan J. Rezek, Jennifer S. Rehage

Marine Science

Objective: Fisheries provide countless benefits to human populations but face many threats ranging from climate change to overfishing. Despite these threats and an increase in fishing pressure globally, most stocks remain unassessed and data limited. An abundance of data-limited assessment methods exists, but each has different data requirements, caveats, and limitations. Furthermore, developing informative model priors can be difficult when little is known about the stock, and uncertain model parameters could create misleading results about stock status. Our research illustrates an approach for rapidly creating robust initial assessments of unregulated and data-limited fisheries without the need for additional data collection. …