Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (5301)
- Social and Behavioral Sciences (3170)
- Arts and Humanities (2859)
- Nursing (1813)
- Law (1572)
-
- Education (1566)
- Medical Specialties (1246)
- History (1153)
- Higher Education (909)
- Public Health (840)
- Religion (803)
- Sociology (674)
- Health Law and Policy (599)
- Communication (582)
- Public History (581)
- Business (506)
- Psychology (495)
- Social Work (426)
- Public Affairs, Public Policy and Public Administration (390)
- Health and Medical Administration (379)
- Medical Education (325)
- Life Sciences (308)
- Medical Sciences (290)
- Diseases (289)
- Oncology (272)
- Catholic Studies (266)
- Social History (263)
- Mental and Social Health (261)
- United States History (261)
- Palliative Care (244)
- Institution
-
- Brigham Young University - Hawaii (3893)
- University of New Hampshire (2658)
- Murray State University (1309)
- Sigma Theta Tau International Honor Society of Nursing (730)
- Washington University School of Medicine (605)
-
- Georgia Southern University (582)
- Lehigh Valley Health Network (574)
- University of South Florida (569)
- Walden University (356)
- The Texas Medical Center Library (345)
- Advocate Health - Midwest (313)
- Western Michigan University (297)
- University of Alabama at Birmingham (287)
- Thomas Jefferson University (272)
- University of San Diego (256)
- College of the Holy Cross (238)
- DePaul University (234)
- University of Mississippi (229)
- Nova Southeastern University (227)
- Marquette University (211)
- Grand Valley State University (210)
- Morehead State University (207)
- University of Montana (206)
- University of Kentucky (205)
- University of North Dakota (194)
- Liberty University (185)
- Yale University (183)
- Marshall University (182)
- University of New Mexico (174)
- University of Dayton (170)
- Keyword
-
- Palliative care (422)
- Nursing (347)
- Humans (341)
- Hospice (339)
- Newsletter (296)
-
- African-American newspapers, African Americans (278)
- Palliative Care (223)
- Education (221)
- COVID-19 (191)
- Alumni (190)
- Church work with the deaf -- Catholic Church (188)
- Deaf -- Periodicals (188)
- Deaf culture (188)
- Hearing impaired (188)
- Newspaper (188)
- Pastoral care of people with disabilities (188)
- Female (183)
- Male (172)
- Aged (166)
- Cancer (162)
- Death (159)
- Medicare (150)
- UAB (149)
- Ethics (147)
- Grief (140)
- Dementia (138)
- End-of-life care (137)
- EReporter (132)
- Burnout (129)
- End-of-life (124)
- Publication Year
- Publication
-
- Obituaries (3893)
- The Murray Ledger & Times (1260)
- African American Funeral Programs (443)
- Walden Dissertations and Doctoral Studies (350)
- BJC Today (335)
-
- Weekly Challenger Newspaper Collection (314)
- Dissertations (303)
- Checkup (246)
- Theses and Dissertations (233)
- International Nursing Research Congress (INRC) (200)
- Electronic Theses and Dissertations (186)
- Historical Documents - Combined (184)
- Faculty, Staff and Student Publications (167)
- Biennial Convention (CONV) (144)
- eReporter (campus newsletter) (132)
- Progress Notes (124)
- Doctoral Dissertations and Projects (122)
- Cal Poly Student Newspaper (102)
- Doctor of Nursing Practice Projects (102)
- Morehead News Archive (101)
- Faculty Publications (98)
- Faculty Scholarship (93)
- Masters Theses (88)
- Faculty, Staff and Students Publications (85)
- The Linacre Quarterly (79)
- The New Hampshire Print Edition (77)
- Theses and Graduate Projects (76)
- All ETDs from UAB (74)
- DNP Projects (72)
- Personnel Catalogues (72)
- Publication Type
- File Type
Articles 2941 - 2970 of 28868
Full-Text Articles in Entire DC Network
Applying The Extended Theory Of Planned Behaviour (Tpb) To Predict Behavioural Intention In The Context Of Transformational Tourism: A Case Of Nizamuddin Shrine, Samiha Siddiqui, Sujood ., Sheeba Hamid
Applying The Extended Theory Of Planned Behaviour (Tpb) To Predict Behavioural Intention In The Context Of Transformational Tourism: A Case Of Nizamuddin Shrine, Samiha Siddiqui, Sujood ., Sheeba Hamid
International Journal of Religious Tourism and Pilgrimage
The term ‘transformational tourism’ refers to a burgeoning subset of the travel market that goes well beyond the more established categories of just spiritual and religious tourism. This paper aims at examining tourists’ intentions to visit the Nizamuddin Shrine (Delhi) as a transformational tourism destination. The framework incorporates the constructs of the Theory of Planned Behaviour (TPB) i.e. Attitude, Subjective Norms, and Perceived Behavioural Control with an additional construct, Motivation. A Google forms online survey was employed to gather data. Structural Equation Modelling (SEM) using AMOS software was employed to test the proposed hypotheses. A sample of 388 respondents was …
Home And Community-Based Service Utilization Patterns For Seniors With Alzheimer's Disease And Related Dementias, Margaret E. Saari
Home And Community-Based Service Utilization Patterns For Seniors With Alzheimer's Disease And Related Dementias, Margaret E. Saari
Dissertations
Half a million Canadians are living with Alzheimer's disease and related dementias. Approximately half these individuals live in the community, supported by informal caregivers. In this population, utilization of formal services is low and patterns of utilization are not well understood. Previous studies examining predictors of service use have examined services in isolation however, often multiple services are utilized, with little coordination between services.
The purpose of this study was to provide a better understanding of the community-based services utilized concurrently by seniors with dementia and their caregivers.
The Spiritual Migrants Of Sogenji: Notes Of Participant Observation In A Rinzai Zen Temple, Andrei-Razvan Coltea
The Spiritual Migrants Of Sogenji: Notes Of Participant Observation In A Rinzai Zen Temple, Andrei-Razvan Coltea
International Journal of Religious Tourism and Pilgrimage
Anomie is a cultural pathology that is becoming chronic in the West, characterized by the erosion of values, disintegration and deregulation. Amongst its symptoms we find anxiety, isolation, depression, tribalism, incoherence and loss of meaning. Individuo-globalism is a new ideology that permeates the religious market created by globalisation, encouraging individuals to discover, nurture and express their ‘true self’. This new spirituality forms the background for a journey that our ‘heroes’, a handful of non-Japanese inhabitants of a Japanese Rinzai Zen monastery, have been undertaking for years in search of the philosopher’s stone that could cure anomie and its symptoms. At …
Augustana Hospital School Of Nursing Yearbook, 1927, Advocate Aurora Health
Augustana Hospital School Of Nursing Yearbook, 1927, Advocate Aurora Health
Historical Documents - Combined
Augustana Hospital School of Nursing, Chicago, IL: The 'Our Book 1927 Yearbook.
The Weekly Challenger, June 8, 2023, The Weekly Challenger, Et Al
The Weekly Challenger, June 8, 2023, The Weekly Challenger, Et Al
Weekly Challenger Newspaper Collection
The June 8, 2023, issue of The Weekly Challenger.
Feeling The Burn: A Phenomenological Study On Burnout Among Adjunct Professors At Higher Education Institutions, Janette B. Whitmore
Feeling The Burn: A Phenomenological Study On Burnout Among Adjunct Professors At Higher Education Institutions, Janette B. Whitmore
Doctoral Dissertations and Projects
The purpose of this transcendental phenomenological study was to understand the lived experiences of burnout among adjunct professors at higher education institutions. The central research question guiding this study was what are the lived experiences of burnout among adjunct professors at higher education institutions? This study found that adjunct professors burned-out due to their higher education institutions’ unreasonable work expectations, tight deadlines, and lack of resources. Using the guiding theory of job demands and resources (JD-R) developed by Demerouti, Bakker, Nachreiner, and Schaufeli, the phenomenon’s essence was discovered as it highlighted how excessive work demands and a lack of resources …
A Good Death: Personal Autonomy And Medical Decision Making In Louisiana, Elizabeth Carter
A Good Death: Personal Autonomy And Medical Decision Making In Louisiana, Elizabeth Carter
Louisiana Law Review
No abstract provided.
Hyperthermic Extracorporeal Applied Tumor Therapy (Heatt®) In Advanced Unresponsive Cancer, Joseph B. Zwischenberger, Peyton Skaggs, Katherine Breetz, Jan Winetz, Roger Vertrees
Hyperthermic Extracorporeal Applied Tumor Therapy (Heatt®) In Advanced Unresponsive Cancer, Joseph B. Zwischenberger, Peyton Skaggs, Katherine Breetz, Jan Winetz, Roger Vertrees
Journal of Shock and Hemodynamics
Hyperthermia has been utilized for cancer therapy, including metastatic cancer, for decades with isolated success. Previous research has indicated that the elevated temperature of 42°C induces cell death, apoptosis, or senescence of responsive cancers, providing a mechanism for tumor destruction and management. Veno-venous perfusion-induced systemic hyperthermia (V-V PISH) may be the key to improving advanced tumor responsiveness to previously failed chemotherapy and/or radiation as combination therapy. The most recent iteration of V-V PISH, Hyperthermic Extracorporeal Applied Tumor Therapy (HEATT®), provides homogeneous heating of all tissues with electrolyte and pH control and continues to prove safe and effective. The utilization of …
Lutheran General Hospital: An Institution Intent On A Moral Purpose, 1980, Advocate Aurora Health
Lutheran General Hospital: An Institution Intent On A Moral Purpose, 1980, Advocate Aurora Health
Historical Documents - Combined
Lutheran General Hospital, Park Ridge, IL: This report, compiled in 1980, is about LGH Memory, Challenges, and Prospects. It is part of a consultative service provided by Dr. Kenneth Vaux to the formative project at Lutheran General Hospital entitled “Human Values Forum.” The report deals with vital issues, set against a background of the values which informed the founders of LGH and culminating in guidelines for future directions when confronting these issues.
End-Of-Life Care In The Trauma Bay: Six Key Points, Louis Christie Dr
End-Of-Life Care In The Trauma Bay: Six Key Points, Louis Christie Dr
Journal of Geriatric Emergency Medicine
The dominant culture across North America, Europe and Australia has been characterized by workers in hospice and palliative care as ‘death denying’ or ‘death phobic’. The last two decades have seen a significant increase in the number of trauma patients with complex background co-morbidities due to advanced age. Effective end-of-life care in trauma requires physicians to begin careful, balanced and sensitive conversations encompassing goals of care and expectation-setting, in the trauma bay. These pointers will help the reader communicate the principles of these clinical decisions clearly to patients and their families.
Cuando Lloro, Melissa Medina
Cuando Lloro, Melissa Medina
Masters Theses
There are moments where I am suddenly hit with a deep sentimental longing for a time that no longer exists, one that has transformed into a deep nostalgia, one that becomes more and more conflicted as time passes. Often thought of as a yearning for a recent past, or homesickness, nostalgia can be difficult to define. Although the concept and emotion associated with nostalgia may seem familiar, the word is in fact complex. Nostalgia, for the immigrant, is an escape from their marginalization; an opportunity to embrace the complexities. Painting then becomes an embrace, a direct connection between the present …
Paperwork, Paradox, And Prn: Psychotropic Medication Deficiencies In Assisted Living, Sarah Dys, Paula Carder
Paperwork, Paradox, And Prn: Psychotropic Medication Deficiencies In Assisted Living, Sarah Dys, Paula Carder
Institute on Aging Publications
Individual state approaches to assisted living/residential care (AL/RC) licensing and oversight in the United States result in different practice standards and requirements, including psychotropic medication use. We examined 170 psychotropic medication deficiency citations issued to 152 Oregon AL/RC settings from 2015 to 2019. Applied thematic analysis resulted in the following themes: (1) documentation issues are primarily responsible for noncompliance, (2) unclear parameters place direct care workers in a role paradox, and (3) there is a persistent disconnect about when to seek qualified expertise before requesting psychotropic medications. AL/RC-specific mechanisms for medication prescription and administration are necessary to improve the structure …
Fire And Life Safety Evaluation Of An Assisted Living And Memory Care Center, Sarah Chandonait
Fire And Life Safety Evaluation Of An Assisted Living And Memory Care Center, Sarah Chandonait
Fire Protection Engineering: Culminating Experience Project Reports
This culminating project has been submitted as part of the graduate program in Fire Protection Engineering at Cal Poly. It documents an Assisted Living and Memory Care Center’s compliance with applicable fire safety prescriptions contained in the 2019 California Building and Fire Codes (CBC and CFC). Performance-based methods incorporating deterministic design fires were then used to verify that the final building design and operating procedures met the life safety needs of its unique occupants.
The building under analysis was a 45,000 sq. ft, two-story, 58-bed residential care facility for the elderly. Occupants were all 60 years or older without acute …
Investigating The Impact Of The 2022 Iv Contrast Shortage On Imaging Utilization And Patient Outcomes At Lvhn: A Quality Improvement Study, Henry Slone, Matthew Mccambridge Md, Devang Gor Md, Mba, Michele Hartzell
Investigating The Impact Of The 2022 Iv Contrast Shortage On Imaging Utilization And Patient Outcomes At Lvhn: A Quality Improvement Study, Henry Slone, Matthew Mccambridge Md, Devang Gor Md, Mba, Michele Hartzell
USF-LVHN SELECT
No abstract provided.
Evaluation Of Otolaryngologic And Neurosurgical Intervention In Lvhn Patients Diagnosed With Temporal Bone Fractures, Albert Chen, Christopher Wang, Robert M. Dedio Md
Evaluation Of Otolaryngologic And Neurosurgical Intervention In Lvhn Patients Diagnosed With Temporal Bone Fractures, Albert Chen, Christopher Wang, Robert M. Dedio Md
USF-LVHN SELECT
No abstract provided.
Uni Political Science Newsletter, V18, 2022-23, University Of Northern Iowa. Department Of Political Science.
Uni Political Science Newsletter, V18, 2022-23, University Of Northern Iowa. Department Of Political Science.
Political Science Newsletter
Contents:
Making Democracy Work --- 1
Vajpeyi Fellowship --- 3
Undergraduate Research --- 3
Women in Politics Scholarship Event --- 4
Civic Education --- 5
Panthers Vote --- 6
Model United Nations --- 6
You're Next --- 7
Faculty Updates --- 9
Congratulations 2022-23 Graduates --- 11
Graduate Profiles --- 12
Pi Sigma Alpha Inductees --- 13
Awards & Honors --- 13
Spirituality Education For End Of Life Clinicians: A Quality Improvement Project, Mark S. Valigorsky
Spirituality Education For End Of Life Clinicians: A Quality Improvement Project, Mark S. Valigorsky
DNP Projects
Significance and Background: The focus of this project was to strength the knowledge, comfort, and training of end of life(EOL) clinicians working with patients in the palliative care and hospice environments. While spirituality is considered one of the essential domains of hospice care, it is an area that is often brushed aside by staff and patients and their families. Spirituality is inadequately addressed due to knowledge deficits, time issues, and lack of self-efficacy. Addressing spiritual care is particularly important for patients with chronic and end stage illnesses. Patients and their families view spirituality as a way of coping with suffering. …
The Time Has Come: A Proposal For New York To Legalize Physician-Assisted Death, Samantha Knice
The Time Has Come: A Proposal For New York To Legalize Physician-Assisted Death, Samantha Knice
Hofstra Law Review
The article focuses on the proposal that advocate for the legalization of physician-assisted death (PAD) in New York. It begins by highlighting the story of Charlie and Francie Emerick, a terminally ill couple who chose to use Oregon's Death with Dignity Act to peacefully end their lives. It further argues that New York should follow the example of other states and countries by enacting a PAD law.
Mini-Mental State Examination (Mmse) As Predictor Of On-Road Driving Ability, Erica Bailey Floyd, Katelyn Elizabeth Stewart, Elizabeth Claire Morris, Hayes Elizabeth Franklin, Kristin Elizabeth Mather, Caymen Lynn Starwalt
Mini-Mental State Examination (Mmse) As Predictor Of On-Road Driving Ability, Erica Bailey Floyd, Katelyn Elizabeth Stewart, Elizabeth Claire Morris, Hayes Elizabeth Franklin, Kristin Elizabeth Mather, Caymen Lynn Starwalt
Master of Occupational Therapy Student Critically Appraised Topics
Students met with a community OT practitioner who specializes in driving rehabilitation. The community practitioner identified a potential gap in referrals for individuals with cognitive impairment and on-road driving assessments. Due to the scarcity of driving rehabilitation practitioners, it is important to provide effective evaluation and interview. By identifying clients who are past the potential for safe on-road driving performance due to their score on a status examination, practitioners can reach more clients in a more efficacious manner. There exists a need for a more accurate screening measure to predict on road driving performance in individuals with cognitive impairment. The …
Physician Aid In Dying: Physician-Assisted Suicide As A Constitutionally Protected Liberty Interest Under The Nebraska Constitution, Emily Newcomb
Physician Aid In Dying: Physician-Assisted Suicide As A Constitutionally Protected Liberty Interest Under The Nebraska Constitution, Emily Newcomb
Nebraska Law Review
“Every life is different from any that has gone before it, and so is every death.”1 Although advancements in technology and healthcare have saved and prolonged countless lives, there is one part of humanity that can never be fully cured: death. Death is not what it used to be—it is no longer normally a common, family communal, or even religious event.2 Modern dying takes place in a hospital while attached to machines that attempt to prolong life but seem to simultaneously take patients further and further away from dying with dignity. As these technologies that prolong life evolve, so do …
Ministry Through Covid And Beyond
Ministry Through Covid And Beyond
Journal of Adventist Youth and Young Adult Ministries
No abstract provided.
The Impact Of A Virus: A High Level View, Steve Case
The Impact Of A Virus: A High Level View, Steve Case
Journal of Adventist Youth and Young Adult Ministries
No abstract provided.
"I Stayed There The Whole Night": Exploring Caregivers' Experiences With The Healthcare System When Caring For A Parent At The End Of Life, Lillian Mehran
"I Stayed There The Whole Night": Exploring Caregivers' Experiences With The Healthcare System When Caring For A Parent At The End Of Life, Lillian Mehran
Dissertations and Theses
Background: In the United States, there are nearly 53 million individuals serving as caregivers to a loved one. Half of all caregivers are caring for a parent or parent-in-law, and 79% of caregivers are caring for a person aged 50 or older. In New York State, there are an estimated 4.1 million caregivers who collectively provide over 2.6 billion hours of unpaid care, with those caring for a person at the end of life providing twice as many hours of caregiving per week compared to other caregivers. The number of individuals requiring caregiving is expected to increase as a significant …
Community Paramedicine In Central Oregon: A Promising Model To Reduce Non-Urgent Emergency Department Utilization Among Medically Complexmedicaid Beneficiaries, Jessica Currier, Neal Wallace, Keshia Bigler, Maggie O’Connor, Paige E. Farris, Jackilen Shannon
Community Paramedicine In Central Oregon: A Promising Model To Reduce Non-Urgent Emergency Department Utilization Among Medically Complexmedicaid Beneficiaries, Jessica Currier, Neal Wallace, Keshia Bigler, Maggie O’Connor, Paige E. Farris, Jackilen Shannon
OHSU-PSU School of Public Health Faculty Publications and Presentations
Background
Community paramedicine has emerged as a promising model to redirect persons with nonmedically emergent conditions to more appropriate and less expensive community-based health care settings. Outreach through community paramedicine to patients with a history of high hospital emergency department (ED) use and chronic health conditions has been found to reduce ED use. This study examined the effect of community paramedicine implemented in 2 rural counties in reducing nonemergent ED use among a sample of Medicaid beneficiaries with complex medical conditions and a history of high ED utilization.
Methods
A cluster randomized trial approach with a stepped wedge design was …
Real-World Safety Of Neurohormonal Antagonist Initiation Among Older Adults Following A Heart Failure Hospitalization, Parag Goyal, Andrew R Zullo, Barbara Gladders, Chukwuma Onyebeke, Min Ji Kwak, Larry A Allen, Emily B Levitan, Monika M Safford, Lauren Gilstrap
Real-World Safety Of Neurohormonal Antagonist Initiation Among Older Adults Following A Heart Failure Hospitalization, Parag Goyal, Andrew R Zullo, Barbara Gladders, Chukwuma Onyebeke, Min Ji Kwak, Larry A Allen, Emily B Levitan, Monika M Safford, Lauren Gilstrap
Faculty, Staff and Student Publications
AIMS: To optimize guideline-directed medical therapy for heart failure, patients may require the initiation of multiple neurohormonal antagonists (NHAs) during and following hospitalization. The safety of this approach for older adults is not well established.
METHODS AND RESULTS: We conducted an observational cohort study of 207 223 Medicare beneficiaries discharged home following a hospitalization for heart failure with reduced ejection fraction (HFrEF) (2008-2015). We performed Cox proportional hazards regression to examine the association between the count of NHAs initiated within 90 days of hospital discharge (as a time-varying exposure) and all-cause mortality, all-cause rehospitalization, and fall-related adverse events over the …
Differential Effects Of An Ed-To-Home Care Transitions Intervention In An Older Adult Population: A Latent Class Analysis, Rebecca K Green, Kenneth J Nieser, Gwen C Jacobsohn, Amy L Cochran, Thomas V Caprio, Jeremy T Cushman, Amy J H Kind, Michael Lohmeier, Manish N Shah
Differential Effects Of An Ed-To-Home Care Transitions Intervention In An Older Adult Population: A Latent Class Analysis, Rebecca K Green, Kenneth J Nieser, Gwen C Jacobsohn, Amy L Cochran, Thomas V Caprio, Jeremy T Cushman, Amy J H Kind, Michael Lohmeier, Manish N Shah
Faculty, Staff and Student Publications
BACKGROUND: Older adults frequently return to the emergency department (ED) within 30 days of a visit. High-risk patients can differentially benefit from transitional care interventions. Latent class analysis (LCA) is a model-based method used to segment the population and test intervention effects by subgroup.
OBJECTIVES: We aimed to identify latent classes within an older adult population from a randomized controlled trial evaluating the effectiveness of an ED-to-home transitional care program and test whether class membership modified the intervention effect.
RESEARCH DESIGN: Participants were randomized to receive the Care Transitions Intervention or usual care. Study staff collected outcomes data through medical …
Divergent Clinical Presentations And Outcomes Among Children And Adolescents With Kaposi Sarcoma In Malawi And Tanzania, Liane R Campbell, Allison Silverstein, Erin Peckham-Gregory, William Kamiyango, Jimmy Villiera, Casey L Mcatee, Jason M Bacha, Carrie L Kovarik, Parth S Mehta, Toni Chanroo, Asulwisye Kapesa, Beatrice Malingoti, Rizine Mzikamanda, Nmazuo W Ozuah, Carl E Allen, Michael E Scheurer, Nader K El-Mallawany
Divergent Clinical Presentations And Outcomes Among Children And Adolescents With Kaposi Sarcoma In Malawi And Tanzania, Liane R Campbell, Allison Silverstein, Erin Peckham-Gregory, William Kamiyango, Jimmy Villiera, Casey L Mcatee, Jason M Bacha, Carrie L Kovarik, Parth S Mehta, Toni Chanroo, Asulwisye Kapesa, Beatrice Malingoti, Rizine Mzikamanda, Nmazuo W Ozuah, Carl E Allen, Michael E Scheurer, Nader K El-Mallawany
Center for Medical Ethics and Health Policy Staff Publications
Objectives: The Kaposi sarcoma (KS) T0 versus T1 staging classification does not address the unique clinical features of paediatric KS in human gammaherpesvirus 8 (HHV-8) endemic regions of Africa. This study seeks to define patterns of childhood KS using a paediatric-specific approach.
Methods: The Lilongwe paediatric KS staging classification categorizes disease based on clinical phenotype: stage 1 = mild/moderate KS limited to cutaneous/oral involvement, stage 2 = primarily lymphadenopathic disease, stage 3 = woody edema KS, stage 4 = visceral and/or severe/disseminated mucocutaneous disease. Characteristics and outcomes were evaluated from paediatric referral centres in Lilongwe, Malawi, and Mbeya, Tanzania.
Results: …
Integration Of Remote Symptom And Biometric Monitoring Into The Care Of Adult Patients With Cancer Receiving Chemotherapy-A Decentralized Feasibility Pilot Study, Anaeze C Offodile, Domenica Delgado, Yu-Li Lin, Danielle Geyen, Christopher J Miller, Sanchita Jain, Janice P Finder, Sanjay Shete, Frank V Fossella, Michael J Overman, Susan K Peterson
Integration Of Remote Symptom And Biometric Monitoring Into The Care Of Adult Patients With Cancer Receiving Chemotherapy-A Decentralized Feasibility Pilot Study, Anaeze C Offodile, Domenica Delgado, Yu-Li Lin, Danielle Geyen, Christopher J Miller, Sanchita Jain, Janice P Finder, Sanjay Shete, Frank V Fossella, Michael J Overman, Susan K Peterson
Faculty, Staff and Student Publications
PURPOSE: Although electronic patient-reported outcomes (ePROs) are efficacious in symptom management, much is unknown about the utility of vital signs surveillance. We examined the feasibility of a remote patient monitoring platform that integrates ePROs and biometrics into the ambulatory management of symptom burden.
METHODS: Using a decentralized workflow, patients with gastrointestinal or thoracic cancer were approached for a 1-month study. Patients reported symptom burden via ePROs and biometrics (blood pressure, oxygen saturation, pulse, weight, and temperature) using bluetooth-enabled devices daily. Alerts on the basis of prespecified thresholds were managed via nurse-led triage. Adherence was defined as the completion of > 70% …
Ovarian Cancer Pathology Characteristics As Predictors Of Variant Pathogenicity In Brca1 And Brca2, Denise G O'Mahony, Susan J Ramus, Melissa C Southey, Nicola S Meagher, Andreas Hadjisavvas, Esther M John, Ute Hamann, Evgeny N Imyanitov, Irene L Andrulis, Priyanka Sharma, Mary B Daly, Christopher R Hake, Jeffrey N Weitzel, Anna Jakubowska, Andrew K Godwin, Adalgeir Arason, Anita Bane, Jacques Simard, Penny Soucy, Maria A Caligo, Phuong L Mai, Kathleen B M Claes, Manuel R Teixeira, Wendy K Chung, Conxi Lazaro, Peter J Hulick, Amanda E Toland, Inge Sokilde Pedersen, Susan L Neuhausen, Ana Vega, Miguel De La Hoya, Heli Nevanlinna, Mallika Dhawan, Valentina Zampiga, Rita Danesi, Liliana Varesco, Viviana Gismondi, Valerio Gaetano Vellone, Paul A James, Ramunas Janavicius, Liene Nikitina-Zake, Finn Cilius Nielsen, Thomas Van Overeem Hansen, Tanja Pejovic, Ake Borg, Johanna Rantala, Kenneth Offit, Marco Montagna, Katherine L Nathanson, Susan M Domchek, Ana Osorio, María J García, Beth Y Karlan, Gemo Study Collaborators, Anna De Fazio, David Bowtell, Aocs Group, Lesley Mcguffog, Michael T Parsons, Thilo Dörk, Lisa-Marie Speith, Elizabeth Santana Dos Santos, Alexandre André B A Da Costa, Paolo Radice, Paolo Peterlongo, Laura Papi, Christoph Engel, Eric Hahnen, Rita K Schmutzler, Barbara Wappenschmidt, Douglas F Easton, Marc Tischkowitz, Christian F Singer, Yen Yen Tan, Alice S Whittemore, Weiva Sieh, James D Brenton, Drakoulis Yannoukakos, Florentia Fostira, Irene Konstantopoulou, Jana Soukupova, Michal Vocka, Czecanca Consortium, Georgia Chenevix-Trench, Paul D P Pharoah, Antonis C Antoniou, David E Goldgar, Amanda B Spurdle, Kyriaki Michailidou, Consortium Of Investigators Of Modifiers Of Brca1/2, Evidence-Based Network For The Interpretation Of Germline Mutant Alleles Consortium, Hebon Investigators, Goska Leslie
Ovarian Cancer Pathology Characteristics As Predictors Of Variant Pathogenicity In Brca1 And Brca2, Denise G O'Mahony, Susan J Ramus, Melissa C Southey, Nicola S Meagher, Andreas Hadjisavvas, Esther M John, Ute Hamann, Evgeny N Imyanitov, Irene L Andrulis, Priyanka Sharma, Mary B Daly, Christopher R Hake, Jeffrey N Weitzel, Anna Jakubowska, Andrew K Godwin, Adalgeir Arason, Anita Bane, Jacques Simard, Penny Soucy, Maria A Caligo, Phuong L Mai, Kathleen B M Claes, Manuel R Teixeira, Wendy K Chung, Conxi Lazaro, Peter J Hulick, Amanda E Toland, Inge Sokilde Pedersen, Susan L Neuhausen, Ana Vega, Miguel De La Hoya, Heli Nevanlinna, Mallika Dhawan, Valentina Zampiga, Rita Danesi, Liliana Varesco, Viviana Gismondi, Valerio Gaetano Vellone, Paul A James, Ramunas Janavicius, Liene Nikitina-Zake, Finn Cilius Nielsen, Thomas Van Overeem Hansen, Tanja Pejovic, Ake Borg, Johanna Rantala, Kenneth Offit, Marco Montagna, Katherine L Nathanson, Susan M Domchek, Ana Osorio, María J García, Beth Y Karlan, Gemo Study Collaborators, Anna De Fazio, David Bowtell, Aocs Group, Lesley Mcguffog, Michael T Parsons, Thilo Dörk, Lisa-Marie Speith, Elizabeth Santana Dos Santos, Alexandre André B A Da Costa, Paolo Radice, Paolo Peterlongo, Laura Papi, Christoph Engel, Eric Hahnen, Rita K Schmutzler, Barbara Wappenschmidt, Douglas F Easton, Marc Tischkowitz, Christian F Singer, Yen Yen Tan, Alice S Whittemore, Weiva Sieh, James D Brenton, Drakoulis Yannoukakos, Florentia Fostira, Irene Konstantopoulou, Jana Soukupova, Michal Vocka, Czecanca Consortium, Georgia Chenevix-Trench, Paul D P Pharoah, Antonis C Antoniou, David E Goldgar, Amanda B Spurdle, Kyriaki Michailidou, Consortium Of Investigators Of Modifiers Of Brca1/2, Evidence-Based Network For The Interpretation Of Germline Mutant Alleles Consortium, Hebon Investigators, Goska Leslie
Faculty, Staff and Student Publications
BACKGROUND: The distribution of ovarian tumour characteristics differs between germline BRCA1 and BRCA2 pathogenic variant carriers and non-carriers. In this study, we assessed the utility of ovarian tumour characteristics as predictors of BRCA1 and BRCA2 variant pathogenicity, for application using the American College of Medical Genetics and the Association for Molecular Pathology (ACMG/AMP) variant classification system.
METHODS: Data for 10,373 ovarian cancer cases, including carriers and non-carriers of BRCA1 or BRCA2 pathogenic variants, were collected from unpublished international cohorts and consortia and published studies. Likelihood ratios (LR) were calculated for the association of ovarian cancer histology and other characteristics, with …
Phase I/Ii Sequencing Study Of Azacitidine, Epacadostat, And Pembrolizumab In Advanced Solid Tumors, Jason J Luke, Marwan Fakih, Charles Schneider, E Gabriela Chiorean, Johanna Bendell, Rebecca Kristeleit, Razelle Kurzrock, Sarah P Blagden, Irene Brana, Laura W Goff, Kevin O'Hayer, Ryan Geschwindt, Michael Smith, Feng Zhou, Aung Naing
Phase I/Ii Sequencing Study Of Azacitidine, Epacadostat, And Pembrolizumab In Advanced Solid Tumors, Jason J Luke, Marwan Fakih, Charles Schneider, E Gabriela Chiorean, Johanna Bendell, Rebecca Kristeleit, Razelle Kurzrock, Sarah P Blagden, Irene Brana, Laura W Goff, Kevin O'Hayer, Ryan Geschwindt, Michael Smith, Feng Zhou, Aung Naing
Faculty, Staff and Student Publications
Background: Indoleamine 2,3-dioxygenase 1 (IDO1), an interferon-inducible enzyme, contributes to tumor immune intolerance. Immune checkpoint inhibition may increase interferon levels; combining IDO1 inhibition with immune checkpoint blockade represents an attractive strategy. Epigenetic agents trigger interferon responses and may serve as an immunotherapy priming method. We evaluated whether epigenetic therapy plus IDO1 inhibition and immune checkpoint blockade confers clinical benefit to patients with advanced solid tumors.
Methods: ECHO-206 was a Phase I/II study where treatment-experienced patients with advanced solid tumors (N = 70) received azacitidine plus an immunotherapy doublet (epacadostat [IDO1 inhibitor] and pembrolizumab). Sequencing of treatment was also assessed. Primary …