Digital Commons Network^™

Finding Novel Therapeutics For Blood Cancer Chemotherapy And Immunotherapy, Jin Li

Doctoral Dissertations

This thesis focuses on identification and development of novel small molecule therapeutics for blood cancer. The studies presented herein examine two classes of novel compounds with different mechanisms: tropolones as chemotherapies (Chapters II and III) and phosphoantigens as immunotherapies (Chapters IV-VII).

A library of α-tropolone derivatives was tested for anti-proliferative effects on a panel of hematological malignancies demonstrating preference towards cells of T cell lineage. Through investigating different compounds, some structure activity relationships for compound potency were determined. As a class, the mechanism of action was reliant upon the caspase pathway, p53 regulation, Akt, mTor, and iron. The α-substituted tropolones …

Search, The Jackson Laboratory

Search Magazine

No abstract provided.

Healthcare, The Environment And Biomedicine, Ahkar Phyo Phyo, Suraj Bala, Mason Barrett, Jack Connelly, Lucy Cummins, Claire Fuller, Hannah Gorga, Jonathan Huang, Dowha Karar, Katrina Kuhn, Elizabeth Lopez-Lopez, Carolina Montoya, Liz Narwold, Lindsay Pett, Shruti Police, Grace Ann Robertson, Rachel Schuman, Virginia Sun, Katie Wall, Ivy Zhong

SSIR Presentations 2019

The final SSIR project aim: To better understand the factors that impact student well-being at the University of Richmond, with a focus on those that raise happiness and reduce stress.

Goals and questions included:

● To find statistically significant data that correlates to who the happiest spidURs are
● Tried to separate student groups to identify individual factors
● Sought out students who had lowest stress, highest happiness

Conserving A Vision: Acadia, Katahdin, And The Pathway From Private Lands To Park Lands, Sean Flaherty, Anthony L. Moffa

Maine Law Review

Although a century separates the official designations, the strategies required to ensure federal protection of Maine’s two National Park Service areas—Acadia National Park and Katahdin Woods and Waters National Monument—closely track one another. In both cases, a handful of enterprising conservationists shared the vision for conservation. Both areas depended on the private acquisition, and donation, of title to the numerous parcels that comprised them before the land could garner federal protection. Politics in the early 20th and 21st centuries had to be overcome. This work tells the stories in parallel, highlighting and analyzing four strands of similarity to not only …

Colby College Catalogue 2019-2020, Colby College

Colby Catalogues

No abstract provided.

Quantification Of Aqp11 Paralog Expression In The Osmoregulatory Organs Of Anguilla Rostrata, Keith C. Kurt

College of Graduate Studies: Theses & Dissertations

Osmoregulation is facilitated by using an assortment of ion and water channels to assist acclimation to changing conditions and to maintain cellular homeostasis. Euryhaline fish can be found in both seawater and freshwater (SW and FW) environments. Expression of ion and water channels have been experimentally demonstrated to change as a fish acclimates to different environmental conditions. Relatively recently, a new group of water channels has been discovered that are primarily intracellular and includes aquaporin 11 (AQP11). Typically, AQPs are located on the cell plasma membrane to allow water to flow in and out of the cell by osmosis to …

The Torch (December 2018), Crtp

Torch: The Civil Rights Team Project Newsletter

Description

Civic and Community Engagement | Civil Rights and Discrimination | Education | Gender and Sexuality | Inequality and Stratification | Politics and Social Change | Public Policy | Race and Ethnicity

Recommended Citation

Baldwin, Brandon and Civil Rights Team Project, "Torch (August 2013)" (2013). Torch: The Civil Rights Team Project Newsletter. 58. http://digitalcommons.usm.maine.edu/torch/58

Mentorship In Medicine And Nephrology: More Important Than Ever, Belinda Jim, Jerry Yee

Nephrology Articles

Mentorship has always been important in medicine. In fact, one can argue that that is how doctors are trained. Moreover, mentorship has been proven to preserve and elevate those who wish to pursue academic medicine. In nephrology, mentorship has become paramount, as interest in the field has declined during this decade. In this article, we will delineate how mentorship impacts physician careers, describe different types of mentors and their characteristics, and summarize responsibilities of mentors and mentees. We will discuss specific challenges in nephrology and the steps that have been taken to address them via mentorship. We conclude that mentorship …

Quillen Magazine - Summer 2018, Quillen College Of Medicine, East Tennessee State University

Quillen Magazine

No abstract provided.

Experimental Evidence That The Non-Native European Fire Ant Alters Invertebrate Communities, Madeson C. Goodman

Biology Theses

Successful non-native species can reduce native species richness through both direct and indirect competition. Many invasive ants, such as the European fire ant (Myrmica rubra), are particularly successful invaders due to their ability to form multi-nest, multi-queen “supercolonies” that appear to displace native ant and non-ant invertebrate fauna in invaded regions. Myrmica rubra has invaded the Northeastern United States, including Tifft Nature Preserve in Western New York, but its seemingly negative impacts on local invertebrate communities have only been assessed using correlative studies, making it difficult to determine whether these ants directly displace native ants and invertebrates or …

Search, The Jackson Laboratory

Search Magazine

No abstract provided.

Full Autumn 2009 Issue, The U.S. Naval War College

Naval War College Review

No abstract provided.

Early Limb Patterning In The Direct‐Developing Salamander Plethodon Cinereus Revealed By Sox9 And Col2a1, Ryan R. Kerney, James Hanken, David C. Blackburn

Biology Faculty Publications

Direct‐developing amphibians form limbs during early embryonic stages, as opposed to the later, often postembryonic limb formation of metamorphosing species. Limb patterning is dramatically altered in direct‐developing frogs, but little attention has been given to direct‐developing salamanders. We use expression patterns of two genes, sox9and col2a1, to assess skeletal patterning during embryonic limb development in the direct‐developing salamander Plethodon cinereus. Limb patterning in P. cinereus partially resembles that described in other urodele species, with early formation of digit II and a generally anterior‐to‐posterior formation of preaxial digits. Unlike other salamanders described to date, differentiation of preaxial zeugopodial …

Killi-Data News, Tyrone Genade

Killifish Research Review

We have started a new project to aid killifish research and have made some progress towards creating an interactive website to which hobbyists and scientist can contribute data.

Biting The Hand That Feeds: Third Party Appeals And Nlra Objectives, Matthew Knowles

Fordham Urban Law Journal

No abstract provided.

Colby College Catalogue 2018-2019, Colby College

Colby Catalogues

No abstract provided.

The Effects Of Nutrient Limitation On Toxin Production For The Harmful Algal Bloom Species, Pseudo-Nitzschia, In The Gulf Of Maine, Julia M. Park

Honors Theses

Pseudo-nitzschia is a pennate marine diatom that produces the neurotoxin domoic acid (DA). Domoic acid accumulates in the digestive tract of filter feeders and becomes concentrated at higher trophic levels. When DA concentrations reach critical levels, consumption of toxic shellfish can induce a condition known as Amnesic Shellfish Poisoning (ASP), which has been responsible for the deaths of marine mammals, seabirds and humans. This study worked to respond to a toxic Pseudo-nitzschia bloom in the Gulf of Maine during the fall of 2016, with the goal of quantifying and identifying Pseudo-nitzschia spp. in the bloom region and to determine the …

Concert Recording 2018-03-11, Timothy Thompson, Tomoko Kashiwagi, Ronda Mains, Theresa Delaplain, Nophachai Cholthitchanta, Lia Uribe, Benjamin Pierce

Concert Recordings & Programs

[00:00]. Landscapes for clarinet, horn, and bassoon. Three scenes inspired by the life and work of landscape artist Frederic Edwin Church. Of tomorrow's promise: West Rock, New Haven, 1849 ; Of pain and sorrow: Twilight: Mount desert island, main, 1865 ; Of quiet reflection: Mount Katadhin from Millinocket Camp, 1895 / Daniel Baldwin -- [17:44]. Wind quintet no. 3. Prelude ; Bright and dark ; Finale Giocoso / Miguel del Aguila -- [33:25]. Haunted America suite for horn, tuba, and piano. La llorona ; Ghosts of Gettysburg ; Spooklight ; The bell witch / Justin Raines.

Terricolous Spiders (Araneae) Of Insecticide-Treated Spruce-Fir Forests In West-Central Maine, Daniel J. Hilburn, Daniel T. Jennings

The Great Lakes Entomologist

Spiders of 12 families, 42 genera, and at least 62 species were captured in linear-pitfall traps placed in insecticide-treated (Sevin-4-Oil®, Dipel 4L ®, Thuricide 16B®) and untreated spruce-fIr forests of west-central Maine. Species richness per family ranged from 1 (Theridiidae, Araneidae, Salticidae) to 19 (Erigonidae). Most trapped species were web-spinners (67.2%); most trapped individuals were hunters (75.2%). Lycosidae accounted for 66.1 % of all (n = 887) captured spiders. Total trapped spiders varied among insecticide treatments, sampling dates, and study sites. However, comparison of mean prespray and postspray trap catches indicated no significant reduction (ANOVA, ANCOVA, P 0.05) in terricolous …

Grindle, Charles, Gwendolyn Wolf, Johnna Ossie

Querying the Past: LGBTQ Maine Oral History Project Collection

Charles Grindle is a 66-year-old man from Ellsworth, ME. He is a piano player, as well as a minister. He has been heavily involved in church, music and theater since childhood. He has also done a lot of traveling- he’s lived in Portland, Boston, San Diego and England. He has years of experience working for churches- doing sermons and weddings, etc. In his earlier years, he played piano at many hopping places- such as The Front Porch and the Inn By the Sea. He worked at Blackstones when it first opened. Other bars that he frequented were Styxx and Rollins. …

Big Data: Computational Biology Opens A New Window On The World's Challenges For Colby Scientists, Kate Carlisle

Colby Magazine

"What makes us 'us' and not a plant? Not a bacteria, or a virus," asks Andrea Tilden, the J. Warren Merrill Associate Professor of Biology and a genomics expert. "Any one genome has six thousand novels worth of information. Computational biology is the tool we use to read them."

Search, The Jackson Laboratory

Search Magazine

No abstract provided.

Unh: The Magazine Of The University Of New Hampshire, Fall 2017, Unh Magazine

UNH Magazine

No abstract provided.

“The Boy Who Loved Too Much,” “The Original Ginny Moon” And Other Books Of Note, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Sebastian Râle (1652-1724) : In Commemoration Of His Martyrdom, Vincent Lapomarda S.J.

Holy Cross Bookshelf

Biography of Sabastien Râle, S.J., who served as a missionary to the Abenaki in the late 17th and early 18th centuries.

United States Records Of Williamsonia Fletcheri (Odonata: Corduliidae), G. H. Beatty, A. F. Beatty

The Great Lakes Entomologist

Excerpt: Foley (1966) reported specimens of Williamsonia fletcheri Williamson from rand Traverse County, Michigan as the first record of the species from the lower peninsula and "the second for the United States." However. two other records for the United States were overlooked and this was actually the fourth

A Pictoral Key And Annotated List Of Michigan Pseudoscorpions (Arachnida: Pseudoscorpionida), Gary V. Manley

The Great Lakes Entomologist

Excerpt: Berlese or Tullgren funnel methods of extraction of forest litter fauna often produce minute arthropods called pseudoscorpions. These are relatively common but have received little attention. Because of the author's involvement with the Michigan State University soil zoology research project the potential significance of these animals has become a matter of interest. The Pictorial Key (Figs. 1 and 2) has been designed to assist in the identification of Michigan pseudoscorpions, and will be a useful starting point for further study of our species. Because pseudoscorpions are predaceous on many soil arthropods (Hoff, 1949), they are important in soil arthropod …

Evolution Of Two Genomes: Impact Of Sequence Divergence On Mitochondrial Function, Tara Zeynep Baris

Open Access Dissertations

The oxidative phosphorylation pathway (OxPhos) is the only pathway where proteins are encoded by both the mitochondrial and nuclear genomes. It is also responsible for creating the majority of ATP used by animal cells. The critical role this pathway plays in animal cells, and it’s reliance on two genomes makes it a perfect system to study the co-evolution of the mitochondrial and nuclear genomes. Using Fundulus heteroclitus, an ectotherm inhabiting a steep thermal cline along the eastern coast of the United States, I explore the effect of temperature on the evolution of this important pathway, as well as the associations …

Lg Ms 007 Sturgis Haskins Papers Finding Aid, Siobain C. Monahan, Dani Y. Fazio, Anthony Marvullo

Search the Manuscript Collection (Finding Aids)

Description:

Sturgis Haskins was a long-time activist in Gay and Lesbian communities, and was one of the organizers of the annual Maine Gay Symposium started in 1974 at University of Maine, Orono. Haskins was a co- founder in 1973 of the Wilde-Stein Club, the first openly Gay student organization at the University of Maine in Orono. The Papers contain material documenting Haskins’ personal life, pamphlets, correspondence, memorabilia, and information on organizations in which Haskins was interested, and clippings covering topics relating to the Gay and Lesbian communities and homosexuality.

Date Range:

1966-1999

Size of Collection:

24 ft.

Annotation Of The Nuclear Receptors In An Estuarine Fish Species, Fundulus Heteroclitus, William S. Baldwin

Publications

The nuclear receptors (NRs) are ligand-dependent transcription factors that respond to various internal as well as external cues such as nutrients, pheromones, and steroid hormones that play crucial roles in regulation and maintenance of homeostasis and orchestrating the physiological and stress responses of an organism. We annotated the Fundulus heteroclitus (mummichog; Atlantic killifish) nuclear receptors. Mummichog are a non-migratory, estuarine fish with a limited home range often used in environmental research as a field model for studying ecological and evolutionary responses to variable environmental conditions such as salinity, oxygen, temperature, pH, and toxic compounds because of their hardiness. F. heteroclitus …