Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 99181 - 99210 of 2917681

Full-Text Articles in Entire DC Network

Virtual Reality’S Impact On Tourist Attitudes In Islamic Religious Tourism: Exploring Emotional Attachment And Vr Presence, Eman Alkhalifah, Ramy Hammady, Mahmoud Abdelrahman, Alyaa Darwish, Ella Cranmer, Ons Al-Shamaileh, Aikaterini Bourazeri, Timothy Jung Jun 2025

Virtual Reality’S Impact On Tourist Attitudes In Islamic Religious Tourism: Exploring Emotional Attachment And Vr Presence, Eman Alkhalifah, Ramy Hammady, Mahmoud Abdelrahman, Alyaa Darwish, Ella Cranmer, Ons Al-Shamaileh, Aikaterini Bourazeri, Timothy Jung

All Works

This study explores the integration of immersive technologies, specifically virtual reality (VR), to enhance tourist experiences in the rapidly expanding religious tourism sector. Despite VR’s potential, limited research has examined its impact on religious tourism. This study addresses this gap by investigating the role of emotional attachment in influencing VR presence during pre-, on-site, and postexperiences of VR-mediated religious tourism. A quantitative survey was conducted with 201 respondents who participated in VR religious tourism activities. The empirical analysis, conducted using SPSS and AMOS structural equation modeling (SEM), assessed how VR-mediated religious tourism impacts VR presence and tourist attitudes before actual …


How Transitioning Autistic Adults Consciously Perform Neurotypical Communication, Makenna J. Allred Jun 2025

How Transitioning Autistic Adults Consciously Perform Neurotypical Communication, Makenna J. Allred

Theses and Dissertations

Using semi-structured interviews this research explored the experiences of transitioning autistic adults with online communication. Participants shared information about navigating online communication, highlighting specific challenges such as interpreting tone and sarcasm, managing unspoken social norms, like emoji use, and responding to ambiguous or unexpected interactions. Participants shared that misunderstandings do occur in their online communication and how they recognize those miscommunications and strategize around preventing and mitigating them. These findings reveal that while computer-mediated communication offers opportunities for connection, it also presents unique obstacles that can exacerbate feelings of frustration due to miscommunications or misunderstandings. To prevent these social frictions …


Holistic Student Discipline: How A Proactive Empathetic Approach To Discipline Combined With Restorative Practices Can Change The Discipline Landscape, Melissa A. Dunworth Jun 2025

Holistic Student Discipline: How A Proactive Empathetic Approach To Discipline Combined With Restorative Practices Can Change The Discipline Landscape, Melissa A. Dunworth

Education Dissertations

Student discipline in the United States consists of a myriad of methods, including suspension, corporal punishment, isolation, seclusion, and restraint. Since the onset of COVID-19, students and staff have experienced an increase in trauma which has impacted the social-emotional skills of students and teacher burnout. Post-COVID student discipline requires a different approach to discipline combined with restorative practices, which can alter the discipline landscape. This qualitative case study investigates the impact of proactive empathetic discipline and Restorative Practices on student discipline, executive functioning, and school culture.

Grounded in Social Learning Theory, Self-Regulation Theory, and Respect for Children, this study examines …


Is Education Regulation The Solution To Help Lower Substance Use Rates And Substance Use Disorder In Oregon Youth?, Sophia R. Swain Jun 2025

Is Education Regulation The Solution To Help Lower Substance Use Rates And Substance Use Disorder In Oregon Youth?, Sophia R. Swain

Hatfield Graduate Journal of Public Affairs

How can we lower Oregon’s youth substance use disorder (SUD) and overdose rates? Oregon is third in the country for SUD, with 5.77% of adolescents (12-17) having documented SUD. Some claim that it is because of the decriminalization of drugs, like Senator Art Robinson, but another reason relies on how we are educating Oregon youth. Oregon education standards outline requirements for drug and alcohol education as well as Senate Bill 238. By analyzing school districts current prevention programs in high overdose-rate counties (Multnomah, Lane, and Josephine) and low overdose-rate counties (Washington, Yamhill, Linn, Deschutes, Marion, and Clackamas), a lack of …


Gen Z Hybristophilia: The Role Of Tiktok In Young Women’S Attraction To Deviant Men, Emma Virginia Treggia, Maria Ioannou, Calli Tzani, David Lester, Lucas Rogers, Thomas James Vaughan Williams, John Synnott, Michelle Drouin Jun 2025

Gen Z Hybristophilia: The Role Of Tiktok In Young Women’S Attraction To Deviant Men, Emma Virginia Treggia, Maria Ioannou, Calli Tzani, David Lester, Lucas Rogers, Thomas James Vaughan Williams, John Synnott, Michelle Drouin

Health Services and Informatics Research

This research explores hybristophilia (an individual’s sexual interest in and attraction to those who commit crimes) among Generation Z women, particularly through investigating how Gen Z female users interact with and feel about hybristophilic content and how this content impacts their attraction to offenders. Study 1 involved a content analysis of 66 videos and 91 comments on TikTok, identifying seven main themes: The Halo Effect, Actor-Offender Transference, Sympathy, Romance and APD, Protection and Loyalty, “I Can Fix Him,” Gen Z Irony, and Victim Fantasy. Study 2 used a cross-sectional survey with 95 women aged 18–27 to measure exposure to and …


Introduction To Clinical Psychology Syllabus (Psych 347), Valentina Nikulina Jun 2025

Introduction To Clinical Psychology Syllabus (Psych 347), Valentina Nikulina

Open Educational Resources

No abstract provided.


Insights Into The Floral Senescence Effects Of Nanoparticles, Vuk Uskoković Jun 2025

Insights Into The Floral Senescence Effects Of Nanoparticles, Vuk Uskoković

Administration and Staff Articles and Research

Flowers could be valuable addenda to nanomedicine labs as in vivo models crossing the gap between the cell culture and small mammals. However, as it is shown here, floral models continue to be predominantly utilized within resource-limited research environments and remain largely underrepresented in mainstream biomedical investigations conducted by well-funded institutions in the developed world. The ability to delay the senescence of Orange Jubilee wildflowers was tested here on three types of nanoparticles: selenite-doped hydroxyapatite (HAp), citrate-stabilized HAp, and superparamagnetic iron oxide. Integration of selenite into the HAp crystal lattice produced a mild increase in the senescence rate …


Towards A Robust Hydrologic Data Assimilation System For Hurricane-Induced River Flow Forecasting, Peyman Abbaszadeh, Fatemah Gholizadeh, Keyhan Gavahi, Hamid Moradkhani Jun 2025

Towards A Robust Hydrologic Data Assimilation System For Hurricane-Induced River Flow Forecasting, Peyman Abbaszadeh, Fatemah Gholizadeh, Keyhan Gavahi, Hamid Moradkhani

Civil and Environmental Engineering Faculty Publications and Presentations

The Hybrid Ensemble and Variational Data Assimilation framework for Environmental Systems (HEAVEN) is a method developed to enhance hydrologic model predictions while accounting for different sources of uncertainties involved in various layers of model simulations. While the effectiveness of this data assimilation in forecasting streamflow has been proven in previous studies, its potential to improve flood forecasting during extreme events remains unexplored. This study aims to demonstrate this potential by employing HEAVEN to assimilate streamflow data from United States Geological Survey (USGS) stations into a conceptual hydrologic model to enhance its capability to forecast hurricane-induced floods across multiple locations within …


Matter Of Promenade Nelson Apts. Llc V. New York State Div. Of Hous. & Community Renewal Jun 2025

Matter Of Promenade Nelson Apts. Llc V. New York State Div. Of Hous. & Community Renewal

All Decisions

In an Article 78 proceeding regarding a Major Capital Improvement (MCI) rent increase, the appellate court reversed a lower court's denial of the landlord's petition. The court held that while DHCR's retroactive application of the HSTPA to the landlord's pending MCI application was rational, the agency failed to establish a rational basis for its determination that certain installations exceeded the scope of necessary work. The matter was remanded to DHCR because the agency also failed to address the merits of the landlord's argument that the disputed costs were required for code compliance.


Unh Leadership Visits Armi, Boys & Girls Clubs Of Greater Manchester, Amy Slattery Jun 2025

Unh Leadership Visits Armi, Boys & Girls Clubs Of Greater Manchester, Amy Slattery

UNH Today Archive

No abstract provided.


Olfaction And Plasma Biomarkers Of Alzheimer Disease And Neurodegeneration In The Atherosclerosis Risk In Communities Study, Srishti Shrestha, Xiaoqian Zhu, Michael E Griswold, Priya Palta, Kevin J Sullivan, Honglei Chen, Andrea Lauren Christman Schneider, Abhay Moghekar, Megan L Grove, Bharat Thyagarajan, James Russell Pike, Rebecca F Gottesman, B Gwen Windham, Thomas H Mosley, Jennifer A Deal, Vidyulata Kamath Jun 2025

Olfaction And Plasma Biomarkers Of Alzheimer Disease And Neurodegeneration In The Atherosclerosis Risk In Communities Study, Srishti Shrestha, Xiaoqian Zhu, Michael E Griswold, Priya Palta, Kevin J Sullivan, Honglei Chen, Andrea Lauren Christman Schneider, Abhay Moghekar, Megan L Grove, Bharat Thyagarajan, James Russell Pike, Rebecca F Gottesman, B Gwen Windham, Thomas H Mosley, Jennifer A Deal, Vidyulata Kamath

Faculty, Staff and Student Publications

Background and objectives: Investigation of olfactory impairment, an early manifestation of Alzheimer disease (AD), in relation to plasma biomarkers of AD and neurodegeneration could provide insights into the disease's pathophysiology. Because few such studies based on large, diverse, community-based populations exist, we investigated associations of odor identification ability with plasma biomarkers of AD and other neurodegenerative pathologies in community-dwelling Black and White older adults.

Methods: This cross-sectional investigation included participants from the Atherosclerosis Risk in Communities study who attended visit 5 (2011-2013) and who completed olfactory testing and brain MRI examinations and had plasma biomarkers measured (namely, amyloid-beta [Aβ]42/Aβ40 ratio, …


Legacy Of Knowledge: George Wythe's Law Library & The Shaping Of American Thought, Osher Lifelong Learning Institute, The Williamsburg Institute Jun 2025

Legacy Of Knowledge: George Wythe's Law Library & The Shaping Of American Thought, Osher Lifelong Learning Institute, The Williamsburg Institute

Library Events

No abstract provided.


No. 109 An Order For Tennessee To Lead The Nation In Workforce Development, Bill Lee Jun 2025

No. 109 An Order For Tennessee To Lead The Nation In Workforce Development, Bill Lee

Executive Orders

No abstract provided.


Enhancing Dementia Classification For Diverse Demographic Groups: Using Vision Transformer-Based Continuous Scoring Of Clock Drawing Tests., Mengyao Hu, Yi Lu Murphey, Tian Qin, Edmundo R Melipillán, Laura B Zahodne, Richard Gonzalez, Vicki A Freedman Jun 2025

Enhancing Dementia Classification For Diverse Demographic Groups: Using Vision Transformer-Based Continuous Scoring Of Clock Drawing Tests., Mengyao Hu, Yi Lu Murphey, Tian Qin, Edmundo R Melipillán, Laura B Zahodne, Richard Gonzalez, Vicki A Freedman

Faculty, Staff and Student Publications

Objectives: Alzheimer's disease and related dementias significantly affect older adults' quality of life. The clock-drawing test (CDT) is a widely used dementia screening tool due to its ease of administration and effectiveness. However, manual CDT-coding in large-scale studies can be time-intensive and prone to coding errors and is typically limited to ordinal responses. In this study, we developed a continuous CDT score using a deep learning neural network (DLNN) and evaluated its ability to classify participants as having dementia or not.

Methods: Using a nationally representative sample of older adults from the National Health and Aging Trends Study (NHATS), we …


Measuring What Matters To Patients: A Multiple Methods Sequential Study Of Disease Burden, Quality Of Life, And The Alignment Of Patient-Reported Outcome Measurements For High-Risk Myelodysplastic Syndrome And Acute Myelogenous Leukemia Patients, Anthony J. Messina Jun 2025

Measuring What Matters To Patients: A Multiple Methods Sequential Study Of Disease Burden, Quality Of Life, And The Alignment Of Patient-Reported Outcome Measurements For High-Risk Myelodysplastic Syndrome And Acute Myelogenous Leukemia Patients, Anthony J. Messina

Doctor of Philosophy in Translational Health Sciences Dissertations

Background

High-risk myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are aggressive hematologic malignancies with poor prognoses, where extending survival often comes at the cost of substantial morbidity. This study was grounded in the quality of survival (QoS) framework, which emphasizes that treatment outcomes should balance longevity with the health-related quality of life (HRQoL) experienced during the period of survival. In this context, patient-reported outcomes are crucial to capturing what truly matters to patients. However, existing patient-reported outcome measures (PROMs) used in MDS/AML clinical trials may not fully reflect patient priorities. A complementary Wilson–Cleary model perspective, linking biological factors to …


Histotripsy: A Novel Non-Invasive Ultrasound Technology For Precision Thrombolysis In Acute Ischemic Stroke Management, Ameer E. Hassan, Thomas Dreyer, Yousef Khalili Jun 2025

Histotripsy: A Novel Non-Invasive Ultrasound Technology For Precision Thrombolysis In Acute Ischemic Stroke Management, Ameer E. Hassan, Thomas Dreyer, Yousef Khalili

School of Medicine Publications

BackgroundStroke remains a major cause of morbidity and mortality worldwide. Traditional treatments for ischemic stroke such as mechanical thrombectomy and pharmacological thrombolysis are often less effective or inaccessible for certain patient populations, particularly those with delayed hospital arrival, contraindications to thrombolytics, or in regions with limited access to endovascular care. This study investigates the feasibility of using histotripsy, a non-invasive ultrasound technology, to precisely liquefy thrombi in an artificial experimental setup.MethodsClot analogs were introduced into sample tubes, and focused ultrasound was applied using optimized parameters, including pulses per burst, repetition rates, and output amplitudes. These parameters were systematically adjusted to …


Structure-Function Coupling In The First Month Of Life: Associations With Age And Attention, Ursula A Tooley, Jeanette K Kenley, M Catalina Camacho, Aidan Latham, Dimitrios Alexopoulos, Ashley N Nielsen, Tara A Smyser, Barbara B Warner, Joshua S Shimony, Jeffrey J Neil, Joan L Luby, Deanna M Barch, Cynthia E Rogers, Christopher D Smyser Jun 2025

Structure-Function Coupling In The First Month Of Life: Associations With Age And Attention, Ursula A Tooley, Jeanette K Kenley, M Catalina Camacho, Aidan Latham, Dimitrios Alexopoulos, Ashley N Nielsen, Tara A Smyser, Barbara B Warner, Joshua S Shimony, Jeffrey J Neil, Joan L Luby, Deanna M Barch, Cynthia E Rogers, Christopher D Smyser

2020-Current year OA Pubs

How brain structure relates to function is a critical and open question in neuroscience. Here, we characterize regional variation in structure-function coupling, capturing the degree to which a cortical region's structural connections relate to patterns of coordinated neural activity in healthy, term-born neonates (


Toward Culturally Responsive Interpretation: Native American Histories, Lifeways, And Ways Of Knowing At The High Desert Museum, Carol Fitzsimmons, Ajena Cason Rogers Jun 2025

Toward Culturally Responsive Interpretation: Native American Histories, Lifeways, And Ways Of Knowing At The High Desert Museum, Carol Fitzsimmons, Ajena Cason Rogers

Dissertations

Many public museums and historic institutions reflect settler colonial culture and are primarily non-Native led. Although these institutions are trusted, many have perpetuated cultural harm through the theft of belongings, the misrepresentation of stories and histories, and the inaccurate portrayals of cultural content. When interpreting Native American experiences, many non-Native institutions struggle to co-create culturally responsive interpretation. The purpose of this basic qualitative study was to apply the four-truth framework, developed by the South African Truth and Reconciliation Commission, to better understand how the High Desert Museum approached the interpretation of Native American content and stories and to explore how …


Exploring The Feasibility Of Using Virtual Reality With Children With Autism, Gemma Leighton Jun 2025

Exploring The Feasibility Of Using Virtual Reality With Children With Autism, Gemma Leighton

Theses and Dissertations

This study explored the feasibility and social validity of teenagers with autism spectrum disorder (ASD) using a virtual reality (VR) head-mounted display (HMD). VR is emerging as a promising tool for teaching and therapeutic intervention among ASD. Therefore, this study serves to contribute to the field's development by comprehensively evaluating the accessibility for young people with ASD to independently using a VR HMD in a meaningful way. Five teenagers participated (four female, aged 13-15, with mild and mild to moderate support needs) and independently completed tutorials in a virtual environment when learning to operate the VR HMD controllers and hand-tracking …


Semitic Root Encoding: Tokenization Based On The Templatic Morphology Of Semitic Languages In Nmt, Brendan T. Hatch Jun 2025

Semitic Root Encoding: Tokenization Based On The Templatic Morphology Of Semitic Languages In Nmt, Brendan T. Hatch

Theses and Dissertations

The morphological structure of Semitic languages like Arabic and Hebrew is based on non-concatenative roots and templates. This complex word structure used by humans is obscured to neural models that use traditional tokenization algorithms. In this work, I present and evaluate Semitic Root Encoding (SRE), a tokenization method that represents Semitic words with distinct root and template stem tokens, and apply it to neural machine translation (NMT). I evaluate whether tokenization with the SRE method leads to increases in translation quality, whether it allows NMT models to hypothesize unseen word forms needed at inference, and how impervious resulting NMT models …


Application Of Claims-Based Frailty Index To A Structured Electronic Health Record Data, Min Ji Kwak, Caroline Schaefer, Youngran Kim, Sunyang Fu, Chan Mi Park, Abhijeet Dhoble, Nahid Rianon, Holly M Holmes, Dae Hyun Kim Jun 2025

Application Of Claims-Based Frailty Index To A Structured Electronic Health Record Data, Min Ji Kwak, Caroline Schaefer, Youngran Kim, Sunyang Fu, Chan Mi Park, Abhijeet Dhoble, Nahid Rianon, Holly M Holmes, Dae Hyun Kim

Faculty, Staff and Student Publications

Background: The Claims-based Frailty Index (CFI) has been developed and validated using Medicare claims data. However, whether CFI can be applied to structured electronic health record data has not been studied.

Methods: We applied the CFI to a structured electronic health record dataset (Explorys dataset) and a Medicare fee-for-service 5% sample data and compared the prevalence of frailty from each dataset, using the cohort of older adults. Then, we assessed the odds ratio and area under the curve of the frailty predicting adverse clinical outcomes, any hospital or emergency room visit, or any adverse drug events related encounter within 1 …


Neat Vs. Scruffy: How Early Ai Researchers Classified Epistemic Cultures Of Knowledge Representation, Lindsay Poirier Jun 2025

Neat Vs. Scruffy: How Early Ai Researchers Classified Epistemic Cultures Of Knowledge Representation, Lindsay Poirier

Statistical and Data Sciences: Faculty Publications

Accounts of the history of symbolic artificial intelligence (AI) often categorize researchers and their programs through binary oppositions: logicist versus procedural, or alternatively, neat versus scruffy. These terms were often referenced throughout the 1970s and 1980s by AI researchers at institutions in the United States and Europe to document epistemic and esthetic differences in approaches to knowledge representation. In this article, I historicize and situate these binary oppositions, showing how researchers leveraged them in discourse to demarcate the beliefs and commitments underpinning certain AI approaches. I argue that the labels helped knowledge representation scholars identify, trouble, and grapple with the …


Optimal Well Being Of Those Recovering From Alcohol Use Disorder: An Exploration Of Individual Difference Factors And Treatment Outcomes, Jared Davis Jun 2025

Optimal Well Being Of Those Recovering From Alcohol Use Disorder: An Exploration Of Individual Difference Factors And Treatment Outcomes, Jared Davis

USF Tampa Graduate Theses and Dissertations

Harmful alcohol use has continued to be one of the largest negative impact factors of daily living worldwide. Despite the pervasive use of alcohol and negative impacts that it has on the individual and society there is large disagreement on how to know when someone has “recovered” from AUD (El-Guebaly, 2012), with much of the literature focused narrowly on negative indicators (e.g., return to heavy drinking, re-occurrence of AUD symptoms). Such views have not only restricted definitions of recovery but has also created public perception that those with AUD will continue to struggle even when cessation of drinking has occurred. …


More Equal Than Others: Taxonomic Bias In Animal Management, Barrett L. Christie Jun 2025

More Equal Than Others: Taxonomic Bias In Animal Management, Barrett L. Christie

Animal Sentience

Oldfield & Bonano (2024) point out not only the scarcity of research on fish welfare but also significant taxonomic bias in broader research on these species. This bias extends to the management practices of aquaria and zoos, where the focus is on higher vertebrates. More resources need to be allocated to research to address this disparity. We also need to develop welfare constructs that recognize the inherent differences between aquatic and terrestrial species, taking into account the unique ecological contexts and behavioral patterns of fishes.


Leveraging An Arts-Based Approach To Foster Engagement, Nurture Kindness, And Prevent Violence, Yok-Fong Paat, Diego Garcia Tovar, Nathan W. Myers, Max C. E. Orezzoli, Anne M. Giangiulio, Sarah L. Ruiz, Angela V. Dorado, Luis R. Torres-Hostos Jun 2025

Leveraging An Arts-Based Approach To Foster Engagement, Nurture Kindness, And Prevent Violence, Yok-Fong Paat, Diego Garcia Tovar, Nathan W. Myers, Max C. E. Orezzoli, Anne M. Giangiulio, Sarah L. Ruiz, Angela V. Dorado, Luis R. Torres-Hostos

School of Social Work Faculty Publications

Drawing from the insights of community partners, this study explored the roles and benefits of arts-based approaches to foster civic learning, critical media literacy, and community engagement. It also uncovered approaches to promote kindness, prevent violence, and combat online extremism, offering insights into strategies that may enhance community engagement and create a positive impact. We presented our model framework, a detailed case study of our project, and qualitative methods incorporating 15 interviews with our community partners to capture a broad range of perspectives and experiences. Interviewees were community partners who collaborated with our project in organizing events and activities using …


Real Estate Board Of New York, Inc. V. The City Of New York Jun 2025

Real Estate Board Of New York, Inc. V. The City Of New York

All Decisions

The court denied a preliminary injunction against New York City's FARE Act, which shifts broker fee payment from tenants to landlords. The judge granted in part the City's motion to dismiss, striking down plaintiffs' First Amendment, New York State Constitution, and state law preemption claims. However, the Contracts Clause claim was allowed to proceed. The court emphasized that it cannot overturn legislation based on policy disagreements.


Symbiotic International Law: Combatting Uyghur Forced Labor, Preston Jordan Lim Jun 2025

Symbiotic International Law: Combatting Uyghur Forced Labor, Preston Jordan Lim

Faculty Publications

Since 2017, the Chinese government has launched a campaign of repression against the Muslim Turkic minorities of Xinjiang, a region located in China’s Northwest. While most scholars have focused on the mass internment of Uyghurs and other minorities, this Article highlights an under-discussed aspect of China’s campaign: the construction of a sophisticated forced labor system. Minority forced labor supplies key sectors of the global economy—from the automotive to the energy sectors—and allows Chinese companies to outcompete foreign firms. The unprecedented scope and sophistication of what I term the “modern Xinjiang forced labor system” imperils the very future of the international …


Structural Basis For The Substrate Specificity Of Helix Pomatia Amp Deaminase And A Chimeric Adgf Adenosine Deaminase, Gundeep Kaur, John R Horton, George Tzertzinis, Jujun Zhou, Ira Schildkraut, Xiaodong Cheng Jun 2025

Structural Basis For The Substrate Specificity Of Helix Pomatia Amp Deaminase And A Chimeric Adgf Adenosine Deaminase, Gundeep Kaur, John R Horton, George Tzertzinis, Jujun Zhou, Ira Schildkraut, Xiaodong Cheng

Faculty, Staff and Student Publications

Helix pomatia AMP deaminase (HPAMPD), an enzyme enriched in the foot muscle of the mollusk H. pomatia, exhibits deaminase activity on adenosine-5'-monophosphate (AMP). HPAMPD is the first member of the adenosine deaminase-related growth factor (ADGF) family to prefer the nucleotide AMP over the nucleoside adenosine. To investigate the substrate selectivity of HPAMPD, we determined its structure in both the apo form and in complex with the adenosine analogs pentostatin and pentostatin-5'-monophosphate. Structurally, HPAMPD adopts a fold similar to human ADA2, an ADGF family member. HPAMPD has acquired the ability to interact with the 5'-monophosphate group of AMP through polar and …


Sickle Cell Disease Induces Chromatin Introversion And Ferroptosis In Cd8+ T Cells To Suppress Anti-Tumor Immunity, Zilong Zhao, Benxia Hu, Yalan Deng, Melinda Soeung, Jun Yao, Lanxin Bei, Yaohua Zhang, Pengju Gong, Lisa A Huang, Zhou Jiang, Jian Gao, Shuang Peng, Tina K Nguyen, Menuka Karki, Bora Lim, Cassian Yee, Jared K Burks, Qing Zhang, Li Ma, Jianjun Gao, Nizar M Tannir, Leng Han, Dihua Yu, Linghua Wang, Michael A Curran, Maria A Gubbiotti, Giannicola Genovese, Boyi Gan, Wenbo Li, Pavlos Msaouel, Liuqing Yang, Chunru Lin Jun 2025

Sickle Cell Disease Induces Chromatin Introversion And Ferroptosis In Cd8+ T Cells To Suppress Anti-Tumor Immunity, Zilong Zhao, Benxia Hu, Yalan Deng, Melinda Soeung, Jun Yao, Lanxin Bei, Yaohua Zhang, Pengju Gong, Lisa A Huang, Zhou Jiang, Jian Gao, Shuang Peng, Tina K Nguyen, Menuka Karki, Bora Lim, Cassian Yee, Jared K Burks, Qing Zhang, Li Ma, Jianjun Gao, Nizar M Tannir, Leng Han, Dihua Yu, Linghua Wang, Michael A Curran, Maria A Gubbiotti, Giannicola Genovese, Boyi Gan, Wenbo Li, Pavlos Msaouel, Liuqing Yang, Chunru Lin

Faculty, Staff and Student Publications

Understanding how genetic disorders affect CD8+ T cells in the tumor microenvironment is key to improving cancer immunotherapy. Individuals with sickle cell disease (SCD), the most prevalent inherited blood disorder, have a higher risk of developing certain cancers than the general population, but the mechanisms driving this increased risk remain unclear. Our study revealed that SCD altered CD8+ T cell 3D genome architecture, triggering ferroptosis and weakening anti-tumor immunity, thereby promoting tumor growth. Using murine and humanized SCD models, we found that disrupted chromosomal interactions in CD8+ T cells reduced the expression of anti-ferroptotic genes, including SLC7A11 and hydrogen sulfide …


Sickle Cell Disease Induces Chromatin Introversion And Ferroptosis In Cd8+ T Cells To Suppress Anti-Tumor Immunity, Zilong Zhao, Benxia Hu, Yalan Deng, Melinda Soeung, Jun Yao, Lanxin Bei, Yaohua Zhang, Pengju Gong, Lisa A Huang, Zhou Jiang, Jian Gao, Shuang Peng, Tina K Nguyen, Menuka Karki, Bora Lim, Cassian Yee, Jared K Burks, Qing Zhang, Li Ma, Jianjun Gao, Nizar M Tannir, Leng Han, Dihua Yu, Linghua Wang, Michael A Curran, Maria A Gubbiotti, Giannicola Genovese, Boyi Gan, Wenbo Li, Pavlos Msaouel, Liuqing Yang, Chunru Lin Jun 2025

Sickle Cell Disease Induces Chromatin Introversion And Ferroptosis In Cd8+ T Cells To Suppress Anti-Tumor Immunity, Zilong Zhao, Benxia Hu, Yalan Deng, Melinda Soeung, Jun Yao, Lanxin Bei, Yaohua Zhang, Pengju Gong, Lisa A Huang, Zhou Jiang, Jian Gao, Shuang Peng, Tina K Nguyen, Menuka Karki, Bora Lim, Cassian Yee, Jared K Burks, Qing Zhang, Li Ma, Jianjun Gao, Nizar M Tannir, Leng Han, Dihua Yu, Linghua Wang, Michael A Curran, Maria A Gubbiotti, Giannicola Genovese, Boyi Gan, Wenbo Li, Pavlos Msaouel, Liuqing Yang, Chunru Lin

Faculty, Staff and Student Publications

Understanding how genetic disorders affect CD8