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Umn Morris Welcomes Distinguished Visiting Professor Todd Richardson, Communications And Marketing

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Bridging The Gap: Exploring Veteran Students' Transition From Military Service To Higher Education, Edward Lewis King Sr.

Graduate Student Dissertations, Theses, Capstones, and Portfolios

Transitioning from military to civilian life can present many challenges for military personnel. Veterans often face difficulties adjusting from the structured and hierarchical environment of the military to the more fluid and unstructured nature of civilian life and the flexibility of higher education. The purpose of this qualitative, narrative inquiry study was to explore the challenges veterans face when transitioning from military service to higher education. The secondary purpose was to develop a webinar series, King Veteran Success 360, to mitigate obstacles student-veterans encounter during this transition. Schlossberg's transition theory was the theoretical framework that guided this inquiry to identify …

Encorafenib, Cetuximab, And Mfolfox6 In Braf-Mutated Colorectal Cancer, Elena Elez, Takayuki Yoshino, Lin Shen, Sara Lonardi, Eric Van Cutsem, Cathy Eng, Tae Won Kim, Harpreet Singh Wasan, Jayesh Desai, Fortunato Ciardiello, Rona Yaeger, Timothy S Maughan, Van K Morris, Christina Wu, Tiziana Usari, Robert Laliberte, Samuel S Dychter, Xiaosong Zhang, Josep Tabernero, Scott Kopetz, Breakwater Trial Investigators

Faculty, Staff and Student Publications

Background: First-line treatment with encorafenib plus cetuximab (EC) with or without chemotherapy (oxaliplatin, leucovorin, and fluorouracil [mFOLFOX6]) for BRAF V600E-mutated metastatic colorectal cancer, an aggressive subtype with a poor prognosis, was compared with standard care (chemotherapy with or without bevacizumab) in an open-label, phase 3 trial, which showed significance regarding one of the two primary end points, objective response according to blinded independent central review (odds ratio for EC+mFOLFOX6 vs. standard care, 2.44; one-sided P< 0.001). This result led to accelerated Food and Drug Administration approval of this investigational combination therapy for BRAF V600E-mutated metastatic colorectal cancer, including as first-line therapy. Data on progression-free survival (the second primary end point) and an updated interim analysis of overall …

Mis-Splicing-Derived Neoantigens And Cognate Tcrs In Splicing Factor Mutant Leukemias, Won Jun Kim, Edie I Crosse, Emma De Neef, Inaki Etxeberria, Erich Y Sabio, Eric Wang, Jan Philipp Bewersdorf, Kuan-Ting Lin, Sydney X Lu, Andrea Belleville, Nina Fox, Cynthia Castro, Pu Zhang, Takeshi Fujino, Jennifer Lewis, Jahan Rahman, Beatrice Zhang, Jacob H Winick, Alexander M Lewis, Robert F Stanley, Susan Dewolf, Brigita Meškauskaitė Urben, Meril Takizawa, Tobias Krause, Henrik Molina, Ronan Chaligne, Priya Koppikar, Jeffrey Molldrem, Mathieu Gigoux, Taha Merghoub, Anthony Daniyan, Smita S Chandran, Benjamin D Greenbaum, Christopher A Klebanoff, Robert K Bradley, Omar Abdel-Wahab

Faculty, Staff and Student Publications

Mutations in RNA splicing factors are prevalent across cancers and generate recurrently mis-spliced mRNA isoforms. Here we identified a series of bona fide neoantigens translated from highly stereotyped splicing alterations promoted by neomorphic, leukemia-associated somatic splicing machinery mutations. We utilized feature-barcoded peptide-MHC dextramers to isolate neoantigen-reactive T cell receptors (TCRs) from healthy donors, patients with active myeloid malignancy, and following curative allogeneic stem cell transplant. Neoantigen-reactive CD8+ T cells were present in the blood of patients with active cancer and had a distinct phenotype from virus-reactive T cells with evidence of impaired cytotoxic function. T cells engineered with TCRs recognizing …

Strategies Health Care Leaders Use For Telemedicine Utilization And Subsequent Revenue Enhancement, Wesley Raymond Wingate

Walden Dissertations and Doctoral Studies

Health care leaders face challenges in increasing the utilization of alternative synchronous health care platforms, such as telemedicine, which enable real-time virtual consultations, which can influence in-person clinic visits and impact organizational revenue. Rising demand for accessible health care, and ineffective telemedicine implementation limits patient access and overall organizational sustainability, increasing the need for evidence-based strategies critical for health care leaders to improve both service delivery and financial outcomes. This qualitative pragmatic inquiry, grounded in the health belief model, aimed to explore strategies used by health care leaders in the South Texas region to implement telemedicine effectively. The participants included …

Examination Of Evidence-Based Practices Implementation And Perceived Job Satisfaction With Mental Health Providers, Rafael Montoya

Walden Dissertations and Doctoral Studies

Job satisfaction among mental health providers continues to be an important area of inquiry, particularly in relation to professional development and training. However, limited studies have evaluated whether training in evidence-based practices (EBPs) is associated with different levels of job satisfaction compared to traditional training models. The purpose of this cross-sectional, quantitative study was to examine whether a statistically significant difference in job satisfaction exists between mental health providers trained in EBPs and those trained using traditional approaches. The study was guided by Spector’s multidimensional job satisfaction model, which categorizes job satisfaction into nine key domains. Data from 81 mental …

Incidence, Risk Factors And Clinical Outcomes Of Pericardial Effusion In Left Ventricular Assist Device Patients, Muhammad Zubair Khan, Yevgeniy Brailovsky, Mohammad Alfrad Nobel Bhuiyan, Gregary D. Marhefka, Abu S. M. Faisal, Adrija Sircar, Parker O'Neill, J. Eduardo Rame, Sona Franklin, Muhammad Waqas, Hadia Shah, Indranee Rajapreyar, René J. Alvarez

Division of Cardiology Faculty Papers

BACKGROUND: Development of pericardial effusion in patients with left ventricular assist devices (LVADs) can be detrimental to health outcomes. This study aims to elucidate the prevalence and risk factors for pericardial effusion in patients with LVADs.

AIM: To elucidate risk factors associated with the presence of pericardial effusion in patients with LVADs and compare the clinical outcomes of those with and without pericardial effusion. The secondary goal is to determine the incidence of pericardiocentesis and pericardial window placement in patients with LVADs experiencing pericardial effusion.

METHODS: Data were obtained from the National Inpatient Sample database between 2016 and 2018. Statistical …

The Dynamic Responses Of The Mouse Gut Microbiome To Dietary Supplementation With Various Anthocyanin-Rich Foods In The Context Of A Western Diet, Abby D. Benninghoff

Browse all Datasets

Background/Objectives: Chronic inflammation and Western-style diets elevate colorectal cancer (CRC) risk, particularly in individuals with colitis, a feature of inflammatory bowel disease (IBD). Diets rich in polyphenol-containing functional foods, such as cocoa, may reduce gut inflammation and modulate the gut microbiome. This study examined the effects of cocoa polyphenol (CP) supplementation on inflammation and microbiome composition before, during, and after colitis in mice fed either a healthy or Western diet. We hypothesized that CPs would attenuate inflammation and promote distinct micro-biome shifts, especially in the context of a Western diet. Methods: A 2×2 factorial design tested the effects of basal …

Santa, Socials, And Secrets: Hard Cases For Epistemic Rights, Étienne Brown, Rebecca Chan

Faculty Research, Scholarly, and Creative Activity

In The Right to Know, Lani Watson forcefully argues in favor of recognizing epistemic rights to all humans. In this paper, we apply Watson’s framework to three hard cases. First, we consider interpersonal relationships and suggest that there is room to explore how epistemic rights bear on, e.g., whether parents can permissibly lie to or mislead their children by asserting the existence of Santa Claus. Second, we turn to social media platforms and contend that Watson’s framework is compatible with contrasting moderation policies and transparency requirements. Third, we examine a foundational case of legal ethics—the buried bodies case—which raises the …

The Meaning And Essence Of Depression And Loneliness In Widowhood: Discovering The Healthy Construct Of Self-Efficacy, Christine M. Ward

Doctoral Dissertations and Projects

The purpose of this phenomenological study will be to describe the lived experience of widows aged 65-80 who lost their husbands within the past five years in one of three counties in Washington State: Pierce, Kitsap, or Mason. The two theories guiding this study will be Bowlby’s Attachment Theory and Bandura’s Social Learning Theory, (SLT), as they relate to post-loss identity and mourning. Both serve as vital tools for surviving and recovering from the impact of losing a spouse. When these affectional attachments are lost, a widow’s quality of life can be lessened or even damaged. A widow will go …

Pastoring The Pastor: Self-Care Among African American Clergy, Alexander Jamerison

Doctoral Dissertations and Projects

When self-care is effectively implemented, it can help individuals avoid or reduce mental health challenges throughout their lives (Luis et al., 2021). Unfortunately, research indicates numerous mental health challenges faced by clergy (Chan & Chen, 2019; Jackson, 2013; Gallagher, 2019; Edward, 2020). To assist ministers in cultivating a healthier life and a more effective ministry, this study will specifically explore the relationship between self-care and mental health challenges among African American clergy. The literature on this subject will identify historical, cultural, and spiritual influences. It will also examine specific mental health concerns, effective self-care practices, and relevant outcomes. Although research …

Media Richness In Nfl Communications: A Content Analysis Case Study, Ashley Menard

Doctoral Dissertations and Projects

This qualitative study aimed to examine the social media engagement of fans of the National Football League (NFL). The central problem identified was a lack of understanding of brand storytelling across different social media platforms, particularly concerning the richness of information each platform provided. Guided by media richness theory, developed by Daft and Lengel, this research explored the varying communication styles employed in brand storytelling on social media. The study sought to provide insights into how NFL brands can effectively utilize different platforms to enhance their storytelling and engage with their audience more richly and effectively. The results indicate that …

To Use Or Not To Use Exclusionary Discipline In Early Childhood Education? A Phenomenological Analysis Of Pre-Kindergarten Teachers In Alabama, Christal C. Coker

Doctoral Dissertations and Projects

This qualitative phenomenological study was conducted to examine the lived experiences of pre- kindergarten teachers in Alabama regarding their use of and restraint from using exclusionary discipline. The study aimed to find outcomes that could potentially improve social contexts in Alabama's preschools by creating more equitable learning environments. The problem addressed by the study is that the lived experience of preschool teachers regarding their use of and restraint from using exclusionary discipline when students misbehave at school remains to be discovered. A purposive sampling strategy was employed to recruit seven preschool teachers licensed in Alabama for a one-on-one semi-structured Zoom …

Entire Issue Vol. 14 No. 2

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

Vol 14(2)

Atomic And/Or Renewable Energy Sources In The Mitigation Of Climate Change In Czech Law, Milan Damohorský

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

Niniejszy artykuł podejmuje analizę ram prawnych regulujących funkcjonowanie energetyki jądrowej oraz odnawialnych źródeł energii w Czechach, ze szczególnym uwzględnieniem ich roli w procesie przeciwdziałania zmianie klimatu. W obliczu rosnącego zapotrzebowania na energię oraz pogłębiających się globalnych problemów środowiskowych, czeski porządek prawny ulega dostosowaniom odpowiadającym na wyzwania związane z ochroną klimatu, bezpieczeństwem energetycznym oraz transformacją w kierunku zrównoważonych źródeł energii. Przeprowadzona analiza uwypukla wzajemne relacje pomiędzy krajowym ustawodawstwem czeskim a dyrektywami Unii Europejskiej, a także identyfikuje konflikty prawne i środowiskowe, które pojawiają się w praktyce wdrażania rozwiązań opartych na odnawialnych i jądrowych źródłach energii. Artykuł omawia ponadto kierunki polityki energetycznej oraz …

Decreasing Medication Errors Among Unlicensed Assistive Personnel, Tamara J. Carroll

Doctoral Dissertations and Projects

Unlicensed assistive personnel, although their role is controversial, are present in many different settings and have many varying roles and job responsibilities. Yet, removing this type of healthcare worker from the job pool may lead to increased labor costs, which could be stifling to some organizations and facilities. Digging deeper, data suggests errors are due to lack of a defined scope of practice, a lack of understanding of job roles and responsibilities and decreased confidence when working in the healthcare setting. The purpose of this project utilizes a setting specific educational intervention and skills check off to increase job self-efficacy …

Quantifying Experiences Of Religious Abuse Among Sexual And Gender Minority Populations, Joshua Sink

Doctoral Dissertations and Projects

A niche venue of research around religious trauma and spiritual abuse has demonstrated adverse outcomes of individuals who feel manipulated or harmed by institutions or individuals holding an imbalance of religious power. While general claims are often made that religion is a positive force on health and psychological wellness, religious trauma is usually associated with PTSD, anxiety, depression, and other pathological symptoms. Interestingly, an area where religion is not related to positive outcomes is among sexual and gender minorities, who show poorer health, higher suicidal rates, and poorer psychological well-being correlated with higher religiosity. While research has been conducted to …

Collegiate Music Recruiting: Using Athletic Recruiting Best Practices To Transform The Industry, Larry Jay Giddens Jr.

Doctoral Dissertations and Projects

The recruitment of new students is vital to every music program and can have a tremendous impact on its success. As technology evolves and the needs of the world change, so do the methods of student recruitment and retention in music departments, music schools, and colleges of music. This study covers the perspectives of collegiate music unit recruiters and compares current and potential strategies. Using a mixed methods approach, this research employs surveys to identify current music unit recruiting trends and challenges. Online recruiting, scholarship availability and facilities/staff emerge as themes within the small body of existing literature and personal …

O Wyodrębnianiu Się Prawa Zmian Klimatu, Monika A. Król

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

W ostatnich trzech dekadach zaważamy wzrost jurydyzacji problematyki odnoszącej się do zmian klimatu zarówno na płaszczyźnie międzynarodowej, unijnej, jak i krajowej. W doktrynie prawa działania na rzecz ochrony klimatu (przeciwdziałania zmianom i adaptacji do zmian klimatu) identyfikowane są dwojako: jako współczesny nurt prawa ochrony środowiska, ale też wyłaniający się już nowy dział – prawo klimatyczne. Przedmiotem artykułu jest analiza poglądów doktryny dotycząca podziału prawa na gałęzie, ewolucji poglądów co do miejsca prawa ochrony środowiska w systemie prawa, a na tym tle podjęcie badań nad stanowiskiem doktryny uzasadniającym wyodrębnienie nowego działu prawa, jakim jest prawo zmian klimatu. Przeprowadzona analiza poglądów doktryny …

Prawo Klimatyczne I Jego Nowe Instrumenty Oddziaływania Na Gospodarkę, Tomasz Bojar-Fijałkowski

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

The European Union has set ambitious environmental climate targets for itself, and thus for its Member States and businesses operating within it. Their implementation requires significant changes in the EU economy. The rapidly developing climate law brings with it new public law instruments to influence entrepreneurs and the economy overall. This article is devoted to an analysis of the evolution of climate law and aims to identify the directions of the development of EU regulation in this area. The objective of the author is to systematise concepts relevant to the legal side of the climate discourse. After characterising the European …

Otoczenie Regulacyjne Jako Czynnik Warunkujący Rozwój I Efektywne Funkcjonowanie Dolin Wodorowych W Polsce, Hanna Spasowska

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

The construction and development of the hydrogen ecosystem may become an important pillar of the transformation of the Polish economy. It will achieve climate neutrality and remain competitive, while taking advantage of the current leading role of the hydrogen producer. These objectives are to be achieved, among others, by hydrogen valleys, which are being created in an increasing number of Polish regions, and, in accordance with the EU hydrogen strategy, are to become an integrated element of the European hydrogen ecosystem. The construction and functioning of the entire ecosystem, with hydrogen valleys as its key elements, must be coordinated at …

Odnawialne Źródła Energii Na Obszarach Wiejskich, Adam Niewiadomski

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

The geographic location of renewable energy sources (RES) is one of the challenges in economic, agricultural and energy law in Poland, as well as in Europe. Rural areas offer the greatest potential for the placement of renewable energy sites, while ensuring their competitiveness on the market. There is a problem, however, in the lack of clear legal regulations enabling the positioning of renewable energy sources in rural areas. This article evaluates selected legal instruments of spatial planning, which are intended to improve the process of RES development. At the same time, the relationship between the use of rural areas for …

Innowacje W Rolnictwie – Agrofotowoltaika, Emilia Nawrotek

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

The aim of the article is to present the principles of the agrophotovoltaics concept (agrivoltaics or APV), and the possibilities of its development in selected countries of the European Union. The adoption of innovations in agriculture is crucial for meeting challenges related to food security, and the goals of sustainable agriculture development. The growing global demand for food and electricity forces the development of photovoltaic agriculture. It is a way to maintain valuable agricultural land, secure food production, and to maintain supply chains without straining the energy system. The introduction of certain legal solutions in EU Member States has brought …

Energy In The Portuguese Climate Framework Law, Rute Saraiva

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

The Portuguese Climate Framework Law of 2021 has been underassessed by legal scholars. Therefore, the purpose of this article is to evaluate it through an energy lens. Through a close analysis of the legal text, the article seeks, firstly, to determine how the climate-energy relationship is treated, and then to understand the challenges that arise in implementing this Law, especially its interaction with the Environmental Policy Basis Law of 2014.

Expression Of Concern: Characterization Of Tfiie-Regulated Genes By Transcriptomeanalysis, Serdar Baysal

Turkish Journal of Biology

Update: This Expression of Concern has been superseded by a Retraction Notice. The Expression of Concern remains part of the permanent publication record. Please see the Retraction Notice and the original article.

The Editors of Turkish Journal of Biology wish to issue an Expression of Concern regarding the article entitled: “Characterization of TFIIE-regulated genes by transcriptome analysis” by Serdar Baysal published on 20.12.2024. Following the publication of this article, concerns have been raised regarding• Potential violations of academic ethical standards in the published study• Potential intellectual property infringement, including plagiarism• An academic sanction reportedly imposed on the author by …

Pneumococcal Colonization Dynamics Among Young Children With And Without Respiratory Symptoms During The First Year Of The Sars-Cov-2 Pandemic., Liset Olarte, Brian R. Lee, Dithi Banerjee, Douglas Swanson, Christopher J. Harrison, Rangaraj Selvarangan

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Non-pharmaceutical interventions to mitigate the spread of SARS-CoV-2 were implemented across the United States in 2020. These public health measures might influence pneumococcal colonization in younger children and their subsequent risk of invasive pneumococcal disease. Our objective was to evaluate pneumococcal colonization rates in children ≤ 5 years of age with and without respiratory symptoms during the first 12 months of SARS-CoV-2 pandemic (April 2020 - March 2021).

STUDY DESIGN: This is a retrospective cross-sectional study evaluating pneumococcal colonization rates, density and serotype distribution across three study periods (April-July [Period 1], August-November [Period 2] and December-March [Period 3]) after …

Butyrylcholinesterase (Bche) Downregulation In Taxane Resistance: Implications For Prostate Cancer, Buse Cevatemre, Arda Işiklar, İpek Bulut, Ezgi̇ Karyemez, Hamzah Syed, Ceyda Açilan

Turkish Journal of Biology

Background/aim: Despite advancements in chemotherapeutic strategies, drug resistance remains a major barrier to effective cancer treatment. While primary prostate cancers (PC) can be treated with surgery and radiotherapy, treatment options for recurrent PC are limited. Upon progression to the castration-resistant (CR) phase, therapies rely on taxanes (chemotherapeutic drugs) like docetaxel (Dtx) and cabazitaxel (Cbz); however, resistance to taxanes is common in CRPC, highlighting the importance of identifying underlying molecular mechanisms or targets in resistant cells.Materials and methods: In transcriptome (RNA sequencing) analyses comparing taxane-resistant PC cells (resistant to both Dtx and Cbz) with parental (nonresistant, sensitive) cells, butyrylcholinesterase (BChE) was …

Novel Mrsa-Targeting Phage Metb16: Genomic Features, Structural Insights, And Therapeutic Applications, Berna Erdoğdu, Senanur Dokuz, Görkem Güngör, Wei Lin, Yigang Tong, Tüli̇n Özbek

Turkish Journal of Biology

Background/aim: Recent reports have indicated that multidrug-resistant strains of S. aureus, including methicillin-resistant strains, may pose a significant threat to public health and global economic stability. Materials and methods: In this study, we present the isolation and comprehensive characterization of a novel phage, derived from clinically isolated MRSA strains. Results: MetB16 exhibited an incubation period of approximately 20 min, a lysis period of around 45 min, and a burst size of 127 Plaque Forming Units (PFU)/cell. The phage demonstrated remarkable biological stability across a pH spectrum of 4.0–9.0 and maintained integrity within a temperature range of 37 and –80 °C. …

Discovery And Characterization Of Selective Lipase-Inhibiting Polyheterocyclic Derivatives: A Combined In Silico And In Vitro Study, Madjda Benguechoua, Mebarka Imane Benguechoua, Khedidja Benarous, Houssem Boulebd, Ibtissem Kadi, Ari̇f Mermer, Yakup Şi̇ri̇n, Alaeddine Kaouka, Mohamed Yousfi

Turkish Journal of Biology

Background/aim: Obesity has become a global health crisis with an increasing prevalence, necessitating the search for effective therapies. Schiff base derivatives, known for their broad pharmacological activities, have gained attention as potential antiobesity agents. This study aimed to investigate the lipase inhibitory potential of novel Schiff base derivatives and assess their drug-like properties through in vitro assays and in silico methods. Materials and methods: The lipase inhibitory activity of synthesized Schiff base derivatives was evaluated using in vitro assays, with IC50 values determined for each compound. Additionally, in silico ADMET predictions (absorption, distribution, metabolism, excretion, and toxicity), molecular docking studies, …

Secondary Youth-Level Mechanisms Of Change In Parent Training For Anxious Youth, Jacey L Anderberg, Kelly Barry, Blake M Upshaw, Katie H Mangen, Samuel D Spencer, Andrew G Guzick, Daphne M Ayton, Amanda D Palo, Abigail E Candelari, Eric A Storch

Faculty, Staff and Students Publications

Background: Parent-focused treatments are a promising approach for addressing youth anxiety outside of traditional therapist-delivered modalities. Supportive Parenting for Anxious Childhood Emotions (SPACE) has preliminarily demonstrated efficacy for reducing family accommodation (FA), a key treatment outcome for youth anxiety.

Objective: Since the mechanisms of SPACE remain relatively understudied, we examined youth-reported distress tolerance (DT), anxiety sensitivity (AS), and negative automatic thoughts as candidate mechanisms of SPACE using data from a previously conducted clinical trial.

Methods: In a sample of N = 68 youth (M age = 10.2; 52% male; 62% White), we examined: (a) associations among candidate mechanisms and …