Digital Commons Network^™

Antiinflammatory Effects Of Cucurbitacins And Sorafenib In Hepg2 Cells By Modulating The Iκb/Nf-Κb/Cox-2 Pathway Through Akt Signaling, Muhammed Mehdi̇ Üremi̇ş, Yusuf Türköz, Nuray Üremi̇ş

Turkish Journal of Biology

Aim: Cucurbitacins possess antitumor, antiproliferative, and antiinflammatory properties. This study aims to examine the antiinflammatory effects of CuD, CuI, and CuE on NF-κB, iNOS, COX-2, and Akt and compare their cytotoxic and antiinflammatory effects on HepG2 cells with sorafenib, the primary chemotherapeutic agent used in HCC treatment. Methods: Cytotoxic effects of cucurbitacins and sorafenib on HepG2 cells were evaluated using MTT and LDH assays, along with Annexin V, MMP, and comet assays. Levels of proteins related to the Akt/NF-κB pathway and COX-2, iNOS, and NO were also measured. Results: Our study showed that CuD, CuI, CuE, and sorafenib have antiproliferative …

Associations Between Daytime Sleepiness, Obesity, And Sleep Apnea Severity Among Caribbean Women, Melaine F. Mcleod

Walden Dissertations and Doctoral Studies

Obstructive sleep apnea is the most common type of sleep-disordered breathing. Obstructive sleep apnea (OSA) is a global health epidemic that is associated with the obesity pandemic and daytime sleepiness. This quantitative cross-sectional descriptive study aimed to examine associations between daytime sleepiness measured by the Epworth Sleepiness Scale, obesity measured by body mass index (BMI), and severity of OSA measured by the apnea-hypopnea index among Caribbean women residing in the Cayman Islands. The health belief model served as the theoretical framework to guide this research. Daytime sleepiness and obesity were independent variables; the dependent variable was the severity of OSA, …

Contrast Enhancement, G-Cimp Subtype, And Cdkn2a/B Homozygous Deletion In Idh-Mutant Astrocytoma, Mehak Majid Khan, Wenyin Shi, Iyad Alnahhas

Department of Neurology Faculty Papers

No abstract provided.

Topical Application Of Exosomes In A Patient With Acne Conglobata: A Case Report, Theressia Handayani, Stefani Luziani

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Acne conglobata (AC) is a rare and severe acne characterized by interconnected nodules, cysts, and abscesses. Mesenchymal stem cell-derived exosomes (MSC-exosomes) have immunosuppressive properties that alleviate inflammation and immunological reactions. We present a case of AC in a patient who received topical administration of exosomes.

Case Illustration: A 20-year-old male was diagnosed with AC, presenting as inflammatory papules and cysts covered with yellowish crusts that had been present for five months. Exosomes (ASCE+®, Seoul, South Korea) were topically administered at a dose of 5 mL, applied evenly to the face. The patient underwent three treatment sessions, with a …

Herpes Zoster Reactivation Following Covid-19 Mrna Vaccination In An Elderly Patient: A Case Report, Ratu Siti Khadijah Sarah, Yari Castiliani Hapsari, Shannaz Nadia Yusharyahya, Eliza Miranda, Sarah Qanita Edwar

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Latent varicella-zoster virus (VZV) in nerve ganglia may reactivate into herpes zoster infection. The coronavirus disease (COVID-19) vaccine is suspected of triggering VZV reactivation, although the exact cause is unclear. This case report aims to raise awareness of the potential complications induced by the COVID-19 mRNA vaccine, particularly in elderly patients.

Case Illustration: A 62-year-old woman complained of itchy and painful unilateral dermatomal herpetiform blisters six days after mRNA COVID-19 vaccination. The vesicle first appeared on the left breast, spreading to the back. The patient has a history of hypertension. After the administration of 800 mg of acyclovir five …

Serial Excision Of A Nevus Sebaceous Of Jadassohn On The Scalp, Belladikna Brillianty Sugiatno, Arif Widiatmoko, Adinda Amalia Dani, Diah Prabawati Retnani

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Nevus sebaceous of Jadassohn (NSJ) is a non-hereditary hamartoma of the skin’s adnexal structures. The incidence of NSJ in newborns is estimated at 0.1-0.3% with no gender or ethnic propensity. Surgical excision is a common treatment for NSJ, although there is no definite consensus on the timing or recommendations for the removal. This article aims to present the advantages of serial excision therapy in a case of NSJ.

Case Illustration: A 14-year-old male presented with a complaint of a bump on the scalp since birth, which had progressively enlarged during puberty. Dermatological examination revealed a well-demarcated, yellow-orange …

Validity And Reliability Of The Indonesian Version Of Nordic Occupational Skin Questionnaire 2002 (Nosq-2002), Listya Paramita, Fajar Waskito, Dikky Prawiratama, Niken Indrastuti, Tuntas Rayinda, Sri Awalia Febriana

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Epidemiological data on occupational hand eczema in Indonesia is still limited, partly because there are no valid and reliable instruments in the Indonesian language as a means of survey. This study aims to translate the Nordic Occupational Skin Questionnaire 2002 (NOSQ-2002) into the Indonesian language and assess the validity and reliability of the Indonesian NOSQ-2002 as an instrument for epidemiological surveys and screening of occupational hand eczema.

Methods: The original English version of NOSQ-2002 was translated into the Indonesian language following the standard procedure of translation. The Indonesian NOSQ-2002 version, which had been collectively approved, was subsequently completed by …

The Epidemiology Of Sports And Recreation Related Toe Fractures In The United States, Dogerno Norceide, Gabriel I. Onor, Oluwatomi Akingbola, William Justice, Nana F. Amponsah, Abimbola Okulaja, Ifeanyichukwu Onor, Michael Okoronkwo, Chibuikem Nwizu, David Pedowitz, Md

Rothman Institute Papers

BACKGROUND: Fractures of the toes are among the most frequently diagnosed lower extremity fractures. In sports, toe fractures may present after diverse mechanisms of injury, varying severity, and varying implications for management. This study aimed to discern trends in toe fractures presenting to US emergency departments (EDs) particularly in association with sports and recreational activities. An additional aim of the study was to identify if rates of toe fracture presentation significantly decreased during the year 2020 at the height of the COVID-19 pandemic.

METHODS: We queried the National Electronic Injury Surveillance System (NEISS) database to identify toe fractures presented to …

Documenting Our Success Stories: Merits Of Case Reporting In Homoeopathic Research And Practice, Subhash Kaushik

Indian Journal of Research in Homoeopathy

Editorial

Segmental Vitiligo Treated By Homoeopathic Constitutional Medicine Tuberculinum: An Evidence-Based Case Report, Shubham Grover, Ashwini Nair

Indian Journal of Research in Homoeopathy

Introduction: Vitiligo is characterised by a patchy loss of skin pigmentation, which most commonly occurs due to the immune system targeting melanocytes in the epidermis. A few studies have shown the effectiveness of Homoeopathy in halting the progression and replacing the hypo-pigmented patches with normal-pigmented skin. Case Summary: A 15-year-old boy came to the clinic complaining of white patches that appeared suddenly on various parts of his body within one week. Tuberculinum proved to be the constitutional medicine in this case. The photographic evidence taken at regular intervals and a follow-up of over nine months showed the potential of constitutional …

Management Of Leiomyoma And Ovarian Cyst With Homoeopathic Medicine Thuja Occidentalis: An Evidence-Based Case Report, Bharti Wadhwa, Sujata Madhukar, Shweta Singh Kureel

Indian Journal of Research in Homoeopathy

Introduction: Leiomyoma (Uterine Fibroid [UF]) is the most prevalent benign solid tumour arising from the neoplastic transformation of smooth muscle cells of myometrium in the reproductive age of females. Fibroids are rare before puberty, increase in prevalence during the reproductive years, and usually reduce in size after menopause.

Case Summary: A 34-year-old woman presented with a complaint of hypogastric pain, and heavy bleeding during her menstrual periods since 3–4 months. Her menstrual cycle was irregular. She was diagnosed with an intramural UF and a right ovarian cyst on ultrasonography. Thuja occidentalis (in different potencies) was prescribed based on …

Role Of Individualised Homoeopathic Treatment In A Case Of Secondary Infertility With Uterine Fibroid Treated Through Psychosomatic Approach: A Case Report, Neha Swarup, Mahesh Gupta, Maneesh Mishra, Sanjay Gupta

Indian Journal of Research in Homoeopathy

Introduction: Infertility is the inability of a couple to conceive even after being sexually active for a period of one year. It is a fact that the inability to have one’s own child is a grave concern worldwide. Infertility is a globally prevalent condition, with 8–12% of the world population suffering from it. Infertility in females can be due to several causes, one of them is a uterine anomaly like uterine fibroid. Uterine fibroids are generally considered a structural pathology and mostly managed as a surgical condition. A vast literature review emphasises the importance of psychological factors which can lead …

Uterine Fibroid And Haemorrhagic Ovarian Cyst Treated With Homoeopathic Medicine Sepia Officinalis In Lm Potency: An Evidence-Based Case Report, Karunakara Moorthi, K. R. Siva Tharshini

Indian Journal of Research in Homoeopathy

Introduction: Uterine fibroids are the most common benign neoplasms of the female genital tract in reproductive-age women. The wide range of symptoms includes menorrhagia, metrorrhagia, continuous/post-menopausal bleeding, pain and pressure symptoms. The haemorrhagic ovarian cyst is an adnexal mass which resolves spontaneously by itself but requires surgery if it is more than 5 cm in size. Case Summary: A 46-year-old female patient came to the outpatient department with profuse uterine bleeding during menses lasting approximately 8–10 days and cutting pain in the lower abdomen extending to the back for two years. Magnetic resonance imaging studies showed a uterine fibroid along …

Cognitive Defense: 2024 Homeland Defense Symposium

Books, Monographs & Collaborative Studies

©2025 Mark R. Landahl – Chapter 1

©2025 George M. Schwartz – Chapter 3

The US Army War College hosted the inaugural annual Homeland Defense Symposium from February 6 to 8, 2024, at Carlisle Barracks, Pennsylvania. The conference, entitled “Reestablishing the Sanctuary,” featured plenary presentations on defending critical infrastructure, contested deployment, and cognitive defense by experts from military, academic, and government organizations.

As highlighted in the conference theme, attendees recognized the homeland does not provide the sanctuary it once did, and our society is already under attack. Using disinformation and social media means, our adversaries are engaged in cognitive warfare …

Emergence Of Caenocoris Neri (Germar, 1847) On Fig Trees In The Oases Of Southeastern Algeria, Nacima Diab, Tesnim Deghiche, Khalila Bengouga, Vasily Vladimirovich Verkhoturov

Journal of Bioresource Management

The article considers materials related to current areas of fundamental research in the field of agricultural entomology in Algeria. The most important issues of agricultural entomology in Algeria include identifying patterns of general trends in the dynamics of geographic ranges of phyto-entomophagous under the influence of climatic and anthropogenic factors, as well as studying the adaptation of insects to new habitats and food supply. In a notable discovery during insect sampling conducted in the oasis ecosystem during the summer of 2019, researchers recorded and identified individuals of the species Caenocoris nerii (Germar, 1847) for the first time. These insects were …

Social Communication Implementable And Applicable Lens: A Framework For Addressing Assessment Of Social Communication, Louise C. Keegan, Jerry K. Hoepner, Leanne Togher, Mary Kennedy, Elise Bogart, Melissa Brunner, Sheila Macdonald

Communication Sciences and Disorders Faculty Articles and Research

Purpose:

Method:

Comparing Sodium Fusidate And Petrolatum For Electrosurgery-Related Wound Healing: A Double-Blind Randomized Controlled Trial, Firman Parrol, Larisa Paramitha Wibawa, Irma Bernadette Simbolon Sitohang, Siti Rizny Fitriana Saldi

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Electrosurgery is a common surgical technique used to treat skin tumors. This procedure produces necrotic skin, which might impair the wound healing process, prompting physicians to prescribe topical antibiotics to prevent infection. This study aims to analyze the efficacy of sodium fusidate ointment compared to petrolatum for wound healing after electrosurgery.

Methods: We conducted a double-blind, randomized, controlled study with a within-person design. The inclusion criteria were adult subjects with seborrheic keratosis or acrochordon with a size of 4 mm to 10 mm on the face and neck, with a minimum of 2 lesions. Electrodessication was performed on the …

Combination Of 1064 Nm Qs Nd:Yag Photoacoustic Technology And Exosome For Facial Rejuvenation, Stanley Setiawan, Samuel Septrian Putranto, Angela Maria Linata, Stephanie Salim, Novia Sari Andriati Mertosono, Shelly Nobel, Flora Asri Wardianti, Ita Anggraini, Zulaikha Rizqina Rahmawati

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Facial rejuvenation has become a global trend in cosmetic and aesthetic dermatology to restore youthful skin. The combination of 1064 nm Q-Switched Neodymium:Yttrium Aluminum Garnet (QS Nd:YAG) laser and exosomes as a facial rejuvenation procedure restores youthfulness by increasing collagen and elastin.

Case Illustration: This case series evaluated the effectiveness of 1064 nm QS Nd:YAG laser with and without human amniotic fluid stem cell-derived exosomes (hAFSC-exo) for facial rejuvenation in six adults aged 24–39 years with Fitzpatrick skin types III-IV. Participants were randomized to receive either laser treatment alone or combined with intradermal hAFSC-exo injections every two weeks for …

Skin Rejuvenation With Microbotox: A Review, Ifen Ayu Malinda, Nelva Karmila Jusuf

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Skin aging is characterized by a gradual loss of tissue and organ function. Skin aging can be classified into two types: intrinsic aging, associated with the aging process itself, and extrinsic aging, which is linked to external factors. Microbotox—an intradermal injection of diluted botulinum toxin—has emerged as a promising technique for rejuvenation by improving skin texture, pore size, and sebum control. This review aims to provide a comprehensive overview of the microbotox technique in the context of skin aging, emphasizing its mechanisms, indications, and clinical outcomes.

Discussion: In Asia, intradermal injection of botulinum toxin or microbotox has been widely …

Cybersecurity Strategies For Effective Proactive Response To Cyber Attacks, Tony L. Perry

Walden Dissertations and Doctoral Studies

Malicious cybersecurity attacks threaten the confidentiality, integrity, and availability of organizational data. This issue concerns organizational leaders and cybersecurity professionals who must address these threats to prevent operational disruptions, financial losses, reputational damage, and declining stakeholder trust. Grounded in organizational learning theory, the purpose of this qualitative pragmatic inquiry was to explore the strategies information technology security professionals use to proactively respond to evolving cybersecurity threats. The study involved 16 cybersecurity professionals, each with a minimum of five years of experience in implementing both offensive and defensive cybersecurity strategies within their organizations. Data were collected through semistructured interviews and a …

Cultural And Structural Barriers Influencing The Mental-Health-Seeking Behaviors Of South Asians In Dallas, Texas, Judith Jose

Walden Dissertations and Doctoral Studies

Despite being one of the fastest growing immigrant populations in the United States, South Asians experience disproportionately high rates of untreated mental health conditions while reporting low utilization of professional mental health services. This qualitative phenomenological study explored the cultural and structural barriers that influence mental-health-seeking behaviors among South Asians residing in Dallas, Texas. Guided by the health belief model and principles of cultural competency, this research investigated how perceived susceptibility, severity, benefits, barriers, cues to action, and self-efficacy intersect with cultural stigma, religious beliefs, generational dynamics, and systemic obstacles. Semistructured interviews with 12 South Asian adults revealed seven major …

Technology Manufacturing Organizations’ Strategies For Achieving Sustainability, Kate Cheney

Walden Dissertations and Doctoral Studies

Sustainability remains a challenge for technology manufacturers struggling to integrate environmental priorities into core operations. This issue is critical for technology manufacturing managers who must embed sustainability into organizational systems and decision-making processes to meet rising expectations from regulators, investors, and consumers. Grounded in transformational leadership theory, the purpose of this qualitative pragmatic inquiry study is to identify and explore effective strategies used by technology manufacturing managers in the western region of the United States. The data collected from seven semistructured interviews were analyzed using thematic analysis. The five themes that emerged were (a) leadership and company culture, (b) collaboration, …

Provision Of Transportation To Psychiatric Follow-Up Appointments, Eliane Sandrine Tueche Fankam

Walden Dissertations and Doctoral Studies

This quality improvement initiative is focused on the lack of transportation as a significant barrier to obtaining health care services for patients with severe psychiatric disorders. Transportation issues remain an important factor that hinders the attainment of health care services by the members of this population. Transportation challenges should be addressed as much as possible for improving healthcare accessibility and providing timely care. Prior to the implementation of the transportation service, only 30% of patients with severe mental illness (SMI) attended their scheduled appointments, demonstrating the need for intervention. This project focused on whether providing transportation services would improve compliance …

Non-Profit Mental Health Organization: Overcoming Employee Turnover With Retention Strategies, Navpreet Brar

Walden Dissertations and Doctoral Studies

This professional administrative study explored the root causes of employee turnover at a nonprofit mental health organization, where turnover had reduced treatment consistency, increased emotional distress among clients, and decreased staff morale. The purpose of this study was designed to develop effective strategies to enhance retention, improve employee engagement, and support high-quality patient care through an application of the social exchange theory. The study addressed four practice-focused questions: (a) What are the underlying causes of turnover at this organization? (b) How can effective strategies be developed and implemented to reduce turnover? (c) How can the organization enhance employee engagement to …

Tariffs & Export Expansion, Ishrat Husain Dr.

Faculty Research - Newspaper and Magazine Articles

No country has achieved prosperity by relying solely on its domestic markets. The spectacular success of China, despite having a large market of 1.4 billion people, is primarily attributed to its integration into the world economy. In merely three decades, China has become the top exporting nation.

20250626: College Of Science, 1975-2002, College Of Science

Guides to University Archives

These items include materials from the College of Science at Marshall University from 1975-2002. Items were received in 2025 from the Dean of College of Science, Dr. Wesley Stites. This collection includes notable materials from or about the history of of the Science Building and its renovations. Also included is the project manual for the RCB Biotechnology Center.This is not an exhaustive list. Please download the finding aid for a full list of contents

Maternal And Child Nutrition: Nutrition And Weight Management In Pregnancy, And Nutrition In Children Up To 5 Years-Summary Of New Nice Guidance, Shalmali Deshpande, Samantha Ross, Sharangini Rajesh, Maija Kallioninen, Kate Maslin

School of Nursing and Midwifery

No abstract provided.

Mediating Roles Of Corneal Biomechanical And Topographic Parameters In Eye Rubbing And Keratoconus Based On The Chinese Keratoconus Cohort Study, Kaili Yang, Runqi Tu, Liyan Xu, Yuwei Gu, Qi Fan, Shanshan Yin, Yi Yuan, Anqi Chang, Yifan Wang, Chenchen Yin, Yonghao Zang, Chenjiu Pang, Daniela Oehring, Yibin Hao, Shengwei Ren

School of Health Professions

Purpose: Studies have shown that eye rubbing is associated with increased risk of keratoconus (KC). However, the potential mediating roles between eye rubbing and KC remain largely unknown. Hence, this study aims to explore the mediating roles of two specific factors, namely, the inverse of the stiffness parameter at the first applanation (-SPA1) and maximal corneal keratometry (Kmax) values, in the relationship between eye rubbing and KC. Methods: A total of 395 patients with KC and 396 controls from the Chinese keratoconus (CKC) cohort study were included in this case–control analysis. The Spearman correlation and generalized linear regression models were …

Physical Activity And Functional Mobility In Adults With Hearing Loss: A Series Of Embedded Studies Within A 6-Month Clinical Trial With Hearing Aids, Sarah L. Bochat

USF Tampa Graduate Theses and Dissertations

Adults with hearing loss engage in low levels of physical activity and demonstrate poor performance on measures of functional mobility. The impact of hearing rehabilitation on these outcomes is not fully understood. Previous investigations were largely quantitative and focused on older adults ≥ 65 years of age who may respond differently to hearing intervention than relatively younger adults. They also tended to focus on exercise rather than global engagement in physical activities and did not report hours of hearing aid use, an important indicator of intervention success. One purpose of this dissertation was to determine the feasibility of collecting accelerometry-assessed …

Room-Temperature Multiferroic Epsilon Iron Oxide Semiconductors: Thin-Film Growth And Characterization, Derick Detellem

USF Tampa Graduate Theses and Dissertations

There is an ever-growing need for larger computing power, nonvolatile memory and energy efficient devices as the number of applications that draw upon the current base of computer resources increases. At the forefront of research aiming to meet this need is the field of multiferroics. If it is possible to leverage the fast and energy efficient application of an electric field with the data storage capabilities of magnetic materials, then it would be possible to not only increase the robustness and energy efficiency of current memory, but possibly present new types of device components for computation application as well. Currently, …