Digital Commons Network^™

A Case Study In Evolving Academic Governance: Democratic Accountability And Academic Capitalism, William C. Schulz, Denise Dezolt

Higher Learning Research Communications

As the higher education market becomes both more competitive and fragmented (as well as controlled through uncertain and changing regulatory regimes), and as those whom the higher education market serves become more discerning as consumers who apply proven customer behaviors within the market, universities must re-evaluate their internal governance systems. Re-evaluation of customer behaviors and governance systems may allow universities to become more inclusive, responsive, and adaptive within an academic capitalism setting.

In this case study, we present a research-based and integrated “Shared, Informed, Stakeholder-Engaged Governance” model. We describe how a large online university developed and implemented a model that …

Optimization Of Participation Path Of Trade Union Organizations In Social Co-Governance Of Food Safety, Xu Chaofan

Food and Machinery

In the context of China's social co -governance of food safety,advancing the participation of trade union organizations plays a significant role in enhancing workers' professional quality through education and training,and strengthening corporate responsibility through collective bargaining.Although notable progress has been made in current practices,challenges still exist,including the relatively simple form of popular science education,the insufficient effectiveness of new media publicity,and the inadequate support for workers' food safety reporting by trade union organizations.To address these challenges,solutions should be explored from multiple perspectives:diversifying public science education methods,forming a full -media publicity strategy for trade unions in food safety co -governance,and improving support …

Preparation And Structural Analysis Of Antioxidant Peptides From Tilapia Skin By Microwave-Assisted Enzymatic Hydrolysis, Mi Chunxiao, Zhou Hui, Hu Xingyuan, Zhu Wanting, Wu Long

Food and Machinery

［Objective］ To prepare antioxidant peptides from tilapia skin by microwave -assisted enzymatic hydrolysis and conduct structural analysis.［Methods］ The processing conditions for preparing antioxidant peptides by microwave pretreatment -assisted alkaline protease hydrolysis are optimized through single -factor and response surface experiments,and the effects of microwave treatment on the structure of fish skin,the relative molecular weight,amino acid composition,and antioxidant activity of antioxidant peptides are analyzed.［Results］］ The optimal processing conditions for preparing antioxidant peptides by microwave -assisted enzymatic hydrolysis are as follows:microwave power of 441.50 W,microwave temperature of 61.00 ℃,microwave time of 20 min,hydrolysis time of 6.21 h,enzyme dosage of 2.20%,and solid -to-liquid …

Robust Embeddings Of Genetics, Anatomy, And State Decoded From A Neuron’S Activity, Aidan Schneider

Arts & Sciences Graduate Student Theses and Dissertations

Neural spike trains are shaped by both extrinsic inputs and intrinsic structural constraints. While prior work has focused on how spike timing encodes externally driven variables, such as stimuli or behavior, this dissertation explores whether principles that organize neural activity in space and time—such as genetic cell type, anatomical location, and arousal state—are also embedded in the spiking output of individual neurons. I hypothesize that these organizing principles are not quenched as irrelevant variability, but rather multiplexed within the neural code itself. To test this, I attempt to decode these principles from the spike trains of neurons recorded in behaving …

External Challenges For Individuals Who Need Or Use Aac Who Are Learning Language: Lived Experiences, Key Research Findings, And Future Directions, Christine Holyfield, Janice Light, Dana Nieder, Jamie Preece

Communication Disorders and Occupational Therapy Faculty Publications and Presentations

Language skills are essential to effective communication, but learning language is by no means a simple process for individuals with developmental disabilities who cannot rely on speech alone to be heard and understood. Research demonstrates that augmentative and alternative communication (AAC) interventions positively impact development across language domains (e.g., pragmatics, semantics, morphosyntax) and may also benefit speech production. However, these gains can only be realized if people have timely access to effective AAC and have meaningful opportunities to interact with others. This paper integrates the lived experiences of individuals who need or use AAC and their families with key research …

Ptpn11 Mutations Define A Rare But Highly Adverse Subset Of Myelodysplastic Syndromes, Alexandre Bazinet, Alex Bataller, Guillermo Montalban-Bravo, Kelly Chien, Koji Sasaki, Wei Ying Jen, Mahesh Swaminathan, Tapan Kadia, Courtney Dinardo, Farhad Ravandi, Guillermo Garcia-Manero, Hagop Kantarjian

Faculty, Staff and Student Publications

No abstract provided.

Restoring P53 Wild-Type Conformation In Tp53-Y220c-Mutant Acute Myeloid Leukemia, Bing Z Carter, Po Yee Mak, Edward Ayoub, Xiaogang Wu, Baozhen Ke, Yuki Nishida, Andrew Futreal, Lauren B Ostermann, Andrea D Bedoy, Steffen Boettcher, Courtney D Dinardo, Anna Puzio-Kuter, Masha V Poyurovsky, Arnold J Levine, Michael Andreeff

Faculty, Staff and Student Publications

TP53-Y220C is a recurrent hotspot mutation in cancers and leukemias. It is observed predominantly in acute myeloid leukemia (AML)/myelodysplastic syndromes among hematological malignancies and is associated with poor outcome. The mutation creates a structural pocket in the p53 protein. PC14586 (rezatapopt) is a small molecule designed to bind to this pocket and thus restore a p53-wild type (p53-WT) conformation. We demonstrate that PC14586 converts p53-Y220C into a p53-WT conformation and activates p53 transcriptional targets, but surprisingly induces limited/no apoptosis in TP53-Y220C AML. Mechanistically, MDM2 induced by PC14586-activated conformational p53-WT and the nuclear exporter XPO1 reduce the transcriptional activities of p53, …

Hallmarks Of Stem Cell Aging, Thomas A Rando, Anne Brunet, Margaret A Goodell

Faculty, Staff and Students Publications

As organisms age, somatic stem cells progressively lose their ability to sustain tissue homeostasis and support regeneration. Although stem cells are relatively shielded from some cellular aging mechanisms compared with their differentiated progeny, they remain vulnerable to both intrinsic and extrinsic stressors. In this review, we delineate five cardinal features that characterize aged stem cells and examine how these alterations underlie functional decline across well-studied stem cell compartments. These hallmarks not only provide insight into the aging process but also serve as promising targets for therapeutic strategies aimed at rejuvenating stem cell function and extending tissue health span.

Testosterone Deficiency And Treatments: Common Misconceptions And Practical Guidance For Patient Care, Mohit Khera, James M Hotaling, Martin Miner

Faculty, Staff and Students Publications

Introduction: Misconceptions about testosterone therapy are prevalent and there is an unmet need for a review of current literature that can be leveraged by physicians to deliver safe and effective care for men with hypogonadism.

Objectives: This review aims to address common misconceptions about testosterone therapy using current literature and synthesize practical guidance for clinicians with patients who are starting testosterone therapy.

Methods: A literature search of PubMed, Embase, CINAHL was carried out to identify associations between testosterone therapy and prostate cancer, cardiovascular risk, and hepatic toxicity; definitions of hypogonadism; and practical guidance for clinician with patients starting testosterone therapy. …

Factors Related To Hypertension In Pediatric Patients Who Do Not Have Obstructive Sleep Apnea: A Retrospective Chart Study, Alyssa Exarchakis, Alexandra Cohen, Penghao Wang, Seema Rani, Diana Martinez

Department of Medicine Faculty Papers

Background/Objectives: The relationship between OSA and adult hypertension has been extensively studied; however, it remains understudied in pediatric patients without OSA. The aim of this study is to identify factors associated with pediatric hypertension without OSA, through an IRB-approved retrospective chart review of patients who underwent polysomnography at Nemours Children's Hospital, DE/NJ between January 2020 and July 2023. Methods: Eligibility criteria included children 8-17 years, completed PSG, and clinic visit blood pressure (BP). Anthropometrics, demographics, social determinants, and medical history were obtained from electronic medical records. Hypertension was defined as the average systolic and/or diastolic BP that is …

Quantum Magnetization Exchange Through Transient Hydrogen Bond Matrix Defines Magnetic Resonance Signal Relaxation And Anisotropy In Central Nervous System, Dmitriy A Yablonskiy, Alexander L Sukstanskii

2020-Current year OA Pubs

The integrity of cellular membranes (lipid bilayers) and myelin sheaths covering axons is a crucial feature controlling normal brain structural and functional networks. Yet, in vivo evaluation of this integrity at the nanoscale level of the cellular membranes organization is challenging. Herein we explore the dual property of biological water in Central Nervous System (CNS), as one of the major stabilizing factors of cellular membranes, and the major source of MRI signal. We introduce the Basic Transient Hydrogen Bond (THB) model of the MR signal relaxation due to the quantum spin/magnetization exchanges within the THB Matrix encompassing water molecules and …

Characteristics Of Hospitals Participating In The Transforming Episode Accountability Model, Sukruth A Shashikumar, Jie Zheng, Thomas C Tsai, E John Orav, Arnold M Epstein, Karen E Joynt Maddox

2020-Current year OA Pubs

No abstract provided.

The Trapping Of Live Neutrophils By Macrophages During Infection, Kelley N Cooper, Marina Terekhova, Barbara Potempa, Ana D'Aubeterre, Jerome Timbol, Si An Chen, Antoine Dufour, Shunying Jin, Maxim N Artyomov, Jan Potempa, Juhi Bagaitkar

2020-Current year OA Pubs

Neutrophils are highly abundant in the oral mucosal tissues, and their balanced activation and clearance are essential for immune homeostasis. Here, we demonstrate that neutrophils infected with the bacterial pathogen Porphyromonas gingivalis (Pg) are captured alive by macrophages in a manner that bypasses all known receptor-ligand interactions involved in the phagocytosis of either live or dead cells. Mechanistically, upon interaction with Pg, or its protease RgpB (gingipains), live neutrophils undergo rapid remodeling of their proteomes, generating neoepitopes. N-terminomics-based proteomic profiling identified multiple RgpB cleavage sites on several azurophilic granule proteins that are translocated to the surface of live neutrophils via …

Atrial Fibrillation Or Flutter In Patients Undergoing Stem Cell Transplantation, In-Hospital And Post-Discharge Outcomes In A Large Nationwide Sample Across The United States, Raja Zaghlol, Elena Deych, Nina Manian, Ahmed Altibi, Joshua D Mitchell

2020-Current year OA Pubs

BACKGROUND: Stem Cell Transplantation (SCT) is a cornerstone therapy in managing several malignant and benign hematological conditions. Atrial fibrillation/atrial flutter (AF) are commonly encountered in patients receiving SCT. There is a paucity of large-scale data on the prevalence of AF and their effect on outcomes following SCT.

METHODS: The United States National Readmission Database (NRD) was used to identify hospitalized patients who underwent SCT. Baseline demographics, comorbidities, the presence or absence of AF, the indication, and type of SCT were identified using diagnostic and procedural International Classification of Diseases 10th Edition (ICD-10) codes. Patients with AF were compared to those …

Atrial Fibrillation Is Associated With Increased In-Hospitality Mortality During Chimeric Antigen Receptor T-Cell Therapy Hospitalizations: A Retrospective Cohort Study In The United States, Nischit Baral, Nabin R Karki, Daniel A Ladin, Raja Zaghlol, Mahmoud Ibrahim, Alexander Rabadi, Tarec K Elajami, Olivia Mechanic, Arvind Kunadi, Joshua D Mitchell

2020-Current year OA Pubs

BACKGROUND: Chimeric Antigen Receptor (CAR) T-cell therapy (CAR-T) has emerged as a promising treatment for specific hematological malignancies. While some studies suggest an association between CAR-T and atrial fibrillation (AF), more data are needed on the association of AF with CAR-T outcomes.

METHODS: This retrospective cohort study utilized the National Inpatient Sample (NIS) 2017-2020 to explore in-hospital outcomes in cancer patients with AF while undergoing CAR-T. Comparisons were drawn between patients with and without AF during the hospitalization, assessing various parameters including mortality rates, length of hospital stay, and occurrences of acute heart failure, pulmonary edema, and gastrointestinal (GI) bleeding. …

Squash Bug Integrated Pest Management, Nick Volesky, Marion Murray

All Current Publications

This infographic reviews integrated pest management for squash bugs. It includes information on the following: resistant varieties of vegetables to plant and crop rotation, homemade traps, mechanical destruction, mulches, trap crops, natural enemies, and organic and synthetic insecticides.

Developing Affirmative Housing And Building Community For Older Lgbtq+ Adults In Spokane, Washington, Katie Diane Miller

2025 Symposium

This qualitative, exploratory study seeks to propose potential community interventions that will increase access to inclusive housing and decrease social isolation among LGBTQ+ individuals over 50 years of age based on currently available data. Social isolation has been recognized as a public health issue widely impacting communities across the United States. The older LGBTQ+ population is especially impacted by social isolation because of systemic discrimination and limitations. LGBTQ+ older adults in the US have historically faced a lack of legal protections, gaps in healthcare access, and structural and interpersonal inequity because of system development that support binary beliefs. These factors …

Satellites For Development, Broadcasting And Information

Communication Research Trends

The symbol of the 'global village' is the communications satellite. For over twenty years, ever since the. USSR launched Sputnik in 1957, the USA and the USSR in particular, and other countries too, have been devoting ever more financial and human resources to the building of ever more elaborate satellite systems; Today a host of communication satellites are positioned in geostationary orbit 22,282 miles (35,860 kilometres) above the equator. The globe is encircled by a communications network that links the most distant parts of the earth in a matter of seconds.

A communications satellite system consists of three parts. The …

Gaining Insights Into Community Engagement Efforts: Learning From Preservice Stem Educators, Amy G. Maples, Lynn L. Hodge, Nick Kim

Journal of Community Engagement and Higher Education

This study seeks to extend research in the field by exploring literature examining preservice teachers’ perceptions of community engagement efforts. We then report findings from a thematic analysis of a survey conducted with teacher candidates at a university in the southeastern U.S. who took part in school- and community-based STEM events, and provide implications and suggestions for utilizing community engagement opportunities as a means of enriching preservice teachers’ understandings of local school and community contexts.

This Is Why We Do It: Faculty Motivations For Embracing Community-Engaged Pedagogy, Magdalena Denham, Lee M. Miller, Joyce K. Mccauley, Danica Schieber, Taylor L. Morrison, Chuck Drumm

Journal of Community Engagement and Higher Education

Institutions of higher education are increasingly highlighting community engagement activities to make the benefits of higher education more visible. The most transformational community engagement is linked to curriculum, so it is faculty who must incorporate community-engaged pedagogy. This content analysis of faculty narratives about community engagement reveals motivations for faculty to engage in this work. These findings connect to social capital theory and suggest a new direction for faculty development efforts to promote community engagement.

The Role Of Cultural Brokers In Community-Based Research, Rachel Boit, Joy Birabwa, Dhoha Altaki, Savannah Bayer, Michele Kamau, Linda Hestenes

Journal of Community Engagement and Higher Education

Cultural brokers play a critical role of helping researchers navigate cultural and language barriers to gain insight into communities. This paper focuses on one cultural broker who helped facilitate community-based research among the refugee community. Her professionalism, expertise and knowledge of the community made her a valuable resource for both the researchers and the community. This work acknowledges the position of power and privilege that cultural brokers hold in community research.

Town And Gown: Engagement And Collaboration Between Local Municipalities And Institutions Of Higher Education, Vivian González Cueto

Journal of Community Engagement and Higher Education

The role of the local government within the context of engagement and collaboration with universities has largely been understudied. Employing a cross-sectional design, this study of 67 universities and 78 municipalities from 29 states examines how collaborative capacity impacts university and local government perceptions of engagement and collaboration with each other. The findings indicate that local government trust is the primary catalyst for both engagement and collaboration between the parties.

Community Engagement In Music Therapy: Reflections From The Field, Jess Rushing, Denise M. Cumberland

Journal of Community Engagement and Higher Education

This paper reflects on a music therapy community engagement project that incorporates clinical training, service learning, and community music therapy. Two faculty members and a practicum student in a Midwestern university engaged community members connected to Parkinson’s disease to create a music-based program. We offer a conceptual framework that connects approaches situated within community music therapy (CoMT) qualities and community-based participatory research (CBPR) principles. We share project processes, findings, and recommendations, emphasizing all as equal stakeholders.

Modeling, Analysis, And Prediction Of Covid-19 Dynamics With Interacting Subpopulations And Implicit Behavior Using Physics-Informed Neural Networks, Naima Aubry-Romero, Alonso Ogueda-Oliva, Padmanabhan Seshaiyer

Spora: A Journal of Biomathematics

In this paper, we consider an extended SEIR compartmental model that incorporates young and old interacting subpopulations, allowing for cross-group transmission dynamics. Implicit behavioral changes are included to determine the influence of social behavior on coronavirus transmission dynamics. The basic reproduction number, the average number of secondary cases of infection produced by a single primary case, is derived for both the explicit and implicit model using the next-generation matrix method. We solve the associated differential equation systems and estimate useful parameters in the explicit model using physics-informed neural networks (PINNs). Our results point to how the PINNs approach offers an …

Book Publishing In A Changing Environment

Communication Research Trends

In 1982 Unesco held the first World Congress of Books in London. Its aim was to promote the idea of the 'reading society'. As if to underline ,he problem facing Unesco in achieving its aim, 1982 was also Information Technology Year in Britain. The juxtaposition of traditional and modern forms of communication is an apt symbol of the theme of this issue.

Since the time of Gutenberg the printed book has held a prominent place in the Western cultural and intellectual system. Today book production continues to increase around the world and developing countries are ever more anxious to combat …

First Case Of Sexual Cannibalism In Leiurus Abdullahbayrami Yağmur, Koç & Kunt, 2009 (Scorpiones: Buthidae) From Lebanon, Rami Khashab

Euscorpius

This study presents the first report of sexual cannibalism in the medically significant scorpion Leiurus abdullahbayrami Yağmur, Koç & Kunt, 2009, that was recorded during a herpetological field trip to the semi-desert area in northern Lebanon. It broadens the understanding of sexual cannibalism in scorpions and adds a new prey item to the dietary spectrum of the scorpion.

Improving Children's Television

Communication Research Trends

Few areas of television programming have provoked such strong public concern and protest as children's programmes. Parents and educators fear that television may be disrupting the balanced development of children's personalities or implanting harmful values. Most of the early research on children's television was an attempt to determine more accurately whether content was truly violent or manipulative and whether violence, advertising or other content was having destructive effects.

This public reaction also sparked moves in the late 1960s to carefully design programmes such as Sesame Street which would be entertaining, instructive and contribute to the intellectual-emotional growth of the child. …

Positively Impacting Traffic Safety Culture For Indigenous Youth: A Heritage-Focused Approach, Jacob Steven Pehrson, Ahmed Abdel-Rahim, Logan Prescott

Journal of Community Engagement and Higher Education

This paper presents the development of heritage-focused outreach materials with the objectives of positively impacting traffic safety culture for Indigenous youth to reduce the number and severity of traffic crashes impacting these communities. The approach presented in this paper includes involving local community leaders in traffic safety education and incorporating culturally based material in outreach education. This could empower Tribal communities to preserve their cultural identities while acquiring the expertise needed to promote traffic safety.

Service Learning As A Mode To Deliver Course Learning Outcomes In A Research-Based Exercise Science College Course, Jennifer Lape Kaiser, Madison Skaggs

Journal of Community Engagement and Higher Education

The following case study presents an approach to teaching research courses in undergraduate exercise science programs. Research courses are commonly required in the curriculum for this degree. Service learning (SL) is an effective way to promote student learning outcomes (SLOs) by providing hands-on experience for the students, and should be considered in exercise science research courses. Quantitative and qualitative survey results from students over two semesters of SL in an exercise science course are presented.

A Father-Friendliness Survey: How Do Community Organizations Report Engaging Fathers?, Kyle Miller, Jordan A. Arellanes

Journal of Community Engagement and Higher Education

This community-based project explored levels of father-friendliness across local organizations, agencies, and schools. A community coalition of individuals from diverse backgrounds and roles created a community survey to gather quantitative and qualitative information from individuals who worked with children or families. An analysis of survey responses (N=122) led to descriptive and thematic results of how the community served or marginalized fathers. Results were used to guide efforts in father engagement across various professional sectors.