Digital Commons Network^™

The Landscape Of Autosomal-Dominant Alzheimer's Disease: Global Distribution And Age Of Onset, Haiyan Liu, Thomas W Marsh, Xinyu Shi, Kevin M Bowling, Ellen Ziegemeier, Guoqiao Wang, Yuchen Cao, Alexa Dickson, Richard J Perrin, Michelle Doering, Alisha Daniels, Brian A Gordon, Tammie L S Benzinger, Jason Hassenstab, Laura Ibanez, Charlene Supnet-Bell, Chengjie Xiong, John C Morris, Randall J Bateman, Celeste M Karch, Carlos Cruchaga, Eric Mcdade, Jorge J Llibre-Guerra, Et Al.

2020-Current year OA Pubs

We present a comprehensive global analysis of genetic variants associated with autosomal-dominant Alzheimer's disease (ADAD). A total of 550 variants in the APP, PSEN1 and PSEN2 genes were identified, of which 279 were classified as pathogenic or likely pathogenic based on American College of Medical Genetics and Genomics and the Association for Molecular Pathology criteria, utilizing data from the Dominantly Inherited Alzheimer Network (DIAN), literature and public databases. Symptomatic age at onset (AAO) data were estimated for 227 of these variants, allowing detailed characterization of their frequency, pathogenicity and AAO. Importantly, 226 variants met eligibility criteria for inclusion in disease-modifying …

Washu Epigenome Browser Update 2025, Chanrung Seng, Shane Liu, Wenjin Zhang, Xiaoyu Zhuo, Daofeng Li, Ting Wang

2020-Current year OA Pubs

The WashU Epigenome Browser (https://epigenomegateway.wustl.edu/) is a web-based tool for exploring genomic data and providing visualization, investigation, and analysis of epigenomic datasets. Since its 2018 update, the redesigned user interface and newly developed features have enhanced how investigators interact with both the Browser and the extensive genomic data it hosts. The rapid evolution of the JavaScript ecosystem has presented new challenges and opportunities in maintaining and developing the WashU Epigenome Browser. In this update, we present a completely rewritten codebase. This new codebase minimizes the use of external libraries whenever possible, resulting in a significantly smaller code bundle size after …

Validation Of A 5-Item Tool To Measure Parent Assessment Of Clinician Compassion During Pediatric Visits., Eena S Lin, Alexandra Seabury, Mohammadsadegh Mikaeili, Joshua Bosire, Anthony Mazzarelli, Michael B. Roberts, Stephen Trzeciak, Brian W Roberts, Rafat Ahmed

PCOM Scholarly Works

Our objective was to validate a 5-item compassion measurement tool as a reliable measure of patient assessments of clinician compassion in the pediatric outpatient setting. We completed a cross-sectional study in a U.S. academic healthcare system consisting of six pediatric clinics between February and September 2023. We adapted the original 5-item tool to elicit responses regarding the pediatric patient. The measure was disseminated with the Clinician and Group Consumer Assessment of Healthcare Providers and System (CG-CAHPS) survey. We included patients aged < 18 years old who had an outpatient clinic visit and had a parent complete the CG-CAHPS survey. Validity testing of the 5-item tool was performed using confirmatory factor analysis. Internal reliability was tested using Cronbach's α, and convergent validity with overall provider rating questions from the CG-CAHPS survey was evaluated using Spearman correlation. We analyzed 640 responses. The median (interquartile range) patient age was 8 (3-13) years, and 47% of patients were female. Sixty-one percent of patients were White/Caucasian and 25% were Black/African American. Confirmatory factor analyses found a good fit. The compassion measure demonstrated good internal consistency (α = 0.97) and convergent validity with overall provider rating (r_s = 0.63 (95% confidence interval 0.56-0.70)) but reflected a patient experience domain distinctly different from what is currently …

Young Adult Literature Is Not As Young As It Used To Be, Clara Turnage

University of Mississippi News

OXFORD, Miss. – Despite its name, the young adult genre is increasingly dominated by stories about older teens and even adults. But as protagonists get older, younger readers are getting left behind, a University of Mississippi study indicates.

Low Premorbid Iq May Exacerbate The Cognitive Effects Of Apolipoprotein Ε4 (Apoe Ε4): A Multi-Ethnic Cross-Sectional Study From Habs-Hd, Lubnaa B. Abdullah, Zhengyang Zhou, Ney Alex Alliey, Robert Barber, James Hall, Sid O’Bryant

Psychological Science Faculty Publications

Introduction: Apolipoprotein allele 4 (APOE ε4) is associated with lower IQ scores during childhood and adolescence, but the influence of APOE ε4 and low IQ on late-life cognition is unknown. This study examines the association between APOE ε4 and cognitive outcomes based on premorbid intellectual ability (pIQ) and ethnic background.

Methods: Participants were drawn from the Health & Aging Brain Study–Health Disparities (HABS-HD), categorized by low (z ≤ −2.00) or average (z = 0.00 ± 1.00) pIQ based on word reading scores. Statistical analyses were conducted to evaluate whether APOE ε4 was associated with the cognitive domains of …

Consideration Of Patient Phenotypes In Geographic Atrophy Due To Age-Related Macular Degeneration, Rishi P Singh, Christina Y Weng, John W Kitchens, Jaclyn Quilantan, Roy Schwartz, Caroline R Baumal, Roger A Goldberg

Faculty, Staff and Students Publications

Geographic atrophy (GA) is a form of advanced age-related macular degeneration (AMD) affecting approximately 1 million people in the USA and 5 million globally. In this review, retinal imaging techniques used for diagnosis and monitoring progression of GA in AMD, and the risk factors associated with the development and progression of GA are summarised. To familiarise clinicians with common phenotypes of patients with GA, the clinical and imaging features that may lead to rapid progression of GA in various phenotypes are highlighted. With the recent US Food and Drug Administration approval of new GA treatments that reduce lesion growth, understanding …

Development And Validation Of A Novel Clinical Risk Score To Predict Hypoxaemia In Children With Pneumonia Using The Who Prepare Dataset, Rainer Tan, Arjun Chandna, Tim Colbourn, Shubhada Hooli, Carina King, Norman Lufesi, Eric D Mccollum, Charles Mwansambo, Joseph L Mathew, Clare L Cutland, Shabir A Madhi, Marta Nunes, Sudha Basnet, Tor A Strand, Kerry-Ann F O'Grady, Brad Gessner, Emmanuel Addo-Yobo, Noel Chisaka, Patricia Hibberd, Prakash M Jeena, Juan M Lozano, William B Maleod, Archana Patel, Donald M Thea, Ngoc Tuong Vy Nguyen, Marilla Lucero, Syed Mohammad Akram Uz Zaman, Shinjini Bhatnagar, Nitya Wadhwa, Rakesh Lodha, Satinder Aneja, Mathuram Santosham, Shally Awasthi, Ashish Bavdekar, Monidarin Chou, Pagbajabyn Nymadawa, Jean William Pape, Glaucia Paranhos-Baccala, Valentina S Picot, Mala Rakoto-Andrianarivelo, Vanessa Rouzier, Graciela Russomando, Mariam Sylla, Philippe Vanhems, Jianwei Wang, Romina Libster, Alexey W Clara, Fenella Beynon, Gillian Levine, Chris A Rees, Mark I Neuman, Shamim Qazi, Yasir Bin Nisar, World Health Organization Prepare Study Group

Faculty, Staff and Students Publications

Background: Hypoxaemia predicts mortality at all levels of care, and appropriate management can reduce preventable deaths. However, pulse oximetry and oxygen therapy remain inaccessible in many primary care health facilities. We aimed to develop and validate a simple risk score comprising commonly evaluated clinical features to predict hypoxaemia in 2-59-month-old children with pneumonia.

Methods: Data from seven studies conducted in five countries from the Pneumonia Research Partnership to Assess WHO Recommendations (PREPARE) dataset were included. Readily available clinical features and demographic variables were used to develop a multivariable logistic regression model to predict hypoxemia (oxygen saturation < 90%) at presentation to care. The adjusted log coefficients were transformed to derive the PREPARE hypoxemia risk score and its diagnostic value was assessed in a held-out, temporal validation dataset. The model and risk score were analysed by evaluating the area under the receiver operating characteristic curve (AUC), sensitivity and specificity.

Results: We included 14 …

Short-Run Fiscal Effects Of Expanding Michigan's Preschool Program To Be Universal, Timothy J. Bartik

Upjohn Institute Policy Papers

This policy paper provides some updated estimates of the short-run fiscal effects of expanding Michigan’s state-funded preschool program, the Great Start Readiness Program (GSRP), to encompass universal access for Michigan’s four-year-olds. This is an update to Policy Paper No. 2025-034, which analyzed the economic and fiscal effects of Michigan’s current GSRP program as compared to the state having no program. The update takes advantage of a high-quality recent study of the economic effects of universal preschool programs in nine states, authored by Jackson, Turner, and Bastian (2025). Using the estimated economic effects of universal preschool from this recent study, …

Impact Of A Mentorship Program On School Nurse Confidence, Shanna Groom

Doctor of Nursing Practice Projects

The prevalence of chronic health conditions in children has risen in recent years. As a result, school nurses are now expected to manage medically fragile students while also responding to acute and emergent health issues. This increasing complexity adds extra demands to school nurses, emphasizing the need for strong clinical decision-making skills and confidence. Mentorship programs have been proven to increase the confidence of nurses and are a core essential of the national standards and framework for school nurses. The problems addressed by this project were the lack of a mentorship program in a large school district for newly hired …

The Chemistry Workforce In The Mountain West, 2022, Sean Curry, Otoniel Ramos, Mohit Pande, Olivia K. Cheche, Caitlin J. Saladino, William E. Brown Jr.

Economic Development & Workforce

This fact sheet presents 2022 data on the industrial chemistry workforce in five Mountain West states: Arizona, Colorado, Nevada, New Mexico, and Utah. The American Chemistry Council’s (ACC’s) report, “2023 Guide to the Business of Chemistry,” offers insights into the chemistry industry’s role in the U.S. economy. This fact sheet focuses on 2022 state-level data related to the number of chemistry establishments, the number of individuals employed in the industry, and the average wages and salaries of industry workers in the Mountain West.

The Impact Of Agricultural Land Conversion On The Economy And Space Utilization In Jatimulyo And Way Huwi Villages, South Lampung Regency, Lampung Province, Yudha Rahman, Adnin Musadri Asbi, Annisa Maharani, Khalid Ahmad Ramadhan

Jurnal Geografi Lingkungan Tropik (Journal of Geography of Tropical Environments)

No abstract provided.

Law School News: Rwu Law Launches "Law 401" Podcast With Timely Dive Into Washington Bridge Debacle 07-07-2025, Kerri Tallman

Life of the Law School (1993- )

No abstract provided.

An Integrative Genomics Approach For The Discovery Of Potential Clinically Actionable Diagnostic And Prognostic Biomarkers In Colorectal Cancer, Mark Fertel, Duaa Mohammad Alawad, Chindo Hicks

School of Graduate Studies Faculty Publications

Background: Despite remarkable progress in clinical management of patients and intensified screening, colorectal cancer remains the second most common cause of cancer-related death in the United States. The recent surge of next generation sequencing has enabled genomic analysis of colorectal cancer genomes. However, to date, there is little information about leveraging gene expression data and integrating it with somatic mutation information to discover potential biomarkers and therapeutic targets. Here, we integrated gene expression data with somatic mutation information to discover potential diagnostic and prognostic biomarkers and molecular drivers of colorectal cancer. Methods: We used publicly available gene expression and somatic …

Domain-Adaptive Diagnosis Of Lewy Body Disease With Transferability Aware Transformer, Xiaowei Yu, Jing Zhang, Tong Chen, Yan Zhuang, Minheng Chen, Chao Cao, Yanjun Lyu, Lu Zhang, Li Su, Tianming Liu, Dajiang Zhu

Computer Science Faculty Research & Creative Works

Lewy Body Disease (LBD) is a common yet understudied form of dementia that imposes a significant burden on public health. It shares clinical similarities with Alzheimer’s disease (AD), as both progress through stages of normal cognition, mild cognitive impairment, and dementia. A major obstacle in LBD diagnosis is data scarcity, which limits the effectiveness of deep learning. In contrast, AD datasets are more abundant, offering potential for knowledge transfer. However, LBD and AD data are typically collected from different sites using different machines and protocols, resulting in a distinct domain shift. To effectively leverage AD data while mitigating domain shift, …

Introduction To Sociology: Race And Ethnicity, Dr. Marcia Morrison Ph.D.

Open Educational Resources

Abstract: This paper critically examines the phrase "one nation, indivisible" from the Pledge of Allegiance in light of the complex realities of race, ethnicity, and immigration in the United States. While the pledge asserts a unified national identity, this ideal is frequently undermined by systemic social, economic, and political divisions. Drawing from multicultural and sociopolitical frameworks, the paper explores how the lived experiences of marginalized groups—particularly racial and ethnic minorities and immigrant communities—reveal a fragmented national reality. The analysis engages with the implications of the 1965 Immigration Act, which, despite dismantling explicitly racist immigration quotas, restructured racial inequalities through new …

Energetic And Economic Aspects Of Rebound, Part I: Foundations Of A Rigorous Analytical Framework, Matthew Kuperus Heun, Gregor Semieniuk, Paul E. Brockway

University Faculty Publications and Creative Works

Widespread implementation of energy efficiency is a key greenhouse gas emissions mitigation measure, but rebound can “take back” energy savings. However, the absence of solid analytical foundations hinders empirical determination of the size of rebound. A new clarity is needed, one that involves both economics and energy analysis. In this paper (Part I), we advance foundations of a rigorous analytical framework for consumer-sided rebound that starts at the microeconomic level and is approachable for both energy analysts and economists. We develop foundations of a framework that (i) clarifies the energy, expenditure, and consumption aspects of rebound, (ii) combines embodied energy …

The Logic Of The Revenge Tax, Wei Cui

All Faculty Publications

Wei Cui is a professor in the Peter A. Allard School of Law at the University of British Columbia. In this article, Cui argues that the One Big Beautiful Bill Act’s formerly proposed section 899, targeting “unfair” foreign taxes, was more sensible than many observers initially perceived, and that, if seen as a restrained deployment of U.S. market power, it represented a defensible and ultimately acceptable approach for addressing the undertaxed profits rule and digital services taxes.

Anion Exchange Membrane Durability For Electrochemical Co2 Reduction In Membrane Electrode Assembly Cells, Soundarzo Tasnim

LSU Master's Theses

The electrochemical reduction of CO₂ using membrane electrode assembly (MEA) cells has emerged as a promising approach for carbon capture and conversion into valuable products. This study investigates the degradation mechanisms of anion exchange membranes (AEMs) in CO₂ reduction applications, focusing on Sustainion X37-50, PiperION, and FAA-3-50. The research analyzes the impact of chemical and mechanical degradation on membrane performance, highlighting key stability challenges in long-term operation. Fourier transform infrared spectroscopy (FTIR) and electrochemical impedance spectroscopy (EIS) were employed to monitor functional group stability and ionic conductivity loss over extended operation. The results indicate that hydroxide-induced degradation leads to nucleophilic …

Evolving Trends: A Bibliometric Analysis Of Academic Librarians’ Publications At Twelve Aau Member Universities, Pete E. Pascuzzi, Jason B. Reed, Greenley Goedde Creech

Libraries Faculty and Staff Scholarship and Research

The goal of this bibliometric study was to explore the broader publication patterns of academic librarians in both information and library science (ISLS) and interdisciplinary research for the years 2009 - 2023. Web of Science data were collected for twelve academic libraries. The results showed that while the number of ISLS publications has dropped, interdisciplinary publications have increased dramatically with a broad range of disciplines represented, and collaborations in the medical sciences were a major contributor to this increase. The study suggests that some academic libraries have shifted their priorities over the past fifteen years and that the assessment of …

Self-Determination In The Implementation Of Treaty Reserved Rights, Kekek Jason Stark

Tribal Law Journal

No abstract provided.

Fulfilling An Obligated Duty To The Diné By Incorporating And Defining A Core Principle, Tó’Eí’Iiná Até (Water Is Life) Into The Navajo Nation Tribal Water Code: Making A Connection To The Diné In The “Checkerboard” Area., M. Tyanne Benallie

Tribal Law Journal

No abstract provided.

Stop Killing The Klamath: Rights Of Nature Protections With Tribal Law, The National Historic Preservation Act, And Collaborative Management Strategies For A Tribe On The Front Lines Of Climate Change, Juliette A. Jackson

Tribal Law Journal

No abstract provided.

From The Silver Screen To The Phone Screen: The Coogan Act’S Struggle To Keep Pace With The Evolution Of Social Media, Anzario Bernard Serrant

Minnesota Journal of Law, Science & Technology

No abstract provided.

Why The Ai Act Fails To Understand Generative Ai, Claire Boine, David Rolnick

Minnesota Journal of Law, Science & Technology

No abstract provided.

Surpassing Bostock: Sec Filing Deficits Mask Prevalence Of Lgbtq+ Workplace Discrimination In Big Tech, Clovia Hamilton, Eric Sader, Benjamin Ale-Ebrahim

Minnesota Journal of Law, Science & Technology

No abstract provided.

Lower Your Expectation Damages: Bipa Reforms Amplify Need For Federal Standards In Biometric Data Privacy, Jessica Schmitz

Minnesota Journal of Law, Science & Technology

No abstract provided.

The Green Energy Landfill: Regulatory Approaches To The Disposal Of Decommissioned Wind Turbine Blades, Samuel Taylor

Minnesota Journal of Law, Science & Technology

No abstract provided.

Effects Of Fair Workweek Laws On Labor Market Outcomes, Joseph Pickens, Aaron Sojourner

Upjohn Institute Working Papers

This paper models fair workweek regulations that require employers to provide employees with (1) schedule predictability via advance notice of their work schedule and premium payments for short-notice changes, and (2) access to hours meaning they must offer open hours to existing employees before hiring new workers. We develop a theoretical model of employers’ responses to these provisions and their implications for employment. Guided by the model, we estimate the effects of recently-adopted fair workweek regulation in New York City’s fast-food sector using a synthetic difference-in-differences design. We find a null employment effect.

The Role Of Law In The Making—And Unmaking—Of Housing Policy, Addie Slanger

Montana Law Review

No abstract provided.

From Imaging To Computational Domains For Physics-Driven Molecular Biology Simulations: Hindered Diffusion In Platelet Masses, Catherine House, Ziyi Huang, Kaushik Shankar, Sandra Young, Meghan Roberts, Scott Diamond, Maurizio Tomaiuolo, Timothy Stalker, Lu Lu, Talid Sinno

Cardeza Foundation for Hematologic Research

When formed in vivo, murine hemostatic thrombi exhibit a heterogeneous architecture comprised of distinct regions of densely and sparsely packed platelets. In this study, we utilize high-resolution electron microscopy alongside machine learning and physics-based simulations to investigate how such clot microstructure impacts molecular diffusivity. We used Serial Block Face - Scanning Electron Microscopy (SBF-SEM) to image select volumes of hemostatic masses formed in a mouse jugular vein, producing high-resolution 2D images. Images were segmented using machine learning software (Cellpose), whose training was augmented by manually segmented images. The segmented images were then utilized as 2D computational domains for Lattice Kinetic …