Digital Commons Network^™

Gene And Alleles Of Tyk2 (Rs11085727) And Tyk2 (Rs34536443) Polymorphisms In Covid-19 Patients Using Arms-Pcr., Thuraya Habeeb, Adnan Aubaid

Al-Qadisiyah Medical Journal

The clinical presentation of COVID-19 varies greatly from case to another, with host characteristics playing a pivotal role. The immune system is a pivotal function in establishing the course of SARS-COV-2 infection. Severe instances of COVID-19 and the resulting death are caused less by the virus itself than by the destructive unrestrained immune response. Among the host determinants for poor disease prognosis is probably genetic vulnerability to dysregulated immune response. The objective of this work is to examine some of the host genetic variables that are being studied in relation to the severity of COVID-19. The complex relationship between autoimmunity …

Evaluating The Efficacy Of Venetoclax-Based Regimens In Relapsed/Refractory Acute Leukemia: A Real-World Study From Three Chinese Oncology Centers, Wei Zhang, Liyang Huang, Ming Zhao, Rui Chen, Huiwen Liu

Muthanna Medical Journal

Background: Relapsed or refractory (R/R) acute leukemia poses a significant therapeutic challenge, with limited options and poor prognosis. Venetoclax, a BCL-2 inhibitor, has shown promise in frontline acute myeloid leukemia (AML), but its real-world utility in R/R settings remains underexplored. Objective: To evaluate the efficacy and safety of venetoclax-based regimens in adult patients with R/R acute leukemia treated in routine clinical practice across three tertiary oncology centers in China. Methods: A retrospective multicenter study was conducted on 70 patients with R/R acute leukemia (AML or ALL) treated between January 2020 and December 2023. Patients received venetoclax combined …

Targeting The Pi3k/Akt/Mtor Pathway In Hormone-Receptor Positive Breast Cancer: A New Frontier In Precision Therapy, Rina Mehra, Arjun Nair, Sneha Iyer, Karthik Raman, Meera Joshi

Muthanna Medical Journal

Background: Hormone receptor-positive (HR+) breast cancer represents the most common subtype among Indian women and is typically managed with endocrine therapies. However, resistance to such therapies-often driven by activation of the PI3K/AKT/mTOR signaling pathway-poses a significant clinical challenge and necessitates the development of targeted treatment strategies. Objective: This review aims to evaluate the molecular basis, therapeutic efficacy, safety profiles, and real-world applicability of PI3K/AKT/mTOR inhibitors in the management of HR+ breast cancer, with a focus on their relevance within the Indian healthcare landscape. Methods: A comprehensive narrative review was conducted by searching PubMed, Scopus, Web of Science, and Google Scholar …

Integrating Molecular Insights Into Treatment Strategies: The Pi3k/Akt/Mtor Axis In Hr+ Breast Cancer Management In India, Ananya Deshmukh, Raghavendra B. Iyer, Priyanka Nair, Vivek Sharma

Muthanna Medical Journal

Background: The PI3K/AKT/mTOR pathway plays a pivotal role in endocrine resistance among hormone receptor-positive (HR+) breast cancer patients. Despite growing global access to pathway-targeted therapies, the clinical integration of molecular diagnostics in India remains limited. This study investigates the prevalence and prognostic implications of PI3K/AKT/mTOR pathway activation in HR+ breast cancer using patient-derived tumor tissue. Methods: This prospective observational study analyzed tumor samples from 60 HR+ breast cancer patients treated at a tertiary oncology center in India. PIK3CA mutation status was assessed via PCR-based genomic testing. Protein expression of p-AKT and mTOR was evaluated using immunohistochemistry. Survival data …

Obesity And Smoking Status: Relationships With Specific Pulmonary Functions In University Of Babylon College Of Pharmacy Students, Safa W. Aziz

Muthanna Medical Journal

Adult pulmonary function impairment is associated with both smoking and obesity, albeit the consequences vary from person to person. This study aims to evaluate the relationship between smoking and obesity and their relationship to specific pulmonary functions in a selected group of the population (University of Babylon College of Pharmacy students, Iraq). Materials and Methods: The observational study was carried out on 90 male students at the college pharmacy in the University of Babylon, Iraq. Students enrolled in this study were aged between 19-23 years. The control group (30 males) from general students in the college pharmacy without smoking, …

Cross-Section Study Of Iron Deficiency Anemia In A Group Of Adolescents: Frequency And Contributing Factors, Murtaza Hassan Hadi, Mostafa Abdalla Abdelkareem, Nasser Ghaly Yousif

Muthanna Medical Journal

Background: Iron deficiency anemia (IDA) remains a significant global health concern, particularly among adolescents. This study investigated the prevalence and contributing factors of IDA among adolescents at Al Hussain Teaching Hospital, addressing a critical knowledge gap in the Iraqi healthcare context. Methods: A cross-sectional study was conducted on 77 adolescent patients (ages 12-18 years) from October 01, 2024, to January 30, 2025. Data collection included hemoglobin levels, serum ferritin measurements, dietary iron intake assessment, and socioeconomic status evaluation. Statistical analysis employed descriptive statistics, chi-square tests for categorical variables, and multivariate analysis to identify contributing factors. Results: The …

Therapeutic Potential Of Bone Marrow-Derived Stem Cells In The Treatment Of Ewing Sarcoma: New Approach, Nasser Ghaly Yousif, Fadhil G. Alamran, Ahmed Altimimi

Muthanna Medical Journal

Background: Ewing Sarcoma is a challenging pediatric bone cancer with limited treatment options, particularly in advanced stages. Recent research has highlighted the potential of bone marrow-derived stem cells (BMSCs) as a novel therapeutic approach due to their tumor-targeting capabilities and ability to modulate the tumor microenvironment. Objective: This study aims to explore the therapeutic potential of BMSCs in the treatment of Ewing Sarcoma, focusing on innovative strategies that leverage their unique properties to enhance treatment efficacy and patient outcomes. Methods: This study involved a comprehensive review of the literature on BMSCs and their application in cancer therapy, …

The Effect Of Oral Health Education Program On Awareness And Improving Glycemic Control Of Patients With Type2 Diabetes In Erbil City, Sara Shaker, Ali Shakir Dauod

Al-Qadisiyah Medical Journal

the effect of oral health on diabetic control

Antibiotic Resistance For Diarrheagenic Escherichia Coli Isolated From Under 5 Years’ Age Patients In Al-Diwaniyah City, Azhar Ali, Manal M. Kadhim

Al-Qadisiyah Medical Journal

            Background: Escherichia coli, a common bacterium, is becoming increasingly resistant to antibiotics, making diarrhea treatment difficult. This is especially concerning for multidrug-resistant (MDR) and extended-spectrum beta-lactamase (ESBL)-producing strains. These "superbugs" can resist multiple antibiotics and spread easily among bacteria.Traditional treatments like ampicillin and tetracycline are becoming less effective. The Centers for Disease Control and Prevention (CDC) recommends fluoroquinolones, macrolides, and rifaximin for some cases, but these have limitations.             Aim of the study The present study aims to explore the antimicrobial resistance of diarrheagenic E. coli pathotypes to determinate the antibiotics resistance pattern.            Methodology Twelve isolates of diarrheagenic E. coli isolated …

The Association Between Type 2 Diabetes Mellitus, Hypertension & Severity Of Fibrosis In Patients With Nafld, Huda Jabbar Albdery, Zahraa Abdulaali Al-Mudhafar

Al-Qadisiyah Medical Journal

Background: Non-alcoholic fatty liver disease (NAFLD) considered the most common chronic hepatic disorders on a global scale. In the context of non-alcoholic steatohepatitis (NASH), hepatic steatosis is associated with lobular inflammation and cellular apoptosis, which may culminate in fibrosis and cirrhosis.  As being highly frequent condition in patients with type 2 diabetes (T2DM) and hypertension, NAFLD the identification of patients with higher risk of developing the more severe fibrosis remains obscured in clinical practice. Aim of the study: The aim of this study is to assess the severity of non-alcoholic fatty liver disease (NAFLD) in a sample of Iraqi patients …

Assessment Of Alpha Emission In The Saliva Of The Smokers Using Cr-39 (Ssntds), Mayyadah Hasan Rhaif Al-Sahlanee

Al-Qadisiyah Medical Journal

Background: The concentration of radionuclides in the saliva and blood samples are a good indicator of the human body’s radioactive contamination, the objective of current study was to design across sectional study to assess the alpha particals emitted from the smoker and nonsmoker saliva and blood samples. Materials and Method: The saliva and blood samples were collected from 88 healthy male and famel smoker and non-smoker aged 18- 82 years old. In saliva and blood samples from smokers and nonsmokers, the alpha track density was determined utilizing the efficient fission track analysis approach with CR-39 nuclear track detector. Results: High …

Therapeutic Consequences Of Micrornas In Non-Small Cell Lung Cancer: Relation Between Transfection And Cgis Methylation, Zahraa Mousa, Adnan H. Al-Hamadani

Al-Qadisiyah Medical Journal

non-small cell lung cancer (NSCLC) is now moving beyond conventional chemotherapy with the advent of molecular-targeted therapies, and a key therapeutic strategy is inhibition of specific cytokines essential for tumor vascularization currently, angiogenesis quantification to assess and predict the efficacy of antiangiogenic drugs is mainly based on the evaluation of microvascular density. However, this procedure is highly invasive, and its association with the clinical outcome is uncertain in many tumor types, including NSCLC .         

The Effect Of Knowledge, Attitude And Practice On Obesity And Its Related Complications In Medical Students, Rajaa Mohamed, Hassan Raji Jallab

Al-Qadisiyah Medical Journal

Background: Obesity, being a widespread epidemic, affects individuals of all age categories, spanning from children, teenagers, adults, to the elderly. The swift escalation of obesity cases is giving rise to an increasing array of ailments, thus evolving into a significant health dilemma. Vitamin D insufficiency stands out as a prevalent issue globally, ranking high among common conditions that can be prevented. Hence, it becomes crucial to delve into the depths of public consciousness and perceptions regarding this deficiency, pinpointing areas where daily routines could potentially hinder the maintenance of adequate vitamin D levels within their systems. Aim of the study: …

Gene Profiling And Clinicopathological Features For Prognostic Modeling Of Recurrence In Non-Metastatic Clear-Cell Renal Cell Carcinoma., Xuzhi Yan, Jian Chen, Dianzheng Zhang, Xiaodu Xie, Ziqian Wang, Chongliang Zheng, Junhao Jin, Jing Xu, Qian Yan, Qiuli Liu, Weihua Lan, Jun Jiang

PCOM Scholarly Works

BACKGROUND: Accurate risk stratification of renal cell carcinoma (RCC) is critical for selecting the most appropriate treatment options. Existing prognostic systems, which incorporate various clinical and pathological parameters, have limitations in terms of accuracy. However, it remains unclear whether integrating molecular data with clinicopathological features can enhance the identification of high-risk tumors. The objective of this study was to establish a model to predict RCC recurrence by integrating molecular data with clinicopathological features and to evaluate circulating tumor DNA (ctDNA) as a non-invasive prognostic marker.

METHODS: Next-generation sequencing (NGS) was performed on 73 RCC patients, including 54 with clear-cell RCC …

Data Protection’S Function In Society: A Search For The Limits Of A Non-Absolute Right, Katherine Nolan

Research Outputs: 2025-Present

No abstract provided.

Book Review: Designing Effective Language Learning Materials For Less Commonly Taught Languages. A Research-Based Guide, Susan Kresin

Russian Language Journal

Especially at a time when many Russian language instructors are actively expanding the scope of their instructional materials, this concise and well-articulated handbook fills an important gap. Focusing on the needs of instructors who teach less commonly taught languages, it offers a clear, step-by-step road map through the process of curricular and textbook design, with minimal theory and a broad framework of teaching methodology. This makes it applicable for a wide variety of practitioners in various circumstances: in pre-college, college and extracurricular settings, serving heritage, non-heritage and mixed groups of students, and at all levels.

Teaching Verbs Of Motion In A Task-Based Russian As A Foreign Language (Rfl) Course, Joan Castellví, Elena Markina

Russian Language Journal

The paper focuses on one of the most complex topics in Russian as a Foreign Language (RFL) instruction: verbs of motion (VoM). We introduce an innovative approach to teaching these verbs, grounded in Task-Based Language Teaching (TBLT), and contrast it with the traditional approach that follows the Presentation-Practice-Production (PPP) framework, which has dominated the field until now. By analyzing a sample of widely used textbooks specializing in VoM, we show that introducing the VoM system—specifically, the sequence in which the verbs are presented—follows the PPP design and is primarily grammar-oriented. This approach is based on the concept of “directionality,” which …

Do Your Abc: Teaching Tense And Aspect With Verbs Of Motion, Irina Six

Russian Language Journal

This paper examines the continued application of a content-based approach initially developed for teaching Russian verbs of motion (VoM) at the novice level (Six). It begins by introducing the ABC principle, a method that presents prefixed and unprefixed VoM together in their most typical contexts, rather than separately. The ABC principle ("A+B+C=D", as in поплыл + плыл + приплыл = плавал) helps visualize a three-leg journey and introduces students to two distinct sets of stems: Directional stems for A, B, and C verbs, and Non-directional stems for D verbs.

The paper then explores extending the ABC principle to intermediate-level …

Walang Atraksiyon: Pagdalumat Sa Karanasan Ng Mga Piling Pilipinong Aseksuwal Batay Sa Konsepto Ng Aseksuwalidad Nina Brunning At Mckeever, Christian Philip A. Mateo, Rowell Madula

Malay Journal

Tinalakay ng papel na ito ang karanasan ng mga aseksuwal na Pilipino gamit ang depinisyon ng aseksuwalidad nina Luke Brunning at Natasha McKeever bilang batayan. Isinagawa ang pakikipanayam sa apat na aseksuwal na Pilipino upang malaman ang kanilang proseso ng pagtuklas at pagtanggap sa kanilang aseksuwal na identidad, gayundin ang mga hamong kanilang hinarap sa isang lipunang hayperseksuwal. Naipakita sa papel na nagkakaiba ang bawat indibidwal sa pagtuklas at pagtanggap sa kanilang sarili, at walang iisang landas tungo sa pagkilala sa aseksuwal na identidad. Hinamon din ng mga ito ang mga karaniwang estereotipo tungkol sa aseksuwalidad, tulad ng maling paniniwalang …

Predicting The Influence Of Aggregate Size And Distribution On Cementitious Concrete Properties: A Review, Innocent J. Macha

Tanzania Journal of Engineering and Technology (TJET)

Cement concrete has been in use for centuries as one of the primary construction materials. Its demand in the construction industry is expected to continue for several centuries before the full development of alternative products. However, one of the main areas of research interest is understanding how its constituents can be tailored to make its properties predictable to reduce risks associated with structural failures, reconstruction and reduced durability. These hindrances associated with cementitious concrete result from several attributes, including constituent material characteristics, mixing ratios and workmanship. Understanding the predictability of cement concrete properties requires computer modelling tools to provide reliable …

Towards Future Sustainable Infrastructure: The Role Of Technical Audit In Tanzania’S Public Works, George C. Haule

Tanzania Journal of Engineering and Technology (TJET)

This study aimed to investigate the vital role and impact of technical audits in promoting sustainable infrastructure development in Tanzania. The role and effects of technical audits in long-term infrastructure development were studied using a mixed-methods approach with both quantitative and qualitative parts. Data were collected through analysis of technical audit documentation, a semi-structured questionnaire, and stakeholder interviews. The study revealed the various dimensions of infrastructure investment projects, including initiation and planning, design, procurement of contractors and consultants, contract management, environment, health, and safety. The technical audit findings reported weaknesses or non-performance issues in infrastructure planning at the national level …

Root Cause Analysis Of Performance Degradation For An Xyz Thermal Power Plant In Tanzania, Simon I. Marandu

Tanzania Journal of Engineering and Technology (TJET)

Thermal power plants in Tanzania have been experiencing performance degradation, typically arising from component and subsystem failures, which contribute to power system instability and unreliability. This paper presents a case study of the root causes of performance degradation of an XYZ thermal power plant. The study was conducted by reviewing plant documentations, including maintenance and operational data logbooks, and by standardising the approach through the adoption of ISO 14224:2016 for maintenance and reliability data exchange. Data evaluation was carried out using principal component analysis and scree plot analytical techniques to enhance the depth and accuracy of root cause identification. Additionally, …

Assessment Of Dry Mouth In A Palliative Population: A Comparison Between Patient-Reported Symptoms And Clinical Oral Dryness Scale Measurements, Emir Murphy Dourieu, Dominika Lisiecka, William Evans, Patricia Sheahan

Publications

The severity and impact of dry mouth in patients receiving palliative care is underreported, and assessment methods for this condition are lacking consensus. This study aimed to examine the severity of dry mouth in a palliative population as rated on a visual oral dryness scale and to compare these findings with the actual symptoms experienced by patients, as reported through both a symptom scale measure and a bother questionnaire. 40 participants took part in this cross-sectional study. The results indicated that xerostomia is a significant and debilitating symptom for many patients receiving palliative care. Daily activities such as speaking and …

Economic And Employment Outcomes Of Youth Vocational Education In Tanzania, William George

Tanzanian Economic Review

This study examines vocational education’s effectiveness in addressing youth unemployment and promoting economic self-reliance in Tanzania. Data from 394 vocational graduates were analyzed using descriptive statistics and regression models to assess the impact of vocational training on employment and economic outcomes. Results show that 83.6% of respondents believe vocational education provides essential employment skills, while 62.3% agree it enhances productivity. However, 39.3% highlight the need for reforms to better align training with labor market needs. The findings underscore vocational education's vital role in youth employment, advocating for curriculum updates and increased resources to improve system effectiveness.

Understanding The Complementarity And Substitutability Of Cooking Fuels In Developing Countries: Evidence From 2020/21 Tanzania National Panel Survey, Samwel Saimon Lwiza, Monica Sebastian Kauky

Tanzanian Economic Review

Increasing access to alternative energy sources in developing countries might be a potential for multiple energy consumption rather than switching from traditional to modern ones. This study aims to examine the complementarity and substitutability of cooking fuels and factors influencing households’ choices of such fuels in developing countries. Two categories of cooking energy were considered: traditional (dirty) fuels - firewood, charcoal and kerosene; and modern (cleaner) fuels - Liquefied Petroleum Gas (LPG) and electricity. Based on a nationally representative sample of 5,199 households from the Tanzania National Panel Survey (NPS) of 2020/21, results from a Multivariate Probit model indicate that …

New York Law School Selected As The Newest Partner Of The Daniel Anderl Scholarship Program, New York Law School

NYLS Community News

No abstract provided.

Who Bears The Burden? An Assessment Of Vulnerability And Resilience To Consecutive Disasters In The Portland Metro Region, Idowu Ajibade, Jason Sauer, Matthew Walter, James M. Done, Ming Ge, Elliot Gall, Aswatha Raghunathasami, Paul C. Loikith, Chris Lower, Heejun Chang, Arun Pallathadka, E Mae Sowards

Geography Faculty Publications and Presentations

Climate-related disasters threaten urban areas worldwide, yet gaps remain in understanding how multiple stressors interact to shape resilience. This study examines exposure, vulnerability, and resilience across three consecutive extreme events in the Portland metro area: the September 2020 wildfire-related air pollution, the February 2021 snowstorm, and the June 2021 heatwave. We used geographically weighted regression and Spearman rank correlation analysis to investigate relationships between hazard impacts, the social vulnerability index (SoVI), Baseline Resilience Indicators for Communities (BRIC), and proximity to community-based organizations (CBOs) in 416 census tracts. Our analysis reveals strong spatial correlations between wildfire-related air pollution, winter storm impacts, …

How Invasive Species Affect Ecosystems, Marion Murray, Meg Kast

All Current Publications

Invasive species can have profound impacts on ecosystems worldwide. In the absence of their natural enemies, invasive species thrive and reproduce quickly. They can have significant ecological and economic effects. This fact sheet outlines the impact of invasive species on biodiversity, nutrient cycles, water quality, and the resulting economic consequences. It also suggests practical tips for responding.

The Epilepsy Centers Of Excellence At The Veterans Health Administration, Zulfi Haneef, Caleb A Casanova, Vincent Zhang, Jennifer R Bonds King, Rizwana Rehman, Nina I Garga, Glenn D Graham, Alan R Towne

Faculty, Staff and Students Publications

Introduction: The Veterans Health Administration (VHA) Epilepsy Centers of Excellence (ECoE) was established in 2008 to provide specialized care for veterans with epilepsy. Although established more than a decade ago, there has been no systematic evaluation of the ECoE's performance in key mission areas. We evaluated their performance in several key mission areas-clinical care, research, education, and outreach-since inception to evaluate their success in meeting the initial mandate.

Materials and methods: We analyzed available data from relevant literature, ECoE annual reports, and the ECoE website between 2011 and 2023. Clinical care is the primary mission of the ECoE and was …

Frontmatter (Volume 45, Issue 6), Paul B. Mojzes

Occasional Papers on Religion in Eastern Europe

No abstract provided.