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Quality Improvement Project Improving Employee Satisfaction And Retention Through A Structured Training Process, Dawn Lundgren Jun 2025

Quality Improvement Project Improving Employee Satisfaction And Retention Through A Structured Training Process, Dawn Lundgren

Doctor of Nursing Practice Projects

The DNP project aimed to evaluate the impact of a structured new-hire training program on employee retention and job satisfaction within a hospice organization. Insufficient training for new employees can lead to a high staff turnover rate, stress, decreased job satisfaction, and poor quality of care. The quality improvement project utilized a pre-post intervention design over an eight-week period, comparing retention rates and job satisfaction scores before and after project implementation. Employee retention was measured as a binary outcome (retained or left), and job satisfaction was assessed through a seven-item survey rated on a five-point Likert scale. A total of …

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Quality Improvement Project Impacting Provider Efficiency And Burnout With Standardized Ordering Tools, Carly Meredith Jun 2025

Quality Improvement Project Impacting Provider Efficiency And Burnout With Standardized Ordering Tools, Carly Meredith

Doctor of Nursing Practice Projects

The adoption of electronic health record (EHR) systems promises better interoperability, transparency, patient safety, and care quality. However, concerns about increased provider stress and burnout are rising, suggesting a link between burnout and EHR use. This project aimed to evaluate whether improving EHR efficiency could reduce burnout rates. While literature highlights the need for enhanced training, effective methods remain unclear and challenge whether there is data supporting improvements or merely the perceived usefulness of these activities as identified through the Technology Acceptance Model. For this project, a preference list was created for commonly used orders with pre-selected defaults to streamline …

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Quality Improvement Project Improving The Management Of Diabetes In A Primary Care Setting Through Staff Education, Chibuzo Okereke Jun 2025

Quality Improvement Project Improving The Management Of Diabetes In A Primary Care Setting Through Staff Education, Chibuzo Okereke

Doctor of Nursing Practice Projects

Managing chronic disease, such as type 2 diabetes, requires effective patient education. This quality improvement project aimed to improve staff knowledge and confidence in delivering diabetes education using the evidence-based teach-back method. Eight staff members (physicians, nurse practitioners, nurses, medical assistants, and a clinic manager) of a suburban primary care clinic in Houston, Texas, were involved in the project by participating in structured educational sessions. The Always Use Teach-Back Conviction and Confidence Scale (CCS) and a Diabetes Knowledge Test 2 (DKT2) were validated instruments to measure data pre- and post-intervention. A quasi-experimental pre- and post-test design was used, and the …

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Enhancing Pre-Licensure Bsn Students' Clinical Knowledge And Confidence In Blood Transfusion Via Postpartum High-Fidelity Simulation, Tresia Rouse Jun 2025

Enhancing Pre-Licensure Bsn Students' Clinical Knowledge And Confidence In Blood Transfusion Via Postpartum High-Fidelity Simulation, Tresia Rouse

Doctor of Nursing Practice Projects

Blood transfusion administration is a complex nursing skill registered nurses require in bedside settings, regardless of experience level. Nursing students are expected to be practice-ready upon graduation. A significant concern in nursing academia is the insufficient exposure to administering blood products, which many pre-licensure nursing students lack in clinical and educational environments. This gap in nursing curricula can compromise students’ preparedness to perform this skill in real-world scenarios. The core purpose of this Doctor of Nursing Practice (DNP) quality improvement (QI) project was to enhance clinical knowledge and impact self-confidence regarding blood transfusion administration and management, specifically by implementing a …

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Quality Improvement Project Enhancing Self-Efficacy In Managing Patient No-Shows: A Staff-Focused Intervention, Aaron Wabang Jun 2025

Quality Improvement Project Enhancing Self-Efficacy In Managing Patient No-Shows: A Staff-Focused Intervention, Aaron Wabang

Doctor of Nursing Practice Projects

No-shows are widely reported in behavioral health venues. They hinder continuity of care, decrease clinic efficiency, and compromise patient care. The solution requires addressing patients’ behavior and internal facility processes. This quality improvement (QI) project aimed to reduce no-show rates by providing staff with tools and enhancing their self-efficacy in managing appointments. The project was conducted in a rural East Texas behavioral clinic. Clinic staff reported challenges with patient reminders, scheduling, and follow-up issues that cause increased no-shows. The QI project aimed to empower staff by providing evidence-based scheduling strategies and decision support resources to enhance their confidence and attendance …

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Elder Fraud In The Mountain West, 2023, Taylor Volk, Madison Dwyer, Caitlin J. Saladino, William E. Brown Jr. Jun 2025

Elder Fraud In The Mountain West, 2023, Taylor Volk, Madison Dwyer, Caitlin J. Saladino, William E. Brown Jr.

Criminal Justice

This fact sheet presents data on complaints of fraud affecting individuals over the age of 60 and associated financial losses reported by elderly individuals in the Mountain West. The 2023 Elder Fraud Report serves to illuminate trends in elder fraud reports throughout the 50 U.S. states, Washington, D.C., Puerto Rico, Guam, U.S. Minor Outlying Islands, American Samoa, U.S. Virgin Islands, and Northern Mariana Islands. This fact sheet focuses on elder fraud data for the Mountain West states of Arizona, Colorado, Nevada, New Mexico, and Utah.

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Fine-Scale Variability In Iceberg Velocity Fields And Implications For An Ice-Associated Pinniped, Lynn M. Kaluzienski, Jason M. Amumdson, Jamie N. Womble, Andrew K. Bliss, Linnea E. Pearson Jun 2025

Fine-Scale Variability In Iceberg Velocity Fields And Implications For An Ice-Associated Pinniped, Lynn M. Kaluzienski, Jason M. Amumdson, Jamie N. Womble, Andrew K. Bliss, Linnea E. Pearson

Faculty, Staff, and Students

Icebergs found in proglacial fjords serve as important habitats for pinnipeds in polar and subpolar regions. Environmental forcings can drive dramatic changes in the overall reduction in ice coverage across fjords in the circumpolar regions, with implications for pinnipeds that use ice for critical life-history functions, including pupping and molting. To better understand how pinnipeds respond to changes in iceberg habitat, we combine (i) iceberg velocity fields over hourly to monthly timescales, derived from high-rate time-lapse photogrammetry of Johns Hopkins Glacier and Inlet, Alaska, with (ii) aerial photographic surveys of harbor seals (Phoca vitulina richardii) conducted during the pupping (June) …

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Chancellor's Column: Community And Campus Are Partners In Success, Janet Schrunk Ericksen Jun 2025

Chancellor's Column: Community And Campus Are Partners In Success, Janet Schrunk Ericksen

Campus News Archive

No abstract provided.

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Celebrate Disability Pride This July, University Of Dayton Jun 2025

Celebrate Disability Pride This July, University Of Dayton

University Libraries Blog Archive

Explore library resources to commemorate the anniversary of a landmark civil rights law, signed 35 years ago.

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A Smart Blockchain-Based Privacy-Preserving Machine Learning Scheme In Iot Healthcare, J. Deepika, Sahana Shetty, A. Selvarani, Saroj Bala, Benita Gracia Thangam J, Pradeep G Jun 2025

A Smart Blockchain-Based Privacy-Preserving Machine Learning Scheme In Iot Healthcare, J. Deepika, Sahana Shetty, A. Selvarani, Saroj Bala, Benita Gracia Thangam J, Pradeep G

Baghdad Science Journal

The idea of Blockchain has infused various fields of study, and its widespread adoption is projected to grow exponentially in the near future. By executing concise pre-defined code snippets known as smart contracts on the Blockchain, the need for intermediaries can be eliminated, and the number of contract executions can be significantly increased. The application of blockchain technology and smart contracts, in conjunction with machine learning methods, to IoMT-based e-healthcare is critically examined in this article. The goal of this project is to investigate how automation and decentralisation might improve healthcare. Integrating these components offers the chance to handle medical …

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Successful Treatment Of Recalcitrant Eosinophilic Pustular Folliculitis With Dupilumab, Miguel Mansilla-Polo, Fernando Navarro-Blanco, Javier López-Davia, Rafael Botella-Estrada Jun 2025

Successful Treatment Of Recalcitrant Eosinophilic Pustular Folliculitis With Dupilumab, Miguel Mansilla-Polo, Fernando Navarro-Blanco, Javier López-Davia, Rafael Botella-Estrada

Sultan Qaboos University Medical Journal

Eosinophilic pustular folliculitis (EPF) is a chronic inflammatory condition characterised by the appearance of excoriated papules involving the face, neck, trunk, and root of limbs. It is a rare disease, and most treatments rely on reports of isolated cases or small case series. Numerous treatments have been employed throughout history, with variable effectiveness, including indomethacin, corticosteroids, calcineurin inhibitors, dapsone, cyclosporine, tetracyclines, isotretinoin or narrowband ultraviolet B therapy. We report the successful treatment of a 77-year-old female patient who presented to a tertiary care hospital in Valencia, Spain, in 2024 with refractory EPF, which significantly affected her quality of life due …

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Identifying And Exploring Successful Leadership Strategies To Improve Nurse Retention, Jennifer Triggs Rickerson Jun 2025

Identifying And Exploring Successful Leadership Strategies To Improve Nurse Retention, Jennifer Triggs Rickerson

Walden Dissertations and Doctoral Studies

Nurse turnover has become a critical concern in healthcare, as low retention rates lead to decreased patient care quality and increased operational costs. A critical issue for hospital stakeholders is that many nursing leaders lack strategies to improve nursing retention. Grounded in the leader-member exchange theory, the purpose of this qualitative pragmatic inquiry was to identify and explore successful leadership strategies used by nurse managers in the Pacific South region of the United States to improve nurse retention. The study included interviews with six nurse managers who successfully implemented retention strategies. Data were collected through semistructured interviews and publicly available …

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Artificial Intelligence And Autonomous Systems In Warfighting At Sea, Nicholas Kadlec Jun 2025

Artificial Intelligence And Autonomous Systems In Warfighting At Sea, Nicholas Kadlec

International Law Studies

Much of the debate surrounding the military use of artificial intelligence (AI) tends to focus on lethal autonomous weapons systems. Those are systems that, once activated, can select and engage targets without further human intervention; sometimes pejoratively called “killer robots.” Moreover, debates often focus on their use and risks in land warfare. This land-warfare focus tends to invoke questions about the systems’ ability to distinguish between combatants and civilians on urban battlefields and the potential for mistakes. Legal debates about the lawfulness of AI and lethal autonomous weapons systems in warfare similarly tend to focus on land warfare and thus …

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The Labor Supply Curve Is Upward Sloping: The Effects Of Immigrant-Induced Demand Shocks, Sigurd Galaasen, Andreas Kostøl, Joan Monras, Jonathan Vogel Jun 2025

The Labor Supply Curve Is Upward Sloping: The Effects Of Immigrant-Induced Demand Shocks, Sigurd Galaasen, Andreas Kostøl, Joan Monras, Jonathan Vogel

Upjohn Institute Working Papers

What is the effect of immigration on native labor-market outcomes? An extensive literature identifies the differential impact of immigration on natives employed in jobs that are more exposed to immigrant labor (supply exposure). But immigrants consume in addition to producing output. Despite this, no literature identifies the impact on natives employed in jobs that are more exposed to immigrant consumption (demand exposure). We study native labor market effects of supply and demand exposures to immigration. Theoretically, we formalize both measures of exposure and solve for their effects on native wages. Empirically, we combine employer-employee data with a newly collected data …

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Gender Differences In Regretted Consensual Sexual Experiences And Problematic Alcohol Use Among First-Year College Students, Shannon Shen, Soyoung Kwon, Sukho Lee Jun 2025

Gender Differences In Regretted Consensual Sexual Experiences And Problematic Alcohol Use Among First-Year College Students, Shannon Shen, Soyoung Kwon, Sukho Lee

Journal of Social, Behavioral, and Health Sciences

Regretted sexual behaviors and alcohol use often occur in tandem for college students; however, few studies have examined their interrelationships or the variance across gender. This study tested gender differences in how regretting a consensual sexual experience is related to college students’ alcohol use. One hundred and forty first-year students (63% women, 69% Hispanic) surveyed in 2018 and 2019 reported their sexual behavior and alcohol use (following the Rutgers Alcohol Problem Index [RAPI]). Twenty-one percent of men and 16% of women reported a regretted sexual encounter. Interaction effects from regression models revealed that men with sexual regret had a significantly …

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Association Of Anthropometric Indices With Rs9939609 Fto Gene Polymorphism Among Overweight/Obese Women With Breast Cancer: A Case-Control Study, Huma Naqeeb, Bismillah Sehar, Sami Siraj, Ali Madi Almajwal, Bibi Hajira, Moez Al Islam Faris, Sharifa Alblooshi, Ali Saad R. Alsubaie, Mahpara Safdar, Iftikhar Alam, Falak Zeb Jun 2025

Association Of Anthropometric Indices With Rs9939609 Fto Gene Polymorphism Among Overweight/Obese Women With Breast Cancer: A Case-Control Study, Huma Naqeeb, Bismillah Sehar, Sami Siraj, Ali Madi Almajwal, Bibi Hajira, Moez Al Islam Faris, Sharifa Alblooshi, Ali Saad R. Alsubaie, Mahpara Safdar, Iftikhar Alam, Falak Zeb

All Works

Background/objectives: Fat mass and obesity associated (FTO) gene and anthropometric measurements might be associated with breast cancer (BC) risk. This study aimed to assess the interactions between single nucleotide polymorphism (SNP) rs9939609 of the FTO gene, anthropometric indices, and BC risk among pre- and post-menopause women with overweight/obesity in Pakistan. Methods: This retrospective case–control study conducted on a convenience sample of 200 women divided into two groups: a case group comprised of 100 women diagnosed with BC, and control group comprised of 100 (age and menopausal status matched healthy women). Physical activity was assessed using validated questionnaire. Data on body …

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Who's At Home?: Individual-And Family-Level Sociodemographic Characteristics Associated With Stay-At-Home Motherhood, Deegan Minchey Jun 2025

Who's At Home?: Individual-And Family-Level Sociodemographic Characteristics Associated With Stay-At-Home Motherhood, Deegan Minchey

Theses and Dissertations

In this study, I assess the relationship between various types of demographic variables, including individual, partner, and family-level information, and the likelihood of mothers staying at home. Using nationally representative data from the 2019,2021, and 2023 waves of the Annual Social and Economic Supplement (ASEC) to the Current Population Survey to account for differences across the COVID-19 pandemic, this analysis examines the likelihood of becoming a stay-at-home mother (SAHM) across three separate regression models. From the variables analyzed, I find that various individual, family, and partner demographic characteristics are significantly associated with the likelihood of becoming a SAHM. These results …

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Autistic Traits In Fibromyalgia Are Associated With Hypersensitivity And Central Sensitisation, Helen Johnston, Alison Bacon Jun 2025

Autistic Traits In Fibromyalgia Are Associated With Hypersensitivity And Central Sensitisation, Helen Johnston, Alison Bacon

School of Psychology

Fibromyalgia presents with symptoms of central sensitisation (CS). Allodynia is the defining symptom, with evidence for general hypersensitisation extending beyond the pain symptoms that characterise fibromyalgia, to sensory and psychological domains. Generalised sensory processing sensitivity (SPS) may increase vulnerability to hypersensitisation; while a direct association exists between sensory sensitivity and autistic traits in autistic people, CS symptoms are also associated with autistic traits in a broader participant sample. This study complements previous lines of enquiry by examining the relationship between SPS, CS symptoms and autistic traits in samples with and without fibromyalgia. It proposes that SPS is indirectly associated with …

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Two Nyls Alumni Named To “Best Lgbtq+ Lawyers Under 40” List, Jennifer Bancamper Jun 2025

Two Nyls Alumni Named To “Best Lgbtq+ Lawyers Under 40” List, Jennifer Bancamper

NYLS Community News

No abstract provided.

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Common Fixed Points Results For Three Mappings Under Generalized Contraction Of Suzuki-Type In Ƀ-Metric Spaces With Application, Surjeet Singh Chauhan Gonder, Manju Devi, Manish Jain, Mohammad Sajid Jun 2025

Common Fixed Points Results For Three Mappings Under Generalized Contraction Of Suzuki-Type In Ƀ-Metric Spaces With Application, Surjeet Singh Chauhan Gonder, Manju Devi, Manish Jain, Mohammad Sajid

Baghdad Science Journal

Suzuki used a brilliant strategy in his seminal publications to expand the Banach contraction theorem (BCT). This has undergone numerous intriguing generalizations and extensions during the past few decades and led to a new trend of coincidence and fixed points for countless Suzuki-type contractive and non-expansive maps in the various spaces. In this article, in the setup of ƀ-metric spaces, the aim is to produce a common fixed point of three mappings subjected to a generalized contraction of the Suzuki type. The present work generalizes well- known results of Suzuki, Chandra et al., Roshan et al. and several other results …

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A Feedback Management System Based On Blockchain Technology For Educational Institutions, Diman M. Mohammed, Rana F. Ghani Jun 2025

A Feedback Management System Based On Blockchain Technology For Educational Institutions, Diman M. Mohammed, Rana F. Ghani

Baghdad Science Journal

The provision of feedback is an essential element in the process of enhancing the performance of an organization. With precise feedback, errors and possibilities for improvement can be determined. The purpose of every survey is to accurately capture individuals’ real feelings. Today, the majority of feedback data is stored in a database system, However, a lack of confidence in the database system results in inaccurate or partially compromised feedback. Blockchain is an innovative and promising technology that decreases security risks, eliminates fraud, and provides unprecedented levels of transparency to ensure feedback system efficiency. It is a decentralized ledger that has …

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Tweaking Ml-Kem (Kyber) And Ml-Dsa (Dilithium), Kumar Rahul Jun 2025

Tweaking Ml-Kem (Kyber) And Ml-Dsa (Dilithium), Kumar Rahul

Master’s Dissertations

Lattice-based cryptography is the use of conjectured hard problems on point lattices in Rn as the foundation for secure cryptographic systems. Attractive features of lattice cryptography include apparent resistance to quantum attacks (in contrast with most number-theoretic cryptography), high asymptotic efficiency and parallelism, security under worst-case intractability assumptions, and solutions to long-standing open problems in cryptography. This work surveys the structure, security, and optimization potential of two leading lattice-based cryptographic schemes: ML-KEM (Kyber) and ML-DSA (Dilithium). Special attention is given to their applicability in government-oriented post-quantum cryptographic systems, focusing on performance, implementation considerations, and resilience against known quantum threats. In …

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Brain Scanning: Assessing Emigration Of U.S. Scientific Talent To Surveille Strategic Implications For China’S Dual-Use Technological Capabilities, Diane Dieuliis, James Giordano Jun 2025

Brain Scanning: Assessing Emigration Of U.S. Scientific Talent To Surveille Strategic Implications For China’S Dual-Use Technological Capabilities, Diane Dieuliis, James Giordano

Strategic Insights

This commentary analyzes the emigration and remote collaboration of U.S.-trained scientists with China and assesses the strategic implications for Beijing’s dual-use research and development ecosystem. The authors argue that the transfer of scientific talent in fields such as artificial intelligence, quantum computing, synthetic biology, and neurotechnology strengthens China’s Military-Civil Fusion strategy and accelerates both non-kinetic and kinetic capabilities. At the same time, patterns of talent migration and collaboration can serve as indicators of China’s technological priorities, doctrinal shifts, and defense development timelines. The article proposes a balanced U.S. response that combines improved domestic talent retention, refined vetting of international partnerships, …

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Fantasy Novels, Romance, And Book Boyfriends: Romantic Views And Expectations Of Young Adult Women, Kennedy Dawn Morris Jun 2025

Fantasy Novels, Romance, And Book Boyfriends: Romantic Views And Expectations Of Young Adult Women, Kennedy Dawn Morris

Theses and Dissertations

Despite its drop in popularity, reading is a pastime that is enjoyed by many. As with other forms of media, there is the question of how consuming literature impacts individuals. This research study examines how reading fantasy novels impacts the romantic views and expectations of women in emerging adulthood. Social comparison theory and parasocial relationships were utilized in order to examine how young adult women compare their relationships and relationship ideals to those of fictional characters, as well as how young adult women decide which fictional relationships and/or characters are worth their admiration. The findings of this study suggest that …

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Lived Experiences Of Black African Non-Denominational Pastor’S Perceptions, Attitudes, And Beliefs Of Mental Health, And Their Referral Practice In The United States, Esther Paul Jun 2025

Lived Experiences Of Black African Non-Denominational Pastor’S Perceptions, Attitudes, And Beliefs Of Mental Health, And Their Referral Practice In The United States, Esther Paul

Walden Dissertations and Doctoral Studies

The high frequency of mental health issues within the Black African Christians communities and the insufficient use of mental health resources, was the driving forces for this study. This qualitative study aimed to explore the attitudes, beliefs, and lived experiences of non-denominational Black African pastors on mental health and identified potential barriers to mental health care and create culturally appropriate solutions by investigating their experiences. The theoretical basis of this study was centered on Goffman’s social stigma theory, which was created by Erwin Goffman, the social identity theory (SIT), and the role identity theory, the latter which served as the …

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Effective Strategies For Empowering Women In Aerospace: Shaping The Future Of Leadership, Mariel R. Forster Jun 2025

Effective Strategies For Empowering Women In Aerospace: Shaping The Future Of Leadership, Mariel R. Forster

Walden Dissertations and Doctoral Studies

Some aerospace leaders face challenges in implementing effective strategies to advance women in leadership roles in the industry. Executive leaders are concerned with the lack of strategies to retain women, which contributes to their underrepresentation in aerospace leadership. Grounded in transformational leadership theory, the purpose of this qualitative pragmatic inquiry was to explore the strategies aerospace leaders use to advance women in aerospace leadership. The participants were seven aerospace leaders from the Southeastern United States who had implemented successful retention strategies. Data were collected through semistructured interviews and a review of public documents. Through thematic analysis eight themes were identified: …

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Exploring Strategies In Manufacturing To Reduce Loss Of Workers And The Costs Associated With Turnover, Aaron Sterrett Jun 2025

Exploring Strategies In Manufacturing To Reduce Loss Of Workers And The Costs Associated With Turnover, Aaron Sterrett

Walden Dissertations and Doctoral Studies

High employee turnover rates in the U.S. manufacturing firms create significant operational and financial challenges. Leaders of U.S. manufacturing firms seek to address employee turnover, which threatens productivity, profitability, and long-term sustainability. Grounded in the competing values framework, this qualitative pragmatic inquiry project aimed to identify and explore manufacturers' efficient management strategies to reduce employee turnover. The participants were five individuals who work in different management roles within the manufacturing industry and have assisted in developing successful employee retention strategies. Data were collected using semistructured interviews and a review of organizational information. Four themes were identified during qualitative coding analysis: …

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Impact Of Military-Related Moves On Spousal Perinatal Depression Screening And Mental Health Services, Chambraia Jones Jun 2025

Impact Of Military-Related Moves On Spousal Perinatal Depression Screening And Mental Health Services, Chambraia Jones

Walden Dissertations and Doctoral Studies

Maternal depression, including perinatal depression (PND), poses significant public health risks to women, infants, and families. Although routine PND screening is recommended, limited research has examined screening and referrals among military spouses, an underserved population affected by frequent relocations and deployments. This study examined how permanent change of station (PCS) frequency affects PND screening and referrals to mental health services. Grounded in Bronfenbrenner’s socioecological model and the CDC’s social ecological model of health, eight research questions explored associations between PCS frequency, PND screening, referrals, and the moderating roles of military branch and deployment status. A quantitative cross-sectional design was used …

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Predictive Study Of The Relationship Between Self-Care And Professional Quality Of Life Among Licensed Counselors Impacted By Covid-19, Maria G. Billings Jun 2025

Predictive Study Of The Relationship Between Self-Care And Professional Quality Of Life Among Licensed Counselors Impacted By Covid-19, Maria G. Billings

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic has created unprecedented challenges for mental health professionals, significantly increasing burnout and secondary traumatic stress while reducing available resources and limiting opportunities for compassion satisfaction. The purpose of this cross-sectional, quantitative survey study was to determine whether self-care engagement predicts levels of burnout, secondary traumatic stress, and compassion satisfaction among counselors. Grounded in Stamm’s theoretical framework on compassion satisfaction and compassion fatigue, the Self-Care Assessment Worksheet (SCAW) was used to measure self-care engagement, and the Professional Quality of Life Scale (ProQOL-V) was used to assess burnout, secondary traumatic stress, and compassion satisfaction. The sample included 59 licensed …

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Intratumoral Neutrophil-To-Lymphocyte Ratio Is Mirrored By Circulating Neutrophil-To-Lymphocyte Ratio In Non-Small Cell Lung Cancer, Kyle G Mitchell, Younghee Lee, Nathaniel Deboever, Marcelo V Negrao, Hai T Tran, Edwin Parra, Lauren Byers, Alexandre Reuben, Lorenzo Federico, Chantale Bernatchez, Jing Wang, Mara B Antonoff, Ara A Vaporciyan, Stephen G Swisher, Tina Cascone, Ignacio I Wistuba, John V Heymach, Don L Gibbons, Jianjun Zhang, Daniel J Mcgrail, Boris Sepesi, Cara L Haymaker Jun 2025

Intratumoral Neutrophil-To-Lymphocyte Ratio Is Mirrored By Circulating Neutrophil-To-Lymphocyte Ratio In Non-Small Cell Lung Cancer, Kyle G Mitchell, Younghee Lee, Nathaniel Deboever, Marcelo V Negrao, Hai T Tran, Edwin Parra, Lauren Byers, Alexandre Reuben, Lorenzo Federico, Chantale Bernatchez, Jing Wang, Mara B Antonoff, Ara A Vaporciyan, Stephen G Swisher, Tina Cascone, Ignacio I Wistuba, John V Heymach, Don L Gibbons, Jianjun Zhang, Daniel J Mcgrail, Boris Sepesi, Cara L Haymaker

Faculty, Staff and Student Publications

Tumor-initiated emergency granulopoiesis results in expansion of the circulating neutrophil compartment and neutrophil recruitment into the tumor microenvironment (TME), which may in turn promote tumor progression. Although an elevated circulating neutrophil-to-lymphocyte ratio (cNLR) has repeatedly been demonstrated to be an adverse prognostic factor in patients with non-small cell lung cancer (NSCLC), whether this neutrophil expansion in circulation reflects a similar relative neutrophil abundance in the TME remains unclear. We sought to characterize the relationships between cNLR and the intratumoral neutrophil-to-lymphocyte ratio (tNLR), between tNLR and proteogenomic and immune features of NSCLC tumors, and between tNLR and prognosis.We analyzed tNLR (transcriptomic …

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