Digital Commons Network^™

Impacts Of Radiation On Metabolism And Vascular Cell Senescence, Junichi Abe, Khanh Chau, Anahita Mojiri, Guangyu Wang, Masayoshi Oikawa, Venkata S K Samanthapudi, Abigail M Osborn, Keila C Ostos-Mendoza, Karla N Mariscal-Reyes, Tammay Mathur, Abhishek Jain, Joerg Herrmann, Syed Wamique Yusuf, Sunil Krishnan, Anita Deswal, Steven H Lin, Sivareddy Kotla, John P Cooke, Nhat-Tu Le

Faculty, Staff and Student Publications

Significance: This review investigates how radiation therapy (RT) increases the risk of delayed cardiovascular disease (CVD) in cancer survivors. Understanding the mechanisms underlying radiation-induced CVD is essential for developing targeted therapies to mitigate these effects and improve long-term outcomes for patients with cancer.

Recent Advances: Recent studies have primarily focused on metabolic alterations induced by irradiation in various cancer cell types. However, there remains a significant knowledge gap regarding the role of chronic metabolic alterations in normal cells, particularly vascular cells, in the progression of CVD after RT.

Critical Issues: This review centers on RT-induced metabolic alterations in vascular cells …

Powerest: Statistical Power Estimation For Spatial Transcriptomics Experiments To Detect Differentially Expressed Genes Between Two Conditions, Lan Shui, Anirban Maitra, Ying Yuan, Ken Lau, Harsimran Kaur, Liang Li, Ziyi Li

Faculty, Staff and Student Publications

Recent advancements in spatial transcriptomics (ST) have significantly enhanced biological research in various domains. However, the high cost for current ST data generation techniques restricts the large-scale application of ST. Consequently, maximization of the use of available resources to achieve robust statistical power for ST data is a pressing need. One fundamental question in ST analysis is detection of differentially expressed genes (DEGs) under different conditions using ST data. Such DEG analyses are performed frequently, but their power calculations are rarely discussed in the literature. To address this gap, we developed PoweREST, a power estimation tool designed to support the …

Hyalinization-Based Pathologic Response And Immune Infiltration Following Neoadjuvant Radiotherapy With Or Without Immune-Checkpoint Blockade In Localized Undifferentiated Pleomorphic Sarcoma, R S Traweek, M Zoghbi, R Lazcano, B M Cope, A J Bishop, A Farooqi, D Mitra, A K Yoder, B A Guadagnolo, D R Ingram, K Wani, D Shamsutdinova, A J Lazar, W-L Wang, C P Scally, E Z Keung, K E Torres, K K Hunt, R Ratan, J A Livingston, M S Nakazawa, D M Araujo, S Patel, V Ravi, A P Conley, M A Zarzour, N Somaiah, C L Roland, E F Nassif Haddad

Faculty, Staff and Student Publications

BACKGROUND: Standard-of-care treatment of localized undifferentiated pleomorphic sarcoma (UPS) involves preoperative radiotherapy (RT) and surgery. Combination of RT with immune-checkpoint blockade (ICB) represents a promising new strategy.

METHODS: Our primary objective was to assess survival outcomes and pathologically documented response in patients receiving RT with or without ICB or chemotherapy.

RESULTS: In a retrospective cohort of 68 patients with primary or locally recurrent UPS who received neoadjuvant RT with or without ICB, the ICB group had greater tumor hyalinization than the non-ICB group (89% compared with 30%, P = 0.018). In the non-ICB group, 19/37 patients (51%) achieved hyalinization-based pathologic …

Dynamic Contrast-Enhanced Mri Processing Comparison For Distinguishing True Progression From Pseudoprogression In High-Grade Glioma, Ahmad Amer, Shehbaz Ansari, Apollo Krayyem, Suprateek Kundu, Swapnil Khose, Halyna Pokhylevych, Susana Calle, Chirag B Patel, Zixi Yang, Ho-Ling Anthony Liu, Jason M Johnson

Faculty, Staff and Student Publications

Background: Treatment-related changes may occur due to radiation and temozolomide in glioblastoma and can mimic tumor progression on conventional MRI. DCE-MRI enables quantification of the extent of blood-brain barrier (BBB) disruption, providing information about areas of suspicious postcontrast T1 enhancement. We compared DCE-MRI processing methods for distinguishing true disease progression from pseudoprogression in high-grade gliomas (HGGs).

Methods: We identified 110 patients with HGG treated with surgery and chemoradiation who underwent DCE-MRI to further interrogate areas of new/increasing enhancement. All patients had confirmatory surgery/biopsy with pathology-confirmed progression or pseudoprogression. Scans were performed at 3T and analyzed using nordicICE. The MCA, SSS, …

Kap1 Promotes Gastric Adenocarcinoma Progression By Activating Hippo/Yap1 Signaling Via Binding To Hnrnpab, Shumei Song, Yibo Fan, Gengyi Zou, Longfei Huo, Janani Kumar, Yuan Li, Ruiping Wang, Enyu Dai, Jiankang Jin, Ailing W Scott, Shan Shao, Melissa Pool Pizzi, Jody V Vykoukal, Hiroyuki Katayama, Samir Hanash, George A Calin, Xing Zhang, Min Gyu Lee, Zhenning Wang, Yuan-Hung Lo, Qiong Gan, Rebecca E Waters, Feng Yin, Linghua Wang, Xiaodong Cheng, Jaffer A Ajani, Shilpa S Dhar

Faculty, Staff and Student Publications

Gastric adenocarcinoma (GAC) remains a significant global health challenge, with over a million new cases annually. Peritoneal carcinomatosis (PC), detected in ∼20 % of cases at diagnosis and ∼45 % later, is uniformly fatal, with limited treatment options. This study investigated the role of KAP1 in GAC progression, focusing on its interaction with YAP1 and cancer stemness traits. Analysis of over 596 primary GACs and 72 PC samples revealed that high nuclear KAP1 expression correlates with poor prognosis. KAP1 knockdown reduced oncogenic activity and stemness traits in GAC cells. Mechanistically, KAP1 positively regulates YAP1 transcription by binding to its promoter …

Tumour And Microenvironment Crosstalk In Nsclc Progression And Response To Therapy, Zahraa Rahal, Roy El Darzi, Seyed Javad Moghaddam, Tina Cascone, Humam Kadara

Faculty, Staff and Student Publications

The treatment landscape of non-small-cell lung cancer (NSCLC) is evolving rapidly, driven by advances in the development of targeted agents and immunotherapies. Despite this progress, some patients have suboptimal responses to treatment, highlighting the need for new therapeutic strategies. In the past decade, the important role of the tumour microenvironment (TME) in NSCLC progression, metastatic dissemination and response to treatment has become increasingly evident. Understanding the complexity of the TME and its interactions with NSCLC can propel efforts to improve current treatment modalities, overcome resistance and develop new treatments, which will ultimately improve the outcomes of patients. In this Review, …

Semi-Automated Hippocampal Avoidance Whole-Brain Radiotherapy Planning, Dong Joo Rhee, Subha Perni, Kelly J Perrin, Kevin E Casey, Alexandra O Leone, Callistus M Nguyen, Laurence E Court, He Wang, Xin Wang, Eun Young Han

Faculty, Staff and Student Publications

Background: Hippocampal avoidance whole-brain radiotherapy (HA-WBRT) is designed to spare cognitive function by reducing radiation dose to the hippocampus during the treatment of brain metastases. Current manual planning methods can be time-consuming and may vary in quality, necessitating the development of automated approaches to streamline the process and ensure consistency.

Purpose: To automate hippocampal avoidance whole-brain radiotherapy (HA-WBRT) planning.

Methods: Our algorithm automatically contours organs-at-risk (OARs) and the hippocampal-avoidance brain target. The algorithm generates planning structures from given contours, utilizing preset beam parameters and dose constraints for optimization. If the dose constraints are unmet, "hotspot" contours will be created to …

1d Thermoembolization Model Using Ct Imaging Data For Porcine Liver, Rohan Amare, Danielle Stolley, Steve Parrish, Megan Jacobsen, Rick R Layman, Chimamanda Santos, Beatrice Riviere, Natalie Fowlkes, David Fuentes, Erik Cressman

Faculty, Staff and Student Publications

Innovative therapies such as thermoembolization are expected to play an important role in improving care for patients with diseases such as hepatocellular carcinoma. Thermoembolization is a minimally invasive strategy that combines thermal ablation and embolization in a single procedure. This approach exploits an exothermic chemical reaction that occurs when an acid chloride is delivered via an endovascular route. However, comprehension of the complexities of the biophysics of thermoembolization is challenging. Mathematical models can aid in understanding such complex processes and assisting clinicians in making informed decisions. In this study, we used a Hagen-Poiseuille 1D blood flow model to predict the …

Risk Of Early Death After Acute Leukemia Diagnosis Among Adolescents And Young Adults, Amy M Berkman, Clark R Andersen, Vidya Puthenpura, Nicholas J Short, Kelly Merriman, Mahesh Swaminathan, Branko Cuglievan, David Mccall, Courtney Dinardo, Cesar Nunez, Nitin Jain, Tapan Kadia, Ghayas Issa, Amber Gibson, Miriam B Garcia, J Andrew Livingston, Susan Parsons, Michelle A T Hildebrandt, Michael E Roth

Faculty, Staff and Student Publications

Background: Advances in care have led to improvements in survival for adolescents and young adults (AYAs) diagnosed with cancer; however, the risk of early death remains high for certain cancers, particularly acute leukemias. Risk factors for early death in AYAs diagnosed with acute leukemia have not been well studied.

Methods: The Surveillance, Epidemiology, and End Results registry was used to assess risk of early death (within 2 months of diagnosis) in AYAs diagnosed with acute leukemia (n = 16 153). Early death proportion, by year, for AYAs diagnosed between 2006 and 2020 was described. Associations between incidence of early death …

A Follow-Up Study On The Novel Use Of Contrast-Enhanced Susceptibility-Weighted Imaging For Extremity Desmoid Fibromatosis Response Assessment, Raul F Valenzuela, Elvis Duran-Sierra, Mathew Antony, Behrang Amini, Sam Lo, Keila E Torres, Ken-Pin Hwang, Jingfei Ma, R Jasson Stafford, Ravin Ratan, John E Madewell, Dejka Araujo, William A Murphy, Colleen M Costelloe

Faculty, Staff and Student Publications

Desmoid tumors are rare mesenchymal neoplasms characterized by a clonal proliferation of fibroblasts and myofibroblasts. Using the novel contrast-enhanced susceptibility-weighted imaging (CE-SWI) for characterizing desmoid tumors can enhance the separation between fibrous T2-hypointense and cellular T1-enhancing components. We aim to evaluate the effectiveness of the CE-SWI signal, volumetric, and radiomics-derived features in assessing desmoid treatment response. This IRB-approved study included 17 single-lesion extremity desmoid fibromatosis patients who underwent standard-of-care MRI, including CE-SWI, from March 2021 to February 2024. Measurements of maximum diameter, volume, and the modified Choi (m-Choi: tumor/muscle T2 ratio) were computed based on CE-SWI and T2-STIR volumetric tumor …

The Sports-Betting Market: A Road To Sports Betting As Viable Investing, Tyler Gottlieb

Vanderbilt Journal of Entertainment & Technology Law

Since its legalization, sports betting has experienced rapid growth, both in terms of economic output and expansion into more states. The current system of sports betting in the United States requires individuals to place bets using a sportsbook. The sportsbook sets the lines on every bet. If an individual wins their bet, the sportsbook pays them money according to the listed odds. If an individual loses their bet, the sportsbook keeps the amount staked. Sportsbooks set lines in a way to ensure that on average, they make money on every bet. This system has been widely accepted, often based on …

Cdemapper: Enhancing National Institutes Of Health Common Data Element Use With Large Language Models, Yan Wang, Jimin Huang, Huan He, Vincent Zhang, Yujia Zhou, Xubing Hao, Pritham Ram, Lingfei Qian, Qianqian Xie, Ruey-Ling Weng, Fongci Lin, Yan Hu, Licong Cui, Xiaoqian Jiang, Hua Xu, Na Hong

Faculty, Staff and Student Publications

Objective: Common Data Elements (CDEs) standardize data collection and sharing across studies, enhancing data interoperability and improving research reproducibility. However, implementing CDEs presents challenges due to the broad range and variety of data elements. This study aims to develop a CDE mapping tool to bridge the gap between local data elements and National Institutes of Health (NIH) CDEs.

Methods: We propose CDEMapper, a large language model (LLM)-powered mapping tool designed to assist in mapping local data elements to NIH CDEs. CDEMapper has 3 core modules: (1) CDE indexing and embeddings. NIH CDEs were indexed and embedded to support semantic search; …

Assessing Health And Academic Disparities In The Deep South: The Enduring Impact Of Segregation And Redlining In Georgia, Bridget Hamilton

Theses and Dissertations

Background: Within the American South, marginalized Black populations continue to suffer from health disparities. A key resource that could aid in the prevention of health disparities such as teen pregnancy is the school nurse. School nurses are well positioned to assist in the development of independent health maintenance among student populations. However, school nurses remain understaffed and underfunded throughout most of the United States, which limits their effectiveness. It is possible that within southern states there are inequities in how school resources are allocated that have ties to segregation and redlining practices that systemically marginalized Black populations throughout the 1900s. …

Different Beliefs About Collective Victimisation Predict Support For Distinct Resistance Strategies: Survey Findings Among The Kurdish Diaspora, Helin Ünal, Johanna Vollhardt

Psychology

People make sense of their group's collective victimisation in different ways. These different collective victimisation beliefs may be linked to distinct resistance strategies against the ingroup's victimisation. However, most studies have only examined a few collective victimisation beliefs and resistance strategies, limited to prototypical collective action and failed to consider which constructs are most relevant for the given context. Addressing these gaps, the present study uses a multimethod approach with findings from a Q methodology study informing a survey study to examine the relationship between context-relevant, understudied collective victimisation beliefs and resistance strategies among Kurds from Turkey and Northern Kurdistan …

Self-Regulated Thermal Management With Shape-Memory Alloy Torsional Tubes, Paula Sanjuan Espejo

Doctoral Dissertations and Master's Theses

The need for dynamic thermal management that adapts to varying system needs and requirements is a growing topic of interest in different engineering disciplines, most prominently aerospace and electronics. This demand for improved thermal management systems comes from the general increase of system efficiencies leading to an increase in component energy density. Shape-memory alloy actuators, which respond with a mechanical shape recovery to variations in temperature, can be used as self-regulated thermal management actuators that are able to respond to environmental thermal changes autonomously. In this dissertation, modeling and experimental analysis of a two-way shape-memory effect trained SMA torsional tube …

Embeddable Multi-Material Wireless Micro-Sensors Utilizing Additive Manufacturing And Enhanced Microstructure, Nicholas Reed

Doctoral Dissertations and Master's Theses

The development of embeddable, multi-material wireless microsensors offers transformative potential for structural health monitoring (SHM) in aerospace applications. This work integrates additive manufacturing (AM) techniques with advanced microstructural design to produce flexible, high-resolution sensors that can be directly embedded into polymer substrates. By utilizing the vat photopolymerization process, customized embedded sensors are seamlessly integrated into polymer AM structures. These sensors are then continuously refined, targeting increases in performance, both internal and external. Microstructural enhancements are explored to modify the rheological properties of the fabricated embedded sensing channels and enhance the adhesive bonding between the embedded sensor and the AM structure. …

Evaluation Of Waste Plastic Addition Via Dry Method On Asphalt Mixture Performance, Isabella Madeira Bueno

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Incorporating waste plastic (WP) into hot mix asphalt (HMA) offers a promising approach to enhance recycling rates and improve asphalt concrete (AC) performance, particularly in moisture damage resistance. However, results vary widely due to differences in WP types, sizes, and mixing methods. The lack of standardized procedures, especially for the dry process, has led to inconsistent integration and unclear roles of WP in AC mixtures. Studies suggest that introducing WP to pre-heated aggregates at temperatures exceeding its melting point can enhance mixture resistance to rutting, cracking, and moisture damage. In this context, this study was conducted in two phases to …

Chronic Illness Education 2025: Patient Education Resources For Women With Chronic Kidney Disease, Aiden Tang, Carolyn Nagengast, Faith Scott, Isaiah Delaney, Jonathan Hakim, Kandis Fox, Katie Webster, Mahmoud Saad

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Resources To Treat Seasonal Affective Disorder, Amanda Teschner, Ayonitemi Odukoya, Brooke Waldon, Joshua Spence, Katelynn Paluch, Marilyn Li, Mercylia Untono, Nina Agemy

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Holistic Approach To Hiv Treatment And Management, Aniela Crayton, Harvey Sharma, Jacob Saenz, Justin Iqal, Marie Clancy, Olivia Carlisle, Raphaela Varella, Tarun Bomma

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Promoting Lifestyle Changes To Manage Hypertension In Underserved Adult Populations, Gabriel Doree, Jenna Uhles, Kathryn Benninghoff, Magd Boutany, Omar Abdalla, Rhea Sehgal, Udodirim Nwosu, Yiannos Demetriou

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Building Healthy Habits: Preventative Strategies For Childhood Obesity, Alissa Ward, Cameron Craig, Chloe Sutlick, Gabrielle Henry, Isabelle Adams, Jerimiah Gumma, Omer Abdullah, Sami Zaidi

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Resources For Addressing Copd In The Veteran Population, Daniel Molnar, Tochi Mbagwu, Kiana Sechler, Lillian Centlivre, Noah Kos, Tomilola Oyasiji, Safia Haniya Yusuf

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Improving Access To Educational Resources And Health Outcomes For Diabetes, Ami Suresh, Conner Slotnick, Danielle Santoyo, Eric Mylfurry, Karen Abdelmalek, Martin Murad, Preston Parana, Urva Mehveen

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Persistent Obesity In A College Student: A Case For Investigating Endocrine Disruptors In Diet, Jake Mcgue, Jolyna Chiangong, Katarina Woldt, Mary-Ann Essak, Muiz Muqri, Nikhil Patel, Redi Gishto

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Exercise Initiatives To Improve Child Obesity, Alice Werynski, Ashley Simbafo, Diana Kernen, Koa Williams, Linda Beqaj, Noah Krepostman, Trevor Buck

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Improving Outcomes Of Hiv In Marginalized Populations, Aidan Bailey, Alexis Bowles, Ammar Chauhdri, Biola Makinde-Odusola, Dea Kanani, Keshav Sharma, Vasanth Palanisamy, Waffa Bakheet

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Resources To Improve Incidence Of Atherosclerotic Cardiovascular Disease, Anthony Kavanagh, Arianna Mcclellan, Asa Smith-Villegas, Djelika Kabore, Lina Shalaby, Tara Rahmani, Vyom Grover, Zackariah Farah

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Managing Hiv In Youth: A Case-Based Application Of The Expanded Chronic Care Model, Adam Kabbani, Ali Nasser, Emi Ueda-Martinez, Kristina Rizo, Mason Gardiner, Matthew Manson, Rachel Chee, Sydni Rosenfeld

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Addressing Adolescent Depression Through Community And Systems-Based Care, Anirudh Gopalam, Connor Genschaw, Don'aa Williams, Gerardo Rubio Monroy, Jennifer Nnadozie, Murray Meri, Tina Tripathi, Abdullah Mahmood

Patient Education Projects

No abstract provided.