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Ihpp 2024 Annual Report, Institute For Health Policy And Practice

All Materials

No abstract provided.

Two Essays In Finance: Can Machines Better Predict Insider Trading? And Csr And Firm Value Following Dividend Cuts: International Evidence, Solmaz Batebi

Theses and Dissertations

This dissertation consists of two essays. In the first paper, I find that machine learning (ML) models predict the likelihood and magnitude of insider trading significantly better than linear models such as OLS and logistic regression. I use ML models, including LASSO, Random Forest, and eXtreme Gradient Boosting, optimizing model parameters through Bayesian hyperparameter tuning to identify the best configuration. Additionally, I apply SHAP values to better understand the determinants of insider trading. I also use Gaussian Thompson Sampling (GTS) to explore the sources of insiders’ market-timing capabilities. I find that ML models can boost the R² for models predicting …

Electrocatalytic Degradation Of Methylene Blue Using Graphene Oxide, Antimony Oxide, And Graphene Oxide-Supported Antimony Oxide Ink-Based Electrodes, Maria Irene Myers Armas

Theses and Dissertations

This study investigates the electrocatalytic degradation of methylene blue (MB) using copper mesh electrodes coated with graphene oxide (GO), antimony oxide (Sb₂O₃), and their composite (GO/Sb₂O₃). These materials were evaluated across a pH range of 2 to 8 using sodium sulfate as the supporting electrolyte. UV-Vis spectroscopy at 665 nm confirmed dye degradation, with removal efficiencies reaching up to 95% at pH 2. However, degradation decreased at higher pH, with 40 – 60% removal at pH 8, depending on the electrode. Kinetic analyses revealed optimum performance under acidic conditions. GO/Sb₂O₃ electrodes demonstrated the most consistent and effective performance across all …

Foxo Factors’ Ability In Binding To And Inducing Tcf7 In Glioblastoma Cells, Stephanie Oyervides

Theses and Dissertations

Glioblastoma Multiforme (GBM) is an aggressive astrocytoma tumor type with a poor prognosis and limited immunotherapeutic options for those inflicted. Stem gene expression of this cancer indicates a direct relationship with the transcription factors, Forkhead box subfamily O (FOXO-1, -3 and - 4). These transcription factors are evolutionarily conserved, partially redundant. They are involved in diverse and fundamental biological processes such as cell survival, stem cell homeostasis, cell fate determination, cell cycle maintenance, metabolism, and apoptosis. Increasing evidence suggests interconnectivity between the WNT Pathway and FOXO transcription factors; however, the mechanism and full extent to which these interactions play a …

Sequential Data Modeling Of Influenza A Via Traditional, Dwt-Gpr Hybrid, And Deep Learning Architectures, Edmund Fosu Agyemang

Theses and Dissertations

Influenza A is responsible for 290,000 to 650,000 respiratory deaths a year, though this estimate is an improvement from years past due to improved sanitation, healthcare practices, and vaccination programs. In this study, we perform a comparative analysis of traditional, deep-learning and discrete wavelet (DWT)-Gaussian Process (GP) hybrid models to predict Influenza A outbreaks. Using historical data from January 2009 to December 2023, we compared the performance of traditional ARIMA and ETS models, four variants of DWT-GPR models and six distinct deep learning architectures: Simple RNN, LSTM, GRU, BiLSTM, BiGRU and Transformer. The results reveal a clear superiority of all …

Contributions Of Citizen Science Data To Butterflies Of The Lower Rio Grande Valley, Akane Jazmyn Benitez

Theses and Dissertations

Citizen science-provided insect data inherently exhibits variability in accuracy. In the Lower Rio Grande Valley (LRGV), butterfly occurrence reporting is predominantly reliant on citizen science contributions. My research compared fieldwork conducted monthly over a year to occurrence records submitted by visitors at the National Butterfly Center and in Mission, Hidalgo County, Texas. I hypothesized that butterfly occurrences at the Center would be maximized during the fall and minimized during winter and summer months. My research findings revealed that butterfly taxa richness is contingent upon the following factors: 1) the impact of citizen science submitting reports, and 2) monthly butterfly activity …

Oxytocin As A Possible Vegf Inhibitor For Treatment Of Diabetic Retinopathy, Daira Yepez

Theses and Dissertations

Diabetic retinopathy (DR) is a major complication of diabetes and a leading cause of vision loss largely driven by the overexpression of vascular endothelial growth factor (VEGF), which promotes neovascularization and vascular permeability in the retina. Current treatments, primarily anti-VEGF injections, inhibit the effects of VEGF once it has been secreted but can be ineffective in a certain subset of patients. Recent studies suggest that oxytocin (OXT), a neuropeptide mainly known for its roles in reproduction and social bonding, may downregulate VEGF expression. This study aimed to investigate whether OXT influences VEGF secretion in the human retinal pigment epithelial (RPE) …

Returning To Nature: A Virtue-Based Approach To Urban Sustainability, Liam A. L. Cormack

Cities and the Environment (CATE)

This paper advocates for a pragmatic and virtue-ethics-based approach to urban sustainability initiatives that prioritizes the consideration of moral responsibility. Looking at literature on rewilding, this paper argues that the principle of ecophronesis, and the larger discipline of ecopracticology, offers a compelling framework for integrating diverse opinions on the future of conservation from different disciplines and ecological stakeholders. Ultimately, an ecophronetic approach to urban sustainability initiatives facilitates a sense of conceptual rewilding that disregards the nature-culture dualism paradigm limiting Western environmental thought and may help address the perceived alienation from nature characterized by nature-deficit disorder.

Profile Of Trna-Derived Short Non-Coding Rnas During Monocyte Differentiation And Their Role In Macrophage Survival, Anahita Jayaram, Sanjeev Galande, Soroush Sharbati, Deepak A. Deshpande, Phd, Kamlesh Pawar

Center for Translational Medicine Faculty Papers

Monocytes, a type of leukocytes, are key players in immune responses, transitioning to macrophages at infection sites. Differentiation, which is crucial for macrophage survival and resistance to apoptosis, is a tightly regulated process. Based on our earlier findings implicating the 5'-fragment of tRNAHisGUG (5'-HisGUG) in macrophage biology, we specifically focused on these fragments to investigate its regulation during monocyte-to-macrophage differentiation and its role in macrophage survival. We performed small RNA sequencing during monocyte-to-macrophage differentiation using THP-1 cells and identified 5'-HisGUG as a prominently regulated tDR. Notably, transfection of 5'-HisGUG in macrophages decreased survival under apoptotic stress. We propose that 5'-HisGUG …

Figo Position Statement: Gamete Donations, Laurie Henry, Aris Antsaklis, Dov Feldberg, Jaideep Malhotra, Suchitra Pandit, Carlos Salazar, Alex Vidaeff, Rafal Zadykowicz, M Louise Hull, Nikhil Purandare

Faculty, Staff and Students Publications

Gamete donation has become a crucial part of Assisted Reproductive Technologies (ARTs), providing hope to individuals, including those who may have no other option for parenthood. This process comes with a wide range of ethical, medical, and legal challenges that need to be carefully addressed to protect the well-being and rights of all parties involved: donors, recipients, and offspring. Navigating these complexities requires strict ethical standards, robust regulatory frameworks, and international collaboration. By standardizing these, the field of gamete donation can continue to develop while ensuring that all parties are well informed and safeguarded. This paper explores the ethical concerns …

The Somatic Mosaicism Across Human Tissues Network, Tim H H Coorens, Ji Won Oh, Yujin Angelina Choi, Nam Seop Lim, Boxun Zhao, Adam Voshall, Alexej Abyzov, Lucinda Antonacci-Fulton, Samuel Aparicio, Kristin G Ardlie, Thomas J Bell, James T Bennett, Bradley E Bernstein, Thomas G Blanchard, Alan P Boyle, Jason D Buenrostro, Kathleen H Burns, Fei Chen, Rui Chen, Sangita Choudhury, Harsha V Doddapaneni, Evan E Eichler, Gilad D Evrony, Melissa A Faith, Thomas G Fazzio, Robert S Fulton, Manuel Garber, Nils Gehlenborg, Soren Germer, Gad Getz, Richard A Gibbs, Raquel G Hernandez, Fulai Jin, Jan O Korbel, Dan A Landau, Heather A Lawson, Niall J Lennon, Heng Li, Yan Li, Po-Ru Loh, Gabor Marth, Michael J Mcconnell, Ryan E Mills, Stephen B Montgomery, Pradeep Natarajan, Peter J Park, Rahul Satija, Fritz J Sedlazeck, Diane D Shao, Hui Shen, Andrew B Stergachis, Hunter R Underhill, Alexander E Urban, Melissa W Vondran, Christopher A Walsh, Ting Wang, Tao P Wu, Chenghang Zong, Eunjung Alice Lee, Flora M Vaccarino

Center on Aging Staff Publications

From fertilization onwards, the cells of the human body acquire variations in their DNA sequence, known as somatic mutations. These postzygotic mutations arise from intrinsic errors in DNA replication and repair, as well as from exposure to mutagens. Somatic mutations have been implicated in some diseases, but a fundamental understanding of the frequency, type and patterns of mutations across healthy human tissues has been limited. This is primarily due to the small proportion of cells harbouring specific somatic variants within an individual, making them more challenging to detect than inherited variants. Here we describe the Somatic Mosaicism across Human Tissues …

Coordinated Regulation By Lncrnas Results In Tight Lncrna-Target Couplings, Hua-Sheng Chiu, Sonal Somvanshi, Chung-Te Chang, Eric James De Bony De Lavergne, Zhaowen Wei, Chih-Hung Hsieh, Wim Trypsteen, Kathleen A Scorsone, Ektaben Patel, Tien T Tang, David B Flint, Mohammad Javad Najaf Panah, Hyunjae Ryan Kim, Purva Rathi, Yan-Hwa Wu Lee, Sarah E Woodfield, Sanjeev A Vasudevan, Andras Attila Heczey, M Waleed Gaber, Gabriel O Sawakuchi, Ting-Wen Chen, Pieter Mestdagh, Xuerui Yang, Pavel Sumazin

Faculty, Staff and Student Publications

The determination of long non-coding RNA (lncRNA) function is a major challenge in RNA biology with applications to basic, translational, and medical research. We developed BigHorn to computationally infer lncRNA-DNA interactions that mediate transcription and chromatin-remodeling factor activity. Its accurate inference enabled the identification of lncRNAs that coordinately regulate both the transcriptional and post-transcriptional processing of their targets. These lncRNAs may act as molecular chaperones, regulating the stability and translation of mRNAs they helped transcribe, leading to tightly coupled expression profiles. Our analysis suggests that lncRNAs regulate cancer genes across tumor contexts, thus propagating the effects of non-coding alterations to …

July 2025, Swosu Rural Health Center

RURAL ROCKS

July 2025 Rural Rocks

• Three Ways Tech Can Help
• Can a Face Mask Diagnose Kidney Disease?
• EXTRA - Chronic Kidney Disease
• Pharmacy Technicians as Community Health Workers Pilot Program in Oklahoma

The Fiscal Deficit And National Debt: Can We Get It Right Once And For All?, Jesus Felipe, Mariel Monica Sauler

Angelo King Institute for Economic and Business Studies (AKI)

No abstract provided.

Blue Light Is A Key Factor In Regulating Stomatal Movement, Transpiration Rate And Aba Metabolism Under Varying Vapour Pressure, Sheona Noemi Innes, Sara Brunborg Jakobsen, Rikke Bryn Røsåsen, Haider Ali, Knut Asbjørn Solhaug, Jorunn Elisabeth Olsen, Sissel Torre

Research outputs 2022 to 2026

Vapour pressure deficit (VPD) and blue light (BL) are import signals for stomatal regulation and highly relevant during cultivation of economically important crops such as cucumber in controlled environments. However, the information about combined effects of VPD and BL and the regulation of abscisic acid (ABA) in this respect, is limited and seems to vary between species. This study investigated how moderate (1.12 kPa) or low (0.28 kPa) VPD combined with 5% or 30% BL affect the foliar ABA metabolism, transpiration rate, nutrient uptake, and growth in well-watered cucumber plants (Cucumis sativus ‘Quatro’). Additional BL, regardless of VPD, resulted in …

The Effectiveness Of University Administration In Performing The Function Of Community Service: Enhancing Lifelong Learning Opportunities As A Model In The Saudi Context, Abdullah Dhaifallah Alharthi

Journal of Educational and Psychological Studies

we would like to inform you that the current study aimed to determine the degree of effectiveness of university administration in performing its function in serving the community in order to improve lifelong learning opportunities in the dimensions of availability and diversity. the thesis also aimed to determine effectiveness, access and dissemination, and the researcher used the descriptive approach, relying on the questionnaire as a tool to collect data that he collected according to the facilitated sample, which numbered (2048) individuals from the saudi community in the first semester of the academic year 2024. the study extracted a number of …

The Effect Of Integrating Augmented Reality (Ar) Technology In Science Education Teaching On Improving The Biological Concepts Learning Among Kindergarten Children, Kawthar Habeeb

Journal of Educational and Psychological Studies

This quasi-experimental study explored the impact of AR on acquiring biological concepts among kindergarteners. The sample comprised 30 second-level kindergarteners from a school in Farwaniya Educational Directorate, Kuwait. Participants were randomly divided into an experimental group (n = 15), taught using AR, and a control group (n = 15), taught traditionally. Results revealed statistically significant di erences in biological concept understanding, favoring the experimental group. Additionally, the experimental group demonstrated significant improvement from pre-test to post-test stages. These findings highlight the potential of AR to enhance learning outcomes in kindergarten biology education. The study emphasizes the importance of integrating AR …

Nantucket Eelgrass Management Plan, Kimberly Starbuck, Kristin Uiterwyk, Shannon Hogan

Urban Harbors Institute Publications

Eelgrass is a critical component of our coastal ecosystem, supporting marine biodiversity, improving water quality, and helping to stabilize the shoreline. This planning effort aims to support the long-term health and sustainability of eelgrass habitats in our local waters.

Eelgrass (Zostera marina L.) is a subtidal seagrass found on both the east and west coasts of North America. Over the last 40 years, eelgrass has declined worldwide as a result of increased turbidity, algal blooms, physical disturbances, disease, and a host of other stressors. Specifically, in Massachusetts, the eelgrass population has declined approximately 50% in the last 30 …

L-Quebrachitol Modulates The Anti-Convulsant Effects Of Carbamazepine Possibly Through Voltage-Gated Sodium Channel Blocking Mechanism In Chicks: In Vivo And In Silico Studies, Asifa Asrafi, Mohammad Aslam, Ali G. Alkhathami, Md. Sakib Hossain, Imam Hossen Rakib, Md. Sakib Al Hasan, Feroz Khan Nun, Md. Faisal Amin, Muhammad Torequl Islam

School of Integrative Biological & Chemical Sciences Faculty Publications

Introduction: L-Quebrachitol (LQB), a naturally occurring bioactive compound, exhibits anti-inflammatory, anti-oxidant, anti-cancer, and anti-diabetic properties. However, its therapeutic potential in convulsant management remains largely unexplored. The objective of this study was to investigate the anticonvulsant effects of LQB in an In Vivo model and to examine its molecular interactions via In Silico docking simulations.

Methods: In the In Vivo study, pentylenetetrazol (PTZ) was administered intraperitoneally (i.p.) at 80 mg/kg to induce convulsions, and the test animals were treated orally with three doses of LQB (1, 5, and 10 mg/kg), with carbamazepine (CBZ) at 80 mg/kg as a standard drug.

Results: …

Towards Efficient Privacy-Preserving Deep Learning: He-Friendly Structures, Flexible Pruning, He-Efficient Architectures, And Secure Transformer Token Drop, Yifei Cai

Electrical & Computer Engineering Theses & Dissertations

Deep learning (DL) has become a powerful tool for solving complex problems, but developing DL models typically requires vast datasets, high computational resources, and expert knowledge—barriers that limit accessibility. Machine Learning as a Service (MLaaS) addresses this challenge by allowing resource-rich providers to deliver pre-trained DL models as services. However, privacy concerns arise: clients hesitate to share sensitive data, while providers protect their proprietary models. To address this, privacy-preserving MLaaS integrates cryptographic techniques into DL computations, as seen in frameworks like Cryptonets, SecureML, GAZELLE, CrypTFlow2, Cheetah, and BOLT. Among them, Homomorphic Encryption (HE) enables computation on encrypted data but remains …

Assessment Of Preoperative Factors In Relation With Difficulty Of Laparoscopic Cholecystectomy, Ahmed Nayyef, Hayder Alkawaz

Iraqi Postgraduate Medical Journal

IntroductionLaparoscopic cholecystectomy is the gold standard for treatment of gallbladder diseases It is relatively a simple and quick procedure, but it can be difficult, and needs special instruments and an experienced surgeon. Moreover, in specific situations, conversion from laparoscopic to open approach is still required. However, identifying the preoperative patient-related factors, and anticipating the need to convert from laparoscopic cholecystectomy to open surgery can help identifying high-risk patients and redefine the surgical strategy needed Aim:Assessing laparoscopic cholecystectomies, by identifying the preoperative factors that predict the difficulty of laparoscopic cholecystectomy.Patients and MethodA prospective cross-sectional study conducted in Al Yarmouk Teaching Hospital …

Varied Legal Parameters Shape Fiduciaries’ Ability To Act On Climate Risk, Cynthia Hanawalt, Andy Fitch

Sabin Center for Climate Change Law

Commentators who advocate either for or against corporate and asset managers addressing climate risks often refer to “fiduciary duty” as justification for their claims. Yet no field of corporate or asset management actually imposes one standalone fiduciary duty. Nor do any two business-law fields impose the same fiduciary regime. Instead, these fields adopt differing arrays of fiduciary duties to address various types of relationships, comprising a different blend of affirmative obligations and/or prohibitions, assessed with different degrees of strictness by enforcers and courts. As a result, overgeneralizations about fiduciaries’ duty in all business-law contexts tend to further obscure what a …

Mutualistas: La Sociedad Auxiliar De Mutua Beneficiaria, Antonito Colorado, 1937-1994, José A. Rivera Ph.D

Faculty Publications

Mutual Aid Societies proliferated in the American Southwest during a period of rapid social change, 1880-1930. In Hispanic towns, these societies were referred to as mutualistas, with a large number concentrated in the San Luis Valley of Colorado and rural counties of northcentral New Mexico. One of the men’s organizations, La Sociedad Protección Mutua de Trabajadores Unidos (SPMDTU), started in Antonito, Colorado, and quickly spread to other communities of southern Colorado and northern New Mexico and eventually to a few mining towns in Utah. With a tri-state model in place, women formed their own mutual protection societies: Sociedad Protectora …

A Comprehensive Study Of Library-Led Textbook Affordability Initiatives In The United States, Mitchell Scott, Rachel E. Scott

Faculty and Staff Publications – Milner Library

This study presents findings from a survey and interviews investigating library-led textbook affordability initiatives in the United States. The results document diverse considerations and divergences in workflows, challenges librarians face in establishing and maintaining textbook affordability programs, and the intersection of these initiatives with library and institutional strategies. Findings suggest that these programs have grown in number and scale over the past few years, accelerated by the COVID-19 pandemic lockdowns, and are sustained—even without permanent, designated funding—due to consistently positive perceptions about their impact on student success, just-in-time delivery, and alignment with library and institutional goals.

Benjamin Ferencz In The Cold War, Noah Weisbord

Cardozo International & Comparative Law Review

The article explores Benjamin Ferencz's advocacy for international law and his role in shaping the legal frameworks of the post-World War II era, particularly his efforts to define aggression and establish the International Criminal Court. It contrasts Ferencz's idealism with the pragmatic approaches of Henry Kissinger and the diplomatic strategies of Dag Hammarskjold, highlighting the challenges of the Cold War international order and its failure to address individual threats, exemplified by A.Q. Khan's nuclear proliferation.

Furthering The Legacy Of Benjamin B. Ferencz: Amending The Rome Statute’S Jurisdiction Over The Crime Of Aggression, Jennifer Trahan

Cardozo International & Comparative Law Review

The article advocates for amending the Rome Statute to strengthen the International Criminal Court's (ICC) jurisdiction over the crime of aggression. It argues that the current jurisdictional regime, established by the 2010 Kampala amendments, is too limited, creating double standards and undermining the rule of law. The author calls for harmonizing the ICC's jurisdiction over the crime of aggression with its jurisdiction over other crimes, such as genocide and war crimes, to ensure consistent and universal accountability.

The Unique Function Of The Crime Against Humanity Of Other Inhumane Acts In The Progressive Development And Codification Of International Criminal Law, David Donat Cattin

Cardozo International & Comparative Law Review

The article explores the evolution and role of "other inhumane acts" as a residual category within the definition of crimes against humanity, tracing its development from the Nuremberg trials through the Rome Statute of the International Criminal Court (ICC). It highlights the potential of this category to adapt to new forms of atrocities and discusses the challenges and opportunities in aligning future treaty developments with existing legal frameworks.

Exceptions To The International Customary Law Rule On Head Of State Immunity Under International Criminal Law, Daniel D. Ntanda Nsereko

Cardozo International & Comparative Law Review

The article examines the tension between head of state immunity and the pursuit of justice in international criminal law. It argues that while some nations and regional bodies, like the African Union, assert immunity for heads of state, international institutions such as the International Criminal Court (ICC) reject this principle, emphasizing the rule of law and accountability. The ICC's jurisdiction, particularly through UN Security Council referrals, overrides state consent, challenging traditional notions of immunity. The article posits that states must adhere to their treaty obligations, such as the Rome Statute, and cannot unilaterally opt out for political expediency, reinforcing the …

No More Mixed Message, Missing Money: Revisiting The Birth Of Icl’S Victim Restoration-Reparations Regime To Conceptualize Its Modern Reform, Gregory S. Gordon

Cardozo International & Comparative Law Review

The article argues that the International Criminal Court's (ICC) system for victim reparations is fundamentally flawed due to mission dissonance between its punitive and restorative goals, insufficient funding, and procedural limitations. It proposes the creation of an independent Atrocity Victim Reparations Tribunal (AVRT) under the UN to address these issues, ensuring more effective and victim-centered reparations.

Secure Query On Encrypted Data By Using Fully Homomorphic Encryption, Mrinmoy Bera

Master’s Dissertations

Cloud service providers typically store user data in an encrypted form (data at rest). However, when a user performs a query, the server first decrypts the data, processes the query on plaintext, and then sends the result back to the user (data in transit). This process exposes a critical vulnerability—if the cloud server is ever compromised, the decrypted data becomes accessible to the attacker. To address this security gap, we design a secure query protocol that eliminates the need to decrypt data on the server side. Fully Homomorphic Encryption (FHE) offers a groundbreaking solution by enabling arbitrary computations directly on …