Digital Commons Network^™

A Comparison Of Different Posterior Arthrodesis Techniques Versus Anterior Dens Screw For Odontoid Fractures: A Systematic Review And Meta-Analysis, Pavlos Texakalidis, Stavros Matsoukas, Michael Cloney, Mykhaylo Krushelnytskyy, Kevin Swong, Najib El Tecle, Tyler Koski, Nader Dahdaleh

Department of Neurosurgery Faculty Papers

BACKGROUND AND OBJECTIVES: Odontoid fractures are often managed surgically. The most common approaches are anterior dens screw (ADS) and posterior arthrodesis (PA), with the latter being associated with significantly higher fusion rates. PA techniques can include wiring, C1-C2 transarticular (TA) screws, and C1 lateral mass (LM)-C2 pars/pedicle screws. Most comparative studies group multiple PA techniques together when comparing PA versus ADS. Our objective was to systematically review the literature and identify studies that separately provide fusion rates of each different posterior C1-C2 arthrodesis (PA) technique utilized compared to ADS.

METHODS: A systematic literature review was conducted according to the Preferred …

Factors Related To Hypertension In Pediatric Patients Who Do Not Have Obstructive Sleep Apnea: A Retrospective Chart Study, Alyssa Exarchakis, Alexandra Cohen, Penghao Wang, Seema Rani, Diana Martinez

Department of Medicine Faculty Papers

Background/Objectives: The relationship between OSA and adult hypertension has been extensively studied; however, it remains understudied in pediatric patients without OSA. The aim of this study is to identify factors associated with pediatric hypertension without OSA, through an IRB-approved retrospective chart review of patients who underwent polysomnography at Nemours Children's Hospital, DE/NJ between January 2020 and July 2023. Methods: Eligibility criteria included children 8-17 years, completed PSG, and clinic visit blood pressure (BP). Anthropometrics, demographics, social determinants, and medical history were obtained from electronic medical records. Hypertension was defined as the average systolic and/or diastolic BP that is …

Amino Acid Transporter Lat1 (Slc7a5) Promotes Metabolic Rewiring In Tnbc Progression Through The L-Trp/Qprt/Nad+ Pathway, Margot Y. Fedoroff, Lei Zhao, Shaomin Wang, Alok Bhushan, Haifeng Yang, Karen M. Bussard, Stephen C. Peiper, Jun He

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Cancer cells uptake excessive nutrients by expressing higher levels of glucose and/or amino acid transporters to meet their increased energy demands. L-type amino acid transporter 1 (LAT1), is regarded as a cancer-specific transporter for the uptake of large neutral amino acids such as L-tryptophan. However, the mechanism by which LAT1 rewires cellular metabolism to promote cancer progression and chemoresistance have not yet been investigated.

METHODS: The protein levels of LAT1, p-PKM2, and p-LDHA were determined in breast cancer tissue arrays by immunohistochemistry staining followed by survival analysis. The orthotopic breast cancer models in mice, syngeneic breast cancer models, and …

Our Ethical Duty: Assessing The Competencies Of Counselors-In-Training For Counseling With Transgender And Gender Expansive Clients, Deanna N. Cor, M. N. Saltis, Megan Doughty Shaine, Lauren Streeter

Counselor Education Faculty Publications and Presentations

Counselors report a lack of competence in working with transgender and gender expansive (TGE) individuals. TGE people report a lack of competent and affirming care. This study used the Gender Identity Counselor Competency Scale- Revised (GICCS-R) to understand self-reported competence and training levels in working with this population. Participants were 90 masters-level counselors in training who had at least started practicum in CACREP-accredited programs. Hierarchical linear regression was utilized to determine factors that predict competence including identities and training levels. Results highlight a lack of perceived competence in skill-based training. Counselor education programs must focus on improving TGE affirmative skills.

Deployable Systems Eat, Utah State University Space Dynamics Laboratory

Space Dynamics Laboratory Publications

What Are Mechanisms?

• Moving Mechanical Assembly (MMA)

• A device that controls the movement of a deployable or other movable system of a space or launch vehicle

• Why do mechanisms exist?

• 1) Fit within launch vehicle or dispenser
• 2) Stow for launch loads
• 3) Change position or pointing once on orbit
• 4) Deploy objects

Synthesis And Evaluation Of Novobiocin Analogues As Potential Inhibitors Of Polymerase Theta Polθ In Dna Damage And Repair, Mohammed Essam Albuhluli

Theses and Dissertations

Killing tumors while leaving normal cells unharmed is the goal of precision cancer therapy, a challenging feat that is enabled by targeting tumor-specific vulnerabilities [1]. Targeting Polθ potentiates PARP inhibitors (PARPi) in specifically killing homology-directed repair (HDR)-deficient tumor cells and re-sensitize PARPi resistant tumor cells [1]. The induced essentiality between Polθ and HDR-deficiency underscores the value of Polθ as a therapeutic target in the context of tumors with HDR genetic mutations [1]. The helicase-like domain (HLD) is a super family 2 (SF2)-type domain with DNA-dependent ATPase activity [1]. We previously discovered that the antibiotic NVB acts as an inhibitor of …

Third To Fifth-Grade Teachers’ Challenges When Teaching Reading Comprehension Skills To English Language Learners In Northern Virginia, Lorraine A. Wickham-Ellis

Walden Dissertations and Doctoral Studies

Third to fifth-grade teachers in a Northern Virginia Title 1 elementary school faced challenges when teaching reading comprehension skills to English language learners (ELLs) which impacted ELLs’ performance on state-mandated tests. Framed by Cummins’s second language acquisition theory, the purpose of this basic qualitative study was to explore third to fifth-grade teachers’ challenges in teaching reading comprehension skills to ELLs and their suggestions for improved training and resources in a Northern Virginia Title 1 elementary school. Two research questions addressed the teachers’ challenges and suggestions for improved training and resources. Semistructured interviews were used to collect qualitative data from nine, …

Intersectionality Gaps Among Multiple Social Determinants In U.S. Infant And Maternal Mortality Rates, Mary D. Kirkley

Walden Dissertations and Doctoral Studies

The purpose of this quantitative, cross-sectional study was to examine whether social determinants interactively influence U.S. maternal and infant mortality rates. Grounded in the Social Ecological Model, this study analyzed secondary data from the Centers for Disease Control and Prevention’s National Vital Statistics System were analyzed using multivariable logistic regression. The final sample included 110,402 maternal deaths and 55,839 infant deaths, with inclusion criteria requiring complete data on race, education, age, marital status, gender (for infants), residency, and year of death. Exclusion criteria included non-U.S. resident deaths or missing demographic data. Results revealed statistically significant interaction effects: race/ethnicity with education …

Genome-Wide Association Study For Lung Cancer In 6531 African Americans Reveals New Susceptibility Loci, Jinyoung Byun, Younghun Han, Jiyeon Choi, Ryan Sun, Vikram R Shaw, Catherine Zhu, Xiangjun Xiao, Christine Lusk, Hoda Badr, Hyun-Sung Lee, Hee-Jin Jang, Yafang Li, Hyeyeun Lim, Erping Long, Yanhong Liu, Linda Kachuri, Kyle M Walsh, John K Wiencke, Demetrius Albanes, Stephen Lam, Adonina Tardon, Marian L Neuhouser, Matt J Barnett, Chu Chen, Stig Bojesen, Hermann Brenner, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeböller, David C Christiani, Gad Rennert, Susanne Arnold, John K Field, Sanjay Shete, Loic Le Marchand, Geoffrey Liu, Angeline S Andrew, Shanbeh Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Fiona Taylor, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Alpa Patel, Xihong Lin, Krista A Zanetti, Curtis C Harris, Stephen Chanock, James Mckay, Ann G Schwartz, Rayjean J Hung, Christopher I Amos

Faculty, Staff and Student Publications

Despite lung cancer affecting all races and ethnicities, disparities are observed in incidence and mortality rates among different ethnic groups in the United States. Non-Hispanic African Americans had a high incidence rate of lung cancer at 55.8 per 100 000 people, as well as the highest death rate at 37.2 per 100 000 people from 2016 to 2020. While previous genome-wide association studies (GWAS) have identified over 45 susceptibility risk loci that influence lung cancer development, few GWAS have investigated the etiology of lung cancer in African Americans. To address this gap in knowledge, we conducted GWAS of lung cancer …

Guidance & Counseling Services For Students Special Needs In The Organizer School Inclusive Education In Dki Jakarta Region, Marja Marja, Trisna Mulyeni, Irah Kasirah, Widia Kusuma Dewi

Journal of ICSAR

This study examines the implementation of guidance and counseling (BK) services for students with special needs (ABK) in inclusive public schools in the DKI Jakarta region. Although inclusive education policies have been adopted nationally, the provision of structured psychosocial and academic support through counseling remains inconsistent across schools. Using a qualitative descriptive approach, this research involved twelve inclusive schools and collected data through interviews, observations, and document analysis. Participants included BK teachers, homeroom teachers, and school principals. Thematic analysis was conducted to identify patterns in the design, delivery, and impact of counseling services for ABK students. The findings indicate that …

Implementation Of Inclusive Education In Elementary Schools In Balikpapan City: Challenges, Solutions, And Impacts, Firman Firman, Ganjar Susilo, Tri Astuti Nur’Aini

Journal of ICSAR

The goal of implementing inclusive education in schools is to guarantee that every student, including those with special needs, receives a high-quality education. This research seeks to evaluate how inclusive education is being carried out in primary schools (SD) in Balikpapan City, with a focus on the challenges faced, solutions proposed, and the effects on student development. A descriptive qualitative method was employed, utilizing observation, interviews, and documentation techniques. Data analysis followed Miles and Huberman's framework, involving data description, analysis, and drawing conclusions. The findings indicate that inclusive education in Balikpapan City's elementary schools holds significant potential to transform the …

The Integrative Model For Strengthening The Quality Of Inclusive Education Based On Digital Literacy, Achievement Culture, And Teacher Work Motivation, Listyowati Listyowati, Maryanto Maryanto, Ngasbun Egar

Journal of ICSAR

This study aims to develop an integrative model to enhance the quality of inclusive education based on digital literacy, achievement-oriented school culture, and teacher work motivation at public elementary schools in the Candisari District, Semarang City. A quantitative approach was employed using survey methods and path analysis. Data were collected from 105 teachers through closed-ended questionnaires and analyzed using multiple linear regression and path analysis. The results revealed that all three independent variables had a significant positive effect on the quality of inclusive education. Moreover, digital literacy and achievement culture indirectly influenced quality through teacher motivation as a mediating variable. …

Collaboration Between Special Education Teachers And Inclusive Teachers In Aceh Province, Teguh Shulha Shidqi, Rahmahtrisilvia Rahmahtrisilvia

Journal of ICSAR

This study examines collaboration between special education teachers and teachers in schools of inclusive education in Aceh Province. Using a qualitative approach with the scoping review method and prism protocol, this study analyses the relevant literature of published scientific journals. Data search was conducted on Google Scholar using the Harzing's Publish or Perish application, 3 articles were obtained for further analysis. The research results showed that collaboration between SLB teachers and teachers in inclusive schools in Aceh Province was not optimal. The implementation of inclusive education in Aceh still faces challenges such as not yet constructed cultural and strong policies, …

Building Quality Inclusive Schools Through Transformational Leadership, School Culture, And Digitalization: An Empirical Study In Public Elementary Schools In Tugu District, Semarang City, Munirotun Munirotun, Widya Kusumaningsih, Nurkolis Nurkolis

Journal of ICSAR

This study investigates the influence of transformational leadership, school culture, and digitalization on the quality of inclusive elementary schools in Tugu District, Semarang. As the foundation of national development, education requires not only knowledge transfer but also the cultivation of character and values. Despite being categorized as “Good,” most elementary schools in Tugu District have experienced a decline in learning quality, as indicated by the 2023 national assessment. Key challenges include teacher shortages, competency mismatches, excessive workloads, and limited understanding of the Merdeka Curriculum. Additional obstacles such as high administrative burdens and inadequate digital infrastructure further impede effective learning. Employing …

A Quantitative Study On The Determinants Of Collaborative Culture In Inclusive Primary Schools: The Role Of Social Competence, Work Motivation, And Organizational Climate, Angela Astrid Stelladiba Cindy Ayu, Bunyamin Bunyamin, I Made Sudana

Journal of ICSAR

This study aims to examine the influence of teachers’ social competence, work motivation, and organizational climate on collaborative culture in elementary schools within the Bawana Alit cluster, Tembalang District, Semarang City. Employing a quantitative approach with a correlational design, data were collected through questionnaires distributed to 153 teachers selected using proportional random sampling. The data were analyzed using descriptive statistics, multiple regression analysis, and hypothesis testing. The results showed that each independent variable social competence (r = 0.701), work motivation (r = 0.726), and organizational climate (r = 0.821) had a positive and significant influence on collaborative culture. Simultaneously, the …

Determining Graduate Quality Through School Principals’ Transformational Leadership, Teachers’ Professional Competence, And Work Motivation: A Quantitative Study, Ana Supriati, Titik Haryati, Sumarno Sumarno

Journal of ICSAR

This study aims to analyze the influence of school principals’ transformational leadership, teachers’ professional competence, and work motivation on the quality of graduates in public junior high schools in Rembang Regency. A quantitative approach was employed using a survey method involving 289 teachers as respondents. The research instrument used a Likert-scale questionnaire tested for validity and reliability. Data were analyzed using multiple linear regression techniques. The results revealed that both partially and simultaneously, the three independent variables had a positive and significant influence on the quality of graduates. Transformational leadership fosters a supportive school climate, professional competence enhances teaching effectiveness, …

Optimization Of Participation Path Of Trade Union Organizations In Social Co-Governance Of Food Safety, Xu Chaofan

Food and Machinery

In the context of China's social co -governance of food safety,advancing the participation of trade union organizations plays a significant role in enhancing workers' professional quality through education and training,and strengthening corporate responsibility through collective bargaining.Although notable progress has been made in current practices,challenges still exist,including the relatively simple form of popular science education,the insufficient effectiveness of new media publicity,and the inadequate support for workers' food safety reporting by trade union organizations.To address these challenges,solutions should be explored from multiple perspectives:diversifying public science education methods,forming a full -media publicity strategy for trade unions in food safety co -governance,and improving support …

Preparation And Structural Analysis Of Antioxidant Peptides From Tilapia Skin By Microwave-Assisted Enzymatic Hydrolysis, Mi Chunxiao, Zhou Hui, Hu Xingyuan, Zhu Wanting, Wu Long

Food and Machinery

［Objective］ To prepare antioxidant peptides from tilapia skin by microwave -assisted enzymatic hydrolysis and conduct structural analysis.［Methods］ The processing conditions for preparing antioxidant peptides by microwave pretreatment -assisted alkaline protease hydrolysis are optimized through single -factor and response surface experiments,and the effects of microwave treatment on the structure of fish skin,the relative molecular weight,amino acid composition,and antioxidant activity of antioxidant peptides are analyzed.［Results］］ The optimal processing conditions for preparing antioxidant peptides by microwave -assisted enzymatic hydrolysis are as follows:microwave power of 441.50 W,microwave temperature of 61.00 ℃,microwave time of 20 min,hydrolysis time of 6.21 h,enzyme dosage of 2.20%,and solid -to-liquid …

The Use Of Burt’S Method In Rationalizing The Cost Of Time And Evaluating The Performance Companies: An Applied Study In State Company For Textile And Leather Industries - Hilla Textile Factory, Aqeel Jaber Kadhim

Muthanna Journal of Administrative and Economics Sciences

Burt’s method is a significant process research method that provides information that directly affects the scheduling process of complex projects and planning and monitoring their completion. As a result, it has gained notoriety among practitioners in the field of specialization and offers additional advantages through computer systems for completion. It seeks to finish the project as quickly as possible while using the resources and capabilities that are available and at the lowest feasible cost. The evaluation of the performance of companies is represented in the extent of the ability of the company’s management to evaluate the performance of its activities …

Enhancing Thematic Learning Outcomes And Reducing Maladaptive Behaviors In Autistic Students Through The Busy Web Media, Hartini Nara, Rohmah Ageng Mursita, Ashi Thariq Jaatshiah

Journal of ICSAR

This study aims to develop Busy Web Media as a tool for thematic learning, designed to reduce maladaptive behaviours in autistic students in grade VI at Sekolah Matahari Bunda. Using the Research and Development (R&D) method in conjunction with the ADDIE model (Analysis, Design, Development, Implementation, Evaluation), the study involved expert evaluations at various stages. Media experts, content specialists, and autism experts provided their assessments, with all evaluations indicating high feasibility. Specifically, the media expert rated the product positively, emphasising its design and usability. The subject matter expert found the content highly appropriate for the curriculum, and the autism expert …

The Influence Of Learning Communities, Work Ethic, And Achievement Motivation On Teacher Professional Competence: A Quantitative Study In Public Elementary Schools In Candisari District, Semarang City, Fina Febriyanti, Maryanto Maryanto, Ngasbun Egar

Journal of ICSAR

One of the key determinants of educational quality is the professional competence of teachers, which directly impacts student achievement and the overall standard of education. This study examines the influence of learning communities, work ethic, and achievement motivation on the professional competence of elementary school teachers in Candisari District, Semarang. Recent performance evaluations indicate that teachers’ professional competence remains lower than other competencies, highlighting the need for targeted improvement. Learning communities serve as collaborative platforms for teachers to share experiences and solve instructional challenges, especially relevant with the implementation of the Merdeka Curriculum, which demands greater flexibility and student-centered approaches. …

Toward Inclusive Higher Education: Challenges And Opportunities In Ten Asian Countries Following Crpd Ratification, Mohammad Idrees Naeemy, Hiroki Yoneda

Journal of ICSAR

The ratification of the Convention on the Rights of Persons with Disabilities (CRPD) has triggered a wave of policy initiatives aimed at inclusive higher education around the world. Yet the extent of progress remains unclear in Asian region. This systematic review fills that gap by analysing 46 peer-reviewed publications (2013–2024) that document post-CRPD developments in ten Asian countries—China, India, Iran, Japan, Kazakhstan, Malaysia, Pakistan, Singapore, Turkey and the United Arab Emirates. We mapped legislative reforms, organizational responses and structural adaptations designed to accommodate students with disabilities and compared the pace and depth of change across national contexts. The review revealed …

Digital Menstrual Health Education For Adolescent Girls With Intellectual Disabilities: Evidence From The Kesmens Digital Media Intervention, Ana Fatimatuzzahra, Endang Rochyadi, Riksma Nurhami Akhlan, Een Ratnengsih, Mughi Puspa Annisi

Journal of ICSAR

Adolescent female with intellectual disabilities often encounter substantial barriers in managing menstrual hygiene, which may negatively impact their physical health, social integration, and personal autonomy. These challenges are largely attributed to the absence of concrete and developmentally appropriate educational tools, along with limited support from families and educators during menstruation. This study evaluates the effectiveness of the KESMENS Digital Book, a family assisted multimedia learning resource, in improving menstrual hygiene management skills among adolescents with intellectual disabilities. Using a Single Subject Research method with an A B design, the intervention was implemented for a junior high school student at SLBN …

Collaborative Strategies In Self-Protection Against Sexual Violence For Children With Intellectual Disabilities: Systematic Literature Review, Zulfa Rahmah Effendi, Endang Rochyadi, Budi Susetyo, Oom Sitti Homdijah

Journal of ICSAR

This study explores collaborative strategies based on the Pentahelix model to enhance self-protection education against sexual violence for children with intellectual disabilities. Recognizing the heightened vulnerability of this population and the fragmented nature of existing protective mechanisms, this research adopts a Systematic Literature Review (SLR) method guided by PRISMA protocols. A total of 25 peer-reviewed, Scopus-indexed articles published between 2015 and 2024 were thematically analyzed. The findings reveal that multi-actor collaboration involving government, academia, communities, the private sector, and media plays a pivotal role in establishing responsive protection systems and educational interventions tailored to the specific needs of children with …

Assessing Significance Of Inclusive Education As A Remedy Of Addressing The Challenges Of Disabled Children, Sive Makeleni, Onyinyechi Glory Ndu

Journal of ICSAR

The issue of disability in the lives of many children has raised a lot of debates by scholars in terms of their learning ability and meeting immediate needs. This study focuses on the inclusive education for dealing with special needs of children. It aimed at assessing the significance of inclusive education and training as a remedy for addressing the challenges facing the disabled children in dealing with their special needs. What their immediate needs are, and finally suggest measures to put in place in addressing the identified problems. The study employed a literature review method. The data was collected using …

Holistic Approach In Inclusive Education Management In Indonesia: A Systematic Review Of Strategies And Challenges Faced By Schools, Bayu Pamungkas, Angga Damayanto, Adi Suseno

Journal of ICSAR

This study aims to analyze the strategies and challenges faced by schools in implementing inclusive education management in Indonesia. The method employed is a Systematic Literature Review (SLR) conducted in accordance with the PRISMA guidelines. The results show that schools in Indonesia have implemented various strategies to support inclusive education, including curriculum adaptation, teacher professional development, collaboration with stakeholders, provision of facilities and infrastructure, utilization of technology, and holistic approaches. However, challenges such as lack of understanding and support, limited resources, and difficulties in developing adaptive curricula and inclusive learning methods still exist. This research highlights the importance of collaborative …

Deep Learning For Personalized Learning: Tailoring Curriculum To Student Needs, Muh. Fihris Khalik, Ardi Azhar Nampira

Journal of ICSAR

The technological transformation of the digital era has significantly reshaped the educational landscape, driving a shift toward more personalized learning approaches. This study explores the integration of deep learning technologies in tailoring curriculum to meet the individual needs of students. Using a qualitative literature review, it examines how deep learning can identify learning behavior patterns, assess students' strengths and weaknesses, and deliver timely and relevant instructional interventions. The findings suggest that personalized learning powered by artificial intelligence (AI) and adaptive curricula can enhance student motivation, learning effectiveness, and inclusivity. However, the implementation also poses challenges, including concerns over data privacy, …

Innovation And Quality Of Teacher Training In The Transformation Of Special Education Toward Inclusive Learning In The Sdgs Era, Vasas Elkasih Lase, Fariyeni Fariyeni, Dessy Masita, Teguh Shulha Shidqi, Elsa Elfrina

Journal of ICSAR

To achieve the Sustainable Development Goals (SDGs), particularly Goal 4 on inclusive and equitable education, the transformation of special education into high-quality inclusive learning is crucial. One key aspect of this transformation is teacher training and the quality of teaching services. Although inclusive education policies have been implemented inany schools, challenges remain regarding teacher preparedness and the contextual relevance of training. This study investigates how teachers and school leaders in special schools (SLB) understand and implement inclusive education transformation within a changing socio-cultural context. This research uses a qualitative case study approach, involving participant observation, semi-structured interviews, and document analysis …

Testosterone Deficiency And Treatments: Common Misconceptions And Practical Guidance For Patient Care, Mohit Khera, James M Hotaling, Martin Miner

Faculty, Staff and Students Publications

Introduction: Misconceptions about testosterone therapy are prevalent and there is an unmet need for a review of current literature that can be leveraged by physicians to deliver safe and effective care for men with hypogonadism.

Objectives: This review aims to address common misconceptions about testosterone therapy using current literature and synthesize practical guidance for clinicians with patients who are starting testosterone therapy.

Methods: A literature search of PubMed, Embase, CINAHL was carried out to identify associations between testosterone therapy and prostate cancer, cardiovascular risk, and hepatic toxicity; definitions of hypogonadism; and practical guidance for clinician with patients starting testosterone therapy. …

Direct Inhibition Of Ras Reveals The Features Of Oncogenic Signaling Driven By Ras G12 And Q61 Mutations, Michelangelo Marasco, Dinesh Kumar, Santiago Garcia Borrego, Tessa Seale, Giulia Maddalena, Riccardo Mezzadra, Kylie Belanger, Soren Cole, Brayan Perez, Wei Luan, Radha Mukherjee, Ilinca Aricescu, Vladimir Markov, Yuxin Zhu, Sabrina Arena, Alberto Bardelli, Elisa De Stanchina, Scott W Lowe, Richard A Burkhart, Jacquelyn W Zimmerman, Rona Yaeger, Scott E Kopetz, Neal Rosen, Sandra Misale

Faculty, Staff and Student Publications

RAS genes are frequently mutated in cancer, often at codons 12 and 61. With the recent introduction of RAS inhibitors, we can now directly investigate the effects of specific RAS mutations in cancer cells. In this study, we demonstrate that in tumors with RASG12X mutations, mutant RAS can be activated by receptor tyrosine kinases (RTK), and PI3K activation is dependent on mutant RAS. Conversely, RASQ61X mutations activate the MAPK cascade independently of RTKs, and inhibition of RASQ61X impairs MAPK pathway activation but leaves the PI3K pathway unaffected. Our characterization of these distinct features of G12X and Q61X mutations suggests that …