Digital Commons Network^™

Evaluating Nutrition, Exercise, And Education, On Mental Health And Quality Of Life In Menopause, Jill R. Stone

Walden Dissertations and Doctoral Studies

Physical inactivity, poor nutrition, and a lack of understanding of menopause adversely affect mental health and quality of life in women entering menopause. Metabolic changes during this period can lead to an increase in visceral fat, loss of muscle mass, depression, and anxiety. These metabolic changes are linked to a higher risk for cardiovascular disease, type two diabetes, and metabolic syndrome. This cross-sectional quantitative study, guided by the health belief model, explored the contribution of adopting specific nutrition strategies, exercise, and education in women during menopause transition to help manage mental health (as measured by depression and tension), and quality …

Environmental Exposures Increase Health Risks In Childhood Cancer Survivors., Omar Shakeel, Nicole Wood, Hannah M. Thompson, Michael E. Scheurer, Mark D. Miller

Manuscripts, Articles, Book Chapters and Other Papers

Childhood cancer survivors (CCSs) are at increased risk for chronic health issues due to late effects of cancer and its treatment. We address the impact of environmental exposures, such as air pollution, tobacco smoke, extreme weather events, and pesticides, on the health and survival of CCSs. These environmental hazards have been associated with worsening health outcomes and decreased survival among CCSs on a global scale. We also highlight that providers at a major pediatric cancer center in the United States have limited knowledge and practical skills about environmental risk factors and how to reduce exposures. Our survey results show that …

Alma Link Resolver Subject Report 2024-2025, Andrée J. Rathemacher

Technical Services Reports and Statistics

Statistics for 2024-2025 on the number of OpenURL requests by Library of Congress classification code made to the Ex Libris Alma link resolver for items held by the University of Rhode Island Libraries.

Information provided includes Classification Code, Classifications, Number of Requests, Number of Clicked Requests, and % Clicks from Requests.

Summary Of: Immersive Modeling Of Water Banking Elicits Local Knowledge And Strategies To Get More Water To Great Salt Lake, Hadia Akbar, David E. Rosenberg

Civil and Environmental Engineering Student Research

Getting more water to the declining Great Salt Lake (GSL) is difficult. Strategies must address complex water rights, competing water needs, differing stakeholder priorities, historical legacies, lack of trust, and more arid and variable hydrology. Here we used immersive online collaborative modeling to explore water banking strategies to get more water to GSL. This 2-page brief describes the immersive modeling method, a Win-Win outcome, key results, new insights collaborators took from a model session, 2 new strategies to deliver water to GSL, and 3 next steps.

Alma Link Resolver Title & Issn Report (Top 500) 2024-2025, Andrée J. Rathemacher

Technical Services Reports and Statistics

Statistics for 2024-2025 on the total number of OpenURL requests by journal title and ISSN made to the Ex Libris Alma link resolver for items held by the University of Rhode Island Libraries. Includes only the top 500 journals.

Information provided includes journal Title, ISSN, EISSN, Number of Requests, Number of Clicked Requests, % Clicks from Requests.

The Theoretical Role Of The Wind In Aerosolising Microplastics And Nanoplastics From Coastal Combined Sewer Overflows, Lauren Biermann, David Moffat, Clive E Sabel, Thomas E Stovin

School of Geography, Earth and Environmental Sciences

Inhaled microplastics and nanoplastics (MNPs) have shown bio-persistence in the body, with concerning implications for human health. Airborne MNPs primarily originate from terrestrial sources, but sea air may contribute when onshore 'aerosolising' winds coincide with high concentrations of MNPs in surface waters. From the thousands of cities worldwide with Combined Sewer Overflows, millions to billions of MNPs can be discharged daily into rivers, estuaries, and the sea. To assess the possible links between water pollution and air quality, we analysed two years of Combined Sewer Overflows (spills) off Plymouth, UK, alongside same-day and long-term meteorological and satellite data. Winds exceeding …

Impact Of Fructose-Enhanced Solid And Soft Drink Diets On Metabolism, Physiology, And Gut Microbiome In Pregnant Rats, Xiaoyuan Han, Linda D. Shortliffe, Neeraja Kambham

Pacific Faculty Work

Introduction: High fructose consumption is linked to hypertension and metabolic disorders. We hypothesize fructose (solid and/or liquid) may further influence dietary patterns. To investigate potential effects, we compared eating behaviors, physiological and metabolic measures, and gut microbiome in pregnant rats fed solid or liquid fructose-enhanced (soft drink) diets to those fed standard chow. Methods: Pregnant rats were assigned to three dietary groups: (1) standard chow and water (CW), (2) standard chow and decarbonated soft drink (CS, decarbonated Sprite with 5.89% fructose w/v), and (3) 60% fructose chow and water (FW). Body weight, blood pressure, food and liquid intake, fasting blood …

Irradiation Of Prostate Cancer Alters Circulating Small Extracellular Vesicle Functions, Aejaz Sayeed, Vaughn Garcia, Cecilia E. Verrillo, Rachel M. Derita, Md Niamat Hossain, Shiv R. Krishn, Samuel Sey, Christopher D. Shields, Adrian D. Altieri, Qin Liu, Khalid Sossey-Alaoui, William K. Kelly, Lucia R. Languino

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

It is known that β1 integrins and a downstream signaling molecule c-Src are upregulated in prostate cancer (PrCa) tissues, are co-expressed in circulating small extracellular vesicles (sEVs) and contribute to cancer progression. Here, we demonstrate that sEVs from PrCa patients show robust expression of both β1 integrins and c-Src. The impact of irradiation, a widely used therapy for the treatment of PrCa, on circulating sEVs is however not fully understood. We show that sEVs isolated from the plasma of transgenic adenocarcinoma of mouse prostate (TRAMP) mice, stimulate migration and anchorage-independent growth of recipient cancer cells, but sEVs are not active …

Detecting Ionospheric Disturbances Using High Frequency Coastal Radar Transmissions From The West Coast Of The United States, Riley N. Troyer, Kenneth Obenberger, Michael Negale, Eugene Dao, Zsolt Balint, Eric Burnside, Kris Robinson, Jeffrey M. Holmes, Pavel Inchin, Jonathan Snively

Space Dynamics Laboratory Publications

Coastal radar system are located around the world and many happen to transmit at frequencies capable of skywave propagation via the ionosphere. Therefore, they can be detected hundreds to thousands of kilometers away. This paper demonstrates the opportunity to detect 39 Coastal Ocean Dynamics Application Radar transmitters located on the western coast of the United States using three HF radio receivers in Utah and New Mexico. It also illustrates the possibility to use the phase and Doppler measurements of these signals to derive displacements of the refracting ionospheric layer up to meter resolution for the 2023 annular solar eclipse, an …

Making The New Public Safety Safe, Christopher Slobogin

Vanderbilt Law School Faculty Publications

Shawn Fields' The New Public Safety: Police Reform and the Lurking Threat to Civil Liberties, which will be published by the University of California Press in September, is a brave and wise effort to envision a post-DeFund the Police world. While the defund movement has, at best, been a mixed success, some municipalities have experimented with de-policing routine interactions with people who are unhoused and mentally ill, authorizing civilian "violence interrupters" to roam the streets, and handing over traffic enforcement to unarmed officials. In The New Public Safety, Fields endorses these developments but also cautions that, without regulation, they will …

Lived Experiences Of Sexual Orientation Discrimination Of Gay Male Service Members, Dwayne A. Tyler

Walden Dissertations and Doctoral Studies

The repeal of the Don’t Ask, Don’t Tell policy (DADT) has been an area of study among scholars since 2011. Researchers have demonstrated that discrimination based on sexual orientation is still occurring in the armed forces. However, researchers have not studied the lived experiences of active-duty male service members in the army who self-identified as gay. The purpose of this phenomenological qualitative study was to examine the lived experiences of discrimination based on the sexual orientation of male service members who self-identified as gay in the army since the repeal of the DADT policy. Using semi-structured interviews, four self-identified gay …

Lived Experiences Of Ex-Offenders In Securing Stable Employment After Reentry Programs, Tony Lemar Williams

Walden Dissertations and Doctoral Studies

The reintegration of formerly incarcerated individuals into society has garnered increasing attention largely due to structural and social barriers that impede their successful transition. The purpose of this qualitative descriptive phenomenological study was to explore the lived experiences of ex-offenders who successfully obtained gainful employment following their reintegration into society while navigating the enduring consequences of their past convictions. Self-determination, self-efficacy, and implicit theories grounded this study. Ten participants were recruited through social media platforms and flyers on community billboards in a suburban area of Ohio. Data were collected using semistructured in-depth interviews. Narrative coding, according to Saldana, was used …

Personal Social Media Usage And The Effect On Individuals’ Job Satisfaction: A Social Identity Theory Perspective, Daniel Adam Blair

Walden Dissertations and Doctoral Studies

Social networking sites are web-based platforms that serve as tools to enhance connectivity and communication for a broad spectrum of different individuals, but they may be doing a disservice to the users who overuse the platforms as a means to bolster their self-esteem surrounding their different identities. The purpose of this study was to examine the differences in individuals’ job satisfaction levels when using personal social media (PSM) to varying degrees and how individuals’ social identities may influence this interaction. Utilizing the social identity theory framework, this study aimed to determine whether a relationship exists between PSM usage and job …

Strategies In Cybersecurity For The Protection Of Patient Health Information (Phi), Denise Holloway

Walden Dissertations and Doctoral Studies

Health information technology (IT) professionals are consistently seeking better ways to balance the availability of patient health information (PHI) with data breach prevention, as these breaches negatively impact health organizations legally and ethically due to the exposure of PHI. However, some health IT professionals lack strategies to protect PHI against cybersecurity attacks. Grounded in Dr. Edward Hutchins’ distributed cognition framework, the purpose of this qualitative pragmatic inquiry was to understand what strategies health IT professionals use to protect PHI against cybersecurity attacks. The participants were six IT professionals from Washington D.C., Maryland, and Virginia with at least five to seven …

Genetic Gain And Loss In The Evolution Of Amniote T Cell Receptor And Immunoglobulin Genes, Jordan M. Sampson

Biology ETDs

The immune system of most jawed vertebrates consists of three major cell types: αβ T cells, γδ T cells, and B cells. Every species evaluated contains the loci that encode the highly conserved αβ T cells, however, γδ T cells are less conserved and have been lost in squamate reptiles. The loci that encode the B cell receptor have also varied across evolution. Seven immunoglobulin (Ig) heavy chain isotypes have been identified in amniotes: IgM, IgD, IgY, IgG, IgE, IgO, and IgA. Some are found in most species (IgM and IgD) and others only in specific lineages (IgY or IgG). …

Elementary School Administrators Perceptions Of School-Wide Restorative Practices In A School District In Georgia, Simone Simmons

Walden Dissertations and Doctoral Studies

This basic qualitative study explored the perceptions of elementary school administrators regarding the uses of restorative practices (RPs) to address an increase in undesirable behaviors among K–5 students in a northern public school district in Georgia. Guided by restorative justice theory, which emphasizes repairing harm and fostering positive relationships, the study focused on understanding how administrators perceive the effectiveness of RPs in managing student behavior during instructional time. The research questions focused on administrators’ perceptions of the effectiveness of RPs in addressing student behaviors in the classroom. Data were collected through semi-structured interviews with 10 elementary school administrators from the …

Medical Biotechnology Symposium Sultan Qaboos University, Muscat, Oman 5th And 6th February 2024 Gene Hunting In Breast Tumours And Cells To Reveal Chemotherapy Resistance As Predictive Markers Of Response, Sultan Qaboos University

Sultan Qaboos University Medical Journal

No abstract provided.

Cat: A Conditional Association Test For Microbiome Data Using A Permutation Approach, Yushu Shi, Liangliang Zhang, Kim-Anh Do, Robert R Jenq, Christine B Peterson

Faculty, Staff and Student Publications

In microbiome analysis, researchers often seek to identify taxonomic features associated with an outcome of interest. However, microbiome features are intercorrelated and linked by phylogenetic relationships, making it challenging to assess the association between an individual feature and an outcome. This paper proposes a novel conditional association test, CAT, that can account for other features and phylogenetic relatedness when testing the association between a feature and an outcome. CAT adopts a permutation approach, measuring the importance of a feature in predicting the outcome by permuting operational taxonomic unit/amplicon sequence variant counts belonging to that feature from the data and quantifying …

Is My Stress Out Of Place? Bread Wheat Response To Saline Stress Varies In Pattern And Extent Across Experimental Settings, Anne Plessis

School of Biological and Marine Sciences

Adopting crops and agricultural practices that help sustain yield under abiotic stress will be a major element of future food security under climate change. However, little of the intensive research into the mechanisms of plant abiotic stress response has translated into improved yield stability. A suspected obstacle to translatability of research findings in this area is artificial experimental conditions, but we lack evidence to support this explanation. Here, we combined a meta-analysis and an experimental approach to compare the effect of salt stress on wheat yield, growth, and physiology across four distinct experimental settings: field/field-like conditions, potted plants in a …

A Sensory Investment Syndrome Hypothesis: Personality And Predictability Are Linked To Sensory Capacity In The Hermit Crab Pagurus Bernhardus, Ari Drummond, Summer Nash, Tianna Holloway, Alexander Wilson, Lucy Turner, Mark Briffa

School of Biological and Marine Sciences

Correlated phenotypic traits (i.e., syndromes) may manifest as associations between different behavioural types or between behavioural and non-behavioural phenotypes. While syndromes research is extensive, correlations involving behavioural type and sensory morphology have yet to be investigated. Sensation is essential in decision-making and should be correlated with behavioural phenotypes involved in risk response, including boldness. We investigated correlations between boldness and sensory capacity in Pagurus bernhardus hermit crabs, taking repeat measures of startle response durations to assess hermit crab personality and predictability. The correlation between startle response and the sensillar density (i.e., number of sensilla per unit surface area) of both …

Discharge System Field Sampling Plan, 2025 Update Silver Bow Creek/Butte Area Npl Site Butte Mine Flooding Operable Unit | Butte, Montana, Mark Thompson, Dave Griffis

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Structural And Functional Characterization Of Creb-Binding Protein (Crebbp) As A Histone Propionyltransferase, Guiling Cui, Marie Ley, Ariel E Mechaly, Linh-Chi Bui, Christina Michail, Jérémy Berthelet, Julien Dairou, Haopeng Yang, Guillaume Chevreux, Gautier Moroy, Michael R Green, Ahmed Haouz, Fernando Rodrigues Lima

Faculty, Staff and Student Publications

In addition to histone acetylation, histone lysine propionylation (such as the H3K18Pr mark) has recently attracted significant attention as a common and abundant modification linking the cellular metabolic state and gene expression. CREB-binding protein (CREBBP) and EP300 are key histone acetyltransferases that play a critical role in gene expression through their catalytic activity. Although CREBBP and EP300 are homologous enzymes with high structural similarities, they exhibit both redundant and specific functions. Dissecting the shared and divergent properties of CREBBP and EP300 is thus important to understand their roles. However, despite the importance of CREBBP, most mechanistic and structural studies have …

Effects Of Meeting Exercise Guidelines On Depression And Anxiety In Multiple Sclerosis – A Systematic Review And Meta-Analysis, Sodiq Fakorede, Joseph Peters, Tanner Murphy, Ethan Truong, Libak Abou

Student Publications

Background: Depression and anxiety are common in multiple sclerosis (MS), significantly affecting quality of life. Previous studies on exercise interventions for mental health in persons with MS (PwMS) have shown mixed results, partly due to inconsistent adherence to the Physical Activity Guidelines for Multiple Sclerosis (PAG-MS).

Objective: This study aimed to evaluate the effects of PAG-MS-compliant exercise on depression and anxiety outcomes in PwMS.

Methods: A systematic search was performed in EMBASE, PsycINFO, Web of Science, SPORTDiscuss, PubMed, Scopus, and CINAHL through October 2024 to identify randomized controlled trials (RCTs). Eligible studies involved adults with MS and focused on exercise …

A Scoping Review Of Personalised Uk Maternity Care: Where Are We Now?, Louisa Tompkins, Gary Hodge, Jill Shawe, Lisa Burrows, Annick Bogaerts, Susie Pearce

School of Nursing and Midwifery

Background/AimsPersonalised care has been recommended continuously to improve UK maternity services. The aim of this review was to explore the current provision of personalised care and consider why it may not yet be fully embedded in practice.MethodsThis review of Embase, Medline, the Healthcare Management Information Consortium, the British Nursing Index, CINAHL, Google Scholar and reference lists found 15 articles published between 2014 and 2024, which were included for thematic analysis and synthesis.ResultsThe themes included the complexities of personalised care, different perspectives when implementing personalised care and the effect of cultural factors embedded in maternity services.ConclusionsBarriers to implementing personalised care include …

Innovating For Improvement — Improving Pressure Damage Prevention And Treatment In The Community Using Continuous Pressure Monitoring, Bridie Kent, Nicci Aylward-Wotton, Peter R. Worsley

School of Nursing and Midwifery

Each year, approximately half a million people in the UK develop pressure ulcers (PUs), with most occurring in the community among individuals with underlying comorbidities, frailty, mobility issues and a dependence on carers. Pressure relief is essential for healing, however, some patients find pressure-relieving equipment uncomfortable, hot and noisy, thus refusing to use it and are, therefore, often labelled as non-concordant. This service improvement project evaluated the ForeSite PT® pressure monitor to identify PU risk, support healing and influence patient and carer decision making, assessing its useability, alongside patient and carer education. The technology consisted of a mattress- and chair-sized …

Artificial Intelligence For Detecting Non-Alcoholic Steatohepatitis (Nash), Muhammad Wildan Gifari, Yogi Ramadhani, Dhadhang Wahyu Kurniawan

Pharmaceutical Sciences and Research

Non-alcoholic steatohepatitis (NASH), an inflammatory disease of the liver, has recently raised concern among healthcare professionals worldwide due to its asymptomatic features, making early diagnosis challenging. If left unnoticed, NASH often progresses to lethal diseases such as liver fibrosis or hepatocellular carcinoma. Recent developments in the field of artificial intelligence (AI) might facilitate the early diagnosis of NASH in a more efficient manner, forming a promising strategy to diagnose patients. In simple terms, AI is any machine that is capable of human-level intelligence, including visual perception, speech recognition, or decision making. A subclass of AI, which particularly deals with knowledge-based …

Pan-Cancer Copy Number Analysis Identifies Optimized Size Thresholds And Co-Occurrence Models For Individualized Risk Stratification, Minh P Nguyen, William C Chen, Kanish Mirchia, Abrar Choudhury, Naomi Zakimi, Vijay Nitturi, Tiemo J Klisch, Stephen T Magill, Calixto-Hope G Lucas, Akash J Patel, David R Raleigh

Faculty, Staff and Students Publications

Chromosome instability leading to aneuploidy and accumulation of copy number gains or losses is a hallmark of cancer. Copy number alteration (CNA) signatures are increasingly used for cancer risk stratification, but size thresholds for defining CNAs across cancers are variable and the biological and clinical implications of CNA size heterogeneity and co-occurrence are incompletely understood. Here we analyze CNA and clinical data from 691 meningiomas and 10,383 tumors from The Cancer Genome Atlas to develop cancer- and chromosome-specific size-dependent CNA and CNA co-occurrence models to predict tumor control and overall survival. Our results shed light on technical considerations for biomarker …

Differential Efficacy Of Bevacizumab And Erlotinib In Preclinical Models Of Renal Medullary Carcinoma And Fumarate Hydratase-Deficient Renal Cell Carcinoma, Niki M Zacharias, Manuel Ozambela, Menuka Karki, Rong He, Pankaj K Chauhan, Pedro I Pesquera, Andres E Hernandez Gonzalez, Oscar Ochoa, Alberto Pieretti, Huiqin Chen, Carolyn De La Cerda, Zhiyuan Yu, Abha Grover, Samantha Hicks-Peña, Natalie W Fowlkes, Lei Wang, Tapati Maity, Priya Rao, Giannicola Genovese, Nizar M Tannir, Jose A Karam, Pavlos Msaouel

Faculty, Staff and Student Publications

Renal medullary carcinoma (RMC) and fumarate hydratase (FH)-deficient renal cell carcinoma (RCC) are rare and highly aggressive cancers. Although the combination of vascular endothelial growth factor (VEGF) inhibition by bevacizumab and epidermal growth factor receptor (EGFR) inhibition by erlotinib is clinically used for both diseases, the differential effect of each component has not been investigated. Transcriptomic profiling revealed that RMC and FH-deficient tumor tissues demonstrate increased EGFR but not VEGF expression compared with adjacent normal kidney. Subsequent in vitro studies revealed that RMC and FH-deficient cell lines are sensitive to erlotinib treatment, whereas clear cell RCC cell lines are resistant. …

Protective Role Of Dietary Short-Chain Fatty Acid Propionate Against Autoimmune Responses And Pathology Of Systemic Lupus Erythematosus In Mrl-Lpr Mice, Hui Wang, Yuejin Liang, Paul J Boor, Kamil Khanipov, Yuanyi Zhang, Xiaoying Yu, Chandra Shekar R Ambati, Nagireddy Putluri, M Firoze Khan

Faculty, Staff and Students Publications

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs, including the skin and kidneys. The etiology of SLE remains unclear but involves hormonal, environmental, and genetic factors. Environmental factors, such as diet and microbiota-derived metabolites, among which short-chain fatty acids (SCFAs) are major players, can influence autoimmune disease pathogenesis.

Objectives: This study investigates the involvement of SCFAs in the pathogenesis of SLE and further investigates the effect of propionate (PA) supplementation on SLE disease outcome in MRL-lpr mice.

Methods: Cecal SCFAs from mouse models with varying degrees of SLE disease activities (C57BL/6, MRL+/+, and MRL-lpr) …

Assessment Of Functioning Using The Whodas 20 Among People With Myasthenia Gravis-Associated Disability: A Nationwide Follow-Up Study, Jia-Pei Hong, Chih-Hong Lee, Chien Tai Hong, Lung Chan, Chen-Chih Chung, Prangthip Charoenpong, Hou-Chang Chiu, Tsan-Hon Liou

Faculty, Staff and Students Publications

Background: Advancements in treatment have increased the life expectancy of patients with Myasthenia Gravis (MG), yet the understanding of functional changes in these individuals remains limited. In our study, we explored the functional abilities of individuals with MG using the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0).

Methods: This observational study analyzed data from 286 patients with MG, acquired from the Data Bank of Persons with Disabilities (TDPD) in Taiwan between July 11, 2012, and December 31, 2021. Participants were diagnosed with MG after the acute phase. The functional disability outcome was assessed using the WHODAS 2.0. Due …