Digital Commons Network^™

Collaborative Strategies In Self-Protection Against Sexual Violence For Children With Intellectual Disabilities: Systematic Literature Review, Zulfa Rahmah Effendi, Endang Rochyadi, Budi Susetyo, Oom Sitti Homdijah

Journal of ICSAR

This study explores collaborative strategies based on the Pentahelix model to enhance self-protection education against sexual violence for children with intellectual disabilities. Recognizing the heightened vulnerability of this population and the fragmented nature of existing protective mechanisms, this research adopts a Systematic Literature Review (SLR) method guided by PRISMA protocols. A total of 25 peer-reviewed, Scopus-indexed articles published between 2015 and 2024 were thematically analyzed. The findings reveal that multi-actor collaboration involving government, academia, communities, the private sector, and media plays a pivotal role in establishing responsive protection systems and educational interventions tailored to the specific needs of children with …

Building Quality Inclusive Schools Through Transformational Leadership, School Culture, And Digitalization: An Empirical Study In Public Elementary Schools In Tugu District, Semarang City, Munirotun Munirotun, Widya Kusumaningsih, Nurkolis Nurkolis

Journal of ICSAR

This study investigates the influence of transformational leadership, school culture, and digitalization on the quality of inclusive elementary schools in Tugu District, Semarang. As the foundation of national development, education requires not only knowledge transfer but also the cultivation of character and values. Despite being categorized as “Good,” most elementary schools in Tugu District have experienced a decline in learning quality, as indicated by the 2023 national assessment. Key challenges include teacher shortages, competency mismatches, excessive workloads, and limited understanding of the Merdeka Curriculum. Additional obstacles such as high administrative burdens and inadequate digital infrastructure further impede effective learning. Employing …

A Quantitative Study On The Determinants Of Collaborative Culture In Inclusive Primary Schools: The Role Of Social Competence, Work Motivation, And Organizational Climate, Angela Astrid Stelladiba Cindy Ayu, Bunyamin Bunyamin, I Made Sudana

Journal of ICSAR

This study aims to examine the influence of teachers’ social competence, work motivation, and organizational climate on collaborative culture in elementary schools within the Bawana Alit cluster, Tembalang District, Semarang City. Employing a quantitative approach with a correlational design, data were collected through questionnaires distributed to 153 teachers selected using proportional random sampling. The data were analyzed using descriptive statistics, multiple regression analysis, and hypothesis testing. The results showed that each independent variable social competence (r = 0.701), work motivation (r = 0.726), and organizational climate (r = 0.821) had a positive and significant influence on collaborative culture. Simultaneously, the …

Determining Graduate Quality Through School Principals’ Transformational Leadership, Teachers’ Professional Competence, And Work Motivation: A Quantitative Study, Ana Supriati, Titik Haryati, Sumarno Sumarno

Journal of ICSAR

This study aims to analyze the influence of school principals’ transformational leadership, teachers’ professional competence, and work motivation on the quality of graduates in public junior high schools in Rembang Regency. A quantitative approach was employed using a survey method involving 289 teachers as respondents. The research instrument used a Likert-scale questionnaire tested for validity and reliability. Data were analyzed using multiple linear regression techniques. The results revealed that both partially and simultaneously, the three independent variables had a positive and significant influence on the quality of graduates. Transformational leadership fosters a supportive school climate, professional competence enhances teaching effectiveness, …

Toward Inclusive Higher Education: Challenges And Opportunities In Ten Asian Countries Following Crpd Ratification, Mohammad Idrees Naeemy, Hiroki Yoneda

Journal of ICSAR

The ratification of the Convention on the Rights of Persons with Disabilities (CRPD) has triggered a wave of policy initiatives aimed at inclusive higher education around the world. Yet the extent of progress remains unclear in Asian region. This systematic review fills that gap by analysing 46 peer-reviewed publications (2013–2024) that document post-CRPD developments in ten Asian countries—China, India, Iran, Japan, Kazakhstan, Malaysia, Pakistan, Singapore, Turkey and the United Arab Emirates. We mapped legislative reforms, organizational responses and structural adaptations designed to accommodate students with disabilities and compared the pace and depth of change across national contexts. The review revealed …

Holistic Approach In Inclusive Education Management In Indonesia: A Systematic Review Of Strategies And Challenges Faced By Schools, Bayu Pamungkas, Angga Damayanto, Adi Suseno

Journal of ICSAR

This study aims to analyze the strategies and challenges faced by schools in implementing inclusive education management in Indonesia. The method employed is a Systematic Literature Review (SLR) conducted in accordance with the PRISMA guidelines. The results show that schools in Indonesia have implemented various strategies to support inclusive education, including curriculum adaptation, teacher professional development, collaboration with stakeholders, provision of facilities and infrastructure, utilization of technology, and holistic approaches. However, challenges such as lack of understanding and support, limited resources, and difficulties in developing adaptive curricula and inclusive learning methods still exist. This research highlights the importance of collaborative …

Digital Menstrual Health Education For Adolescent Girls With Intellectual Disabilities: Evidence From The Kesmens Digital Media Intervention, Ana Fatimatuzzahra, Endang Rochyadi, Riksma Nurhami Akhlan, Een Ratnengsih, Mughi Puspa Annisi

Journal of ICSAR

Adolescent female with intellectual disabilities often encounter substantial barriers in managing menstrual hygiene, which may negatively impact their physical health, social integration, and personal autonomy. These challenges are largely attributed to the absence of concrete and developmentally appropriate educational tools, along with limited support from families and educators during menstruation. This study evaluates the effectiveness of the KESMENS Digital Book, a family assisted multimedia learning resource, in improving menstrual hygiene management skills among adolescents with intellectual disabilities. Using a Single Subject Research method with an A B design, the intervention was implemented for a junior high school student at SLBN …

Deep Learning For Personalized Learning: Tailoring Curriculum To Student Needs, Muh. Fihris Khalik, Ardi Azhar Nampira

Journal of ICSAR

The technological transformation of the digital era has significantly reshaped the educational landscape, driving a shift toward more personalized learning approaches. This study explores the integration of deep learning technologies in tailoring curriculum to meet the individual needs of students. Using a qualitative literature review, it examines how deep learning can identify learning behavior patterns, assess students' strengths and weaknesses, and deliver timely and relevant instructional interventions. The findings suggest that personalized learning powered by artificial intelligence (AI) and adaptive curricula can enhance student motivation, learning effectiveness, and inclusivity. However, the implementation also poses challenges, including concerns over data privacy, …

Assessing Significance Of Inclusive Education As A Remedy Of Addressing The Challenges Of Disabled Children, Sive Makeleni, Onyinyechi Glory Ndu

Journal of ICSAR

The issue of disability in the lives of many children has raised a lot of debates by scholars in terms of their learning ability and meeting immediate needs. This study focuses on the inclusive education for dealing with special needs of children. It aimed at assessing the significance of inclusive education and training as a remedy for addressing the challenges facing the disabled children in dealing with their special needs. What their immediate needs are, and finally suggest measures to put in place in addressing the identified problems. The study employed a literature review method. The data was collected using …

Direct Inhibition Of Ras Reveals The Features Of Oncogenic Signaling Driven By Ras G12 And Q61 Mutations, Michelangelo Marasco, Dinesh Kumar, Santiago Garcia Borrego, Tessa Seale, Giulia Maddalena, Riccardo Mezzadra, Kylie Belanger, Soren Cole, Brayan Perez, Wei Luan, Radha Mukherjee, Ilinca Aricescu, Vladimir Markov, Yuxin Zhu, Sabrina Arena, Alberto Bardelli, Elisa De Stanchina, Scott W Lowe, Richard A Burkhart, Jacquelyn W Zimmerman, Rona Yaeger, Scott E Kopetz, Neal Rosen, Sandra Misale

Faculty, Staff and Student Publications

RAS genes are frequently mutated in cancer, often at codons 12 and 61. With the recent introduction of RAS inhibitors, we can now directly investigate the effects of specific RAS mutations in cancer cells. In this study, we demonstrate that in tumors with RASG12X mutations, mutant RAS can be activated by receptor tyrosine kinases (RTK), and PI3K activation is dependent on mutant RAS. Conversely, RASQ61X mutations activate the MAPK cascade independently of RTKs, and inhibition of RASQ61X impairs MAPK pathway activation but leaves the PI3K pathway unaffected. Our characterization of these distinct features of G12X and Q61X mutations suggests that …

Ptpn11 Mutations Define A Rare But Highly Adverse Subset Of Myelodysplastic Syndromes, Alexandre Bazinet, Alex Bataller, Guillermo Montalban-Bravo, Kelly Chien, Koji Sasaki, Wei Ying Jen, Mahesh Swaminathan, Tapan Kadia, Courtney Dinardo, Farhad Ravandi, Guillermo Garcia-Manero, Hagop Kantarjian

Faculty, Staff and Student Publications

No abstract provided.

Optimization Of Participation Path Of Trade Union Organizations In Social Co-Governance Of Food Safety, Xu Chaofan

Food and Machinery

In the context of China's social co -governance of food safety,advancing the participation of trade union organizations plays a significant role in enhancing workers' professional quality through education and training,and strengthening corporate responsibility through collective bargaining.Although notable progress has been made in current practices,challenges still exist,including the relatively simple form of popular science education,the insufficient effectiveness of new media publicity,and the inadequate support for workers' food safety reporting by trade union organizations.To address these challenges,solutions should be explored from multiple perspectives:diversifying public science education methods,forming a full -media publicity strategy for trade unions in food safety co -governance,and improving support …

Preparation And Structural Analysis Of Antioxidant Peptides From Tilapia Skin By Microwave-Assisted Enzymatic Hydrolysis, Mi Chunxiao, Zhou Hui, Hu Xingyuan, Zhu Wanting, Wu Long

Food and Machinery

［Objective］ To prepare antioxidant peptides from tilapia skin by microwave -assisted enzymatic hydrolysis and conduct structural analysis.［Methods］ The processing conditions for preparing antioxidant peptides by microwave pretreatment -assisted alkaline protease hydrolysis are optimized through single -factor and response surface experiments,and the effects of microwave treatment on the structure of fish skin,the relative molecular weight,amino acid composition,and antioxidant activity of antioxidant peptides are analyzed.［Results］］ The optimal processing conditions for preparing antioxidant peptides by microwave -assisted enzymatic hydrolysis are as follows:microwave power of 441.50 W,microwave temperature of 61.00 ℃,microwave time of 20 min,hydrolysis time of 6.21 h,enzyme dosage of 2.20%,and solid -to-liquid …

The Relevance Of Climate Change And Sustainability In Nursing Education: A Cross-Sectional Study Of Students’ Perspectives, Jennie Aronsson, Marie Elf, Paul Warwick, Riccardo Lomartire, Anna Anåker

School of Nursing and Midwifery

Background: As climate change continues to challenge global health, nursing education must evolve to prepare future nurses for the impacts on care delivery and promote sustainable practices within the healthcare system which is itself a contributor to the climate crisis through emissions and waste. In this study we aimed to i) explore undergraduate nursing students’ attitudes towards and awareness of climate change and sustainability issues and its inclusion in nursing education at a Swedish university, and ii) explore differences in awareness and attitudes across student groups in different semesters. Methods: In this cross-sectional descriptive research study, nursing students from six …

External Challenges For Individuals Who Need Or Use Aac Who Are Learning Language: Lived Experiences, Key Research Findings, And Future Directions, Christine Holyfield, Janice Light, Dana Nieder, Jamie Preece

Communication Disorders and Occupational Therapy Faculty Publications and Presentations

Language skills are essential to effective communication, but learning language is by no means a simple process for individuals with developmental disabilities who cannot rely on speech alone to be heard and understood. Research demonstrates that augmentative and alternative communication (AAC) interventions positively impact development across language domains (e.g., pragmatics, semantics, morphosyntax) and may also benefit speech production. However, these gains can only be realized if people have timely access to effective AAC and have meaningful opportunities to interact with others. This paper integrates the lived experiences of individuals who need or use AAC and their families with key research …

Beautifying Our Home On The Plains, July 03, 2025, Tisa Mason Ed.D.

Heart of a Tiger Columns

No abstract provided.

The Use Of Burt’S Method In Rationalizing The Cost Of Time And Evaluating The Performance Companies: An Applied Study In State Company For Textile And Leather Industries - Hilla Textile Factory, Aqeel Jaber Kadhim

Muthanna Journal of Administrative and Economics Sciences

Burt’s method is a significant process research method that provides information that directly affects the scheduling process of complex projects and planning and monitoring their completion. As a result, it has gained notoriety among practitioners in the field of specialization and offers additional advantages through computer systems for completion. It seeks to finish the project as quickly as possible while using the resources and capabilities that are available and at the lowest feasible cost. The evaluation of the performance of companies is represented in the extent of the ability of the company’s management to evaluate the performance of its activities …

A Case Study In Evolving Academic Governance: Democratic Accountability And Academic Capitalism, William C. Schulz, Denise Dezolt

Higher Learning Research Communications

As the higher education market becomes both more competitive and fragmented (as well as controlled through uncertain and changing regulatory regimes), and as those whom the higher education market serves become more discerning as consumers who apply proven customer behaviors within the market, universities must re-evaluate their internal governance systems. Re-evaluation of customer behaviors and governance systems may allow universities to become more inclusive, responsive, and adaptive within an academic capitalism setting.

In this case study, we present a research-based and integrated “Shared, Informed, Stakeholder-Engaged Governance” model. We describe how a large online university developed and implemented a model that …

Squash Bug Integrated Pest Management, Nick Volesky, Marion Murray

All Current Publications

This infographic reviews integrated pest management for squash bugs. It includes information on the following: resistant varieties of vegetables to plant and crop rotation, homemade traps, mechanical destruction, mulches, trap crops, natural enemies, and organic and synthetic insecticides.

A Comparison Of Different Posterior Arthrodesis Techniques Versus Anterior Dens Screw For Odontoid Fractures: A Systematic Review And Meta-Analysis, Pavlos Texakalidis, Stavros Matsoukas, Michael Cloney, Mykhaylo Krushelnytskyy, Kevin Swong, Najib El Tecle, Tyler Koski, Nader Dahdaleh

Department of Neurosurgery Faculty Papers

BACKGROUND AND OBJECTIVES: Odontoid fractures are often managed surgically. The most common approaches are anterior dens screw (ADS) and posterior arthrodesis (PA), with the latter being associated with significantly higher fusion rates. PA techniques can include wiring, C1-C2 transarticular (TA) screws, and C1 lateral mass (LM)-C2 pars/pedicle screws. Most comparative studies group multiple PA techniques together when comparing PA versus ADS. Our objective was to systematically review the literature and identify studies that separately provide fusion rates of each different posterior C1-C2 arthrodesis (PA) technique utilized compared to ADS.

METHODS: A systematic literature review was conducted according to the Preferred …

Factors Related To Hypertension In Pediatric Patients Who Do Not Have Obstructive Sleep Apnea: A Retrospective Chart Study, Alyssa Exarchakis, Alexandra Cohen, Penghao Wang, Seema Rani, Diana Martinez

Department of Medicine Faculty Papers

Background/Objectives: The relationship between OSA and adult hypertension has been extensively studied; however, it remains understudied in pediatric patients without OSA. The aim of this study is to identify factors associated with pediatric hypertension without OSA, through an IRB-approved retrospective chart review of patients who underwent polysomnography at Nemours Children's Hospital, DE/NJ between January 2020 and July 2023. Methods: Eligibility criteria included children 8-17 years, completed PSG, and clinic visit blood pressure (BP). Anthropometrics, demographics, social determinants, and medical history were obtained from electronic medical records. Hypertension was defined as the average systolic and/or diastolic BP that is …

Amino Acid Transporter Lat1 (Slc7a5) Promotes Metabolic Rewiring In Tnbc Progression Through The L-Trp/Qprt/Nad+ Pathway, Margot Y. Fedoroff, Lei Zhao, Shaomin Wang, Alok Bhushan, Haifeng Yang, Karen M. Bussard, Stephen C. Peiper, Jun He

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Cancer cells uptake excessive nutrients by expressing higher levels of glucose and/or amino acid transporters to meet their increased energy demands. L-type amino acid transporter 1 (LAT1), is regarded as a cancer-specific transporter for the uptake of large neutral amino acids such as L-tryptophan. However, the mechanism by which LAT1 rewires cellular metabolism to promote cancer progression and chemoresistance have not yet been investigated.

METHODS: The protein levels of LAT1, p-PKM2, and p-LDHA were determined in breast cancer tissue arrays by immunohistochemistry staining followed by survival analysis. The orthotopic breast cancer models in mice, syngeneic breast cancer models, and …

Restoring P53 Wild-Type Conformation In Tp53-Y220c-Mutant Acute Myeloid Leukemia, Bing Z Carter, Po Yee Mak, Edward Ayoub, Xiaogang Wu, Baozhen Ke, Yuki Nishida, Andrew Futreal, Lauren B Ostermann, Andrea D Bedoy, Steffen Boettcher, Courtney D Dinardo, Anna Puzio-Kuter, Masha V Poyurovsky, Arnold J Levine, Michael Andreeff

Faculty, Staff and Student Publications

TP53-Y220C is a recurrent hotspot mutation in cancers and leukemias. It is observed predominantly in acute myeloid leukemia (AML)/myelodysplastic syndromes among hematological malignancies and is associated with poor outcome. The mutation creates a structural pocket in the p53 protein. PC14586 (rezatapopt) is a small molecule designed to bind to this pocket and thus restore a p53-wild type (p53-WT) conformation. We demonstrate that PC14586 converts p53-Y220C into a p53-WT conformation and activates p53 transcriptional targets, but surprisingly induces limited/no apoptosis in TP53-Y220C AML. Mechanistically, MDM2 induced by PC14586-activated conformational p53-WT and the nuclear exporter XPO1 reduce the transcriptional activities of p53, …

Building Belonging Infrastructure In Cities: Arts/Culture-Based Critical Participatory Action Research And Youth, Kimberly Rae Nightingale

Dissertations and Theses

Belonging is a critical human need. Urban planning's history of bureaucratic expertise continues to champion the powerful, resulting in structures and procedures that still separate and damage city communities. This research challenges the current hegemony of urban planning that centers geography--the container of land--in its practice. Instead, centering the belonging of people to each other is the essential quality of healthy urban planning. A people-centered urban planning practice where the community's people are the experts and decision-makers of their own cities--and belonging is the primary objective--is long overdue.

Arts/culture-based critical participatory action research (PAR)--where the research questions, design, data collection, …

Genome-Wide Association Study For Lung Cancer In 6531 African Americans Reveals New Susceptibility Loci, Jinyoung Byun, Younghun Han, Jiyeon Choi, Ryan Sun, Vikram R Shaw, Catherine Zhu, Xiangjun Xiao, Christine Lusk, Hoda Badr, Hyun-Sung Lee, Hee-Jin Jang, Yafang Li, Hyeyeun Lim, Erping Long, Yanhong Liu, Linda Kachuri, Kyle M Walsh, John K Wiencke, Demetrius Albanes, Stephen Lam, Adonina Tardon, Marian L Neuhouser, Matt J Barnett, Chu Chen, Stig Bojesen, Hermann Brenner, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeböller, David C Christiani, Gad Rennert, Susanne Arnold, John K Field, Sanjay Shete, Loic Le Marchand, Geoffrey Liu, Angeline S Andrew, Shanbeh Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Fiona Taylor, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Alpa Patel, Xihong Lin, Krista A Zanetti, Curtis C Harris, Stephen Chanock, James Mckay, Ann G Schwartz, Rayjean J Hung, Christopher I Amos

Faculty, Staff and Student Publications

Despite lung cancer affecting all races and ethnicities, disparities are observed in incidence and mortality rates among different ethnic groups in the United States. Non-Hispanic African Americans had a high incidence rate of lung cancer at 55.8 per 100 000 people, as well as the highest death rate at 37.2 per 100 000 people from 2016 to 2020. While previous genome-wide association studies (GWAS) have identified over 45 susceptibility risk loci that influence lung cancer development, few GWAS have investigated the etiology of lung cancer in African Americans. To address this gap in knowledge, we conducted GWAS of lung cancer …

Our Ethical Duty: Assessing The Competencies Of Counselors-In-Training For Counseling With Transgender And Gender Expansive Clients, Deanna N. Cor, M. N. Saltis, Megan Doughty Shaine, Lauren Streeter

Counselor Education Faculty Publications and Presentations

Counselors report a lack of competence in working with transgender and gender expansive (TGE) individuals. TGE people report a lack of competent and affirming care. This study used the Gender Identity Counselor Competency Scale- Revised (GICCS-R) to understand self-reported competence and training levels in working with this population. Participants were 90 masters-level counselors in training who had at least started practicum in CACREP-accredited programs. Hierarchical linear regression was utilized to determine factors that predict competence including identities and training levels. Results highlight a lack of perceived competence in skill-based training. Counselor education programs must focus on improving TGE affirmative skills.

Testosterone Deficiency And Treatments: Common Misconceptions And Practical Guidance For Patient Care, Mohit Khera, James M Hotaling, Martin Miner

Faculty, Staff and Students Publications

Introduction: Misconceptions about testosterone therapy are prevalent and there is an unmet need for a review of current literature that can be leveraged by physicians to deliver safe and effective care for men with hypogonadism.

Objectives: This review aims to address common misconceptions about testosterone therapy using current literature and synthesize practical guidance for clinicians with patients who are starting testosterone therapy.

Methods: A literature search of PubMed, Embase, CINAHL was carried out to identify associations between testosterone therapy and prostate cancer, cardiovascular risk, and hepatic toxicity; definitions of hypogonadism; and practical guidance for clinician with patients starting testosterone therapy. …

Atrial Fibrillation Or Flutter In Patients Undergoing Stem Cell Transplantation, In-Hospital And Post-Discharge Outcomes In A Large Nationwide Sample Across The United States, Raja Zaghlol, Elena Deych, Nina Manian, Ahmed Altibi, Joshua D Mitchell

2020-Current year OA Pubs

BACKGROUND: Stem Cell Transplantation (SCT) is a cornerstone therapy in managing several malignant and benign hematological conditions. Atrial fibrillation/atrial flutter (AF) are commonly encountered in patients receiving SCT. There is a paucity of large-scale data on the prevalence of AF and their effect on outcomes following SCT.

METHODS: The United States National Readmission Database (NRD) was used to identify hospitalized patients who underwent SCT. Baseline demographics, comorbidities, the presence or absence of AF, the indication, and type of SCT were identified using diagnostic and procedural International Classification of Diseases 10th Edition (ICD-10) codes. Patients with AF were compared to those …

Hallmarks Of Stem Cell Aging, Thomas A Rando, Anne Brunet, Margaret A Goodell

Faculty, Staff and Students Publications

As organisms age, somatic stem cells progressively lose their ability to sustain tissue homeostasis and support regeneration. Although stem cells are relatively shielded from some cellular aging mechanisms compared with their differentiated progeny, they remain vulnerable to both intrinsic and extrinsic stressors. In this review, we delineate five cardinal features that characterize aged stem cells and examine how these alterations underlie functional decline across well-studied stem cell compartments. These hallmarks not only provide insight into the aging process but also serve as promising targets for therapeutic strategies aimed at rejuvenating stem cell function and extending tissue health span.

Characteristics Of Hospitals Participating In The Transforming Episode Accountability Model, Sukruth A Shashikumar, Jie Zheng, Thomas C Tsai, E John Orav, Arnold M Epstein, Karen E Joynt Maddox

2020-Current year OA Pubs

No abstract provided.