Digital Commons Network^™

Sensing The Stiffness: Cellular Mechano-Sensing At The Implant Interface, Patricia S Pardo, Delia Danila, Raja Devesh Kumar Misra, Aladin M Boriek

Faculty, Staff and Students Publications

In this perspective, we highlight the relevance of the FA-Hippo signaling pathway and its regulation of the Yes-associated protein (YAP) and the transcriptional coactivator with a PDZ-binding domain (TAZ) as main players in the process of implants integration. The modulation and responses of YAP/TAZ triggered by substrate and ECM stiffness are of particular interest in the construction of materials used for medical implants. YAP/TAZ nuclear localization and activity respond to the substrate stiffness by several mechanisms that involve the canonical and non-canonical Hippo signaling and independently of the Hippo cascade. YAP/TAZ regulate the expression of genes involved in several mechanisms …

Stimulated Cytokine Production, Attachment, And Emotional Well-Being In Dementia Spousal Caregivers, Daniel L. Argueta, Sarah Roberts, Kelly N. Brice, E Lydia Wu-Chung, Vincent D. Lai, Jensine Paoletti-Hatcher, Bryan T. Denny, Charles Green, Samantha Henry, Multiple Additional Authors

Psychology Faculty Publications and Presentations

Proinflammatory cytokine production may be related to poor emotional adjustment in dementia spousal caregivers. People who display attachment insecurity may be at increased risk for adverse caregiving experiences and poor psychosocial outcomes.

Development And Validation Of Risk Models For Hospital-Acquired Bleeding In Medical Inpatients: The Medical Inpatients Thrombosis And Hemostasis (Mith) Study, Neil A Zakai, Katherine Wilkinson, Andrew D Sparks, Ryan T Packer, Nicholas S Roetker, Allen B Repp, Mansour Gergi, Chris Holmes, Mary Cushman, Timothy B Plante, Hanny Al-Samkari, Allyson M Pishko, William A Wood, Camila Masias, Radhika Gangaraju, Ang Li, David Garcia, Kerri L Wiggins, Jordan K Schaefer, Nicholas L Smith, Augusto Ferraris, Karlyn A Martin, Deirdra R Terrell, Leslie A Mcclure

Faculty, Staff and Students Publications

Background: Hospital-acquired (HA) bleeding in medical inpatients is a serious complication with limited tools to predict risk.

Objectives: This study aimed to develop and validate risk assessment models (RAMs) for anatomic location-specific HA bleeding in medical inpatients using objective and routinely available risk factors.

Methods: Patients aged ≥18 years admitted to medical hospital services from 6 health systems and 15 hospitals in the United States between 2016 and 2020 for at least 1 midnight and without bleeding at admission were eligible for inclusion. Two health systems (10 hospitals) formed the development cohort, and 4 systems (5 hospitals) constituted the validation …

Prognostic Gene Expression And Microrna Profiling Signatures And Genetic Alterations In Primary Testicular Diffuse Large B-Cell Lymphoma, Wenyu Shi, Zijun Y Xu-Monette, Youchao Jia, Alexandar Tzankov, Heounjeong Go, Ling Li, Maurilio Ponzoni, Yafei Wang, Qiongli Zhai, Anamarija M Perry, Shi Wang, Xiaoxiao Wang, April Chiu, Mina L Xu, Carlo Visco, Karen Dybkaer, Henry Withers, Mark Long, Alyssa F Yuan, Yi Miao, Everardo Macias, Dehong Wu, Wen Shuai, Bangchen Wang, Jianyong Li, Govind Bhagat, Youli Zu, Zenggang Pan, William Choi, Santiago Montes-Moreno, Weina Chen, J Han Van Krieken, Michael B Møller, Xinfang Yu, Benjamin M Parsons, Shanxiang Zhang, Eric D Hsi, Aliyah R Sohani, Jeremy S Abramson, Andrés J M Ferreri, Bing Xu, Yong Li, Ken H Young

Faculty, Staff and Students Publications

Primary testicular (PT) diffuse large B-cell lymphoma (DLBCL) is a rare and aggressive lymphoma with distinct clinical and molecular characteristics. To identify prognostic biomarkers in PT-DLBCL, in this study we analyzed DNA and RNA samples of PT-DLBCL tumors from 206 patients using next-generation sequencing platforms and assays. Genetic alteration analysis found that multiple chromosomal copy number variations (CNVs), TP53 transcript mutations with high variant allele frequency, and MCD subtype had significantly adverse prognostic effects, whereas elevated microsatellite instability had a significantly favorable prognostic effect in PT-DLBCL. Targeted RNA-seq analysis identified a PTL gene expression signature by comparing PT-DLBCL with systemic …

Microbial Nanocellulose Based Biocomposites For Soft Bone Regeneration: From Present To The Future: From The Present To The Future, Probal Basu, Nabanita Saha, Tomáš Sáha, Petr Sáha

Research Outputs: 2025-Present

Microbial nanocellulose (MC) draws special attention from the research community due to its unique nano-bio fabrication. This nanofiber-constructed biomaterial is biosynthesized by certain microbes in the purest form (devoid of lignin, pectin, and hemicellulose). Due to its striking similarities to animal collagen fibers, MC nanofibers have been used to develop osteoconductive biomaterial for soft tissue regeneration. High surface area, notable rheological properties, and biocompatibility make this material attractive for tissue regeneration. Concurrently, their bio-friendly characteristics are due to various bio-ceramic materials like calcium phosphate (CP) employed in conjunction with MC (for the development of scaffold/bio-composite). The significant interaction between MC's …

Electrophysiological Characterization Of Sex-Dependent Hypnosis By An Endogenous Neuroactive Steroid Epipregnanolone, Tamara Timic Stamenic, Ian Coulter, Douglas F Covey, Slobodan M Todorovic

2020-Current year OA Pubs

Neuroactive steroids (NAS) have long been recognized for their hypnotic and anesthetic properties in both clinical and preclinical settings. While sex differences in NAS sensitivity are acknowledged, the underlying mechanisms remain poorly understood. Here, we examined sex-specific responses to an endogenous NAS epipregnanolone (EpiP) in wild-type mice using behavioral assessment of hypnosis (loss of righting reflex, LORR) and in vivo electrophysiological recordings. Specifically, local field potentials (LFPs) were recorded from the central medial thalamus (CMT) and electroencephalogram (EEG) signals were recorded from the barrel cortex. We found that EpiP-induced LORR exhibited clear sex differences, with females showing increased sensitivity. Spectral …

Synthesis Of Cancrinite Zeolite From Toraja Natural Bentonite For Heavy Metal Removal From Wastewater, Yuli Astuti, Paulina Taba, Siti Fauziah, Syarifuddin Liong, Yusafir Hala, Nur Umriani Permatasari, Satria Putra Jaya Negara, Fadliah Fadliah

Karbala International Journal of Modern Science

This study explores the production of cancrinite (CAN) zeolite from bentonite found in Toraja (a place in South Sulawesi Province, Indonesia) and its effectiveness in removing Pb²⁺ and Fe³⁺ ions from wastewater. The synthesis was carried out using a hydrothermal method with varying NaOH concentrations, where a single phase of zeolite was formed at 5 M, as confirmed through XRD analysis. FTIR results showed the characteristics of CAN zeolite with typical absorption peaks at 676, 622, and 565 cm^-1, as well as the presence of carbonate groups (CO₃^2-) at 1300-1400 cm^-1. SEM …

Machine Learning Crime Prediction Models And The Gap Between Research And Implementation: A Systematic Review, Ricardo Huamantingo, Miguel Cano-Lengua, Ciro Rodriguez

Karbala International Journal of Modern Science

A crime is an illegal or violent act committed by one individual against another. The increasing crime rate has become a major concern as it negatively affects people's quality of life and generates significant social and economic costs. This study aims to identify the most widely used machine learning (ML) models for crime prediction, determine evaluation metrics for assessing model performance, and analyze key data characteristics to enhance real-world implementation. The study follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology. A search string was formulated using the population, intervention, comparison, and outcomes (PICO) framework and applied …

Public Safety In Smart Cities: An Experimental Study To Monitor And Record Vehicles’ Movements, Ali A. Albar, Mirza A. Baig

Yanbu Journal of Engineering and Science

This research addresses the critical issue of enhancing public safety in smart cities, with a particular focus on industrial cities in Saudi Arabia. Despite the advanced infrastructure and high safety standards in industrial cities, there are safety challenges, particularly the vulnerability of residential properties to burglaries during holidays and extended breaks. To mitigate these risks, the research proposes leveraging existing infrastructure to implement surveillance systems that monitor vehicle movements using RFID technology and smart sensors, thereby enhancing safety, supporting law enforcement in crime detection, and protecting local communities. The study also acknowledges the reduced social interaction often associated with the …

Aku-Eb Student Awards

University anniversary celebration materials

No abstract provided.

Modelling Of The Overcontact Eclipsing Binary V826 Aur, Kalev T. Murray-Rouse, John M. Cannon, Anna Williams, Wes Tobin

Macalester Journal of Physics and Astronomy

We present a model of the eclipsing binary system V826 Aur using differential photometric data from the Robert L. Mutel Telescope (RLMT) at the Winer Observatory in Sonoita, Arizona. The calculated time of superconjunction was found to be 60648.7658534 and the period was 0.361701 d. These values were used to generate a best-fit model of the eclipsing binary with the PHOEBE program. The best-fit modelled parameters were found to be: mass ratio (𝑞) is equal to 2.769, the inclination (𝑖) is equal to 80.45◦, the fillout factor (𝑓) equals 0.0961, and the temperature ratio (𝑇2∕𝑇1) is 0.9740. Although not statistically …

The Bond Of Peace: Restoring Souls In Worship Amid Culture War And Moral Suffering, Steve Yeagley

Andrews University Seminary Studies (AUSS)

Jeremiah’s critique of war as false worship challenges popular Christianity’s support of American war culture. While primarily expressed as American militarism, war culture also manifests in the rhetoric of culture wars. Adding to the division and violence that the nation’s culture wars can fuel is their potential to inflict moral suffering. Emerging discourses of moral distress and injury suggest that, like wartime environments, culture wars may exact a spiritual toll. Unlike the militant liturgies of war culture, Christian worship can address this moral suffering. When acknowledged in worship through witness and lamentation, moral distress and injury offer a prophetic critique, …

The Clarity And Obscurity Of Inspired Writings: A Historical Survey From Late Antiquity To Early Nineteenth- Century America, Denis Kaiser

Andrews University Seminary Studies (AUSS)

Throughout Christian history, pastors, scholars, and church leaders have discussed whether, or to what extent, Scripture is clear or obscure. This article surveys the views on the clarity and obscurity of Scripture as advocated by Christian writers in five eras from late antiquity to early nineteenth-century America. Writers in the Protestant tradition have generally objected to the common notions among Roman Catholics that Scripture is obscure, consists of a four-fold sense, and that normative teaching authority is in the hands of the magisterium. Lutheran, Reformed, and Pietist scholars have generally emphasized the importance of having an educated clergy that understands …

The Literary Unity Of Luke-Acts And Authorial Intent In Acts, Boubakar Sanou

Andrews University Seminary Studies (AUSS)

While some scholars have suggested that any investigation of the Gospel of Luke and Acts must include the question of their literary unity, others have focused on the purpose for which Acts was written. Since authorial intent should greatly inform the interpretation of a written work, the quest for the authorial and literary unity of Luke and Acts is inseparable from the quest for the author’s intent in writing Acts. This article argues that while the various proposals for the purpose of Acts should be considered as complementary rather than mutually exclusive, Acts 1:8 clearly appears as the interpretative key …

Tantalizing Fragments Of A Larger Linguistic Tapestry: Exploring Nala Lambë, Mago/Magol, And The Dunlendish Languages In Tolkien's World-Building, Andrew Higgins

Journal of Tolkien Research

In this paper I pluck three leaves from my current research on Tolkien’s Tree of Middle-earth language invention - – Nala Lambë, Mago/Magol, and Dunlendish (also known as the Dunland Tongue). These lesser-known languages, despite their incomplete nature or "orphaned" status, underscore Tolkien's unwavering commitment to linguistic realism and the integral role of language in his sub-creation and world-building. They exist as both individual enigmatic leafs as well part of much larger tree of Tolkien’s linguistic world-building.

Exploring Coaching Leadership Behaviours In Strength And Conditioning Coaching: Preferences Of Ncaa Division I And Ii Collegiate Student-Athletes Based On Task Variability, Severiano Tiberi, Jeremy Moody, Steve Cooper, George Jennings, Joseph I. Esformes

Journal of Athlete Development and Experience

This study aimed to explore collegiate student-athletesˈ preferences of coaching leadership behaviours in strength and conditioning coaching and evaluate differences between the student-athletesˈ preferences of behaviours based on task variability. In total 145 National Collegiate Athletic Association student-athletes (closed sports athletes = 51, open sports athletes = 94) completed an electronic questionnaire involving the athletesˈ preference version of the Revised Leadership Scale for Strength and Conditioning. Results revealed that the most favoured behaviour was ˈtraining and instructionˈ, whilst the least favoured was ˈautocraticˈ. Similar results were observed for closed and open sports groups, though closed sports athletes preferred ˈtraining and …

Need Frustration And Poor Mental Health Among Collegiate Athletes: The Indirect Role Of Ruminative Thinking, Alanni N. Brown, Adrian J. Bravo, Stimulant Norms And Prevalence 2 (Snap2) Study Team

Journal of Athlete Development and Experience

Vulnerability to negative mental health outcomes (i.e. anxiety and depression) among DI collegiate athletes may best be understood using Self Determination Theory (SDT) and the framework that need frustration impairs autonomy, competence, and relatedness. Need frustration may also relate to negative mental health symptoms via higher ruminative thinking, known to relate to both need frustration and poor mental health. The present study tested these two path models (i.e., SDT need frustration components [autonomy, relatedness, competency]-->rumination facets [problem-focused thoughts, counterfactual thinking, repetitive thinking, anticipatory thoughts]-->mental health problems (one for depression and one for anxiety as outcomes) among 341 collegiate …

Mentoring Of Para-Athletes And Its Impact On The Preparation Process For The 2020 Paralympic Games, Irina Perfilova, Joshua R. Pate, Robin Hardin

Journal of Athlete Development and Experience

Many factors contribute to successful athletic performance, and athletes have reported that mentors have played a vital role in their athletic performance as well as their personal development. Mentoring relationships can have a transformative impact on people’s lives, and mentored athletes, either by peers or coaches, have higher levels of dedication, confidence, and individual performance. Having a mentor is critically important during unexpected challenges in life such as was the case with the extraordinary uncertainty for para-athletes during the postponement of the 2020 Paralympic Games. The purpose of this study was to explore how mentoring aided para-athletes’ navigating the challenges …

Development And Transition In Crisis: The Impact Of The Covid-19 Pandemic On Division I College Athletes, Grace Kazmierski-Davie, Khalid Ballouli

Journal of Athlete Development and Experience

The aim of this study is to explore how Division I college athletes made meaning of their experiences during the onset of the COVID-19 pandemic in spring 2020. Though existing literature details various athlete transitions, there is limited knowledge about how athletes navigate unprecedented disruptions like a global pandemic. This qualitative study employed semi-structured interviews to gather in-depth data. The study included a diverse sample of 19 college athletes, ranging from freshmen to seniors, representing various sports and academic levels. Findings revealed that athletes employed diverse strategies to maintain readiness and mental sharpness, reflecting both proactive and reactive coping mechanisms. …

Secure Coding Practices: An Auditor's Checklist For Enterprise Applications For Faang By Ramkumar Bharathan, Ramkumar Bharathan

Defensive Publications Series

This report serves as a comprehensive guide to critical secure coding practices, presented as an actionable checklist for developers and security teams operating within large-scale enterprise environments. It reflects the rigorous security standards and pragmatic approaches typically observed within leading technology organizations. The core objective is to foster a "shift-left" security paradigm, integrating robust security measures throughout the Software Development Lifecycle (SDLC) to proactively identify and mitigate risks rather than reacting to vulnerabilities post-deployment. The checklist systematically addresses key areas, including input validation, authentication, access control, cryptographic practices, error handling, logging, secure file management, and system configuration. For each practice, …

Re-Assessment Of The Urban History Of Azerbaijan From Ancient Times To The Present In The Context Of General Turkic Culture, Telman Nusretoglu Quliyev, Nurlan Pashaoglu Nasirov

Khazar Journal of Humanities and Social Sciences

While the Turks have often been depicted as a nomadic people in Western and former Soviet historiographies, recent archaeological evidence and research reveals that they were instrumental in the development of settled urban civilizations, particularly during ancient and medieval times. This is particularly evident in Azerbaijan, a region historically inhabited by Turks, where they significantly contributed to the establishment of urban centers. These cities, along with their infrastructure and architectural features, have been well-documented in Greco-Roman, Arabic, Persian, and other primary sources from the period. Azerbaijan, located at the crossroads of East-West trade routes, has a long history of urbanization, …

The State And Erosion Of The Civic Space In Nigeria’S Democracy, 1999–2023, Al Chukwuma Okoli, Elias Chukwuemeka Ngwu, Francisca Nkemdilim Onah

Khazar Journal of Humanities and Social Sciences

Nigeria’s experience with democratic rule since 1999 has been somewhat contradictory. Rather than a widening of the civic space for robust citizen participation, there have been sustained attempts by the state to suffocate the civic space by stifling differing viewpoints. The government has led the process by securitizing the civic space, criminalizing civil dissent, and politicizing civil society platforms. Although there appears to have been a global trend towards the shrinking of the civic space, the situation in Nigeria has been typically enervating for fostering the democratic culture. Sequel to this, this paper examined the state of the civic space …

The Development And Psychometric Properties Of Climate Change Awareness Scale Among Higher Education Students, Şuay Nilhan Açikalin, Şefika Şule Erçeti̇n, Nihan Potas, Mehmet Sabir Çevik

Khazar Journal of Humanities and Social Sciences

Higher education has a pragmatic and educational approach to mitigating climate change and solving environmental challenges by enhancing awareness. Therefore, the study aims to develop a scale in a survey model to measure higher education students' awareness of climate change. The study group comprises higher education students enrolled at Public Universities in Ankara during the 2023-2024 academic year. For data analysis, exploratory factor analysis, confirmatory factor analysis, convergent and divergent (discriminant) validity, item analysis, and reliability analysis were employed. The scale was rigorously validated through exploratory factor analysis, confirmatory factor analysis, and other measures. As a result of the exploratory …

Prediction, Comparison And Visualization Of Premium Pricing Using Machine Learning Methods, Lal S Jan, Farzan Tashfeen, Mohid Hussain, Nadi M Alresheedi, Syed Muhammad Hassan Ahmer, Nahla M Albarkati

Yanbu Journal of Engineering and Science

This study investigates the efficacy of machine learning in forecasting and comparing health insurance premiums. The all-inclusive goal line is to improve the accuracy of premium pricing and minimize the manual labor associated with the traditional methods and present data trends in a logical manner. An open-source dataset of US medical premiums has been utilized and a systematic machine learning model in python programming language has been developed. This model took into account factors like age, bmi, smoking habits, and geographical location. The XGBoost model excels other models with an RMSE value of 0.349 and an adjusted R2 of 90.1% …

The Perception Of Ai Impact Of Academic Processes: A Study Of Student Perspectives, Nora Murphy, Lana Perkovic, Andzelika Wyka

International Undergraduate Journal of Health Sciences

Artificial Intelligence (AI) has emerged as a transformative technology with the potential to revolutionise education. This research aimed to comprehensively explore students’ perspectives on the integration of AI in educational settings, focusing on understanding its role, advantages, challenges, and expectations. The study analysed responses from a sixteen-question survey created through Google Forms administered online to 196 students from diverse academic backgrounds and educational levels enrolled across two Cork third-level institutions.

The demographic distribution of the respondents showed 44.4% aged 18-20 years old, 43.9% aged 21-23 years old, and 11.7% aged 24 and above, with 67.9% female respondents and 32.1% males. …

The Attitudes And Knowledge Of Organ Donation And The ‘Opt Out’ Consent System Among Irish Third Level Students., Rachel Webster, Emma Flynn, Tara O'Brien

International Undergraduate Journal of Health Sciences

Currently there are approximately 500 people in Ireland waiting for an organ donation while only approximately 280 transplants are carried out per year. While close to 80% of Irish people support organ donation it is estimated that only one-third of those are registered donors. This is the basis for the new ‘Opt Out’ policy within the ‘Human Tissue (Transplantation, Post-Mortem, Anatomical Examination and Public Display) Act 2024’ that has recently been signed into law (as of 28^th February 2024). This study aimed to investigate third-level students’ awareness of this new legislation and to determine if there would be an …

A Meta-Analysis Of The Relationship Between Estradiol, C-Reactive Protein, Interleukin-6 And Tumour Necrosis Factor-Alpha, And Their Association With Breast Cancer Prognosis, Keelin M. Crowley

International Undergraduate Journal of Health Sciences

This meta-analysis reviewed interleukin 6 (IL-6) levels across various tumour stages, compared transdermal and oral estradiol levels on IL-6 and C-reactive protein (CRP), and examined the IL-6 and tumour necrosis factor alpha (TNF-a) levels in healthy versus breast cancer patients. This analysis covers studies from 2003 to 2020.

Results: IL-6 can be used as a prognostic biomarker for breast cancer, as levels are seen to increase as the cancer stage advances. While transdermal estradiol does not have any significant effects on IL-6 or CRP, oral estradiol seemed to display an increase in. The baseline IL-6 levels differ between control subjects …

Audit Of The Impact Of The Pause In The National Screening Service For Breast Cancer During The Covid-19 Pandemic, Ava Coakley

International Undergraduate Journal of Health Sciences

In Ireland there is a free national screening service for breast cancer called BreastCheck. BreastCheck invites women aged fifty to sixty-nine to have screening mammograms once every two years to detect any densities in their breast mammogram which could indicate breast cancer. If densities are seen on a mammogram a breast core is sampled and sent to a histopathology laboratory where a part of the tissue is examined by a consultant pathologist using a microscope. Further tests can then be performed on this sample if it is diagnosed as breast cancer. Tests include immunohistochemistry and dual in-situ hybridisation (DISH). BreastCheck …

A Review Of Breast Implant Associated Anaplastic Large Cell Lymphoma (Bia-Alcl) In The Histopathology Laboratory In Cork University Hospital (Cuh), Ruth Purcell

International Undergraduate Journal of Health Sciences

Breast implantation is a common procedure for either breast reconstruction, following a mastectomy or for cosmetics. Approximately 10 million individuals have breast implants worldwide. Breast implants are composed of an outer silicone layer that are filled with either silicone gel or saline and have a lifespan of approximately 16 years (Quesada et al., 2018). When the implantation occurs, a fibrous capsule is naturally formed around the implant. However, it has become apparent in recent years that there is a link between the use of textured implants and a rare type of lymphoma. Breast Implant Associated- Anaplastic Large Cell Lymphoma (BIA-ALCL) …

Full Issue: The International Undergraduate Journal Of Health Sciences, Volume 5, Issue 1, July 2025

International Undergraduate Journal of Health Sciences

Full Issue: The International Undergraduate Journal of Health Sciences, Volume 5, Issue 1, July 2025.