Digital Commons Network^™

Macrophage-T Cell Interactions Promote Slamf1 Expression For Enhanced Tb Defense, G V R Krishna Prasad, Steven J Grigsby, Gideon A Erkenswick, Cynthia Portal-Celhay, Ekansh Mittal, Guozhe Yang, Samuel M Fallon, Fengyixin Chen, Thais Klevorn, Neharika Jain, Yuanyuan Li, Makedonka Mitreva, Amanda J Martinot, Joel D Ernst, Jennifer A Philips

2020-Current year OA Pubs

CD4+ T cells are crucial for protective immunity to intracellular pathogens. In addition to secreting cytokines, CD4+ T cells promote control of Mycobacterium tuberculosis infection through cognate interactions with macrophages, but the mechanism has been unclear. Here, we show that SLAMF1/CD150 is highly and uniquely induced in macrophages by antigen-specific interactions with CD4+ T cells. In macrophages, SLAMF1 enhances the generation of reactive oxygen species and restricts Mtb replication. Mtb-infection of mice promotes SLAMF1 expression specifically on infected macrophages, not uninfected bystanders. SLAMF1 expression depends on adaptive immunity and also autophagy. Moreover, Slamf1

Sepsis Restructures The Mitochondrial Calcium Uniporter Complex In The Lymphoid Tissues Of Mice And Humans, Xianghong Zhang, Jianguo Lin, Baobo Zou, Jack R Killinger, Andrew C Sayce, Thiagarajan Meyyappan, Zeyu Xiong, Melanie J Scott, Janet S Lee, Matthew R Rosengart

2020-Current year OA Pubs

Survivors of sepsis suffer from an elevated risk of premature death that is not explained by a higher burden of chronic diseases prior to the infection. Nearly 1 out of 4 survivors have persistent elevations of inflammation biomarkers, such as interleukin (IL) 6. These observations suggest that sepsis imparts durable changes to organismal biology. Eukaryotic life depends upon ATP and calcium (Ca

Gene Therapy Ameliorates Neuromuscular Pathology In Cln3 Disease, Ewa A Ziółkowska, Albina Jablonka-Shariff, Letitia L Williams, Matthew J Jansen, Sophie H Wang, Elizabeth M Eultgen, Matthew D Wood, Daniel A Hunter, Jaiprakash Sharma, Marco Sardiello, Robyn Reese, Alan Pestronk, Mark S Sands, Alison K Snyder-Warwick, Jonathan D Cooper

2020-Current year OA Pubs

CLN3 disease is a neuronopathic lysosomal storage disorder that severely impacts the central nervous system (CNS) while also inducing notable peripheral neuromuscular symptoms. Although considerable attention has been directed towards the neurodegenerative consequences within the CNS, the involvement of peripheral tissues, including skeletal muscles and their innervation, has been largely neglected. We hypothesized that, CLN3 deficiency could directly influence peripheral nerves and investigated the neuromuscular system in Cln3

Humanization Strategy Of The Public Urban Space In Cairo, Rania Badawy Shokry

Mansoura Engineering Journal

An accurate scientific definition of the term “humanization of cities” has not yet crystallized, which refers the term to the word from which it is derived. She is "human". Obviously, anything contrary to it is inhuman; starting from wild nature or a life entirely dependent on vehicles. If a person cannot dispense with vehicles when carrying out his daily activities, then here we know that the standard of humanization in a place is low. However, if the planning of a city or neighborhood takes into account the needs of the population and the human standard, then the city may reach …

Study Habits And Examination Anxiety As Correlates Of Academic Performance Among Secondary School Students In Kwara State, Nigeria, Oyedotun Dolapo Ilori, Falilat A. Okesina, Patrick O. Akerele, Ifeoluwa Blessing Michael

Buletin Konseling Inovatif

Examination anxiety and study habits seem to be a significant factor of academic performance. This study examined study habits and examination anxiety as correlates of academic performance among secondary school students in Kwara State, Nigeria. This study adopted a descriptive survey of correlational type. The population for the study consists of 235, 652 secondary school students, and the sample consists of 400 secondary school students. Two research questions were answered using frequency count, percentage and mean rank order while the three hypotheses formulated were tested using inferential statistics of Pearson’s Product Moment Correlation statistics (PPMC) and multiple regression analysis at …

Exploring Victorian Era Class And Culture: Representation Of The Working Class Through Joseph Skipsey's Poetry, Nathasya Josephine

International Journal of Undergraduate Research and Creative Activities

Representation of minorities has always been a problem in publication. This is especially true in Victorian society, where class stratification was rampant and class distinctions were marked as normal. As a result, many authors from underprivileged communities are overshadowed by the influential literary giants we now know as the Canons. This paper aims to shed light on one of the unknown voices representing Victorian working-class society. Specifically, it will discuss Joseph Skipsey, a working-class author who writes poems about his daily life and struggles as a miner. The focus will be on two of his poems: "Get Up" and The …

Essays On Freedom And Power, John Acton

Hannah Arendt Marginalia - All

New York : [Published by Noonday Press], 1955, [c1948]

Call #: New York : JC571 .A14 1955

Excerpted pages contains marginalia, underlining and marginal lining

PDF Information: 77 pages – 4.5 MB

Tank Chair [Book Review], Jj Pionke

Disability in LIS (DisLIS)

We are introduced to Nagi our wheelchair using assassin, and his adorable younger sister, as they try to figure out how improve the amount of time where he is awake.

Effects Of Plasma-Activated Water On Wheat: Germination And Seedling Development, Wafaa Abdulrazzaq Abdullah, Hadeel O. Ismael, Duaa A. Uamran, Hammad R. Humud

Karbala International Journal of Modern Science

The food sector must contend with issues such as pathogen resistance to some of the available chemical agents, environmental pollution, and climate change to provide healthy food for livestock and people. The application of atmospheric pressure plasma jets (APPJs) is one potential solution for such problems. Plasma is appropriate for effective surface decontamination regarding food products and seeds, surface decontamination, and achieving improved agricultural production yields. The impact of plasma-activated water (PAW) produced by plasma jet discharge (PJD) system on in vitro-cultivated wheat seeds is examined in this work. For this aim, a plasma jet system was constructed with a …

A New Case Of Kilquist’S Syndrome With A Novel Variant In Slc12a2 And A Brief Review Of The Literature, Hatice Yelda Yalçin, Yiğithan Güzin, Tayfun Cinletil, Berk Özyilmaz, Gamze Uzan, Melis Köse, Figen Baydan

Journal of Pediatric Genetics

Background: Kilquist syndrome (KILQS) is a recently characterized, rare disorder characterized by hearing loss, secretory dysfunction, gastrointestinal system (GIS) abnormalities, and neurological anomalies including hypotonia and global developmental delay. It is caused by variants in the SLC12A2 (Solute Carrier Family 12 Member 2) gene which encodes the Na-K-2Cl cotransporter isoform 1 (NKCC1). Objective: This study aims to contribute to genotype-phenotype correlations for SLC12A2 variants. Material and Methods: We evaluated a Turkish patient with a novel variant in SLC12A2 gene and reviewed all previously reported cases with Kilquist syndrome. Whole exome sequencing and Sanger sequencing were used as molecular genetic testing …

A Child With Non-Growth Hormone-Deficient Short Stature With Chromosome 2 Deletion Of 2q35-36.1: A Case Report And Literature Review Of Haploinsufficiency Of Epha4 Gene, Jun Sun, Ya Xiao, Shu-Qin Jiang, Yi-Fan Wang, Hong-Ru Zhang, Wei Wang

Journal of Pediatric Genetics

Non-growth hormone-deficient short stature is a group of growth developmental disorders with complex pathophysiological mechanisms involving multiple pathways, including abnormalities in the growth hormone/insulin-like growth factor 1 signal pathway. We report a 4-year-old girl with severe growth and developmental delay: her height was 91 cm (<–3 standard deviation [SD]), and her growth rate was 3 to 4 cm/year (<–2 SD). Growth hormone stimulation tests indicated a normal peak growth hormone level (11.1 μg/L), while insulin-like growth factor-1 levels were reduced (7.98 nmol/L, <–1SD). Whole exome sequencing and copy number variation analysis revealed a 3.19 Mb deletion at 2q35-q36.1 on chromosome 2, encompassing all coding regions of the Epha4 gene. This study suggests an association between Epha4 gene deletion and non-growth hormone-deficient short stature, highlighting the importance of further research on this gene and its related signaling pathways to understand the molecular mechanisms of the disease and potential therapeutic approaches.

Systematic Review About Clinical And Radiologic Manifestations In Patients With Fatco Syndrome, D’Karlo Yosue Dongo Cornejo, Wendy Alessandra Gutiérrez Baca, Maria Cristina Laso Salazar, Hugo Hernán Abarca-Barriga

Journal of Pediatric Genetics

FATCO syndrome (Fibular Aplasia, Tibial Camptomelia, Oligosyndactyly) is characterized by the presence of Fibula Aplasia, Tibial Campomelia and Oligosyndactyly. It is an autosomal dominant congenital genetic disorder, with an infrequent occurrence. This is the main reason behind the limited number of studies carried out to date, and the importance of carrying out this review to enhance the understanding of this syndrome. The objective of this review based on case reports is to describe and analyze the clinical and radiological characteristics of patients diagnosed with FATCO syndrome, in addition to demographic characteristics and concomitant anomalies. The databases used in this review …

Genotype First Approach As A Diagnostic Strategy For Precision Medicine In Moroccan Families With Nephronophthisis, Ourayna Batta, Imane J. Cherkaoui, Yasmina Rahmuni, Nada Amllal, Kenza Soulami, Abdelaziz Sefiani, Jaber Lyahyai

Journal of Pediatric Genetics

Nephronophthisis is a group of autosomal recessive kidney diseases characterized by chronic tubulointerstitial abnormalities leading to kidney failure. The incidence of nephronophthisis varies globally, and its genetic heterogeneity presents significant difficulties in diagnosis. Herein, we present a molecular diagnosis of four unrelated Moroccan families fulfilling the clinical criteria of nephronophthisis. As first diagnosis step, screening for a homozygous NPHP1 gene deletion, the most common mutation, was performed by using multiplex polymerase chain reaction. Additionally, clinical exome sequencing was carried out on patients in whom no NPHP1 deletion was identified. Three novel pathogenic variants in NPHP1, INVS, and NPHP4 genes were …

Sleep Disordered Breathing In Children With Achondroplasia: 17 Years’ Experience From A Multidisciplinary Team, Maria Jose Guerdile, Virginia Fan, Mariana Del Pino, Vivian Leske

Journal of Pediatric Genetics

The aim of this study was to describe sleep-disordered breathing (SDB) and treatment in children with achondroplasia (ACH). A retrospective longitudinal study was conducted at the Sleep Unit, Hospital de Pediatría Garrahan. Children with ACH, aged 0 to 18 years, referred for SDB due to clinical symptoms or foramen magnum stenosis (FMS) with at least one polysomnography (PSG) between 2002 and 2019 were included in the study. The primary outcomes included SDB typification and therapeutic interventions. We included 89 patients; 79.7% had one PSG, 13.4% had two PSGs, and 5.6% had three PSGs. The first PSG confirmed SDB in 65.16% …

Opportunities For Growth: A Metacognitive Self-Talk Strategy That Improves Classroom Unity And Academic Attitudes, Sera Anello, Michael J. Haslip

Journal of Practitioner Research

This teacher action research study describes the development and application of the opportunities for growth teaching method to increase learner motivation, persistence, cooperation and positive self-talk among primary school students. The approach was implemented with 30 fourth graders in a Philadelphia public school classroom to foster unity, support attitudes toward academics and participation, redefine failure, and reframe challenges. Before this intervention, most of the students lacked self-regulation, self-awareness, and relationship skills needed to thrive. This study investigates how and to what effect the opportunities for growth approach shifts students’ language and mindset about academic and social challenges. Qualitative data was …

Teacher Inquiry: How Mathematics Discourse And Hands-On Learning Impact Student Outcomes And Teacher Attitudes, Mary-Katherine Miller

Journal of Practitioner Research

In this inquiry, the teacher worked alongside a university mentor to develop, monitor, and analyze the teacher’s wonderings. In a 3rd grade classroom, the teacher wanted to explore how hands-on and discourse strategies could impact mathematics achievement for all students. Specifically, the teacher explored how utilizing hands-on activities and discourse strategies in collaborative groups could lead to increased engagement and better outcomes for her exceptional student education (ESE) population in learning multiplication and division. Throughout the inquiry, the teacher used checklists, anecdotal notes, and student exit ticket scores to monitor student progress. At the end of the inquiry cycle, the …

Expanding The Role Of Embodiment And Teacher Noticing In Units Coordination And Construction, Claudia Bertolone-Smith, Jonathan Troup, Liza Bondurant, Diana Moss, Hortensia Soto

Journal of Practitioner Research

We aim to expand units coordination and construction assessment by examining the significance of embodiment and teacher noticing, especially in relation to recent developments in equitable mathematics teacher noticing research. We outline our approach as mathematics teacher educators with a wide range of expertise, wherein we investigated how prospective elementary mathematics teachers (PTs) notice students' units construction and coordination through embodied actions and the impact of incorporating a focus on embodiment in assessment. We also address how expanding the understanding of units coordination and construction assessment through embodied noticings can create more equitable classroom spaces. The study emphasizes the need …

Agency Protocol: A Decentralized Trust-Building System Using Domain-Specific Merit And Economic Stakes To Incentivize Promise-Keeping In Agent-To-Agent Interactions, David Joseph

Defensive Publications Series

The Agency Protocol defines a decentralized trust infrastructure in which autonomous agents cooperate by issuing cryptographically‑signed, domain‑scoped promises and verifiable assessments. Each promise carries a dual‑component stake—an at‑risk credit deposit and a non‑refundable operational‑cost fee—that is locked in content‑addressed storage and returned or slashed according to assessment consensus. Assessments are merit‑weighted; an agent’s merit is a non‑transferable, domain‑specific reputation score updated by matrix‑factorized aggregation of historical outcomes, while credits form a fully transferable internal currency. Merit discounts future stake requirements, creating a positive feedback loop that makes honest behaviour utility‑maximising.

External facts enter the system through a decentralised oracle …

“Try, Start, Do It”: Phil Zimbardo And The Heroes’ Square Foundation, Györgyi Orosz

Heroism Science

This article pays tribute to the life and legacy of Philip Zimbardo, emphasizing his transformative influence in Hungary through education, social engagement, and the science of heroism. The journey began with a 2012 invitation that brought Zimbardo to Budapest, ultimately leading to the foundation of the Heroes’ Square (Hősök Tere) initiative. His message—that heroism is not reserved for the exceptional but is accessible and teachable—became the core of nationwide programs focused on mindset, intervention behavior, and social responsibility. Zimbardo’s influence went beyond academia; he inspired personal and institutional change. The foundation’s programs, such as teacher trainings, the Hero School, and …

Enterobacter Cloacae As A Rare Cause Of Cerebral Abscesses In A Neonatal Late-Onset Sepsis – A Case Report And Literature Review With Focus On Risk Factors, Diagnostics And Treatment, Yıldız Yıldırım, Ruy Perez, Rüdiger Wentzell, Clemens Andrée, Martin Weinzierl, Norbert Utz, Tim Niehues

Journal of Pediatric Infectious Diseases

Late-onset sepsis (LOS; sepsis occurring after the first 72 hours of life) increases the morbidity and mortality of premature neonates, especially those with very-low-birth weight (≤1500g). In LOS, Enterobacter cloacae has been rarely described as a cause of secondary brain abscesses. Our case report summarizes important aspects of cerebral abscesses due to an E. cloacae sepsis in a preterm neonate. Our patient received surgical abscess drainage and rational antibiotic treatment employing prolonged meropenem infusions plus fosfomycin and subsequent treatment with oral trimethoprim/sulfamethoxazole. Furthermore, we present a review of the current literature from 2009-2022, comparing cases similar to our case.

Magnitude And Factors Associated With Mortality Of Neonates Admitted To Intensive Care Unit In Northern Ethiopia: Hospital-Based Cross-Sectional Study, Gebrhud Berihu Haile, Tensay Kahsay Weldegebreal, Desta Hailu Aregawi, Daniel Birhane Berhe, Tomas Amare Abraha

Journal of Pediatric Infectious Diseases

Objectives: Neonatal mortality is a global burden both in developed and developing countries. Marked disparities exist across countries. In Ethiopia, the neonatal mortality rate is unacceptably high. Even though some published research exists, there is a lack of data regarding the magnitude and factors associated with mortality in neonates. The aim of this study was to assess the magnitude and factors associated with mortality in neonates admitted to intensive care units in northern Ethiopia. Methods: A cross-sectional study was employed among 325 neonates admitted to intensive care units in public hospitals from October 2021 to May 2022. Systematic random sampling …

Investigating Respiratory Viral Pathogens In Pediatric Age Groups, Yaser Ali Hussein Musawa, Fatma Esenkaya Taşbent, Mehmet Özdemir

Journal of Pediatric Infectious Diseases

Objective: Respiratory viral infections are the leading causes of morbidity and mortality in children. Acute respiratory infections account for approximately 20% of childhood fatalities. This study aimed to retrospectively investigate the respiratory viral agents and epidemiological characteristics, in pediatric patients. Methods: The study included pediatric patients, aged 0-18 years. A retrospective analysis was conducted on 5,253 samples sent to the microbiology laboratory with suspected respiratory tract infection between January 1, 2020 and December 31, 2023. Sixteen different viral agents were investigated in samples using multiplex PCR. The enrolled patients were divided into three groups. Positive results were examined in terms …

Epidemiological Characteristics Of Mycoplasma Pneumoniae Epidemic Among Children In Ningbo, China, 2022-2023, Fei Xu, Yefang Ke, Fei Li, Wenbo Lu, Junhua Wu, Wenyuan Liu

Journal of Pediatric Infectious Diseases

Objective Following the full relaxation of COVID-19 control measures in China at the end of 2022, there was a resurgence of pediatric Mycoplasma pneumoniae pneumonia (MMP) outbreaks. Methods We performed a retrospective study of children with M. pneumoniae pneumonia who were admitted to the Women and Children's Hospital of Ningbo University between January 2022 and December 2023. Demographic and clinical characteristics and proportion of A2063G/A2064G mutant train were compared between 2022 and 2023. Results Among the 13013 children hospitalized with pneumonia in 2022 and 2023, M. pneumoniae infections were identified in 4889 cases (37.57%). Notably, the positive rate of M. …

Dynamics Of Human Adenovirus In Hospitalized Children With Acute Respiratory Tract Infection During 2014-2022 In Hubei Province, China, Song Yi, Juan Du, Wan-Xue Zhang, Xin-Rui Wang, Yi-Guo Zhou, Xing-Wen Hu, Qing-Bin Lu

Journal of Pediatric Infectious Diseases

Objective: The study mainly aimed to explore the impact of Human adenovirus (HAdV) detection by two-child policy and coronavirus disease 2019 (COVID-19) epidemic in China. Methods: Hospitalized children with ARTI were enrolled in Maternal and Child Health Hospital of Hubei Province from January 2014 to June 2022, whose clinical data were collected retrospectively. The effects of two-child policy and COVID-19 pandemic on the detection of HAdV were analyzed. Results: Among 100215 hospitalized children with ARTI, the positive rate of HAdV was 1.93% with the peak in 2019. After the implementation of two-child policy, the positive rate of HAdV during 2017-2019 …

Association Of Respiratory Viruses With Febrile Seizures: A Two-Year Observational Study, Ivana Clara Trittler-Ugidos, Fernando Paredes-Carmona, Núria Visa-Reñé

Journal of Pediatric Infectious Diseases

Objective: This study aims to explore the association between respiratory viruses and febrile seizures (FS), and to analyze the impact of these viruses on the type and management of FS. Methods: We conducted a retrospective, single-center study of 49,445 emergency cases from September 2021 to December 2023. Among these, 266 patients with FS were identified. Nasopharyngeal swabs were performed to detect respiratory viruses. We categorized FS into simple febrile seizures (SFS) and complex febrile seizures (CFS) based on established criteria. Results: Of the 266 FS cases, 150 had a nasopharyngeal swab and 76.6% were positive for respiratory viruses. The most …

Prognostic Value And Clinical Influence Of Long Non-Coding Rna Small Nucleolar Rna Host Gene 1 Expression In Pediatric Pneumonia, Xin Wang, Jiajia Xu, Jingjing Han

Journal of Pediatric Infectious Diseases

Objective: Severe pediatric pneumonia is characterized by acute onset and rapid progression, posing a serious threat to patients' lives. Accurate assessment of the severity of pneumonia is essential for clinical decision-making and prognostication. Studies of acute lung injury and lung cancer have revealed a significant increase in the expression of the long non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) in cells, suggesting that SNHG1 is likely to play an important role in the progression of lung disease. Methods: 72 children with mild pneumonia, 58 children with severe pneumonia and 135 healthy children were selected as study subjects. …

Utility And Impact Analysis Of Inpatient Pediatric Physiologic Monitoring, Anand Gourishankar, Monaliza Evangelista, Misti Ellsworth, Jean Hsu

Journal of Pediatric Intensive Care

Objective: This study aimed to study the practice and effect of monitoring pediatric patients in the length of stay (LOS). Methods: We performed a prospective, observational study of pediatric patients in the general ward from October to December 2016. We have recorded the use of cardiac, pulse-oximeter, or both, and as per physician order at time of patient admission. We have studied the proportions of monitoring at different patient groups. We have applied linear regression model to investigate the relationship between LOS and cardiopulmonary monitoring, orders, and medical complexity. Results: Among 399 patients, patients with cardiac and pulse oximeter monitoring …

A Decade Of Pediatric Intensive Care Outreach And The Deteriorating Child—The Relationship Between Dose And Outcomes In A Tertiary Children's Hospital, Lynette Kirby, Jayshan Chagan, Catherine Adams, Natalie Duns, Michael Haddad, Sarah Pearson, Oliver Tegg, Chong Tien Goh

Journal of Pediatric Intensive Care

Objectives: The aim of this study is to evaluate the amalgamation and maturation of a Paediatric Intensive Care Outreach Service (PICOS) with a Rapid Response System (RRS) and associated outcomes over a ten year period. Methods: Single centre retrospective study analysing patient outcomes within the context of significant organisational changes introducing a track & trigger RRS called Between the Flags (BTF), and evolution of this system to electronic observation charting and alerts (eBTF) in a tertiary metropolitan children’s hospital. Children on inpatient wards who required urgent activation of the RRS and admission to the Paediatric Intensive Care Unit (PICU) between …

Use Of Continuous Eeg Monitoring And Short-Term Outcomes In Critically Ill Children, Xiuhua Liang Bozarth, Pin-Yi Ko, Hao Bao, Nicholas S. Abend, R. Scott Watson, Pingping Qu, Leslie A. Dervan, Lindsey A. Morgan, Mark Wainwright, John K. Mcguire, Edward Novotny

Journal of Pediatric Intensive Care

Objectives: This study aimed to compare short-term outcomes at pediatric intensive care unit (PICU) discharge in critically ill children with and without continuous EEG (cEEG) monitoring. Methods: We retrospectively compared 234 patients who underwent cEEG with 2294 patients without cEEG. Propensity score matching was used to compare patients with seizures and status epilepticus between cEEG cohort and historical cohort. Results: The EEG cohort had higher in-hospital mortality, worse Pediatric Cerebral Performance Category (PCPC) scores, and greater PCPC decline at discharge. In patients with status epilepticus, PCPC decline was higher in the cEEG cohort. Conclusions: PCPC decline at PICU discharge was …

Multisystem Inflammatory Syndrome In Children Associated With Covid-19 Infection: A Comprehensive Review, Alejandra Isabel Meza-Contreras, Marcelo Nicolas Galdos-Bejar, Raffo Escalante-Kanashiro

Journal of Pediatric Intensive Care

Objectives: The Multisystem Inflammatory Syndrome in Children (MIS-C) is a post-infectious syndrome associated with COVID-19 disease in children. The aim of this study is to conduct a thorough review to assist healthcare professionals in diagnosis and management of this complication of COVID-19 disease in children Material and Methods: A thorough systematic review was conducted through an on-line search based on MIS-C with the primary focus on epidemiology, clinical characteristics, diagnosis, pathophysiology, management and long-term follow-up. Results: This syndrome is characterized by an exaggerated and uncontrolled release of pro-inflammatory cytokines involving dysfunction of both innate and adaptive immunity. In this review, …