Digital Commons Network^™

Effects Of The Gut Microbiota On Placental Angiogenesis And Intrauterine Growth In Gnotobiotic Mice, Reyan Coskun, Zenan L Chang, Athziri Marcial Rodríguez, Haoxin Liu, Jiye Cheng, Yael Alippe, Michael S Diamond, Jeffrey I Gordon

2020-Current year OA Pubs

Environmental causes of intrauterine growth restriction (IUGR) remain poorly characterized. Here, we compare germ-free (GF) and conventionally raised (CONV-R) mice to assess the effects of the gut microbiota on placental/fetal development at embryonic day (E)11.5 (end of placentation) and E17.5 (near term). Pregnancy- and microbiota-associated changes in gene expression occur along the gut, including those related to angiogenesis, while bacterial composition and fermentation activity remain stable. Placental weights at E11.5 and fetal weights at E17.5 are significantly reduced in GF animals. Compared to CONV-R dams, the GF maternal decidua exhibits similar vascular histomorphometric features at E11.5 and E17.5, and numbers …

Cd206+Il-4rα+ Macrophages Are Drivers Of Adverse Cardiac Remodeling In Ischemic Cardiomyopathy, Qiongxin Wang, Mohamed Ameen Ismahil, Yujie Zhu, Gregg Rokosh, Tariq Hamid, Guihua Zhou, Steven M. Pogwizd, Sumanth D. Prabhu

2020-Current year OA Pubs

BACKGROUND: The role of cardiac CD (cluster of differentiation) 206

METHODS: Adult C57BL/6 mice underwent nonreperfused myocardial infarction to induce HF. Macrophages in murine and human hearts were profiled using flow cytometry and immunostaining. In vivo myeloid-specific IL-4Rα deletion and intramyocardial macrophage adoptive transfer defined the functional effects of macrophages polarized by IL-4 (M[IL-4]). Antisense oligonucleotides were used for in vivo IL-4Rα gene silencing in mice.

RESULTS: CD206

CONCLUSIONS: Cardiac CD206

A Phase I Trial Of Evorpacept, Lenalidomide And Rituximab For Patients With B-Cell Non-Hodgkin Lymphoma, Paolo Strati, Lei Feng, Andrey Tyshevich, Darya Shavronskaya, Julia Alesse, Noel English, Elizabeth Sheehan, Nikita Syzrantsev, Alexander Nesmelov, Tony Z Zhuang, Dai Chihara, Jason R Westin, Sairah Ahmed, Luis E Fayad, Jared Henderson, Kylie Dent, Elizabeth Mcchesney, Sattva S Neelapu, Christopher R Flowers

Faculty, Staff and Student Publications

Introduction: SIRPα+ macrophages can mediate resistance to lenalidomide and rituximab (R2) in patients with B-cell non-Hodgkin lymphoma (B-NHL). Evorpacept (ALX148) is a novel CD47 blocker that abrogates interactions between lymphoma cells and SIRPα+ macrophages.

Methods: Adult patients with B-NHL who had received at least 2 prior lines of systemic therapy were included in this single arm phase I study (NCT05025800). Evorpacept was administered intravenously (IV), in a 28-day cycle, until progression, at two dose levels (DL): 30 mg/Kg on day (D) 1 and D15 (DL1), or 60 mg/Kg on day 1 (DL2); rituximab 375 mg/m2 IV was given …

Transforming Cancer Care: A Narrative Review On Leveraging Artificial Intelligence To Advance Immunotherapy In Underserved Communities, Victor M. Vasquez Jr., Molly Mccabe, Jack C. Mckee, Sharon Siby, Usman Hussain, Farah Faizuddin, Aadil Sheikh, Subramanian Dhandayuthapani, Shrikanth Gadad, Jessica Chacon

School of Medicine Publications

Purpose: Cancer immunotherapy has transformed oncology, but underserved populations face persistent disparities in access and outcomes. This review explores how artificial intelligence (AI) can help mitigate these barriers. Methods: We conducted a narrative review based on peer-reviewed literature selected for relevance to artificial intelligence, cancer immunotherapy, and healthcare challenges, without restrictions on publication date. We searched three major electronic databases: PubMed, IEEE Xplore, and arXiv, covering both biomedical and computational literature. The search included publications from January 2015 through April 2024 to capture contemporary developments in AI and cancer immunotherapy. Results: AI tools such as machine learning, …

An Arc Of Time Through Crime: Representations Of Gypsies And Travellers In Police Killings, Coretta Phillips, Becky Taylor, Zoë James

School of Law, Humanities and Social Sciences

This paper examines newspaper stories reporting on the killings by Gypsy and Traveller offenders of PC Leslie Meehan in 1960 and PC Andrew Harper in 2019. These media representations are used as heuristic devices to explore differing media discourses about this white minority ethnic group. Sixty years apart, these stories demonstrate supportive media commentary in the earlier period and more corrosive coverage in the recent period. Making a contribution to historical criminology and its consideration of race, this paper draws from extensive archival analysis and the extant literature. It highlights the political-economic significance of home ownership, the partial inclusion of …

3612 Broadway Partners Llc V. Moreno

All Decisions

A landlord's motion for a default judgment was denied, and the court granted a tenant's motion for leave to file a late answer in a non-payment proceeding. The court reasoned that a meritorious defense is not an essential element for a late answer motion when no default judgment has been entered. The court was persuaded by the short, eight-day delay between the tenant's counsel appearing and filing the motion. Citing a lack of prejudice to the landlord and the public policy of resolving cases on their merits, the court granted the tenant's motion.

Seeing Bias Through Eye Movements: Investigating Empathy And Engagement With Authentic And Altered Refugee Imagery, Reem Albaghli, Akshay Sunil Gurnaney, Nada Attar

Faculty Research, Scholarly, and Creative Activity

This study investigates perceptual biases in responses to Syrian and Ukrainian refugee images using human-computer interaction (HCI) techniques. We hypothesized that media portrayals might shape empathy and influence both biases and donation behavior. Participants viewed both authentic and face-swapped images, with eye-tracking data capturing pupil size and decision-making patterns. In Experiment 1, participants' eye-tracking data and donation behavior indicated higher engagement and donations for authentic images, suggesting a preference for unaltered images without ethnicity-based bias. Experiment 2 explored this further by presenting cropped refugee faces alongside neutral or intellectual art, asking participants to choose the art that best matched each …

Lessons In Longevity From Blood Stem Cells Under Protein Stress, André Catic

Center on Aging Staff Publications

Blood stem cells are among the body's longest-living cells despite being highly vulnerable to proteotoxic damage, which accelerates their aging. To maintain protein homeostasis (proteostasis), hematopoietic stem cells (HSCs) employ mechanisms such as reduced translation rates, high chaperone activity, autophagy, and selective protein degradation. These strategies mitigate protein misfolding, maintain quiescence, and preserve regenerative potential. Disruptions in proteostasis can lead to the elimination of impaired HSCs through differentiation or apoptosis, ensuring the integrity of the stem cell pool. Due to the systemic impact of the blood on aging and its experimental and clinical accessibility, investigating HSC proteostasis provides insights into …

Structural Variants: Mechanisms, Mapping, And Interpretation In Human Genetics, Shruti Pande, Moez Dawood, Christopher M Grochowski

Faculty, Staff and Students Publications

Structural variations (SVs) represent genomic variations that involve breakage and rejoining of DNA segments. SVs can alter normal gene dosage, lead to rearrangements of genes and regulatory elements within a topologically associated domain, and potentially contribute to physical traits, genomic disorders, or complex traits. Recent advances in sequencing technologies and bioinformatics have greatly improved SV detection and interpretation at unprecedented resolution and scale. Despite these advances, the functional impact of SVs, the underlying SV mechanism(s) contributing to complex traits, and the technical challenges associated with SV detection and annotation remain active areas of research. This review aims to provide an …

Xpert Mtb/Rif Ultra Assay For Pulmonary Tuberculosis And Rifampicin Resistance In Adults And Adolescents, David J Horne, Jerry S Zifodya, Adrienne E Shapiro, Elizabeth Chandler Church, Jonah S Kreniske, Alexander W Kay, Katie Scandrett, Karen R Steingart, Yemisi Takwoingi

Faculty, Staff and Students Publications

Background: Xpert MTB/RIF Ultra (Xpert Ultra) is a molecular World Health Organization (WHO)-recommended rapid diagnostic test that simultaneously detects tuberculosis and rifampicin resistance. This review updates a comparative accuracy Cochrane review of Xpert MTB/RIF and Xpert Ultra as Xpert Ultra has replaced Xpert MTB/RIF.

Objectives: To determine the diagnostic accuracy of Xpert MTB/RIF Ultra (Xpert Ultra) for detecting pulmonary tuberculosis and rifampicin resistance in adults and adolescents with presumptive tuberculosis based on signs or symptoms or with an abnormal chest x-ray suggestive of tuberculosis.

Search methods: We searched seven databases including CENTRAL, MEDLINE, and Embase, plus two trial registers (ClinicalTrials.gov …

Cell Type-Specific Purifying Selection Of Synonymous Mitochondrial Dna Variation, Caleb A Lareau, Patrick Maschmeyer, Yajie Yin, Jacob C Gutierrez, Ryan S Dhindsa, Anne-Sophie Gribling-Burrer, Sebastian Zielinski, Yu-Hsin Hsieh, Lena Nitsch, Veronika Dimitrova, Benan Nalbant, Frank A Buquicchio, Tsion Abay, Robert R Stickels, Jacob C Ulirsch, Patrick Yan, Fangyi Wang, Zhuang Miao, Katalin Sandor, Bence Daniel, Vincent Liu, Paul L Mendez, Petra Knaus, Manpreet Meyer, William J Greenleaf, Anshul Kundaje, Redmond P Smyth, Mathias Munschauer, Leif S Ludwig, Ansuman T Satpathy

Duncan NRI Faculty and Staff Publications

While somatic variants are well-characterized drivers of tumor evolution, their influence on cellular fitness in nonmalignant contexts remains understudied. We identified a mosaic synonymous variant (m.7076A > G) in the mitochondrial DNA (mtDNA)-encoded cytochrome c-oxidase subunit 1 (MT-CO1, p.Gly391=), present at homoplasmy in 47% of immune cells from a healthy donor. Single-cell multiomics revealed strong, lineage-specific selection against the m.7076G allele in CD8+ effector memory T cells, but not other T cell subsets, mirroring patterns of purifying selection of pathogenic mtDNA alleles. The limited anticodon diversity of mitochondrial tRNAs forces m.7076G translation to rely on wobble pairing, unlike the Watson-Crick-Franklin pairing …

P250306e_Uss0073_Twip Defpub Freeform- Phase-Value - Parametermatrix For Sending/Receiving Array, Christian A. Mohr, Mark Rode, Marco Dannemann

Defensive Publications Series

The invention relates to an ultrasonic measurement system comprising: a phased-array transmit antenna (1) comprising a plurality of ultrasonic transducers (PMUTs), a phased-array receive antenna (2), wherein the receive antenna (2) is distinct from the 5 transmit antenna (1), a control unit (3) configured to assign to each transducer of the transmit antenna (1) a signal with an individually adjustable phase value, wherein the phase values are defined by a transmit parameter matrix (P_TX), wherein the control unit (3) is further configured to transmit multiple orthogonal codes 10 (C₁, C₂, ..., Cₙ) simultaneously superimposed on the same frequency band, with …

Fictitious Data-Based Watermarking System

Defensive Publications Series

Systems and methods are provided for watermarking via unique synthetic datasets. A candidate model may be trained with a poison dataset including synthetic information. The synthetic information may relate to a fictitious place, person, or scenario, for example. A set of one or more inference questions associated with the poison dataset may be determined. The candidate model may be tested based on the set of one or more inference questions. A confidence may also be generated. The confidence may be associated with one or more identification metrics associated with the candidate model.

Method, System, And Computer Program Product For Large Language Model (Llm)-Enabled Searching, Jia Yi Kuo, Jianyang Huang, Karthik Gopalakrishna, Bhuvanjeet Singh Gandhi, Paromita Guha, Ashutosh Kumar Chandel, Arpita Agrawal, Ritu Saxena

Defensive Publications Series

A method includes: chunking each resource into chunks; inputting the chunks into a model; for each chunk, generating an embedding vector; receiving a query message from a user device; inputting the query message into the model; generating a query embedding vector for the query message; executing a semantic search on the query embedding vector by: inputting the query embedding vector and the embedding vector for each chunk to the model; for each chunk, generating a chunk similarity score; determining a subset of chunks based on the chunk similarity score for each chunk of the resource; inputting the subset of chunks …

Multi-Agent Orchestration System With Self-Correcting Cognitive Assembly Line For Enterprise Ai Automation, Adrian Angeriz Silvano

Defensive Publications Series

This disclosure describes a novel approach to enterprise business automation through a catalog-based AI agent deployment system combined with intelligent backend orchestration that eliminates manual technical configuration requirements.

The disclosed system introduces a revolutionary "Cognitive Assembly Line" architecture comprising four specialized AI agents working in sequence with automatic self-correction capabilities, combined with three Intelligence Adaptive Orchestrators (IAOs) that provide enterprise context awareness.

Key technical innovations include: (1) Sequential processing through four specialized agents with self-correction loops, (2) Intelligent OIA routing based on function requirements, (3) Cost-optimized hybrid architecture using local VRAM infrastructure, (4) Zero-configuration deployment for non-technical users, and (5) …

Acceptance Analysis Of The Employee Management Information System (Simpeg) At The Ministry Of Tourism Using Utaut, Muhammad Alfa Tanzil, Istiadi Soenarto

Jurnal Administrasi Bisnis Terapan

The Employee Management Information System (SIMPEG) is utilized by the Ministry of Tourism to support digital personnel administration management. Although SIMPEG has been implemented, its success largely depends on employees’ acceptance of the system. This indicates that system availability alone does not ensure successful implementation without an understanding of the factors influencing its use. This study aims to analyze the factors affecting the acceptance of SIMPEG by applying the Unified Theory of Acceptance and Use of Technology (UTAUT) model. A quantitative approach was used, with data analyzed through Partial Least Squares Structural Equation Modeling (PLS-SEM). Data were collected from 67 …

Augustine Of Hippo, Peter Brown

Hannah Arendt Marginalia - All

Berkeley, University of California Press, 1967

Call #: BR1720.A9 B7

Contains underlining and marginal lining

PDF Information: 6 pages – 2 MB

Reflections On The French Revolution, Edmund Burke

Hannah Arendt Marginalia - All

London, J. M. Dent & Sons / New York, E. P. Dutton & Co., 1935

Call #: AC1 .E8 no.460

Contains marginalia, underlining and marginal lining.

PDF Information: 81 pages – 35mb

Burke’S Politics: Selected Writings And Speeches On Reform, Revolution, And War, Edmund Burke

Hannah Arendt Marginalia - All

New York, A.A. Knopf, 1949.

Call #: DA506 .B85 1949

Contains marginal lining and endpaper notes

PDF information – 73 pages – 6MB

Shakespearean Tragedy: Hamlet, Othello, King Lear, Macbeth, A. C. Bradley

Hannah Arendt Marginalia - All

New York: Meridian Books, 1955

Call #: PR2983 .B7 1955

Marginalia, underlining and marginal lining.

PDF Information: 25 pages – 9mb

Predictors Of Sleep Duration In Undergraduate Students Attending A Health Sciences University In Japan, Aaron M. Eakman, Yuki Kawakatsu, Miki Takahata, Daisuke Kudo, Shinji Satake, Toshiaki Sato

Internet Journal of Allied Health Sciences and Practice

Background: Inadequate sleep is a pressing public health concern contributing to absenteeism and poor school performance, especially in health sciences students. In this study we investigated the sleep quality and duration of undergraduate students in a prefectural university of health sciences program and explored factors explaining sleep duration (i.e., < 6 hours per night vs > 6 hours) using multiple variable logistic regression.

Method: This cross-sectional survey study included 369 nursing, occupational therapy and physical therapy students who completed Japanese versions of the Pittsburg Sleep Quality Index, in addition to well validated sleep-related and mental health-related assessments.

Results: We found just 11.7% of the …

A National Study Of Opioid Knowledge Of Physical Therapy Professionals, Shelene Thomas, John Kiesel, Steven G. Kinney, Isain Zapata

Internet Journal of Allied Health Sciences and Practice

Purpose: Deaths from opioid overdoses persist as the leading preventable cause of death in the United States. Musculoskeletal pain remains the primary symptom for opioid prescription. Physical therapists (PTs) and physical therapy assistants (PTAs) provide non-prescription pain management strategies to people with musculoskeletal pain. Currently, there lacks research quantifying opioid overdose management knowledge possessed by PTs, PTAs, and their respective students. The purpose of this study was to quantify opioid overdose knowledge by PTs, PTAs, and their respective students, collectively termed physical therapy professionals (PTP). Methods: The electronic survey included several demographic characteristics and the opioid overdose knowledge scale (OOKS) …

Increasing Clinical Placements For Occupational Therapy In A Social Services Setting: Innovations For Practice, Martin Fitzgerald, Becky Antich, Ele Grimwood

Internet Journal of Allied Health Sciences and Practice

Purpose: The provision of undergraduate clinical placements to support Allied Health education has always been a challenge. However, in the last few years, the mismatch between undergraduate students and available placements has become acute. This paper describes how an undergraduate occupational therapy programme and a Metropolitan Council provider of social services worked together to overcome these challenges. The aim was to enhance inter-institutional cooperation and placement educator support and to increase placement opportunities. Method: A series of meetings between the university and the host institution identified barriers and opportunities to placement expansion. For the host institution, these included the absence …

Impact Of Self-Selected Self-Care Activities On Perceived Stress And Resilience Of Doctor Of Physical Therapy Students, Leslie F. Taylor, Niamh M. Tunney, Lisa Fraher

Internet Journal of Allied Health Sciences and Practice

Purpose: To assess the impact of self-selected self-care activities, supported by four interspersed reflection prompts, on the perceived stress and resilience of Doctor of Physical Therapy (DPT) students over 12 weeks. Methods: This exploratory study used a convergent parallel mixed-methods design. Participants included third-semester DPT students (n=37; Class of 2024) enrolled in an eight-semester program.100% provided consent, with an 89% response rate (n=32). Quantitative pre- and post-measures included the Perceived Stress Scale (PSS), the Connor-Davidson Resilience Scale (CD RISC-25), and a researcher-developed survey which asked students to identify their current self-care activities from a list of physical, psychological, emotional, spiritual, …

Educational Objectives Of Doctor Of Athletic Training (Dat) Degree Programs: A Document Review, Matthew J. Rivera, Samuel Orr, Lindsey E. Eberman

Internet Journal of Allied Health Sciences and Practice

Purpose: The Doctor of Athletic Training (DAT) degree is one postprofessional educational pathway that could provide athletic trainers advancement in clinical, leadership, and scholarship practice. Although some is known about the motivations to pursue and the anticipated learning outcomes from both clinical and educational settings, we sought to explore the stated learning outcomes DAT programs publicly state related to advanced clinical practice, advanced practice leadership, scholarship, and specific programmatic uniqueness. Methods: We used a document review of publicly available websites. We analyzed eight DAT program websites that were available as of September 2023. Using deductive coding, from the professional …

Analysis Of Ringside Physician Stoppages In Professional Mixed Martial Arts., Andy Suarez, Justin Braun, Corey Peacock, Gabriel J. Sanders

Internet Journal of Allied Health Sciences and Practice

Modern Mixed Martial Arts (MMA), popularized globally by the Ultimate Fighting Championship (UFC) since 1993, initially faced significant concerns regarding fighter safety but improved considerably following the introduction of comprehensive regulatory measures. Despite these enhancements, MMA continues to carry substantial risk, particularly evident in bouts concluded by referee or medical stoppages. These stoppages are critical safety mechanisms protecting fighters and providing valuable insights into injury trends. This study specifically investigates MMA bouts stopped by ringside physicians due to medical concerns or observed injuries, emphasizing potential differences in these stoppages between male and female fighters. The methods involved the analysis of …

Respiratory Syncytial Virus, Tahani Ali Alshammari, Ali Mohi Alqahtani

Internet Journal of Allied Health Sciences and Practice

Abstract:

Respiratory Syncytial Virus (RSV) is a highly contagious pathogen causing significant respiratory infections across all age groups, with heightened severity in infants and the elderly. This paper provides a comprehensive overview of the virus's epidemiology, the associated dangers, and current therapeutic interventions. Historical data identifies RSV as a primary cause of respiratory hospitalizations in infants and ageing populations, with reinfection common throughout life. After several trials and molecular diagnostics to find treatment options, various vaccines, antiviral drugs, and monoclonal antibodies have been licensed for use in various parts of the world. Recent studies explore the importance of passive immunization …

Evaluating Assistive Technologies In High Acuity Patients: A Scoping Review With Swot Analysis, Mallory Kargela Pt, Dpt, Amanda Anderson Pt, Dpt, Lindsay Anderson Pt, Dpt, Tian Gong Pt, Dpt, Kylie Scott Pt, Dpt, Edd

Internet Journal of Allied Health Sciences and Practice

Purpose: This publication examines the application of assistive technologies (AT) in high-acuity environments, including intensive care units (ICUs), acute care hospitals, and others. The aim is to systematically explore and synthesize the use of AT across these settings, identifying key strengths, weaknesses, opportunities, and threats (SWOT) associated. Methods: A literature search was conducted from 2016 to 2023 using PubMed, Tufts and Midwestern University Library databases. Search terms included ('physical therapy' OR 'physiotherapy') AND ('critically ill' OR 'acute' OR 'intensive care') AND ('assistive technology' OR 'technology' OR 'telerehabilitation' OR 'telePT' OR 'functional electrical stimulation' OR 'FES' OR 'cycle ergometry' …

Barriers And Facilitators To Occupational Therapy For The Frail Older Person Within Primary Care In Belgium, Anne Ledoux, Stijn De Baets, Thérèse Van Durme, Patricia De Vriendt, Dominique Van De Velde, Sophie Thunus

Internet Journal of Allied Health Sciences and Practice

Introduction: The population is quickly aging in Belgium and there is an increasing number of older frail adults. Occupational therapy (OT) in primary care (PC) favors the stay-at-home of frail older persons through its preventive action on the person, the environment, and/or the task. However, OT is not well implemented in Belgian PC. We aimed to investigate the implementation of OT, to support the frail older person living at home, within primary care in Belgium. Methods: We performed a secondary thematic analysis, based on data collected during an implementation study of an OT guideline for this population. Data were collected …

Do Gender-Related Characteristics Impact Female Faculty Career Progression In Academic Doctor Of Physical Therapy Programs?, Bridget Eubanks

Internet Journal of Allied Health Sciences and Practice

Purpose: This study explored the experiences of female faculty in academic Doctor of Physical Therapy (DPT) programs in the US and if gender, or more specifically any gender-related characteristics such as pregnancy or motherhood, impacts female faculty career progression. Evidence has demonstrated that several challenges disproportionately affect women in academia, but there is currently no research available related to female faculty experiences in academic DPT programs. Methods: This study used a qualitative research design with a descriptive statistics component. It utilized a descriptive, cross-sectional design with a nonexperimental survey methodology. The Culture Conducive to Women’s Academic Success instrument was used …