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Genetic Study Of Von Willebrand Factor Antigen Levels ≤ 50 Iu/Dl Identifies Variants Associated With Increased Risk Of Von Willebrand Disease And Bleeding, Rachel K Friedman, Adam S Heath, Jennifer E Huffman, James T Baker, Natalie R Hasbani, Sarah A Gagliano Taliun, Ming-Huei Chen, Tom E Howard, Joshua P Lewis, Nathan Pankratz, Snehal Patil, Alex P Reiner, Florian Thibord, Lisa R Yanek, Jie Yao, Hung-Hsin Chen, Joanne E Curran, Nauder Faraday, Xiuqing Guo, Marsha M Wheeler, Kathleen A Ryan, Xiang Zhou, Kelly Cho, Laura Almasy, Paul L Auer, Lewis C Becker, Peter W F Wilson, Eric Boerwinkle, Jeffrey R O'Connell, Stephen S Rich, David C Samuels, National Heart, Lung And Blood Institute (Nhlbi) Trans-Omics For Precision Medicine (Topmed) Consortium, Topmed Hematology & Hemostasis Working Group, Va Million Veteran Program, John Blangero, Myriam Fornage, Charles Kooperberg, Rasika A Mathias, Braxton D Mitchell, Jerome I Rotter, Andrew D Johnson, Nicholas L Smith, Zeynep H Coban-Akdemir, Jennifer E Below, Alanna C Morrison, Jill M Johnsen, Paul S De Vries

Faculty, Staff and Student Publications

Background: von Willebrand disease (VWD) is a common inherited bleeding disorder caused by low levels or activity of circulating von Willebrand factor (VWF). Genetic susceptibility to VWF antigen (VWF:Ag) below normal (≤ 50 IU/dL) in the general population is underexplored.

Objectives: To identify genetic variants influencing VWF:Ag levels ≤ 50 IU/dL.

Methods: We performed a genome-wide association study in 926 cases with VWF:Ag levels ≤ 50 IU/dL and 12 846 controls from 7 studies from the Trans-Omics for Precision Medicine program. We then examined whether significant genome-wide findings were also associated with clinical diagnosis of VWD in 5 biobanks with …

Socioeconomic Status Shapes Dyadic Interactions: Examining Behavioral And Physiologic Responses, Jacinth J. X. Tan, Tessa V. West, Wendy B. Mendes

Research Collection School of Social Sciences

With more opportunities for diverse interactions, little is known about how social interactions involving people of different socioeconomic status (SES) may unfold. We investigated social attunement patterns in dyadic interactions involving SES. Unacquainted individuals recruited from the community interacted with similar-or-different-SES partners in the lab (Ndyads = 130). Attunement was assessed throughout the interaction by examining physiological linkage—how much a person’s physiological change is predicted by another’s physiological change, over time. Overall, low-SES participants showed stronger physiological linkage—indicating greater attunement—to partners across SES. Participants also appeared more comfortable when interacting with low-SES partners. There were no SES differences in dominance …

Language Brokering Conditions The Indirect Association Between Mexican‐Origin Adolescents’ Academic Discrimination And Educational Expectations, Su Yeong Kim, Yayu Du, Chantal Alvarado, Wei Xiang Sim, Wen Wen, Tianlu Zhang, Jingyi Shen

Research Collection School of Social Sciences

Mexican‐origin adolescents, a significant portion of the US Latino population, often experience a decline in educational expectations from early to late adolescence. Contextual factors such as academic discrimination and language brokering for parents may contribute to this decline. This study investigates the indirect effect of academic discrimination experienced in middle school on educational expectations in young adulthood through high school grades and engagement, and the moderating role of language brokering experiences in these relations. Data were collected from 604 Mexican‐origin adolescents across four waves from 2012 to 2023. Academic discrimination experiences in middle school were negatively associated with school grades …

Dreamanime: Learning Style-Identity Textual Disentanglement For Anime And Beyond, Chenshu Xu, Yangyang Xu, Huaidong Zhang, Xuemiao Xu, Shengfeng He

Research Collection School Of Computing and Information Systems

Text-to-image generation models have significantly broadened the horizons of creative expression through the power of natural language. However, navigating these models to generate unique concepts, alter their appearance, or reimagine them in unfamiliar roles presents an intricate challenge. For instance, how can we exploit language-guided models to transpose an anime character into a different art style, or envision a beloved character in a radically different setting or role? This paper unveils a novel approach named DreamAnime, designed to provide this level of creative freedom. Using a minimal set of 2-3 images of a user-specified concept such as an anime character …

Solving Two-Stage Stochastic Integer Programs Via Representation Learning, Yaoxin Wu, Zhiguang Cao, Wen Song, Yingqian Zhang

Research Collection School Of Computing and Information Systems

Solving stochastic integer programs (SIPs) is extremely intractable due to the high computational complexity. To solve two-stage SIPs efficiently, we propose a conditional variational autoencoder (CVAE) for scenario representation learning. A graph convolutional network (GCN) based VAE embeds scenarios into a low-dimensional latent space, conditioned on the deterministic context of each instance. With the latent representations of stochastic scenarios, we perform two auxiliary tasks: objective prediction and scenario contrast, which predict scenario objective values and the similarities between them, respectively. These tasks further integrate objective information into the representations through gradient backpropagation. Experiments show that the learned scenario representations can …

Focus: Evaluating Pre-Trained Vision-Language Models On Underspecification Reasoning, Kankan Zhou, Yibin Lai, Kyriakos Mouratidis, Jing Jiang

Research Collection School Of Computing and Information Systems

Humans possess a remarkable ability to interpret underspecified ambiguous statements by inferring their meanings from contexts such as visual inputs. This ability, however, may not be as developed in recent pre-trained visionlanguage models (VLMs). In this paper, we introduce a novel probing dataset called FOCUS to evaluate whether state-of-the-art VLMs have this ability. FOCUS consists of underspecified sentences paired with image contexts and carefully designed probing questions. Our experiments reveal that VLMs still fall short in handling underspecification even when visual inputs that can help resolve the ambiguities are available. To further support research in underspecification, FOCUS will be released …

Cami: A Counselor Agent Supporting Motivational Interviewing Through State Inference And Topic Exploration, Yizhe Yang, Palakorn Achananuparp, Heyan Huang, Jing Jiang, Phey Ling Kit, Nicholas Gabriel Lim, Cameron Shi Ern Tan, Ee-Peng Lim

Research Collection School Of Computing and Information Systems

Conversational counselor agents have become essential tools for addressing the rising demand for scalable and accessible mental health support. This paper introduces CAMI, a novel automated counselor agent grounded in Motivational Interviewing (MI) – a client-centered counseling approach designed to address ambivalence and facilitate behavior change. CAMI employs a novel STAR framework, consisting of client’s state inference, motivation topic exploration, and response generation modules, leveraging large language models (LLMs). These components work together to evoke change talk, aligning with MI principles and improving counseling outcomes for diverse clients. We evaluate CAMI’s performance through both automated and expert evaluations, utilizing simulated …

How To Enable Effective Cooperation Between Humans And Nlp Models: A Survey Of Principles, Formalizations, And Beyond, Chen Huang, Yang Deng, Wenqiang Lei, Jiancheng Lv, Tat-Seng Chua, Jimmy Huang

Research Collection School Of Computing and Information Systems

With the advancement of large language models (LLMs), intelligent models have evolved from mere tools to autonomous agents with their own goals and strategies for cooperating with humans. This evolution has birthed a novel paradigm in NLP, i.e., human-model cooperation, that has yielded remarkable progress in numerous NLP tasks in recent years. In this paper, we take the first step to present a thorough review of human-model cooperation, exploring its principles, formalizations, and open challenges. In particular, we introduce a new taxonomy that provides a unified perspective to summarize existing approaches. Also, we discuss potential frontier areas and their corresponding …

Fact-Audit: An Adaptive Multi-Agent Framework For Dynamic Fact-Checking Evaluation Of Large Language Models, Hongzhan Lin, Yang Deng, Yuxuan Gu, Wenxuan Zhang, Jing Ma, See-Kiong Ng, Tat-Seng Chua

Research Collection School Of Computing and Information Systems

Large Language Models (LLMs) have significantly advanced the fact-checking studies. However, existing automated fact-checking evaluation methods rely on static datasets and classification metrics, which fail to automatically evaluate the justification production and uncover the nuanced limitations of LLMs in fact-checking. In this work, we introduce FACT-AUDIT, an agent-driven framework that adaptively and dynamically assesses LLMs’ fact-checking capabilities. Leveraging importance sampling principles and multi-agent collaboration, FACT-AUDIT generates adaptive and scalable datasets, performs iterative model-centric evaluations, and updates assessments based on model-specific responses. By incorporating justification production alongside verdict prediction, this framework provides a comprehensive and evolving audit of LLMs’ factual reasoning …

Non-Homophilic Graph Pre-Training And Prompt Learning, Xingtong Yu, Jie Zhang, Yuan Fang, Renhe Jiang

Research Collection School Of Computing and Information Systems

Graphs are ubiquitous for modeling complex relationships between objects across various fields. Graph neural networks (GNNs) have become a mainstream technique for graph-based applications, but their performance heavily relies on abundant labeled data. To reduce labeling requirement, pre-training and prompt learning has become a popular alternative. However, most existing prompt methods do not distinguish between homophilic and heterophilic characteristics in graphs. In particular, many real-world graphs are non-homophilic-neither strictly nor uniformly homophilic-as they exhibit varying homophilic and heterophilic patterns across graphs and nodes. In this paper, we propose ProNoG, a novel pre-training and prompt learning framework for such non-homophilic graphs. …

Other Orienteering Problem Variants, Pieter Vansteenwegen, Aldy Gunawan

Research Collection School Of Computing and Information Systems

In this chapter, different variants of routing problems with profits will be discussed. Based on what is available in literature, mostly variants of the orienteering problem will be discussed. A first variant considers capacity constraints, since these appear frequently in many practical applications. Next, multi-objective orienteering problems, explicitly considering different types of profits separately are discussed. Time-dependent and stochastic travel times are also relevant for most practical applications. These are considered together with time-dependent and stochastic profits. More and more routing problems are considered together with inventory management. For routing problems with profits, this leads to the inventory orienteering problem, …

Optimal Transport Alignment Of User Preferences From Ratings And Texts, Nhu Thuat Tran, Hady Wirawan Lauw

Research Collection School Of Computing and Information Systems

Modeling hidden factors driving user preferences is crucial for recommendation yet challenging due to sparse rating data. While aligning preference factors from ratings and texts, as a solution, shows improvements, existing methods impose restrictive one-to-one factor correspondences and underutilize cross-modal interest signals. We propose an optimal transport (OT) approach to address these gaps. By modeling rating- and text-based preference factors as distributions, we compute an OT plan that captures their probabilistic relationships. This plan serves dual roles: 1) to regularize cross-modal preference factors without rigid correspondence assumptions, and 2) to blend preference signals across modalities through barycentric mapping. Experiments on …

Analysis Of Extended Producer Responsibility In E-Waste Management: Policy Drivers And Challenges In Singapore, Aldy Gunawan, Aidan Marc Wong, Tasaporn Visawameteekul, Minh Phuong Huynh, Linh Chi Tran

Research Collection School Of Computing and Information Systems

This paper examines the role of the Extended Producer Responsibility (EPR) scheme in electronic waste (e-waste) management in Singapore. It investigates the policy drivers and challenges of e-waste management, using data from an online survey to explore the attitudes and behaviors of young consumers, with a particular focus on youth. We employ the Theory of Reasoned Action (TRA) and the Theory of Planned Behavior (TPB) frameworks to develop a model that examines the relationships among attitudes, perceived norms, awareness, and perceived convenience in relation to EPR awareness and perception. The findings highlight the need for customized policies tailored to different …

Leveraging Reviewer Experience In Code Review Comment Generation, Hong Yi Lin, Patanamon Thongtanunam, Christoph Treude, Michael W. Godfrey, Chunhua Liu, Wachiraphan Charoenwet

Research Collection School Of Computing and Information Systems

Modern code review is a ubiquitous software quality assurance process aimed at identifying and resolving potential issues (e.g., functional, evolvability) within newly written code. Despite its effectiveness, the process demands large amounts of effort from the human reviewers involved. To help alleviate this workload, researchers have trained various deep learning based language models to imitate human reviewers in providing natural language code reviews for submitted code. Formally, this automation task is known as code review comment generation. Prior work has demonstrated improvements in code review comment generation by leveraging machine learning techniques and neural models, such as transfer learning and …

Eformer: An Effective Edge-Based Transformer For Vehicle Routing Problems, Dian Meng, Zhiguang Cao, Yaoxin Wu, Yaqing Hou, Hongwei Ge, Qiang Zhang

Research Collection School Of Computing and Information Systems

Recent neural heuristics for the Vehicle Routing Problem (VRP) primarily rely on node coordinates as input, which may be less effective in practical scenarios where real cost metrics--such as edge-based distances--are more relevant. To address this limitation, we introduce EFormer, an Edge-based Transformer model that uses edge as the sole input for VRPs. Our approach employs a precoder module with a mixed-score attention mechanism to convert edge information into temporary node embeddings. We also present a parallel encoding strategy characterized by a graph encoder and a node encoder, each responsible for processing graph and node embeddings in distinct feature spaces, …

Graph Positional Autoencoders As Self-Supervised Learners, Yang Liu, Deyu Bo, Wenxuan Cao, Yuan Fang, Yawen Li, Chuan Shi

Research Collection School Of Computing and Information Systems

Graph self-supervised learning seeks to learn effective graph representations without relying on labeled data. Among various approaches, graph autoencoders (GAEs) have gained significant attention for their efficiency and scalability. Typically, GAEs take incomplete graphs as input and predict missing elements, such as masked node features or edges. Although effective, our experimental investigation reveals that traditional feature or edge masking paradigms primarily capture low-frequency signals in the graph and fail to learn expressive structural information. To address these issues, we propose Graph Positional Autoencoders (GraphPAE), which employ a dual-path architecture to reconstruct both node features and positions. Specifically, the feature path …

Xfinbench: Benchmarking Llms In Complex Financial Problem Solving And Reasoning, Zhihan Zhang, Yixin Cao, Lizi Liao

Research Collection School Of Computing and Information Systems

Solving financial problems demands complex reasoning, multimodal data processing, and a broad technical understanding, presenting unique challenges for current large language models (LLMs). We introduce **XFinBench**, a novel benchmark with 4,235 examples designed to evaluate LLM’s ability in solving comple**X**, knowledge-intensive **Fin**ancial problems across diverse graduate-level finance topics with multi-modal context. We identify five core capabilities of LLMs using XFinBench, i.e., _terminology understanding_, _temporal reasoning_, _future forecasting_, _scenario planning_, and _numerical modelling_. Upon XFinBench, we conduct extensive experiments on 18 leading models. The result shows that o1 is the best-performing text-only model with an overall accuracy of 67.3%, but still …

Taclr: A Scalable And Efficient Retrieval-Based Method For Industrial Product Attribute Value Identification, Yindu Su, Huike Zou, Lin Sun, Ting Zhang, Haiyang Yang, Chen Li Yu, David Lo, Qingheng Zhang, Shuguang Han, Jufeng Chen

Research Collection School Of Computing and Information Systems

Product Attribute Value Identification (PAVI) involves identifying attribute values from product profiles, a key task for improving product search, recommendation, and business analytics on e-commerce platforms. However, existing PAVI methods face critical challenges, such as inferring implicit values, handling outof-distribution (OOD) values, and producing normalized outputs. To address these limitations, we introduce Taxonomy-Aware Contrastive Learning Retrieval (TACLR), the first retrieval-based method for PAVI. TACLR formulates PAVI as an information retrieval task by encoding product profiles and candidate values into embeddings and retrieving values based on their similarity. It leverages contrastive training with taxonomy-aware hard negative sampling and employs adaptive inference …

Fine‑Tuning Multimodal Large Language Models For Product Bundling, Xiaohao Liu, Jie Wu, Zhulin Tao, Yunshan Ma, Yinwei Wei, Tat-Seng Chua

Research Collection School Of Computing and Information Systems

Recent advances in product bundling have leveraged multimodal information through sophisticated encoders, but remain constrained by limited semantic understanding and a narrow scope of knowledge. Therefore, some attempts employ In-context Learning (ICL) to explore the potential of large language models (LLMs) for their extensive knowledge and complex reasoning abilities. However, these efforts are inadequate in understanding mulitmodal data and exploiting LLMs' knowledge for product bundling. To bridge the gap, we introduce Bundle-MLLM, a novel framework that fine-tunes LLMs through a hybrid item tokenization approach within a well-designed optimization strategy. Specifically, we integrate textual, media, and relational data into a unified …

Anomalygfm: Graph Foundation Model For Zero/Few-Shot Anomaly Detection, Hezhe Qiao, Chaoxi Niu, Ling Chen, Guansong Pang

Research Collection School Of Computing and Information Systems

Graph anomaly detection (GAD) aims to identify abnormal nodes that differ from the majority of the nodes in a graph, which has been attracting significant attention in recent years. Existing generalist graph models have achieved remarkable success in different graph tasks but struggle to generalize to the GAD task. This limitation arises from their difficulty in learning generalized knowledge for capturing the inherently infrequent, irregular and heterogeneous abnormality patterns in graphs from different domains. To address this challenge, we propose AnomalyGFM, a GAD-oriented graph foundation model that supports zero-shot inference and few-shot prompt tuning for GAD in diverse graph datasets. …

Affinitytune: A Prompt-Tuning Framework For Few-Shot Anomaly Detection On Graphs, Jingyan Chen, Guanghui Zhu, Guansong Pang, Chunfeng Yuan, Yihua Huang

Research Collection School Of Computing and Information Systems

Graph anomaly detection (GAD) is a critical task with applications in domains such as networking, finance, and bioinformatics. % However, the scarcity of labeled anomalies and the limitations of unsupervised methods hinder effective detection. % While semi-supervised and few-shot learning approaches offer improvements, they struggle with knowledge transfer and rely heavily on labeled data. % Recent advancements in prompt tuning on graphs provide a promising direction, but their application to heterophilous graphs in anomaly detection remains underexplored. % In this work, we propose AffinityTune, a novel framework for few-shot graph anomaly detection based on prompt tuning. % Our approach introduces …

Llm2rec: Large Language Models Are Powerful Embedding Models For Sequential Recommendation, Yingzhi He, Xiaohao Liu, An Zhang, Yunshan Ma, Tat‑Seng Chua

Research Collection School Of Computing and Information Systems

Sequential recommendation aims to predict users' future interactions by modeling collaborative filtering (CF) signals from historical behaviors of similar users or items. Traditional sequential recommenders predominantly rely on ID-based embeddings, which capture CF signals through high-order co-occurrence patterns. However, these embeddings depend solely on past interactions, lacking transferable knowledge to generalize to unseen domains. Recent advances in large language models (LLMs) have motivated text-based recommendation approaches that derive item representations from textual descriptions. While these methods enhance generalization, they fail to encode CF signals-i.e., latent item correlations and preference patterns-crucial for effective recommendation. We argue that an ideal embedding model …

Collisionrepair: First‑Aid And Automated Patching For Storage Collision Vulnerabilities In Smart Contracts, Yu Pan, Wanjing Han, Yue Duan, Mu Zhang

Research Collection School Of Computing and Information Systems

Storage collision vulnerabilities, a significant security risk in upgradeable smart contracts, often arise when a user-facing proxy contract and a backend logic contract share storage space. While static analysis techniques can detect such issues, they often over-approximate program states, leading to false positives and requiring developers to manually verify each issue, giving attackers time to exploit any overlooked vulnerabilities. To address this, we propose COLLISIONREPAIR, an automated patching technique for mitigating storage collision risks. COLLISIONREPAIR monitors storage access sequences between proxy and logic contracts by defining an "ownership" property for storage locations. It then replays historical transactions to recover existing …

Prism: To Fortify Widget Based User‑App Data Exchanges Using Android Virtualization Framework, Yingtat Ng, Zhe Chen, Haiqing Qiu, Xuhua Ding

Research Collection School Of Computing and Information Systems

We present Prism, an UI hardening technique for an Android app to safeguard its widgets against a corrupted kernel. Prism ensures secure interface rendering and allows for visual authentication, which developers could use to enable user intent confidentiality protection. Our design leverages the recent Android Virtualization Framework with minimal changes to the existing UI framework and graphics subsystem. It is much easier to deploy and use Prism on Android phones than TrustZone-based secure UI schemes, because the apps are not admitted to the Secure World and retain their full rights to manage and control their own interfaces. We have implemented …

Achilles: A Formal Framework Of Leaking Secrets From Signature Schemes Via Rowhammer, Junkai Liang, Zhi Zhang, Xin Zhang, Qingni Sheng, Yansong Gao, Xinliang Yuan, Haiyang Xue, Pengfei Wu, Zhonghai. Wu

Research Collection School Of Computing and Information Systems

Signature schemes are a fundamental component of cyber-security infrastructure. While they are designed to be mathematically secure against cryptographic attacks, they are vulnerable to Rowhammer fault-injection attacks. Since all existing attacks are ad-hoc in that they target individual parameters of specific signature schemes, it remains unclear about the impact of Rowhammer on signature schemes as a whole.In this paper, we present Achilles, a formal framework that aids in leaking secrets in various real-world signature schemes via Rowhammer. Particularly, Achilles can be used to find potentially more vulnerable parameters in schemes that have been studied before and also new schemes that …

Improved Secure Two-Party Computation From A Geometric Perspective, Hao Guo, Liqiang Peng, Haiyang Xue, Li Peng, Weiran Liu, Zhe Liu, Lei. Hu

Research Collection School Of Computing and Information Systems

Multiplication and other non-linear operations are widely recognized as the most costly components of secure two-party computation (2PC) based on linear secret sharing. Moreover, the comparison protocol (or Wrap protocol) is essential for various operations such as truncation, signed extension, and signed non-uniform multiplication. This paper aims to optimize these protocols by avoiding invoking the costly comparison protocol, thereby improving their efficiency.We propose a novel approach to study 2PC from a geometric perspective. Specifically, we interpret the two shares of a secret as the horizontal and vertical coordinates of a point in a Cartesian coordinate system, with the secret itself …

August 2025 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Advancing Real-World Implementation Of The Well Optimized Linear Finder (Wolf) High-Speed Atmospheric Turbulence Compensation Method, Timothy Evan Coon

Theses and Dissertations

This dissertation advances the real-world implementation of the Well Optimized Linear Finder (WOLF) method for high-speed Atmospheric Turbulence Compensation (ATC). Atmospheric turbulence introduces phase aberrations into optical wavefronts and degrades image quality in terrestrial imaging systems. Traditional phase diversity methods are computationally intensive and poorly suited to real-time operation. The WOLF method addresses these limitations through a novel, point-wise formulation of the optical transfer function (OTF) as a structured autocorrelation of the generalized pupil function (GPF). This formulation enables the estimation of phase aberrations at individual spatial coordinates with distributed computational complexity.

The research begins by developing a MATLAB-based simulation …

Designing A User-Centered Bias System To Enhance Media Literacy And Factual Accuracy, Anjali Majan

Theses and Dissertations

In an era of rapid news consumption, readers often struggle to detect bias and misinformation. This study examined whether interface design can support more critical engagement with news. We developed a progressive disclosure interface that encouraged users to reflect as they read by gradually revealing bias and factual cues. Participants were assigned to either Progressive Disclosure or Ground News. The experiment involved two phases. In the intervention phase, participants used an interface with support features. In the assessment phase, they completed tasks without the tool. We evaluated their performance using five measures: bias recognition accuracy, bias shift, factuality judgment, overlap …

Investigating Global Lightning Observed From Ground And Space, And Its Relationship To Solar Activity, Megan Diane Mark

Theses and Dissertations

The extremes of lightning, specifically lightning with long-lasting continuing currents and lightning with extremely high peak currents, are investigated from both ground- and space-based observations. Additionally, the potential solar influence on lightning is investigated on large spatial scales.

Continuing currents may occur following the impulsive flow of current during a cloud-to-ground (CG) return stroke and are usually low amplitude (from a few amperes to a few kiloamperes) and long duration (several to hundreds of milliseconds). Remotely estimating their duration from the electromagnetic fields measured by existing ground-based lightning locating systems (LLSs) is not possible, but some space-based lightning detection systems …